FAN Jun 方軍

… Alternative Names

方軍ファンジュン

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Researcher Number	20412736
Other IDs
Affiliation (Current)	2025: 崇城大学, 薬学部, 准教授
Affiliation (based on the past Project Information) *help	2024: 崇城大学, 薬学部, 准教授 2010 – 2022: 崇城大学, 薬学部, 准教授 2005 – 2009: 崇城大学, 薬学部, 講師
Review Section/Research Field	Principal Investigator Medium-sized Section 50:Oncology and related fields / Basic Section 50020:Tumor diagnostics and therapeutics-related / Physical pharmacy / Tumor therapeutics / Clinical oncology Except Principal Investigator Biological Sciences / Basic Section 56040:Obstetrics and gynecology-related / Physical pharmacy
Keywords	Principal Investigator ナノメディシン / ドラッグデリバリー / 一酸化炭素 / EPR効果 / 脂肪代謝 / がん代謝 / 効果増強 / オフターゲットデリバリー / off-target delivery / Off-target delivery … More / RES / Intralipid / Tumor targeting / EPR effect / 腫瘍血流 / イントラリピッド / off-targetデリバリー / 腫瘍 / ヒドロキシウレア / アルギニン / ニトログリセリン / 腫瘍微小環境 / 一酸化窒素 / 腫瘍ターゲティング / DDS / Tumor imaging / プロトポルフィリン / 腫瘍イメージング / 亜鉛プロトポルフィリン / PDT / 光化学療法 … More Except Principal Investigator ナノメディシン / DDS / ZnPP / ナノメディスン / 高分子ポリマー / HPMA-ZnPP / ドラッグデリバリーシステム / PDT / EPR効果 / HPMA / NOの寿命 / PEG化医薬 / NOの寿命延長 / 水可溶化 / 降圧剤 / 徐放性 / XO阻害剤 / ドラッグデリバリー / 腫瘍ターゲティング / 腫瘍ターゲラィング / PEG化制癌剤 / 新しい光化学療法 / Znプロトポルフィリン / 腫瘍ターゲッティング / 高分子型制癌剤 / HO-1阻害剤 / HSP32阻害剤 / SMA-ミセル化制癌剤 / HSP-32 / 光増感療法 / PEG-ZnP(亜鉛プロトポルフィリン) / D-アミノ酸酸化酵素 / HSP32 / HO-1 / オキシストレス誘導 / 腫瘍選択性 / 高分子化製剤 / ミセル化製剤 / EPR-効果 Less

Investigation of the Anticancer Effects of Carbon Monoxide Nanopreparations Targeting Cancer Cell Metabolic ReprogrammingPrincipal Investigator
- Principal Investigator
  
  方軍
- Project Period (FY)
  2024 – 2026
- Research Category
  
  Grant-in-Aid for Challenging Research (Exploratory)
- Review Section
  
  Medium-sized Section 50:Oncology and related fields
- Research Institution
  Sojo University
Augmentation of EPR effect and therapeutic effect of nanomedicine by inhibiting off-targeting deliveryPrincipal Investigator
- Principal Investigator
  
  Fang Jun
- Project Period (FY)
  2019 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 50020:Tumor diagnostics and therapeutics-related
- Research Institution
  Sojo University
Clinical application of photodynamic therapy using HPMA-ZnPP for gynecologic cancer
- Principal Investigator
  
  Shintaro Yanazume
- Project Period (FY)
  2019 – 2021
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 56040:Obstetrics and gynecology-related
- Research Institution
  Kagoshima University
Augmentation of EPR effect and therapeutic effect of nanomedicine by improving tumor microenvironmentPrincipal Investigator
- Principal Investigator
  
  FANG Jun
- Project Period (FY)
  2016 – 2018
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Physical pharmacy
- Research Institution
  Sojo University
Design and evaluation of the theranostic potential of tumor-targeted polymeric micelle of zinc protoporphyrinPrincipal Investigator
- Principal Investigator
  
  FANG Jun
- Project Period (FY)
  2013 – 2015
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Tumor therapeutics
- Research Institution
  Sojo University
Development of zinc protoporphyrin micelles for cancer photodymanic therapy with xenon lightPrincipal Investigator
- Principal Investigator
  
  FANG Jun
- Project Period (FY)
  2010 – 2012
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Clinical oncology
- Research Institution
  Sojo University
Macromolecular anticancer agent, PEGylated Zinc protoporphyrin (ZnP) targeting HSP32
- Principal Investigator
  
  MAEDA Hiroshi
- Project Period (FY)
  2008 – 2009
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  Sojo University
New miceller agent for antioxidation therapy based on XO inhibition using AHPP
- Principal Investigator
  
  MAEDA Hiroshi
- Project Period (FY)
  2008 – 2010
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Physical pharmacy
- Research Institution
  Sojo University
EPR効果に基づく活性酸素生成型高分子薬の固形癌ターゲティング療法
- Principal Investigator
  
  MAEDA Hiroshi
- Project Period (FY)
  2005 – 2007
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  Sojo University

[Book] Nanotechnology in Health Care2012
- Author(s)
  Jun Fang
- Total Pages
  400
- Publisher
  Pan Stanford Publisher
- Data Source
  KAKENHI-PROJECT-22700927
[Book] PEGylated zinc protoporphyrin: a micelle forming polymeric drug for cancer therapy.2012
- Author(s)
  Fang J, Nakamura H, Seki T, Qin H, Bharate GY, Maeda H.
- Publisher
  Nanotechnology in Health Care, Singapore, Pan Stanford Publisher
- Data Source
  KAKENHI-PROJECT-22700927
[Book] Liver tumor targeting In Drug Delivery in Oncology. From Basic Research to Cancer Therapy2011
- Author(s)
  K.Hochdorffer, G.DiStefano, L.Fiume, H.Maeda, F.Kratz
- Publisher
  Wiley-VCH Verlag GmbH & Co.KG, Weinhein, Germany(in press)
- Data Source
  KAKENHI-PROJECT-20590049
[Book] PEGylated Zinc Protoporphyrin : A Micelle Forming Polymeric Drug for Cancer Therapy in Nanotechnology in Health Care (Ed.Sanjeeb Sahoo)2011
- Author(s)
  Jun Fang
- Publisher
  Pan Stanford Publishing Pte Ltd.(In press)
- Data Source
  KAKENHI-PROJECT-22700927
[Book] Pharm. Perspective of Cancers Therapeutics(eds. Y.Lu and R.I.Mahato, Tumor targeted macromolecular drug delivery based on the enhanced permeability and retention effect in solid tumor.)2009
- Author(s)
  T. Seki, J. Fang, H. Maeda
- Publisher
  AAPS Springer Press
- Data Source
  KAKENHI-PROJECT-20015045
[Book] Pharm.Perspective of Cancers Therapeutics (eds.Y.Lu and R.I.Mahato)(Tumor targeted macromolecular drug delivery based on the enhanced permeability and retention effect in solid tumor.)2009
- Author(s)
  T.Seki, J.Fang, H.Maeda
- Publisher
  AAPS Springer Press, New York
- Data Source
  KAKENHI-PROJECT-20590049
[Book] Tumor targeted macromolecular drug delivery based on the enhanced permeability and retention effect in solid tumor. In Pharmaceutical Perspectives of Cancer Therapeutics (eds.Y.Lu and R.I.Mahato)2009
- Author(s)
  T.Seki, J.Fang, H.Maeda
- Total Pages
  27
- Publisher
  AAPS Springer Press, New York
- Data Source
  KAKENHI-PROJECT-20590049
[Book] Tumor targeted macromolecular drug delivery based on the enhanced permeability and retention effect in solid tumor.In Pharmaceutical Perspectives of Cancer Therapeutics(eds.Y.Lu, R.I.Mahato)2009
- Author(s)
  T.Seki, J.Fang, H.Maeda
- Total Pages
  27
- Publisher
  AAPS Springer Press, New York
- Data Source
  KAKENHI-PROJECT-20015045
[Book] Delivery of Protein and Peptide Drugs in Cancer (V. Torchilin)2006
- Author(s)
  K.Greish, A.K.Iyer, J.Fang, M.Kawasuji, H.Maeda
- Publisher
  Imperial College Press, London
- Data Source
  KAKENHI-PROJECT-17016076
[Book] Factors and mechanism of "EPR" effect and clinical outlook of SMANCS. Cancer Chemoprevention and Drug Therapy of the New Millennium (eds.R.Han, Y.Sun)2005
- Author(s)
  H.Maeda, J.Fang, T.Sawa
- Total Pages
  15
- Publisher
  People's Military Medical Press, Beijing
- Data Source
  KAKENHI-PROJECT-17016076
[Book] Use of lipiodol as carrier in cancer target chemotherapy. Cancer Chemoprevention and Drug Therapy of the New Millennium (eds.R.Han and Y.Sun)2005
- Author(s)
  H.Maeda, J.Fang, T.Sawa
- Total Pages
  14
- Publisher
  People's Military Medical Press, Beijing
- Data Source
  KAKENHI-PROJECT-17016076
[Journal Article] HPMA copolymer conjugated 5-aminolevulinic acid exhibits superior efficacy for photodynamic therapy with tumor-responsive and targeting properties.2023
- Author(s)
  Islam R, Kotalik K, Subr V, Gao S, Zhou J-R, Yokomizo K, Etrych T, Fang J.
- Journal Title
  
  Nanomedicine.
  
  Volume: 48 Pages: 102636-102636
- DOI
  10.1016/j.nano.2022.102636
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K07743
[Journal Article] Effect of tumor targeted anthracycline nanomedicine with HPMA copolymer-conjugated pirarubicin (P-THP) against gynecological malignancies2022
- Author(s)
  Shintaro Yanazume, Shintaro Yanazume, Jun Fang, Rayhanul Islam, Shanghui Gao and Hiroaki Kobayashi
- Journal Title
  
  Journal of Personalized Medicine
  
  Volume: -
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K09806
[Journal Article] Factors affecting the dynamics and heterogeneity of the EPR effect: pathophysiological and pathoanatomic features, drug formulations and physicochemical factors.2022
- Author(s)
  Islam R, Maeda H, Fang J.
- Journal Title
  
  Expert Opin Drug Deliv.
  
  Volume: 19(2) Issue: 2 Pages: 199-212
- DOI
  10.1080/17425247.2021.1874916
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K07743
[Journal Article] Polymer-conjugated glucosamine complexed with boric acid shows tumor-selective accumulation and simultaneous inhibition of glycolysis2021
- Author(s)
  Islam Waliul、Matsumoto Yoshitaka、Fang Jun、Harada Ayaka、Niidome Takuro、Ono Katsuhiko、Tsutsuki Hiroyasu、Sawa Tomohiro、Imamura Takahisa、Sakurai Kazuo、Fukumitsu Nobuyoshi、Yamamoto Hirofumi、Maeda Hiroshi
- Journal Title
  
  Biomaterials
  
  Volume: 269 Pages: 120631-120631
- DOI
  10.1016/j.biomaterials.2020.120631
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K07743, KAKENHI-PROJECT-18K07256
[Journal Article] Development of a Selective Tumor-Targeted Drug Delivery System: Hydroxypropyl-Acrylamide Polymer-Conjugated Pirarubicin (P-THP) for Pediatric Solid Tumors.2021
- Author(s)
  Makimoto A, Fang J, Maeda H.
- Journal Title
  
  Cancers
  
  Volume: 13(15) Issue: 15 Pages: 3698-3698
- DOI
  10.3390/cancers13153698
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K07743
[Journal Article] Tumor Environment-Responsive Hyaluronan Conjugated Zinc Protoporphyrin for Targeted Anticancer Photodynamic Therapy2021
- Author(s)
  Gao Shanghui、Islam Rayhanul、Fang Jun
- Journal Title
  
  Journal of Personalized Medicine
  
  Volume: 11 Issue: 2 Pages: 136-136
- DOI
  10.3390/jpm11020136
- Data Source
  KAKENHI-PROJECT-19K07743
[Journal Article] Styrene Maleic Acid Copolymer-Based Micellar Formation of Temoporfin (SMA@ mTHPC) Behaves as A Nanoprobe for Tumor-Targeted Photodynamic Therapy with A Superior Safety2021
- Author(s)
  Jun Fang, Hinata Nema, Rina Yanagibashi, Niho Yoneda, Natsumi Watanabe, Yuki Yasuda, Naoki Nuita, Jian-Rong Zhou, Kazumi Yokomizo
- Journal Title
  
  Biomedicines.
  
  Volume: Oct 19;9(10) Issue: 10 Pages: 1493-1493
- DOI
  10.3390/biomedicines9101493
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K09806, KAKENHI-PROJECT-19K07743
[Journal Article] Expression Dynamics of Heme Oxygenase-1 in Tumor Cells and the Host Contributes to the Progression of Tumors2021
- Author(s)
  Jun Fang, Rayhanul Islam, Shanghui Gao, Cheng Zhang, Ryotaro Kunisaki, Shogo Sakaguchi, Naoya Honda, Jian-Rong Zhou, Kazumi Yokomizo
- Journal Title
  
  Journal of Personalized Medicine
  
  Volume: Dec; 11(12) Issue: 12 Pages: 1340-1340
- DOI
  10.3390/jpm11121340
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K09806, KAKENHI-PROJECT-19K07743
[Journal Article] Unraveling the role of Intralipid in suppressing off-target delivery and augmenting the therapeutic effects of anticancer nanomedicines.2021
- Author(s)
  Islam R, Gao S, Islam W, Subr V, Zhou JR, Yokomizo K, Etrych T, Maeda H, Fang J.
- Journal Title
  
  Acta Biomater.
  
  Volume: 126 Pages: 372-383
- DOI
  10.1016/j.actbio.2021.03.044
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K07743
[Journal Article] Highly effective anti-tumor nanomedicines based on HPMA copolymer conjugates with pirarubicin prepared by controlled RAFT polymerization2020
- Author(s)
  E. Randarova, H. Nakamura, R. Islam, M. Studenovsky, Mamoru Haratake, J. Fang, P. Chytil, T. Etrych
- Journal Title
  
  Acta Biomaterialia
  
  Volume: 106 Pages: 256-266
- DOI
  10.1016/j.actbio.2020.02.011
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K06617, KAKENHI-PROJECT-19K07743
[Journal Article] Exploiting the dynamics of the EPR effect and strategies to improve the therapeutic effects of nanomedicines by using EPR effect enhancers2020
- Author(s)
  Fang Jun、Islam Waliul、Maeda Hiroshi
- Journal Title
  
  Advanced Drug Delivery Reviews
  
  Volume: 157 Pages: 142-160
- DOI
  10.1016/j.addr.2020.06.005
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19K07743
[Journal Article] N-(2-hydroxypropyl)methacrylamide polymer conjugated pyropheophorbide-a, a promising tumor-targeted theranostic probe for photodynamic therapy and imaging.2018
- Author(s)
  Fang J, Subr V, Islam W, Hackbarth S, Islam R, Etrych T, Ulbrich K, Maeda H.
- Journal Title
  
  Eur J Pharm Biopharm.
  
  Volume: 130 Pages: 165-176
- DOI
  10.1016/j.ejpb.2018.06.005
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K08217
[Journal Article] Augmentation of the enhanced permeability and retention effect with nitric oxide-generating agents improves the therapeutic effects of nanomedicines.2018
- Author(s)
  Islam, W., Fang, J., Imamura, T., Etrych, T., Subr, V., Ulbrich K., & Maeda, H.
- Journal Title
  
  Mol. Cancer Therap.
  
  Volume: 17 Issue: 12 Pages: 2643-2653
- DOI
  10.1158/1535-7163.mct-18-0696
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K08741, KAKENHI-PROJECT-16K08217
[Journal Article] A Retrospective 30 Years After Discovery of the EPR Effect of Solid Tumors: Next-Generation Chemotherapeutics and Photodynamic-therapy-Problems, Solutions, Prospects.2016
- Author(s)
  Maeda H, Tsukigawa K, Fang J.
- Journal Title
  
  Microcirculation.
  
  Volume: 23 Issue: 3 Pages: 173-182
- DOI
  10.1111/micc.12228
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-25430162
[Journal Article] Styrene-maleic acid-copolymer conjugated zinc protoporphyrin as a candidate drug for tumor-targeted therapy and imaging.2016
- Author(s)
  Fang J, Tsukigawa K, Liao L, Yin H, Eguchi K, Maeda H.
- Journal Title
  
  J Drug Target.
  
  Volume: 24 Issue: 5 Pages: 399-407
- DOI
  10.3109/1061186x.2015.1077851
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-25430162
[Journal Article] Effect of different chemical bonds in pegylation of zinc protoporphyrin that affects drug release, intracellular uptake, and therapeutic effect in the tumor.2015
- Author(s)
  Tsukigawa K, Nakamura H, Fang J, Otagiri M, Maeda H
- Journal Title
  
  Eur J Pharm Biopharm.
  
  Volume: 89 Pages: 259-270
- DOI
  10.1016/j.ejpb.2014.12.016
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-25670085, KAKENHI-PROJECT-26860031, KAKENHI-PROJECT-25430162
[Journal Article] Enhanced permeability and retention effect based nanomedicine, a solution for cancer2015
- Author(s)
  Fang J.
- Journal Title
  
  World J Pharmcology.
  
  Volume: 4 Issue: 2 Pages: 168-171
- DOI
  10.5497/wjp.v4.i2.168
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-25430162
[Journal Article] Photodynamic therapy and imaging based on tumor-targeted nanoprobe, polymer-conjugated zinc protoporphyrin.2015
- Author(s)
  Fang J, Liao L, Yin H, Nakamura H, Subr V, Ulbrich K, Maeda H.
- Journal Title
  
  Future Sci. OA.
  
  Volume: 1 Issue: 3
- DOI
  10.4155/fso.15.2
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-25430162
[Journal Article] Two step mechanisms of tumor selective delivery of N-(2-hydroxypropyl)methacrylamide copolymer conjugated with pirarubicin via an acid-cleavable linkage.2014
- Author(s)
  Nakamura H, Etrych T, Chytil P, Ohkubo M, Fang J, Ulbrich K, Maeda H.
- Journal Title
  
  J Control Release
  
  Volume: 174C Pages: 81-87
- DOI
  10.1016/j.jconrel.2013.11.011
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-25430162
[Journal Article] Enhanced Bacterial Tumor Delivery by Modulating the EPR Effect and Therapeutic Potential of Lactobacillus casei.2014
- Author(s)
  Fang J, Liao L, Yin H, Nakamura H, Shin T, Maeda H.
- Journal Title
  
  J Pharm Sci.
  
  Volume: 103 Issue: 10 Pages: 3235-43
- DOI
  10.1002/jps.24083
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-25430162, KAKENHI-PROJECT-26860031
[Journal Article] Upregulation of heme oxygenase-1 in colorectal cancer patients with increased circulation carbon monoxide levels, potentially affects chemotherapeutic sensitivity.2014
- Author(s)
  Yin H, Fang J, Liao L, Maeda H, Su Q.
- Journal Title
  
  BMC Cancer.
  
  Volume: 14 Issue: 1 Pages: 436-436
- DOI
  10.1186/1471-2407-14-436
- Open Access
- Data Source
  KAKENHI-PROJECT-25430162
[Journal Article] Styrene-maleic acid copolymer-encapsulated CORM2, a water-soluble carbon monoxide (CO) donor with a constant CO-releasing property, exhibits therapeutic potential for inflammatory bowel disease.2014
- Author(s)
  Yin H, Fang J, Liao L, Nakamura H, Maeda H.
- Journal Title
  
  J Control Release.
  
  Volume: 187 Pages: 14-21
- DOI
  10.1016/j.jconrel.2014.05.018
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-25430162, KAKENHI-PROJECT-26860031
[Journal Article] Micelles of zinc protoporphyrin conjugated to N-(2-hydroxypropyl)2013
- Author(s)
  Nakamura H, Liao L, Hitaka Y, Tsukigawa K, Subr V, Fang J, Ulbrich K, Maeda H.
- Journal Title
  
  J Control Release
  
  Volume: 165 Issue: 3 Pages: 191-198
- DOI
  10.1016/j.jconrel.2012.11.017
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22700927, KAKENHI-PROJECT-25430162
[Journal Article] Improvement of tumor uptake, lowering of systemic toxicity, and distinct tumor imaging in vivo.2013
- Author(s)
  Maeda H, Nakamura H, Fang J. The EPR effect for macromolecular drug delivery to solid tumors
- Journal Title
  
  Adv Drug Deliv Rev.
  
  Volume: 65 Issue: 1 Pages: 71-79
- DOI
  10.1016/j.addr.2012.10.002
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22700927, KAKENHI-PROJECT-25430162
[Journal Article] Protection from inflammatory bowel disease and colitis-associated carcinogenesis with 4-vinyl-2,6-dimethoxyphenol (canolol) involve suppression of oxidative stress and inflammatory cytokines.2013
- Author(s)
  Fang J, Seki T, Tsukamoto T, Qin H, Yin H, Liao L, Nakamura H, Maeda H.
- Journal Title
  
  Carcinogenesis
  
  Volume: 34 Issue: 12 Pages: 2833-2841
- DOI
  10.1093/carcin/bgt309
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-25430162
[Journal Article] HSP32 (HO-1) inhibitor, copoly(styrene maleic acid)-zinc protoporphyrin IX, a water soluble micelle as anticancer agent: in vitro and in vivo anticancer effect.2012
- Author(s)
  Fang J, Greish K, Qin H, Liao L, Nakamura H, Takeya M, Maeda H.
- Journal Title
  
  Eur J
  
  Volume: 81 Issue: 3 Pages: 540-547
- DOI
  10.1016/j.ejpb.2012.04.016
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22700927
[Journal Article] HSP32 (HO-1) inhibitor, zinc protoporphyrin IX, a water soluble micelle of copoly (styrene maleic acid) as anticancer agent : in vitro and in vivo anticancer effect2012
- Author(s)
  Jun Fang, et al
- Journal Title
  
  Eur J Pharm.Biopharm.
  
  Volume: (in press)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22700927
[Journal Article] Intracellular uptake and behavior of two types zinc protoporphyrin (ZnPP) micelles, SMA-ZnPP and PEG-ZnPP as anticancer agents ; Unique intracellular disintegration of SMA micelles2011
- Author(s)
  H.Nakamura, J.Fang, B.Gahininath, K.Tsukigawa, H.Maeda
- Journal Title
  
  J.Controlled Release
  
  Volume: (accepted)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20590049
[Journal Article] Intracellular uptake and behavior of two types zinc protoporphyrin (ZnPP) micelles, SMA-ZnPP and PEG-ZnPP as anticancer agents; Unique intracellular disintegration of SMA micelles.2011
- Author(s)
  Nakamura H, Fang J, Bharate G, Tsukigawa K, Maeda H.
- Journal Title
  
  J Control Release
  
  Volume: 155 Pages: 367-375
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22700927
[Journal Article] The EPR effect: Unique features of tumor blood vessels for drug delivery, factors involved, and limitations and augmentation of the effect.2011
- Author(s)
  Fang J, Nakamura H, Maeda H.
- Journal Title
  
  Adv Drug Deliv Rev
  
  Volume: 63 Issue: 3 Pages: 136-151
- DOI
  10.1016/j.addr.2010.04.009
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22700927
[Journal Article] Intracellular uptake and behavior of two types zinc protoporphyrin (ZnPP) micelles, SMA-ZnPP and PEG-ZnPP as anticancer agents ; Unique intracellular disintegration of SMA micelles2011
- Author(s)
  Hideaki Nakamura, Jun Fang, et al
- Journal Title
  
  J Control Release
  
  Volume: 155 Issue: 3 Pages: 367-375
- DOI
  10.1016/j.jconrel.2011.04.025
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22700927
[Journal Article] EPR effect : the unique characteristics of tumor blood vessels for drug delivery, factors involved, its limitation and augmentation2011
- Author(s)
  J.Fang, H.Nakamura, H.Maeda
- Journal Title
  
  Advanced Drug Delivery Reviews
  
  Volume: (available online)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20590049
[Journal Article] Intracellular uptake and behavior of two types zinc protoporphyrin (ZnPP) micelles, SMA-ZnPP and PEG-ZnPP as anticancer agents ; Unique intracellular disintegration of SMA micelles2011
- Author(s)
  H.Nakamura, J.Fang, B.Gahininath, K.Tsukigawa, H.Maeda
- Journal Title
  
  J.Controlled Release (accepted)
- Data Source
  KAKENHI-PROJECT-20590049
[Journal Article] EPR effect : the unique characteristics of tumor blood vessels for drug delivery, factors involved, its limitation and augmentation2010
- Author(s)
  J.Fang, H.Nakamura, H.Maeda
- Journal Title
  
  Adv.Drug Delivery Reviews (in press)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20015045
[Journal Article] Tissue protective effect of xanthine oxidase inhibitor, polymer conjugate SMA-AHPP, on hepatic ischemia-reperfusion injury2010
- Author(s)
  J.Fang, T.Seki, H.Qin, G.Y.Bharate, A.K.Iyer, H.Maeda
- Journal Title
  
  Exp.Biol.Medicine 235
  
  Pages: 487-496
- Data Source
  KAKENHI-PROJECT-20590049
[Journal Article] Tissue protective effect of xanthine oxidase inhibitor, polymer conjugate SMA-AHPP, on hepatic ischemia-reperfusion injury2010
- Author(s)
  J.Fang, T.Seki, H.Qin, G.Y.Bharate, A.K.Iyer, H.Maeda
- Journal Title
  
  Experimental Biology and Medicine
  
  Volume: 235 Pages: 487-496
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20590049
[Journal Article] Tissue protective effect of xanthine oxidase inhibitor, polymer conjugate SMA-AHPP, on hepatic ischemia-reperfusion injury2010
- Author(s)
  J.Fang, T.Seki, H.Qin, G.Y.Bharate, A.K.Iyer, H.Maeda
- Journal Title
  
  Exp.Biol.and Medicine Available online(Available online)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20590049
[Journal Article] Tissue protective effect of xanthine oxidase inhibitor, polymer conjugate SMA-AHPP, on hepatic ischemia-reperfusion injury2010
- Author(s)
  J. Fang(1/6番目), T. Seki, et al, H. Maeda(6/6番目)
- Journal Title
  
  Exp. Biol. Med. 235
  
  Pages: 487-496
- Data Source
  KAKENHI-PROJECT-20015045
[Journal Article] EPR effect: the unique characteristics of tumor blood vessels for drug delivery, factors involved, its limitation and augmentation2010
- Author(s)
  J. Fang, H. Nakamura, H. Maeda
- Journal Title
  
  Adv. Drug Deliv. Rev. (in press)
- Data Source
  KAKENHI-PROJECT-20015045
[Journal Article] Tissue protective effect of xanthine oxidase inhibitor, polymer conjuga to SMA-AHPP, on hepatic ischemia-reperfusion injury2010
- Author(s)
  J.Fang, T.Seki, H.Qin, G.Y.Bharate, A.K.Iyer, H.Maeda
- Journal Title
  
  Exp.Biol.Medicine (available online)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20015045
[Journal Article] SMA-copolymer conjugate of AHPP : a polymeric inhibitor of xanthine oxidase with potential antihypertensive effect2009
- Author(s)
  J. Fang, 他
- Journal Title
  
  Journal of Controlled Release 135
  
  Pages: 211-217
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20590049
[Journal Article] Enhanced delivery of macromolecular antitumor drugs to tumors by nitroglycerin application2009
- Author(s)
  T. Seki J. Fang, H. Maeda
- Journal Title
  
  Cancer Science 100
  
  Pages: 2426-2430
- NAID
  10027198725
- Data Source
  KAKENHI-PROJECT-20015045
[Journal Article] Therapeutic strategies by modulating oxygen stress in cancer and inflammation2009
- Author(s)
  J.Fang, 他
- Journal Title
  
  Adv. Drug Delivery Reviews 61
  
  Pages: 290-302
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20015045
[Journal Article] SMA-copolymer conjugate of AHPP : a polymeric inhibitor of xanthineoxidase with potential antihyper tensive effect2009
- Author(s)
  J.Fang, A.K.Iyer, H.Nakamura, T.Seki, K.Greish, H.Maeda
- Journal Title
  
  J.Cont.Release 135
  
  Pages: 211-217
- Data Source
  KAKENHI-PROJECT-20590049
[Journal Article] Therapeutic strategies by modulating oxygen stress in cancer and inflammation2009
- Author(s)
  J.Fang T.Seki, H.Maeda
- Journal Title
  
  Advanced Drug Delivery Reviews 61
  
  Pages: 290-302
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20590049
[Journal Article] SMA-copolymer conjugate of AHPP : a polymeric inhibitor of xanthine oxidase with potential antihypertensive effect2009
- Author(s)
  J.Fang, A.K.Iyer, H.Nakamura, T.Seki, K.Greish, H.Maeda
- Journal Title
  
  Journal of Controlled Release 135
  
  Pages: 211-217
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20590049
[Journal Article] Enhanced delivery of macromolecular antitumor drugs to tumors by nitroglyicerin application2009
- Author(s)
  T.Seki J.Fang, H.Maeda
- Journal Title
  
  Cancer Science 100
  
  Pages: 2426-2430
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20015045
[Journal Article] Oxystress indusing antitumor therapeutics via tumor-targeted delivery of PEG-conjugated D-amino acid oxidase.2008
- Author(s)
  J. Fang(1/8番目), H. Nakamura(3/8番目), et al, H. Maeda(8/8番目)
- Journal Title
  
  Int. J. Cancer 122
  
  Pages: 1135-1144
- Data Source
  KAKENHI-PROJECT-20015045
[Journal Article] Oxystress inducing antitumor therapeutics via tumor-targeted delivery of PEG-conjugated D-amino acid oxidase2008
- Author(s)
  J. Fang, 他
- Journal Title
  
  International Journal of Cancer 122
  
  Pages: 1135-1144
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20015045
[Journal Article] Oxystress indusing antitumor therapeutics via tumor-targeted delivery of PEG-conjugated d-amino acid oxidase.2008
- Author(s)
  J. Fang, D. Deng, H. Nakamura, T. Akuta, H. Quin, A. Iyer, K. Greish, H. Maeda
- Journal Title
  
  Int. J. Cancer 122
  
  Pages: 1135-1144
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17016076
[Journal Article] Tumor-targeted induction of oxystress for cancer therapy.2007
- Author(s)
  J. Fang, H. Nakamura & A.K.
- Journal Title
  
  J Drug Targeting 15
  
  Pages: 475-486
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17016076
[Journal Article] Polymeric micelles of zinc protorphyrin for tumor targeted delivery based on EPR effect and singlet oxygen generation.2007
- Author(s)
  A k lyer, k. Grish, T. SEki, S. Okazaki, J. Fang, K. TAkeshita and H. Maeda.
- Journal Title
  
  J Drug Targeting 15
  
  Pages: 496-506
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17016076
[Journal Article] Oxystress inducing antitumor therapeutics via tumor-targeted delivery of PEG-conjugated D-amino acid oxidase2007
- Author(s)
  J.Fang, D.Deng, H.Nakamura, T.Akuta, A.K.Iyer, K.Greish, H.Maeda
- Journal Title
  
  Int J Cancer (in press)
- Data Source
  KAKENHI-PROJECT-17016076
[Journal Article] High-loading nanosized micelles of copoly(styrene-maleic acid)-zinc protoporphyrin for targeted delivery of a potent heme oxygenase inhibitor.2007
- Author(s)
  A.K.Iyer, K.Greish, J.Fang, R.Murakami, H.Maeda
- Journal Title
  
  Biomaterials 28
  
  Pages: 1871-1881
- Data Source
  KAKENHI-PROJECT-17016076
[Journal Article] Exploiting EPR-effect for tumor targeting : principle, mechanism and examples2006
- Author(s)
  A.K.Iyer, G.Khaled, J.Fang, H.Maeda
- Journal Title
  
  Drug Discovery Today 11
  
  Pages: 812-818
- Data Source
  KAKENHI-PROJECT-17016076
[Journal Article] Copoly (styrene-maleic-acid)-pirarubicin micelles : high tumor targeting efficacy with low toxicity2005
- Author(s)
  K.Greish, J.Fang, H.Maeda, et al.
- Journal Title
  
  Bioconj.Chem. 16
  
  Pages: 230-236
- Data Source
  KAKENHI-PROJECT-17016076
[Journal Article] Polymeric xanthine oxidase inhibitor with antiinflammatory and antihypertensive properties : PEG-conjugated micelle of 4-amino-6-hydroxypyrazolo [3,4-d] pyrimidine (AHPP)
- Author(s)
  G.Y.Bharate, J.Fang, H.Nakamura, K.Nakahara, T.Yamaguchi, S.Shinkai, H.Maeda
- Journal Title
  
  J.Drug Targeting (in preparation)
- Data Source
  KAKENHI-PROJECT-20590049
[Patent] 抗炎症剤2008
- Inventor(s)
  前田浩、方軍、関孝弘、バラテガヒナシ
- Industrial Property Rights Holder
  前田浩、方軍、関孝弘、バラテガヒナシ
- Industrial Property Number
  2008-176397
- Filing Date
  2008-07-05
- Data Source
  KAKENHI-PROJECT-20590049
[Presentation] Effect of tumor targeted anthracycline nanomedicine with HPMA copolymer-conjugated pirarubicin (P-THP) against gynecological malignancies2022
- Author(s)
  Shintaro Yanazume, Shintaro Yanazume, Jun Fang, Rayhanul Islam, Shanghui Gao and Hiroaki Kobayashi
- Organizer
  第60回日本癌治療学会学術集会
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K09806
[Presentation] Investigating the anticancer potential of the SMA micelle encapsulating active sulfur-containing compound, Garlicin B12022
- Author(s)
  Shanghui Gao, Jun Fang
- Organizer
  第81回日本癌学会学術総会
- Data Source
  KAKENHI-PROJECT-19K07743
[Presentation] HPMA polymer conjugated pyropheophorbide-a, an acidic pH responsive nanoprobe for tumor-targeted photodynamic therapy2021
- Author(s)
  Rayhanul Islam, Hiroshi Maeda, Jun Fang
- Organizer
  第80回日本癌学会
- Data Source
  KAKENHI-PROJECT-19K07743
[Presentation] Tumor environment-responsive nanoprobe HPMA polymer conjugated pyropheophorbide a for tumor-targeted photodynamic therapy2021
- Author(s)
  Rayhanul Islam, Marina R. Tavares, Vladimir Subr, Tomas Etrych, Hiroshi Maeda, Jun Fang
- Organizer
  第37回日本DDS学会
- Data Source
  KAKENHI-PROJECT-19K07743
[Presentation] Suppression of off-target delivery of nano-drugs and augmentation of therapeutic effect of nanomedicine by Intralipid2020
- Author(s)
  Rayhanul Islam, Waliul Islam, 前田　浩, 方　軍
- Organizer
  第36回日本DDS学会
- Data Source
  KAKENHI-PROJECT-19K07743
[Presentation] Polymer conjugated glucosamine complexed with boric acid with tumor selective accumulation and simultaneous inhibition of glycolysis2020
- Author(s)
  Waliul Islam, 松本孔貴, 原田彩花, 方　軍, 澤智裕, 新留琢郎, 福光延吉, 前田　浩
- Organizer
  第36回日本DDS学会
- Data Source
  KAKENHI-PROJECT-19K07743
[Presentation] Suppression of off-target delivery of nano-drugs and augmentation of therapeutic effect of nanomedicine by Intralipid2020
- Author(s)
  Rayhanul Islam, Waliul Islam, Hiroshi Maeda, Jun Fang
- Organizer
  日本薬学会第140年会
- Data Source
  KAKENHI-PROJECT-19K07743
[Presentation] Suppression of off-target delivery of nanomedicine and augmentation of therapeutic effect of nanomedicine by Intralipid2020
- Author(s)
  Rayhanul Islam, Waliul Islam, 前田　浩, 方　軍
- Organizer
  第79回日本癌学会
- Data Source
  KAKENHI-PROJECT-19K07743
[Presentation] Improving therapeutic effect of nanomedicine by EPR enhancers.2019
- Author(s)
  Jun Fang, Waliul Islam, Rayhanul Islam, Vladimir Subr, Tomas Etrych, Karel Ulbrich, Hiroshi Maeda
- Organizer
  83th Prague Meeting on Macromolecules
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K07743
[Presentation] Polymeric pyropheophorbide-a, a promising tumor-targeted theranostic probe for photodynamic therapy and imaging2019
- Author(s)
  Jun Fang, Vladimir Subr, Waliul Islam, Steffen Hackbarth, Rayhanul Islam, Takuro Niidome, Tomas Etrych, Karel Ulbrich, Hiroshi Maeda
- Organizer
  The 46th Annual Meeting and Exposition of the Controlled Release Society
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K07743
[Presentation] Augmentation of EPR effect and therapeutic efficacy of nanomedicine by carbon monoxide generating agents2019
- Author(s)
  Jun Fang, Rayhanul Islam, Waliul Islam, Hiroshi Maeda
- Organizer
  第７8回日本癌学会
- Data Source
  KAKENHI-PROJECT-19K07743
[Presentation] 一酸化炭素産生薬を用いるEPR効果増強法の検討2019
- Author(s)
  方　軍, Rayhanul Islam, Waliul Islam, Vladimir Subr, 前田　浩
- Organizer
  第３５回日本DDS学会
- Data Source
  KAKENHI-PROJECT-19K07743
[Presentation] Polymeric pyropheophorbide-a, a promising tumor-targeted theranostic probe for photodynamic therapy and imaging.2018
- Author(s)
  Jun Fang, Waliul Islam, Hiroshi Maeda.
- Organizer
  77th Annual Meeting of the Japanese Cancer Association.
- Data Source
  KAKENHI-PROJECT-16K08217
[Presentation] がんセラノスティックスを目指したHPMAポリマー結合型Pyropheophorbide-aの開発2018
- Author(s)
  方　軍、Vladimr Subr、Waliul Md. Islam、Steffen Hackbarth、Tomas Etrych、Karel Ulbrich、前田　浩
- Organizer
  第34回日本DDS学会
- Data Source
  KAKENHI-PROJECT-16K08217
[Presentation] N-(2-Hydroxypropyl)methacrylamide polymer conjugated pyropheophorbide-a, a promising tumor-targeted theranostic probe for photodynamic therapy and imaging.2018
- Author(s)
  Jun Fang, Vladimr Subr, Waliul Islam, Steffen Hackbarth, Tomáš Etrych, Karel Ulbrich, Hiroshi Maeda.
- Organizer
  International Conference on Medicinal Chemistry & Drug Design.
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K08217
[Presentation] Nitric oxide generating agents enhance tumor-targeted photodynamic therapy by modulating tumor microenvironment2017
- Author(s)
  Jun Fang, Waliul Md. Islam, Hiroshi Maeda
- Organizer
  第76回日本癌学会
- Data Source
  KAKENHI-PROJECT-16K08217
[Presentation] Augmentation of tumor-targeted PDT by using nitric oxide generating agents.2017
- Author(s)
  Jun Fang
- Organizer
  International symposium of polymer therapeutics focusing the EPR effect and its Future Development
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K08217
[Presentation] Augmentation of tumor-targeted photodynamic therapy and imaging by modulating tumor microenvironment using nitric oxide generating agents.2017
- Author(s)
  Jun Fang, Waliul Md. Islam, Vladmimir Subr, Tomas Etrych, Karel Ulbrich, Hiroshi Maeda.
- Organizer
  The 44th Annual Meeting and Exposition of the Controlled Release Society
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K08217
[Presentation] Characterization and evaluation of photodynamic effect of HPMA copolymer based nanoprobes.2017
- Author(s)
  Jun Fang, Waliul Islam, Vladmimir Subr, Karel Ulbrich, Hiroshi Maeda
- Organizer
  Trilateral, Japan-Israel-Czech Republic, International Symposium of Polymer Therapeutics Focusing on the Targeted Nanomedicines
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K08217
[Presentation] 一酸化窒素産生薬を用いるEPR効果増強法の検討2017
- Author(s)
  方軍、Waliul Islam、Tomas Etrych、Petr Chytil、Karel Ulbrich、前田浩
- Organizer
  第33回日本DDS学会
- Data Source
  KAKENHI-PROJECT-16K08217
[Presentation] Photodynamic therapy and imaging based on tumor-targeted nanoprobe, pHPMA-conjugated zinc protoporphyrin, and its augmentation.2016
- Author(s)
  Jun Fang, Hideaki Nakamura, Vladmimir Subr, Karel Ulbrich, Hiroshi Maeda.
- Organizer
  International Conference on Pharmaceutical Chemistry
- Place of Presentation
  Frankfurt, Germany
- Year and Date
  2016-09-05
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K08217
[Presentation] Photodynamic therapy and imaging based on tumor-targeted nanoprobe, pHPMA-conjugated zinc protoporphyrin, and its augmentation.2016
- Author(s)
  Jun Fang, Hideaki Nakamura, Vladmimir Subr, Karel Ulbrich, Hiroshi Maeda.
- Organizer
  11th International Symposium on Polymers Therapeutics From Laboratory to Clinical Practice.
- Place of Presentation
  The Centro de Investigacion Principe Felipe (CIPF), Valencia, Spain
- Year and Date
  2016-05-23
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K08217
[Presentation] Photodynamic therapy and imaging based on tumor-targeted nanoprobe, pHPMA-conjugated zinc protoporphyrin, and its augmentation.2015
- Author(s)
  Jun Fang, Hideaki Nakamura, Vladmimir Subr, Karel Ulbrich, Hiroshi Maeda.
- Organizer
  Symposium of 30 Years Anniversary of the EPR Effect: Revolution in Tumor Drug Delivery using Nanomedicine.
- Place of Presentation
  Changchun, P.R.China
- Year and Date
  2015-11-23
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-25430162
[Presentation] 腫瘍標的型亜鉛プロトポルフィリンP-HPMAミセルを用いる癌光化学治療とイメージング2015
- Author(s)
  方　軍、寥　龍、中村　秀明、Vladimir Subr、Karel Ulbrich、前田　浩
- Organizer
  第３１回日本DDS学会
- Place of Presentation
  京王プラザホテル（東京都、新宿区）
- Year and Date
  2015-07-02
- Data Source
  KAKENHI-PROJECT-25430162
[Presentation] Photodynamic therapy and imaging based on tumor-targeted nanoprobe, pHPMA-conjugated zinc protoporphyrin, and its augmentation2015
- Author(s)
  Jun Fang, Hideaki Nakamura, Vladmimir Subr, Karel Ulbrich, Hiroshi Maeda.
- Organizer
  International conference on Clinical Sciences and Drug Discovery (CSDD-2015)
- Place of Presentation
  Baltimore, MA, USA
- Year and Date
  2015-11-02
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-25430162
[Presentation] Preparation of a water soluble carbon monoxide donor, SMA-CORM2 micelles, and therapeutic potential for inflammatory bowel diseases.2014
- Author(s)
  Jun Fang, Haibo Qin, Hongzhuan Yin, Hideaki Nakamura, Hiroshi Maeda.
- Organizer
  The 40th Annual Meeting and Exposition of the Controlled Release Society
- Place of Presentation
  Hawaii Convention Center, Honolulu, Hawaii, U.S.A.
- Data Source
  KAKENHI-PROJECT-25430162
[Presentation] The EPR effect and beyond for cancer selective drug delivery and imaging.2013
- Author(s)
  Maeda H, Nakamura H, Tsukigawa K, Fang J.
- Organizer
  ICBS2013 in Tsukuba.
- Place of Presentation
  Tsukuba, Japan
- Data Source
  KAKENHI-PROJECT-22700927
[Presentation] Evaluation of the targeted photodynamic therapeutic effect of HPMA-zinc protoporphyrin micelle in different tumor models.2013
- Author(s)
  Jun Fang, Long Liao, Hongzhuan Yin, Hideaki Nakamura, Hiroshi Maeda.
- Organizer
  第７２回日本癌学会
- Place of Presentation
  神奈川県、横浜市、パシフィコ横浜
- Data Source
  KAKENHI-PROJECT-25430162
[Presentation] 水溶性DDS型COドナーSMAミセルの作製とその抗炎症作用2013
- Author(s)
  方　軍、殷　紅専、寥　龍、中村　秀明、前田　浩
- Organizer
  第２９回日本DDS学会
- Place of Presentation
  京都府、京都市、京都テルサ
- Data Source
  KAKENHI-PROJECT-25430162
[Presentation] Tumor targeted imaging and photodynamic therapy by HPMA-polymer conjugated Zn-protophyrin micelle.2012
- Author(s)
  Fang J, Nakamura H, Qin H, Subr V, Hitaka Y, Ulbrich K, Maeda H.
- Organizer
  71thAnnual Meeting of the Japanese Cancer Association.
- Place of Presentation
  Sapporo, Japan 1247815KA003 Nakamura H, Liao L, Subr V, Hitaka Y, Tsukigawa K, Fang J, Ulbrich K, Maeda H.
- Data Source
  KAKENHI-PROJECT-22700927
[Presentation] Tumor targeted imaging and photodynamic therapy by HPMA-polymer conjugated Zn-protophyrin micelle.2012
- Author(s)
  Jun Fang
- Organizer
  第７１回日本癌学会
- Place of Presentation
  札幌
- Data Source
  KAKENHI-PROJECT-22700927
[Presentation] The EPR effect as seen by tumor imaging of fluorescent proteins and synthetic nanoparticles.2012
- Author(s)
  Maeda H, Nakamura H, Qin H, Tsukigawa K, Fang J.
- Organizer
  9th International Symposium on Polymer Therapeutics.
- Place of Presentation
  Valencia, Spain
- Data Source
  KAKENHI-PROJECT-22700927
[Presentation] Stability of PEG-zinc protoporphyrin (PEG-ZnPP) and the improved intracellular uptake by cleavage of PEG chains in tumor site2011
- Author(s)
  Kenji Tsukigawa, Hideaki Nakamura, Jun Fang, et al
- Organizer
  第27回日本DDS学会
- Place of Presentation
  東京
- Year and Date
  2011-06-10
- Data Source
  KAKENHI-PROJECT-22700927
[Presentation] Evaluation of (styrene-co-maleic acid) telomer micelles encapsulated-zinc protoporphyrin (SMA-ZnPP) : A stability study for three different types of SMA micelles2011
- Author(s)
  G.Y.Bharate, H.Nakamura, J.Fang, B.Klumperman, S.Shinkai, H.Maeda
- Organizer
  International Conference on Biomaterials Science 2011
- Place of Presentation
  つくば市(茨城県)
- Year and Date
  2011-03-17
- Data Source
  KAKENHI-PROJECT-20590049
[Presentation] The importance of cleavage of PEG chains from pegylated zinc protoporphyrin (PEG-ZnPP) by tumor proteases on intracellular uptake.2011
- Author(s)
  Tsukigawa K, Nakamura H, Fang J, Shinkai S, Maeda H.
- Organizer
  The 38th Annual Meeting and Exposition of the Controlled Release Society.
- Place of Presentation
  National Harbor, Maryland, USA
- Data Source
  KAKENHI-PROJECT-22700927
[Presentation] Evaluation of (styrene-co-maleicacid) telomer micelles encapsulated-zinc protoporphyrin (SMA-ZnPP) : A stability study for three different types of SMA micelles2011
- Author(s)
  G.Y.Bharate, H.Nakamura, J.Fang, B.Klumperman, S.Shinkai, H.Maeda
- Organizer
  International Conference on Biomaterials Science 2011
- Place of Presentation
  茨城県(つくば市)
- Year and Date
  2011-03-17
- Data Source
  KAKENHI-PROJECT-20590049
[Presentation] The importance of cleavage of PEG chains from pegylated zinc protoporphyrin (PEG-ZnPP) by tumor proteases on intracellular uptake2011
- Author(s)
  Kenji Tsukigawa, Hideaki Nakamura, Jun Fang, et al
- Organizer
  The 38th Annual Meeting and Exposition of the Controlled Release Society
- Place of Presentation
  National Harbor, MD, U.S.A
- Year and Date
  2011-08-03
- Data Source
  KAKENHI-PROJECT-22700927
[Presentation] Nanopa rticles of styrene-co-maleic acid (SMA) telomer containing anthracyclin and zinc-protoporphyrin (ZnPP) as new miceller anticancer agents, and SMA conjugate of AHPP, a xanthine oxidase inhibitor for oxystress diseases <Review>2011
- Author(s)
  H.Maeda, H.Nakamura, G.Y.Bharate, K.Tsukigawa, H.Qin, J.Fang
- Organizer
  International Conference on Biomaterials Science 2011
- Place of Presentation
  茨城県(つくば市)
- Year and Date
  2011-03-17
- Data Source
  KAKENHI-PROJECT-20590049
[Presentation] Nanoparticles of styrene-co-maleic acid (SMA) telomer containing anthracyclin and zinc-protoporphyrin (ZnPP) as new miceller anticancer agents, and SMA conjugate of AHPP, a xanthine oxidase inhibitor for oxystress diseases2011
- Author(s)
  H.Maeda, H.Nakamura, G.Y.Bharate, K.Tsukigawa, H.Qin, J.Fang
- Organizer
  International Conference on Biomaterials Science 2011
- Place of Presentation
  つくば市(茨城県)(Review)
- Year and Date
  2011-03-17
- Data Source
  KAKENHI-PROJECT-20590049
[Presentation] Nitroglycerin facilitates tumor drug delivery via augmentation of vascular permeability involving NO generation in the hypoxic tumor tissue2010
- Author(s)
  H.Maeda, H.Nakamura, J.Fang
- Organizer
  The 6th International Conference on the Biology, Chemistry, and Therapeutic Applications of Nitric Oxide
- Place of Presentation
  京都
- Year and Date
  2010-06-17
- Data Source
  KAKENHI-PROJECT-20590049
[Presentation] Limitations and augmentations of the EPR effect in solid tumor2010
- Author(s)
  H.Maeda, H.Nakamura, J.Fang
- Organizer
  8^<th> Int'l Symposium Polymer Therapeutic
- Place of Presentation
  バレンシア(スペイン)
- Year and Date
  2010-05-26
- Data Source
  KAKENHI-PROJECT-20590049
[Presentation] Intracellular uptake of water-soluble ZnPP micelles (SMA-ZnPP and PEG-ZnPP) and the unique release mechanism of the drug from their micelles.2010
- Author(s)
  Nakamura H, Qin H, Bharate GY, Tsukigawa K, Fang J, Maeda H.
- Organizer
  The 37th Annual Meeting and Exposition of the Controlled Release Society.
- Place of Presentation
  Portland, USA
- Data Source
  KAKENHI-PROJECT-22700927
[Presentation] Pegylated hemin, a water-soluble micelle with therapeutic potential against ischemia-reperfusion injury via induction of heme oxygenase-12010
- Author(s)
  方軍
- Organizer
  Annual Meeting of Controlled Release Society 2010
- Place of Presentation
  Oregon Convention Center, Portland, Oregon, USA
- Year and Date
  2010-07-12
- Data Source
  KAKENHI-PROJECT-22700927
[Presentation] Limitations and augmentations of the EPR effect in solid tumor2010
- Author(s)
  H.Maeda, H.Nakamura, J.Fang
- Place of Presentation
  スペイン(バレンシア)
- Year and Date
  2010-05-26
- Data Source
  KAKENHI-PROJECT-20590049
[Presentation] ニトロ剤による腫瘍デリバリーの増強とその臨床成績、基礎2010
- Author(s)
  前田浩、方軍、中村秀明、J.Daruwalla
- Organizer
  第26回日本DDS学会
- Place of Presentation
  大阪
- Year and Date
  2010-06-18
- Data Source
  KAKENHI-PROJECT-20590049
[Presentation] SMA-copolymer conjugates of AHPP : a polymeric inhibitor of xanthine oxidase with therapeutic potentials against hypertension2009
- Author(s)
  方軍
- Organizer
  36th Annual Meeting & Exposition of the Controlled Release Society
- Place of Presentation
  Bella Center(デンマークコペンハーゲン)
- Year and Date
  2009-07-18
- Data Source
  KAKENHI-PROJECT-20590049
[Presentation] ニトログリセリン軟膏塗布による癌局所への高分子制癌剤のEPR効果増強に基づくデリバリーと治療効果の増強2009
- Author(s)
  関孝弘、方軍、前田浩
- Organizer
  第9回日本NO学会
- Place of Presentation
  グランシップ(静岡県静岡市)
- Year and Date
  2009-05-09
- Data Source
  KAKENHI-PROJECT-20015045
[Presentation] Remarkable augmentation of tumor delivery based on EPR-effect by topical applications of nitroglycerin2009
- Author(s)
  関孝弘、方軍、前田浩
- Organizer
  36th Annual Meeting & Exposition of the Controlled Release Society
- Place of Presentation
  Bella Center(デンマークコペンハーゲン)
- Year and Date
  2009-07-20
- Data Source
  KAKENHI-PROJECT-20015045
[Presentation] 成人T細胞白血病細胞に対するミセル化亜鉛プロトポルフィリンの増殖抑制作用(Growth inhibition of pegylated zinc protoporphyrin(PEG-ZnPP)on adult T-cell leukemia cells)2009
- Author(s)
  覃海波、方軍、中村秀明、前田浩
- Organizer
  第68回日本癌学会学術総会
- Place of Presentation
  パシフィコ横浜
- Year and Date
  2009-10-03
- Data Source
  KAKENHI-PROJECT-20015045
[Presentation] 成人T細胞白血病細胞に対するミセル化亜鉛プロトポルフィリンの増殖抑制作用2009
- Author(s)
  覃海波、方軍、中村秀明、前田浩
- Organizer
  第68回日本癌学会学術総会
- Place of Presentation
  横浜
- Year and Date
  2009-10-03
- Data Source
  KAKENHI-PROJECT-20015045
[Presentation] Remarkable augmentation of tumor delivery based on EPR-effect by topical applications of nitroglycerin2009
- Author(s)
  T. Seki, J. Fang, H. Maeda
- Organizer
  36th Annual Meeting & Exposition of the Controlled Release Society
- Place of Presentation
  コペンハーゲン
- Year and Date
  2009-07-20
- Data Source
  KAKENHI-PROJECT-20015045
[Presentation] SMA-copolymer conjugates of AHPP : a polymeric inhibitor of xanthine oxidase with therapeutic potentials against hypertension2009
- Author(s)
  方軍
- Organizer
  36th Annual Meeting & Exposition of the Controlled Release Society
- Place of Presentation
  デンマーク(コペンハーゲン)
- Year and Date
  2009-07-18
- Data Source
  KAKENHI-PROJECT-20590049
[Presentation] ニトログリセリン軟膏塗布による癌局所への高分子制癌剤のEPR効果増強に基づくデリバリーと治療効果の増強2009
- Author(s)
  関孝弘、方軍、前田浩
- Organizer
  第9回日本NO学会
- Place of Presentation
  静岡市
- Year and Date
  2009-05-09
- Data Source
  KAKENHI-PROJECT-20015045
[Presentation] キセノン光照射によるミセル化亜鉛プロトポルフィリンの抗癌作用の増強(Enhanced antitumor effect of pegylated zinc protoporphyrin by light irradiation)2009
- Author(s)
  方軍等
- Organizer
  第68回日本癌学会学術総会
- Place of Presentation
  パシフィコ横浜
- Year and Date
  2009-10-01
- Data Source
  KAKENHI-PROJECT-20015045
[Presentation] キセノン光照射によるミセル化亜鉛プロトポルフィリンの抗癌作用の増強2009
- Author(s)
  方軍, 等
- Organizer
  第68回日本癌学会学術総会
- Place of Presentation
  横浜
- Year and Date
  2009-10-01
- Data Source
  KAKENHI-PROJECT-20015045
[Presentation] Oxystress-induced antitumor therapeutics via targeted-inhibiting heme oxygenase-1(HSP32)in tumor2008
- Author(s)
  方軍他
- Organizer
  Ehrlich II 2nd World conference on Magic Bullets
- Place of Presentation
  Nuremberg, Germany
- Year and Date
  2008-11-28
- Data Source
  KAKENHI-PROJECT-20015045
[Presentation] ミセル化ヘムオキシゲナーゼ-1(熱ショック蛋白質32)阻害剤PZPの抗腫瘍効果と前臨床研究2008
- Author(s)
  方軍, 他
- Organizer
  第67回日本癌学会学術総会
- Place of Presentation
  名古屋
- Year and Date
  2008-10-29
- Data Source
  KAKENHI-PROJECT-20015045
[Presentation] ミセル化ヘムオキシゲナーゼ-1(熱ショック蛋白質32)阻害剤PZPの抗腫瘍効果と前臨床研究2008
- Author(s)
  方軍他
- Organizer
  第67回日本癌学会学術総会
- Place of Presentation
  名古屋国際会議場
- Year and Date
  2008-10-29
- Data Source
  KAKENHI-PROJECT-20015045
[Presentation] Oxystress-induced antitumor therapeutics via targeted-inhibiting heme oxygenase-1 (HSP32) in tumor2008
- Author(s)
  方軍, 他
- Organizer
  Ehrlich II 2nd World conference on Magic Bullets
- Place of Presentation
  Nuremberg, Germany
- Year and Date
  2008-10-03
- Data Source
  KAKENHI-PROJECT-20015045
[Presentation] PEG-conjugated D-amino acid oxidase induced antitumor therapeutics via tumor-targeted delivery of oxystress.2007
- Author(s)
  方軍
- Organizer
  第23回日本DDS学会
- Place of Presentation
  熊本(日本)
- Data Source
  KAKENHI-PROJECT-17016076
[Presentation] Antitumor strategy using hydrogen peroxide generated by tumor-targeted delivery of peg-conjugated D-amino acid oxidase.2007
- Author(s)
  方軍
- Organizer
  第66回日本癌学会学術総会
- Place of Presentation
  横浜(日本)
- Data Source
  KAKENHI-PROJECT-17016076
[Presentation] Oxystress induced antitumor therapeutics via tumor-targeted delivery of peg-conjugated D-amino acid oxidase.2007
- Author(s)
  方軍
- Organizer
  第34回CRS学会
- Place of Presentation
  カリフォルニア(US)
- Data Source
  KAKENHI-PROJECT-17016076
[Presentation] Upregulation of HO-1 in colorectal cancer with increased circulation CO levels, potentially affects chemosensitivity.
- Author(s)
  Jun Fang, Hongzhuan Yin, Long Liao, Hiroshi Maeda.
- Organizer
  73th Annual Meeting of the Japanese Cancer Association.
- Place of Presentation
  パシフィコ横浜（神奈川県横浜市）
- Year and Date
  2014-09-25 – 2014-09-27
- Data Source
  KAKENHI-PROJECT-25430162
[Presentation] Micelles of CO releasing molecules encapsulated by styrene-maleic acid copolymer, exhibit therapeutic potential for inflammatory bowel disease with disease-targeting property by EPR effect.
- Author(s)
  Jun Fang, Haibo Qin, Hongzhuan Yin, Hideaki Nakamura, Hiroshi Maeda.
- Organizer
  10th International Symposium on Polymer Therapeutics: From laboratory to Clinical Practice.
- Place of Presentation
  Valencia (Spain)
- Year and Date
  2014-05-19 – 2014-05-21
- Data Source
  KAKENHI-PROJECT-25430162

1. NAKAMURA Hideaki (30435151)

# of Collaborated Projects: 4 results

# of Collaborated Products: 35 results
2. MAEDA Hiroshi (90004613)

# of Collaborated Projects: 3 results

# of Collaborated Products: 45 results
3. Shintaro Yanazume (40623343)

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
4. 赤池孝章 (20231798)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
5. IMAMURA Takahisa

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
6. 小田切優樹

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
7. 原武衛

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

FAN Jun 方 軍

方 軍 ファン ジュン

Research Projects

Research Products

Co-Researchers

Investigation of the Anticancer Effects of Carbon Monoxide Nanopreparations Targeting Cancer Cell Metabolic ReprogrammingPrincipal Investigator

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Augmentation of EPR effect and therapeutic effect of nanomedicine by inhibiting off-targeting deliveryPrincipal Investigator

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Clinical application of photodynamic therapy using HPMA-ZnPP for gynecologic cancer

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Augmentation of EPR effect and therapeutic effect of nanomedicine by improving tumor microenvironmentPrincipal Investigator

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Design and evaluation of the theranostic potential of tumor-targeted polymeric micelle of zinc protoporphyrinPrincipal Investigator

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Development of zinc protoporphyrin micelles for cancer photodymanic therapy with xenon lightPrincipal Investigator

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Macromolecular anticancer agent, PEGylated Zinc protoporphyrin (ZnP) targeting HSP32

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New miceller agent for antioxidation therapy based on XO inhibition using AHPP

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EPR効果に基づく活性酸素生成型高分子薬の固形癌ターゲティング療法

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[Book] Nanotechnology in Health Care2012

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[Book] PEGylated zinc protoporphyrin: a micelle forming polymeric drug for cancer therapy.2012

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[Book] Liver tumor targeting In Drug Delivery in Oncology. From Basic Research to Cancer Therapy2011

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[Book] PEGylated Zinc Protoporphyrin : A Micelle Forming Polymeric Drug for Cancer Therapy in Nanotechnology in Health Care (Ed.Sanjeeb Sahoo)2011

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[Book] Pharm. Perspective of Cancers Therapeutics(eds. Y.Lu and R.I.Mahato, Tumor targeted macromolecular drug delivery based on the enhanced permeability and retention effect in solid tumor.)2009

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FAN Jun 方軍

方軍ファンジュン