UCHIMURA Kenji 内村健治

Researcher Number	20450835
Other IDs
Affiliation (based on the past Project Information) *help	2017 – 2019: 名古屋大学, 医学系研究科, 招へい教員 2016: 名古屋大学, 医学(系)研究科(研究院), 准教授 2016: 名古屋大学, 医学系研究科, 特任准教授 2011 – 2016: 名古屋大学, 医学(系)研究科(研究院), 特任准教授 2011: 名古屋大学, 医学系研究科, 特任准教授 … More 2011: 名古屋大学, 大学院・医学研究科生物化学講座・分子生物学分野, 特任講師 2010: 独立行政法人国立長寿医療センター(研究所), アルツハイマー病研究部・発症機序解析研究室, 室長 2010: 独立行政法人国立長寿医療研究センター, アルツハイマー病研究部, 室長 2008 – 2009: 国立長寿医療センター(研究所), アルツハイマー病研究部・発症機序解析研究室, 室長 Less
Review Section/Research Field	Principal Investigator General medical chemistry Except Principal Investigator Kidney internal medicine / Experimental pathology / Neurochemistry/Neuropharmacology / General internal medicine (including Psychosomatic medicine)
Keywords	Principal Investigator 糖鎖 / 生体分子 / 脳神経疾患 / 酵素 / 脳・神経 / 細胞・組織 Except Principal Investigator 糖鎖 / 血管内皮細胞障害 / ヘパラン硫酸プロテオグリカン / 内皮細胞 … More / 加速型馬杉腎炎 / 脱硫酸化 / Sulf2 / 細胞外スルファターゼ / 細胞傷害 / 再生 / 細胆管反応 / 肝臓 / 肝傷害 / グリア細胞 / 糖蛋白質 / 末梢神経系 / 硫酸化糖鎖 / 髄鞘 / 脳、神経 / 老化 / システム生理学 / 精神免疫学 / 心療内科学 / ストレス科学 / 再生医学 / 脳・神経 / 視床下部下垂体副腎軸 / うつ病 / サイトカイン / 免疫学 / ストレス / 心身相関 Less

脳アミロイド斑除去に関わるミクログリアの糖鎖改変による機能制御機構の解明（国際共同研究強化）Principal Investigator
- Principal Investigator
  
  内村健治
- Project Period (FY)
  2017
- Research Category
  
  Fund for the Promotion of Joint International Research (Fostering Joint International Research)
- Research Field
  
  General medical chemistry
- Research Institution
  Nagoya University
Functional analysis of sulfated glycans in ductular reactions
- Principal Investigator
  
  Hoshino Hitomi
- Project Period (FY)
  2017 – 2019
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Experimental pathology
- Research Institution
  University of Fukui
血管内皮障害を呈する腎疾患におけるSulf2の機能解析と新たな治療戦略の探求
- Principal Investigator
  
  増田智広
- Project Period (FY)
  2017 – 2018
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Kidney internal medicine
- Research Institution
  Nagoya University
Sulf2-remodeling of heparan sulfate present in brain amyloidsPrincipal Investigator
- Principal Investigator
  
  UCHIMURA Kenji
- Project Period (FY)
  2015 – 2017
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  General medical chemistry
- Research Institution
  Nagoya University
Roles of sulfated N-glycans in myelin
- Principal Investigator
  
  YOSHIMURA TAKESHI
- Project Period (FY)
  2015 – 2016
- Research Category
  
  Grant-in-Aid for Research Activity Start-up
- Research Field
  
  Neurochemistry/Neuropharmacology
- Research Institution
  Osaka University
  National Institute for Physiological Sciences
Enzymatic degradation of heparan sulfate subdomains that are accumulated in cerebral amyloid plaquesPrincipal Investigator
- Principal Investigator
  
  UCHIMURA Kenji
- Project Period (FY)
  2012 – 2014
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  General medical chemistry
- Research Institution
  Nagoya University
Role of selectin-carbohydrate interactions in rolling of cells in blood vessels of the brainPrincipal Investigator
- Principal Investigator
  
  UCHIMURA Kenji
- Project Period (FY)
  2010 – 2011
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  General medical chemistry
- Research Institution
  Nagoya University
  National Center for Geriatrics and Gerontology
Total Control of Psycho-immune-endocrine system ; revealing stress specific cytokine cascade
- Principal Investigator
  
  SEKIYAMA Atsuo
- Project Period (FY)
  2008 – 2011
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Research Field
  
  General internal medicine (including Psychosomatic medicine)
- Research Institution
  Osaka City University
  Hyogo College of Medicine

All 2019 2018 2017 2016 2015 2014 2013 2012 2011 2010 2009 2008 Other

All Journal Article Presentation

[Journal Article] The Accumulation of Heparan Sulfate S-Domains in Kidney Transthyretin Deposits Accelerates Fibril Formation and Promotes Cytotoxicity2019
- Author(s)
  Kameyama H, Uchimura K, Yamashita T, Kuwabara K, Mizuguchi M, Hung SC, Okuhira K, Masuda T, Kosugi T, Ohgita T, Saito H, Ando Y, Nishitsuji K.
- Journal Title
  
  The American Journal of Pathology
  
  Volume: 189 Issue: 2 Pages: 308-319
- DOI
  10.1016/j.ajpath.2018.09.015
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15H04841, KAKENHI-PROJECT-17H03979, KAKENHI-PROJECT-17K09694, KAKENHI-PROJECT-17K16123
[Journal Article] Role of MAdCAM-1-expressing high endothelial venule-like vessels in colitis induced in mice lacking sulfotransferases catalyzing L-selectin ligand biosynthesis.2018
- Author(s)
  Low S, Hirakawa J, Hoshino H, Uchimura K, Kawashim H, Kobayashi M
- Journal Title
  
  J Histochem Cytochem
  
  Volume: 1:22155417753363 Issue: 6 Pages: 415-425
- DOI
  10.1369/0022155417753363
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K08758, KAKENHI-PROJECT-17K19542, KAKENHI-PROJECT-16H05086, KAKENHI-PROJECT-15K08343, KAKENHI-PROJECT-15K14955, KAKENHI-PROJECT-15K18869
[Journal Article] GlcNAc6ST-1 regulates sulfation of N-glycans and myelination in the peripheral nervous system.2017
- Author(s)
  Yoshimura T, Hayashi A, Handa-Narumi M, Yagi H, Ohno N, Koike T, Yamaguchi Y, Uchimura K, Kadomatsu K, Sedzik J, Kitamura K, Kato K, Trapp BD, Baba H, Ikenaka K.
- Journal Title
  
  Sci Rep.
  
  Volume: 7 Issue: 1 Pages: 42257-42257
- DOI
  10.1038/srep42257
- Peer Reviewed / Acknowledgement Compliant / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-WRAPUP-16H01694, KAKENHI-ORGANIZER-25102001, KAKENHI-PLANNED-25102008, KAKENHI-PROJECT-15H06840, KAKENHI-PROJECT-15K15079, KAKENHI-PROJECT-15K07935, KAKENHI-PROJECT-16K18977, KAKENHI-PLANNED-25117005
[Journal Article] Sulfated glycosaminoglycans in protein aggregation diseases2017
- Author(s)
  Nishitsuji Kazuchika、Uchimura Kenji
- Journal Title
  
  Glycoconjugate Journal
  
  Volume: 34 Issue: 4 Pages: 453-466
- DOI
  10.1007/s10719-017-9769-4
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17K16123, KAKENHI-PROJECT-16KK0202
[Journal Article] Iowa Mutant Apolipoprotein A-I (ApoA-IIowa) Fibrils Target Lysosomes.2016
- Author(s)
  Kameyama H., Nakajima H., Nishitsuji K., Mikawa S., Uchimura K., Kobayashi N., Okuhira K., Saito H., and Sakashita N.
- Journal Title
  
  Sci. Rep.
  
  Volume: 6 Issue: 1 Pages: 30391-30391
- DOI
  10.1038/srep30391
- NAID
  120006534966
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-25293006, KAKENHI-PROJECT-15K19488, KAKENHI-PROJECT-15K08629, KAKENHI-PROJECT-16K08236, KAKENHI-PROJECT-16K08712, KAKENHI-PROJECT-15K08265
[Journal Article] Enthalpy-driven interactions with sulfated glycosaminoglycans promote cell membrane penetration of arginine peptides.2016
- Author(s)
  Takechi-Haraya Y, Nadai R, Kimura H, Nishitsuji K, Uchimura K, Sakai-Kato K, Ka-wakami K, Shigenaga A, Kawakami T, Otaka A, Hojo H, Sakashita N, Saito H
- Journal Title
  
  Biochimica et Biophysica Acta
  
  Volume: - Issue: 6 Pages: 1339-1349
- DOI
  10.1016/j.bbamem.2016.03.021
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-26670190, KAKENHI-PROJECT-16H04180, KAKENHI-PROJECT-15K19488, KAKENHI-PROJECT-16K08712, KAKENHI-PROJECT-15K08265
[Journal Article] The polyphenol (-)-epigallocatechin-3-gallate prevents apoA-IIowa amyloidosis in vitro and protects human embryonic kidney 293 cells against amyloid cytotoxicity.2016
- Author(s)
  Nakajima H, Nishitsuji K, Kawashima H, Kuwabara K, Mikawa S, Uchimura K, Akaji K, Kashiwada Y, Kobayashi N, Saito H, Sakashita N
- Journal Title
  
  Amyloid
  
  Volume: 23 Issue: 1 Pages: 17-25
- DOI
  10.3109/13506129.2015.1113167
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-15K08265, KAKENHI-PROJECT-25293006, KAKENHI-PROJECT-15K19488, KAKENHI-PROJECT-15K08629, KAKENHI-PROJECT-16K08712
[Journal Article] Enzymatic Remodeling of Heparan Sulfate: A Therapeutic Strategy for Systemic and Localized Amyloidoses?2016
- Author(s)
  Nishitsuji K. Saito H., and Uchimura K.
- Journal Title
  
  Neur. Regener. Res.
  
  Volume: 11 Issue: 3 Pages: 408-409
- DOI
  10.4103/1673-5374.179043
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-25293006, KAKENHI-PROJECT-15K19488, KAKENHI-PROJECT-15K08265
[Journal Article] Reduced molecular size and altered disaccharide composition of cerebral chondroitin sulfate upon Alzheimer's pathogenesis in mice.2016
- Author(s)
  Zhang, Z., Ohtake-Niimi, S., Kadomatsu, K. and Uchimura, K.
- Journal Title
  
  Nagoya J. Med. Sci.
  
  Volume: 78 Pages: 293-301
- NAID
  120005837931
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-15K08265
[Journal Article] Microglial keratan sulfate epitope elicits in central nervous tissues of transgenic model mice and patients with amyotrophic lateral sclerosis.2015
- Author(s)
  Foyez T, Takeda-Uchimura Y, Ishigaki S, Narentuya, Zhang Z, Sobue G, Kadomatsu K, Uchimura K.
- Journal Title
  
  Am J Pathol
  
  Volume: 185 Issue: 11 Pages: 3053-3065
- DOI
  10.1016/j.ajpath.2015.07.016
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-15K08265, KAKENHI-PROJECT-15K09310, KAKENHI-ORGANIZER-23110001, KAKENHI-PLANNED-23110002, KAKENHI-PLANNED-26117004
[Journal Article] Cellular Interaction and Cytotoxicity of the Iowa Mutation of Apolipoprotein A-I (ApoA-IIowa) Amyloid Mediated by Sulfate Moieties of Heparan Sulfate2015
- Author(s)
  Kuwabara, K., Nishitsuji, K., Uchimura, K., Hung, S.C., Mizuguchi, M., Nakajima, H., Mikawa, S., Kobayashi, N., Saito, H., and Sakashita, N.
- Journal Title
  
  J Biol Chem
  
  Volume: 290 Issue: 40 Pages: 24210-24221
- DOI
  10.1074/jbc.m115.652545
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K08265, KAKENHI-PROJECT-15K08629, KAKENHI-PROJECT-15K19488, KAKENHI-PROJECT-25460709, KAKENHI-PROJECT-25293006
[Journal Article] The Sulfs: expression, purification, and substrate specificity.2015
- Author(s)
  Uchimura K.
- Journal Title
  
  Methods Mol Biol.
  
  Volume: 1229 Pages: 401-412
- DOI
  10.1007/978-1-4939-1714-3_31
- ISBN
  9781493917136, 9781493917143
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-24590349
[Journal Article] Keratan sulfate: biosynthesis, structures, and biological functions.2015
- Author(s)
  Uchimura K.
- Journal Title
  
  Methods Mol Biol.
  
  Volume: 1229 Pages: 389-400
- DOI
  10.1007/978-1-4939-1714-3_30
- ISBN
  9781493917136, 9781493917143
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-24590349
[Journal Article] KSGal6ST is essential for the 6-sulfation of galactose within keratan sulfate in early postnatal brain.2014
- Author(s)
  Hoshino H, Foyez T, Ohtake-Niimi S, Takeda-Uchimura Y, Michikawa M, Kadomatsu K, Uchimura K.
- Journal Title
  
  J Histochem Cytochem.
  
  Volume: 62 Issue: 2 Pages: 145-156
- DOI
  10.1369/0022155413511619
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-ORGANIZER-23110001, KAKENHI-PLANNED-23110002, KAKENHI-PROJECT-24590349, KAKENHI-PROJECT-25461375
[Journal Article] Minocycline selectively inhibits M1 polarization of microglia2013
- Author(s)
  Kazuyoshi Kobayashi
- Journal Title
  
  Cell Death and Disease
  
  Volume: 4 Issue: 3 Pages: e525-e525
- DOI
  10.1038/cddis.2013.54
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23790360, KAKENHI-PUBLICLY-24111520, KAKENHI-PROJECT-24590349, KAKENHI-PROJECT-24591258, KAKENHI-PROJECT-24890084, KAKENHI-PROJECT-25860234
[Journal Article] Heparan sulfate subdomains that are degraded by Sulf accumulate in cerebral amyloid β plaques of Alzheimer's disease: evidence from mouse models and patients2012
- Author(s)
  Hosono-Fukao, T., Ohtake-Niimi, S., Hoshino, H., Britschgi, M., Akatsu, H., Hossain, M. M., Nishitsuji, K., van Kuppevelt, T. H., Kimata, K., Michikawa, M. Wyss-Coray, T., and Uchimura, K.
- Journal Title
  
  Am. J. Pathol
  
  Volume: 180 Pages: 2056-2067
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22790303
[Journal Article] Heparan sulfate subdomains that are degraded by Sulf accumulate in cerebral amyloid beta plaques of Alzheimer's disease2012
- Author(s)
  Hosono-Fukao T, Kenji Uchimura et al.
- Journal Title
  
  Evidence from mouse models and patients
  
  Volume: 180 Pages: 2056-2067
- Data Source
  KAKENHI-PROJECT-20249042
[Journal Article] Expression of long-form N-acetylglucosamine-6- O-sulfotransferase 1 in human high endothelial venules2012
- Author(s)
  Fujiwara, M., Kobayashi, M., Hoshino, H., Uchimura, K., Nakada, T., Masumoto, J., Sakai, Y., Fukuda, M., Nakayama, J
- Journal Title
  
  J. Histochem. Cytochem
  
  Volume: 60 Pages: 397-407
- NAID
  120007110481
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22790303
[Journal Article] RB4CD12 epitope expression and heparan sulfate disaccharide composition in brain vasculature2011
- Author(s)
  Hosono-Fukao T, Kenji Uchimura
- Journal Title
  
  J Neurosci. Res
  
  Volume: 89 Pages: 1840-1848
- Data Source
  KAKENHI-PROJECT-20249042
[Journal Article] Lipoprotein lipase is a novel Abeta-binding protein that promotes glycosaminoglycan-dependent cellular uptake of Abeta in astrocytes2011
- Author(s)
  Nishitsuji, K., Hosono, T., Uchimura, K. and Michikawa, M
- Journal Title
  
  J. Biol. Chem
  
  Volume: 286 Pages: 6393-6401
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22790303
[Journal Article] Lipoprotein lipase is a novel amyloid beta (Abeta)-binding protein that promotes glycosaminoglycan-dependent cellular uptake of Abeta in astrocytes.2011
- Author(s)
  Kenji Uchimura, 他
- Journal Title
  
  J Biol Chem
  
  Volume: 286 Pages: 6393-6401
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20249042
[Journal Article] Lipoprotein lipase is a novel amyloid beta (Abeta)-binding protein that promotes glycosaminoglycan-dependent cellular uptake of Abeta in astrocytes.2011
- Author(s)
  Kenji Uchimura
- Journal Title
  
  286
  
  Pages: 6393-6401
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20249042
[Journal Article] extracellular endosulfatases that regulate physiological functions of heparan sulfate2011
- Author(s)
  Uchimura, K
- Journal Title
  
  生化学
  
  Volume: 83 Pages: 216-223
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22790303
[Journal Article] RB4CD12 epitope expression and heparan sulfate disaccharide composition in brain vasculature2011
- Author(s)
  Hosono-Fukao, T., Ohtake-Niimi, S., Nishitsuji, K., Hossain, M. M., van Kuppevelt, T. H., Michikawa, M. and Uchimura, K.
- Journal Title
  
  J. Neurosci. Res
  
  Volume: 89 Pages: 1840-1848
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22790303
[Journal Article] Use of a phage display antibody to measure the enzymatic activity of the Sulfs.2010
- Author(s)
  Kenji Uchimura, 他
- Journal Title
  
  Methods Enzymol
  
  Volume: 480(review) Pages: 51-64
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20249042
[Journal Article] Use of a phage display antibody to measure the enzymatic activity of the Sulfs2010
- Author(s)
  Uchimura, K., Lemjabbar-Alaoui, H., van Kuppevelt, T. H. and Rosen, S. D
- Journal Title
  
  Methods Enzymol
  
  Volume: 480 Pages: 51-64
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22790303
[Journal Article] N-acetylglucosamine-6-O-sulfotransferases.2008
- Author(s)
  Uchimura K, 他
- Journal Title
  
  Experimental Glycoscience. 1
  
  Pages: 83-86
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20249042
[Journal Article] セレクチンと糖鎖2008
- Author(s)
  内村健治
- Journal Title
  
  臨床検査 52
  
  Pages: 465-471
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20249042
[Presentation] Apical membrane expression of distinct sulfated glycans is a novel marker of cholangiolocellular carcinoma.2018
- Author(s)
  Hoshino H, Ohta M, Ito M, Uchimura K, Sakai Y, Uehara T, Low S, Fukushima M, Kobayashi M.
- Organizer
  第36回日本糖質学会年会
- Data Source
  KAKENHI-PROJECT-17K08758
[Presentation] Sulfated glycoconjugates that regulate microglia functions in neurodegenerative diseases2017
- Author(s)
  Kenji Uchimura
- Organizer
  2nd scientific conference on GDR GAGosciences
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16KK0202
[Presentation] Deficiency of a sulfotransferase for sialic acid-modified keratan sulfate in microglia mitigates Alzheimer’s pathology2017
- Author(s)
  Kenji Uchimura
- Organizer
  1st International Conference on the Glycobiology of Nervous System
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16KK0202
[Presentation] Apical membrane expression of distinct sulfated glycans is a novel marker of cholangiolocellular carcinoma.2017
- Author(s)
  Hoshino H, Ohta M, Ito M, Uchimura K, Sakai Y, Uehara T, Low S, Fukushima M, Kobayashi M.
- Organizer
  第36回日本糖質学会年会
- Data Source
  KAKENHI-PROJECT-17K08758
[Presentation] Apical membrane expression of distinct sulfated glycans represents a novel marker of cholangiolocellular carcinoma.2017
- Author(s)
  Hoshino H, Ohta M, Ito M, Uchimura K, Sakai Y, Uehara T, Low S, Fukushima M, Kobayashi M
- Organizer
  第106回日本病理学会総会
- Data Source
  KAKENHI-PROJECT-17K08758
[Presentation] Sulfated N-glycans modulate myelination in the peripheral nervous system.2016
- Author(s)
  吉村武, 半田麻衣, 林明子, 矢木宏和, 山口宜秀, 内村健治, 門松健治, 加藤晃一, 馬場広子, 池中一裕
- Organizer
  第38回日本生物学的精神医学会・第59回日本神経化学会大会合同年会
- Place of Presentation
  福岡国際会議場（福岡県福岡市）
- Data Source
  KAKENHI-PROJECT-15H06840
[Presentation] GlcNAc6ST-1 regulates sulfation of N-glycans and myelination in the peripheral nervous system2015
- Author(s)
  Takeshi Yoshimura, Akiko Hayashi, Kenji Uchimura, Kenji Kadomatsu, Yoshihide Yamaguchi, Hiroko Baba, Kazuhiro Ikenaka
- Organizer
  第58回日本神経化学会大会
- Place of Presentation
  大宮ソニックシティ（埼玉県さいたま市）
- Year and Date
  2015-09-12
- Data Source
  KAKENHI-PROJECT-15H06840
[Presentation] 神経回路再編および神経変性に関わるケラタン硫酸2015
- Author(s)
  内村健治、門松健治
- Organizer
  第３４回日本糖質学会
- Place of Presentation
  東京大学（東京都文京区）
- Year and Date
  2015-08-02
- Data Source
  KAKENHI-PROJECT-15K08265
[Presentation] Gene disruption of GlcNAc 6-O-sulfotransferase-1 results in loss of microglial keratan sulfate and alleviation of Alzheimer's pathogenesis in mice2015
- Author(s)
  Zui Zhang, Yoshiko Uchimura, Tahmina Foyez, Shiori Niimi, Hitomi Hoshino, Tomomi Hosono, Makoto Michikawa, Kenji Kadomatsu and Kenji Uchimura
- Organizer
  第３８回分子生物学会年会第８８回日本生化学会大会合同年会
- Place of Presentation
  神戸ポートアイランド（兵庫県神戸市）
- Year and Date
  2015-12-03
- Data Source
  KAKENHI-PROJECT-15K08265
[Presentation] GlcNAc6ST-1 regulates sulfation of N-glycans and myelination in the peripheral nervous system.2015
- Author(s)
  Takeshi Yoshimura, Mai Handa-Narumi, Akiko Hayashi, Hirokazu Yagi, Yoshihide Yamaguchi, Kenji Uchimura, Kenji Kadomatsu, Kunio Kitamura, Koichi Kato, Bruce D. Trapp, Hiroko Baba, Kazuhiro Ikenaka.
- Organizer
  12th Biennial ISN Satellite Meeting Myelin Biology 2015
- Place of Presentation
  Fitzroy Island (Australia)
- Year and Date
  2015-08-28
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15H06840
[Presentation] GlcNAc6ST-1 regulates sulfation of N-glycans and myelination in the peripheral nervous system2015
- Author(s)
  Takeshi Yoshimura, Mai Handa-Narumi, Akiko Hayashi, Hirokazu Yagi, Yoshihide Yamaguchi, Kenji Uchimura, Kenji Kadomatsu, Koichi Kato, Hiroko Baba, Kazuhiro Ikenaka
- Organizer
  第20回グリア研究会
- Place of Presentation
  名古屋市立大学医学部研究棟（愛知県名古屋市）
- Year and Date
  2015-12-05
- Data Source
  KAKENHI-PROJECT-15H06840
[Presentation] 硫酸化糖鎖は末梢神経系髄鞘の形成を制御する2015
- Author(s)
  吉村武、半田（鳴海）麻衣、林明子、矢木宏和、内村健治、門松健治、加藤晃一、Bruce D. Trapp, 馬場広子、池中一裕
- Organizer
  糖鎖科学中部拠点・第12回若手の力フォーラム
- Place of Presentation
  名城大学薬学部（愛知県名古屋市）
- Year and Date
  2015-11-28
- Data Source
  KAKENHI-PROJECT-15H06840
[Presentation] GlcNAc6ST-1はN結合型糖鎖の硫酸化を介して末梢神経系の髄鞘形成を制御する2015
- Author(s)
  吉村武、半田麻衣、林明子、矢木宏和、内村健治、門松健治、加藤晃一、馬場広子、池中一裕
- Organizer
  第5回名古屋大学医学系研究科・生理学研究所合同シンポジウム
- Place of Presentation
  生理学研究所大会議室（愛知県岡崎市）
- Year and Date
  2015-09-19
- Data Source
  KAKENHI-PROJECT-15H06840
[Presentation] Structure and function of keratan sulfate expressed in the brain of Alzheimer disease model mice2014
- Author(s)
  Tahmina Foyez, Yoshiko Uchimura, Shiori Niimi, Hitomi Hoshino, Makoto Michikawa Kenji Kadomatsu and Kenji Uchimura
- Organizer
  第33回日本糖質学会
- Place of Presentation
  名古屋大学（愛知県名古屋市）
- Year and Date
  2014-08-11
- Data Source
  KAKENHI-PROJECT-24590349
[Presentation] 神経回路再編および神経変性に関わる細胞外硫酸化糖鎖2014
- Author(s)
  内村健治、門松健治
- Organizer
  第57回日本神経化学会大会
- Place of Presentation
  奈良県新公会堂（奈良県奈良市）
- Year and Date
  2014-09-29
- Invited
- Data Source
  KAKENHI-PROJECT-24590349
[Presentation] Deficiency in C-6 sulfation of GlcNAc within keratan sulfate mitigates Alzheimer’s pathology and memory impairment in mice2014
- Author(s)
  Shiori Ohtake-Niimi, Yoshiko Takeda-Uchimura, Tahmina Foyez, Hitomi Hoshino, Makoto Michikawa, Kenji Kadomatsu and Kenji Uchimura
- Organizer
  Annual meeting of Glycobiology 2014
- Place of Presentation
  Honolulu, USA
- Year and Date
  2014-11-17
- Data Source
  KAKENHI-PROJECT-24590349
[Presentation] アルツハイマー病モデルマウス脳内に発現するケラタン硫酸糖鎖の構造機能解析2013
- Author(s)
  新美しおり、星野瞳、タミナフォエズ、マーカスブリチギ、門松健治、道川誠、トニーワイスコレイ、内村健治
- Organizer
  第32回日本認知症学会
- Place of Presentation
  キッセイ文化ホール（松本市）
- Data Source
  KAKENHI-PROJECT-24590349
[Presentation] Keratan sulfate: development and pathology2012
- Author(s)
  Kenji Uchimura
- Organizer
  IBMS Glycobiology meeting
- Place of Presentation
  Taiwan
- Year and Date
  2012-01-10
- Data Source
  KAKENHI-PROJECT-22790303
[Presentation] Heparan sulfate S-domains that are degraded by Sulf accumulate in cerebral amyloid beta plaques of Alzheimer’s disease, Evidence from mouse models and patients2012
- Author(s)
  Kenji Uchimura
- Organizer
  Annual meeting of Glycobiology 2012
- Place of Presentation
  San Diego, USA
- Data Source
  KAKENHI-PROJECT-24590349
[Presentation] Heparan sulfate S-domains that are degraded by Sulf accumulate in cerebral amyloid beta plaques of Alzheimer’s disease2012
- Author(s)
  Kenji Uchimura
- Organizer
  Global COE symposium on Neuro-Tumor Biology and Medicine
- Place of Presentation
  Nagoya
- Data Source
  KAKENHI-PROJECT-24590349
[Presentation] アルツハイマー病モデルマウス脳に発現する細胞外マトリックスコンドロイチン硫酸糖鎖の構造解析2011
- Author(s)
  新美しおり, 星野瞳, 細野友美,道川誠, 内村健治
- Organizer
  第30回日本認知症学会
- Place of Presentation
  東京
- Year and Date
  2011-11-12
- Data Source
  KAKENHI-PROJECT-22790303
[Presentation] Cahbohydrate-protein interactions in the vasculature2011
- Author(s)
  Kenji Uchimura
- Organizer
  IBMS Seminar, Academia Sinica
- Place of Presentation
  Taiwan
- Year and Date
  2011-10-17
- Data Source
  KAKENHI-PROJECT-22790303
[Presentation] Sulfotransferases that regulate expression of the 5D4 keratan sulfate epitope in early postnatal mouse brain Hitomi Hoshino2011
- Author(s)
  Shiori Ohtake-Niimi, Makoto Michikawa, Reiji Kannagi, and Kenji Uchimura
- Organizer
  Annual meeting of Glycobiology 2011
- Place of Presentation
  Seattle, USA
- Year and Date
  2011-11-11
- Data Source
  KAKENHI-PROJECT-22790303
[Presentation] アルツハイマー病モデルマウス脳に発現するコンドロイチン硫酸グリコサミノグリカンの構造解析2011
- Author(s)
  新美しおり, 星野瞳, 道川誠, 門松健治, 内村健治
- Organizer
  第84回日本生化学会大会
- Place of Presentation
  京都
- Year and Date
  2011-09-23
- Data Source
  KAKENHI-PROJECT-22790303
[Presentation] セレクチンリガンド形成に関わる硫酸転移酵素は生後マウス発達脳における 5D4ケラタン硫酸糖鎖抗原の発現を制御する星野瞳2011
- Author(s)
  道川誠, 神奈木玲児, 内村健治
- Organizer
  第84回日本生化学会大会
- Place of Presentation
  京都
- Year and Date
  2011-09-23
- Data Source
  KAKENHI-PROJECT-22790303
[Presentation] アルツハイマー病モデルマウス大脳皮質に発現するヘパラン硫酸グリコサミノグリカンの構造解析2010
- Author(s)
  細野友美, 新美しおり, ホサインモタラブ, 菅谷典子, 赤津裕康, トニーワイスコレイ, 木全弘治, 道川誠, 内村健治
- Organizer
  第83回日本生化学会大会
- Place of Presentation
  神戸
- Year and Date
  2010-12-09
- Data Source
  KAKENHI-PROJECT-22790303
[Presentation] Immunolocalization of the RB4CD12 Anti-Heparan Sulfate Epitope in Brain Microvessels and Its Degradation by Sulf-1 and Sulf-22010
- Author(s)
  Hosono-Fukao T, Hossain M, Ohtake-Niimi S , van Kuppevelt T, Michikawa M, Rosen S and Uchimura K
- Organizer
  Annual meeting of Glycobiology 2010
- Place of Presentation
  St. Pete Beach, USA
- Year and Date
  2010-11-08
- Data Source
  KAKENHI-PROJECT-22790303
[Presentation] アルツハイマー病モデルマウス脳内に発現するヘパラン硫酸糖鎖の内部ドメイン構造の解析2010
- Author(s)
  細野友美, 新美しおり, モタラブホサイン, マーカスブリッチギ, 赤津裕康, 菅谷典子, 木全弘治, 道川誠, トニーワイスコレイ, 内村健治
- Organizer
  第29回日本認知症学会
- Place of Presentation
  名古屋
- Year and Date
  2010-11-05
- Data Source
  KAKENHI-PROJECT-22790303
[Presentation] Immunolocalization of the RB4CD12 anti-heparan sulfate epitope in the brain and its degradation by Sulfs, extracellular endosulfatases2010
- Author(s)
  Hossain M, Hosono T, Niimi S, van Kuppevelt T, Michikawa M, Rosen S, Uchimura K.
- Organizer
  25th International Carbohydrate Symposium (ICS2010) Makuhari Messe
- Place of Presentation
  Makuhari
- Year and Date
  2010-08-05
- Data Source
  KAKENHI-PROJECT-22790303
[Presentation] The Sulf-degrading heparan sulfate epitope accumulates in cerebral amyloid β plaques of mouse models and patients of Alzheimer's disease2010
- Author(s)
  Hosono T, Hossain M, Britschgi M, Akatsu H, van Kuppevelt T, Michikawa M,Wyss-Coray T, Uchimura K.
- Organizer
  25th International Carbohydrate Symposium (ICS2010) Makuhari Messe
- Place of Presentation
  Makuhari
- Year and Date
  2010-08-02
- Data Source
  KAKENHI-PROJECT-22790303
[Presentation] Sulfated endothelial ligands involved in cell migration into lymph nodes2009
- Author(s)
  Kenji Uchimura
- Organizer
  IMMAG Seminar, Medical College of Georgia
- Place of Presentation
  Augusta, USA
- Year and Date
  2009-10-15
- Data Source
  KAKENHI-PROJECT-20249042
[Presentation] リンパ球血管外遊走におけるセレクチンリガンド糖鎖の硫酸化2008
- Author(s)
  内村健治
- Organizer
  第6回糖鎖科学コンソーシアムシンポジウム
- Place of Presentation
  品川、日本
- Year and Date
  2008-12-04
- Data Source
  KAKENHI-PROJECT-20249042
[Presentation] アルツハイマー病と糖鎖生物学 : モデル動物を用いた解析2008
- Author(s)
  内村健治
- Organizer
  第2回GFRG研究会
- Place of Presentation
  東京、日本
- Year and Date
  2008-09-18
- Data Source
  KAKENHI-PROJECT-20249042
[Presentation] セレクチンリガンド糖鎖の硫酸化とリンパ球血管外遊走メカニズム2008
- Author(s)
  内村健治
- Organizer
  第19回プロテオグリカン特別講演会
- Place of Presentation
  札幌、日本
- Year and Date
  2008-10-28
- Data Source
  KAKENHI-PROJECT-20249042
[Presentation] 神経変性疾患の組織病変に伴い発現するケラタン硫酸糖鎖抗原の解析
- Author(s)
  内村健治, Tahmina Foyez, 門松健治
- Organizer
  第86回日本生化学会大会
- Place of Presentation
  （パシフィコ横浜）横浜市
- Data Source
  KAKENHI-PROJECT-24590349

1. KADOMATSU Kenji (80204519)

# of Collaborated Projects: 3 results

# of Collaborated Products: 17 results
2. SEKIYAMA Atsuo (30403702)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
3. KASAHARA Emiko (30468269)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
4. CHIDA Dai (90312842)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
5. OKAMURA Haruki (60111043)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
6. INOUE Masayasu (80040278)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
7. YOSHIMURA TAKESHI (60402567)

# of Collaborated Projects: 1 results

# of Collaborated Products: 6 results
8. BABA Hiroko (40271499)

# of Collaborated Projects: 1 results

# of Collaborated Products: 6 results
9. HAYASHI Akiko (90232090)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
10. OHNO Nobuhiko (10432155)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
11. Hoshino Hitomi (90500710)

# of Collaborated Projects: 1 results

# of Collaborated Products: 4 results
12. 小林基弘 (00362137)

# of Collaborated Projects: 1 results

# of Collaborated Products: 4 results
13. 増田智広 (70792646)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
14. 丸山彰一 (10362253)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
15. 小杉智規 (90584681)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
16. 安東由喜雄

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
17. 山下太郎

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
18. 安藤明子

# of Collaborated Projects: 0 results

# of Collaborated Products: 6 results
19. 斎藤博幸

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results
20. 赤路健一

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
21. 小林典裕

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
22. 坂下直実

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
23. 西辻和親

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results

UCHIMURA Kenji 内村 健治

Research Projects

Research Products

Co-Researchers

脳アミロイド斑除去に関わるミクログリアの糖鎖改変による機能制御機構の解明（国際共同研究強化）Principal Investigator

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Functional analysis of sulfated glycans in ductular reactions

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血管内皮障害を呈する腎疾患におけるSulf2の機能解析と新たな治療戦略の探求

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Sulf2-remodeling of heparan sulfate present in brain amyloidsPrincipal Investigator

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Roles of sulfated N-glycans in myelin

Principal Investigator

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Enzymatic degradation of heparan sulfate subdomains that are accumulated in cerebral amyloid plaquesPrincipal Investigator

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Role of selectin-carbohydrate interactions in rolling of cells in blood vessels of the brainPrincipal Investigator

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Total Control of Psycho-immune-endocrine system ; revealing stress specific cytokine cascade

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[Journal Article] The Accumulation of Heparan Sulfate S-Domains in Kidney Transthyretin Deposits Accelerates Fibril Formation and Promotes Cytotoxicity2019

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[Journal Article] Role of MAdCAM-1-expressing high endothelial venule-like vessels in colitis induced in mice lacking sulfotransferases catalyzing L-selectin ligand biosynthesis.2018

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[Journal Article] GlcNAc6ST-1 regulates sulfation of N-glycans and myelination in the peripheral nervous system.2017

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[Journal Article] Sulfated glycosaminoglycans in protein aggregation diseases2017

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[Journal Article] Iowa Mutant Apolipoprotein A-I (ApoA-IIowa) Fibrils Target Lysosomes.2016

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NAID

Data Source

[Journal Article] Enthalpy-driven interactions with sulfated glycosaminoglycans promote cell membrane penetration of arginine peptides.2016

Author(s)

UCHIMURA Kenji 内村健治