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MIZOGUCHI Kazushige  溝口 和臣

ORCIDConnect your ORCID iD *help
Researcher Number 20416176
Affiliation (based on the past Project Information) *help 2010: 独立行政法人国立長寿医療研究センター, その他
2009: National Institute for Longevity Sciences,NCGG, 老年病研究部・東洋医学研究室, 室長
2008: National Institute for Longevity Sciences,NCGG, 老年病研究部, 室長
2007 – 2008: National Institute for Longevity Sciences,NCGG, 老年病研究部・東洋医学研究室, 室長
2006: 国立長寿医療センター, (研究所)・老年病研究部・東洋医学研究室, 室長
Review Section/Research Field
Principal Investigator
General internal medicine (including Psychosomatic medicine)
Keywords
Principal Investigator
ラット / セロトニン / ドーパミン / 前頭前野 / ストレス / 老化 / 扁桃体 / ストレス脆弱性 / 視床下部-下垂体-副腎皮質系 / グルココルチコイド … More / 視床下部-下垂体-副腎軸 / 脳 / グルココルチコイド受容体 / うつ病 Less
  • Research Projects

    (2 results)
  • Research Products

    (29 results)
  • Co-Researchers

    (3 People)
  •  老化による前頭前野の機能低下とストレス脆弱性の発生機構Principal Investigator

    • Principal Investigator
      溝口 和臣
    • Project Period (FY)
      2009 – 2011
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      General internal medicine (including Psychosomatic medicine)
    • Research Institution
      National Center for Geriatrics and Gerontology
  •  Common factor(s) involving vulnerability to stress and pathophysiology of depression in the elderlyPrincipal Investigator

    • Principal Investigator
      MIZOGUCHI Kazushige
    • Project Period (FY)
      2006 – 2008
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      General internal medicine (including Psychosomatic medicine)
    • Research Institution
      National Institute for Longevity Sciences,NCGG

All 2010 2009 2008 2007 Other

All Journal Article Presentation

  • [Journal Article] Acute and repeated stress differentially regulates behavioral, endocrine, neural parameters relevant to emotional and stress response in young and aged rats.2010

    • Author(s)
      Shoji H, Mizoguchi K
    • Journal Title

      Behav.Brain Res. 211

      Pages: 169-177

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21590781
  • [Journal Article] Anxiolytic effect of a herbal medicine, yokukansan, in aged rats : involvement of serotonergic and dopaminergic transmissions in the prefrontal cortex.2010

    • Author(s)
      Mizoguchi K, Tanaka Y, Tabira T.
    • Journal Title

      J.Ethnopharmacol. 127

      Pages: 70-76

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21590781
  • [Journal Article] ストレスと認知症2010

    • Author(s)
      溝口和臣
    • Journal Title

      認知症診療マニュアル 72(suppl.6)

      Pages: 57-61

    • Data Source
      KAKENHI-PROJECT-21590781
  • [Journal Article] Age-related spatial working memory impairment is caused by prefrontal cortical dopaminergic dysfunction in rats.2009

    • Author(s)
      Mizoguchi K, Shoji H, Tanaka Y, Maruyama W, Tabira T
    • Journal Title

      Neuroscience 162

      Pages: 1192-1201

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21590781
  • [Journal Article] Saikokaryukotsuboreito, a herbal medicine, prevents chronic stress-induced anxiety in rats: comparison with diazepam2009

    • Author(s)
      Mizoguchi K, Ikeda R, Shoji H, Tanaka Y Jin XL, Kase Y, Takeda S, Maruyama W, Tabira T
    • Journal Title

      Nat. Med. (Tokyo) 63

      Pages: 69-74

    • NAID

      10025825655

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-18590663
  • [Journal Article] ストレスと柴胡加竜骨牡蛎湯2009

    • Author(s)
      溝口和臣
    • Journal Title

      薬局 60

      Pages: 130-134

    • Data Source
      KAKENHI-PROJECT-21590781
  • [Journal Article] Influence of aging on chondroitin sulfate proteoglycan expression and neural stem/progenitor cells in rat brain and improving effects of a herbal medicine, yokukansan.2009

    • Author(s)
      Tanaka Y, Mizoguchi K.
    • Journal Title

      Neuroscience 164

      Pages: 1224-1234

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21590781
  • [Journal Article] Saikokaryukotsuboreito, a herbal medicine, prevents chronic stress-induced anxiety in rats : comparison with diazepam2009

    • Author(s)
      Mizoguchi K., et al.
    • Journal Title

      Nat. Med. (Tokyo) 63

      Pages: 69-74

    • NAID

      10025825655

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-18590663
  • [Journal Article] Persistent depressive state after chronic stress in rats is accompanied by HPA axis dysregulation and reduced prefrontal dopaminergic neurotransmission2008

    • Author(s)
      Mizoguchi K., et al.
    • Journal Title

      Pharmacol. Biochem. Behav. 91

      Pages: 170-175

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-18590663
  • [Journal Article] Suppression of glucocorticoid secretion enhances cholinergic transmission in rat hippocampus2008

    • Author(s)
      Mizoguchi K, Shoji H, Ikeda R, Tanaka Y, Maruyama W, Tabira T
    • Journal Title

      Brain Res. Bull. 76

      Pages: 612-615

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-18590663
  • [Journal Article] Suppression of glucocorticoid secretion induces a behaviorally depressive state in rotarod performance in rat2008

    • Author(s)
      Mizoguchi K, Ikeda R, Shoji H, Tanaka Y, Tabira T
    • Journal Title

      Pharmacol Biochem. Behav. 90

      Pages: 730-734

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-18590663
  • [Journal Article] Suppression of glucocorticoid secretion enhances cholinergic transmission in rat hippocampus2008

    • Author(s)
      Mizoguchi K., et al.
    • Journal Title

      Brain Res. Bull. 76

      Pages: 612-615

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-18590663
  • [Journal Article] Suppression of glucocorticoid secretion induces a behaviorally depressive state in rotarod performance in rat2008

    • Author(s)
      Mizoguchi K., et al.
    • Journal Title

      Pharmacol. Biochem. Behav. 90

      Pages: 730-734

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-18590663
  • [Journal Article] Aging attenuates glucocorticoid negative feedback in rat brain2008

    • Author(s)
      Mizoguchi K., et al.
    • Journal Title

      Neuroscience 159

      Pages: 270-259

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-18590663
  • [Journal Article] Persistent depressive state after chronic stress in rats is accompanied by HPA axis dysregulation and reduced prefrontal dopamhergic neurotransmission2008

    • Author(s)
      Mizoguchi K, Shoji H, Ikeda R, Tanaka Y, Tabira T
    • Journal Title

      Pharmacol. Biochem. Behav. 91

      Pages: 170-175

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-18590663
  • [Journal Article] Saikokaryukotsuboreito, a herbal medicine, prevents chronic stress-induced dysfunction of glucocorticoid negative feedback system in rat brain2007

    • Author(s)
      Mizoguchi K, Sun N, Jin XL, Kase Y, Takeda S, Maruyama W, Tabira T
    • Journal Title

      Pharmacol. Biochem. Behav. 86

      Pages: 55-61

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-18590663
  • [Journal Article] Saikokaryukotsuboreito, a herbal medicine, prevents chronic stress-induced dysfunction of glucocorticoid negative feedback system in rat brain.2007

    • Author(s)
      Mizoguchi K., et. al.
    • Journal Title

      Pharmacol. Biochem. Behav. 86

      Pages: 55-61

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-18590663
  • [Journal Article] Effect of intracranial hypertension on cerebral hemorrhage induced autonomic nerve imbalance2007

    • Author(s)
      Jin XL, Jing W, Yan F, Zhang Z, Lu F, Jing S, Sun N, Mizoguchi K
    • Journal Title

      Neural Regen. Res. 2

      Pages: 175-178

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-18590663
  • [Journal Article] Saikokaryukotsuboreito, a herbal medicine, prevents chronic stress-induced dysfunction of glucocorticoid negative feedback system in rat brain.2007

    • Author(s)
      Mizoguchi K, Sun N, Jin XL, Kase Y, Takeda S, Maruyama W, Tabira T
    • Journal Title

      Pharmacol.Biochem.Behav. 86・1

      Pages: 55-61

    • Data Source
      KAKENHI-PROJECT-18590663
  • [Journal Article] Suppression of glucocorticoid secretion enhances cholinergic transmission in rat hippocampus.

    • Author(s)
      Mizoguchi K., et. al.
    • Journal Title

      Brain Res. Bull. (in press)

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-18590663
  • [Journal Article] Systemic disorders of calcium dynamics in rats with adenine-induced renal failure : implication for chronic kidney disease-related complications

    • Author(s)
      Ikeda R, Imai Y, Maruyama W, Mizoguchi K.
    • Journal Title

      Nephrology (印刷中)

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-18590663
  • [Journal Article] Systemic disorders of calcium dynamics in rats with adenine-induced renal failure : implication for chronic kidney disease-related complications

    • Author(s)
      Ikeda R, Imai Y, Maruyama W, Mizoguchi K
    • Journal Title

      Nephrology (in press)

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-18590663
  • [Journal Article] Age-related spatial working memory impairment is caused by prefrontal cortical dopaminergic dysfunction in rats

    • Author(s)
      Mizoguchi K, Ikeda R, Shoii H, Tanaka Y, Maruyama W, Tabira T
    • Journal Title

      Neuroscience (in press)

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-18590663
  • [Journal Article] Hachimijiogan (Ba-Wei-Di-Huang-Wan), a herbal medicine, improves unbalance of calcium metabolism in aged rats

    • Author(s)
      Ikeda R, Mizoguchi K.
    • Journal Title

      J. Ethnopharmacol (印刷中)

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-18590663
  • [Journal Article] Hachimijiogan (Ba- Wei-Di-Huang- Wan), a herbal medicine, improves unbalance of calcium metabolism in aged rats

    • Author(s)
      Ikeda R, Mizoguchi K
    • Journal Title

      J. Ethnopharmacol. (in press)

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-18590663
  • [Journal Article] Aging attenuates glucocorticoid negative feedback in rat brain

    • Author(s)
      Mizoguchi K, Ikeda R, Shoji H, Tanaka Y, Maruyama W, Tabira T
    • Journal Title

      Neuroscience 159

      Pages: 259-270

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-18590663
  • [Presentation] 情動行動と内分泌反応を指標とした老齢ラットのストレス脆弱性とその脳内機構の検討2009

    • Author(s)
      昌子浩孝、溝口和臣
    • Organizer
      第69回日本動物心理学会大会
    • Place of Presentation
      岐阜大学(岐阜県)
    • Year and Date
      2009-09-26
    • Data Source
      KAKENHI-PROJECT-21590781
  • [Presentation] 加齢による前頭前野の機能低下と漢方薬による改善作用(基礎)2008

    • Author(s)
      溝口和臣, 池田龍史, 昌子浩孝, 田中弥生, 丸山和佳子, 田平武
    • Organizer
      第8回抗加齢医学会総会(シンポジウム)
    • Place of Presentation
      東京
    • Year and Date
      2008-06-07
    • Data Source
      KAKENHI-PROJECT-18590663
  • [Presentation] 柴胡加竜骨牡蛎湯の抗うつ作用2007

    • Author(s)
      溝口和臣
    • Organizer
      第25回泌尿器科漢方研究会
    • Place of Presentation
      神戸
    • Year and Date
      2007-04-14
    • Data Source
      KAKENHI-PROJECT-18590663
  • 1.  SUN Nan (60419900)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 3 results
  • 2.  IKEDA Ryuji (80463199)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 11 results
  • 3.  SHOJI Hirotaka (00466278)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 6 results

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