Kobayashi Maki 小林牧

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KOBAYASHI Maki 小林牧

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Researcher Number	20400690
Affiliation (Current)	2025: 京都大学, 医学研究科, 特定准教授
Affiliation (based on the past Project Information) *help	2015 – 2024: 京都大学, 医学研究科, 特定准教授 2012 – 2015: 京都大学, 医学(系)研究科(研究院), 准教授 2012: 京都大学, 大学院・医学研究科, 准教授 2011: 京都大学, 医学研究科, 准教授 2010: 京都大学, 医学研究科, 特定准教授 2009: 京都大学, 医学研究科, 准教授
Review Section/Research Field	Principal Investigator Molecular biology / Basic Section 44010:Cell biology-related / Basic Section 43010:Molecular biology-related Except Principal Investigator Medium-sized Section 49:Pathology, infection/immunology, and related fields / Biological Sciences
Keywords	Principal Investigator AID / トポイソメラーゼ１ / miRNA / ゲノム不安定化 / aicda / AICDA / 抗体遺伝子 / RNA編集 / Topoisomerase1 / DNA切断 … More / 免疫グロブリン遺伝子 / 転写依存的ゲノム不安定性 / germline transcripts / IgH遺伝子 / 核内転写活性化領域 / アンチセンスオリゴ / 抗体遺伝子組換え / RNA干渉 / クラススイッチ組換え / 抗体遺伝子多様化 / 体細胞突然変異 / クラススイッチ / Ago2 / 遺伝子不安定性 / ゲノム不安定性 / 翻訳調節 / Non-B DNA / 免疫グロブリン / non-B DNA … More Except Principal Investigator RNA編集 / 体細胞突然変異 / R-ループ / hnRNP U / hnRNP K / 液一液相分離 / 液ー液相分離 / エンハンサー由来RNA / 抗体遺伝子組換え / 遺伝子組換え / トポイソメラーゼ　１ / トポイソメラーゼ１ / トポイソメラーゼ 1 / 免疫グロブリン遺伝子 / AID / FACT複合体 / 大規模シークエンス / 免疫帰国 / 獲得免疫 / 組換え / DNA切断 / DNA修復 / クラススイッチ組換え / 癌 / ゲノム / 抗体 / 免役学 / マイクロアレイ法 / 免疫沈降法 / ウラシルDNAグリコシラーゼ / クラススイッチ Less

効率的な抗体遺伝子組換えにおける液ー液相分離複合体の重要性の解析Principal Investigator
- Principal Investigator
  
  小林牧
- Project Period (FY)
  2022 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 44010:Cell biology-related
- Research Institution
  Kyoto University
Molecular mechanism of the AID-recombinosome formation which is essential for vaccine-induced antibody gene diversification
- Principal Investigator
  
  本庶佑
- Project Period (FY)
  2022 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Review Section
  
  Medium-sized Section 49:Pathology, infection/immunology, and related fields
- Research Institution
  Kyoto University
Transcription-dependent IgH gene instability by RNA interferencePrincipal Investigator
- Principal Investigator
  
  Kobayashi Maki
- Project Period (FY)
  2019 – 2021
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 43010:Molecular biology-related
- Research Institution
  Kyoto University
Analysis of the molecular mechanism of IgH gene diversification depending on RNA-editing by AID
- Principal Investigator
  
  HONJO TASUKU
- Project Period (FY)
  2019 – 2021
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Review Section
  
  Medium-sized Section 49:Pathology, infection/immunology, and related fields
- Research Institution
  Kyoto University
Molecular mechanism of genomic instability by RNA editingPrincipal Investigator
- Principal Investigator
  
  Kobayashi Maki
- Project Period (FY)
  2016 – 2018
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Molecular biology
- Research Institution
  Kyoto University
Genomic instability by Topoisomerase 1 induced by AID-dependent RNA editingPrincipal Investigator
- Principal Investigator
  
  Kobayashi Maki
- Project Period (FY)
  2013 – 2015
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Molecular biology
- Research Institution
  Kyoto University
Regulatory mechanism of Topoisomerase1 by small RNA molecules which leads genomic instabilityPrincipal Investigator
- Principal Investigator
  
  KOBAYASHI Maki
- Project Period (FY)
  2010 – 2012
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Molecular biology
- Research Institution
  Kyoto University
Mechanism for genome instability by activation induced cytidine deaminase induced-reduction of topoisomerase1
- Principal Investigator
  
  HONJO Tasuku
- Project Period (FY)
  2010 – 2015
- Research Category
  
  Grant-in-Aid for Specially Promoted Research
- Review Section
  
  Biological Sciences
- Research Institution
  Kyoto University
AID-dependent genetic alteration mechanism to generate antigen-specific antibodies
- Principal Investigator
  
  HONJO Tasuku
- Project Period (FY)
  2005 – 2009
- Research Category
  
  Grant-in-Aid for Specially Promoted Research
- Review Section
  
  Biological Sciences
- Research Institution
  Kyoto University

[Journal Article] Ago2 and a miRNA reduce Topoisomerase 1 for enhancing DNA cleavage in antibody diversification by activation-induced cytidine deaminase2023
- Author(s)
  Maki Kobayashi, Hiroyuki Wakaguri, Masakazu Shimizu, Koichiro Higasa, Fumihiko Matsuda, and Tasuku Honjo
- Journal Title
  
  PNAS USA
  
  Volume: 120 (18) e2216918120 h Issue: 18
- DOI
  10.1073/pnas.2216918120
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-22H00449, KAKENHI-PROJECT-23K21722
[Journal Article] Necessity of HuR/ELAVL1 for activation-induced cytidine deaminase-dependent decrease in topoisomerase 1 in antibody diversification.2023
- Author(s)
  Wajid Amin, Shoki Nishio, Tasuku Honjo, and Maki Kobayashi
- Journal Title
  
  International Immunology
  
  Volume: 35(8) Issue: 8 Pages: 361-375
- DOI
  10.1093/intimm/dxad011
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-22H00449
[Journal Article] SAMHD 1‐mediated dNTP degradation is required for efficient DNA repair during antibody class switch recombination2020
- Author(s)
  Husain Afzal、Xu Jianliang、Fujii Hodaka、Nakata Mikiyo、Kobayashi Maki、Wang Ji‐Yang、Rehwinkel Jan、Honjo Tasuku、Begum Nasim A
- Journal Title
  
  The EMBO Journal
  
  Volume: 39 Issue: 15
- DOI
  10.15252/embj.2019102931
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K07547, KAKENHI-PROJECT-19H01027, KAKENHI-PROJECT-19K06485
[Journal Article] RNA-binding motifs of hnRNP K are critical for induction of antibody diversification by activation-induced cytidine deaminase2020
- Author(s)
  Ziwei Yin, iMaki Kobayashi, Wenjun Hu, Koichi Higashi, Nasim A Begum, Ken Kurokawa, Tasuku Honjo
- Journal Title
  
  Proceedings of the National Academy of Sciences of the United States of America
  
  Volume: in press Issue: 21 Pages: 11624-11635
- DOI
  10.1073/pnas.1921115117
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K06485, KAKENHI-PROJECT-19H01027, KAKENHI-PROJECT-16H06279
[Journal Article] Antibody class switch recombination requires SAMHD1-mediated dNTP degradation to promote DNA repair2020
- Author(s)
  Afzal Husain, Jiangling Xu, Hodaka Fuji, Mikiyo Nakata, Kobayashi Maki, Ji- Yang Wang, Jan Rehwinkel, Tasuku Honjo, Nasim A. Begum
- Journal Title
  
  EMBO J.
  
  Volume: under revision
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19H01027
[Journal Article] Apurinic/apyrimidinic endonuclease 1 (APE1) is dispensable for activation-induced cytidine deaminase (AID)-dependent somatic hypermutation in the immunoglobulin gene.2019
- Author(s)
  Helena Islam, Maki Kobayashi and Tasuku Honjo.
- Journal Title
  
  International Immunology
  
  Volume: -- Issue: 8 Pages: 543-554
- DOI
  10.1093/intimm/dxz028
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-15H05784, KAKENHI-PROJECT-16K07251
[Journal Article] Depletion of recombination-specific cofactors by the C-terminal mutant of the activation-induced cytidine deaminase causes the dominant negative effect on class switch recombination.2017
- Author(s)
  Al Ismail, A., Husain, A., Kobayashi, M., Honjo, T., Begum, N. A.
- Journal Title
  
  International Immunology
  
  Volume: 29 Issue: 11 Pages: 525-537
- DOI
  10.1093/intimm/dxx061
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K07214, KAKENHI-PROJECT-15H05784, KAKENHI-PROJECT-16K07251
[Journal Article] The novel activation-induced deoxycytidine deaminase (AID) mutants, AIDv and AIDvΔ15 are defective in SHM and CSR2017
- Author(s)
  Maki Kobayashi, Misao Takemoto, Tasuku Honjo
- Journal Title
  
  DNA Repair
  
  Volume: 印刷中 Pages: 1-3
- DOI
  10.1016/j.dnarep.2017.02.015
- Data Source
  KAKENHI-PROJECT-16K07251
[Journal Article] Chromatin remodeler SMARCA4 recruits topoisomerase 1 and suppresses transcription associated genomic instability2016
- Author(s)
  Afzal Husain, Nasim A. Begum, Takako Taniguchi, Hisaaki Taniguchi, Maki Kobayashi, and Tasuku Honjo.
- Journal Title
  
  Nat. Commu.
  
  Volume: 7 Issue: 1 Pages: 00-00
- DOI
  10.1038/ncomms10549
- NAID
  120006535056
- Peer Reviewed / Acknowledgement Compliant / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-25440007, KAKENHI-PROJECT-22000015, KAKENHI-PROJECT-16K07214
[Journal Article] LSD1/KDM1A promotes hematopoietic commitment of hemangioblasts through downregulation of Etv2.2015
- Author(s)
  Takeuchi, M., Fuse, Y., Watanabe, M., Andrea, C.S., Takeuchi, M., Nakajima, H., Ohashi, K., Kaneko, H., Kobayashi-Osaki, M., Yamamoto, M. and Kobayashi, M.
- Journal Title
  
  Proc. Natl. Acad. Sci. USA
  
  Volume: 112 Issue: 45 Pages: 13922-13927
- DOI
  10.1073/pnas.1517326112
- NAID
  120007135765
- Peer Reviewed / Acknowledgement Compliant / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26520101, KAKENHI-PLANNED-26111002, KAKENHI-PUBLICLY-26116705, KAKENHI-PROJECT-25440007
[Journal Article] C-terminal region of activation-induced cytidine deaminase (AID) is required for efficient class switch recombination and gene conversion.2014
- Author(s)
  Sabouri S, Kobayashi M, Begum NA, Xu J, Hirota K, Honjo T
- Journal Title
  
  Proc Natl Acad Sci U S A.
  
  Volume: 111 Issue: 6 Pages: 2253-2258
- DOI
  10.1073/pnas.1324057111
- NAID
  120005395696
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23221005, KAKENHI-PUBLICLY-24114509, KAKENHI-PROJECT-24590352, KAKENHI-PROJECT-25281021, KAKENHI-PROJECT-25440007, KAKENHI-PROJECT-22000015
[Journal Article] Activation-induced cytidine deaminase is dispensable for virus-mediated liver and skin tumor development in mouse models in press2014
- Author(s)
  Tung Nguyen,Jianliang Xu,Shunsuke Chikuma,Hiroshi Hiai,Kazuo Kinoshita,Kyoji Moriya,Kazuhiko Koike,Gian Paolo Marcuzzi, Herbert Pfister, Tasuku Honjo, and Maki Kobayashi
- Journal Title
  
  Int Immunol
  
  Volume: 未定
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-25440007
[Journal Article] Activation-induced cytidine deaminase is dispensable for virus-mediated liver and skin tumor development in mouse models.2014
- Author(s)
  Nguyen T, Xu J, Chikuma S, Hiai H, Kinoshita K, Moriya K, Koike K, Marcuzzi GP, Pfister H, Honjo T, Kobayashi M.
- Journal Title
  
  Int Immunol
  
  Volume: 26 Issue: 7 Pages: 397-406
- DOI
  10.1093/intimm/dxu040
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-24390183, KAKENHI-PROJECT-25440007, KAKENHI-PROJECT-25460363, KAKENHI-PROJECT-22000015
[Journal Article] APE1 is dispensable for S region cleavage but required for its repair in class switch recombination2014
- Author(s)
  Jianliang Xu, Afzal Husain, Wenjun Hu, Tasuku Honjo and Maki Kobayashi.
- Journal Title
  
  PNAS USA
  
  Volume: 111 Issue: 48 Pages: 17242-17247
- DOI
  10.1073/pnas.1420221111
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-25440007, KAKENHI-PROJECT-22000015
[Journal Article] In vivo analysis of Aicda gene regulation: a critical balance between upstream enhancers and intronic silencers governs appropriate expression2013
- Author(s)
  Le Thi Huong, Maki Kobayashi,et al
- Journal Title
  
  PLoSONE
  
  Volume: vol.8 Issue: 4 Pages: e61433-e61433
- DOI
  10.1371/journal.pone.0061433
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22570169, KAKENHI-PROJECT-23659151, KAKENHI-PROJECT-25440007
[Journal Article] The AID Dilemma: Infection, or Cancer?2013
- Author(s)
  Tasuku Honjo, Maki Kobayashi, Nasim Begum, Ai Kotani, Somayeh Sabour and Hitoshi Nagaoka
- Journal Title
  
  Adv Cancer Res
  
  Volume: vol.113 Pages: 1-44
- DOI
  10.1016/b978-0-12-394280-7.00001-4
- ISBN
  9780123942807
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22570169, KAKENHI-PUBLICLY-23118513, KAKENHI-PROJECT-23659151, KAKENHI-PROJECT-24590352, KAKENHI-PROJECT-22000015
[Journal Article] GATA factor switching from GATA2 to GATA1 contributes to erythroid differentiation2013
- Author(s)
  Suzuki M, Kobayashi-Osaki M, Tsutsumi S, Pan X, Ohmori S, Takai J, Moriguchi T, Ohneda O, Ohneda K, Shimizu R, Kanki Y, Kodama T, Aburatani H, Yamamoto M
- Journal Title
  
  Genes Cells
  
  Volume: 18 Issue: 11 Pages: 921-933
- DOI
  10.1111/gtc.12086
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24249015, KAKENHI-PROJECT-24590359, KAKENHI-PROJECT-24590371, KAKENHI-PROJECT-24659142, KAKENHI-PROJECT-24659456, KAKENHI-PROJECT-24710227, KAKENHI-PROJECT-24790957, KAKENHI-PUBLICLY-25118709, KAKENHI-PUBLICLY-25118722, KAKENHI-PUBLICLY-25125707, KAKENHI-PROJECT-25440007, KAKENHI-PROJECT-25860221
[Journal Article] An evolutionary view of the mechanism for immune and genome diversity2012
- Author(s)
  Lucia Kato, Andre Stanlie, Nasim A Begum, Maki Kobayashi, Masatoshi Aida, Tasuku Honjo
- Journal Title
  
  J Immunol
  
  Volume: vol. 188 Issue: 8 Pages: 3559-3566
- DOI
  10.4049/jimmunol.1102397
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22570169, KAKENHI-PROJECT-24590352, KAKENHI-PROJECT-22000015
[Journal Article] Decrease in topoisomerase I is responsible for AID-dependent somatic hypermutation2011
- Author(s)
  Kobayashi, M., et al
- Journal Title
  
  Proc.Natl.Aoad.Sci.USA
  
  Volume: 108 Pages: 19305-19310
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22000015
[Journal Article] Decrease in topoisomerase I is responsible for activation-induced cytidine deaminase (AID)-dependent somatic hypermutation2011
- Author(s)
  Maki Kobayashi,Zahra Sabouri et al
- Journal Title
  
  PNAS USA
  
  Volume: vol,108 Issue: 48 Pages: 19305-19310
- DOI
  10.1073/pnas.1114522108
- NAID
  120003692414
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22570169
[Journal Article] Preventing AID, a physiological mutator, from deleterious activation : regulation of the genomic instability that is associated with antibody diversity2010
- Author(s)
  Hitoshi Nagaoka, Thinh Huy Tran, Maki Kobayashi, Masatoshi Aida, Tasuku Honjo.
- Journal Title
  
  International Immunology
  
  Volume: 22 Pages: 227-235
- NAID
  10027391988
- Data Source
  KAKENHI-PROJECT-22570169
[Journal Article] Preventing AID, a physiological mutator, from deleterious activation: regulation of the genomic instability that is associated with antibody diversity2010
- Author(s)
  Hitoshi Nagaoka, Thinh Huy Tran, Maki Kobayashi, M a s a t o s h i A i d a a n d T a s u k u H o n j o
- Journal Title
  
  International Immunology
  
  Volume: vol 22 Issue: 4 Pages: 227-235
- DOI
  10.1093/intimm/dxq023
- NAID
  10027391988
- Data Source
  KAKENHI-PROJECT-22570169
[Journal Article] AID-induced decrease in topoisomerase 1 induces DNA structural alteration and DNA cleavage for class switch recombination.2009
- Author(s)
  Kobayashi, M., et al.
- Journal Title
  
  Proc.Natl.Acad.Sci.USA 106
  
  Pages: 22375-22380
- NAID
  120001749564
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17002015
[Journal Article] AID-induced decrease in topoisomerase 1 induces DNA structural alteration and DNA cleavage for class switch recombination.2009
- Author(s)
  Kobayashi, M., Aida, M., Nagaoka, H., Begum, N.A., Kitawaki, Y., Nakata, M., Stanlie, A., Doi, T., Kato, L., Okazaki, I., Shinkura R., Muramatsu, M., Kinoshita, K., Honjo, T.
- Journal Title
  
  Proc.Natl.Acad.Sci.USA 106
  
  Pages: 22375-22380
- NAID
  120001749564
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17002015
[Presentation] Ago2 and a miRNA reduce DNA topoisomerase 1 (Top1) for enhancing DNA cleavage in antibody diversification by activation- induced cytidine deaminase (AID).2024
- Author(s)
  Maki Kobayashi, Hiroyuki Wakaguri, Masakazu Shimizu, Koichiro Higasa, Fumihiko Matsuda, and Tasuku Honjo.
- Organizer
  第52回日本免疫学会学術集会
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-22H00449
[Presentation] Activation-induced cytidine deaminase (AID)による免疫記憶形成に必要なAgo2-miRNA依存的なtopoisomerase 1 (Top1)の調節機構2023
- Author(s)
  小林牧、若栗浩幸、清水正和、日笠幸一郎、松田文彦、本庶佑
- Organizer
  第46回日本分子生物学会集会
- Data Source
  KAKENHI-PROJECT-22H00449
[Presentation] Ago2とmiRNAはAID依存性の抗体遺伝子組換えにおけるDNA切断を促進するためにDNAトポイソメラーゼ1を減少させる2023
- Author(s)
  小林牧、若栗浩幸、清水正和、日笠幸一郎、松田文彦、本庶佑
- Organizer
  第96回日本生化学会大会
- Data Source
  KAKENHI-PROJECT-22H00449
[Presentation] The reduction of DNA top1 enhances DNA breaks in Ig gene rearrangement and is regulated by a miRNA and Ago22022
- Author(s)
  Kobayashi, Maki
- Organizer
  Antibody Diversification and DNA Deaminases in Immunity and Cancer
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-22H00449
[Presentation] DNAトポイソメラーゼ１は免疫グロブリン遺伝子組換え（多様化）に際してAIDに制御されDNA切断に働く2019
- Author(s)
  小林牧、本庶佑
- Organizer
  第42回日本分子生物学会年会
- Invited
- Data Source
  KAKENHI-PROJECT-19H01027
[Presentation] DNAトポイソメラーゼ１は免疫グロブリン遺伝子組換え（多様化）に際してAIDに制御されDNA切断に働く2019
- Author(s)
  小林牧、本庶佑
- Organizer
  第42回日本分子生物学会年会
- Invited
- Data Source
  KAKENHI-PROJECT-19K06485
[Presentation] Apurinic/apyrimidinic endonuclease 1 (APE1) is dispensable for activation-induced cytidine deaminase (AID)-dependent somatic hypermutation in the immunoglobulin gene2018
- Author(s)
  Helena Islam, Maki Kobayashi and Tasuku Honjo
- Organizer
  2nd International Symposium of Radiation Therapeutics and Biology
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K07251
[Presentation] hnRNP KのRNA結合モチーフはAIDによる免疫グロブリン遺伝子多様化に必須である2018
- Author(s)
  Ziwei Yin, Maki Kobayashi, Wenjun Hu, Nasim A. Begum, Tasuku Honjo
- Organizer
  第41回日本分子生物学会年会
- Data Source
  KAKENHI-PROJECT-16K07251
[Presentation] IgH遺伝子多様化におけるノンコーディング germline transcriptの機能2018
- Author(s)
  小林牧、本庶佑
- Organizer
  第41回日本分子生物学会年会
- Data Source
  KAKENHI-PROJECT-16K07251
[Presentation] Function of Sμ-germline transcripts in activation-induced cytidine deaminase (AID)-induced DNA breaks2018
- Author(s)
  Maki Kobayashi, Misao Takemoto, Nasim A. Begum and Tasuku Honjo
- Organizer
  The Keystone Symposia meeting on B Cells: Mechanisms in Immunity and Autoimmunity, 2018
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K07251
[Presentation] RNA-binding motifs of AID cofactor hnRNP K are necessary for inducing DNA breaks in IgH locus2018
- Author(s)
  Ziwei Yin, Maki Kobayashi, Wenjun Hu, Nasim A. Begum, Tasuku Honjo
- Organizer
  The Keystone Symposia meeting on B Cells: Mechanisms in Immunity and Autoimmunity, 2018
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K07251
[Presentation] クラススイッチ組換えにおけるメチルトランスフェラーゼFBLの役割2017
- Author(s)
  森脇隆仁、Afzal Husain、小林牧、本庶佑
- Organizer
  生命科学系学会合同年次大会
- Data Source
  KAKENHI-PROJECT-16K07251
[Presentation] Topoisomerase 1 enrolls in diversification of Ig gene under the regulation of activation-induced cytidine deaminase (AID)2017
- Author(s)
  Kobayashi, M and Honjo, T
- Organizer
  International Symposium on Immune Diversity and Cancer Therapy Kobe 2017
- Place of Presentation
  神戸市、ポートピアホテル
- Year and Date
  2017-01-26
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K07251
[Presentation] Apurinic/Apyrimidinic endonuclease 1 (APE1)'s enrollment in activation induced cytidine deaminase (AID)-dependent IgH gene diversification2017
- Author(s)
  Helena Islam、Maki Kobayashi、Tasuku Honjo
- Organizer
  生命科学系学会合同年次大会
- Data Source
  KAKENHI-PROJECT-16K07251
[Presentation] トポイソメラーゼ１を介したAIDによる免疫グロブリン遺伝子の多様化2015
- Author(s)
  小林　牧、本庶　佑
- Organizer
  第17回RNA meeting
- Place of Presentation
  札幌パークホテル
- Year and Date
  2015-07-15
- Data Source
  KAKENHI-PROJECT-25440007
[Presentation] トポイソメラーゼⅠを介したAIDによる免疫グロブリン遺伝子の多様化2015
- Author(s)
  小林牧、本庶佑
- Organizer
  第17回 RNA meeting
- Place of Presentation
  札幌パークホテル
- Year and Date
  2015-07-15
- Invited
- Data Source
  KAKENHI-PROJECT-22000015
[Presentation] Immunoglobulin gene diversification by activation-induced cytidine deaminase (AID) through Topoisomerase1 (Top1).2015
- Author(s)
  Maki Kobayashi, Hiroyuki Wakaguri, Masakazu Shimizu, Koh-ichiro Higasa, Fumihiko Matsuda and Tasuku Honjo
- Organizer
  The 2nd IFOM-Kyoto University Joint Symposium
- Place of Presentation
  京都大学芝蘭会館
- Year and Date
  2015-10-06
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-25440007
[Presentation] AID-regulated Topoisomerase1 is the DNA cleaving enzyme during immunoglobulin diversification2014
- Author(s)
  Maki Kobayashi
- Organizer
  Kyoto University & National Taiwan University Symposium
- Place of Presentation
  京都大学
- Year and Date
  2014-09-01
- Invited
- Data Source
  KAKENHI-PROJECT-25440007
[Presentation] Activation-induced cytidine deaminase regulates Topoisomerase1 protein by miRNA during immnoglobulin gene recombination2013
- Author(s)
  Maki Kobayashi et al
- Organizer
  Keystone Meeting, Noncoding RNAs in Development and Cancer
- Place of Presentation
  Fairmont Hotel Vancouver
- Year and Date
  2013-01-22
- Data Source
  KAKENHI-PROJECT-22570169
[Presentation] Activation-induced cytidine deaminase regulates Topoisomerase1 protein by miRNA during immnoglobulin gene recombination2012
- Author(s)
  Maki Kobayashi et al
- Organizer
  第35回日本分子生物学会年会
- Place of Presentation
  福岡国際会議場
- Year and Date
  2012-12-14
- Data Source
  KAKENHI-PROJECT-22570169
[Presentation] Activation-induced cytidine deaminase regulates Topoisomerase1 protein by miRNA during immnoglobulin gene recombination2012
- Author(s)
  Maki Kobayashi et al
- Organizer
  第41回日本免疫学会学術集会
- Place of Presentation
  神戸国際会議場
- Year and Date
  2012-12-06
- Data Source
  KAKENHI-PROJECT-22570169
[Presentation] AID-induced Ago2 binding to the 3' UTR of Topoisomerase I (Top1) mRNA is associated with Top1 decrease, which is responsible for somatic hypermutation and class switch recombination2012
- Author(s)
  M Kobayashi, J Xu, Z Sabouri, S Sabouri,Y Kitawaki, Y Sasaki, Y Pommier, T Honjo
- Organizer
  Keystone Symposia - Mutations, Malignancy and Memory - Antibodies and Immunity (C6)
- Place of Presentation
  ボストンパークプラザホテル
- Year and Date
  2012-03-19
- Data Source
  KAKENHI-PROJECT-22570169
[Presentation] AID-induced Ago2 binding to the 3' UTR of Topoisomerase I (Top1) mRNA is associated with Top1 decrease, which is responsible for somatic hypermutation and class switch2012
- Author(s)
  M Kobayashi, J Xu, Z Sabouri, S Sabouri, Y Kitawaki, Y Sasaki, Y
- Organizer
  Keystone Symposia-Mutations, Malignancy and Memory-Antibodies and Immunity (C6)
- Place of Presentation
  ボストンパークプラザホテル
- Year and Date
  2012-03-19
- Data Source
  KAKENHI-PROJECT-22570169
[Presentation] AID-induced Topoisomerase1 reduction regulates somatic hypermutation frequency2011
- Author(s)
  Maki Kobayashi, Zahra Sabouri, Masatoshi Aida, Yoko Kitawaki, and Tasuku Honjo
- Organizer
  第84回日本生化学会大会
- Place of Presentation
  京都
- Data Source
  KAKENHI-PROJECT-22570169
[Presentation] Decrease in topoisomerase I is responsible for AID-dependent somatic hypermutation2011
- Author(s)
  Maki Kobayashi1, Zahra Sabouri1, Somayeh Sabouri1 and Tasuku Honjo
- Organizer
  第23回日本分子生物学会、シンポジウム「ゲノムダイナミクス」
- Place of Presentation
  横浜
- Year and Date
  2011-12-15
- Data Source
  KAKENHI-PROJECT-22570169
[Presentation] Topoisomerase1 regulates AID-induced DNA cleavage2010
- Author(s)
  Maki Kobayashi, Zahra Sabouri, Masatoshi Aida, Yoko Kitawaki, and Tasuku Honjo
- Organizer
  14thInternational congress of immunology
- Place of Presentation
  神戸
- Data Source
  KAKENHI-PROJECT-22570169
[Presentation] AID-induced decrease in topoisomerase1 induces DNA structural alteration and DNA cleavage for class switch recombination.2010
- Author(s)
  Maki Kobayashi, Masatoshi Aida, Hitoshi Nagaoka, Nasim A.Begum, Tasuku Honjo.
- Organizer
  Cold Spring Harbor Meeting on Gene expression and signaling in the immune system
- Place of Presentation
  Cold Spring Harbor, New York.
- Data Source
  KAKENHI-PROJECT-22570169
[Presentation] Epigenetic regulation of S region chromatin is essential to AID-induced S region DNA cleavage by topoisomerase 1.2010
- Author(s)
  Maki Kobayashi, Masatoshi Aida, Andre Stanlie, Nasim A.Begum, Hitoshi Nagaoka, Tasuku Honjo.
- Organizer
  International AID workshop : from Immune Diversification to Cancer
- Place of Presentation
  Stockholm Sweden(招待講演)
- Data Source
  KAKENHI-PROJECT-22570169
[Presentation] Topoisomerase1 regulates AID-induced DNA cleavage.2010
- Author(s)
  Maki Kobayashi, Somayeh Sabouri, Zahra Sabouri, Yoko Kitawaki, Tasuku Honjo.
- Organizer
  Biochemistry and Molecular Biology2010
- Place of Presentation
  神戸
- Data Source
  KAKENHI-PROJECT-22570169
[Presentation] Topoisomerase1 regulates AID-induced DNA cleavage.2010
- Author(s)
  Maki Kobayashi, Zahra Sabouri, Masatoshi Aida, Yoko Kitawaki, Tasuku Honjo.
- Organizer
  14^<th> International congress of immunology
- Place of Presentation
  神戸
- Data Source
  KAKENHI-PROJECT-22570169
[Presentation] Begum and Tasuku Honjo. AID-induced decrease in topoisomerase1 induces DNA structural alteration and DNA cleavage for class switch r e c o m b i n a t i o n2010
- Author(s)
  Maki Kobayashi, Masatoshi Aida, Hitoshi Nagaoka, Nasim A
- Organizer
  C o l d S p r i n g H a r b o r Meeting on Gene expression and signaling in the immune system
- Place of Presentation
  Cold Spring Harbor, New York
- Data Source
  KAKENHI-PROJECT-22570169
[Presentation] Epigenetic regulationof S region chromatin is essential to AID-induced S region DNA cleavage by topoisomerase 12010
- Author(s)
  Maki Kobayashi, M a s a t o s h i A i d a , A n d r e Stanlie, Nasim A. Begum, Hitoshi Nagaoka and Tasuku Honjo
- Organizer
  International AID workshop: from Immune Diversification to Cancer
- Place of Presentation
  Stockholm、Sweden
- Data Source
  KAKENHI-PROJECT-22570169
[Presentation] Transcription Factors Sox13 Regulates the Hematopoietic Expression of GATA2 in Vertebrate Embryos2010
- Author(s)
  Maki Kobayashi-Osaki, Makoto Kobayashi, Miki Takeuchi and Masayuki Yamamoto
- Organizer
  9th Japanese Biochemical Society Bio-Frontier Symposium 2010, 5th International Symposium on GATA factors
- Place of Presentation
  仙台
- Data Source
  KAKENHI-PROJECT-22570169
[Presentation] Topoisomerase1 regulates AID-induced DNA cleavage2010
- Author(s)
  Maki Kobayashi, Somayeh Sabouri, Zahra Sabouri, Yoko Kitawaki, and Tasuku Honjo
- Organizer
  Biochemistry and Molecular Biology2010
- Place of Presentation
  神戸
- Data Source
  KAKENHI-PROJECT-22570169
[Presentation] Transcription Factors Sox13 Regulates the Hematopoietic Expression of GATA2 in Vertebrate Embryos.2010
- Author(s)
  Maki Kobayashi-Osaki, Makoto Kobayashi, Miki Takeuchi, Masayuki Yamamoto.
- Organizer
  9th Japanese Biochemical Society Bio-Frontier Symposium 2010, 5th International Symposium on GATA factors.Sendai
- Place of Presentation
  仙台
- Data Source
  KAKENHI-PROJECT-22570169
[Presentation] AID regulates Top1 translation by changing miRNA loading to Top1 mRNA
- Author(s)
  Maki Kobayashi, Masayuki Shimizu, Koichiro Higasa, Fumihiko Matsuda and Tasuku Honjo
- Organizer
  Frontiers in Immunology 2014
- Place of Presentation
  Novel Forum,Karolinska Institutet, Stockholm, Sweden
- Year and Date
  2014-06-18 – 2014-06-21
- Data Source
  KAKENHI-PROJECT-25440007
[Presentation] Immunoglobulin gene diversification by activation-induced cytidine deaminase (AID) through Topoisomerase1 (Top1) .
- Author(s)
  Maki Kobayashi, Jianliang Xu, Tasuku Honjo
- Organizer
  The Golden Anniversary of B Cells Discovery, Keystone Symposia
- Place of Presentation
  Fairmont Banff Springs, Banff, Canada
- Year and Date
  2015-03-22 – 2015-03-26
- Data Source
  KAKENHI-PROJECT-25440007

1. BEGUM Nasim (80362507)

# of Collaborated Projects: 5 results

# of Collaborated Products: 3 results
2. HONJO Tasuku (80090504)

# of Collaborated Projects: 4 results

# of Collaborated Products: 10 results
3. SHINKURA Reiko (50362471)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
4. NAGAOKA Hitoshi (20270647)

# of Collaborated Projects: 2 results

# of Collaborated Products: 1 results
5. NISHIKORI Momoko (60378635)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
6. CHON Il-Mi (50452339)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
7. DOI Tomomitsu (70437218)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
8. SUZUKI Norio

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
9. 王継揚

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
10. 廣田耕志

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
11. 小林麻己人

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
12. 森屋恭爾

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
13. 小池和彦

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
14. 新蔵礼子

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
15. 山本雅之

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Kobayashi Maki 小林 牧

KOBAYASHI Maki 小林 牧

Research Projects

Research Products

Co-Researchers

効率的な抗体遺伝子組換えにおける液ー液相分離複合体の重要性の解析Principal Investigator

Principal Investigator

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Molecular mechanism of the AID-recombinosome formation which is essential for vaccine-induced antibody gene diversification

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Transcription-dependent IgH gene instability by RNA interferencePrincipal Investigator

Principal Investigator

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Analysis of the molecular mechanism of IgH gene diversification depending on RNA-editing by AID

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Molecular mechanism of genomic instability by RNA editingPrincipal Investigator

Principal Investigator

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Genomic instability by Topoisomerase 1 induced by AID-dependent RNA editingPrincipal Investigator

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Regulatory mechanism of Topoisomerase1 by small RNA molecules which leads genomic instabilityPrincipal Investigator

Principal Investigator

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Mechanism for genome instability by activation induced cytidine deaminase induced-reduction of topoisomerase1

Principal Investigator

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Research Institution

AID-dependent genetic alteration mechanism to generate antigen-specific antibodies

Principal Investigator

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Research Institution

[Journal Article] Ago2 and a miRNA reduce Topoisomerase 1 for enhancing DNA cleavage in antibody diversification by activation-induced cytidine deaminase2023

Author(s)

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DOI

Data Source

[Journal Article] Necessity of HuR/ELAVL1 for activation-induced cytidine deaminase-dependent decrease in topoisomerase 1 in antibody diversification.2023

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[Journal Article] SAMHD 1‐mediated dNTP degradation is required for efficient DNA repair during antibody class switch recombination2020

Author(s)

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[Journal Article] RNA-binding motifs of hnRNP K are critical for induction of antibody diversification by activation-induced cytidine deaminase2020

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Antibody class switch recombination requires SAMHD1-mediated dNTP degradation to promote DNA repair2020

Kobayashi Maki 小林牧

KOBAYASHI Maki 小林牧