MIZOGUCHI Kazushige 溝口和臣

Researcher Number	20416176
Affiliation (based on the past Project Information) *help	2010: 独立行政法人国立長寿医療研究センター, その他 2009: National Institute for Longevity Sciences,NCGG, 老年病研究部・東洋医学研究室, 室長 2008: National Institute for Longevity Sciences,NCGG, 老年病研究部, 室長 2007 – 2008: National Institute for Longevity Sciences,NCGG, 老年病研究部・東洋医学研究室, 室長 2006: 国立長寿医療センター, (研究所)・老年病研究部・東洋医学研究室, 室長
Review Section/Research Field	Principal Investigator General internal medicine (including Psychosomatic medicine)
Keywords	Principal Investigator ラット / セロトニン / ドーパミン / 前頭前野 / ストレス / 老化 / 扁桃体 / ストレス脆弱性 / 視床下部-下垂体-副腎皮質系 / グルココルチコイド … More / 視床下部-下垂体-副腎軸 / 脳 / グルココルチコイド受容体 / うつ病 Less

老化による前頭前野の機能低下とストレス脆弱性の発生機構Principal Investigator
- Principal Investigator
  
  溝口和臣
- Project Period (FY)
  2009 – 2011
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  General internal medicine (including Psychosomatic medicine)
- Research Institution
  National Center for Geriatrics and Gerontology
Common factor(s) involving vulnerability to stress and pathophysiology of depression in the elderlyPrincipal Investigator
- Principal Investigator
  
  MIZOGUCHI Kazushige
- Project Period (FY)
  2006 – 2008
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  General internal medicine (including Psychosomatic medicine)
- Research Institution
  National Institute for Longevity Sciences,NCGG

All 2010 2009 2008 2007 Other

All Journal Article Presentation

[Journal Article] Acute and repeated stress differentially regulates behavioral, endocrine, neural parameters relevant to emotional and stress response in young and aged rats.2010
- Author(s)
  Shoji H, Mizoguchi K
- Journal Title
  
  Behav.Brain Res. 211
  
  Pages: 169-177
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21590781
[Journal Article] Anxiolytic effect of a herbal medicine, yokukansan, in aged rats : involvement of serotonergic and dopaminergic transmissions in the prefrontal cortex.2010
- Author(s)
  Mizoguchi K, Tanaka Y, Tabira T.
- Journal Title
  
  J.Ethnopharmacol. 127
  
  Pages: 70-76
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21590781
[Journal Article] ストレスと認知症2010
- Author(s)
  溝口和臣
- Journal Title
  
  認知症診療マニュアル 72(suppl.6)
  
  Pages: 57-61
- Data Source
  KAKENHI-PROJECT-21590781
[Journal Article] Age-related spatial working memory impairment is caused by prefrontal cortical dopaminergic dysfunction in rats.2009
- Author(s)
  Mizoguchi K, Shoji H, Tanaka Y, Maruyama W, Tabira T
- Journal Title
  
  Neuroscience 162
  
  Pages: 1192-1201
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21590781
[Journal Article] Saikokaryukotsuboreito, a herbal medicine, prevents chronic stress-induced anxiety in rats: comparison with diazepam2009
- Author(s)
  Mizoguchi K, Ikeda R, Shoji H, Tanaka Y Jin XL, Kase Y, Takeda S, Maruyama W, Tabira T
- Journal Title
  
  Nat. Med. (Tokyo) 63
  
  Pages: 69-74
- NAID
  10025825655
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18590663
[Journal Article] ストレスと柴胡加竜骨牡蛎湯2009
- Author(s)
  溝口和臣
- Journal Title
  
  薬局 60
  
  Pages: 130-134
- Data Source
  KAKENHI-PROJECT-21590781
[Journal Article] Influence of aging on chondroitin sulfate proteoglycan expression and neural stem/progenitor cells in rat brain and improving effects of a herbal medicine, yokukansan.2009
- Author(s)
  Tanaka Y, Mizoguchi K.
- Journal Title
  
  Neuroscience 164
  
  Pages: 1224-1234
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21590781
[Journal Article] Saikokaryukotsuboreito, a herbal medicine, prevents chronic stress-induced anxiety in rats : comparison with diazepam2009
- Author(s)
  Mizoguchi K., et al.
- Journal Title
  
  Nat. Med. (Tokyo) 63
  
  Pages: 69-74
- NAID
  10025825655
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18590663
[Journal Article] Persistent depressive state after chronic stress in rats is accompanied by HPA axis dysregulation and reduced prefrontal dopaminergic neurotransmission2008
- Author(s)
  Mizoguchi K., et al.
- Journal Title
  
  Pharmacol. Biochem. Behav. 91
  
  Pages: 170-175
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18590663
[Journal Article] Suppression of glucocorticoid secretion enhances cholinergic transmission in rat hippocampus2008
- Author(s)
  Mizoguchi K, Shoji H, Ikeda R, Tanaka Y, Maruyama W, Tabira T
- Journal Title
  
  Brain Res. Bull. 76
  
  Pages: 612-615
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18590663
[Journal Article] Suppression of glucocorticoid secretion induces a behaviorally depressive state in rotarod performance in rat2008
- Author(s)
  Mizoguchi K, Ikeda R, Shoji H, Tanaka Y, Tabira T
- Journal Title
  
  Pharmacol Biochem. Behav. 90
  
  Pages: 730-734
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18590663
[Journal Article] Suppression of glucocorticoid secretion enhances cholinergic transmission in rat hippocampus2008
- Author(s)
  Mizoguchi K., et al.
- Journal Title
  
  Brain Res. Bull. 76
  
  Pages: 612-615
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18590663
[Journal Article] Suppression of glucocorticoid secretion induces a behaviorally depressive state in rotarod performance in rat2008
- Author(s)
  Mizoguchi K., et al.
- Journal Title
  
  Pharmacol. Biochem. Behav. 90
  
  Pages: 730-734
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18590663
[Journal Article] Aging attenuates glucocorticoid negative feedback in rat brain2008
- Author(s)
  Mizoguchi K., et al.
- Journal Title
  
  Neuroscience 159
  
  Pages: 270-259
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18590663
[Journal Article] Persistent depressive state after chronic stress in rats is accompanied by HPA axis dysregulation and reduced prefrontal dopamhergic neurotransmission2008
- Author(s)
  Mizoguchi K, Shoji H, Ikeda R, Tanaka Y, Tabira T
- Journal Title
  
  Pharmacol. Biochem. Behav. 91
  
  Pages: 170-175
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18590663
[Journal Article] Saikokaryukotsuboreito, a herbal medicine, prevents chronic stress-induced dysfunction of glucocorticoid negative feedback system in rat brain2007
- Author(s)
  Mizoguchi K, Sun N, Jin XL, Kase Y, Takeda S, Maruyama W, Tabira T
- Journal Title
  
  Pharmacol. Biochem. Behav. 86
  
  Pages: 55-61
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18590663
[Journal Article] Saikokaryukotsuboreito, a herbal medicine, prevents chronic stress-induced dysfunction of glucocorticoid negative feedback system in rat brain.2007
- Author(s)
  Mizoguchi K., et. al.
- Journal Title
  
  Pharmacol. Biochem. Behav. 86
  
  Pages: 55-61
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18590663
[Journal Article] Effect of intracranial hypertension on cerebral hemorrhage induced autonomic nerve imbalance2007
- Author(s)
  Jin XL, Jing W, Yan F, Zhang Z, Lu F, Jing S, Sun N, Mizoguchi K
- Journal Title
  
  Neural Regen. Res. 2
  
  Pages: 175-178
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18590663
[Journal Article] Saikokaryukotsuboreito, a herbal medicine, prevents chronic stress-induced dysfunction of glucocorticoid negative feedback system in rat brain.2007
- Author(s)
  Mizoguchi K, Sun N, Jin XL, Kase Y, Takeda S, Maruyama W, Tabira T
- Journal Title
  
  Pharmacol.Biochem.Behav. 86・1
  
  Pages: 55-61
- Data Source
  KAKENHI-PROJECT-18590663
[Journal Article] Suppression of glucocorticoid secretion enhances cholinergic transmission in rat hippocampus.
- Author(s)
  Mizoguchi K., et. al.
- Journal Title
  
  Brain Res. Bull. (in press)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18590663
[Journal Article] Systemic disorders of calcium dynamics in rats with adenine-induced renal failure : implication for chronic kidney disease-related complications
- Author(s)
  Ikeda R, Imai Y, Maruyama W, Mizoguchi K.
- Journal Title
  
  Nephrology (印刷中)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18590663
[Journal Article] Systemic disorders of calcium dynamics in rats with adenine-induced renal failure : implication for chronic kidney disease-related complications
- Author(s)
  Ikeda R, Imai Y, Maruyama W, Mizoguchi K
- Journal Title
  
  Nephrology (in press)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18590663
[Journal Article] Age-related spatial working memory impairment is caused by prefrontal cortical dopaminergic dysfunction in rats
- Author(s)
  Mizoguchi K, Ikeda R, Shoii H, Tanaka Y, Maruyama W, Tabira T
- Journal Title
  
  Neuroscience (in press)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18590663
[Journal Article] Hachimijiogan (Ba-Wei-Di-Huang-Wan), a herbal medicine, improves unbalance of calcium metabolism in aged rats
- Author(s)
  Ikeda R, Mizoguchi K.
- Journal Title
  
  J. Ethnopharmacol (印刷中)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18590663
[Journal Article] Hachimijiogan (Ba- Wei-Di-Huang- Wan), a herbal medicine, improves unbalance of calcium metabolism in aged rats
- Author(s)
  Ikeda R, Mizoguchi K
- Journal Title
  
  J. Ethnopharmacol. (in press)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18590663
[Journal Article] Aging attenuates glucocorticoid negative feedback in rat brain
- Author(s)
  Mizoguchi K, Ikeda R, Shoji H, Tanaka Y, Maruyama W, Tabira T
- Journal Title
  
  Neuroscience 159
  
  Pages: 259-270
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18590663
[Presentation] 情動行動と内分泌反応を指標とした老齢ラットのストレス脆弱性とその脳内機構の検討2009
- Author(s)
  昌子浩孝、溝口和臣
- Organizer
  第69回日本動物心理学会大会
- Place of Presentation
  岐阜大学(岐阜県)
- Year and Date
  2009-09-26
- Data Source
  KAKENHI-PROJECT-21590781
[Presentation] 加齢による前頭前野の機能低下と漢方薬による改善作用(基礎)2008
- Author(s)
  溝口和臣, 池田龍史, 昌子浩孝, 田中弥生, 丸山和佳子, 田平武
- Organizer
  第8回抗加齢医学会総会(シンポジウム)
- Place of Presentation
  東京
- Year and Date
  2008-06-07
- Data Source
  KAKENHI-PROJECT-18590663
[Presentation] 柴胡加竜骨牡蛎湯の抗うつ作用2007
- Author(s)
  溝口和臣
- Organizer
  第25回泌尿器科漢方研究会
- Place of Presentation
  神戸
- Year and Date
  2007-04-14
- Data Source
  KAKENHI-PROJECT-18590663

1. SUN Nan (60419900)

# of Collaborated Projects: 2 results

# of Collaborated Products: 3 results
2. IKEDA Ryuji (80463199)

# of Collaborated Projects: 1 results

# of Collaborated Products: 11 results
3. SHOJI Hirotaka (00466278)

# of Collaborated Projects: 1 results

# of Collaborated Products: 6 results

MIZOGUCHI Kazushige 溝口 和臣

Research Projects

Research Products

Co-Researchers

老化による前頭前野の機能低下とストレス脆弱性の発生機構Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Common factor(s) involving vulnerability to stress and pathophysiology of depression in the elderlyPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] Acute and repeated stress differentially regulates behavioral, endocrine, neural parameters relevant to emotional and stress response in young and aged rats.2010

Author(s)

Journal Title

Data Source

[Journal Article] Anxiolytic effect of a herbal medicine, yokukansan, in aged rats : involvement of serotonergic and dopaminergic transmissions in the prefrontal cortex.2010

Author(s)

Journal Title

Data Source

[Journal Article] ストレスと認知症2010

Author(s)

Journal Title

Data Source

[Journal Article] Age-related spatial working memory impairment is caused by prefrontal cortical dopaminergic dysfunction in rats.2009

Author(s)

Journal Title

Data Source

[Journal Article] Saikokaryukotsuboreito, a herbal medicine, prevents chronic stress-induced anxiety in rats: comparison with diazepam2009

Author(s)

Journal Title

NAID

Data Source

[Journal Article] ストレスと柴胡加竜骨牡蛎湯2009

Author(s)

Journal Title

Data Source

[Journal Article] Influence of aging on chondroitin sulfate proteoglycan expression and neural stem/progenitor cells in rat brain and improving effects of a herbal medicine, yokukansan.2009

Author(s)

Journal Title

Data Source

[Journal Article] Saikokaryukotsuboreito, a herbal medicine, prevents chronic stress-induced anxiety in rats : comparison with diazepam2009

Author(s)

Journal Title

NAID

Data Source

[Journal Article] Persistent depressive state after chronic stress in rats is accompanied by HPA axis dysregulation and reduced prefrontal dopaminergic neurotransmission2008

Author(s)

Journal Title

Data Source

[Journal Article] Suppression of glucocorticoid secretion enhances cholinergic transmission in rat hippocampus2008

Author(s)

Journal Title

Data Source

[Journal Article] Suppression of glucocorticoid secretion induces a behaviorally depressive state in rotarod performance in rat2008

Author(s)

Journal Title

Data Source

[Journal Article] Suppression of glucocorticoid secretion enhances cholinergic transmission in rat hippocampus2008

Author(s)

Journal Title

Data Source

[Journal Article] Suppression of glucocorticoid secretion induces a behaviorally depressive state in rotarod performance in rat2008

Author(s)

Journal Title

Data Source

[Journal Article] Aging attenuates glucocorticoid negative feedback in rat brain2008

Author(s)

Journal Title

Data Source

[Journal Article] Persistent depressive state after chronic stress in rats is accompanied by HPA axis dysregulation and reduced prefrontal dopamhergic neurotransmission2008

Author(s)

Journal Title

Data Source

[Journal Article] Saikokaryukotsuboreito, a herbal medicine, prevents chronic stress-induced dysfunction of glucocorticoid negative feedback system in rat brain2007

Author(s)

MIZOGUCHI Kazushige 溝口和臣