Nagai Yuji 永井裕司

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NAGAI Yuji 永井裕司

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Researcher Number	20415409
Other IDs
Affiliation (Current)	2025: 国立研究開発法人量子科学技術研究開発機構, 量子医科学研究所脳機能イメージング研究センター, 主任研究員 2025: 国立研究開発法人量子科学技術研究開発機構, 量子医科学研究所脳機能イメージング研究部, 主任研究員
Affiliation (based on the past Project Information) *help	2024: 国立研究開発法人量子科学技術研究開発機構, 量子医科学研究所脳機能イメージング研究センター, 主任研究員 2023: 国立研究開発法人量子科学技術研究開発機構, 量子医科学研究所脳機能イメージング研究部, 主任研究員 2021: 国立研究開発法人量子科学技術研究開発機構, 量子医科学研究所脳機能イメージング研究部, 研究員 2019 – 2020: 国立研究開発法人量子科学技術研究開発機構, 放射線医学総合研究所脳機能イメージング研究部, 研究員(任常) 2016 – 2017: 量子科学技術研究開発機構, 放射線医学総合研究所・脳機能イメージング研究部, 研究員 … More 2010 – 2012: National Institute of Radiological Sciences, 分子イメージング研究センター, 研究員 2011: 独立行政法人放射線医学総合研究所, 研究員 2009: National Institute of Radiological Sciences, 分子イメージング研究センター, 技術員 Less
Review Section/Research Field	Principal Investigator Radiation science / Basic Section 42040:Laboratory animal science-related / Basic Section 52040:Radiological sciences-related Except Principal Investigator Basic / Social brain science / Neuroscience in general
Keywords	Principal Investigator ポジトロンCT / 化学遺伝学 / DREADD / PET / パーキンソン病 / 核医学(PETを含む) / PSAM / 霊長類モデル / 陽電子放出断層撮像法 / DCZ … More / in vivo imaging / 非ヒト霊長類 / ドーパミン受容体 / 遂行機能障害 / トランスルーショナルリサーチ / トランスレーショナルリサーチ / 高次脳機能障害 … More Except Principal Investigator サル / 脳・神経 / PET / ドーパミン / 霊長類 / コスト / DREADD / 意欲 / 脳神経疾患 / 神経科学 / 認知科学 / DREADDs / 遅延報酬割引 / 意思決定 / 遺伝子 / 化学遺伝学 / イメージング / 受容体 / モノアミン / 前頭前野 / 大脳皮質 / マーモセット / 分子イメージング / 認知神経科学 Less

化学遺伝学技術を利用した精神・神経疾患霊長類モデル動物作出技術の確立Principal Investigator
- Principal Investigator
  
  永井裕司
- Project Period (FY)
  2023 – 2026
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 42040:Laboratory animal science-related
- Research Institution
  National Institutes for Quantum Science and Technology
Optimization of DREADDs technology to the non-human primate brain using in vivo imagingPrincipal Investigator
- Principal Investigator
  
  Nagai Yuji
- Project Period (FY)
  2019 – 2021
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 52040:Radiological sciences-related
- Research Institution
  National Institutes for Quantum Science and Technology
In vivo neural projection mapping technology with a novel PET ligand
- Principal Investigator
  
  Minamimoto Takafumi
- Project Period (FY)
  2015 – 2016
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Basic / Social brain science
- Research Institution
  National Institutes for Quantum and Radiological Science and Technology
Neural mechanism of cost-benefit based controlling motivation
- Principal Investigator
  
  Minamimoto Takafumi
- Project Period (FY)
  2014 – 2017
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Basic / Social brain science
- Research Institution
  National Institutes for Quantum and Radiological Science and Technology
In vivo molecular neuroimaging for executive dysfunction in non-human primate model of Parkinson's diseasePrincipal Investigator
- Principal Investigator
  
  NAGAI Yuji
- Project Period (FY)
  2011 – 2012
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Radiation science
- Research Institution
  National Institute of Radiological Sciences
Distribution of dopamine receptors in the marmoset brain : a PET study
- Principal Investigator
  
  TSUJIMOTO Satoshi
- Project Period (FY)
  2010 – 2011
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Neuroscience in general
- Research Institution
  Kobe University
In vivo molecular neuroimaging for motor or cognitive dysfunction in non-human primate model of Parkinson's diseasePrincipal Investigator
- Principal Investigator
  
  NAGAI Yuji
- Project Period (FY)
  2009 – 2010
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Radiation science
- Research Institution
  National Institute of Radiological Sciences

All 2023 2022 2021 2020 2019 2017 2016 2015 2012 Other

All Journal Article Presentation Patent

[Journal Article] Targeted Delivery of Chemogenetic Adeno-Associated Viral Vectors to Cortical Sulcus Regions in Macaque Monkeys by Handheld Injections2023
- Author(s)
  Oyama Kei、Nagai Yuji、Minamimoto Takafumi
- Journal Title
  
  BIO-PROTOCOL
  
  Volume: 13 Issue: 23
- DOI
  10.21769/bioprotoc.4897
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-21K07268, KAKENHI-PLANNED-20H05955, KAKENHI-PUBLICLY-22H05521, KAKENHI-PROJECT-23K27098
[Journal Article] Multimodal imaging for validation and optimization of ion channel-based chemogenetics in nonhuman primates2023
- Author(s)
  Yuki Hori, Yuji Nagai, Yukiko Hori, Kei Oyama, Koki Mimura, Toshiyuki Hirabayashi, Ken-ichi Inoue, Masayuki Fujinaga, Ming-Rong Zhang, Masahiko Takada, Makoto Higuchi, Takafumi Minamimoto
- Journal Title
  
  Journal of Neuroscience
  
  Volume: 43 Issue: 39 Pages: 6619-6627
- DOI
  10.1523/jneurosci.0625-23.2023
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-23K11796, KAKENHI-PROJECT-21K07268, KAKENHI-PROJECT-22K19480, KAKENHI-PROJECT-19H01038, KAKENHI-PROJECT-19H05467, KAKENHI-PLANNED-20H05955, KAKENHI-PLANNED-22H05157, KAKENHI-PUBLICLY-22H05521, KAKENHI-PROJECT-23K27098, KAKENHI-PROJECT-23K27472
[Journal Article] Chronic Behavioral Manipulation via Orally Delivered Chemogenetic Actuator in Macaques2022
- Author(s)
  Oyama Kei、Hori Yukiko、Nagai Yuji、Miyakawa Naohisa、Mimura Koki、Hirabayashi Toshiyuki、Inoue Ken-ichi、Takada Masahiko、Higuchi Makoto、Minamimoto Takafumi
- Journal Title
  
  The Journal of Neuroscience
  
  Volume: 42 Issue: 12 Pages: 2552-2561
- DOI
  10.1523/jneurosci.1657-21.2021
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K07811, KAKENHI-PROJECT-19K08138, KAKENHI-PROJECT-18K15353, KAKENHI-PROJECT-19H01038, KAKENHI-PROJECT-19H05467, KAKENHI-PUBLICLY-20H04596, KAKENHI-PUBLICLY-20H05062, KAKENHI-PUBLICLY-21H05836, KAKENHI-PROJECT-18H04037, KAKENHI-PROJECT-19H03335
[Journal Article] Deschloroclozapine, a potent and selective chemogenetic actuator enables rapid neuronal and behavioral modulations in mice and monkeys2020
- Author(s)
  Nagai Yuji, Miyakawa Naohisa et al.
- Journal Title
  
  Nature Neuroscience
  
  Volume: 23 Issue: 9 Pages: 1157-1167
- DOI
  10.1038/s41593-020-0661-3
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K08138, KAKENHI-PROJECT-20K06929, KAKENHI-PROJECT-18K15353, KAKENHI-PUBLICLY-19H04996, KAKENHI-PROJECT-18H04037, KAKENHI-PROJECT-17H02219
[Journal Article] Deschloroclozapine: a potent and selective chemogenetic actuator enables rapid neuronal and behavioral modulations in mice and monkeys2019
- Author(s)
  Nagai Y, Miyakawa N, et al.
- Journal Title
  
  bioRxiv
  
  Volume: - Pages: 1157-1167
- DOI
  10.1101/854513
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K08138, KAKENHI-ORGANIZER-15H05871, KAKENHI-PUBLICLY-19H04996, KAKENHI-INTERNATIONAL-15K21731, KAKENHI-PROJECT-19H05467, KAKENHI-PUBLICLY-19H04984, KAKENHI-PUBLICLY-20H05062, KAKENHI-PROJECT-19H03335, KAKENHI-PROJECT-19K22470
[Journal Article] PET imaging-guided chemogenetic silencing reveals a critical role of primate rostromedial caudate in reward evaluation.2016
- Author(s)
  Nagai Y, Kikuchi E, Lerchner W, Inoue Ki, Ji B, Eldridge MA, Kaneko H, Kimura Y, Oh-Nishi A, Hori Y, Kato Y, Hirabayashi T, Fujimoto A, Kumata K, Zhang MR, Aoki I, SuharaT, Higuchi M, Takada M, Richmond BJ, Minamimoto T.
- Journal Title
  
  Nature Communications
  
  Volume: 7 Issue: 1 Pages: 13605-13605
- DOI
  10.1038/ncomms13605
- NAID
  120005898960
- Peer Reviewed / Acknowledgement Compliant / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PUBLICLY-15H01419, KAKENHI-PUBLICLY-15H01431, KAKENHI-PUBLICLY-15H01434, KAKENHI-PLANNED-15H05917, KAKENHI-PUBLICLY-16H01611, KAKENHI-PROJECT-16H02454, KAKENHI-PROJECT-15H06872, KAKENHI-PROJECT-26282221, KAKENHI-PROJECT-15K12772, KAKENHI-PROJECT-15K14316, KAKENHI-PROJECT-16KT0193
[Journal Article] Correlation between decreased motor activity and dopaminergic degeneration in the ventrolateral putamen in monkeys receiving repeated MPTP administrations: A positron emission tomography study2012
- Author(s)
  Yuji Nagai, Takafumi Minamimoto, Kiyoshi Ando, Shigeru Obayashi, Hiroshi Ito, Nobuhiko Ito, Tetsuya Suhara
- Journal Title
  
  Neuroscience research
  
  Volume: 73巻 Issue: 1 Pages: 61-67
- DOI
  10.1016/j.neures.2012.02.007
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23791469
[Patent] 人工受容体に結合する新規化合物、人工受容体のイメージング方法、アゴニストまたはアンタゴニスト、治療薬、コンパニオン診断薬、神経細胞のイメージング方法2019
- Inventor(s)
  南本敬史, 永井裕司, 季斌, 宮川尚久, 樋口真人, 須原哲也
- Industrial Property Rights Holder
  国立研究開発法人量子科学技術研究開発機構
- Industrial Property Rights Type
  特許
- Filing Date
  2019
- Acquisition Date
  2021
- Data Source
  KAKENHI-PROJECT-19K08138
[Presentation] Longitudinal assessment of DREADD expression and efficacy in the monkey brain2022
- Author(s)
  Yuji Nagai, Yukiko Hori, Ken-ichi Inoue, Kei Oyama, Naohisa Miyakawa, Toshiyuki Hirabayashi, Koki Mimura, Tetsuya Suhara, Masahiko Takada, Makoto Higuchi, Takafumi Minamimoto
- Organizer
  第45回日本神経科学大会
- Data Source
  KAKENHI-PROJECT-19K08138
[Presentation] 化学遺伝学受容体の新規リガンドdeschloroclozapineは迅速で選択的な神経細胞活動および行動を操作を可能する2021
- Author(s)
  永井裕司
- Organizer
  第94回日本薬理学会年会
- Data Source
  KAKENHI-PROJECT-19K08138
[Presentation] 化学遺伝学とPETイメージングによるサル脳活動操作とモニタリング2020
- Author(s)
  永井裕司, 宮川尚久, Xi-Ping Haung, Samuel T. Slocum, Yan Xiong, 堀由紀子, 小山佳, 季斌, 平林敏行, 藤本淳, 三村喬生, Justin G. English, Jing Liu, 井上謙一, 熊田勝志, 関千江, 張明栄, 須原哲也, 高田昌彦, 樋口真人, Jian Jin, Bryan L. Roth, 南本敬史
- Organizer
  第66回日本獣医画像診断学会
- Data Source
  KAKENHI-PROJECT-19K08138
[Presentation] A novel ligand selectively visualizes and activates chemogenetic receptors in non-human primates2020
- Author(s)
  Yuji Nagai
- Organizer
  The 93rd Annual Meeting of the Japanese Pharmacological Society
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K08138
[Presentation] A novel ligand “deschloroclozapine” selectively visualizes and activates chemogenetic receptors in non-human primates2019
- Author(s)
  Nagai Y, Miyakawa N, et al.
- Organizer
  BrainPET 2019
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K08138
[Presentation] 8.Predicted reward value in the rostromedial caudate and the ventral pallidum for goal-directed action in monkeys.2017
- Author(s)
  Fujimoto A, Hori Y, Nagai Y, McCairn KW, Hirabayashi T, Kikuchi E, Takada M, Suhara T, Minamimoto T
- Organizer
  第４０回日本神経科学大会
- Data Source
  KAKENHI-PROJECT-26282221
[Presentation] 3.Encoding expected reward value for formulating goal-directed decision in the rostro-medial caudate and the ventral pallidum.2017
- Author(s)
  Fujimoto A, Hori Y, Nagai Y, McCairn KW, Hirabayashi T, Kikuchi E, Takada M, Suhara T, Minamimoto T
- Organizer
  Society for Neuroscience
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26282221
[Presentation] 1.Region-specific effects of bilateral inactivation of limbic striatum on reward-related behavior in monkeys.2015
- Author(s)
  Kikuchi E, Hori Y, Nagai Y, Suhara T, Samejima K, Minamimoto T.
- Organizer
  日本神経科学学会
- Place of Presentation
  神戸国際会議場
- Year and Date
  2015-08-28
- Data Source
  KAKENHI-PROJECT-26282221
[Presentation] In vivo PET imaging of the behaviorally active designer receptor in macaques
- Author(s)
  1)Nagai Y, Kikuchi E, Lerchner W, Inoue K, Oh-Nishi A, Kaneko H, Kato Y, Hori Y, Ji B, Kumata K, Zhang MR, Aoki I, Suhara T, Takada M, Higuchi M, Richmond BJ, Minamimoto T.
- Organizer
  Neuro2014
- Place of Presentation
  横浜
- Year and Date
  2014-09-11 – 2014-09-13
- Data Source
  KAKENHI-PROJECT-26282221
[Presentation] In vivo PET imaging of the behaviorally active designer receptor in macaque monkeys.
- Author(s)
  4)Nagai Y, Kikuchi E, Lerchner W, Inoue K, Oh-Nishi A, Kaneko H, Kato Y, Hori Y, Ji B, Kumata K, Zhang MR, Aoki I, Suhara T, Takada M, Higuchi M, Richmond BJ, Minamimoto T.
- Organizer
  Society for Neuroscience
- Place of Presentation
  Washington DC
- Year and Date
  2014-11-15 – 2014-11-19
- Data Source
  KAKENHI-PROJECT-26282221

1. Minamimoto Takafumi (50506813)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
2. KIKUCHI Erika

# of Collaborated Projects: 2 results

# of Collaborated Products: 5 results
3. TSUJIMOTO Satoshi (20539241)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
4. MINAMIMOTO Takafumi (23011006)

# of Collaborated Projects: 1 results

# of Collaborated Products: 5 results
5. JI Bin (80392223)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
6. HORI Yukiko (30433246)

# of Collaborated Projects: 1 results

# of Collaborated Products: 5 results
7. HIRABAYASHI Toshiyuki

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
8. MIYAKAWA Naohisa

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
9. 小山佳

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
10. 堀祐樹

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Nagai Yuji 永井 裕司

NAGAI Yuji 永井 裕司

Research Projects

Research Products

Co-Researchers

化学遺伝学技術を利用した精神・神経疾患霊長類モデル動物作出技術の確立Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Optimization of DREADDs technology to the non-human primate brain using in vivo imagingPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

In vivo neural projection mapping technology with a novel PET ligand

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Neural mechanism of cost-benefit based controlling motivation

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

In vivo molecular neuroimaging for executive dysfunction in non-human primate model of Parkinson's diseasePrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Distribution of dopamine receptors in the marmoset brain : a PET study

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

In vivo molecular neuroimaging for motor or cognitive dysfunction in non-human primate model of Parkinson's diseasePrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] Targeted Delivery of Chemogenetic Adeno-Associated Viral Vectors to Cortical Sulcus Regions in Macaque Monkeys by Handheld Injections2023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Multimodal imaging for validation and optimization of ion channel-based chemogenetics in nonhuman primates2023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Chronic Behavioral Manipulation via Orally Delivered Chemogenetic Actuator in Macaques2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Deschloroclozapine, a potent and selective chemogenetic actuator enables rapid neuronal and behavioral modulations in mice and monkeys2020

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Deschloroclozapine: a potent and selective chemogenetic actuator enables rapid neuronal and behavioral modulations in mice and monkeys2019

Author(s)

Journal Title

DOI

Data Source

[Journal Article] PET imaging-guided chemogenetic silencing reveals a critical role of primate rostromedial caudate in reward evaluation.2016

Author(s)

Journal Title

DOI

NAID

Data Source

[Journal Article] Correlation between decreased motor activity and dopaminergic degeneration in the ventrolateral putamen in monkeys receiving repeated MPTP administrations: A positron emission tomography study2012

Author(s)

Nagai Yuji 永井裕司

NAGAI Yuji 永井裕司