MATSUDA Daisuke 松田大介

Researcher Number	20458764
Affiliation (based on the past Project Information) *help	2008 – 2009: Kitasato University, 薬学部, 助教
Review Section/Research Field	Principal Investigator Living organism molecular science
Keywords	Principal Investigator 天然由来阻害剤 / 脂質代謝 / 動脈硬化症 / ケミカルバイオロジー

Research Projects
(1 results)
Research Products
(41 results)

Study on the action mechanism of inhibition of natural origin on lipid droplet formation in macrophages.Principal Investigator
- Principal Investigator
  
  MATSUDA Daisuke
- Project Period (FY)
  2008 – 2009
- Research Category
  
  Grant-in-Aid for Young Scientists (Start-up)
- Research Field
  
  Living organism molecular science
- Research Institution
  Kitasato University

All 2010 2009 2008 Other

All Journal Article Presentation

[Journal Article] 脂質異常症治療薬2010
- Author(s)
  松田大介、供田洋
- Journal Title
  
  医薬ジャーナル新薬展望 46S-1
  
  Pages: 477-480
- Data Source
  KAKENHI-PROJECT-20810028
[Journal Article] スタチンを超える薬物療法の可能性2009
- Author(s)
  松田大介、大城太一、供田洋
- Journal Title
  
  内科 103
  
  Pages: 137-140
- Data Source
  KAKENHI-PROJECT-20810028
[Journal Article] The molecular target of rubimaillin in the inhibition of lipid droplet accumulation in macrophages.2009
- Author(s)
  D. Matsuda, T. Ohshiro, M. Ohba, W. Jiang, B. Hong, S. Si, H. Tomoda
- Journal Title
  
  Biol. Pharm. Bull 32
  
  Pages: 1317-1320
- NAID
  130000117241
- Data Source
  KAKENHI-PROJECT-20810028
[Journal Article] The Selectivity of beauveriolide derivatives in inhibition toward the two isozymes of acyl-CoA:cholesterol acyltransferase.2009
- Author(s)
  T. Ohshiro, D. Matsuda, K. Nagai, T. Doi, T. Sunazuka, T. Takahashi, L.L. Rudel, S. Omura, H. Tomoda
- Journal Title
  
  Chem. Pharm. Bull 57
  
  Pages: 377-381
- Data Source
  KAKENHI-PROJECT-20810028
[Journal Article] The molecular target of rubimaillin in the inhibition of lipid droplet accumulation in macrophages.2009
- Author(s)
  D.Matsuda, et al.
- Journal Title
  
  Biol.Pharm.Biol. 32
  
  Pages: 1317-1320
- NAID
  130000117241
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20810028
[Journal Article] スタチンを超える薬物療法の可能性2009
- Author(s)
  松田大介, 大城太一, 供田洋
- Journal Title
  
  内科 103
  
  Pages: 137-140
- Data Source
  KAKENHI-PROJECT-20810028
[Journal Article] Application of a 3, 3-diphenylpentane skeleton as a multi-template for creation of HMG-CoA reductase inhibitors.2009
- Author(s)
  S. Hosoda, D. Matsuda, H. Tomoda, M. Hashimoto, H. Aoyama, Y. Hashimoto
- Journal Title
  
  Bioorg. Med. Chem. Lett 19
  
  Pages: 4228-4231
- Data Source
  KAKENHI-PROJECT-20810028
[Journal Article] Pentacecilides, new inhibitors of lipid droplet formation in mouse macrophages, produced by Penicillium cecidicola FKI-3765-1: I. Taxonomy, fermentation, isolation and biological properties.2009
- Author(s)
  H. Yamazaki, K. Kobayashi, D. Matsuda, K. Nonaka, R. Masuma, S. Omura H. Tomoda
- Journal Title
  
  J. Antibiot 62
  
  Pages: 195-200
- NAID
  10030635010
- Data Source
  KAKENHI-PROJECT-20810028
[Journal Article] Diphenylpentane skeleton as a multi-template for steroid skeleton-recognizing receptors/enzymes.2009
- Author(s)
  S. Hosoda, D. Matsuda, H. Tomoda, Y. Hashimoto
- Journal Title
  
  Mini Rev. Med. Chem 9
  
  Pages: 572-580
- Data Source
  KAKENHI-PROJECT-20810028
[Journal Article] Anti-atherosclerotic activity of triacsin C, an acyl-CoA synthetase inhibitor.2008
- Author(s)
  D. Matsuda, et al.
- Journal Title
  
  J. Antibiot. 61
  
  Pages: 318-321
- NAID
  10021927833
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20810028
[Journal Article] Molecular target of piperine in the inhibition of lipid droplet accumulation in macrophages.2008
- Author(s)
  D. Matsuda, et al.
- Journal Title
  
  Biol. Pharm. Bull. 31
  
  Pages: 1063-1068
- NAID
  110006684316
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20810028
[Journal Article] Absolute stereochemistry of pentacecilides, new inhibitors of lipid droplet formation in mouse macrophages, produced by Penicillium cecidicola FKI-3765-1
- Author(s)
  H. Yamazaki, N. Ugaki, D. Matsuda, H. Tomoda
- Journal Title
  
  J. Antibiot (in press)
- NAID
  10030708654
- Data Source
  KAKENHI-PROJECT-20810028
[Presentation] 微生物資源からの医薬品開発への挑戦2010
- Author(s)
  松田大介、供田洋
- Organizer
  第10回次世代医療システム産業化フォーラム2009
- Place of Presentation
  神戸
- Year and Date
  2010-01-26
- Data Source
  KAKENHI-PROJECT-20810028
[Presentation] ACAT2選択的阻害剤pyripyropene Aの誘導体合成と構造活性相関2010
- Author(s)
  大多和正樹、福永恵子、山崎寛之、松田大介、大城太一、針谷義弘、長光亨、大村智、供田洋
- Organizer
  日本薬学会第130年回年会
- Place of Presentation
  岡山
- Data Source
  KAKENHI-PROJECT-20810028
[Presentation] 生活習慣病や感染症の治療に有効な標的分子に対する評価系の構築と天然資源および化合物ライブラリーの構築2009
- Author(s)
  供田洋、猪腰淳嗣、内田龍児、小山信裕、松田大介
- Organizer
  第26回白金シンポジウム
- Place of Presentation
  東京
- Data Source
  KAKENHI-PROJECT-20810028
[Presentation] Pyripyropene A, a selective inhibitor of acyl-CoA:cholesterol acyltransferase 2, attenuate hypercholesterolemia and atherosclerosis in atherogenic mice2009
- Author(s)
  T. Ohshiro, D. Matsuda, K. Sakai, C. Degirolamo, H. Yagyu, L.L. Rudel, S. Omura, S. Ishibahi, H. Tomoda
- Organizer
  11th International Conference on the Chemistry of Antibiotics and Other Bioactive Compounds
- Place of Presentation
  San Sebastian, Spain
- Data Source
  KAKENHI-PROJECT-20810028
[Presentation] 天然由来DGAT阻害剤のアイソザイム選択性に関する研究2009
- Author(s)
  川本恭佑、猪腰淳嗣、高木陽一、松田大介、松濱万貴、大村智、供田洋
- Organizer
  日本薬学会第129年回年会
- Place of Presentation
  京都
- Data Source
  KAKENHI-PROJECT-20810028
[Presentation] 真菌由来beauveroilide IIIのACAT1選択的阻害活性に関する研究2009
- Author(s)
  大場未央、松田大介、大城太一、土井隆行、高橋孝志、大村智、供田洋
- Organizer
  日本薬学会第129年回年会
- Place of Presentation
  京都
- Data Source
  KAKENHI-PROJECT-20810028
[Presentation] 真菌FKI-3765-1株が生産する新規マクロファージ内脂肪滴蓄積阻害物質の研究2009
- Author(s)
  山崎寛之、小林翔、松田大介、野中健一、増間碌朗、大村智、供田洋
- Organizer
  日本薬学会第129年回年会
- Place of Presentation
  京都
- Data Source
  KAKENHI-PROJECT-20810028
[Presentation] The inhibition mechanism of bleomycin-induced G2 arrest by pycnidione.2009
- Author(s)
  D.Matsuda, et al.
- Organizer
  The 25^<th> Naito Conference
- Place of Presentation
  Sapporo
- Year and Date
  2009-09-10
- Data Source
  KAKENHI-PROJECT-20810028
[Presentation] マクロファージ内脂肪滴蓄積阻害剤beauveroilide IIIの作用様式の解析2009
- Author(s)
  大場未央、松田大介、大城太一、土井隆行、高橋孝志、大村智、供田洋
- Organizer
  第22回バイオサイエンスフォーラム
- Place of Presentation
  東京
- Data Source
  KAKENHI-PROJECT-20810028
[Presentation] ACAT2選択的阻害剤ピリピロペンAの抗動脈硬化作用2009
- Author(s)
  坂井謙斗、大城太一、松田大介、野牛宏晃、Lawrence Rudel、大村智、石橋俊、供田洋
- Organizer
  日本薬学会第129年回年会
- Place of Presentation
  京都
- Data Source
  KAKENHI-PROJECT-20810028
[Presentation] The inhibition mechanism of bleomycin-induced G2 arrest by pycnidione2009
- Author(s)
  D. Matsuda, M. Kaneko, S. Yokota, H. Tomoda
- Organizer
  The 25th Naito Conference
- Place of Presentation
  Sapporo
- Data Source
  KAKENHI-PROJECT-20810028
[Presentation] DNA傷害性シグナル伝達を阻害するpycnidioneの作用機構に関する研究2009
- Author(s)
  金子真弓、松田大介、大多和正樹、内田龍児、長光亨、針谷義弘、大村智、供田洋
- Organizer
  日本薬学会第129年回年会
- Place of Presentation
  京都
- Data Source
  KAKENHI-PROJECT-20810028
[Presentation] ピクニジオンによるトポイソメラーゼIIの阻害はブレオマイシンにより引き起こされるG2期修復機構を解除する2009
- Author(s)
  松田大介、金子真弓、横田紗弥香、矢守隆夫、供田洋
- Organizer
  第32回日本分子生物学会年会
- Place of Presentation
  横浜
- Data Source
  KAKENHI-PROJECT-20810028
[Presentation] ACAT2選択的阻害剤pyripyropene Aの誘導体合成と構造活性相関2009
- Author(s)
  大多和正樹、山崎寛之、松田大介、大城太一、針谷義弘、長光亨、大村智、供田洋
- Organizer
  第28回メディシナルケミストリーシンポジウム
- Place of Presentation
  東京
- Data Source
  KAKENHI-PROJECT-20810028
[Presentation] ACAT2選択的阻害剤pyripyropene Aの誘導体合成と構造活性相関2009
- Author(s)
  大多和正樹、山崎寛之、松田大介、大城太一、針谷義弘、長光亨、大村智、供田洋
- Organizer
  日本薬学会第129年回年会
- Place of Presentation
  京都
- Data Source
  KAKENHI-PROJECT-20810028
[Presentation] Pyripyropene A, a selective inhibitor of acyl-CoA:cholesterol acyltransferase 2, attenuates hypercholesterolemia and atherosclerosis in apolipoprotein E knockout mice2009
- Author(s)
  T. Ohshiro, K. Sakai, D. Matsuda, M. Ohtawa, T. Nagamitsu, H. Yagyu, L.L. Rudel, S. Omura, S. Ishibashi, H. Tomoda
- Organizer
  第41年日本動脈硬化学会総会・学術集会
- Place of Presentation
  下関
- Data Source
  KAKENHI-PROJECT-20810028
[Presentation] マクロファージ内脂肪滴蓄積阻害剤beauveriolideの標的分子の解析2008
- Author(s)
  松田大介、大城太一、土井隆行、大場未央、高橋孝志、大村智、供田洋
- Organizer
  第31回日本分子生物学会年会第81回日本生化学会大会合同大会
- Place of Presentation
  神戸
- Data Source
  KAKENHI-PROJECT-20810028
[Presentation] Dinapinones, novel inhibitor of triacylglycerol synthesis in CHO-K1 cells produced by Penicillium pinophilum FKI-38642008
- Author(s)
  S. Ohte, R. Uchida, D. Matsuda, K. Nonaka, R. Masuma, S. Omura, H. Tomoda
- Organizer
  The 4th Korea-Japan Joint Symposium Chemical Biology for Bioactive Molecules
- Place of Presentation
  Kinugawa, Tochigi, Japan
- Data Source
  KAKENHI-PROJECT-20810028
[Presentation] ステロイド代替骨格であるジフェニルペンタン誘導体の創製:核内受容体リガンドとHMG-CoA還元酵素阻害剤2008
- Author(s)
  細田信之介、松田大介、供田洋、橋本祐一
- Organizer
  第27回メディシナルケミストリーシンポジウム
- Place of Presentation
  大阪
- Data Source
  KAKENHI-PROJECT-20810028
[Presentation] 天然由来DGAT阻害剤のアイソザイム選択性2008
- Author(s)
  川本恭佑、猪腰淳嗣、高木陽一、大手聡、松田大介、松濱万貴、供田洋
- Organizer
  第21回バイオサイエンスフォーラム
- Place of Presentation
  相模原
- Data Source
  KAKENHI-PROJECT-20810028
[Presentation] Dinapinones, novel inhibitors of triacylglycerol synthesis in CHO-K1 cells produced by Penicillium pinophilum FKI-38642008
- Author(s)
  R. Uchida, S. Ohte, D. Matsuda, K. Nonaka, R. Masuma, S. Omura H. Tomoda
- Organizer
  SIM Annual Meeting and Exhibition
- Place of Presentation
  San Diego, USA
- Data Source
  KAKENHI-PROJECT-20810028
[Presentation] キサントン誘導体による脂肪滴蓄積阻害活性はacetyl-CoA carb oxylaseの阻害によるのだろうか?2008
- Author(s)
  松田大介, 他
- Organizer
  第50回日本薬脂質生化学会
- Place of Presentation
  徳島
- Year and Date
  2008-06-05
- Data Source
  KAKENHI-PROJECT-20810028
[Presentation] キサントン誘導体による脂肪滴蓄積阻害活性はacetyl-CoA carboxylaseの阻害によるのだろうか?2008
- Author(s)
  松田大介、小林翔、深澤征義、西島正弘、花田賢太郎、司書毅、供田洋
- Organizer
  第50回日本薬脂質生化学会
- Place of Presentation
  徳島
- Data Source
  KAKENHI-PROJECT-20810028
[Presentation] 天然由来DGAT阻害剤のアイソザイム選択性2008
- Author(s)
  猪腰淳嗣、高木陽一、大手聡、松田大介、川本恭佑、松濱万貴、供田洋
- Organizer
  第50回日本薬脂質生化学会
- Place of Presentation
  徳島
- Data Source
  KAKENHI-PROJECT-20810028
[Presentation] G2期修復機構阻害物質pycnidione作用機序の解析2008
- Author(s)
  金子真弓、松田大介、内田龍児、大村智、供田洋
- Organizer
  第31回日本分子生物学会年会第81回日本生化学会大会合同大会
- Place of Presentation
  神戸
- Data Source
  KAKENHI-PROJECT-20810028
[Presentation] ACAT2選択的阻害剤pyripyropene Aの誘導体合成と構造活性相関2008
- Author(s)
  大多和正樹、山崎寛之、松田大介、大城太一、針谷義宏、長光亨、大村智、供田洋
- Organizer
  第27回メディシナルケミストリーシンポジウム
- Place of Presentation
  大阪
- Data Source
  KAKENHI-PROJECT-20810028
[Presentation] Suppression of lipid droplet accumulation in mouse peritoneal macrophages by piperine.2008
- Author(s)
  D. Matsuda, et al.
- Organizer
  The 4^<th> Korea-Japan Joint Symposium Chemical Biology for Bioactive Molecules
- Place of Presentation
  Kinugavva, Tochigi, Japan
- Year and Date
  2008-05-21
- Data Source
  KAKENHI-PROJECT-20810028
[Presentation] マクロファージ内脂肪滴蓄積阻害活性を示すツルリンドウ由来成分の作用機序の解析2008
- Author(s)
  松田大介、小林翔、深澤征義、西島正弘、花田賢太郎、司書毅、供田洋
- Organizer
  第21回バイオサイエンスフォーラム
- Place of Presentation
  相模原
- Data Source
  KAKENHI-PROJECT-20810028
[Presentation] Suppression of lipid droplet accumulation in mouse peritoneal macrophages by piperine2008
- Author(s)
  D. Matsuda, S. Ohte, T. Ohshiro, W. Jiang, L.L. Rudel, B. Hong, S. Si, H. Tomoda
- Organizer
  The 4th Korea-Japan Joint Symposium Chemical Biology for Bioactive Molecules
- Place of Presentation
  Kinugawa, Tochigi, Japan
- Data Source
  KAKENHI-PROJECT-20810028

MATSUDA Daisuke 松田 大介

Research Projects

Research Products

Study on the action mechanism of inhibition of natural origin on lipid droplet formation in macrophages.Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] 脂質異常症治療薬2010

Author(s)

Journal Title

Data Source

[Journal Article] スタチンを超える薬物療法の可能性2009

Author(s)

Journal Title

Data Source

[Journal Article] The molecular target of rubimaillin in the inhibition of lipid droplet accumulation in macrophages.2009

Author(s)

Journal Title

NAID

Data Source

[Journal Article] The Selectivity of beauveriolide derivatives in inhibition toward the two isozymes of acyl-CoA:cholesterol acyltransferase.2009

Author(s)

Journal Title

Data Source

[Journal Article] The molecular target of rubimaillin in the inhibition of lipid droplet accumulation in macrophages.2009

Author(s)

Journal Title

NAID

Data Source

[Journal Article] スタチンを超える薬物療法の可能性2009

Author(s)

Journal Title

Data Source

[Journal Article] Application of a 3, 3-diphenylpentane skeleton as a multi-template for creation of HMG-CoA reductase inhibitors.2009

Author(s)

Journal Title

Data Source

[Journal Article] Pentacecilides, new inhibitors of lipid droplet formation in mouse macrophages, produced by Penicillium cecidicola FKI-3765-1: I. Taxonomy, fermentation, isolation and biological properties.2009

Author(s)

Journal Title

NAID

Data Source

[Journal Article] Diphenylpentane skeleton as a multi-template for steroid skeleton-recognizing receptors/enzymes.2009

Author(s)

Journal Title

Data Source

[Journal Article] Anti-atherosclerotic activity of triacsin C, an acyl-CoA synthetase inhibitor.2008

Author(s)

Journal Title

NAID

Data Source

[Journal Article] Molecular target of piperine in the inhibition of lipid droplet accumulation in macrophages.2008

Author(s)

Journal Title

NAID

Data Source

[Journal Article] Absolute stereochemistry of pentacecilides, new inhibitors of lipid droplet formation in mouse macrophages, produced by Penicillium cecidicola FKI-3765-1

Author(s)

Journal Title

NAID

Data Source

[Presentation] 微生物資源からの医薬品開発への挑戦2010

Author(s)

Organizer

Place of Presentation

Year and Date

Data Source

[Presentation] ACAT2選択的阻害剤pyripyropene Aの誘導体合成と構造活性相関2010

Author(s)

Organizer

Place of Presentation

Data Source

[Presentation] 生活習慣病や感染症の治療に有効な標的分子に対する評価系の構築と天然資源および化合物ライブラリーの構築2009

Author(s)

Organizer

Place of Presentation

Data Source

[Presentation] Pyripyropene A, a selective inhibitor of acyl-CoA:cholesterol acyltransferase 2, attenuate hypercholesterolemia and atherosclerosis in atherogenic mice2009

MATSUDA Daisuke 松田大介