OKUNO Takashi 奥野高司

Researcher Number	20411366
Other IDs
Affiliation (based on the past Project Information) *help	2015: 大阪医科大学, 医学部, 非常勤講師 2014: 大阪医科大学, 医学部, その他 2010 – 2013: 大阪医科大学, 医学部, 非常勤講師 2012: 大阪医科大学, 医学部, その他 2008: Osaka Medical College, 医学部, 非常勤講師 2007: Osaka Medical College, 医学部, 助教 2006: 大阪医科大学, 医学部, 助手
Review Section/Research Field	Principal Investigator Ophthalmology Except Principal Investigator Ophthalmology
Keywords	Principal Investigator in vivo / 5-hydroxydecanoic acid / mitchondria KATP channel / fluorescence activated cell sorting / OGD誘発細胞死 / 神経節細胞 / サル / ウサギ / 視神経萎縮 / 網膜電図 … More / 視覚誘発電位 / 網膜神経節細胞 / 緑内障 / 神経保護 … More Except Principal Investigator 一酸化窒素 / アストロサイト / ラット / 視神経 / aquaporin-9 / aquaporin-4 / グルタミン / TGN-020 / aquaporin 4 / 視神経挫滅 / グルタミン酸 / aquaporin / real time-PCR / endothelin-1 / 活性化グリア細胞 / GFAP / endothelin / iNOS / TNF-α / NF-κB / NFκB / neuro-inflammation / simvastatin / NFκ B / 網膜神経節細胞 / 視神経挫滅モデル / CD68 / スタチン Less

Involvement of aquaporin in the formation of optic nerve edema and protective effects of blocking the AQP channels.
- Principal Investigator
  
  Oku Hidehiro
- Project Period (FY)
  2013 – 2015
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Ophthalmology
- Research Institution
  Osaka Medical College
Determination of neuro-protective effects of statin on the retinal injuries through activated glial cells.
- Principal Investigator
  
  OKU Hidehiro
- Project Period (FY)
  2010 – 2012
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Ophthalmology
- Research Institution
  Osaka Medical College
The neuroprotective effects of diazoxide for the glaucoma model by NMDA and ischemiaPrincipal Investigator
- Principal Investigator
  
  OKUNO Takashi
- Project Period (FY)
  2006 – 2008
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Ophthalmology
- Research Institution
  Osaka Medical College

All 2012 2011 2009 2008 2007 2006

All Journal Article Presentation

[Journal Article] Involvement of glial cells in the autoregulation of optic nerve head blood flow in rabbits.2012
- Author(s)
  Shibata M
- Journal Title
  
  Invest Ophthalmol Vis Sci.
  
  Volume: 53 Issue: 7 Pages: 3726-3732
- DOI
  10.1167/iovs.11-9316
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22591972, KAKENHI-PROJECT-22591973
[Journal Article] Effects of fasudil, a Rho-associated protein kinase inhibitor, on optic nerve head blood flow in rabbits2011
- Author(s)
  Sugiyama T, Shibata M, Kajiura S, et al
- Journal Title
  
  Invest Ophthalmol Vis Sci
  
  Volume: 52 Issue: 1 Pages: 64-69
- DOI
  10.1167/iovs.10-5265
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22591972, KAKENHI-PROJECT-22591973
[Journal Article] Changes in optic nerve head blood flow, visual function, and retinal histology in hyperchol esterolemic rabbits2011
- Author(s)
  Shibata M, Sugiyama T, Hoshiga M, et al
- Journal Title
  
  Exp Eye Res
  
  Volume: 93 Issue: 6 Pages: 818-824
- DOI
  10.1016/j.exer.2011.09.014
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22591972, KAKENHI-PROJECT-22591973
[Journal Article] Disruption of gap junctions may be involved in impairment of autoregulation2011
- Author(s)
  Shibata M, Oku H, Sugiyama T, et al
- Journal Title
  
  Invest Ophthalmol Vis Sci
  
  Volume: 52 Issue: 5 Pages: 2153-2159
- DOI
  10.1167/iovs.10-6605
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22591972, KAKENHI-PROJECT-22591973
[Journal Article] Shift of temporal responsivity curve of pattern reversal visually evoked potentials to lower frequencies in patients after recovery from optic neuritis2009
- Author(s)
  Okuno T, Oku H, Sugasawa J, Utsumi T, Iked T.
- Journal Title
  
  Acta Ophthalmol (in press)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18791307
[Journal Article] Peripheral cone dystrophy in an elderly man2009
- Author(s)
  Okuno T, Oku H, Kurimoto T, Oono S, Ikeda T.
- Journal Title
  
  Clin Experiment Ophthalmol 36
  
  Pages: 897-9
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18791307
[Journal Article] Endothelin-1 (ET-1) causes death of retinal neurons through activation of nitric oxide synthase (NOS) and production of superoxide anion2008
- Author(s)
  Oku H, Fukuhara M, Komori A, Okuno T, Sugiyama T, Ikeda T.
- Journal Title
  
  Exp Eye Res 86
  
  Pages: 118-30
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18791307
[Journal Article] Reduced retinal function in amyloid precursor protein-over-expressing transgenic mice via attenuating glutamate-N-methyl-d-aspartate receptor signaling2008
- Author(s)
  Shimazawa M, Inokuchi Y, Okuno T, Nakajima Y, Sakaguchi G, Kato A, Oku H, Sugiyama T, Kudo T, Ikeda T, Takeda M, Hara H.
- Journal Title
  
  J Neurochem 107
  
  Pages: 279-90
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18791307
[Journal Article] Electroretinographic study of spontaneously diabetic Torii rats2008
- Author(s)
  Takashi Okuno
- Journal Title
  
  Doc Ophthalmol 117
  
  Pages: 191-196
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18791307
[Journal Article] Endothelin-1 (ET-1) is increased in rat retina after crushing optic nerve2008
- Author(s)
  Oku H, Fukuhara M, Kurimoto T, Okuno T, Sugiyama T, Ikeda T.
- Journal Title
  
  Curr Eye Res 33
  
  Pages: 611-20
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18791307
[Journal Article] Electroretinographic study of spontaneously diabetic Torii rats2008
- Author(s)
  Okuno T, Oku H, Sugiyama T, Ikeda T.
- Journal Title
  
  Doc Ophthalmol 117
  
  Pages: 191-6
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18791307
[Journal Article] Angiotensin II receptor blocker inhibits abnormal accumulation of advanced glycation end products and retinal damage in a rat model of type 2 diabetes2007
- Author(s)
  Sugiyama T, Okuno T, Fukuhara M, Oku H, Ikeda T, Obayashi H, Ohta M, Fukui M, Hasegawa G, Nakamura N.
- Journal Title
  
  Exp Eye Res 85
  
  Pages: 406-12
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18791307
[Journal Article] High infusion pressure in conjunction with vitreous surgery alters the morphology and function of the retina of rabbits2007
- Author(s)
  Minami M, Oku H, Okuno T, Fukuhara M, Ikeda T.
- Journal Title
  
  Acta Ophthalmol Scand 85
  
  Pages: 633-9
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18791307
[Journal Article] Abnormalities of visual-evoked potentials and pupillary light reflexes in a family with autosomal dominant occult macular dystrophy.2007
- Author(s)
  Takashi Okuno
- Journal Title
  
  Clin Experiment Ophthalmol 35
  
  Pages: 781-783
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18791307
[Journal Article] Glutamate level in optic nerve head is increased by artificial elevation of intraocular pressure in rabbits.2006
- Author(s)
  Takashi Okuno
- Journal Title
  
  Exp Eye Res. 82(3)
  
  Pages: 465-470
- NAID
  10018257119
- Data Source
  KAKENHI-PROJECT-18791307
[Journal Article] Abnormalities of visual-evoked potentials and pupillary light reflexes in a family with autosomal dominant occult macular dystrophy2006
- Author(s)
  Okuno T, Oku H, Kondo M, Miyake Y, Sugasawa J, Utsumi T, Ikeda T.
- Journal Title
  
  Clin ExperimentOphthalmol 35
  
  Pages: 781-3
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18791307
[Journal Article] Ocular blood flow changes after dynamic exercise in humans2006
- Author(s)
  Takashi Okuno
- Journal Title
  
  Eye 20(7)
  
  Pages: 796-800
- Data Source
  KAKENHI-PROJECT-18791307
[Journal Article] Glutamate level in optic nerve head is increased by artificial elevation of intraocular pressure in rabbits2006
- Author(s)
  Okuno T, Oku H, Sugiyama T, Ikeda T.
- Journal Title
  
  Exp Eye Res 82
  
  Pages: 465-70
- NAID
  10018257119
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18791307
[Journal Article] Ocular blood flow changes after dynamic exercise in humans2006
- Author(s)
  Okuno T, Sugiyama T, Kohyama M, Kojima S, Oku H, Ikeda T.
- Journal Title
  
  Eye 20
  
  Pages: 796-800
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18791307
[Presentation] 低酸素状態における一酸化窒素の神経毒性2009
- Author(s)
  奥英弘、福原雅之、奥野高司、勝村浩三、松尾純子、小嶌祥太、杉山哲也、池田恒彦
- Organizer
  第112回日本眼科学会
- Place of Presentation
  横浜
- Data Source
  KAKENHI-PROJECT-18791307
[Presentation] 最終糖化産物(AGE)による網膜周皮細胞死に対するスタチンの抑制効果2009
- Author(s)
  松尾純子、奥英弘、勝村ちひろ、杉山哲也、神原裕子、小林崇俊、福原雅之、奥野高司、池田恒彦
- Organizer
  第112回日本眼科学会
- Place of Presentation
  横浜
- Data Source
  KAKENHI-PROJECT-18791307
[Presentation] 視神経乳頭循環自動調節能に対するグリア細胞の関与2009
- Author(s)
  柴田真帆,杉山哲也,奥英弘,奥野高司,小林正人,平尾真美,池田恒彦
- Organizer
  第112回日本眼科学会
- Place of Presentation
  横浜
- Data Source
  KAKENHI-PROJECT-18791307
[Presentation] アミロイドβ蛋白質の網膜機能および細胞死に対する影響2008
- Author(s)
  嶋澤雅光,井口勇太,奥野高司,坂口岳,加藤晃,奥英弘,杉山哲也,工藤喬,池田恒彦,武田雅俊,原英彰
- Organizer
  第112回日本眼科学会
- Place of Presentation
  横浜
- Data Source
  KAKENHI-PROJECT-18791307
[Presentation] 網膜神経節細胞株(RGC-5)に対するスタチンの神経保護作用の検討2008
- Author(s)
  奥英弘,勝村浩三,松尾純子,奥野高司,小林崇俊,小嶌祥太,福原雅之,杉山哲也,池田恒彦
- Organizer
  第112回日本眼科学会
- Place of Presentation
  横浜
- Data Source
  KAKENHI-PROJECT-18791307
[Presentation] SDTラット眼内・蛋白糖化最終産物に対するアンジオテンシンII受容体拮薬の作用2007
- Author(s)
  杉山哲也,奥野高司,福原雅之,小森麻子,奥英弘,池田恒彦,太田光煕,尾林博
- Organizer
  第110回日本眼科学会
- Place of Presentation
  大阪
- Data Source
  KAKENHI-PROJECT-18791307
[Presentation] Involvement of Amyloid-β in Retinal Function2007
- Author(s)
  Shimazawa M, Inokuchi Y, Okuno T, Sakaguchi G, Kato A, Sugiyama T, Kudo T, Ikeda T, Takeda M, Hara H.
- Organizer
  79th Annual Meeting of the Association for Research in Vision and Ophthalmology
- Place of Presentation
  Florida, USA.
- Data Source
  KAKENHI-PROJECT-18791307
[Presentation] SDTラットの網膜電図に対するアンジオテンシンII受容体拮抗薬の効果2007
- Author(s)
  奥野高司,奥英弘,杉山哲也,小森麻子,池田恒彦
- Organizer
  第55回日本臨床視覚電気生理学会
- Place of Presentation
  名古屋
- Year and Date
  2007-11-03
- Data Source
  KAKENHI-PROJECT-18791307
[Presentation] ラット視神経挫滅モデルにおける網膜内エンドセリン-1の変化2007
- Author(s)
  奥野高司,奥英弘,福原雅之,杉山哲也,池田恒彦
- Organizer
  第111回日本眼科学会
- Place of Presentation
  大阪
- Data Source
  KAKENHI-PROJECT-18791307
[Presentation] Endothelin-1 (ET-1) Causes Death of Retinal Neurons Through Activation of Nitric Oxide Synthase (NOS) and Production of Superoxide Anion2007
- Author(s)
  Oku H, Fukuhara M, Komori A, Okuno T, Sugiyama T, Ikeda T.
- Organizer
  79th Annual Meeting of the Association for Research in Vision and Ophthalmology
- Place of Presentation
  Florida, USA.
- Data Source
  KAKENHI-PROJECT-18791307
[Presentation] NMDA 誘発網膜内層障害に対するミトコンドリア内膜カリウムチャネル開口薬の効果2007
- Author(s)
  奥野高司,奥英弘,杉山哲也,小森麻子,池田恒彦
- Organizer
  第110回日本眼科学会
- Place of Presentation
  大阪
- Data Source
  KAKENHI-PROJECT-18791307
[Presentation] Temporal frequency changes in the pattern reversal visual evoked potential (PVEP) amplitude in optic neuritis2006
- Author(s)
  Okuno T, Oku H, Sugasawa J, Utsumi T, Ikeda T.
- Organizer
  16th International Neuron-Ophthalmology Society (INOS) Congress
- Place of Presentation
  Tokyo, Japan
- Data Source
  KAKENHI-PROJECT-18791307

1. OKU Hidehiro (90177163)

# of Collaborated Projects: 2 results

# of Collaborated Products: 1 results
2. TAKAI Shinji (80288703)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
3. FUKUHARA Masayuki (00238510)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
4. ISHIZAKI Eisuke (70530434)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
5. KOBAYASHI Takatoshi (10567093)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
6. HARA Hideaki (20381717)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
7. HORIE Taeko

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
8. MORISHITA Seita

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
9. SUGIYAMA Tetsuya (20298764)

# of Collaborated Projects: 1 results

# of Collaborated Products: 3 results
10. KURIMOTO Takuji (50388815)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
11. Ikeda Tsunehiko (70222891)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
12. Kida Teruyo (90610105)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
13. TONARI Masahiro

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
14. Kakurai Keigo

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results

OKUNO Takashi 奥野 高司

Research Projects

Research Products

Co-Researchers

Involvement of aquaporin in the formation of optic nerve edema and protective effects of blocking the AQP channels.

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Determination of neuro-protective effects of statin on the retinal injuries through activated glial cells.

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

The neuroprotective effects of diazoxide for the glaucoma model by NMDA and ischemiaPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] Involvement of glial cells in the autoregulation of optic nerve head blood flow in rabbits.2012

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Effects of fasudil, a Rho-associated protein kinase inhibitor, on optic nerve head blood flow in rabbits2011

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Changes in optic nerve head blood flow, visual function, and retinal histology in hyperchol esterolemic rabbits2011

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Disruption of gap junctions may be involved in impairment of autoregulation2011

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Shift of temporal responsivity curve of pattern reversal visually evoked potentials to lower frequencies in patients after recovery from optic neuritis2009

Author(s)

Journal Title

Data Source

[Journal Article] Peripheral cone dystrophy in an elderly man2009

Author(s)

Journal Title

Data Source

[Journal Article] Endothelin-1 (ET-1) causes death of retinal neurons through activation of nitric oxide synthase (NOS) and production of superoxide anion2008

Author(s)

Journal Title

Data Source

[Journal Article] Reduced retinal function in amyloid precursor protein-over-expressing transgenic mice via attenuating glutamate-N-methyl-d-aspartate receptor signaling2008

Author(s)

Journal Title

Data Source

[Journal Article] Electroretinographic study of spontaneously diabetic Torii rats2008

Author(s)

Journal Title

Data Source

[Journal Article] Endothelin-1 (ET-1) is increased in rat retina after crushing optic nerve2008

Author(s)

Journal Title

Data Source

[Journal Article] Electroretinographic study of spontaneously diabetic Torii rats2008

Author(s)

Journal Title

Data Source

[Journal Article] Angiotensin II receptor blocker inhibits abnormal accumulation of advanced glycation end products and retinal damage in a rat model of type 2 diabetes2007

Author(s)

Journal Title

Data Source

[Journal Article] High infusion pressure in conjunction with vitreous surgery alters the morphology and function of the retina of rabbits2007

Author(s)

Journal Title

Data Source

[Journal Article] Abnormalities of visual-evoked potentials and pupillary light reflexes in a family with autosomal dominant occult macular dystrophy.2007

Author(s)

OKUNO Takashi 奥野高司