Nakanishi Takeshi 中西猛

… Alternative Names

NAKANISHI Takeshi 中西猛

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Researcher Number	20422074
Other IDs
Affiliation (Current)	2025: 大阪公立大学, 大学院工学研究科, 准教授
Affiliation (based on the past Project Information) *help	2022 – 2023: 大阪公立大学, 大学院工学研究科, 准教授 2018 – 2021: 大阪市立大学, 大学院工学研究科, 准教授 2014 – 2017: 大阪市立大学, 大学院工学研究科, 講師 2016: 大阪市立大学, 大学院・工学研究科, 講師 2011 – 2013: 大阪市立大学, 工学(系)研究科(研究院), 講師 … More 2012: 大阪市立大学, 大学院・工学研究科, 講師 2010: 大阪市立大学, 大学院・工学研究科, 講師 2009: 大阪市立大学, 大学院・工学研究科, 特任講師 Less
Review Section/Research Field	Principal Investigator Drug development chemistry / Basic Section 27040:Biofunction and bioprocess engineering-related / Biofunction/Bioprocess / Living organism molecular science Except Principal Investigator Basic Section 90120:Biomaterials-related / Basic Section 26050:Material processing and microstructure control-related / Physical chemistry / Applied biochemistry
Keywords	Principal Investigator タンパク質工学 / 抗体 / 分子認識 / 受容体 / ペプチド移植 / ペプチドリンカー / 共通軽鎖 / 抗体フォーマット / 二重特異性抗体 / 抗体医薬 … More / バイオテクノロジー / 蛋白質 / 遺伝子 / バイオ医薬 / 酵素 / リガンド / 人工結合タンパク質 / ファージディスプレイ / RNA分解酵素 … More Except Principal Investigator デンドリマー / EGFR / ドラッグデリバリー / ＤＤＳ / 中性子捕捉療法 / 担がんマウス / インビボイメージング / 抗体 / ドラッグデリバリーシステム / 体内動態 / 腫瘍増殖抑制効果 / 腫瘍集積 / 二重特異性抗体 / ホウ素中性子捕捉療法 / バイオフィルム / 電気化学分析 / 蛍光X線分析 / メタ遺伝子解析 / 微生物腐食 / セリンヒドロキシメチル転移酵素 / D-アミノ酸酸化酵素 / 蛋白質構造異性 / d-アミノ酸酸化酵素 / 機能阻害効果 / 蛋白質・酵素 / 時間分解蛍光 / 分子分光 / 国際情報交換 / 補因子 / 構造機能相関 / タンパク質工学 / フラボタンパク質 Less

Fc領域ヘテロ会合化を必要としない非対称二重特異性抗体の作製技術開発Principal Investigator
- Principal Investigator
  
  中西猛
- Project Period (FY)
  2022 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 27040:Biofunction and bioprocess engineering-related
- Research Institution
  Osaka Metropolitan University
Development of BNCT Boron Delivery System by Using Bispecific Antibody
- Principal Investigator
  
  Nagasaki Takeshi
- Project Period (FY)
  2019 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 90120:Biomaterials-related
- Research Institution
  Osaka Metropolitan University
  Osaka City University
Studies on microbiologically influenced corrosion mechanisms by spatial - temporal imaging of an internal environment of biofilm
- Principal Investigator
  
  Kawakami Hiroshi
- Project Period (FY)
  2018 – 2021
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 26050:Material processing and microstructure control-related
- Research Institution
  Osaka City University
Development of an advanced protein linking technology for generating innovative biopharmaceuticalsPrincipal Investigator
- Principal Investigator
  
  NAKANISHI Takeshi
- Project Period (FY)
  2017 – 2019
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Drug development chemistry
- Research Institution
  Osaka City University
Multiple analysis of FMN-binding reaction and consideration on molecular evolution based on structural information
- Principal Investigator
  
  KITAMURA Masaya
- Project Period (FY)
  2014 – 2016
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Applied biochemistry
- Research Institution
  Osaka City University
Study on function inhibitory effect of protein by time-resolved fluorescence measurement
- Principal Investigator
  
  TANIGUCHI SEIJI
- Project Period (FY)
  2014 – 2016
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Physical chemistry
- Research Institution
  Institute for Laser Technology
Development of a molecular connection method for generating highly functional antibodiesPrincipal Investigator
- Principal Investigator
  
  NAKANISHI TAKESHI
- Project Period (FY)
  2013 – 2015
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Biofunction/Bioprocess
- Research Institution
  Osaka City University
Development of a highly efficient method for generating functional antibodies based on grafting natural ligandsPrincipal Investigator
- Principal Investigator
  
  NAKANISHI Takeshi
- Project Period (FY)
  2011 – 2012
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Drug development chemistry
- Research Institution
  Osaka City University
ボトムアップ的ライブラリー構築による抗体様RNA分解酵素の創製Principal Investigator
- Principal Investigator
  
  中西猛
- Project Period (FY)
  2009 – 2010
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Living organism molecular science
- Research Institution
  Osaka City University

All 2023 2022 2021 2020 2019 2018 2017 2016 2015 2013 2012 2011 2009 Other

All Journal Article Presentation Book

[Book] 次世代医薬開発に向けた抗体工学の最前線(ファージ提示系による親和性の向上)2012
- Author(s)
  中西猛,真田英明,熊谷泉
- Publisher
  シーエムシー出版
- Data Source
  KAKENHI-PROJECT-23790136
[Book] 次世代医薬開発に向けた抗体工学の最前線(ファージ提示系による親和性の向上)2012
- Author(s)
  中西猛
- Publisher
  シーエムシー出版
- Data Source
  KAKENHI-PROJECT-23790136
[Journal Article] Cancer therapeutic trispecific antibodies recruiting both T and natural killer cells to cancer cells2023
- Author(s)
  Kouki Kimura, Atsushi Kuwahara, Saori Suzuki, Takeshi Nakanishi, Izumi Kumagai, and Ryutaro Asano
- Journal Title
  
  Oncology Reports
  
  Volume: 50 Issue: 6 Pages: 212-212
- DOI
  10.3892/or.2023.8649
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-22K04846, KAKENHI-PROJECT-23K24176
[Journal Article] Construction of IgG-Fab2 bispecific antibody via intein-mediated protein trans-splicing reaction2023
- Author(s)
  Risa Yamada, Ishin Nakahara, Izumi Kumagai, Ryutaro Asano, Takeshi Nakanishi, and Koki Makabe
- Journal Title
  
  Scientific Reports
  
  Volume: 13 Issue: 1 Pages: 15961-15961
- DOI
  10.1038/s41598-023-43110-0
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-22K04846, KAKENHI-PROJECT-23K24176
[Journal Article] Generation of Rat Monoclonal Antibodies Against Human Epidermal Growth Factor Receptor 22023
- Author(s)
  Yamamoto Honoka、Nakanishi Takeshi、Ihara Kan-ichiro、Tachibana Taro、Yokoyama Chikako
- Journal Title
  
  Monoclonal Antibodies in Immunodiagnosis and Immunotherapy
  
  Volume: 42 Issue: 2 Pages: 59-64
- DOI
  10.1089/mab.2022.0042
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22K04846, KAKENHI-PROJECT-20K07583
[Journal Article] Chemically Crosslinked Bispecific Antibodies for Cancer Therapy: Breaking from the Structural Restrictions of the Genetic Fusion Approach2020
- Author(s)
  Ueda Asami, Umetsu Mitsuo, Nakanishi Takeshi, Hashikami Kentaro, Nakazawa Hikaru, Hattori Shuhei, Asano Ryutaro, Kumagai Izumi
- Journal Title
  
  Int. J. Mol. Sci.
  
  Volume: 21 Issue: 3 Pages: 711-714
- DOI
  10.3390/ijms21030711
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K04842, KAKENHI-PROJECT-17K08368, KAKENHI-PROJECT-19H03511, KAKENHI-PROJECT-20H00315
[Journal Article] Build-up Functionalization of anti-EGFR × anti-CD3 Bispecific Diabodies by Integrating High-Affinity Mutants and Functional Molecular Formats.2020
- Author(s)
  Asano R, Hosokawa K, Taki S, Konno S, Shimomura I, Ogata H, Okada M, Arai K, Nakanishi T, Onitsuka M, Omasa T, Umetsu M, Kumagai I.
- Journal Title
  
  Sci. Rep.
  
  Volume: 10(1) Issue: 1 Pages: 4913-4913
- DOI
  10.1038/s41598-020-61840-3
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19KK0194, KAKENHI-PROJECT-17K08368, KAKENHI-PROJECT-19H03511
[Journal Article] Construction of a Circularly Connected VHH Bispecific Antibody (Cyclobody) for the Desirable Positioning of Antigen-Binding Sites.2020
- Author(s)
  Hemmi S, Asano R, Kimura K, Umetsu M, TNakanishi T, Kumagai I, Makabe K.
- Journal Title
  
  Biochem. Biophys. Res. Commun.
  
  Volume: 523(1) Issue: 1 Pages: 72-77
- DOI
  10.1016/j.bbrc.2019.12.018
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19KK0194, KAKENHI-PROJECT-17K08368, KAKENHI-PROJECT-19H03511, KAKENHI-PROJECT-20H00315
[Journal Article] Preparation and Characterization of a Novel Bispecific Antibody That Targets Her2 and BSH for Boron Neutron Capture Therapy2020
- Author(s)
  Taisei Kanai, Taro Tachibana, Takeshi Nakanishi, Mitsunori Kirihata, Yoshihide Hattori, Yu Sanada, Yoshinori Sakurai, Shin-ichiro Masunaga
- Journal Title
  
  KURNS Progress Report 2019
  
  Volume: -
- Data Source
  KAKENHI-PROJECT-19H04472
[Journal Article] Generation of the Rat Monoclonal Antibody Against the Extracellular Domain of Human CD63 by DNA Immunization2020
- Author(s)
  Xu Liu、Ihara Kan-ichiro、Yoshimura Saori、Konno Daijiro、Tachibana Akira、Nakanishi Takeshi、Tachibana Taro
- Journal Title
  
  Monoclonal Antibodies in Immunodiagnosis and Immunotherapy
  
  Volume: - Issue: 3 Pages: 74-76
- DOI
  10.1089/mab.2020.0007
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K07776, KAKENHI-PROJECT-17K08368, KAKENHI-PROJECT-20K12651
[Journal Article] Soluble expression in Escherichia coli of a single-domain antibody-tumor necrosis factor α fusion protein specific for epidermal growth factor receptor.2018
- Author(s)
  Tomohiro Osaki, Takeshi Nakanishi, Motoshi Aoki, Takahiro Omizu, Daisuke Nishiura, Masaya Kitamura
- Journal Title
  
  Monoclon. Antib. Immunodiagn. Immunother.
  
  Volume: 37 Issue: 1 Pages: 20-25
- DOI
  10.1089/mab.2017.0051
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17K08368
[Journal Article] Affinity maturation of humanized anti-epidermal growth factor receptor antibody using a modified phage-based open sandwich selection method.2018
- Author(s)
  Hideaki Sanada, Kazuki Kobayashi, Takamitsu Maru, Takeshi Nakanishi, Mitsuo Umetsu, Ryutaro Asano, Izumi Kumagai
- Journal Title
  
  Sci. Rep.
  
  Volume: 8 Issue: 1 Pages: 5414-5414
- DOI
  10.1038/s41598-018-23796-3
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K08368, KAKENHI-PROJECT-15H04306
[Journal Article] Photoinduced electron transfer from aromatic amino acids to the excited isoalloxazine in single mutated flavin mononucleotide binding proteins: Effect of the dimer formation on the rate and the electrostatic energy inside the proteins2017
- Author(s)
  Nadtanet Nunthaboot,Kiattisak Lugsanangarm, Arthit Nueangaudom, Somsak Pianwanit ,Sirirat Kokpol, Fumio Tanaka, Seiji Taniguchi, Haik Chosrowjan, Takeshi Nakanishi, Masaya Kitamura
- Journal Title
  
  Computational and Theoretical Chemistry
  
  Volume: 1108 Pages: 1-9
- DOI
  10.1016/j.comptc.2017.03.005
- Peer Reviewed / Acknowledgement Compliant / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26410029, KAKENHI-PROJECT-26450131
[Journal Article] Photoinduced electron transfer from aromatic amino acids to the excited isoalloxazine in flavin mononucleotide binding protein. Is the rate in the inverted region of donor – acceptor distance not real?2016
- Author(s)
  N. Nunthaboot, K. Lugsanangarm, A. Nueangaudom, S. Pianwanit, S. Kokpol, F. Tanaka, S. Taniguchi, H. Chosrowjan, T. Nakanishi, M. Kitamura
- Journal Title
  
  Journal of Photochemistry and Photobiology A: Chemistry
  
  Volume: 326 Pages: 60-68
- DOI
  10.1016/j.jphotochem.2016.04.005
- Peer Reviewed / Acknowledgement Compliant / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26410029, KAKENHI-PROJECT-26450131
[Journal Article] Conformational Difference between Two Subunits in Flavin Mononucleotide Binding Protein Dimers from Desulfovibrio vulgaris (MF): Molecular Dynamics Simulation2016
- Author(s)
  Nadtanet Nunthaboot, Kiattisak Lugsanangarm, Somsak Pianwanit, Sirirat Kokpol, Fumio Tanaka, Takeshi Nakanishi, Masaya Kitamura
- Journal Title
  
  Computational Biology and Chemistry
  
  Volume: 64 Pages: 113-125
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26450131
[Journal Article] Generation and characterization of rat monoclonal antibodies against epidermal growth factor receptor.2015
- Author(s)
  Tomohiro Osaki, Cai-Xia Wang, Taro Tachibana, Masayuki Azuma, Masaya Kitamura, Takeshi Nakanishi
- Journal Title
  
  Monoclon. Antib. Immunodiagn. Immunother.
  
  Volume: 34 Issue: 6 Pages: 418-422
- DOI
  10.1089/mab.2015.0034
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-25420836
[Journal Article] Development of a bispecific antibody tetramerized through hetero-associating peptides.2015
- Author(s)
  Tomohiro Osaki, Shingo Fujisawa, Masahiro Kitaguchi, Masaya Kitamura, Takeshi Nakanishi
- Journal Title
  
  FEBS J.
  
  Volume: 282 Issue: 22 Pages: 4389-4401
- DOI
  10.1111/febs.13505
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-25420836
[Journal Article] Development of an affinity-matured humanized anti-epidermal growth factor receptor antibody for cancer immunotherapy.2013
- Author(s)
  Takeshi Nakanishi, et al.
- Journal Title
  
  Protein Engineering Design and Selection
  
  Volume: 26 Issue: 2 Pages: 113-122
- DOI
  10.1093/protein/gzs088
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23686118, KAKENHI-PROJECT-23790136, KAKENHI-PROJECT-24000011
[Journal Article] Development of an affinity-matured humanized anti-epidermal growth factor receptor antibody for cancer immunotherapy2013
- Author(s)
  Takeshi Nakanishi, Takamitsu Maru, Kazuhiro Tahara, Hideaki Sanada, Mitsuo Umetsu, Ryutaro Asano, and Izumi Kumagai
- Journal Title
  
  Protein Eng. Des. Sel
  
  Volume: 26 Pages: 113-122
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23790136
[Journal Article] Construction and humanization of a functional bispecific EGFR × CD16 diabody using a refolding system2012
- Author(s)
  Ryutaro Asano, Makoto Nakayama, Hiroko Kawaguchi, Tsuguo Kubota, Takeshi Nakanishi, Mitsuo Umetsu, Hiroki Hayashi, Yu Katayose, Michiaki Unno, Toshio Kudo, and Izumi Kumagai
- Journal Title
  
  FEBS J
  
  Volume: 279 Pages: 223-233
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23790136
[Journal Article] A high-affinity gold-binding camel antibody: Antibody engineering for one-pot functionalization of gold nanoparticles as biointerface molecules2012
- Author(s)
  Takamitsu Hattori, Mitsuo Umetsu, Takeshi Nakanishi, Satoko Sawai, Shinsuke Kikuchi, Ryutaro Asano, and Izumi Kumagai
- Journal Title
  
  Bioconjug. Chem
  
  Volume: 23 Pages: 1934-1944
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23790136
[Journal Article] Cytotoxic enhancement of a bispecific diabody (Db) by format conversion to tandem single-chain variable fragment (taFv): THE CASE OF THE hEx3 DIABODY.2011
- Author(s)
  Ryutaro Asano, Keiko Ikoma, Ippei Shimomura, Shintaro Taki, Takeshi Nakanishi, Mitsuo Umetsu, and Izumi Kumagai
- Journal Title
  
  J. Biol. Chem
  
  Volume: 286 Pages: 1812-1818
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23790136
[Journal Article] Biomimetic engineering of modular bispecific antibodies for biomolecule immobilization2011
- Author(s)
  Hideki Watanabe, Kengo Kanazaki, Takeshi Nakanishi, Hidenori Shiotsuka, Satoru Hatakeyama, Masaru Kaieda, Takeshi Imamura, Mitsuo Umetsu, and Izumi Kumagai
- Journal Title
  
  Langmuir
  
  Volume: 27 Pages: 9656-9661
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23790136
[Journal Article] In vitro and in vivo antitumor effects of recombinant bispecific antibodies based on humanized anti-EGFR antibody2011
- Author(s)
  Yasuhiro Watanabe, Ryutaro Asano, Kyoko Arai, Ippei Shimomura, Hiromi Ogata, Hiroko Kawaguchi, Hiroki Hayashi, Hideo Ohtsuka, Hiroshi Yoshida, Yu Katayose, Shinichi Egawa, Takeshi Nakanishi, Mitsuo Umetsu, Hiroshi Yasui, Tadao Ishida, Kohzoh I
- Journal Title
  
  Oncol. Rep
  
  Volume: 26 Pages: 949-955
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23790136
[Presentation] 高効率精製に向けたIgG型二重特異性抗体のカッパボディを利用した設計2023
- Author(s)
  松本凌央、北村昌也、中西猛
- Organizer
  BioMedical Forum 2023
- Data Source
  KAKENHI-PROJECT-22K04846
[Presentation] 二重特異性抗体デザインにおけるIgドメインの連結2023
- Author(s)
  中西猛
- Organizer
  第２回日本抗体学会学術大会
- Data Source
  KAKENHI-PROJECT-22K04846
[Presentation] 非対称フォーマットを利用した二重特異性T細胞リクルート抗体の設計2023
- Author(s)
  小幡匡、福田小夏、北村昌也、中西猛
- Organizer
  BioMedical Forum 2024
- Data Source
  KAKENHI-PROJECT-22K04846
[Presentation] 大腸菌発現系を用いたタンデムdsFv型バイパラトピック抗体の作製2023
- Author(s)
  豊田拓海、真壁幸樹、北村昌也、中西猛
- Organizer
  BioMedical Forum 2023
- Data Source
  KAKENHI-PROJECT-22K04846
[Presentation] 3本鎖構造に基づく非対称IgG型二重特異性抗体の設計2023
- Author(s)
  森田知樹、北村昌也、中西猛
- Organizer
  BioMedical Forum 2024
- Data Source
  KAKENHI-PROJECT-22K04846
[Presentation] 3本鎖構造を利用した非対称IgG型二重特異性抗体の構築2023
- Author(s)
  森田知樹、北村昌也、中西猛
- Organizer
  第２回日本抗体学会学術大会
- Data Source
  KAKENHI-PROJECT-22K04846
[Presentation] Bispecific antibody against BSH and Her2 for Boron Neutron Capture Therapy2023
- Author(s)
  T. Nagasaki, A. Tabata, T. Kanai, T. Tachibana, T. Nakanishi, R. Kawasaki, Y. Sakurai, Y. Sanada
- Organizer
  2023 Taiwan-Japan Neutron Capure Therapy Academic Conference of Elite
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19H04472
[Presentation] 次世代バイオ創薬のための抗体デザイン研究2023
- Author(s)
  中西猛
- Organizer
  BioMedical Forum 2023
- Data Source
  KAKENHI-PROJECT-22K04846
[Presentation] 非対称フォーマットを利用した二重特異性T細胞リクルート抗体の構築2023
- Author(s)
  小幡匡、福田小夏、北村昌也、中西猛
- Organizer
  第２回日本抗体学会学術大会
- Data Source
  KAKENHI-PROJECT-22K04846
[Presentation] 免疫チェックポイント分子を融合したプロドラッグ抗体の開発2023
- Author(s)
  五十川藍、北村昌也、中西猛
- Organizer
  第２回日本抗体学会学術大会
- Data Source
  KAKENHI-PROJECT-22K04846
[Presentation] 酵素融合抗体を用いたタウ検出系の構築2023
- Author(s)
  前田大成、朝山晃、神所真佑、立花太郎、北村昌也、中西猛
- Organizer
  BioMedical Forum 2023
- Data Source
  KAKENHI-PROJECT-22K04846
[Presentation] 免疫チェックポイント分子を融合した二重特異性プロドラッグ抗体の開発2023
- Author(s)
  五十川藍、北村昌也、中西猛
- Organizer
  BioMedical Forum 2024
- Data Source
  KAKENHI-PROJECT-22K04846
[Presentation] 二重特異性抗体を用いたBNCTホウ素デリバリー2023
- Author(s)
  田畑杏梨、金井大成、河﨑陸、櫻井良憲、真田悠生、立花太郎、中西猛、長﨑健
- Organizer
  BioMedical Forum ２０２３
- Data Source
  KAKENHI-PROJECT-19H04472
[Presentation] 担がんマウスにおけるBSHとHer2に対する二重特異性抗体の腫瘍集積性とBNCT効果2022
- Author(s)
  長﨑　健、田畑杏梨、金井大成、河﨑陸、櫻井良憲、真田悠生、立花太郎、中西猛
- Organizer
  第18回日本中性子捕捉療法学会
- Data Source
  KAKENHI-PROJECT-19H04472
[Presentation] BSHとHer2に対する二重特異性抗体のBNCTホウ素送達ツールとしての評価2022
- Author(s)
  田畑杏梨、金井大成、河﨑陸、櫻井良憲、真田悠生、立花太郎、中西猛、長﨑健
- Organizer
  遺伝子・デリバリー研究会第２１回シンポジウム、第２０回夏期セミナー
- Data Source
  KAKENHI-PROJECT-19H04472
[Presentation] BSHとHer2に対する二重特異性抗体を用いたホウ素デリバリーとBNCT効果2022
- Author(s)
  田畑杏梨、金井大成、河﨑陸、櫻井良憲、真田悠生、立花太郎、中西猛、長﨑健
- Organizer
  第44回日本バイオマテリアル学会
- Data Source
  KAKENHI-PROJECT-19H04472
[Presentation] Fc領域のヘテロ二量体化を必要としない非対称IgG型二重特異性抗体の構築2022
- Author(s)
  森田知樹、加藤綾人、北村昌也、中西猛
- Organizer
  第１回日本抗体学会設立記念学術大会
- Data Source
  KAKENHI-PROJECT-22K04846
[Presentation] BSH と EGFR に対する二重特異性抗体の機能評価2021
- Author(s)
  吉川浩平、立花太郎、中西猛、長﨑健
- Organizer
  BioMedical Forum 2022
- Data Source
  KAKENHI-PROJECT-19H04472
[Presentation] ホウ素中性子捕捉療法用新規ホウ素薬剤送達ツールとしての二重特異性抗体の抗原認識能2020
- Author(s)
  金井大成、立花太郎、中西　猛、長崎　健
- Organizer
  京都大学複合原子力科学研究所第５４回学術講演会
- Data Source
  KAKENHI-PROJECT-19H04472
[Presentation] ヘテロ会合ペプチドの融合による三重特異性抗体の作製2019
- Author(s)
  角南　哲也，中村　すみれ，中村　亮太，北村　昌也，中西　猛
- Organizer
  第42回日本分子生物学会年会
- Data Source
  KAKENHI-PROJECT-17K08368
[Presentation] がん細胞とエクソソームを標的とする二重特異性抗体の作製2019
- Author(s)
  藤本　裕生，森口　誠也，立花　太郎，立花　亮，北村　昌也，中西　猛
- Organizer
  第42回日本分子生物学会年会
- Data Source
  KAKENHI-PROJECT-17K08368
[Presentation] ホウ素中性子捕捉療法（BNCT）におけるホウ素薬剤送達用二重特異性抗体の作製と機能評価2019
- Author(s)
  金井大成、立花太郎、中西　猛、長崎　健
- Organizer
  第41回日本バイオマテリアル学会
- Data Source
  KAKENHI-PROJECT-19H04472
[Presentation] Effect of Pickling and Mechanical Grinding on Initiation of Biofilm and Microbially Influenced Corrosion of Stainless Steel Weldments2019
- Author(s)
  H. Kawakami, T. Wada, T. Nakanishi, K. Ariyoshi, K. Tsuji, M. Kitamura, and Y. Kikuchi
- Organizer
  NACE East Asia & Pacific Area Conference
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18H01755
[Presentation] 2種のErbB受容体を標的とする二重特異性抗体薬物複合体の作製2019
- Author(s)
  小野　慶祐，中川　里彩，北村　昌也，中西　猛
- Organizer
  第42回日本分子生物学会年会
- Data Source
  KAKENHI-PROJECT-17K08368
[Presentation] ホウ素中性子捕捉療法（BNCT）におけるホウ素薬剤送達に用いる二重特異性抗体の作製2019
- Author(s)
  金井大成、立花太郎、中西　猛、長崎　健
- Organizer
  第13回バイオ関連化学シンポジウム
- Data Source
  KAKENHI-PROJECT-19H04472
[Presentation] タウを標的とするラビットモノクローナル抗体のヒト化2019
- Author(s)
  神所　真佑，立花　太郎，北村　昌也，中西　猛
- Organizer
  第42回日本分子生物学会年会
- Data Source
  KAKENHI-PROJECT-17K08368
[Presentation] ドメイン交換によるIgG様三重特異性T細胞リクルート抗体の改変2018
- Author(s)
  中村　亮太，津村　千尋，北村　昌也，中西　猛
- Organizer
  第41回日本分子生物学会年会
- Data Source
  KAKENHI-PROJECT-17K08368
[Presentation] HER2を標的とするIgG様バイパラトピック抗体薬物複合体の作製2018
- Author(s)
  福富　秀平，池内　祐介，平川　泰史，岩瀬　瑛大，北村　昌也，中西　猛
- Organizer
  第41回日本分子生物学会年会
- Data Source
  KAKENHI-PROJECT-17K08368
[Presentation] シングルドメイン抗体の融合によるIgG様二重特異性T細胞リクルート抗体の構築2018
- Author(s)
  中西　猛，津村　千尋，北村　昌也
- Organizer
  第18回日本蛋白質科学会年会
- Data Source
  KAKENHI-PROJECT-17K08368
[Presentation] がん関連抗原を標的とするIgG様二重特異性T細胞リクルート抗体の作製2017
- Author(s)
  中西猛，津村千尋，北村昌也
- Organizer
  第26回ポリマー材料フォーラム
- Data Source
  KAKENHI-PROJECT-17K08368
[Presentation] HER2を標的とするIgG様二重パラトープ抗体の作製2017
- Author(s)
  池内祐介，平川泰史，岩瀬瑛大，北村昌也，中西猛
- Organizer
  2017年度生命科学系学会合同年次大会
- Data Source
  KAKENHI-PROJECT-17K08368
[Presentation] 2種のがん関連抗原を標的とする三重特異性T細胞リクルート抗体の作製2017
- Author(s)
  中村亮太，津村千尋，北村昌也，中西猛
- Organizer
  2017年度生命科学系学会合同年次大会
- Data Source
  KAKENHI-PROJECT-17K08368
[Presentation] シングルドメイン抗体を利用したIgG様二重特異性抗体の作製2017
- Author(s)
  津村千尋，北村昌也，中西猛
- Organizer
  第17回日本蛋白質科学会年会
- Data Source
  KAKENHI-PROJECT-17K08368
[Presentation] 表面プラズモン共鳴法を用いたFMN 結合反応解析2016
- Author(s)
  山口　亮、張　霜玉、高木　利佳子、中西　猛、北村　昌也
- Organizer
  第16回日本蛋白質科学会年会
- Place of Presentation
  福岡国際会議場（福岡県福岡市）
- Year and Date
  2016-06-07
- Data Source
  KAKENHI-PROJECT-26450131
[Presentation] FMN結合タンパク質の補因子結合反応におけるFMNリン酸基の寄与2016
- Author(s)
  小田　真大、中西　猛、北村　昌也
- Organizer
  第39回日本分子生物学会年会
- Place of Presentation
  パシフィコ横浜（神奈川県横浜市）
- Year and Date
  2016-11-30
- Data Source
  KAKENHI-PROJECT-26450131
[Presentation] Clostridium acetobutylicum ATCC 824 由来FMN 結合タンパク質の生産とその性質2016
- Author(s)
  多良　将吾、張　霜玉、中西　猛、北村　昌也
- Organizer
  第16回日本蛋白質科学会年会
- Place of Presentation
  福岡国際会議場（福岡県福岡市）
- Year and Date
  2016-06-07
- Data Source
  KAKENHI-PROJECT-26450131
[Presentation] 大腸菌発現系によるTNFα融合抗体の作製2015
- Author(s)
  大水貴裕, 大﨑智弘, 青木基, 北村昌也, 中西猛
- Organizer
  BMB2015（第38回日本分子生物学会年会・第88回日本生化学会大会合同大会）
- Place of Presentation
  神戸国際展示場（兵庫県神戸市）
- Year and Date
  2015-12-01
- Data Source
  KAKENHI-PROJECT-25420836
[Presentation] 二重特異性抗体の作製におけるヘテロ会合ペプチドの利用2015
- Author(s)
  中西猛, 大﨑智弘, 藤澤真吾, 北口将大, 北村昌也
- Organizer
  第15回日本蛋白質科学会年会
- Place of Presentation
  あわぎんホール（徳島県徳島市）
- Year and Date
  2015-06-24
- Data Source
  KAKENHI-PROJECT-25420836
[Presentation] Pseudomonas aeruginosa由来フラボドキシンの変異体の性質と構造2015
- Author(s)
  岡田大規、荻野公美子、中西猛、北村昌也
- Organizer
  BMB2015（第38回日本分子生物学会年会・第88回日本生化学会大会合同大会）
- Place of Presentation
  神戸コンベンションセンター（兵庫県神戸市）
- Year and Date
  2015-12-02
- Data Source
  KAKENHI-PROJECT-26450131
[Presentation] リボヌクレアーゼ融合抗体のドメイン構造と機能2013
- Author(s)
  中西猛
- Organizer
  第13回日本蛋白質科学会年会
- Place of Presentation
  とりぎん文化会館（鳥取市）
- Data Source
  KAKENHI-PROJECT-25420836
[Presentation] リボヌクレアーゼ融合抗体の機能におけるドメイン配置の影響2013
- Author(s)
  中西猛
- Organizer
  第65回日本生物工学会大会
- Place of Presentation
  広島国際会議場
- Data Source
  KAKENHI-PROJECT-25420836
[Presentation] チロシン残基に着目した抗ムチン抗体Nd2 の抗原認識機構の解析2012
- Author(s)
  大崎智弘,中西猛,星裕孝,澤田鉄二,木村健二郎,内田素行,平川弘聖,北村昌也
- Organizer
  第85回日本生化学会大会
- Place of Presentation
  福岡国際会議場・マリンメッセ福岡
- Year and Date
  2012-12-16
- Data Source
  KAKENHI-PROJECT-23790136
[Presentation] 単一ドメイン抗体可変領域を用いて設計した RNase 融合抗体の作製と機能評価2012
- Author(s)
  工藤光代,中西猛,北村昌也
- Organizer
  第12回日本蛋白質科学会年会
- Place of Presentation
  名古屋国際会議場
- Year and Date
  2012-06-21
- Data Source
  KAKENHI-PROJECT-23790136
[Presentation] 安定性を高めたヘテロ会合ドメインの利用による抗体の高機能化2012
- Author(s)
  大崎智弘,藤澤真吾,北口将大,北村昌也,中西猛
- Organizer
  第12回日本蛋白質科学会年会
- Place of Presentation
  名古屋国際会議場
- Year and Date
  2012-06-21
- Data Source
  KAKENHI-PROJECT-23790136
[Presentation] ペプチド移植による抗体様RNA 分解酵素の作製2012
- Author(s)
  水巻耕輔,北村昌也,中西猛
- Organizer
  日本農芸化学会2012年度大会
- Place of Presentation
  京都女子大学
- Year and Date
  2012-03-24
- Data Source
  KAKENHI-PROJECT-23790136
[Presentation] ヘテロ会合ペプチドの融合による低分子化抗体の多機能化2011
- Author(s)
  中西猛,藤澤真吾,北村昌也
- Organizer
  第11回日本蛋白質科学会
- Place of Presentation
  ホテル阪急エキスポパーク
- Year and Date
  2011-06-08
- Data Source
  KAKENHI-PROJECT-23790136
[Presentation] EGFRを標的とした RNase 融合抗体の作製2011
- Author(s)
  工藤光代,北村昌也,中西猛
- Organizer
  第11回日本蛋白質科学会
- Place of Presentation
  ホテル阪急エキスポパーク
- Year and Date
  2011-06-08
- Data Source
  KAKENHI-PROJECT-23790136
[Presentation] がん関連抗原を標的とするリボヌクレアーゼ融合抗体の作製と評価2011
- Author(s)
  中西猛,工藤光代,北村昌也
- Organizer
  第84回日本生化学会大会
- Place of Presentation
  京都国際会館
- Year and Date
  2011-09-22
- Data Source
  KAKENHI-PROJECT-23790136
[Presentation] 超高速時間分解蛍光法を用いたFMN結合タンパク質における電子移動反応の解析2009
- Author(s)
  中西猛
- Organizer
  第9回日本蛋白質科学会年会
- Place of Presentation
  熊本全日空ホテルニュースカイ
- Year and Date
  2009-05-22
- Data Source
  KAKENHI-PROJECT-21710236
[Presentation] D-アミノ酸酸化酵素の蛍光ダイナミクス：機能阻害効果の検討
- Author(s)
  谷口誠治、コスロービアンハイク、北村昌也、中西猛、田中文夫
- Organizer
  日本化学会第95春季年会
- Place of Presentation
  日本大学理工学部／薬学部船橋キャンパス
- Year and Date
  2015-03-26 – 2015-03-29
- Data Source
  KAKENHI-PROJECT-26410029
[Presentation] D-アミノ酸酸化酵素のフェムト秒蛍光ダイナミクス：機能阻害効果の検討
- Author(s)
  谷口誠治、コスロービアンハイク、中西猛、北村昌也、田中文夫
- Organizer
  2014光化学討論会
- Place of Presentation
  北海道大学札幌キャンパス
- Year and Date
  2014-10-11 – 2014-10-13
- Data Source
  KAKENHI-PROJECT-26410029
[Presentation] FMN-binding property and crystal structure of YviC from Lactococcus lactis
- Author(s)
  Rikako Takagi, Takeshi Nakanishi, Takuma Maeda, Nobunari Satake, Kentaro Watanabe, Yoshitaka Moriwaki, Tohru Terada, Kentaro Shimizu, and Masaya Kitamura
- Organizer
  IUBMB SYMPOSIUM, 18th International Symposium on Flavins and Flavoproteins
- Place of Presentation
  Phetchaburi (Thailand)
- Year and Date
  2014-07-27 – 2014-08-01
- Data Source
  KAKENHI-PROJECT-26450131

1. KITAMURA Masaya (20244634)

# of Collaborated Projects: 3 results

# of Collaborated Products: 11 results
2. TANIGUCHI SEIJI (00342725)

# of Collaborated Projects: 1 results

# of Collaborated Products: 4 results
3. CHOSROWJAN Haik (70291036)

# of Collaborated Projects: 1 results

# of Collaborated Products: 4 results
4. Kawakami Hiroshi (90305615)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
5. Nagasaki Takeshi (30237507)

# of Collaborated Projects: 1 results

# of Collaborated Products: 4 results
6. 田中文夫 (20022907)

# of Collaborated Projects: 1 results

# of Collaborated Products: 4 results
7. 辻幸一 (30241566)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
8. 有吉欽吾 (80381979)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
9. 立花太郎 (80311752)

# of Collaborated Projects: 1 results

# of Collaborated Products: 11 results
10. 真田悠生 (50738656)

# of Collaborated Projects: 1 results

# of Collaborated Products: 6 results
11. 増永慎一郎 (80238914)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
12. TSUMOTO Kouhei

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
13. 中澤光

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
14. 浅野竜太郎

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results
15. 今野大治郎

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Nakanishi Takeshi 中西 猛

NAKANISHI Takeshi 中西 猛

Research Projects

Research Products

Co-Researchers

Fc領域ヘテロ会合化を必要としない非対称二重特異性抗体の作製技術開発Principal Investigator

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Development of BNCT Boron Delivery System by Using Bispecific Antibody

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Studies on microbiologically influenced corrosion mechanisms by spatial - temporal imaging of an internal environment of biofilm

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Development of an advanced protein linking technology for generating innovative biopharmaceuticalsPrincipal Investigator

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Multiple analysis of FMN-binding reaction and consideration on molecular evolution based on structural information

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Study on function inhibitory effect of protein by time-resolved fluorescence measurement

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Development of a molecular connection method for generating highly functional antibodiesPrincipal Investigator

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Development of a highly efficient method for generating functional antibodies based on grafting natural ligandsPrincipal Investigator

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ボトムアップ的ライブラリー構築による抗体様RNA分解酵素の創製Principal Investigator

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[Book] 次世代医薬開発に向けた抗体工学の最前線(ファージ提示系による親和性の向上)2012

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[Book] 次世代医薬開発に向けた抗体工学の最前線(ファージ提示系による親和性の向上)2012

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[Journal Article] Cancer therapeutic trispecific antibodies recruiting both T and natural killer cells to cancer cells2023

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[Journal Article] Construction of IgG-Fab2 bispecific antibody via intein-mediated protein trans-splicing reaction2023

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[Journal Article] Generation of Rat Monoclonal Antibodies Against Human Epidermal Growth Factor Receptor 22023

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Nakanishi Takeshi 中西猛

NAKANISHI Takeshi 中西猛

[Journal Article] Photoinduced electron transfer from aromatic amino acids to the excited isoalloxazine in flavin mononucleotide binding protein. Is the rate in the inverted region of donor – acceptor distance not real?2016