TANAKA Masakazu 田中正和

Researcher Number	20454613
Other IDs	https://orcid.org/0000-0003-4098-385X
Affiliation (Current)	2025: 鹿児島大学, 医歯学域ヒトレトロウイルス学系, 准教授
Affiliation (based on the past Project Information) *help	2022 – 2024: 鹿児島大学, 医歯学域ヒトレトロウイルス学系, 准教授 2019 – 2021: 鹿児島大学, 総合科学域総合研究学系, 准教授 2009 – 2016: 関西医科大学, 医学部, 助教
Review Section/Research Field	Principal Investigator Tumor biology Except Principal Investigator Basic Section 54030:Infectious disease medicine-related / Basic Section 52020:Neurology-related / Neurology / Virology
Keywords	Principal Investigator インターフェロン / ウイルス感染 / CD25 / APOBEC３ / APOBEC / Tax / ヒト化マウス / HTLV-1 Except Principal Investigator HTLV-1 / HAM … More / gdT細胞 / NKT細胞 / 自然免疫 / TLR / NKT / innate immunity / 治療法開発 / 感染細胞 / HTLV-1 HAM / infected cell / 樹状細胞 / 感染モデル / NOG-SCID / ATL / マウスモデル / ヒト化マウス Less

Pathogenesis of HTLV-1-associated myelopathy (HAM) by innate immune analysis and development of new treatment methods
- Principal Investigator
  
  久保田龍二
- Project Period (FY)
  2022 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 54030:Infectious disease medicine-related
- Research Institution
  Kagoshima University
Development of a new treatment for HAM/TSP targeting HTLV-1-infected cells
- Principal Investigator
  
  Kubota Ryuji
- Project Period (FY)
  2019 – 2021
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 52020:Neurology-related
- Research Institution
  Kagoshima University
Elucidation of the gene variation accumulation mechanism in the tumor developmental process using HTLV -1 humanized mousePrincipal Investigator
- Principal Investigator
  
  TANAKA Masakazu
- Project Period (FY)
  2014 – 2016
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Tumor biology
- Research Institution
  Kansai Medical University
Establishment of HTLV-1 infection model via dendritic cells and the use to screening of medicines.
- Principal Investigator
  
  TAKENOUCHI Norihiro
- Project Period (FY)
  2012 – 2014
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Neurology
- Research Institution
  Kansai Medical University
Study of mechanism for the development of ATL and HAM by using HTLV-1 infected humanized mouse model
- Principal Investigator
  
  FUJISAWA Jun-ichi
- Project Period (FY)
  2009 – 2011
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Virology
- Research Institution
  Kansai Medical University

All 2024 2023 2022 2021 2020 2019 2016 2015 2014 2013 2012 2011 2010 2009

All Journal Article Presentation Patent

[Journal Article] Geographic characteristics of HTLV-1 molecular subgroups and genetic substitutions in East Asia: Insights from complete genome sequencing of HTLV-1 strains isolated in Taiwan and Japan2024
- Author(s)
  Nozuma Satoshi、Yoshimura Akiko、Pai Shun-Chung、Chen Hung-Jen、Matsuura Eiji、Tanaka Masakazu、Kodama Daisuke、Dozono Mika、Matsuzaki Toshio、Takashima Hiroshi、Yang Ya-Chien、Kubota Ryuji
- Journal Title
  
  PLOS Neglected Tropical Diseases
  
  Volume: 18 Issue: 2 Pages: e0011928-e0011928
- DOI
  10.1371/journal.pntd.0011928
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21K07418, KAKENHI-PROJECT-23K24380
[Journal Article] Anti-ganglionic acetylcholine receptor antibodies in functional neurological symptom disorder/conversion disorder2023
- Author(s)
  Nagata Ryusei、Matsuura Eiji、Nozuma Satoshi、Dozono Mika、Noguchi Yutaka、Ando Masahiro、Hiramatsu Yu、Kodama Daisuke、Tanaka Masakazu、Kubota Ryuji、Yamakuchi Munekazu、Higuchi Yujiro、Sakiyama Yusuke、Arata Hitoshi、Higashi Keiko、Hashiguchi Teruto、Nakane Shunya、Takashima Hiroshi
- Journal Title
  
  Frontiers in Neurology
  
  Volume: 14 Pages: 01-07
- DOI
  10.3389/fneur.2023.1137958
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-21K19454, KAKENHI-PROJECT-23K24234, KAKENHI-PROJECT-23K24380
[Journal Article] Identification and tracking of HTLV-1-infected T cell clones in virus-associated neurologic disease2023
- Author(s)
  Nozuma S, Matsuura E, Tanaka M, Kodama D, Matsuzaki T, Yoshimura A, Sakiyama Y, Nakahata S, Morishita K, Enose-Akahata Y, Jacoboson S, Kubota R, Takashima H.
- Journal Title
  
  JCI Insight.
  
  Volume: 8 Issue: 7 Pages: 237-245
- DOI
  10.1172/jci.insight.167422
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21K07418, KAKENHI-PROJECT-23K24380
[Journal Article] Iliopsoas Muscle Weakness as a Key Diagnostic Marker in HTLV-1-Associated Myelopathy/Tropical Spastic Paraparesis (HAM/TSP)2023
- Author(s)
  Matsuura Eiji、Nozuma Satoshi、Dozono Mika、Kodama Daisuke、Tanaka Masakazu、Kubota Ryuji、Takashima Hiroshi
- Journal Title
  
  Pathogens
  
  Volume: 12 Issue: 4 Pages: 592-592
- DOI
  10.3390/pathogens12040592
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-21K07418, KAKENHI-PROJECT-23K24380
[Journal Article] Efficacy of L-Arginine Treatment in Patients with HTLV-1-Associated Neurological Disease.2023
- Author(s)
  Satoshi Nozuma, Eiji Matsuura, Yuichi Tashiro, Ryusei Nagata, Masahiro Ando, Yu Hiramatsu, Yujiro Higuchi, Yusuke Sakiyama, Akihiro Hashiguchi, Kumiko Michizono, Keiko Higashi, Toshio Matsuzaki, Daisuke Kodama, Masakazu Tanaka, Yoshihisa Yamano, Takashi Moritoyo, Ryuji Kubota, Hiroshi Takashima.
- Journal Title
  
  Ann Clin Transl Neurol.
  
  Volume: 10 Issue: 2 Pages: 237-245
- DOI
  10.1002/acn3.51715
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21K07418, KAKENHI-PROJECT-23K24248, KAKENHI-PROJECT-23K24380
[Journal Article] HTLV-1-associated myelopathy/tropical spastic paraplegia with sporadic late-onset nemaline myopathy: a case report2023
- Author(s)
  Matsuura Eiji、Nozuma Satoshi、Shigehisa Ayano、Dozono Mika、Nakamura Tomonori、Tanaka Masakazu、Kubota Ryuji、Hashiguchi Akihiro、Takashima Hiroshi
- Journal Title
  
  BMC Musculoskeletal Disorders
  
  Volume: 24 Issue: 1 Pages: 355-355
- DOI
  10.1186/s12891-023-06461-3
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-21K07418, KAKENHI-PROJECT-23K24380
[Journal Article] High Prevalence of HTLV-1 Carriers Among the Elderly Population in Kagoshima, a Highly Endemic Area in Japan2022
- Author(s)
  46.Tashiro Y, Matsuura E, Sagara Y, Nozuma S, Kodama D, Tanaka M, Koriyama C, Kubota R, Takashima H.
- Journal Title
  
  AIDS Res Hum Retroviruses.
  
  Volume: 38 Issue: 5 Pages: 363-369
- DOI
  10.1089/aid.2021.0164
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21K07418, KAKENHI-PROJECT-23K24380, KAKENHI-PROJECT-22H04923
[Journal Article] Anti-human T-cell leukemia virus type 1 (HTLV-1) antibody assays in cerebrospinal fluid for the diagnosis of HTLV-1-associated myelopathy/tropical spastic paraparesis2021
- Author(s)
  Kodama Daisuke, Tanaka Masakazu, Matsuzaki Toshio, Nozuma Satoshi, Matsuura Eiji, Takashima Hiroshi, Izumo Shuji, Kubota Ryuji
- Journal Title
  
  Journal of Clinical Microbiology
  
  Volume: - Issue: 5
- DOI
  10.1128/jcm.03230-20
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K07999, KAKENHI-PROJECT-20K22879, KAKENHI-PROJECT-16K11268
[Journal Article] Inhibition of ABL1 tyrosine kinase reduces HTLV-1 proviral loads in peripheral blood mononuclear cells from patients with HTLV-1-associated myelopathy/tropical spastic paraparesis2020
- Author(s)
  Kodama Daisuke, Tanaka Masakazu, Matsuzaki Toshio, Izumo Kimiko, Nakano Nobuaki, Matsuura Eiji, Saito Mineki, Nagai Masahiro, Horiuchi Masahisa, Utsunomiya Atae, Takashima Hiroshi, Kubota Ryuji, Izumo Shuji
- Journal Title
  
  PLOS Neglected Tropical Diseases
  
  Volume: 14 Issue: 7 Pages: e0008361-e0008361
- DOI
  10.1371/journal.pntd.0008361
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K07999, KAKENHI-PROJECT-18K07541
[Journal Article] Expression of TSLC1 in patients with HAM/TSP2020
- Author(s)
  Takenouchi N, Tanaka M, Sato T, Yao J, Fujisawa JI, Izumo S, Kubota R, Matsuura E.
- Journal Title
  
  J Neurovirol
  
  Volume: 26 Issue: 3 Pages: 404-414
- DOI
  10.1007/s13365-020-00838-z
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16K11268, KAKENHI-PROJECT-19K07999
[Journal Article] Effects of radiation based on whole-body irradiation in HTLV-1-infected mice.2019
- Author(s)
  M. Tanaka, Y. Kawazu, T. Yoshida, T. Konishi, N. Takenouchi, M. Miwa.
- Journal Title
  
  J Radiat Res.
  
  Volume: 60 Issue: 5 Pages: 710-713
- DOI
  10.1093/jrr/rrz050
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19K07999
[Journal Article] Conflicting effects of poly(ADP-ribose)polymerase inhibitor on cell-mediated and virion-mediated HTLV-1 infection.2019
- Author(s)
  M. Tanaka, K. Tanaka, C. Ida, A. Oue, S. Yamashita, J. Yao, N. Takenouchi, M. Miwa.
- Journal Title
  
  Virus Res.
  
  Volume: 270 Pages: 197653-197653
- DOI
  10.1016/j.virusres.2019.197653
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19K07999
[Journal Article] Induction of APOBEC3B cytidine deaminase in HTLV‐1‐infected humanized mice2019
- Author(s)
  Yao J, Tanaka M, Takenouchi N, Ren Y, Lee S-I, Fujisawa J-I
- Journal Title
  
  Experimental and Therapeutic Medicine
  
  Volume: 17 Pages: 3701-3708
- DOI
  10.3892/etm.2019.7375
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K07152, KAKENHI-PROJECT-19K07999
[Journal Article] Effect of mild temperature shift on poly(ADP-ribose) and γH2AX levels in cultured cells.2016
- Author(s)
  S. Yamashita, M. Tanaka, T. Sato, C. Ida, N. Ohta, T. Hamada, T. Uetsuki, Y. Nishi, J. Moss, M. Miwa.
- Journal Title
  
  Biochem. Biophys. Res. Commun.
  
  Volume: 476 Pages: 594-599
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26430126
[Journal Article] An enzyme-linked immunosorbent assay-based system for determining the physiological level of poly(ADP-ribose)in cultured cells.2016
- Author(s)
  C. Ida, S. Yamashita, M. Tsukada, T. Eguchi, M. Tanaka, S. Ogata, T. Fujii, Y. Nishi, S. Ikegami, J. Moss, M. Miwa.
- Journal Title
  
  Anal. Biochem.
  
  Volume: 494 Pages: 76-81
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26430126
[Journal Article] Induction of APOBEC3B cytidine deaminase gene in HTLV-1 infected T-cells of ATL model mouse2015
- Author(s)
  Masakazu Tanaka, Jinchun Yao, Sung-il Lee, Yihua Ren, Norihiro Takenouchi, Jun-ichi Fujisawa
- Journal Title
  
  Retrovirology
  
  Volume: 12(Suppl1) Issue: S1 Pages: 043-043
- DOI
  10.1186/1742-4690-12-s1-p11
- Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K08506, KAKENHI-PROJECT-26430126
[Journal Article] Tax peptide vaccine suppressed the leukemia in humanized mouse2015
- Author(s)
  Jun-ichi Fujisawa, Sung-il Lee, Jinchun Yao, Yihua Ren, Masakazu Tanaka
- Journal Title
  
  Retrovirology
  
  Volume: 12(Suppl1) Issue: S1
- DOI
  10.1186/1742-4690-12-s1-o43
- Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K08506, KAKENHI-PROJECT-26430126
[Journal Article] An animal model of adult T-cell leukemia: humanized mice with HTLV-1-specific immunity2014
- Author(s)
  Tezuka K, Xun R, Tei M, Ueno T, Tanaka M, Takenouchi N, Fujisawa J
- Journal Title
  
  Blood
  
  Volume: 123 Issue: 3 Pages: 346-355
- DOI
  10.1182/blood-2013-06-508861
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24590562, KAKENHI-PROJECT-24591280, KAKENHI-PROJECT-25860729
[Journal Article] HTLV-1のTax発現リンパ腫のウシラクトフェリンによる腫瘍増殖抑制効果2013
- Author(s)
  田中正和, 和田直樹, 橋本岩雄, 竹之内徳博, 津田洋幸, 藤澤順一, 三輪正直.
- Journal Title
  
  ラクトフェリン2013
  
  Volume: 1 Pages: 43-50
- Data Source
  KAKENHI-PROJECT-24591280
[Journal Article] The route of primary HTLV-1 infection regulates HTLV-1 distribution in reservoir organs of infected mice2011
- Author(s)
  Tanaka M, Nitta T, Sun B, Fujisawa J, Miwa M
- Journal Title
  
  Exp. Thr. Med
  
  Volume: vol.2 Pages: 89-94
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21590515
[Journal Article] Route of primary HTLV-1 infection regulates HTLV-1 distribution in reservoir organs of infected mice2011
- Author(s)
  Tanaka M, Nitta T, Sun B, Fujisawa J, Miwa M
- Journal Title
  
  Exp.Thr.Med.
  
  Volume: 12 Issue: 1 Pages: 89-94
- DOI
  10.3892/etm.2010.179
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21590515
[Journal Article] Neuraminidase enhances the initial steps of human T-cell leukemia virus type 1 replication2010
- Author(s)
  Tanaka M, Sun B, Tezuka K, Fujisawa J, Tanaka Y, Hoshino H, Miwa M
- Journal Title
  
  Microbes and Infection
  
  Volume: vol.12 Pages: 701-707
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21590515
[Journal Article] Clonal proliferation of HTLV-1-infected cells is associated with spontaneous malignant tumor formation in mice2009
- Author(s)
  Tanaka, M., T. Nitta, T. Yoshida, T. Konishi, Y. Kawazu, J. Fujisawa and M. Miwa
- Journal Title
  
  Int J Oncol
  
  Volume: vol.35 Pages: 119-125
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21590515
[Journal Article] Clonal proliferation of HTLV-1-infected cells is associated with spontaneous malignant tumor formation in mice2009
- Author(s)
  Tanaka, M., T.Nitta, T.Yoshida, T.Konishi, Y.Kawazu, J.Fujisawa, M.Miwa
- Journal Title
  
  Int J Oncol 35
  
  Pages: 701-707
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21590515
[Journal Article] Involvement of TORC2, a CREB co-activator, in the in vivo-specific transcriptional control of HTLV-12009
- Author(s)
  Jiang S, Inada T, Tanaka M, Furuta RA, Shingu K, Fujisawa J
- Journal Title
  
  Retrovirology
  
  Volume: vol.6 Pages: 73-73
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21590515
[Patent] 国立大学法人鹿児島大学2022
- Inventor(s)
  兒玉大介、田中正和、久保田龍二、出雲周二
- Industrial Property Rights Holder
  兒玉大介、田中正和、久保田龍二、出雲周二
- Industrial Property Rights Type
  特許
- Filing Date
  2022
- Data Source
  KAKENHI-PROJECT-23K24380
[Presentation] HAM末梢血における自然免疫細胞の検討2023
- Author(s)
  堂園美香、久保田龍二、野妻智嗣、兒玉大介、田中正和、松浦英治、高嶋博
- Organizer
  第9回日本HTLV-1学会学術集会
- Data Source
  KAKENHI-PROJECT-23K24380
[Presentation] HAMにおけるPARPを介した神経細胞死の検討2023
- Author(s)
  田中正和、有島志保、野妻智嗣、松浦英治、高嶋博、三輪正直、久保田龍二
- Organizer
  第9回日本HTLV-1学会学術集会
- Data Source
  KAKENHI-PROJECT-23K24380
[Presentation] Illiopsoas muscle weakness as a key diagnositic marker in HTLV-1-associated myelopathy/tropical spastic paraparesis (HAM/TSP)2023
- Author(s)
  Matsuura E, Nozuma S, Dozono M, Yoshida Y, Kodama D, Tanaka M, Kubota R, Takashima H
- Organizer
  World Congress of Neurology 2023
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-23K24380
[Presentation] Involvement of LacNAc in HTLV-1 cell-to-cell contact infection and the discovery of its inhibitors.2023
- Author(s)
  兒玉大介、田中正和、松﨑敏男、野妻智嗣、松浦英治、高嶋博、出雲周二、久保田龍二
- Organizer
  第64回日本神経学会学術大会
- Data Source
  KAKENHI-PROJECT-23K24380
[Presentation] HTLV-1感染者血清はヒト内在性レトロウイルスHERV-K10に交叉応答する2023
- Author(s)
  兒玉大介、田中正和、松崎敏男、野妻智嗣、松浦英治、高嶋博、出雲周二、久保田龍二
- Organizer
  第9回日本HTLV-1学会
- Data Source
  KAKENHI-PROJECT-23K24380
[Presentation] 日本と台湾におけるHTLV-1ウイルスゲノム配列比較による分子疫学解析2023
- Author(s)
  野妻智嗣、堂園美香、吉田崇志、松浦英治、田中正和、兒玉大介、松崎敏男、吉村明子、Pai Shun-Chang、Chen Hung-Jen、Yang Ya-Chien、高嶋博、久保田龍二
- Organizer
  第9回日本HTLV-1学会学術集会
- Data Source
  KAKENHI-PROJECT-23K24380
[Presentation] HTLV-1感染によるPARPを介した神経細胞死の検討2022
- Author(s)
  田中正和、有島志保、野妻智嗣、松浦英治、高嶋博、三輪正直、出雲周二、久保田龍二
- Organizer
  第8回日本HTLV-1学術集会
- Data Source
  KAKENHI-PROJECT-23K24380
[Presentation] HAMにおけるPARP活性化を介した神経細胞死の検討2022
- Author(s)
  田中正和、有島志保、三輪正直、野妻智嗣、松浦英治、高嶋博、出雲周二、久保田龍二
- Organizer
  第26回日本神経感染症学会学術大会
- Data Source
  KAKENHI-PROJECT-23K24380
[Presentation] HTLV-1感染細胞を標的としたHAMでのバイオマーカー探索2022
- Author(s)
  野妻智嗣、松浦英治、堂園美香、田中正和、兒玉大介、松崎敏男、久保田龍二、高嶋博
- Organizer
  第26回日本神経感染症学会学術大会
- Data Source
  KAKENHI-PROJECT-23K24380
[Presentation] HTLV-1関連疾患における末梢血と気管支肺胞洗浄液中の感染細胞数の比較と肺胞移行能の検討2022
- Author(s)
  土元香菜子、森理紗、田中正和、兒玉大介、野妻智嗣、松浦英治、高嶋博、久保田龍二
- Organizer
  第26回日本神経感染症学会学術大会
- Data Source
  KAKENHI-PROJECT-23K24380
[Presentation] HAM/TSPの運動障害に対するL-アルギニンの効果を評価する第2相臨床試験（特定臨床研究）2022
- Author(s)
  松浦英治、野妻智嗣、田代雄一、安藤匡宏、平松有、樋口雄二郎、崎山雄介、橋口昭大、道園久美子、東桂子、松崎敏男、兒玉大介、田中正和、山野嘉久、久保田龍二、高嶋博
- Organizer
  第8回日本HTLV-1学術集会
- Data Source
  KAKENHI-PROJECT-23K24380
[Presentation] HAM患者の髄液での疾患特異的TCRレパトアの同定2022
- Author(s)
  野妻智嗣、堂園美香、松浦英治、田中正和、兒玉大介、松崎敏男、Steven Jacobson、久保田龍二、高嶋博
- Organizer
  第8回日本HTLV-1学術集会
- Data Source
  KAKENHI-PROJECT-23K24380
[Presentation] 細胞間接触感染に関与する二糖糖鎖LacNAcとcell-to-cell接触感染阻害薬の発見2022
- Author(s)
  兒玉大介、田中正和、松崎敏男、野妻智嗣、松浦英治、高嶋博、出雲周二、久保田龍二
- Organizer
  第8回日本HTLV-1学術集会
- Data Source
  KAKENHI-PROJECT-23K24380
[Presentation] HAM診断に適した髄液中抗HTLV-1抗体検査法2022
- Author(s)
  児玉大介、田中正和、久保田龍二
- Organizer
  第63回日本神経学会学術大会
- Data Source
  KAKENHI-PROJECT-23K24380
[Presentation] HTLV-1関連疾患別における肺胞移行能の検討2022
- Author(s)
  土元香菜子、田中正和、森理紗、兒玉大介、野妻智嗣、松浦英治、高嶋博、久保田龍二
- Organizer
  第8回日本HTLV-1学術集会
- Data Source
  KAKENHI-PROJECT-23K24380
[Presentation] 抗HTLV-1抗体髄液検査はCLIA法が適している2022
- Author(s)
  兒玉大介、田中正和、松崎敏男、野妻智嗣、松浦英治、高嶋博、出雲周二、久保田龍二
- Organizer
  第26回日本神経感染症学会学術大会
- Data Source
  KAKENHI-PROJECT-23K24380
[Presentation] 髄液中抗HTLV-1抗体検査とHAM診断2021
- Author(s)
  児玉大介、田中正和、松崎敏男、野妻智嗣、松浦英治、高嶋博、出雲周二、久保田龍二
- Organizer
  第7回日本HTLV-1学会学術集会
- Data Source
  KAKENHI-PROJECT-19K07999
[Presentation] Immunopathogenic CSF TCR repertoire signatures in virus-induced neurologic disease.2021
- Author(s)
  野妻智嗣、松浦英治、田中正和、久保田龍二、Steven Jacobson、高嶋博
- Organizer
  第62回日本神経学会学術大会
- Data Source
  KAKENHI-PROJECT-19K07999
[Presentation] HTLV-1感染細胞を標的としたTCRレパトア解析によるHAMの病勢指標となるバイオマーカーの探索2021
- Author(s)
  野妻智嗣、松浦英治、田中正和、松崎敏男、久保田龍二、高嶋博
- Organizer
  第7回日本HTLV-1学会学術集会
- Data Source
  KAKENHI-PROJECT-19K07999
[Presentation] HAM患者HTLV-1感染CD4+T細胞におけるTCRシグナルの低下2021
- Author(s)
  久保田龍二、田中正和、児玉大介、野妻智嗣、松浦英治、田中勇悦、高嶋博
- Organizer
  第7回日本HTLV-1学会学術集会
- Data Source
  KAKENHI-PROJECT-19K07999
[Presentation] HAM疾患活動性バイオマーカーとしてのCADM1の検討2021
- Author(s)
  竹之内徳博、田中正和、松浦英治、久保田龍二、中嶋伸介、大高時文、上野孝治、大隈和
- Organizer
  第7回日本HTLV-1学会学術集会
- Data Source
  KAKENHI-PROJECT-19K07999
[Presentation] Integrated mRNA and microRNA analysis of HTLV-1-infected cells from HAM patients.2021
- Author(s)
  久保田龍二、野妻智嗣、田中正和、松浦英治、高嶋博
- Organizer
  第62回日本神経学会学術大会
- Data Source
  KAKENHI-PROJECT-19K07999
[Presentation] Retrieval of therapeutic target molecules for HAM by microarray analysis of HTLV-1-infected cells.2020
- Author(s)
  久保田龍二、田中正和、松浦英治、高嶋　博
- Organizer
  第61回日本神経学会学術大会
- Data Source
  KAKENHI-PROJECT-19K07999
[Presentation] N-acetyllactosamine impacts on the infectivity of HTLV-1.2020
- Author(s)
  児玉大介、田中正和、出雲公子、松﨑敏男、松浦英治、高嶋博、出雲周二、久保田龍二
- Organizer
  第32回日本神経免疫学会学術集会
- Data Source
  KAKENHI-PROJECT-19K07999
[Presentation] High reactivity to anti-HERV-K10 in HTLV-1-infected individuals.2020
- Author(s)
  児玉大介、田中正和、松崎敏男、野妻智嗣、松浦英治、高嶋　博、出雲周二、久保田龍二
- Organizer
  第61回日本神経学会学術大会
- Data Source
  KAKENHI-PROJECT-19K07999
[Presentation] Immunopathogenic CSF TCR repertoire signatures in virus-associated neurologic disease.2020
- Author(s)
  野妻智嗣、松浦英治、田中正和、松崎敏男、久保田龍二、Steven Jacobson、高嶋　博
- Organizer
  第61回日本神経学会学術大会
- Data Source
  KAKENHI-PROJECT-19K07999
[Presentation] Inhibition of ABL1 induces decrease of proviral load HTLV-1 infected CD4+ T cell of HAM/TSP.2019
- Author(s)
  D. Kodama, M. Tanaka, T. Matsuzaki, H. Takashima, S. Izumo, R. Kubota.
- Organizer
  19th International Conference on Human Retrovirology: HTLV & Related Viruses,Lima, Peru.
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K07999
[Presentation] Suppression of HTLV-1 infection by lactoferrin.2019
- Author(s)
  M. Tanaka, N. Takenouchi, H. Tsuda, M. Miwa.
- Organizer
  52th Annual Meeting of the Society for Leukocyte Biology. Boston.
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K07999
[Presentation] HAM患者HTLV-1感染細胞のマイクロアレイ解析による治療標的分子の探索2019
- Author(s)
  久保田龍二、田中正和、春口志門、児玉大介、松浦英治、高嶋　博
- Organizer
  第6回日本HTLV-1学会,宮崎
- Data Source
  KAKENHI-PROJECT-19K07999
[Presentation] Microarray analysis reveals down-regulation of Toll-like receptor genes in activated HTLV-1-infected cells from patients with HTLV-1-associated neurological disease.2019
- Author(s)
  R. Kubota, M. Tanaka, D. Kodama, E. Matsuura, H. Takashima.
- Organizer
  52th Annual Meeting of the Society for Leukocyte Biology. Boston.
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K07999
[Presentation] Microarray analysis reveals down-regulation of Toll-like receptor genes in activated HTLV-1-infected cells from HAM/TSP patients.2019
- Author(s)
  R. Kubota, M. Tanaka, D. Kodama, E. Matsuura, H. Takashima.
- Organizer
  19th International Conference on Human Retrovirology: HTLV & Related Viruses,Lima, Peru.
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K07999
[Presentation] Effect of neuraminidase inhibitors on HTLV-1 infection and lymphocyte chemotaxis in HAM/TSP.2019
- Author(s)
  M. Tanaka, D. Kodama, E. Matsuura, H. Takashima, S. Izumo, R. Kubota.
- Organizer
  19th International Conference on Human Retrovirology: HTLV & Related Viruses,Lima, Peru.
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K07999
[Presentation] HTLV-1感染ヒト化マウスを用いた感染予防ワクチンにおけるアジュバント効果の検討2016
- Author(s)
  田中　正和, 任翊華, 竹之内　徳博, 姚　錦春, 李　成一, 藤澤　順一.
- Organizer
  第３回日本HTLV-1学会学術集会
- Place of Presentation
  鹿児島県市町村自治会館
- Year and Date
  2016-08-26
- Data Source
  KAKENHI-PROJECT-26430126
[Presentation] HTLV-1感染ヒト化マウスにおけるAPOBEC3Bの誘導について.2015
- Author(s)
  田中正和,姚錦春,李成一,任翊华,竹之内徳博,藤澤順一.
- Organizer
  第74回日本癌学会学術総会.
- Place of Presentation
  名古屋国際会議場・名古屋
- Year and Date
  2015-10-08
- Data Source
  KAKENHI-PROJECT-26430126
[Presentation] Induction of APOBEC3B cytidine deaminase gene in HTLV-1 infected T-cells of ATL model mouse.2015
- Author(s)
  Masakazu Tanaka, Jinchun Yao, Sung-il Lee, Yihua Ren, Norihiro Takenouchi, Jun-ichi Fujisawa.
- Organizer
  17th international conference on human retrovirology: HTLV & related viruses.
- Place of Presentation
  Martinique・France
- Year and Date
  2015-06-18
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26430126
[Presentation] HTLV-1感染ヒト化マウスモデルにおけるシチジンデアミナーゼAPOBEC3B遺伝子の活性化.2015
- Author(s)
  田中正和,姚錦春,李成一,任翊华,竹之内徳博,藤澤順一.
- Organizer
  第2回日本HTLV-1学会学術集会.
- Place of Presentation
  東京大学医科学研究所・東京
- Year and Date
  2015-08-21
- Data Source
  KAKENHI-PROJECT-26430126
[Presentation] 樹状細胞を介したHTLV-1感染モデルの構築と薬剤スクリーニングへの応用2014
- Author(s)
  竹之内徳博、上野孝治，荀潤澤，田中正和，藤澤順一
- Organizer
  第19回日本神経感染症学会総会学術集会
- Place of Presentation
  〒920-0993 石川県金沢市下本多町6番丁27 金沢歌劇座
- Year and Date
  2014-09-06
- Data Source
  KAKENHI-PROJECT-24591280
[Presentation] 樹状細胞を介したHTLV-1感染モデルの構築2014
- Author(s)
  竹之内徳博、上野孝治，手塚健太，田中正和、藤澤順一
- Organizer
  第55回日本神経学会学術大会
- Place of Presentation
  〒812-0032 福岡県福岡市博多区石城町２−１　福岡国際会議場
- Year and Date
  2014-05-23
- Data Source
  KAKENHI-PROJECT-24591280
[Presentation] 樹状細胞を介したin vitro HTLV-1感染モデルの構築2013
- Author(s)
  竹之内徳博、上野孝治、手塚健太、田中正和、藤澤順一
- Organizer
  第25回日本神経免疫学会集会
- Place of Presentation
  海峡メッセ下関（山口）
- Data Source
  KAKENHI-PROJECT-24591280
[Presentation] IBMI-ヒト化マウスを用いたHTLV-1感染マウスモデル2012
- Author(s)
  手塚健太、上野孝治、鄭　真美、荀潤澤、田中正和、竹之内徳博、藤澤順一
- Organizer
  第５回HTLV-1研究会/シンポジウム
- Place of Presentation
  東京、東京大学医科学研究所講堂
- Data Source
  KAKENHI-PROJECT-24591280
[Presentation] HTLV-1感染ヒト化マウスにおける欠損型プロウイルスの解析2011
- Author(s)
  手塚健太、上野孝治、荀潤澤、竹之内徳博、田中正和、藤澤順一
- Organizer
  第70回日本癌学会学術総会
- Place of Presentation
  名古屋
- Year and Date
  2011-10-05
- Data Source
  KAKENHI-PROJECT-21590515
[Presentation] Anti-tumor effects of bovine lactoferrin to lymphoma cells expressing HTLV-1 Tax2011
- Author(s)
  田中正和
- Organizer
  第70回日本癌学会学術総会
- Place of Presentation
  名古屋国際会議場(名古屋)
- Year and Date
  2011-10-05
- Data Source
  KAKENHI-PROJECT-21590515
[Presentation] Infection of defective virus correlated with the induction of CD25 positive CD4 T-cell during early phase of infection in humanized mouse model2011
- Author(s)
  Takaharu Ueno, Kenta Tezuka, Runze Xun, Mami Tei, Masakazu Tanaka, Norihiro Takenouchi, Jun-ichi Fujisawa
- Organizer
  The XV International Congress of Virology
- Place of Presentation
  札幌
- Year and Date
  2011-09-12
- Data Source
  KAKENHI-PROJECT-21590515
[Presentation] Inverse correlation between Tax anda CD25 expressions in HTLV-1 infected CD4 T-cells in vivo2011
- Author(s)
  Kenta Tezuka, Runze Xun, Mami Tei, Takaharu Ueno, Masakazu Tanaka, Norihiro Takenouchi, Jun-ichi Fujisawa
- Organizer
  15th International conference on human retorovirology HTLV and related viruses
- Place of Presentation
  Leuven/Gembloux Belgium
- Year and Date
  2011-06-05
- Data Source
  KAKENHI-PROJECT-21590515
[Presentation] ATL-like overgrowth and clonal expansion of HTLV-1 infected CD25+CD4+T-lymphocyte in humanized-NOG mouse model2011
- Author(s)
  Jun-ichi Fujisawa, Kenta Tezuka, Runze Xun, Mami Tei, Norihiro Takenouchi, Masakazu Tanaka
- Organizer
  15th International conference on human retorovirology HTLV and related viruses
- Place of Presentation
  Leuven/Gembloux Belgium
- Year and Date
  2011-06-05
- Data Source
  KAKENHI-PROJECT-21590515
[Presentation] Inverse correlation between tax and CD25 expressions in HTLV-1 infected CD4+T-cells in vivo2011
- Author(s)
  Kenta Tezuka, Runze Xun, Mami Tei, Takaharu Ueno, Masakazu Tanaka, Norihiro Takenouchi, Jun-ichi Fujisawa
- Organizer
  The XV International Congress of Virology
- Place of Presentation
  札幌
- Year and Date
  2011-09-13
- Data Source
  KAKENHI-PROJECT-21590515
[Presentation] Anti-tumor effects of bovine lactoferrin to lymphoma cells expressing HTLV-1 Tax2011
- Author(s)
  Masakazu Tanaka, Naoki Wada, Iwao Hashimoto, Sho Hasegawa, Hiroyuki Tsuda, Masanao Miwa, Jun-ichi Fujisawa
- Organizer
  第70回日本癌学会学術総会
- Place of Presentation
  名古屋
- Year and Date
  2011-10-05
- Data Source
  KAKENHI-PROJECT-21590515
[Presentation] Immunotherapy for tumors using combination of allogenic intra-bone-marrow bone-marrow transplantation(IBM-BMT) and donor lymphocyte infusion(DLI) in EL4/Gax implanted mouse2010
- Author(s)
  Tanaka M, Hasegawa S, Hashimoto I, Adachi Y, Ikehara S, Miwa M, Fujisawa J
- Organizer
  第69回日本癌学会学術総会
- Place of Presentation
  大阪
- Year and Date
  2010-09-22
- Data Source
  KAKENHI-PROJECT-21590515
[Presentation] Immunotherapy for tumors using combination of allogenic intra-bone-marrow bone-marrow transplantation (IBM-BMT) and donor lymphocyte infusion (DLI) in EL4/Gax implanted mouse.2010
- Author(s)
  田中正和
- Organizer
  第69回日本癌学会学術総会
- Place of Presentation
  大阪国際会議場(大阪)
- Year and Date
  2010-09-22
- Data Source
  KAKENHI-PROJECT-21590515
[Presentation] HTLV-1感染ヒト化マウスを用いた感染T細胞選択過程の解析2010
- Author(s)
  田中正和
- Organizer
  第58回日本ウイルス学会学術集会
- Place of Presentation
  徳島県郷土文化会館(徳島)
- Year and Date
  2010-11-08
- Data Source
  KAKENHI-PROJECT-21590515
[Presentation] HTLV-1感染ヒト化マウスを用いた感染T細胞選択過程の解析2010
- Author(s)
  田中正和, 荀潤澤, 手塚健太, 三輪正直, 竹之内徳博, 藤澤順一
- Organizer
  第58回日本ウイルス学会学術集会
- Place of Presentation
  徳島
- Year and Date
  2010-11-08
- Data Source
  KAKENHI-PROJECT-21590515
[Presentation] ヒト化マウスモデルにおけるHTLV-1感染CD25+T細胞のクローナル増殖2009
- Author(s)
  手塚健太, 荀潤澤, 田中正和, 三輪正直, 竹之内徳博, 藤澤順一
- Organizer
  第57回日本ウイルス学会学術集会
- Place of Presentation
  東京
- Year and Date
  2009-10-27
- Data Source
  KAKENHI-PROJECT-21590515
[Presentation] Clonal expansion of HTLV-1 infected CD25^+ CD^4+T^- cells and the expression of Tax-specific CTLs in humanized mouse model2009
- Author(s)
  田中正和
- Organizer
  第68回日本癌学会学術総会
- Place of Presentation
  パシフィコ横浜(横浜)
- Year and Date
  2009-10-02
- Data Source
  KAKENHI-PROJECT-21590515
[Presentation] マウスモデルを用いた骨髄移植/リンパ球輸注による抗ATL治療法の検討2009
- Author(s)
  長谷川翔, 橋本岩雄, 田中正和, 足立靖, 池原進, 三輪正直, 藤澤順一
- Organizer
  第57回日本ウイルス学会学術集会
- Place of Presentation
  東京
- Year and Date
  2009-10-26
- Data Source
  KAKENHI-PROJECT-21590515
[Presentation] ヒト化マウスモデルにおけるHTLV-1感染CD4CD25陽性T細胞のクローナル増殖性とTax特異的なCTL検出について2009
- Author(s)
  田中正和, 荀潤澤, 手塚健太, 巽理恵, 竹之内徳博, 三輪正直, 藤澤順一
- Organizer
  第68回日本癌学会学術総会
- Place of Presentation
  横浜
- Year and Date
  2009-10-02
- Data Source
  KAKENHI-PROJECT-21590515
[Presentation] HTLV-1感染ヒト化マウスT細胞におけるCD25の活性化2009
- Author(s)
  荀潤澤, 手塚健太, 田中正和, 三輪正直, 竹之内徳博, 藤澤順一
- Organizer
  第57回日本ウイルス学会学術集会
- Place of Presentation
  東京
- Year and Date
  2009-10-27
- Data Source
  KAKENHI-PROJECT-21590515

1. TAKUNOUCHI Norihiro (20533235)

# of Collaborated Projects: 2 results

# of Collaborated Products: 14 results
2. Kubota Ryuji (70336337)

# of Collaborated Projects: 2 results

# of Collaborated Products: 34 results
3. FUJISAWA Jun-ichi (40181341)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
4. 松浦英治 (30598800)

# of Collaborated Projects: 1 results

# of Collaborated Products: 22 results
5. Yao Jinchun

# of Collaborated Projects: 1 results

# of Collaborated Products: 4 results
6. 藤沢順一

# of Collaborated Projects: 0 results

# of Collaborated Products: 22 results
7. 東貞行

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
8. 山口宗一

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
9. 橋口照人

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
10. 高嶋博

# of Collaborated Projects: 0 results

# of Collaborated Products: 6 results

TANAKA Masakazu 田中 正和

Research Projects

Research Products

Co-Researchers

Pathogenesis of HTLV-1-associated myelopathy (HAM) by innate immune analysis and development of new treatment methods

Principal Investigator

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Research Institution

Development of a new treatment for HAM/TSP targeting HTLV-1-infected cells

Principal Investigator

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Review Section

Research Institution

Elucidation of the gene variation accumulation mechanism in the tumor developmental process using HTLV -1 humanized mousePrincipal Investigator

Principal Investigator

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Research Institution

Establishment of HTLV-1 infection model via dendritic cells and the use to screening of medicines.

Principal Investigator

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Research Institution

Study of mechanism for the development of ATL and HAM by using HTLV-1 infected humanized mouse model

Principal Investigator

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Research Institution

[Journal Article] Geographic characteristics of HTLV-1 molecular subgroups and genetic substitutions in East Asia: Insights from complete genome sequencing of HTLV-1 strains isolated in Taiwan and Japan2024

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Anti-ganglionic acetylcholine receptor antibodies in functional neurological symptom disorder/conversion disorder2023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Identification and tracking of HTLV-1-infected T cell clones in virus-associated neurologic disease2023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Iliopsoas Muscle Weakness as a Key Diagnostic Marker in HTLV-1-Associated Myelopathy/Tropical Spastic Paraparesis (HAM/TSP)2023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Efficacy of L-Arginine Treatment in Patients with HTLV-1-Associated Neurological Disease.2023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] HTLV-1-associated myelopathy/tropical spastic paraplegia with sporadic late-onset nemaline myopathy: a case report2023

Author(s)

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DOI

Data Source

[Journal Article] High Prevalence of HTLV-1 Carriers Among the Elderly Population in Kagoshima, a Highly Endemic Area in Japan2022

Author(s)

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DOI

Data Source

[Journal Article] Anti-human T-cell leukemia virus type 1 (HTLV-1) antibody assays in cerebrospinal fluid for the diagnosis of HTLV-1-associated myelopathy/tropical spastic paraparesis2021

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Inhibition of ABL1 tyrosine kinase reduces HTLV-1 proviral loads in peripheral blood mononuclear cells from patients with HTLV-1-associated myelopathy/tropical spastic paraparesis2020

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Expression of TSLC1 in patients with HAM/TSP2020

TANAKA Masakazu 田中正和