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YANOKURA Megumi  矢野倉 恵

Researcher Number 20433732
Other IDs
  • ORCIDhttps://orcid.org/0000-0002-1505-3194
Affiliation (based on the past Project Information) *help 2022 – 2023: 慶應義塾大学, 医学部(信濃町), 特任助教
2016 – 2020: 慶應義塾大学, 医学部(信濃町), 特任助教
2015: 慶應義塾大学, 医学部, 共同研究員
2011 – 2014: 慶應義塾大学, 医学部, 特任助教
2012: 慶應義塾大学, 医学部, 助教
2007 – 2010: Keio University, 医学部, 助教
Review Section/Research Field
Principal Investigator
Obstetrics and gynecology / Basic Section 56040:Obstetrics and gynecology-related
Except Principal Investigator
Obstetrics and gynecology
Keywords
Principal Investigator
子宮体癌 / DNAメチル化 / メチル化 / 着床阻害 / リプログラミング / CHFR / Aurora-A / iPS / 着床機能 / 着床能 … More / COX-2 / カルシウムシグナルパスウェイ / MLH1 / DNA メチル化 / エピジェネティクス異常 / エピミューテーション / CIMP / miR-663a / epimutation / パクリタキセル / エピジェネティクス / miR-34b / in vivoイメージング / タキサン製剤 / 分子イメージング / siRNA / 細胞周期チェックポイント / DDS / アテロコラーゲン … More
Except Principal Investigator
siRNA / エピジェネティック / メチル化 / miRNA / パクリタキセル / タキサン製剤 / miR-34b / CHFR / 子宮体癌 / 婦人科腫瘍学 Less
  • Research Projects

    (7 results)
  • Research Products

    (38 results)
  • Co-Researchers

    (4 People)
  •  Elucidation of implantation inhibition mechanism of endometrial cancer cells using iPS technologyPrincipal Investigator

    • Principal Investigator
      矢野倉 恵
    • Project Period (FY)
      2022 – 2023
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 56040:Obstetrics and gynecology-related
    • Research Institution
      Keio University
  •  Reprogramming study of endometrial cancer cells for restoring fertilityPrincipal Investigator

    • Principal Investigator
      YANOKURA Megumi
    • Project Period (FY)
      2018 – 2020
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 56040:Obstetrics and gynecology-related
    • Research Institution
      Keio University
  •  Genome-wide DNA methylation analysis in endometrial cancerPrincipal Investigator

    • Principal Investigator
      YANOKURA Megumi
    • Project Period (FY)
      2015 – 2017
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Obstetrics and gynecology
    • Research Institution
      Keio University
  •  Application to the development and diagnosis of miRNA therapeutic agent in endometrial cancerPrincipal Investigator

    • Principal Investigator
      YANOKURA MEGUMI
    • Project Period (FY)
      2012 – 2014
    • Research Category
      Grant-in-Aid for Young Scientists (B)
    • Research Field
      Obstetrics and gynecology
    • Research Institution
      Keio University
  •  endometrial cancer therapy using epigenetically regulated small RNA

    • Principal Investigator
      BANNO Kouji
    • Project Period (FY)
      2010 – 2012
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Obstetrics and gynecology
    • Research Institution
      Keio University
  •  Antitumor effect of siRNA on endometrial cancerPrincipal Investigator

    • Principal Investigator
      YANOKURA Megumi
    • Project Period (FY)
      2009 – 2011
    • Research Category
      Grant-in-Aid for Young Scientists (B)
    • Research Field
      Obstetrics and gynecology
    • Research Institution
      Keio University
  •  Combinational antitumor effect of siRNA against M phase checkpoint gene and paclitaxel on growth of human endometrial cancerPrincipal Investigator

    • Principal Investigator
      YANOKURA Megumi
    • Project Period (FY)
      2007 – 2008
    • Research Category
      Grant-in-Aid for Young Scientists (B)
    • Research Field
      Obstetrics and gynecology
    • Research Institution
      Keio University

All 2021 2019 2017 2016 2015 2014 2013 2012 2010 2009 2008 2007 Other

All Journal Article Presentation

  • [Journal Article] Genome-wide DNA methylation sequencing revealed that miR-663a is a novel epimutation candidate in CIMP- high endometrial cancer.2017

    • Author(s)
      Megumi Yanokura, Kouji Banno, Masataka Adachi, Daisuke Aoki, Kuniya Abe
    • Journal Title

      International Journal of Oncology

      Volume: - Issue: 6 Pages: 1934-1946

    • DOI

      10.3892/ijo.2017.3966

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PUBLICLY-16H01225, KAKENHI-PROJECT-26250025, KAKENHI-PROJECT-16K14644, KAKENHI-PROJECT-16K11154, KAKENHI-PROJECT-15H01749, KAKENHI-PROJECT-15K10727
  • [Journal Article] MicroRNA in cervical cancer: OncomiRs and tumor suppressor miRs in diagnosis and treatment.2014

    • Author(s)
      Banno K, Iida M, Yanokura M, Kisu I, Iwata T, Tominaga E, Tanaka K, Aoki D.
    • Journal Title

      ScientificWorldJournal

      Volume: 2 Pages: 178075-178075

    • DOI

      10.1155/2014/178075

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-24791718
  • [Journal Article] Application of microRNA in diagnosis and treatment of ovarian cancer.2014

    • Author(s)
      Banno K, Yanokura M, Iida M, Adachi M, Nakamura K, Nogami Y, Umene K, Masuda K, Kisu I, Nomura H, Kataoka F, Tominaga E, Aoki D.
    • Journal Title

      Biomed Res Int.

      Volume: - Pages: 1-6

    • DOI

      10.1155/2014/232817

    • Peer Reviewed / Acknowledgement Compliant / Open Access
    • Data Source
      KAKENHI-PROJECT-24791718
  • [Journal Article] Carcinogenic mechanisms of endometrial cancer: involvement of genetics and epigenetics.2014

    • Author(s)
      Banno K, Yanokura M, Iida M, Masuda K, Aoki D.
    • Journal Title

      J Obstet Gynaecol Res.

      Volume: 40 Issue: 8 Pages: 1957-1967

    • DOI

      10.1111/jog.12442

    • Peer Reviewed / Acknowledgement Compliant / Open Access
    • Data Source
      KAKENHI-PROJECT-24791718
  • [Journal Article] MicroRNAs in endometrial cancer.2013

    • Author(s)
      Banno K, Yanokura M, Kisu I, Yamagami W, Susumu N, Aoki D
    • Journal Title

      International journal of clinical oncology

      Volume: 18 Issue: 2 Pages: 186-192

    • DOI

      10.1007/s10147-013-0526-9

    • NAID

      10031176254

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-22390313, KAKENHI-PROJECT-22591866, KAKENHI-PROJECT-22591867, KAKENHI-PROJECT-24791718, KAKENHI-PROJECT-25462608
  • [Journal Article] Epigenetics and genetics in endometrial cancer : new carcinogenic mechanisms and relationship with clinical practice2012

    • Author(s)
      Banno K, Kisu I, Yanokura M, Masuda K, Ueki A, Kobayashi Y, Susumu N, Aoki D
    • Journal Title

      Epigenomics

      Volume: 4 Pages: 147-162

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21791573
  • [Journal Article] Epigenetics and genetics in endometrial cancer : new carcinogenic mechanisms and relationship with clinical practice2012

    • Author(s)
      Banno K, Kisu I, Yanokura M, Masuda K, Ueki A, Kobayashi Y, Susumu N, Aoki D
    • Journal Title

      Epigenomics

      Volume: 4 Pages: 147-162

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-22591866
  • [Journal Article] Endometrial Cancer and Hypermethylation: Regulation of DNA and MicroRNA by Epigenetics.2012

    • Author(s)
      Banno K, Kisu I, Yanokura M, Masuda K, Kobayashi Y, Ueki A, Tsuji K, Yamagami W, Nomura H, Susumu N, Aoki D
    • Journal Title

      Biochemistry Research International

      Volume: 2012 Pages: 738274-738274

    • DOI

      10.1155/2012/738274

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-22390313, KAKENHI-PROJECT-22591866, KAKENHI-PROJECT-22591867
  • [Journal Article] Endometrial Cancer and Hypermethylation : Regulation of DNA a nd microRNA by Epigenetics2012

    • Author(s)
      Banno K, Kisu I, Yanokura M, Masuda K, Kobayashi Y, Ueki A, Tsuji K, Yamagami W, Nomura H, Susumu N, Aoki D
    • Journal Title

      Biochemistry Research International

      Volume: (印刷中)

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21791573
  • [Journal Article] Epigenetics and genetics in endometrial cancer: new carcinogenic mechanisms and relationship with clinical practice.2012

    • Author(s)
      Banno K, Kisu I, Yanokura M, Masuda K, Ueki A, Kobayashi Y, Susumu N, Aoki D
    • Journal Title

      Epigenomics

      Volume: 4 Issue: 2 Pages: 147-162

    • DOI

      10.2217/epi.12.13

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-22390313, KAKENHI-PROJECT-22591866, KAKENHI-PROJECT-22591867
  • [Journal Article] Biomarkers in endometrial cancer: Possible clinical applications (Review).2012

    • Author(s)
      Banno K, Kisu I, Yanokura M, Tsuji K, Masuda K, Ueki A, Kobayashi Y, Yamagami W, Nomura H, Tominaga E, Susumu N, Aoki D.
    • Journal Title

      Oncol Lett.

      Volume: 3(6) Pages: 1175-1180

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-24791718
  • [Journal Article] MicroRNA and endometrial cancer: Roles of small RNAs in human tumors and clinical applications (Review)2010

    • Author(s)
      Yanokura M, Banno K, Kobayashi Y, Kisu I, Ueki A, Ono A, Masuda K, Nomura H, Hirasawa A, Susumu N, Aoki D
    • Journal Title

      Oncol Lett

      Volume: 1(6) Pages: 935-940

    • URL

      http://www.ncbi.nlm.nih.gov/pubmed/22870090

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-22591866
  • [Journal Article] Epigenetic DNA hypermethylation : clinical applications in endometrial cancer(Review)2009

    • Author(s)
      Muraki Y, Banno K, Yanokura Mm, et al(6).
    • Journal Title

      Oncol Rep. 22

      Pages: 967-972

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21791573
  • [Journal Article] Endometrial cancer as a familial tumor : pathology and molecular carcin ogenesis(review).2009

    • Author(s)
      Banno K, Yanokura M, Kobayashi Y, et al(5).
    • Journal Title

      Curr Genomics. 10

      Pages: 127-132

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21791573
  • [Journal Article] Analysis of a correlation between the BRAF V600E mutation and abnormal DNA mismatch repair in patients with sporadic endometrial cancer2009

    • Author(s)
      Kawaguchi M, Yanokura M, Banno K, et al(7).
    • Journal Title

      Int J Oncol. 34

      Pages: 1541-1547

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21791573
  • [Journal Article] hypermethylation of cancer-related genes in carcinogenesis of endometrial cancer2008

    • Author(s)
      Banno K, Yanokura M, Susumu N, Ao ki D. Epigenetic DNA
    • Journal Title

      In: Maruo T, Mardon H, Stewart C, eds. Translatrional Research in Uterine Biology, Amsterdam : ELSEVIER

      Pages: 191-200

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19791163
  • [Journal Article] Use of the collagen gel droplet embedded drug sensitivity test to determine drug sensitivity against ovarian mature cystic teratoma with malignant transformation to adenocarcinoma ; A case report2007

    • Author(s)
      Yamagami W, Banno K, Kawaguchi M, Yanokura M, Kuwabara Y, Hirao N, Susumu N, Tsukazaki K, Aoki D
    • Journal Title

      Chemotherapy 53

      Pages: 137-141

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19791163
  • [Journal Article] Relationship of aberrant DNA hypermethylation of CHFR with sensitivity to taxanes in endometrial cancer2007

    • Author(s)
      Yanokura M*, Banno K*, Kawaguchi M, Hirao N, Hirasawa A, Susumu N, Tsukazaki K, Aoki D
    • Journal Title

      Oncology Reports 17

      Pages: 41-48

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19791163
  • [Journal Article] Epigenetic inactivation of the CHFR gene in cervical cancer contributes to sensitivity to taxanes2007

    • Author(s)
      Banno K*, Yanokura M*, Kawaguchi M, Kuwabara Y, Akiyoshi J, Kobayashi Y, Iwata T, Hirasawa A, Fujii T, Susumu N, Tsukazaki K, Aoki D
    • Journal Title

      Int J of Oncol 2007 31

      Pages: 713-720

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19791163
  • [Journal Article] Biomarkers in Endometrial Cancer : Possible clinical applications

    • Author(s)
      Banno K, Kisu I, Yanokura M, Tsuji K, Masuda K, Ueki A, Kobayashi Y, Yamagami W, Nomura H, Tominaga E, Susumu N, Aoki D
    • Journal Title

      Oncology Letters

      Volume: (Review)(印刷中)

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-22591866
  • [Journal Article] Endometrial Cancer and Hypermethylation : Regulation of DNA and microRNA by Epigenetics

    • Author(s)
      Banno K, Kisu I, Yanokura M, Masuda K, Kobayashi Y, Ueki A, Tsuji K, Yamagami W, Nomura H, Susumu N, Aoki D
    • Journal Title

      Biochemistry Research International

      Volume: (印刷中)

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-22591866
  • [Journal Article] Endometrial Cancer and Hypermethylation : Regulation of DNA and microRNA by Epigenetics

    • Author(s)
      Banno K, Kisu I, Yanokura M, Masuda K, Kobayashi Y, Ueki A, Tsuji K, Yamagami W, Nomura H, Susumu N, Aoki D
    • Journal Title

      Biochemistry Research International

      Volume: (印刷中)

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21791573
  • [Journal Article] Biomarkers in Endometrial Cancer : Possible clinical applications (Review)

    • Author(s)
      Banno K, Kisu I, Yanokura M, Tsuji K, Masuda K, Ueki A, Kobayashi Y, Yamagami W, Nomura H, Tominaga E, Susumu N, Aoki D
    • Journal Title

      Oncology Letters

      Volume: (印刷中)

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21791573
  • [Presentation] リプログラミングされた子宮体癌由来培養細胞を用いた内膜着床阻止メカニズムの探索2021

    • Author(s)
      矢野倉恵, 阪埜浩司, 的場優介, 小林佑介, 冨永英一郎, 田中守, 青木大輔
    • Organizer
      第73回日本産科婦人科学会
    • Data Source
      KAKENHI-PROJECT-18K09272
  • [Presentation] ヒト子宮体癌由来培養細胞を用いたReprogrammed-Cancer cellの作成2019

    • Author(s)
      矢野倉恵、阪埜浩司、的場優介、小林祐介、冨永英一郎、田中守、青木大輔
    • Organizer
      第71回日本産科婦人科学会学術講演会
    • Data Source
      KAKENHI-PROJECT-18K09272
  • [Presentation] CIMP-H子宮体癌患者の末梢血を利用したTargeted bisulfite sequencing2016

    • Author(s)
      矢野倉 恵
    • Organizer
      日本癌学会
    • Place of Presentation
      パシフィコ横浜(神奈川県横浜市)
    • Year and Date
      2016-10-06
    • Data Source
      KAKENHI-PROJECT-15K10727
  • [Presentation] ジエノゲストとメトホルミンの併用はメチル化状態を変化させ子宮体癌の増殖を抑制する2015

    • Author(s)
      矢野倉 恵
    • Organizer
      第36回日本エンドメトリオーシス学会学術講演会
    • Place of Presentation
      ハイアットリージェンシー(東京都新宿区)
    • Year and Date
      2015-01-25
    • Data Source
      KAKENHI-PROJECT-24791718
  • [Presentation] ジェノゲストおよびメトホルミンの併用による子宮内膜癌細胞に対する増殖抑制効果の基礎的検討2014

    • Author(s)
      矢野倉 恵
    • Organizer
      第66回日本産科婦人科学会学術講演会
    • Place of Presentation
      東京国際フォーラム(東京都千代田区)
    • Year and Date
      2014-04-20
    • Data Source
      KAKENHI-PROJECT-24791718
  • [Presentation] メトホルミンとディナゲスト併用による新たな子宮体癌治療の可能性2014

    • Author(s)
      矢野倉 恵
    • Organizer
      第73回日本癌学会学術総会
    • Place of Presentation
      パシフィコ横浜(神奈川県横浜市)
    • Year and Date
      2014-09-25
    • Data Source
      KAKENHI-PROJECT-24791718
  • [Presentation] 子宮体癌においてエピジェネティックに制御される miR-34b の同定とその癌抑制効果2012

    • Author(s)
      矢野倉 恵
    • Organizer
      第64回日本産科婦人科学会学術講演会
    • Place of Presentation
      神戸
    • Year and Date
      2012-04-13
    • Data Source
      KAKENHI-PROJECT-22591866
  • [Presentation] 子宮体癌に対する miR-34b とパクリタキセル併用による抗腫瘍効果の検討2012

    • Author(s)
      矢野倉 恵
    • Organizer
      第71回日本癌学会学術総会
    • Place of Presentation
      札幌
    • Year and Date
      2012-09-21
    • Data Source
      KAKENHI-PROJECT-22591866
  • [Presentation] 子宮体癌においてエピジェネティックに制御されるmiR-34bの同定とその癌抑制効果2012

    • Author(s)
      矢野倉恵
    • Organizer
      日本産科婦人科学会
    • Place of Presentation
      神戸国際展示場(神戸)(発表確定)
    • Year and Date
      2012-04-13
    • Data Source
      KAKENHI-PROJECT-22591866
  • [Presentation] 子宮頸癌におけるM期チェックポイント遺伝子CHFRの異常メチル化の分子指標としての可能性2007

    • Author(s)
      矢野倉恵
    • Organizer
      第59回日本産科婦人科学会学術集会
    • Place of Presentation
      京都
    • Year and Date
      2007-04-16
    • Data Source
      KAKENHI-PROJECT-19791163
  • [Presentation] Expression of a mitotic kinase, Aurora-A2007

    • Author(s)
      矢野倉恵
    • Organizer
      affects taxane sensitivity in endometrial cancer, 20th AOCOG
    • Place of Presentation
      東京
    • Year and Date
      2007-09-24
    • Data Source
      KAKENHI-PROJECT-19791163
  • [Presentation] 子宮体癌においてエピジェネティックに制御されるmiR-34bの同定とその癌抑制効果

    • Author(s)
      矢野倉 恵、阪埜 浩司、増田 健太、木須 伊織、植木 有紗、辻 浩介、小林 佑介、 山上 亘、進 伸幸、青木 大輔、吉村 泰典
    • Organizer
      第64回日本産科婦人科学会学術講演会
    • Place of Presentation
      神戸国際展示場・神戸
    • Data Source
      KAKENHI-PROJECT-24791718
  • [Presentation] 子宮体癌に対するmiR-34bとパクリタキセル併用による抗腫瘍効果の検討

    • Author(s)
      矢野倉 恵、阪埜浩司、増田健太、木須伊織、植木有紗、小林佑介、山上 亘、進 伸幸、 青木大輔
    • Organizer
      第71回日本癌学会学術総会
    • Place of Presentation
      ホテルロイトン札幌・札幌
    • Data Source
      KAKENHI-PROJECT-24791718
  • [Presentation] 子宮体癌細胞に対するmiR-34bと抗癌剤の併用による抗腫瘍効果の検討

    • Author(s)
      矢野倉 恵
    • Organizer
      第65回日本産科婦人科学会学術講演会
    • Place of Presentation
      ロイトン札幌(北海道)
    • Data Source
      KAKENHI-PROJECT-24791718
  • [Presentation] 子宮体癌におけるmiR-34bの分子標的薬としての可能性

    • Author(s)
      矢野倉 恵
    • Organizer
      第12回日本婦人科がん分子標的研究会学術集会
    • Place of Presentation
      東大寺総合文化センター(奈良)
    • Data Source
      KAKENHI-PROJECT-24791718
  • 1.  BANNO Kouji (70265875)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 7 results
  • 2.  NOMURA Hiyoyuki
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 3.  阿部 訓也
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 4.  青木 大輔
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 3 results

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