Yokota Akiko 横田亜紀子

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YOKOTA Akiko 横田亜紀子

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Researcher Number	20415764
Other IDs
Affiliation (Current)	2025: 国立研究開発法人産業技術総合研究所, 生命工学領域, 主任研究員
Affiliation (based on the past Project Information) *help	2019 – 2023: 国立研究開発法人産業技術総合研究所, 生命工学領域, 主任研究員 2017: 国立研究開発法人産業技術総合研究所, 生命工学領域, 主任研究員 2015 – 2016: 国立研究開発法人産業技術総合研究所, バイオメディカル研究部門, 主任研究員 2010 – 2011: 独立行政法人産業技術総合研究所, バイオメディカル研究部門, 研究員
Review Section/Research Field	Principal Investigator Basic Section 43030:Functional biochemistry-related / Biofunction/Bioprocess / Biofunction/Bioprocess Except Principal Investigator Basic Section 38020:Applied microbiology-related
Keywords	Principal Investigator タンパク質-核酸相互作用 / 酵素 / スクリーニングシステム / ドロップレット / 蛍光検出 / 高速スクリーニング / w/oエマルション / 変異ライブラリ / 分子認識 / 核酸 … More / 抗生物質 / バイオテクノロジー / 特異的認識配列 / 蛋白質-核酸相互作用 / RNAシーケンス / 配列特異的認識機構 / Toxin-Antitoxinシステム / 変異解析 / 機能改変 / 蛋白質 … More Except Principal Investigator 小分子化合物 / Nuclease / TAシステム / MazEF / 抗菌活性 / トキシンタンパク質 Less

Library construction and establishment of high-throughput screening system for the discovery of novel useful proteinsPrincipal Investigator
- Principal Investigator
  
  Yokota Akiko
- Project Period (FY)
  2019 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 43030:Functional biochemistry-related
- Research Institution
  National Institute of Advanced Industrial Science and Technology
Screening for compounds that disrupt the toxin-antitoxin complex and evaluation of their function
- Principal Investigator
  
  Noda Naohiro
- Project Period (FY)
  2019 – 2021
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 38020:Applied microbiology-related
- Research Institution
  National Institute of Advanced Industrial Science and Technology
Investigation on molecular basis of toxin-antitoxin systems and its application for genetic engineering and control of cellular responsesPrincipal Investigator
- Principal Investigator
  
  Yokota Akiko
- Project Period (FY)
  2015 – 2017
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Biofunction/Bioprocess
- Research Institution
  National Institute of Advanced Industrial Science and Technology
Development of a new strategy for protein design based on a systematic mutant databasePrincipal Investigator
- Principal Investigator
  
  YOKOTA Akiko
- Project Period (FY)
  2010 – 2011
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Biofunction/Bioprocess
- Research Institution
  National Institute of Advanced Industrial Science and Technology

All 2024 2023 2022 2021 2018 2017 2016 2015 2012

All Journal Article Presentation Patent

[Journal Article] Arg-73 of the RNA endonuclease MazF in Salmonella enterica subsp. arizonae contributes to guanine and uracil recognition in the cleavage sequence2024
- Author(s)
  Okabe Takuma、Aoi Rie、Yokota Akiko、Tamiya-Ishitsuka Hiroko、Jiang Yunong、Sasaki Akira、Tsuneda Satoshi、Noda Naohiro
- Journal Title
  
  Journal of Biological Chemistry
  
  Volume: 300 Issue: 2 Pages: 105636-105636
- DOI
  10.1016/j.jbc.2024.105636
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K06555
[Journal Article] MazEF Homologs in Symbiobacterium thermophilum Exhibit Cross-Neutralization with Non-Cognate MazEFs2024
- Author(s)
  Jiang Yu-Nong、Tamiya-Ishitsuka Hiroko、Aoi Rie、Okabe Takuma、Yokota Akiko、Noda Naohiro
- Journal Title
  
  Toxins
  
  Volume: 16 Issue: 2 Pages: 81-81
- DOI
  10.3390/toxins16020081
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K06555
[Journal Article] Conserved Amino Acid Moieties of Candidatus Desulforudis audaxviator MazF Determine Ribonuclease Activity and Specificity2021
- Author(s)
  Tamiya-Ishitsuka Hiroko、Tsuruga Masako、Noda Naohiro、Yokota Akiko
- Journal Title
  
  Frontiers in Microbiology
  
  Volume: 12
- DOI
  10.3389/fmicb.2021.748619
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19H02879, KAKENHI-PROJECT-19K06555
[Journal Article] Characterization of a Deinococcus radiodurans MazF: A UACA-specific RNA endoribonuclease2017
- Author(s)
  Miyamoto Tatsuki、Ota Yuri、Yokota Akiko、Suyama Tetsushi、Tsuneda Satoshi、Noda Naohiro
- Journal Title
  
  MicrobiologyOpen
  
  Volume: 6 Issue: 5
- DOI
  10.1002/mbo3.501
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-16J09473, KAKENHI-PROJECT-15K14241
[Journal Article] AAU-Specific RNA Cleavage Mediated by MazF Toxin Endoribonuclease Conserved in Nitrosomonas europaea2016
- Author(s)
  Tatsuki Miyamoto, Akiko Yokota, Satoshi Tsuneda, Naohiro Noda
- Journal Title
  
  Toxins (Basel)
  
  Volume: 8 Issue: 6 Pages: 174-174
- DOI
  10.3390/toxins8060174
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-16J09473, KAKENHI-PROJECT-15K14241
[Patent] エンドリボヌクレアーゼ、およびその阻害物質2018
- Inventor(s)
  宮本龍樹，横田亜紀子，大田悠里，野田尚宏，常田聡
- Industrial Property Rights Holder
  国立研究開発法人産業技術総合研究所
- Industrial Property Rights Type
  特許
- Industrial Property Number
  2018-061354
- Filing Date
  2018
- Data Source
  KAKENHI-PROJECT-15K14241
[Presentation] The specific amino acid of the MazF RNA endonuclease in Salmonella enterica is directly responsible for the RNA cleavage sequence2023
- Author(s)
  岡部拓真、葵理恵、横田亜紀子、石塚寛子、江雨濃、佐々木章、常田聡、野田尚宏
- Organizer
  Microbe & RNA 2023
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K06555
[Presentation] Unraveling Stress Response Mechanisms via Salmonella enterica MazF Cleavage Sequences2023
- Author(s)
  岡部拓真、葵理恵、横田亜紀子、石塚寛子、江雨濃、常田聡、野田尚宏
- Organizer
  第36回日本微生物生態学会＆第13回ASME
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K06555
[Presentation] 配列特異的エンドリボヌクレアーゼMazFのライブラリ構築とその応用可能性2022
- Author(s)
  横田亜紀子、宮本龍樹、大田悠里、釣賀雅子、葵理恵、石塚寛子、岡部拓真、江雨濃、常田聡、野田尚宏
- Organizer
  産総研・産技連LS-BT合同研究発表会
- Data Source
  KAKENHI-PROJECT-19K06555
[Presentation] 極限環境微生物Candidatus Desulforudis audaxviator MazFの高度に保存されたアミノ酸の役割2022
- Author(s)
  石塚寛子、釣賀雅子、野田尚宏、横田亜紀子
- Organizer
  第74回日本生物工学会大会
- Data Source
  KAKENHI-PROJECT-19K06555
[Presentation] 極限環境微生物由来トキシンタンパクMazFの高温下における機能および安定性の評価2022
- Author(s)
  石塚寛子、江雨濃、岡部拓真、横田亜紀子、野田尚宏
- Organizer
  第45回日本分子生物学会年会
- Data Source
  KAKENHI-PROJECT-19K06555
[Presentation] Function analysis of type II toxin-antitoxin MazEF in symbiotic thermophile S2022
- Author(s)
  江雨濃、石塚寛子、葵理恵、岡部拓真、横田亜紀子、野田尚宏
- Organizer
  The 14th Japan-China-Korea International Postgraduate Academic Forum
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K06555
[Presentation] Clostridium perfringens由来Toxin-AntitoxinシステムMazEFについて：分子認識機構と生理機能の考察2021
- Author(s)
  横田亜紀子（登壇者）、宮本龍樹、大田悠里、釣賀雅子、常田聡、野田尚宏
- Organizer
  日本農芸化学会2021年度大会
- Data Source
  KAKENHI-PROJECT-19K06555
[Presentation] Bacillus pumilusが保有するMazF分子の機能解析2021
- Author(s)
  岡部拓真、葵理恵、石塚寛子、江雨濃、横田亜紀子、常田聡、野田尚宏
- Organizer
  第15回細菌学若手コロッセウム
- Data Source
  KAKENHI-PROJECT-19H02879
[Presentation] Clostridium perfringens由来Toxin-AntitoxinシステムMazEFについて：分子認識機構と生理機能の考察2021
- Author(s)
  横田亜紀子
- Organizer
  日本農芸化学会2021年度大会
- Data Source
  KAKENHI-PROJECT-19H02879
[Presentation] Toxin-Antitoxin機構の分子認識機構: RNA干渉酵素の認識切断配列の同定手法の確立2018
- Author(s)
  野田尚宏、宮本　龍樹、関口勇地、横田亜紀子、大田悠里、常田　聡
- Organizer
  第91回日本細菌学会総会
- Data Source
  KAKENHI-PROJECT-15K14241
[Presentation] 硝化細菌におけるストレス応答機構の解明: Toxin-antitoxin機構はなぜ必要なのか？2017
- Author(s)
  宮本　龍樹、横田亜紀子、大田悠里、常田聡、野田尚宏
- Organizer
  第二回環境微生物系学会合同大会2017
- Data Source
  KAKENHI-PROJECT-15K14241
[Presentation] SCREENING DISRUPTORS OF THE TOXIN-ANTITOXIN COMPLEX IN STAPHYLOCOCCUS AUREUS2017
- Author(s)
  大田悠里、宮本龍樹、横田亜紀子、常田聡、野田尚宏
- Organizer
  The 7th Congress of European Microbiologists (FEMS 2017)
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K14241
[Presentation] CHARACTERIZATION OF A SEQUENCE-SPECIFIC CUTTER CONSERVED IN THE NITROSOMONAS EUROPAEA CHROMOSOME2017
- Author(s)
  宮本　龍樹、横田亜紀子、大田悠里、常田聡、野田尚宏
- Organizer
  The 7th Congress of European Microbiologists (FEMS 2017)
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K14241
[Presentation] Characterization of a chromosomal toxin-antitoxin module conserved in Nitrosomonas europaea2017
- Author(s)
  宮本　龍樹、横田亜紀子、大田悠里、常田聡、野田尚宏
- Organizer
  How Dead is Dead Conference V
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K14241
[Presentation] 病原性微生物を対象としたプログラム細胞死誘導物質の探索2016
- Author(s)
  大田悠里、宮本龍樹、横田亜紀子、常田聡、野田尚宏
- Organizer
  第68回　日本生物工学会大会
- Place of Presentation
  富山国際会議場、ANAクラウンプラザホテル富山（富山県富山市）
- Data Source
  KAKENHI-PROJECT-15K14241
[Presentation] Toxin-antitoxin分子認識機構：病原菌由来RNAインターフェレンスの特異的認識配列の同定2016
- Author(s)
  横田亜紀子、宮本龍樹、大田悠里、常田聡、野田尚宏
- Organizer
  第68回　日本生物工学会大会
- Place of Presentation
  富山国際会議場、ANAクラウンプラザホテル富山（富山県富山市）
- Data Source
  KAKENHI-PROJECT-15K14241
[Presentation] 病原性微生物に対する新規抗菌分子の探索2016
- Author(s)
  大田悠里、宮本龍樹、横田亜紀子、常田聡、野田尚宏
- Organizer
  第10回細菌学若手コロッセウム
- Place of Presentation
  草津セミナーハウス（群馬県吾妻郡）
- Data Source
  KAKENHI-PROJECT-15K14241
[Presentation] ファージディスプレイ法によるプログラム細胞死誘導物質の探索2015
- Author(s)
  大田悠里、宮本龍樹、横田亜紀子、佐々木章、常田聡、野田尚宏
- Organizer
  第30回日本微生物生態学会大会
- Place of Presentation
  土浦亀城プラザ（茨城県土浦市）
- Year and Date
  2015-10-18
- Data Source
  KAKENHI-PROJECT-15K14241
[Presentation] 配列摂動解析によるジヒドロ葉酸還元酵素における保存部位の役割の解明2012
- Author(s)
  横田亜紀子
- Organizer
  日本化学会第92春季年会
- Place of Presentation
  慶應義塾大学日吉キャンパス、矢上キャンパス(神奈川県)
- Year and Date
  2012-03-25
- Data Source
  KAKENHI-PROJECT-22760616
[Presentation] 配列摂動解析:ジヒドロ葉酸還元酵素の保存部位に関する考察2012
- Author(s)
  横田亜紀子
- Organizer
  第11回産総研・産技連LS-BT合同研究発表会
- Place of Presentation
  産業技術総合研究所(茨城県)
- Year and Date
  2012-01-31
- Data Source
  KAKENHI-PROJECT-22760616

1. NODA Naohiro (70415727)

# of Collaborated Projects: 3 results

# of Collaborated Products: 20 results
2. 常田聡 (30281645)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results

Yokota Akiko 横田 亜紀子

YOKOTA Akiko 横田 亜紀子

Research Projects

Research Products

Co-Researchers

Library construction and establishment of high-throughput screening system for the discovery of novel useful proteinsPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Screening for compounds that disrupt the toxin-antitoxin complex and evaluation of their function

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Investigation on molecular basis of toxin-antitoxin systems and its application for genetic engineering and control of cellular responsesPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Development of a new strategy for protein design based on a systematic mutant databasePrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] Arg-73 of the RNA endonuclease MazF in Salmonella enterica subsp. arizonae contributes to guanine and uracil recognition in the cleavage sequence2024

Author(s)

Journal Title

DOI

Data Source

[Journal Article] MazEF Homologs in Symbiobacterium thermophilum Exhibit Cross-Neutralization with Non-Cognate MazEFs2024

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Conserved Amino Acid Moieties of Candidatus Desulforudis audaxviator MazF Determine Ribonuclease Activity and Specificity2021

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Characterization of a Deinococcus radiodurans MazF: A UACA-specific RNA endoribonuclease2017

Author(s)

Journal Title

DOI

Data Source

[Journal Article] AAU-Specific RNA Cleavage Mediated by MazF Toxin Endoribonuclease Conserved in Nitrosomonas europaea2016

Author(s)

Journal Title

DOI

Data Source

[Patent] エンドリボヌクレアーゼ、およびその阻害物質2018

Inventor(s)

Industrial Property Rights Holder

Industrial Property Rights Type

Industrial Property Number

Filing Date

Data Source

[Presentation] The specific amino acid of the MazF RNA endonuclease in Salmonella enterica is directly responsible for the RNA cleavage sequence2023

Author(s)

Organizer

Data Source

[Presentation] Unraveling Stress Response Mechanisms via Salmonella enterica MazF Cleavage Sequences2023

Author(s)

Organizer

Data Source

[Presentation] 配列特異的エンドリボヌクレアーゼMazFのライブラリ構築とその応用可能性2022

Author(s)

Organizer

Data Source

[Presentation] 極限環境微生物Candidatus Desulforudis audaxviator MazFの高度に保存されたアミノ酸の役割2022

Author(s)

Organizer

Data Source

[Presentation] 極限環境微生物由来トキシンタンパクMazFの高温下における機能および安定性の評価2022

Author(s)

Organizer

Yokota Akiko 横田亜紀子

YOKOTA Akiko 横田亜紀子