Tsuji Gaku 辻学

Researcher Number	20423551
Other IDs
Affiliation (Current)	2025: 九州大学, 大学病院, 准教授
Affiliation (based on the past Project Information) *help	2021 – 2022: 九州大学, 大学病院, 准教授 2016 – 2020: 九州大学, 大学病院, 講師 2015: 九州大学, 大学病院, 助教
Review Section/Research Field	Principal Investigator Dermatology / Basic Section 53050:Dermatology-related Except Principal Investigator Basic Section 53050:Dermatology-related
Keywords	Principal Investigator 芳香族炭化水素受容体 / アトピー性皮膚炎 / IL-37 / IL-33 / ovo-like 1 / Ovo-like 1 / 方向族炭化水素受容体 / 上皮成長因子受容体阻害薬 Except Principal Investigator アリル炭化水素容体アゴニスト / フィラグリン / IL-24 / アリル炭化水素受容体

Regulatory mechanism of IL-33 in atopic dermatitisPrincipal Investigator
- Principal Investigator
  
  Tsuji Gaku
- Project Period (FY)
  2020 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 53050:Dermatology-related
- Research Institution
  Kyushu University
アリル炭化水素受容体アゴニストによるアトピー性皮膚炎新規治療薬開発と標的探索
- Principal Investigator
  
  古江増隆
- Project Period (FY)
  2020
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 53050:Dermatology-related
- Research Institution
  Kyushu University
Roles of the AHR-OVOL1 axis in barrier dysfunction of atopic dermatitisPrincipal Investigator
- Principal Investigator
  
  Tsuji Gaku
- Project Period (FY)
  2017 – 2019
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Dermatology
- Research Institution
  Kyushu University
Activation of aryl hydrocarbon receptor-nuclear factor erythroid 2-related factor 2 axis by epidermal growth factor receptor inhibitors: a possible mechanism for acneiform eruptionPrincipal Investigator
- Principal Investigator
  
  Tsuji Gaku
- Project Period (FY)
  2015 – 2016
- Research Category
  
  Grant-in-Aid for Research Activity Start-up
- Research Field
  
  Dermatology
- Research Institution
  Kyushu University

All 2022 2021 2020 2019 2018 2017 2015

All Journal Article Presentation

[Journal Article] Natural Compounds Tapinarof and Galactomyces Ferment Filtrate Downregulate IL-33 Expression via the AHR/IL-37 Axis in Human Keratinocytes2022
- Author(s)
  Tsuji Gaku、Hashimoto-Hachiya Akiko、Matsuda-Taniguchi Tomoyo、Takai-Yumine Ayako、Takemura Masaki、Yan Xianghong、Furue Masutaka、Nakahara Takeshi
- Journal Title
  
  Frontiers in Immunology
  
  Volume: 13
- DOI
  10.3389/fimmu.2022.745997
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K08653
[Journal Article] The Antidiabetic Agent Metformin Inhibits IL-23 Production in Murine Bone-Marrow-Derived Dendritic Cells2021
- Author(s)
  Matsuda-Taniguchi Tomoyo、Takemura Masaki、Nakahara Takeshi、Hashimoto-Hachiya Akiko、Takai-Yumine Ayako、Furue Masutaka、Tsuji Gaku
- Journal Title
  
  Journal of Clinical Medicine
  
  Volume: 10 Issue: 23 Pages: 5610-5610
- DOI
  10.3390/jcm10235610
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K08653
[Journal Article] IL-24 Negatively Regulates Keratinocyte Differentiation Induced by Tapinarof, an Aryl Hydrocarbon Receptor Modulator: Implication in the Treatment of Atopic Dermatitis2020
- Author(s)
  Vu Yen Hai、Hashimoto-Hachiya Akiko、Takemura Masaki、Yumine Ayako、Mitamura Yasutaka、Nakahara Takeshi、Furue Masutaka、Tsuji Gaku
- Journal Title
  
  International Journal of Molecular Sciences
  
  Volume: 21 Issue: 24 Pages: 9412-9412
- DOI
  10.3390/ijms21249412
- Data Source
  KAKENHI-PROJECT-20K08653
[Journal Article] Metformin inhibits IL-1β secretion via impairment of NLRP3 inflammasome in keratinocytes: implications for preventing the development of psoriasis2020
- Author(s)
  Tsuji Gaku、Hashimoto-Hachiya Akiko、Yen Vu Hai、Takemura Masaki、Yumine Ayako、Furue Kazuhisa、Furue Masutaka、Nakahara Takeshi
- Journal Title
  
  Cell Death Discovery
  
  Volume: 6 Issue: 1
- DOI
  10.1038/s41420-020-0245-8
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K10213
[Journal Article] Aryl Hydrocarbon Receptor Activation Downregulates IL-33 Expression in Keratinocytes via Ovo-Like 12020
- Author(s)
  Tsuji Gaku、Hashimoto-Hachiya Akiko、Yen Vu Hai、Miake Sho、Takemura Masaki、Mitamura Yasutaka、Ito Takamichi、Murata Maho、Furue Masutaka、Nakahara Takeshi
- Journal Title
  
  Journal of Clinical Medicine
  
  Volume: 9 Issue: 3 Pages: 891-891
- DOI
  10.3390/jcm9030891
- Data Source
  KAKENHI-PROJECT-20K08653
[Journal Article] Implications of tryptophan photoproduct FICZ in oxidative stress and terminal differentiation of keratinocytes2019
- Author(s)
  Furue Masutaka、Uchi Hiroshi、Mitoma Chikage、Hashimoto-Hachiya Akiko、Tanaka Yuka、Ito Takamichi、Tsuji Gaku
- Journal Title
  
  Giornale Italiano di Dermatologia e Venereologia
  
  Volume: 154 Issue: 1 Pages: 37-41
- DOI
  10.23736/s0392-0488.18.06132-1
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17K10213
[Journal Article] IL-4 Augments IL-31/IL-31 Receptor Alpha Interaction Leading to Enhanced Ccl 17 and Ccl 22 Production in Dendritic Cells: Implications for Atopic Dermatitis2019
- Author(s)
  Miake Sho、Tsuji Gaku、Takemura Masaki、Hashimoto-Hachiya Akiko、Vu Yen Hai、Furue Masutaka、Nakahara Takeshi
- Journal Title
  
  International Journal of Molecular Sciences
  
  Volume: 20 Issue: 16 Pages: 4053-4053
- DOI
  10.3390/ijms20164053
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K10213
[Journal Article] Tryptophan photo-product FICZ upregulates AHR/MEK/ERK-mediated MMP1 expression: Implications in anti-fibrotic phototherapy2018
- Author(s)
  Murai Mika、Yamamura Kazuhiko、Hashimoto-Hachiya Akiko、Tsuji Gaku、Furue Masutaka、Mitoma Chikage
- Journal Title
  
  Journal of Dermatological Science
  
  Volume: 91 Issue: 1 Pages: 97-103
- DOI
  10.1016/j.jdermsci.2018.04.010
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17K10213
[Journal Article] Antioxidative Phytochemicals Accelerate Epidermal Terminal Differentiation via the AHR-OVOL1 Pathway: Implications for Atopic Dermatitis2018
- Author(s)
  Furue M、Hashimoto-Hachiya A、Tsuji G
- Journal Title
  
  Acta Dermato Venereologica
  
  Volume: 98 Issue: 10 Pages: 918-923
- DOI
  10.2340/00015555-3003
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17K10213
[Journal Article] Glyteer, Soybean Tar, Impairs IL-4/Stat6 Signaling in Murine Bone Marrow-Derived Dendritic Cells: The Basis of Its Therapeutic Effect on Atopic Dermatitis2018
- Author(s)
  Takemura Masaki、Nakahara Takeshi、Hashimoto-Hachiya Akiko、Furue Masutaka、Tsuji Gaku
- Journal Title
  
  International Journal of Molecular Sciences
  
  Volume: 19 Issue: 4 Pages: 1169-1169
- DOI
  10.3390/ijms19041169
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K10213
[Journal Article] The role of the OVOL1-OVOL2 axis in normal and diseased human skin.2018
- Author(s)
  Tsuji G, Ito T, Chiba T, Mitoma C, Nakahara T, Uchi H, Furue M.
- Journal Title
  
  Tsuji G, Ito T, Chiba T, Mitoma C, Nakahara T, Uchi H, Furue M. J Dermatol Sci.
  
  Volume: 90 Issue: 3 Pages: 227-231
- DOI
  10.1016/j.jdermsci.2018.02.005
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K10213
[Journal Article] Therapeutic Agents with AHR Inhibiting and NRF2 Activating Activity for Managing Chloracne2018
- Author(s)
  Furue Masutaka、Fuyuno Yoko、Mitoma Chikage、Uchi Hiroshi、Tsuji Gaku
- Journal Title
  
  Antioxidants
  
  Volume: 7 Issue: 7 Pages: 90-90
- DOI
  10.3390/antiox7070090
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17K10213
[Journal Article] Aryl hydrocarbon receptor activation restores filaggrin expression via OVOL1 in atopic dermatitis.2017
- Author(s)
  Tsuji G, Hashimoto-Hachiya A, Kiyomatsu-Oda M, Takemura M, Ohno F, Ito T, Morino-Koga S, Mitoma C, Nakahara T, Uchi H, Furue M.
- Journal Title
  
  Cell Death Dis.
  
  Volume: 8 Issue: 7 Pages: e2931-e2931
- DOI
  10.1038/cddis.2017.322
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K10213
[Journal Article] Antioxidant Artemisia princeps Extract Enhances the Expression of Filaggrin and Loricrin via the AHR/OVOL1 Pathway.2017
- Author(s)
  Hirano A, Goto M, Mitsui T, Hashimoto-Hachiya A, Tsuji G, Furue M.
- Journal Title
  
  Int J Mol Sci.
  
  Volume: 18 Issue: 9 Pages: 1948-1948
- DOI
  10.3390/ijms18091948
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K10213
[Presentation] Mechanism and future prospects of IL-4 / 13 in the treatment of atopic dermatitis2021
- Author(s)
  Gaku Tsuji
- Organizer
  The 46 th Annual Meeting of The Japanese Society for Investigative Dermatology
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K08653
[Presentation] Activation of aryl hydrocarbon receptor-nuclear factor erythroid 2-related factor 2 axis by epidermal growth factor receptor inhibitors: a possible mechanism for acneiform eruption2015
- Author(s)
  Gaku Tsuji
- Organizer
  ESDR 2015 第45回欧州研究皮膚科学会議
- Place of Presentation
  ロッテルダム、オランダ
- Year and Date
  2015-09-09
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15H06477

1. 古江増隆 (70134583)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results

Tsuji Gaku 辻 学

Research Projects

Research Products

Co-Researchers

Regulatory mechanism of IL-33 in atopic dermatitisPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

アリル炭化水素受容体アゴニストによるアトピー性皮膚炎新規治療薬開発と標的探索

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Roles of the AHR-OVOL1 axis in barrier dysfunction of atopic dermatitisPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Activation of aryl hydrocarbon receptor-nuclear factor erythroid 2-related factor 2 axis by epidermal growth factor receptor inhibitors: a possible mechanism for acneiform eruptionPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] Natural Compounds Tapinarof and Galactomyces Ferment Filtrate Downregulate IL-33 Expression via the AHR/IL-37 Axis in Human Keratinocytes2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] The Antidiabetic Agent Metformin Inhibits IL-23 Production in Murine Bone-Marrow-Derived Dendritic Cells2021

Author(s)

Journal Title

DOI

Data Source

[Journal Article] IL-24 Negatively Regulates Keratinocyte Differentiation Induced by Tapinarof, an Aryl Hydrocarbon Receptor Modulator: Implication in the Treatment of Atopic Dermatitis2020

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Metformin inhibits IL-1β secretion via impairment of NLRP3 inflammasome in keratinocytes: implications for preventing the development of psoriasis2020

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Aryl Hydrocarbon Receptor Activation Downregulates IL-33 Expression in Keratinocytes via Ovo-Like 12020

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Implications of tryptophan photoproduct FICZ in oxidative stress and terminal differentiation of keratinocytes2019

Author(s)

Journal Title

DOI

Data Source

[Journal Article] IL-4 Augments IL-31/IL-31 Receptor Alpha Interaction Leading to Enhanced Ccl 17 and Ccl 22 Production in Dendritic Cells: Implications for Atopic Dermatitis2019

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Tryptophan photo-product FICZ upregulates AHR/MEK/ERK-mediated MMP1 expression: Implications in anti-fibrotic phototherapy2018

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Antioxidative Phytochemicals Accelerate Epidermal Terminal Differentiation via the AHR-OVOL1 Pathway: Implications for Atopic Dermatitis2018

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Glyteer, Soybean Tar, Impairs IL-4/Stat6 Signaling in Murine Bone Marrow-Derived Dendritic Cells: The Basis of Its Therapeutic Effect on Atopic Dermatitis2018

Author(s)

Journal Title

DOI

Data Source

[Journal Article] The role of the OVOL1-OVOL2 axis in normal and diseased human skin.2018

Author(s)

Tsuji Gaku 辻学