Nakayama Mizuho 中山瑞穂

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NAKAYAMA Mizuho 中山瑞穂

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Researcher Number	20398225
Other IDs
Affiliation (Current)	2025: 金沢大学, がん進展制御研究所, 准教授
Affiliation (based on the past Project Information) *help	2020 – 2023: 金沢大学, がん進展制御研究所, 准教授 2014 – 2019: 金沢大学, がん進展制御研究所, 助教
Review Section/Research Field	Principal Investigator Basic Section 50010:Tumor biology-related / Tumor biology Except Principal Investigator Carcinogenesis
Keywords	Principal Investigator 大腸がん / p53 / マウスモデル / 不均一性 / LOH / 変異p53 / 悪性化 / 転移 / 変異型p53 / Loss of heterogeneity / p53 LOH / 多段階発がんモデル / 再発 … More Except Principal Investigator … More 自然免疫 / TGF-beta / マウスモデル / 腫瘍免疫 / 微小環境 / 炎症 / 胃がん Less

変異p53タンパク質蓄積の不均一性に起因した腫瘍内局所微小環境に関する研究Principal Investigator
- Principal Investigator
  
  中山瑞穂
- Project Period (FY)
  2023 – 2025
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 50010:Tumor biology-related
- Research Institution
  Kanazawa University
In vivo analysis of communications in tumor micro-environment constructed by tumor cells carrying gain-of-function p53 mutation and p53 null mutation in colorectal cancerPrincipal Investigator
- Principal Investigator
  
  Nakayama Mizuho
- Project Period (FY)
  2020 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 50010:Tumor biology-related
- Research Institution
  Kanazawa University
Analysis of acquisition of metastasis property by p53 LOH and heterogeneity of tumor cells in CRC mouse modelPrincipal Investigator
- Principal Investigator
  
  Nakayama Mizuho
- Project Period (FY)
  2017 – 2019
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Tumor biology
- Research Institution
  Kanazawa University
Model mouse for malignant colorectal cancer progressionPrincipal Investigator
- Principal Investigator
  
  Nakayama Mizuho
- Project Period (FY)
  2014 – 2016
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Tumor biology
- Research Institution
  Kanazawa University
The role of inflammatory responses and tumor immunity in tumor development
- Principal Investigator
  
  OSHIMA Masanobu
- Project Period (FY)
  2012 – 2014
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Carcinogenesis
- Research Institution
  Kanazawa University

All 2023 2022 2021 2020 2019 2018 2017 2016 2015 Other

All Journal Article Presentation Book Patent

[Book] 病理と臨床「がんゲノム医療時代の分子腫瘍学」2022
- Author(s)
  中山瑞穂　大島浩子　大島正伸
- Total Pages
  5
- Publisher
  文光堂
- Data Source
  KAKENHI-PROJECT-20K07585
[Book] 実験医学「臨床実装が進む次世代がんバイオマーカー」2022
- Author(s)
  中山瑞穂　大島正伸
- Total Pages
  6
- Publisher
  羊土社
- Data Source
  KAKENHI-PROJECT-20K07585
[Book] 実験医学増刊「がん微小環境と標的治療」2015
- Author(s)
  大島浩子、中山瑞穂、越前佳奈恵、大島正伸
- Publisher
  羊土社
- Data Source
  KAKENHI-PROJECT-24300325
[Journal Article] Genetic Alterations and Microenvironment that Drive Malignant Progression of Colorectal Cancer: Lessons from Mouse and Organoid Models2022
- Author(s)
  Nakayama Mizuho、Wang Dong、Kok Sau Yee、Oshima Hiroko、Oshima Masanobu
- Journal Title
  
  Journal of Cancer Prevention
  
  Volume: 27 Issue: 1 Pages: 1-6
- DOI
  10.15430/jcp.2022.27.1.1
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18H04030, KAKENHI-PROJECT-19H03498, KAKENHI-PROJECT-21K15502, KAKENHI-PROJECT-22H00454, KAKENHI-PROJECT-22KF0154, KAKENHI-PROJECT-20K07585
[Journal Article] Loss of wild-type p53 promotes mutant p53-driven metastasis through acquisition of survival and tumor-initiating properties2020
- Author(s)
  Mizuho Nakayama, Chang Pyo Hong, Hiroko Oshima, Eri Sakai, Seong-Jin Kim, Masanobu Oshima
- Journal Title
  
  Nature Communications
  
  Volume: -
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K07162
[Journal Article] p53 mutation in colon cancer.2019
- Author(s)
  Nakayama M and Oshima M.
- Journal Title
  
  J Mol Cell Biol,
  
  Volume: Epub. ahead of print Issue: 4 Pages: 1-10
- DOI
  10.1093/jmcb/mjy075
- NAID
  120006605142
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K07162, KAKENHI-PUBLICLY-17H05616, KAKENHI-PROJECT-19K22558, KAKENHI-PROJECT-18H04030
[Journal Article] Combined mutation of Apc, Kras and Tgfbr2 effectively drives metastasis of intestinal cancer.2018
- Author(s)
  Sakai E, Nakayama M, Oshima H, Kouyama Y, Niida A, Fujii S, Ochiai A, Nakayama KI, Minori K, Suzuki Y, Hong CP, Ock CY, Kim SJ, Oshima M.
- Journal Title
  
  Cancer Res.
  
  Volume: 78 Issue: 5 Pages: 1334-1346
- DOI
  10.1158/0008-5472.can-17-3303
- NAID
  120006452378
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K07111, KAKENHI-PROJECT-17K19608, KAKENHI-PUBLICLY-16H01576, KAKENHI-PUBLICLY-17H05616, KAKENHI-PROJECT-25221303, KAKENHI-PROJECT-15H02362, KAKENHI-PROJECT-15H04921, KAKENHI-PROJECT-16H06279, KAKENHI-PROJECT-17K07162
[Journal Article] Intestinal cancer progression by mutant p53 through the acquisition of invasiveness associated with complex glandular formation.2017
- Author(s)
  Nakayama M, Sakai K, Echizen K, Yamada Y, Oshima H, Han TS, Ohki R, Fujii S, Ochiai A, Robine S, Voon DC, Tanaka T, Taketo MM, Oshima M.
- Journal Title
  
  Oncogene
  
  Volume: 36 Issue: 42 Pages: 5885-5896
- DOI
  10.1038/onc.2017.194
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K07111, KAKENHI-PROJECT-17K07162, KAKENHI-PUBLICLY-17H05616, KAKENHI-PROJECT-15H02362
[Journal Article] Suppressing TGFβ signaling in regenerating epithelia in an inflammatory microenvironment is sufficient to cause invasive intestinal cancer.2015
- Author(s)
  Oshima H, Nakayama M, Han TS, Naoi K, Ju X, Maeda Y, Robine S, Tsuchiya K, Sato T, Sato H, Taketo MM, Oshima M.
- Journal Title
  
  Cancer Res.
  
  Volume: 75 Issue: 4 Pages: 766-776
- DOI
  10.1158/0008-5472.can-14-2036
- NAID
  120005593962
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-24590935, KAKENHI-PUBLICLY-25114703, KAKENHI-PUBLICLY-25130704, KAKENHI-PROJECT-25430107, KAKENHI-PROJECT-26430110, KAKENHI-PROJECT-25460382
[Journal Article] Suppressing TGF-β signaling in regenerating epithelia in an inflammatory microenvironment is sufficient to cause invasive intestinal cancer.2015
- Author(s)
  Oshima H, Nakayama M, Han TS, Naoi K, Ju X, Maeda Y, Robine S, Tsuchiya K, Sato T, Taketo MM, Oshima M.
- Journal Title
  
  Cancer Research
  
  Volume: 75 Pages: 754-765
- NAID
  120005593962
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-24300325
[Patent] Organoid with metastatic property and use thereof2020
- Inventor(s)
  Oshima M, Nakayama M, Sakai E
- Industrial Property Rights Holder
  Oshima M, Nakayama M, Sakai E
- Industrial Property Rights Type
  特許
- Filing Date
  2020
- Acquisition Date
  2022
- Overseas
- Data Source
  KAKENHI-PROJECT-20K07585
[Patent] オルガノイド及びその利用2017
- Inventor(s)
  大島正伸、中山瑞穂、坂井絵梨
- Industrial Property Rights Holder
  大島正伸、中山瑞穂、坂井絵梨
- Industrial Property Rights Type
  特許
- Filing Date
  2017
- Overseas
- Data Source
  KAKENHI-PROJECT-17K07162
[Patent] 特許権2017
- Inventor(s)
  大島正伸、中山瑞穂、坂井絵梨
- Industrial Property Rights Holder
  大島正伸、中山瑞穂、坂井絵梨
- Industrial Property Rights Type
  特許
- Industrial Property Number
  2017-049202
- Filing Date
  2017-03-14
- Data Source
  KAKENHI-PROJECT-26430110
[Presentation] Intra-tumor Wnt activation regulated by p53 gain-of-function mutant tumor cells2023
- Author(s)
  中山瑞穂、山本大輔、大島浩子、稲木紀幸、大島正伸
- Organizer
  第82回日本癌学会学術総会
- Data Source
  KAKENHI-PROJECT-23K06631
[Presentation] Wnt signaling activation in colon cancer cells by gain-of-function mutant p53 through COX-2/PGE2 pathway2023
- Author(s)
  Mizuho Nakayama, Hiroko Oshima, Daisuke Yamamoto, Noriyuki Inaki, Masanobu Oshima
- Organizer
  10th International MDM2 Workshop
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-23K06631
[Presentation] 大腸がん転移機構に関わる遺伝子変異と微小環境の形成についてーマウスオルガノイドモデルによる検証ー2022
- Author(s)
  中山瑞穂
- Organizer
  第31回日本がん転移学会学術総会
- Data Source
  KAKENHI-PROJECT-20K07585
[Presentation] The mechanisms of Wnt hyperactivation in intestinal tumor cells that carry gain-of functions p53 mutation2022
- Author(s)
  Nakayama M, Oshima H, Oshima M
- Organizer
  第81回　日本癌学会学術総会
- Data Source
  KAKENHI-PROJECT-20K07585
[Presentation] Loss of wild-type p53 promotes colon cancer metastasis that express gain-of-function mutant p532021
- Author(s)
  Mizuho Nakayama, Chang Pyo Hong, Hiroko Oshima, Eri Sakai, Seong-Jin Kim, Masanobu Oshima
- Organizer
  The 79th Annual Meeting of Japanese Cancer Association
- Data Source
  KAKENHI-PROJECT-20K07585
[Presentation] Gain-of-function mutant p53 hyperactivates Wnt signaling in colon cancer cells2021
- Author(s)
  Mizuho Nakayama, Hiroko Oshima, Masanobu Oshima
- Organizer
  The 80th Annual Meeting of Japanese Cancer Association
- Data Source
  KAKENHI-PROJECT-20K07585
[Presentation] がん悪性化モデルマウスとオルガノイドを使った解析ー変異型p53のがんにおける新規機能ー2019
- Author(s)
  中山瑞穂
- Organizer
  大阪大学蛋白質研究所セミナー「がん研究の新機軸」
- Data Source
  KAKENHI-PROJECT-17K07162
[Presentation] 変異型p53における野生型p53 欠失によるp53-Loss of heterogeneityは、潜在性がんとしての性質を亢進する2019
- Author(s)
  Mizuho Nakayama, Eri Sakai, Hiroko Oshima, Seong-Jin Kim, Masanobu Oshima
- Organizer
  第78回日本がん学会
- Data Source
  KAKENHI-PROJECT-17K07162
[Presentation] Combination of gain-of-function muttaion and lost of wild-type allele in p53 promotes colon cancer tumorigenicity.2018
- Author(s)
  Nakayama M, Sakai E, Suzuki Y, Oshima H, Oshima M.
- Organizer
  第77回日本がん学会
- Data Source
  KAKENHI-PROJECT-17K07162
[Presentation] Novel model systems for colon cancer progression by accumulation of multiple driver mutations2017
- Author(s)
  中山　瑞穂、坂井絵梨、大島浩子、越前佳奈恵、藤井誠志、落合淳志、中山敬一、大島正伸
- Organizer
  第76回日本癌学会
- Place of Presentation
  パシフィコ横浜　横浜市
- Year and Date
  2017-09-28
- Invited
- Data Source
  KAKENHI-PROJECT-26430110
[Presentation] Novel model systems for colon cancer progression by accumulation of multiple driver mutations2017
- Author(s)
  Mizuho Nakayama, Eri Sakai, Hiroko Oshima, Kanae Echizen, Satoshi Fujii, Atsusi Ochiai, Keiichi I. Nakayama, Masanobu Oshima
- Organizer
  第76回日本がん学会
- Invited
- Data Source
  KAKENHI-PROJECT-17K07162
[Presentation] Colon cancer malignant progression by mutant p53 through hyper-activation of Wnt signaling and induction of inflammatory pathway2017
- Author(s)
  Masanobu Oshima, Mizuho Nakayama, Eri Sakai
- Organizer
  第40回分子生物学会年会
- Invited
- Data Source
  KAKENHI-PROJECT-17K07162
[Presentation] Nuclear localized mutant p53 causes invasion and metastasis by drastic morphological changes of colorectal tumor gland.2016
- Author(s)
  中山　瑞穂、坂井絵梨、越前佳奈恵、大島浩子、Tae-su Han、大木理恵子、落合淳志、Dominic C. Voon、武藤誠、大島正伸
- Organizer
  第75回日本癌学会
- Place of Presentation
  パシフィコ横浜　横浜市
- Year and Date
  2016-10-06
- Data Source
  KAKENHI-PROJECT-26430110
[Presentation] 変異型p53による大腸がん浸潤とそのメカニズム2015
- Author(s)
  中山　瑞穂、坂井絵梨、大島浩子、武藤　誠、大島正伸
- Organizer
  第74回がん学会
- Place of Presentation
  愛知県名古屋市
- Year and Date
  2015-10-08
- Data Source
  KAKENHI-PROJECT-26430110
[Presentation] Mutant p53 increase invasive adenocarcinoma of intestinal tumors in Apc Δ716 mice.2015
- Author(s)
  Mizuho Nakayama, Eri Sakai, Hiroko Oshima, Makoto M. Taketo, Masanobu Oshima
- Organizer
  The 10th International Symposium of the Institute Network "Towards the next generation research for cancer and Immunology"
- Place of Presentation
  北海道札幌市　北海道大学
- Year and Date
  2015-07-23
- Data Source
  KAKENHI-PROJECT-26430110
[Presentation] p53 mutation induces malignant progression of intestinal tumors in Apc Δ716 mice
- Author(s)
  Mizuho Nakayama, Hiroko Oshima, Eri Sakai, Makoto M. Taketo, Masanobu Oshima
- Organizer
  日本がん学会シンポジウム／共同利用・共同研究拠点シンポジウム
- Place of Presentation
  石川県金沢市
- Year and Date
  2015-02-21 – 2015-02-22
- Data Source
  KAKENHI-PROJECT-26430110
[Presentation] Progression to malignant adenocarcinoma of intestinal tumors by p53 mutation in Apc Δ716 mice.
- Author(s)
  Mizuho Nakayama, Hiroko Oshima, Masanobu Oshima
- Organizer
  第73回日本がん学会
- Place of Presentation
  神奈川県横浜市
- Year and Date
  2014-09-25 – 2014-09-27
- Data Source
  KAKENHI-PROJECT-26430110

1. OSHIMA Masanobu (40324610)

# of Collaborated Projects: 1 results

# of Collaborated Products: 3 results
2. OSHIMA Hiroko (80362515)

# of Collaborated Projects: 1 results

# of Collaborated Products: 4 results
3. ISHIKAWA Tomoo (70322162)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
4. Ida Miyuki

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
5. 土屋輝一郎

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Nakayama Mizuho 中山 瑞穂

NAKAYAMA Mizuho 中山 瑞穂

Research Projects

Research Products

Co-Researchers

変異p53タンパク質蓄積の不均一性に起因した腫瘍内局所微小環境に関する研究Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

In vivo analysis of communications in tumor micro-environment constructed by tumor cells carrying gain-of-function p53 mutation and p53 null mutation in colorectal cancerPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Analysis of acquisition of metastasis property by p53 LOH and heterogeneity of tumor cells in CRC mouse modelPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Model mouse for malignant colorectal cancer progressionPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

The role of inflammatory responses and tumor immunity in tumor development

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Book] 病理と臨床「がんゲノム医療時代の分子腫瘍学」2022

Author(s)

Total Pages

Publisher

Data Source

[Book] 実験医学「臨床実装が進む次世代がんバイオマーカー」2022

Author(s)

Total Pages

Publisher

Data Source

[Book] 実験医学増刊「がん微小環境と標的治療」2015

Author(s)

Publisher

Data Source

[Journal Article] Genetic Alterations and Microenvironment that Drive Malignant Progression of Colorectal Cancer: Lessons from Mouse and Organoid Models2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Loss of wild-type p53 promotes mutant p53-driven metastasis through acquisition of survival and tumor-initiating properties2020

Author(s)

Journal Title

Data Source

[Journal Article] p53 mutation in colon cancer.2019

Author(s)

Journal Title

DOI

NAID

Data Source

[Journal Article] Combined mutation of Apc, Kras and Tgfbr2 effectively drives metastasis of intestinal cancer.2018

Author(s)

Journal Title

DOI

NAID

Data Source

[Journal Article] Intestinal cancer progression by mutant p53 through the acquisition of invasiveness associated with complex glandular formation.2017

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Suppressing TGFβ signaling in regenerating epithelia in an inflammatory microenvironment is sufficient to cause invasive intestinal cancer.2015

Author(s)

Journal Title

DOI

NAID

Nakayama Mizuho 中山瑞穂

NAKAYAMA Mizuho 中山瑞穂