Ohashi Shinya 大橋真也

… Alternative Names

OHASHI Sinya 大橋真也

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Researcher Number	20435556
Other IDs	https://orcid.org/0000-0003-1776-4309
Affiliation (Current)	2025: 京都大学, 医学研究科, 特定准教授
Affiliation (based on the past Project Information) *help	2020 – 2024: 京都大学, 医学研究科, 特定准教授 2016 – 2019: 京都大学, 医学研究科, 助教 2013 – 2015: 京都大学, 医学(系)研究科(研究院), 助教 2007: Tazuke Kofukai Medical Research Institute, 医学研究所・第3研究部, 研究員 2006: (財)田附興風会, 医学研究所・第3研究部, 研究員 2006: The Tazuke Kofukai, Medical Research Institute 3rd Division, Researcher, 医学研究所第3研究部, 研究員
Review Section/Research Field	Principal Investigator Basic Section 53010:Gastroenterology-related / Gastroenterology / Digestive surgery Except Principal Investigator Basic Section 53010:Gastroenterology-related / Medium-sized Section 50:Oncology and related fields / Basic Section 50020:Tumor diagnostics and therapeutics-related / Digestive surgery
Keywords	Principal Investigator 食道扁平上皮癌 / 合成致死 / トリフルリジン / DNA修復応答 / 食道癌 / Wee1阻害 / 食度扁平上皮癌 / TAS-102 / トリフルリジン（FTD) / Synthetic lethality … More / DNA障害 / DNA修復 / DNA傷害 / 放射線治療 / CHK1阻害剤 / 放射線感受性 / CHK1シグナル阻害 / 発がん予防 / 食道 / 癌 / ALDH2活性増強 / アルコール / 食道がん / DNAアダクト / ALDH2活性 / ヒト変異型ALDH2ノックインマウス / Alda-1 / ALDH2活性化 / ALDH2遺伝子多型 / ALDH2 / 発癌 / アセトアルデヒド / 抗がん剤耐性 / EGFR阻害 / 細胞分化 / 治療抵抗性 / 間葉系癌細胞 / 上皮系癌細胞 / EGFRシグナル阻害 / 分化誘導 / EGFR阻害剤 / 人工的潰瘍 / 内視鏡的粘膜切除 / トレフォイルファクター / 消化管粘膜修復因子 / 消化管の創傷治癒 … More Except Principal Investigator 遺伝子変異 / ALDH2活性剤 / 食道発がんモデル / 食道扁平上皮癌 / アルコール / 遺伝子多型 / 食道がん / アルコール発がん / 重鎖・軽鎖組合せ / 食道癌 / 抗体配列進化 / 抗がん抗体 / 抗体レパトア解析 / 抗体スクリーニング / 癌抗体 / 抗体親和性成熟 / 抗体配列進化追跡法 / データベース / クリニカルシークエンス / がんゲノム / actionability / がんクリニカルシークエンス / アファチニブ / 大腸がん / APC / HER2 / VUS / artificial gastric ulcer / Endoscopic mucosal resection / Intestinal trefoil factor / Trefoil factor family / promoter of epithelial repair / Epithelial wound healing / 人工潰瘍 / 消化管の創傷治癒 / 人工的潰瘍 / 内視鏡的粘膜切除(EMR) / ITF / トレフォイルファクターファミリー / 消化管粘膜修復因子 / 消化器の創傷治癒 Less

アルコール長期曝露による正常食道上皮に生じる変異負荷や微小環境変化の解明
- Principal Investigator
  
  横山顕礼
- Project Period (FY)
  2024 – 2026
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 53010:Gastroenterology-related
- Research Institution
  Kyoto University
アルコールによる食道発がんメカニズムの本態解明と予防薬開発に関する研究
- Principal Investigator
  
  武藤学
- Project Period (FY)
  2024 – 2026
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 53010:Gastroenterology-related
- Research Institution
  Kyoto University
Establishment of a novel therapeutic strategy for esophageal squamous cell carcinoma with the combination of trifluridine and Wee1 inhibitorPrincipal Investigator
- Principal Investigator
  
  大橋真也
- Project Period (FY)
  2022 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 53010:Gastroenterology-related
- Research Institution
  Kyoto University
Establishment of innovative development scheme of anti-cancer antibody
- Principal Investigator
  
  Matsuda Tomonari
- Project Period (FY)
  2020 – 2022
- Research Category
  
  Grant-in-Aid for Challenging Research (Pioneering)
- Review Section
  
  Medium-sized Section 50:Oncology and related fields
- Research Institution
  Kyoto University
Synthetic lethality with FTD and CHK1 inhibitor for esophageal squamous cell carcinomaPrincipal Investigator
- Principal Investigator
  
  OHASHI SHINYA
- Project Period (FY)
  2019 – 2021
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 53010:Gastroenterology-related
- Research Institution
  Kyoto University
Research on Biological and Clinical Significance of VUS in Cancer Clinical Sequencing
- Principal Investigator
  
  Muto Manabu
- Project Period (FY)
  2018 – 2020
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 50020:Tumor diagnostics and therapeutics-related
- Research Institution
  Kyoto University
Preventive effects of ALDH2 activator on esophageal carcinogenesisPrincipal Investigator
- Principal Investigator
  
  Ohashi Shinya
- Project Period (FY)
  2016 – 2018
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Gastroenterology
- Research Institution
  Kyoto University
Anti-tumor effects of EGFR inhibitors via cell differentiation on esophageal cancer cellsPrincipal Investigator
- Principal Investigator
  
  Ohashi Shinya
- Project Period (FY)
  2013 – 2015
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Gastroenterology
- Research Institution
  Kyoto University
内視鏡的粘膜切除後消化管粘膜欠損に対するITFの臨床応用Principal Investigator
- Principal Investigator
  
  大橋真也
- Project Period (FY)
  2007
- Research Category
  
  Grant-in-Aid for Young Scientists (Start-up)
- Research Field
  
  Digestive surgery
- Research Institution
  Tazuke Kofukai Medical Research Institute
Investigation of the possibility of Trefoil Factor Family as a therapeutics for post-EMR (endoscopic mucosal resection) gastric ulcer
- Principal Investigator
  
  KANAI Michiyuki
- Project Period (FY)
  2004 – 2006
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Digestive surgery
- Research Institution
  The Tazuke Kofukai

All 2023 2022 2021 2020 2019 2018 2017 2016 2015 2014 2013 2006 Other

All Journal Article Presentation

[Journal Article] Visceral fat obesity is the key risk factor for the development of reflux erosive esophagitis in 40-69-years subjects2021
- Author(s)
  Shinya Ohashi, Takahisa Maruno, Keita Fukuyama, Osamu Kikuchi, Tomohiko Sunami, Ｙuki Ｋondo, Ｓeiichiro Ｉmai, Ｍatsushima Ａki, Ｋimiyo Ｓuzuki, Ｆumika Ｕsui, Ｍasahiro Ｙakami, Ａtsushi Yamada, Hiroyoshi Isoda, Shigemi Matsumoto, Hiroshi Seno, Manabu Muto, Mayumi Inoue
- Journal Title
  
  Esophagus
  
  Volume: 18 Issue: 4 Pages: 889-899
- DOI
  10.1007/s10388-021-00859-5
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K08369, KAKENHI-PROJECT-20H03659
[Journal Article] Association of local complete response with prognosis after salvage photodynamic therapy for esophageal squamous cell carcinoma.2021
- Author(s)
  Yusuke Amanuma, Takahiro Horimatsu, Shinya Ohashi, Masashi Tamaoki, Manabu Muto.
- Journal Title
  
  Dig Endosc.
  
  Volume: 33 Issue: 3 Pages: 355-363
- DOI
  10.1111/den.13730
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18H02692
[Journal Article] Comprehensive genomic profiling for patients with chemotherapy-naive advanced cancer.2020
- Author(s)
  Kondo T, Matsubara J , Pham Nguyen Quy, Fukuyama K, Nomura M, Funakoshi T, Doi K , Sakamori Y, Yoshioka M , Yokoyama A , Tamaoki M, Kou T , Hirohashi K ,Yamada A, Yamamoto Y , Minamiguchi S , Nishigaki M, Yamada T, Kanai M , Matsumoto S , Muto M.
- Journal Title
  
  Cancer Sci.
  
  Volume: 112 Issue: 1 Pages: 296-304
- DOI
  10.1111/cas.14674
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18H02692, KAKENHI-PROJECT-20J23386
[Journal Article] Experimental model for the irradiation-mediated abscopal effect and factors influencing this effect.2020
- Author(s)
  Kiichiro Baba, Motoo Nomura, Shinya Ohashi, Takuya Hiratsuka, Yukie Nakai, Tomoki Saito, Yuki Kondo, Keita Fukuyama, Osamu Kikuchi, Atsushi Yamada, Junichi Matsubara, Kenshiro Hirohashi, Yosuke Mitani, Ayaka Mizumoto, Manabu Muto.
- Journal Title
  
  Am J Cancer Res.
  
  Volume: 10 Pages: 440-453
- NAID
  120006890704
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18H02692
[Journal Article] Cancer of unknown primary with EGFR mutation successfully treated with targeted therapy directed by clinical next-generation sequeincing: a case report2020
- Author(s)
  Mitani Y, Kanai M, Kou T, Kataoka S, Doi K, Matsubara J, Ohashi S, Matsumoto S, Muto M.
- Journal Title
  
  BMC Cancer
  
  Volume: 20 Issue: 1 Pages: 1177-1177
- DOI
  10.1186/s12885-020-07640-4
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K08369, KAKENHI-PROJECT-18H02692
[Journal Article] E487K-induced disorder in functionally relevant dynamics of mitochondrial aldehyde dehydrogenase 22020
- Author(s)
  Matsumoto S, Araki M, Isaka Y, Ono F, Hirohashi K, Ohashi S, Muto M, Okuno Y
- Journal Title
  
  Biophysical Journal
  
  Volume: 119 Issue: 3 Pages: 628-637
- DOI
  10.1016/j.bpj.2020.07.002
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K08369, KAKENHI-PROJECT-17K15106, KAKENHI-PROJECT-18H02692
[Journal Article] Experimental model for the irradiation-mediated abscopal effect and factors influencing this effect2020
- Author(s)
  Baba K, Nomura M, Ohashi S, Hiratsuka T, Nakai Y, Saito T, Kondo Y, Fukuyama K, Kikuchi O, Yamada A, Matsubara J, Hirohashi K, Mitani Y, Mizumoto A, Muto M
- Journal Title
  
  American Journal of Cancer Research
  
  Volume: 10 Pages: 440-453
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K08369
[Journal Article] Autophagy migrates ethanol-induced mitochondrial dysfunction and oxidative stress in esophageal keratinocytes2020
- Author(s)
  Chandranouleeswaran PM, Guha M, Shimonosono M, Whealan KA, Ruthel G, Mukherjee S, Gonzalez MV, Garifallou J, Amesaros C, Blair IA, Pellegrino R, Noguchi E, Hakonarson H, Baur JA, Engel N, Maekawa H, Sachdeva UM, Ohashi S, Klein-Szanto A, Nakagawa H,
- Journal Title
  
  PLOS One
  
  Volume: 15 Issue: 9 Pages: e0239625-e0239625
- DOI
  10.1371/journal.pone.0239625
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K08369
[Journal Article] Synthetic Lethality with Trifluridine/Tipiracil and Checkpoint Kinase 1 Inhibitor for Esophageal Squamous Cell Carcinoma.2020
- Author(s)
  Shinya Ohashi, Osamu Kikuchi, Yukie Nakai, Tomomi Ida, Tomoki Saito, yuki Kondo, Yoshihiro Yamamoto, Yosuke Mitani, Trang H. Nguyen Vu, Keita Fukuyama, Hiroshi Tsukihara, Norihiko Suzuki, Manabu Muto.
- Journal Title
  
  Mol Cancer Ther.
  
  Volume: 19 Issue: 6 Pages: 1363-1372
- DOI
  10.1158/1535-7163.mct-19-0918
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18H02692
[Journal Article] Combination treatment with highly bioavailable curcumin and NQO1 inhibitor exhibits potent antitumor effects on esophageal squamous cell carcinoma.2019
- Author(s)
  Mizumoto A, Ohashi S, Kamada M, Saito T, Nakai Y, Baba K, Hirohashi K, Mitani Y, Kikuchi O, Matsubara J, Yamada A, Takahashi T, Lee H, Okuno Y, Kanai M, Muto M.
- Journal Title
  
  Journal of Gastroenterology
  
  Volume: ― Issue: 8 Pages: 687-698
- DOI
  10.1007/s00535-019-01549-x
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-16K09281, KAKENHI-PROJECT-19K08369
[Journal Article] Age-related remodelling of oesophageal epithelia by mutated cancer drivers.2019
- Author(s)
  Yokoyama A, Ogawa S., et al.
- Journal Title
  
  Nature
  
  Volume: 565 Issue: 7739 Pages: 312-317
- DOI
  10.1038/s41586-018-0811-x
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PLANNED-15H05909, KAKENHI-PLANNED-15H05912, KAKENHI-PLANNED-26115009, KAKENHI-PROJECT-16H05338, KAKENHI-PROJECT-18H02692, KAKENHI-PROJECT-17K19595, KAKENHI-PROJECT-17K19608, KAKENHI-PROJECT-15H05791
[Journal Article] Patient-derived tumor models of esophageal cancer2019
- Author(s)
  Tomoki Saito, Shinya Ohashi, Ayaka Mizumoto, Manabu Muto
- Journal Title
  
  Enzymes
  
  Volume: 46 Pages: 97-111
- DOI
  10.1016/bs.enz.2019.10.003
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19K08369
[Journal Article] Protective effects of Alda-1, an ALDH2 activator, on alcohol-derived DNA damage in the esophagus of human ALDH2*2(Glu504Lys) knock-in mice2019
- Author(s)
  Kenshiro Hirohashi, Shinya Ohashi, Yusuke Amanuma, Yukie Nakai, Tomomi Ida, Kiichiro Baba, Yosuke Mitani, Ayaka Mizumoto, Yoshihiro Yamamoto, Osamu Kikuchi, Junichi Matsubara, Atsushi Yamada, Shin'ichi Miyamoto, Hiroshi Seno, Tomonori Matsuda, Manabu Muto
- Journal Title
  
  Carcinogenesis
  
  Volume: ― Issue: 2 Pages: 194-202
- DOI
  10.1093/carcin/bgz091
- NAID
  120006649578
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K08369, KAKENHI-PROJECT-18H02692
[Journal Article] 気管食道科領域におけるアルコール発がん　―広域発がん現象―2018
- Author(s)
  玉置将司、大橋真也、武藤学
- Journal Title
  
  日本食道気管学会会報
  
  Volume: 69 Pages: 275-281
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-16K09281
[Journal Article] Molecular mechanisms of acetaldehyde-mediated carcinogenesis in squamous epithelium.2017
- Author(s)
  Mizumoto A, Ohashi S, Hirohashi K, Amanuma Y, Matsuda T, Muto M.
- Journal Title
  
  International Journal of Molecular Sciences.
  
  Volume: 18 Issue: 9 Pages: 1943-1943
- DOI
  10.3390/ijms18091943
- NAID
  120006497359
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-16K09281
[Journal Article] アルコール代謝と頭頸部癌学―広域発がん現象―2017
- Author(s)
  大橋真也、武藤学
- Journal Title
  
  日本臨床増刊号　頭頸部癌学
  
  Volume: 75 Pages: 96-101
- Data Source
  KAKENHI-PROJECT-16K09281
[Journal Article] Distinct effects of EGFR inhibitors on epithelial- and mesenchymal-like esophageal squamous cell carcinoma cells.2017
- Author(s)
  Yoshioka M, Ohashi S, Ida T, Nakai Y, Kikuchi O, Amanuma Y, Matsubara J, Yamada A, Miyamoto S, Natsuizaka M, Nakagawa H, Chiba T, Seno H, Muto M.
- Journal Title
  
  J Exp Clin Cancer Res.
  
  Volume: 36 Issue: 1 Pages: 101-101
- DOI
  10.1186/s13046-017-0572-7
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-16K09281, KAKENHI-PROJECT-15K08943
[Journal Article] Establishment of a quick and highly available accurate breath test for ALDH2 genotyping.2017
- Author(s)
  Aoyama I, Ohashi S, Amanuma Y, Hirohashi K, Mizumoto A, Funakoshi M, Tsurumaki M, Nakai Y, Tanaka K, Hanada M, Uesaka A, Chiba T, Muto M.
- Journal Title
  
  Clin Transl Gastroenterol.
  
  Volume: 8 Issue: 6 Pages: e96-e96
- DOI
  10.1038/ctg.2017.24
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-16K09281
[Journal Article] ALDH2 modulates autophagy flux to regulate acetaldehyde-mediated toxicity thresholds.2016
- Author(s)
  Tanaka K, Whelan KA, Chandramouleeswaran PM, Kagawa S, Rustgi SL, Noguchi C, Guha M, Srinvasan S, Amanuma Y, Ohashi S, Muto M, Klein-Szanto AJ, Noguchi E, Avadhani NG, Nakagawa H.
- Journal Title
  
  Am J Cancer Res.
  
  Volume: 6 Pages: 781-796
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-16K09281
[Journal Article] Carcinogenesis and genetic alterations in squamous epithelium of the esophagus2016
- Author(s)
  大橋真也、武藤学
- Journal Title
  
  Nippon Shokakibyo Gakkai Zasshi
  
  Volume: 113 Issue: 11 Pages: 1857-1867
- DOI
  10.11405/nisshoshi.113.1857
- NAID
  130005277820
- ISSN
  0446-6586, 1349-7693
- Language
  Japanese
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16K09281
[Journal Article] Novel EGFR-targeted strategy with hybrid peptide against oesophageal squamous cell carcinoma.2016
- Author(s)
  Kikuchi, O, Ohashi, S, Horibe, T, Kohno, M, Nakai, Y, Miyamoto, S, Chiba, T, Muto, M and Kawakami, K
- Journal Title
  
  Scientific reports
  
  Volume: 6 Issue: 1 Pages: 22452-22452
- DOI
  10.1038/srep22452
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-14J02741, KAKENHI-PROJECT-25460926, KAKENHI-PROJECT-26290052, KAKENHI-PROJECT-26460968, KAKENHI-PROJECT-16K09281
[Journal Article] Alcohol consumption and multiple dysplastic lesions increase risk of squamous cell carcinoma in the esophagus, head, and neck.2016
- Author(s)
  Katada C, Yokoyama T, Yano T, Kaneko K, Oda I, Shimizu Y, Doyama H, Koike T, Takizawa K, Hirao M, Okada H, Yoshii T, Konishi K, Yamanouchi T, Tsuda T, Omori T, Kobayashi N, Shimoda T, Ochiai A, Amanuma Y, Ohashi S, Matsuda T, Ishikawa H, Yokoyama A, Muto M.
- Journal Title
  
  Gastroenterology
  
  Volume: 151 Issue: 5 Pages: 860-869
- DOI
  10.1053/j.gastro.2016.07.040
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-16K09281
[Journal Article] ALDH2 modulates autophagy flux to regulate acetaldehyde-mediated toxicity thresfolds.2016
- Author(s)
  Tanaka K, Whelan KA, Chandramouleeswaran PM, Kagawa S, Rustgi SL, Noguchi C, Guha M, Srinvasan S, Amanuma Y, Ohashi S, Muto M, Klein-Szanto AJ, Noguchi E, Avadhani NG, Nakagawa H.
- Journal Title
  
  Am J Cancer Res
  
  Volume: in press
- Peer Reviewed / Acknowledgement Compliant / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-25460926
[Journal Article] PDTのメカニズム・・・とくに食道癌細胞株におけるアポトーシスについて2015
- Author(s)
  大橋真也、武藤学
- Journal Title
  
  G.I.Research
  
  Volume: 23 Pages: 297-302
- Data Source
  KAKENHI-PROJECT-25460926
[Journal Article] Novel 5-fluorouracil-resistant human esophageal squamous cell carcinoma cells with dihydropyrimidine dehydrogenase overexpression.2015
- Author(s)
  Kikuchi O, Ohashi S, Nakai Y, Nakagawa S, Matsuoka K, Kobunai T, Takechi T, Amanuma Y, Yoshioka M, Ida T, Yamamoto Y, Okuno Y, Miyamoto S, Nakagawa H, Matsubara K, Chiba T, Muto M.
- Journal Title
  
  Am J Cancer Res
  
  Volume: 5 Pages: 2431-2440
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-25460926
[Journal Article] Protective role of ALDH2 against acetaldehyde-derived DNA damage in oesophageal squamous epithelium2015
- Author(s)
  Amanuma Y, Ohashi S, Itatani Y, Tsurumaki M, Matsuda S, Kikuchi1 O, Naka Y, Miyamoto S, Oyama T, Kawamoto T, Whelan KA, Nakagawa H, Chiba T, Matsuda T, Muto M
- Journal Title
  
  Scientific Reports
  
  Volume: 5 Issue: 1 Pages: 14142-14142
- DOI
  10.1038/srep14142
- NAID
  120005678158
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-25340064, KAKENHI-PROJECT-26460968, KAKENHI-PROJECT-23221006, KAKENHI-PROJECT-25460926, KAKENHI-PROJECT-25462187
[Journal Article] Recent Advances from Basic and Clinical Studies of Esophageal Squamous Cell Carcinoma.2015
- Author(s)
  Ohashi S, Miyamoto S, Kikuchi O, Goto T, Amanuma Y, Muto M.
- Journal Title
  
  Gastroenterology
  
  Volume: 149 Issue: 7 Pages: 1700-1715
- DOI
  10.1053/j.gastro.2015.08.054
- NAID
  120005848418
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-26460968, KAKENHI-PROJECT-25460926, KAKENHI-PROJECT-19K08369
[Journal Article] Cellular senescence checkpoint function determines different Notch1-dependent oncogenic and tumor-suppressor activities.2014
- Author(s)
  Shingo Kagawa, Mitsuteru Natsuizaka, KA Whelan, N Facompre, Seiji Naganuma, Shinya Ohashi, Hiroaki Kinugasa, AM Egloff, D Basu, PA Gimotty, AJ Klein-Szanto, AJ Bass, KK Wong, JA Diehl, AK Rustgi, Hiroshi Nakagawa
- Journal Title
  
  Oncogene
  
  Volume: 34巻18号 Issue: 18 Pages: 2347-2359
- DOI
  10.1038/onc.2014.169
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-25460926
[Journal Article] Impairment of aldehyde dehydrogenase 2 increases accumulation of acetaldehyde-derived DNA damage in the esophagus after ethanol ingestion2014
- Author(s)
  Yoshiyuki Yukawa, Shinya Ohashi, Yusuke Amanuma, Yukie Nakai, Mihoko tsurumaki, Osamu Kikuchi, Shin'ichi Miyamoto, Tsunehiro Oyama, Toshihiro Kawamoto, Tsutomu Chiba, Tomonari Matsuda, Manabu Muto
- Journal Title
  
  Am J Cancer Res
  
  Volume: 未定
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-25460926
[Journal Article] Education and imaging. Gastrointestinal : epidermal metaplasia of the esophagus.2006
- Author(s)
  Fukui T, Sakurai T, Miyamoto S, Ueno S, Kido M, Kiriya K, Inoue S, Ohashi S, Nishio A, Chiba T.
- Journal Title
  
  Journal of Gastroenterology and Hepatology 21(10)
  
  Pages: 1627-1627
- Data Source
  KAKENHI-PROJECT-16390386
[Journal Article] Overexpression of redox-active protein thioredoxin-1 prevents development of chronic pancreatitis in mice.2006
- Author(s)
  Ohashi S, Nishio A, Nakamura H, Asada M, Tamaki H, Kawasaki K, Fukui T, Yodoi J, Chiba T.
- Journal Title
  
  Antioxid Redox Signal. 8(9-10)
  
  Pages: 1835-1845
- Data Source
  KAKENHI-PROJECT-16390386
[Journal Article] Acute cerebral infarction during combination chemotherapy with s-1 and cisplatin for a young patient with a mucin- producing adenocarcinoma of the stomach.2006
- Author(s)
  Ohashi S, Yazumi S, Nishio A, Fukui T, Asada M, Chiba T.
- Journal Title
  
  Internal Medicine 45(18)
  
  Pages: 1049-1053
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16390386
[Journal Article] Education and imaging. Gastrointestinal : MALT lymphoma of the terminal ileum.2006
- Author(s)
  Ohashi S, Yazumi S, Watanabe N, Matsumoto S, Fukui T, Nishio A, Chiba T
- Journal Title
  
  Journal of Gastroenterology and Hepatology. 21(9)
  
  Pages: 1495-1495
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-16390386
[Journal Article] Acute cerebral infarction during combination chemotherapy with s-1 and cisplatin for a young patient with a mucin-producing adenocarcinoma of the stomach.2006
- Author(s)
  Ohashi S, Yazumi S, Nishio A, Fukui T, Asada M, Chiba T.
- Journal Title
  
  Internal Medicine. 45(18)
  
  Pages: 1049-1053
- Data Source
  KAKENHI-PROJECT-16390386
[Journal Article] Clinical significance of serum thioredoxin 1 levels in patients with acute pancreatitis.2006
- Author(s)
  Ohashi S, Nishio A, Nakamura H, Kido M, Kiriya K, Asada M, Tamaki H, Fukui T, Kawasaki K, Watanabe N, Yodoi J, Okazaki K, Chiba T
- Journal Title
  
  Pancreas. 32(3)
  
  Pages: 264-270
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-16390386
[Journal Article] Education and imaging. Gastrointestinal : epidermal metaplasia of the esophagus.2006
- Author(s)
  Fukui T, Sakurai T, Miyamoto S, Ueno S, Kido M, Kiriya K, Inoue S, Ohashi S, Nishio A, Chiba T.
- Journal Title
  
  Journal of Gastroenterology and Hepatology 8(9-10)
  
  Pages: 1627-1627
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16390386
[Journal Article] Education and imaging. Gastrointestinal : MALT lymphoma of the terminal ileum.2006
- Author(s)
  Ohashi S, Yazumi S, Watanabe N, Matsumoto S, Fukui T, Nishio A, Chiba T.
- Journal Title
  
  Journal of Gastroenterology and Hepatology 21(9)
  
  Pages: 1495-1495
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16390386
[Journal Article] Acute cerebral infarction during combination chemotherapy with s-1 and cisplatin for a young patient with a mucin-producing adenocarcinoma of the stomach.2006
- Author(s)
  Ohashi S, Yazumi S, Nishio A, Fukui T, Asada M, Chiba T
- Journal Title
  
  Internal Medicine. 45(18)
  
  Pages: 1049-1053
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-16390386
[Journal Article] Identification of a novel autoantibody against pancreatic secretory trypsin inhibitor in patients with autoimmune pancreatitis.2006
- Author(s)
  Asada M, Nishio A, Uchida K, Kido M, Ueno S, Uza N, Kiriya K, Inoue S, Kitamura H, Ohashi S, Tamaki H, Fukui T, Matsuura M, Kawasaki K, Nishi T, Watanabe N, Nakase H, Chiba T, Okazaki K.
- Journal Title
  
  Pancreas. 33(1)
  
  Pages: 20-26
- NAID
  10024366307
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16390386
[Journal Article] Human thioredoxin-1 ameliorates experimental murine colitis in association with suppressed macrophage inhibitory factor production.2006
- Author(s)
  Tamaki H, Nakamura H, Nishio A, Nakase H, Ueno S, Uza N, Kido M, Inoue S, Mikami S, Asada M, Kiriya K, Kitamura H, Ohashi S, Fukui T, Kawasaki K, Matsuura M, Ishii Y, Okazaki K, Yodoi J, Chiba T
- Journal Title
  
  Gastroenterology. 131(4)
  
  Pages: 1110-1121
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-16390386
[Journal Article] Human thioredoxin-1 ameliorates experimental murine colitis in association with suppressed macrophage inhibitory factor production.2006
- Author(s)
  Tamaki H, Nakamura H, Nishio A, Nakase H, Ueno S, Uza N, Kido M, Inoue S, Mikami S, Asada M, Kiriya K, Kitamura H, Ohashi S, Fukui T, Kawasaki K, Matsuura M, Ishii Y, Okazaki K, Yodoi J, Chiba T.
- Journal Title
  
  Gastroenterology 131(4)
  
  Pages: 1110-1121
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16390386
[Journal Article] Education and imaging. Gastrointestinal : MALT lymphoma of the terminal ileum.2006
- Author(s)
  Ohashi S, Yazumi S, Watanabe N, Matsumoto S, Fukui T, Nishio A, Chiba T.
- Journal Title
  
  Journal of Gastroenterology and Hepatology. 21(9)
  
  Pages: 1495-1495
- Data Source
  KAKENHI-PROJECT-16390386
[Journal Article] Human thioredoxin-1 ameliorates experimental murine colitis in association with suppressed macrophage inhibitory factor production.2006
- Author(s)
  Tamaki H, Nakamura H, Nishio A, Nakase H, Ueno S, Uza N, Kido M, Inoue S, Mikami S, Asada M, Kiriya K Kitamura H, Ohashi S, Fukui T, Kawasahi KMatsuura M, Isii Y, Okazaki K YodoiJ, Chiba T.
- Journal Title
  
  Gastroenterology. 131(4)
  
  Pages: 1110-1121
- Data Source
  KAKENHI-PROJECT-16390386
[Journal Article] Identification of a novel autoantibody against pancreatic secretory trypsin inhibitor in patients with autoimmune pancreatitis.2006
- Author(s)
  Asada M, Nishio A, Uchida K, Kido M, Ueno S, Uza N, Kiriya K, Inoue S, Kitamura H, Ohashi S, Tamaki H, Fukui T, Matsuura M, Kawasaki K, Nishi T, Watanabe N, Nakase H, Chiba T, Okazaki K
- Journal Title
  
  Pancreas. 33(1)
  
  Pages: 20-26
- NAID
  10024366307
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-16390386
[Journal Article] Clinical significance of serum thioredoxin 1 levels in patients with acute pancreatitis.2006
- Author(s)
  Ohashi S, Nishio A, Nakamura H, Kido M, Kiriya K, Asada M, Tamaki H, Fukui T, Kawasaki K, Watanabe N, Yodoi J, Okazaki K, Chiba T.
- Journal Title
  
  Pancreas. 32(3)
  
  Pages: 264-70
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16390386
[Journal Article] Education and imaging. Gastrointestinal : epidermal metaplasia of the esophagus.2006
- Author(s)
  Fukui T, Sakurai T, Miyamoto S, Ueno S, Kido M, Kiriya K, Inoue S, Ohashi S, Nishio A, Chiba T
- Journal Title
  
  Journal of Gastroenterology and Hepatology 21(10)
  
  Pages: 1627-1627
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-16390386
[Journal Article] Clinical significance of serum thioredoxin 1 levels in patients with acute pancreatitis.2006
- Author(s)
  Ohashi S, Nishio A, Nakamura H, Kido M, Kiriya K, Asada M, Tamaki H, Fukui T, Kawasaki K, Watanabe N, Yodoi J, Okazaki K, Chiba T.
- Journal Title
  
  Pancreas. 23(3)
  
  Pages: 264-270
- Data Source
  KAKENHI-PROJECT-16390386
[Journal Article] Overexpression of redox-active protein thioredoxin-1 prevents development of chronic pancreatitis in mice.2006
- Author(s)
  Ohashi S, Nishio A, Nakamura H, Asada M, Tamaki H, Kawasaki K, Fukui T, Yodoi J, Chiba T
- Journal Title
  
  Antioxid Redox Signal. 8(9-10)
  
  Pages: 1835-1845
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-16390386
[Journal Article] Overexpression of redox-active protein thioredoxin-1 prevents development of chronic pancreatitis in mice.2006
- Author(s)
  Ohashi S, Nishio A, Nakamura H, Asada M, Tamaki H, Kawasaki K, Fukui T, Yodoi J, Chiba T.
- Journal Title
  
  Antioxid Redox Signal 8(9-10)
  
  Pages: 1835-45
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16390386
[Presentation] Trifluridine/tipiracil (TAS-102) and Wee1 inhibitor combination is an effective and tolerable candidate strategy against ESCC2023
- Author(s)
  Trang H Nguyen Vu, Osamu Kikuchi, Shinya Ohashi, Tomoki Saito, Yuki Kondo, Yosuke Mitani, Junichi Matsubara, Atsushi Yamada, Manabu Muto
- Organizer
  American Association for Cancer Research (AACR) Annual Meeting
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-22K07960
[Presentation] 食道扁平上皮癌に対するトリフルリジン・チピラシル併用化学療法の研究開発2023
- Author(s)
  菊池理、大橋真也、松原淳一、武藤学
- Organizer
  日本消化器病学会近畿支部第118回例会
- Data Source
  KAKENHI-PROJECT-22K07960
[Presentation] Synthetic lethalityによる食道扁平上皮癌に対する新たな治療戦略の確立2022
- Author(s)
  大橋真也、菊池理、武藤学
- Organizer
  第18回日本消化管学会総会学術集会
- Data Source
  KAKENHI-PROJECT-19K08369
[Presentation] アルコールによる食道扁平上皮発がんの分子メカニズム2022
- Author(s)
  大橋　真也、近藤雄紀、横山顕礼、菊池理、山田敦、武藤学
- Organizer
  第81回日本癌学会学術総会
- Data Source
  KAKENHI-PROJECT-22K07960
[Presentation] アルコールに起因する食道扁平上皮発がん機序の解明2022
- Author(s)
  大橋真也、近藤雄紀、廣橋研志郎、天沼裕介、齋藤伴樹、玉置将司、菊池理、横山顕礼、武藤学
- Organizer
  第76回日本食道学会学術集会
- Data Source
  KAKENHI-PROJECT-22K07960
[Presentation] Molecular mechanism of alcohol-related carcinogenesis of the esophagus2022
- Author(s)
  大橋　真也、横山顕礼、武藤　学
- Organizer
  第64回日本消化器病学会大会
- Data Source
  KAKENHI-PROJECT-22K07960
[Presentation] 頭頚部・食道における発癌メカニズム2020
- Author(s)
  武藤　学、横山　顕礼、大橋　真也
- Organizer
  第44回日本頭頚部癌学会
- Data Source
  KAKENHI-PROJECT-18H02692
[Presentation] 頭頚部・食道における発癌メカニズム2020
- Author(s)
  武藤　学、横山顕礼、大橋真也
- Organizer
  第44回日本頭頚部癌学会
- Data Source
  KAKENHI-PROJECT-19K08369
[Presentation] 4-ニトロキノン-オキシド(4NQO)を用いた食道扁平上皮発がんモデルの検討2020
- Author(s)
  近藤　雄紀、大橋真也　山本佳宏、貴島孝、下ノ薗将貴、田中晃司、原豪男、長沼誠二、中川裕、武藤学
- Organizer
  第74回日本食道学会学術集会
- Data Source
  KAKENHI-PROJECT-19K08369
[Presentation] The chick chorioallantoic membrane tumor model retaining a series of histological features of the parental tumor.2020
- Author(s)
  齋藤伴樹、真辺綾佳、菊池理、大橋真也、吉岡正博、武藤学
- Organizer
  第79回日本癌学会学術総会
- Data Source
  KAKENHI-PROJECT-19K08369
[Presentation] HER2-G776S mutation triggers colorectal cancer progression through loss of APC function.2020
- Author(s)
  三谷洋介、大橋真也、菊池理、中村英二郎、武藤学
- Organizer
  第79回日本癌学会学術総会
- Data Source
  KAKENHI-PROJECT-19K08369
[Presentation] 大腸癌患者から検出されたHER2　VUSのcell-based assayを用いた機能解析2019
- Author(s)
  三谷　洋介、大橋　真也、齋藤　伴樹、武藤　学
- Organizer
  第78回日本癌学会学術総会
- Data Source
  KAKENHI-PROJECT-18H02692
[Presentation] トリフルリジン・チピラシルおよびプレキサセルティブ（CHK1阻害剤）併用による食道扁平上皮癌に対する新たな治療戦略2019
- Author(s)
  大橋真也、菊池理、齋藤伴樹、近藤雄紀、三谷洋介、武藤学
- Organizer
  第78回日本癌学会学術総会
- Data Source
  KAKENHI-PROJECT-19K08369
[Presentation] Quick and highly accurate breath test for predicting ALDH2 genotyping2018
- Author(s)
  Shinya Ohashi
- Organizer
  The 4th Stanford-Taiwan ALDH2 Deficiency Research (STAR) Consortium Symposium 2018
- Invited
- Data Source
  KAKENHI-PROJECT-16K09281
[Presentation] 当院における食道がんレザフィリンPDT後遺残・再発病変に対する再PDTの有効性と安全性に関する検討2018
- Author(s)
  玉置将司、天沼裕介、堀松高博、大橋真也、武藤学
- Organizer
  第72回日本食道学会（国内学会）
- Data Source
  KAKENHI-PROJECT-16K09281
[Presentation] クリニカルシークエンス―クエンス検査により大腸癌患者から検出された稀なHER2変異(G776S)の機能解析2018
- Author(s)
  三谷洋介、大橋真也、中村英二郎、武藤学
- Organizer
  第77回日本癌学会学術総会（国内学会）
- Data Source
  KAKENHI-PROJECT-16K09281
[Presentation] 遠達効果に影響を及ぼす因子の検討2018
- Author(s)
  馬場希一郎、野村基雄、大橋真也、武藤学
- Organizer
  第77回日本癌学会学術総会（国内学会）
- Data Source
  KAKENHI-PROJECT-16K09281
[Presentation] クリニカルシークエンス検査により大腸癌患者から検出された稀なHER2変異（G776S）の機能解析2018
- Author(s)
  三谷　洋介、大橋　真也、中村　英二郎、武藤　学
- Organizer
  第77回日本癌学会学術総会　P-2119
- Data Source
  KAKENHI-PROJECT-18H02692
[Presentation] Protective effects of Alda-1, an ALDH2 activator, against alcohol-derived DNA damage in the esophagus of human ALDH2*2 (Glu504Lys) knock-in mice: activating aldehyde dehydrogenase 2 decreases DNA damage in the esophagus of mice that consume alcohol.2017
- Author(s)
  Kenshiro Hirohashi, Shinya Ohashi, Yusuke Amanuma, Yukie Nakai, Shin’ichi Miyamoto, Tomonari Matsuda, Manabu Muto.
- Organizer
  Digestive Disease Week and the 118th annual meeting of the American Gastroenterological Association
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K09281
[Presentation] 当院におけるCRT後局所遺残・再発食道癌に対するレザフィリンPDTの臨床的検討.2017
- Author(s)
  玉置将司、三谷洋介、天沼裕介、堀松高博、大橋真也、武藤学
- Organizer
  第38回日本レーザー医学会総会
- Data Source
  KAKENHI-PROJECT-16K09281
[Presentation] アルコール摂取による食道上皮DNA傷害とALDH2活性を制御する薬剤の発がん予防薬としての可能性について2017
- Author(s)
  廣橋研志郎、大橋真也、武藤学
- Organizer
  第103回日本消化器病学会総会
- Place of Presentation
  京王プラザホテル、東京都新宿区
- Year and Date
  2017-04-21
- Data Source
  KAKENHI-PROJECT-16K09281
[Presentation] セラクルミンによる食道扁平上皮癌に対する細胞傷害作用及び抗腫瘍効果2017
- Author(s)
  水本綾佳、大橋真也、中井由起恵、金井雅史、武藤学
- Organizer
  第71回日本食道学会学術集会
- Data Source
  KAKENHI-PROJECT-16K09281
[Presentation] Antitumor effect of Theracurmin® for esophageal squamous cell carcinoma2017
- Author(s)
  水本綾佳、大橋真也、武藤学
- Organizer
  第76回日本癌学会学術集会
- Data Source
  KAKENHI-PROJECT-16K09281
[Presentation] Anti-tumor effect of Theracurmin®, highly bioavailable curcumin, for esophageal squamous cell carcinoma.2017
- Author(s)
  Ayaka Mizumoto, Shinya Ohashi, Kenshiro Hirohashi, Yukie Nakai, Junichi Matsubara, Masashi Kanai, Manabu Muto.
- Organizer
  Digestive Disease Week and the 118th annual meeting of the American Gastroenterological Association
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K09281
[Presentation] Carcinogenesis and prevention of alcohol-related esophageal squamous cell carcinoma in individuals with ALDH2 gene alterations.2017
- Author(s)
  Shinya Ohashi
- Organizer
  The 3rd Stanford-Taiwan ALDH2 Deficiency Research (STAR) Consortium Symposium
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K09281
[Presentation] Differential role of mutations in clonal evolution of esophageal squamous cell mucosa.2017
- Author(s)
  Akira Yokoyama, Yusuke Amanuma, Shinya Ohashi, Ikuo Aoyama, Takahiro horimatsu, Shin’ichi Miyamoto, J.B.Brown, Yoshitaka Sato, Shigeru Tsunoda, Sachiko Minamiguchi, Satoru Miyano, Manabu Muto, Seishi Ogawa.
- Organizer
  American Association for Cancer Research (AACR) Annual Meeting 2017
- Place of Presentation
  Washington DC, USA
- Year and Date
  2017-04-03
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K09281
[Presentation] 局所遺残再発食道がんPDT治療における黒フードの有用性2017
- Author(s)
  樋口浩和、堀松高博、天沼裕介、玉置将司、大橋真也、武藤学
- Organizer
  第27回日本光線力学学会学術講演会
- Data Source
  KAKENHI-PROJECT-16K09281
[Presentation] CRT後局所遺残・再発食道癌に対するレザフィリンPDT後の光線過敏症に関する検討.2017
- Author(s)
  三谷洋介、玉置将司、天沼裕介、堀松高博、大橋真也、武藤学
- Organizer
  第38回日本レーザー医学会総会
- Data Source
  KAKENHI-PROJECT-16K09281
[Presentation] エタノール投与後マウスにおける食道組織内DNAアダクト（N2-ethylidene-dG）の動態2017
- Author(s)
  馬場希一郎、大橋真也、天沼裕介、廣橋研志郎、松原淳一、松田知成、武藤学
- Organizer
  第71回日本食道学会学術集会
- Data Source
  KAKENHI-PROJECT-16K09281
[Presentation] 当院における化学放射線療法後局所再発食道癌に対するレザフィリンPDT後の光線過敏症に関する検討2017
- Author(s)
  玉置将司、天沼裕介、堀松高博、大橋真也、武藤学
- Organizer
  第27回日本光線力学学会学術講演会
- Data Source
  KAKENHI-PROJECT-16K09281
[Presentation] トラスツズマブを用いて胃がんのHER2タンパク過剰発現を検出する新規検査キットの開発2017
- Author(s)
  吉岡正博、大橋真也、武藤　学
- Organizer
  第89回日本胃癌学会総会
- Place of Presentation
  広島国際会議場、広島県広島市
- Year and Date
  2017-03-09
- Data Source
  KAKENHI-PROJECT-16K09281
[Presentation] p53-dependent senescence contribute to suppress proliferation of esophageal epithelial cells with acetaldehyde-derived DNA damage.2016
- Author(s)
  Kenshiro Hirohashi, Yusuke Amanuma, Shinya Ohashi, Yukie Nakai, Shin’ichi Miyamoto, Hiroshi Nakagawa, Tomonori Matsuda, Manabu Muto
- Organizer
  117th annual meeting of the American Gastroenterological Association
- Place of Presentation
  San Diego, USA
- Year and Date
  2016-05-21
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K09281
[Presentation] 食道扁平上皮癌に対するセラクルミンの抗腫瘍効果2016
- Author(s)
  水本綾佳、大橋真也、武藤　学
- Organizer
  第39回日本分子生物学会年会
- Place of Presentation
  パシフィコ横浜、神奈川県横浜市
- Year and Date
  2016-12-02
- Data Source
  KAKENHI-PROJECT-16K09281
[Presentation] Alcohol-related esophageal squamous cell carcinogenesis in patients with ALDH2 gene alterations and field effects.2016
- Author(s)
  Muto Manabu, Shinya Ohashi, Masashi Tamaoki, Kenshiro Hirohashi, Ayaka Mizumoto
- Organizer
  The 8th International Symposium of Society for Aldh2 Knockout Mouse Research
- Place of Presentation
  北九州国際会議場、福岡県北九州市
- Year and Date
  2016-11-16
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K09281
[Presentation] 上皮様、間葉様の食道扁平上皮がんに対するEGFR阻害剤による分化誘導効果2016
- Author(s)
  吉岡正博、大橋真也、武藤　学
- Organizer
  第75回日本癌学会学術総会
- Place of Presentation
  パシフィコ横浜、神奈川県横浜市
- Year and Date
  2016-10-06
- Data Source
  KAKENHI-PROJECT-16K09281
[Presentation] EGFR inhibitors exert different effects on epithelail-like and mesenchymal-like esophageal squamous carcinoma cells.2016
- Author(s)
  Masahiro Yoshioka, Shinya Ohashi, Tomomi Ida, Yukie Nakai, Osamu Kikuchi, Yusuke Amanuma, Junichi Matsubara, Atsushi Yamada, Shin’ichi Miyamoto, Manabu Muto
- Organizer
  Asian Pacific Digestive Week APDW 2016
- Place of Presentation
  神戸コンベンションセンター、兵庫県神戸市
- Year and Date
  2016-11-04
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K09281
[Presentation] ALDH2 inactivation due to cyanamide exacerbates DNA damage in the esophagus of mice that consume alcohol.2016
- Author(s)
  Kenshiro Hirohashi, Shinya Ohashi, Yusuke Amanuma, Yukie Nakai, Shin’ichi Miyamoto, Tomonari Matsuda, Manabu Muto
- Organizer
  117th annual meeting of the American Gastroenterological Association
- Place of Presentation
  San Diego, USA
- Year and Date
  2016-05-24
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K09281
[Presentation] アセトアルデヒドによる食道上皮細胞傷害におけるp53依存性細胞老化の役割2016
- Author(s)
  天沼裕介、大橋真也、廣橋研志郎、松田知成、武藤学
- Organizer
  第70回日本食道学会学術集会
- Place of Presentation
  ザ・プリンス　パークタワー東京、東京都港区
- Year and Date
  2016-07-06
- Data Source
  KAKENHI-PROJECT-16K09281
[Presentation] Notch3過剰発現による食道扁平上皮分化誘導は腫瘍増生能及び5-FU抵抗性を抑制する2015
- Author(s)
  菊池理、大橋真也、天沼裕介、横山顕礼、宮本心一、松本繁巳、武藤学
- Organizer
  第69回日本食道学会学術集会
- Place of Presentation
  パシフィコ横浜（神奈川県、横浜市）
- Year and Date
  2015-07-02
- Data Source
  KAKENHI-PROJECT-25460926
[Presentation] 食道癌化学放射線療法後の局所遺残再発例に対する新規光線力学療法　-基礎研究、臨床研究から薬事承認まで-2015
- Author(s)
  大橋真也、堀松高博、武藤学
- Organizer
  日本消化器病学会近畿支部第103回例会
- Place of Presentation
  大阪国際交流センター(大阪府、大阪市）
- Year and Date
  2015-09-26
- Data Source
  KAKENHI-PROJECT-25460926
[Presentation] 食道癌に対する内視鏡的PDT治療における追加照射の安全性に関する検討2015
- Author(s)
  大橋真也、堀松高博、武藤学
- Organizer
  第28回日本レーザー医学会関西地方会
- Place of Presentation
  TKPガーデンシティ京都（京都府、京都市）
- Year and Date
  2015-07-25
- Data Source
  KAKENHI-PROJECT-25460926
[Presentation] regulation of chemotherapy resistance through epithelial-mesenchymal transition by Zinc finger E-box-binding proteins ZEB1 in esophageal squamous cell carcinoma2013
- Author(s)
  Shinya Ohashi, Osamu Kikuchi, Yasumasa Ezoe, manabu Muto
- Organizer
  Global Academic Program 2013 MD Anderson Cancer Center
- Place of Presentation
  MD Anderson Cancer Center, Houston, TX, USA
- Data Source
  KAKENHI-PROJECT-25460926
[Presentation] Photodynamic therapy induces apoptosis via reactive oxygen species in fluorouracil-resistant esophageal squamous cell carcinoma cells2013
- Author(s)
  Shinya Ohashi, Mihoko Tsurumaki, Osamu Kikuchi, Daisuke Kuriyama, Yusuke Amanuma, Yukie Nakai, Takeshi Setoyama, Shin'ichi Miyamoto, Tsutomu Chiba, Manabu Muto
- Organizer
  Digestive Disease Week and the 114th annual meeting of the American Gastroenterological Association
- Place of Presentation
  Orange County Convention Center, Orland, FL, USA
- Data Source
  KAKENHI-PROJECT-25460926
[Presentation] Potent cytotoxicity of novel photodynamic therapy with talaporfin sodium for fluorouracil-resistant esophageal sqaumous cell carcinoma in vitro.2013
- Author(s)
  Shinya Ohashi, Osamu Kikuchi, Yusuke Amanuma, Manabu Muto
- Organizer
  National Taiwan University and Kyoto University Symposium 2013
- Place of Presentation
  National Taiwan University, 台湾
- Data Source
  KAKENHI-PROJECT-25460926
[Presentation] EGFR inhibition activates Notch signaling pathway and induces esophageal squamous cancer cell differentiation
- Author(s)
  Masahiro Yoshioka, Shinya Ohashi, Osamu Kikuchi, Yusuke Amanuma, Tomomi Ida, Yukie Nakai, Shin'ichi Miyamoto, Hiroshi Nakagawa, Tsutomu Chiba, Manabu Muto
- Organizer
  GAP 2015 conference
- Place of Presentation
  Houston, USA
- Year and Date
  2015-04-14 – 2015-04-16
- Data Source
  KAKENHI-PROJECT-25460926
[Presentation] EGFR inhibition promotes differentiation of esophageal squmamous cancer cells through Notch signaling pathway
- Author(s)
  Masahiro Yoshioka, Shinya Ohashi, Osamu Kikuchi, Yusuke Amanuma, Tomomi Ida, Yukie Nakai, Hiroshi Nakagawa, Tsutomu Chiba, Manabu Muto
- Organizer
  Digestive Disease Week 2015
- Place of Presentation
  Washington DC, USA
- Year and Date
  2015-05-16 – 2015-05-19
- Data Source
  KAKENHI-PROJECT-25460926

1. Muto Manabu (40360698)

# of Collaborated Projects: 3 results

# of Collaborated Products: 7 results
2. KANAI Michiyuki (00322652)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
3. HASHIDA Hiroki (70281607)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
4. Matsuda Tomonari (50273488)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
5. 鷹巣晃昌 (90399345)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
6. 木下浩一 (60342698)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
7. 奥野恭史 (20283666)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
8. 萩原義久 (50357761)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
9. 赤澤陽子 (50549897)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
10. 井倉毅 (70335686)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
11. 横山顕礼 (20515514)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
12. 垣内伸之 (90839721)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
13. 玉置将司 (00796948)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
14. KAWAMOTO Toshihiro

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
15. MIYAMOTO Shinichi

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
16. 小川誠司

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Ohashi Shinya 大橋 真也

OHASHI Sinya 大橋 真也

Research Projects

Research Products

Co-Researchers

アルコール長期曝露による正常食道上皮に生じる変異負荷や微小環境変化の解明

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アルコールによる食道発がんメカニズムの本態解明と予防薬開発に関する研究

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Establishment of a novel therapeutic strategy for esophageal squamous cell carcinoma with the combination of trifluridine and Wee1 inhibitorPrincipal Investigator

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Establishment of innovative development scheme of anti-cancer antibody

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Synthetic lethality with FTD and CHK1 inhibitor for esophageal squamous cell carcinomaPrincipal Investigator

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Research on Biological and Clinical Significance of VUS in Cancer Clinical Sequencing

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Preventive effects of ALDH2 activator on esophageal carcinogenesisPrincipal Investigator

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Anti-tumor effects of EGFR inhibitors via cell differentiation on esophageal cancer cellsPrincipal Investigator

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内視鏡的粘膜切除後消化管粘膜欠損に対するITFの臨床応用Principal Investigator

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Investigation of the possibility of Trefoil Factor Family as a therapeutics for post-EMR (endoscopic mucosal resection) gastric ulcer

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[Journal Article] Visceral fat obesity is the key risk factor for the development of reflux erosive esophagitis in 40-69-years subjects2021

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[Journal Article] Association of local complete response with prognosis after salvage photodynamic therapy for esophageal squamous cell carcinoma.2021

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[Journal Article] Comprehensive genomic profiling for patients with chemotherapy-naive advanced cancer.2020

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Ohashi Shinya 大橋真也

OHASHI Sinya 大橋真也

[Journal Article] 気管食道科領域におけるアルコール発がん　―広域発がん現象―2018