OKI HIROHARU 大木弘治

… Alternative Names

大木弘治オオキヒロハル

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Researcher Number	20463812
Affiliation (Current)	2025: 山形大学, 医学部, 助教
Affiliation (based on the past Project Information) *help	2020: 山形大学, 医学部, 客員研究員 2018 – 2019: 山形大学, 医学部, 非常勤講師 2017: 山形大学, 医学部, 助教
Review Section/Research Field	Except Principal Investigator Basic Section 56020:Orthopedics-related / Orthopaedic surgery
Keywords	Except Principal Investigator 自然免疫 / 関節リウマチ / インプラント感染症 / 生体反応 / 感染 / インプラント感染 / 選択的オートファジー / 自然免疫受容体 / 人工関節インプラント感染症 / 変形性関節症 … More / 人工関節 / 炎症性滑膜組織 / オートファジー / 人工関節周囲感染 / 薬剤反応性 / 免疫学 / 薬剤抵抗性 / グレード分類 / 疾患活動性 / 炎症性サイトカイン / 炎症性免疫担当細胞 / 獲得免疫 / 制御性免疫 / Toll様受容体 / 薬剤耐性 Less

Innate immune receptor and alternative autophagy in pathogenesis of prosthetic joint infection
- Principal Investigator
  
  Takagi Michiaki
- Project Period (FY)
  2018 – 2020
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 56020:Orthopedics-related
- Research Institution
  Yamagata University
The role of innate immunology in the patients with early rheumatoid arthritis and resistant-anti rheumatic drugs
- Principal Investigator
  
  Takakubo Yuya
- Project Period (FY)
  2017 – 2019
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Orthopaedic surgery
- Research Institution
  Yamagata University

All 2019 2018

All Journal Article Presentation

[Journal Article] 生物学的製剤使用関節リウマチ患者における整形外科手術の検討.2019
- Author(s)
  高窪祐弥, 大木弘治, 長沼靖、梁秀蘭、高木理彰
- Journal Title
  
  関節の外科
  
  Volume: 45 Pages: 101-104
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17K10995
[Journal Article] Disassembly of bilateral bipolar heads within 10 years after hip hemiarthroplasties for avascular necrosis of femoral heads: a case report.2019
- Author(s)
  Ito J, Takakubo Y, Monma R, Oki H, Sasaki K, Takagi M
- Journal Title
  
  Modern Rheumatology Case Reports.
  
  Volume: 4 Issue: 1 Pages: 147-151
- DOI
  10.1080/24725625.2019.1662596
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18H02917, KAKENHI-PROJECT-17K10995
[Journal Article] Rapid disappearing of gouty tophi of foot due to reducing urate pool by resection of huge gouty tophi of opposite foot in the patient with hyperuricemia; a case of report.2019
- Author(s)
  Takakubo Y, Imamura Y, Tezuka H, Okada S, Naganuma Y, Ito J, Sugawara M, Yang S, Oki H, Sasaki A, Sasaki K, Takagi M
- Journal Title
  
  Modern Rheumatology Case Reports
  
  Volume: 4 Issue: 1 Pages: 1-6
- DOI
  10.1080/24725625.2019.1680135
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18H02917, KAKENHI-PROJECT-17K10995
[Presentation] Anti-tumor necrosis factor agents influence the apoptosis of inflammatory synovial cells in the patients with rheumatoid arthritis.2019
- Author(s)
  Takakubo Y, Suzuki Y, Yang S, Oki H, Takagi M
- Organizer
  The 2nd International Combined Meeting of Orthopaedic Reserch Societies
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K10995
[Presentation] Distrbution of Toll-like receptors expressing immune-cells in rheumatoid synovial tissues of the patients who received CTLA4-Ig agent.2019
- Author(s)
  1.Takakubo Y, Oki H, Yang S, Sasaki A, Sasaki K, Naganuma Y, KatoY, Takagi M
- Organizer
  ORS 2019 Annual Meeting
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K10995
[Presentation] Comparison of clinical features between subtrochanteric and diaphyseal atypical femoral fractures in our super-aging area.2019
- Author(s)
  Miyaji T, Takakubo Y, Ota D, Shibuya J, Oki H, Ito J, Sasaki K**, Takagi M
- Organizer
  The 92nd Annual Meeting of the Japanese Orthopaedic Association
- Data Source
  KAKENHI-PROJECT-18H02917
[Presentation] A Novel Monoclonal Antibody SMab-2 Recognizes Endogenous IDH2-R172S of Chondrosarcoma.2019
- Author(s)
  Liu X, Oki H, Takagi M
- Organizer
  The 2nd International Combined Meeting of Orthopaedic Reserch Societies
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18H02917
[Presentation] Utility of alpha-defesin lateral flow device for periprosthetic joint onfection and septic arthritis.2019
- Author(s)
  Narita A, Suzuki A, Nakajima, Takakubo Y, Ito J, Yuki I, Oki H, Naganuma Y, Takagi M
- Organizer
  ORS 2019 Annual Meeting
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K10995
[Presentation] The trend of revision total hip arthroplasties in super-aging area in last fourteen years.2019
- Author(s)
  Takakubo Y, Ito J, Oki H**, Momma R, Sasaki K**, Kawaji H**, Ishi M**, Takagi M
- Organizer
  The 92nd Annual Meeting of the Japanese Orthopaedic Association
- Data Source
  KAKENHI-PROJECT-18H02917
[Presentation] Radiographic joint destruction in the patients with rheumatoid arthritis who have withdrawn, spaced or continued biologics after reaching remission from local biologics registry2019
- Author(s)
  Nagai J, Takakubo Y, Yang S, Suzuki Y, Sasaki A**, Oki H**, Naganuma Y**, Sasaki K**, Takagi M
- Organizer
  The 92nd Annual Meeting of the Japanese Orthopaedic Association
- Data Source
  KAKENHI-PROJECT-18H02917
[Presentation] Distribution of Toll-like receptors expressing immune-cells in rheumatoid synovial tissues of the patients who received CTLA4-Ig agent.2019
- Author(s)
  Takakubo Y, Oki H, Yang S, et al:
- Organizer
  ORS 2019
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K10995
[Presentation] Distrbution of Toll-like receptors expressing immune-cells in rheumatoid synovial tissues of the patients who received CTLA4-Ig agent.2019
- Author(s)
  Takakubo Y, Oki H, Yang S, Sasaki A, Sasaki K, Naganuma Y, KatoY, Takagi M
- Organizer
  ORS 2019 Annual Meeting
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18H02917
[Presentation] Induction of podoplanin in synovial lining cell of lipopolysaccharide-induced rabbit arthritis model.2019
- Author(s)
  Honma R, Maruyama M, Liu X, Oki H, Takakubo Y, Takagi M
- Organizer
  The 2nd International Combined Meeting of Orthopaedic Reserch Societies
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K10995
[Presentation] Anti-tumor necrosis factor agents influence the apoptosis of inflammatory synovial cells in the patients with rheumatoid arthritis.2019
- Author(s)
  Takakubo Y, Suzuki Y, Yang S, Oki H, Takagi M
- Organizer
  The 2nd International Combined Meeting of Orthopaedic Reserch Societies
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18H02917
[Presentation] Radiographic joint destruction in the patients with rheumatoid arthritis who have withdrawn, spaced or continued biologics after reaching remission from local biologics registry.2019
- Author(s)
  Nagai J, Takakubo Y, Yang S, Suzuki Y, Sasaki A, Oki H, Naganuma Y**, Sasaki K**, Takagi M
- Organizer
  The 92nd Annual Meeting of the Japanese Orthopaedic Association
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18H02917
[Presentation] Distribution of immune-suppressive cells and Toll-like receptors in synovial tissues in the patients with rheumatoid arthritis which were treated by anti-TNF agents2019
- Author(s)
  Takakubo Y, Yang S, Suzuki Y, Oki H, Naganuma Y**, Sasaki A**, Sasaki K**, Orui H**, Takagi M
- Organizer
  The 63rd Annual General Assembly and Scientific Meeting of the Japan College of Rheumatology
- Data Source
  KAKENHI-PROJECT-18H02917
[Presentation] Podoplanin is a potential biomarker in lipopolysaccharide-induced inflamed human fibroblast-like synoviocytes.2019
- Author(s)
  Suzuki T, Liu X, Takakubo Y, Oki H**, Honma R, Takagi M
- Organizer
  The 2nd International Combined Meeting of Orthopaedic Reserch Societies
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K10995
[Presentation] Induction of podoplanin in synovial lining cell of lipopolysaccharide-induced rabbit arthritis model.2019
- Author(s)
  Honma R, Maruyama M, Liu X, Oki H, Takakubo Y, Takagi M
- Organizer
  The 2nd International Combined Meeting of Orthopaedic Reserch Societies
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18H02917
[Presentation] Radiographic joint destruction in the patients with rheumatoid arthritis who have withdrawn, spaced or continued biologics after reaching remission from local biologics registry.2019
- Author(s)
  Nagai J, Takakubo Y, Yang S, Suzuki Y, Sasaki A**, Oki H**, Naganuma Y**, Sasaki K**, Takagi M
- Organizer
  The 92nd Annual Meeting of the Japanese Orthopaedic Association
- Data Source
  KAKENHI-PROJECT-17K10995
[Presentation] Utility of alpha-defesin lateral flow device for periprosthetic joint onfection and septic arthritis.2019
- Author(s)
  Narita A, Suzuki A, Nakajima, Takakubo Y, Ito J, Yuki I, Oki H, Naganuma Y, Takagi M
- Organizer
  ORS 2019 Annual Meeting
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18H02917
[Presentation] Podoplanin is a potential biomarker in lipopolysaccharide-induced inflamed human fibroblast-like synoviocytes.2019
- Author(s)
  Suzuki T, Liu X, Takakubo Y, Oki H, Honma R, Takagi M
- Organizer
  The 2nd International Combined Meeting of Orthopaedic Reserch Societies
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18H02917
[Presentation] Foot and ankle surgeries for the patients with rheumatoid arthritis in BIO-era.2018
- Author(s)
  Takakubo Y, Oki H, Sasaki K
- Organizer
  62th Annual Meeting of Japan College of Rheumatology
- Data Source
  KAKENHI-PROJECT-17K10995
[Presentation] The Value of Serum Interleukin-6 Before First Biologis Are Predicted to Clinical Response in The Patients of Rheumatoid Arthritis One Year After The Treatment.2018
- Author(s)
  Takakubo Y, Oki H, Sasaki K, et al:
- Organizer
  ORS 2018
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K10995
[Presentation] The trend of primary total hip arthroplasties for the patients with osteoarthritis in super-aging area in last thirteen years.2018
- Author(s)
  Takakubo Y, Ito J, Oki H, et al
- Organizer
  91th Annual Meeting of JOA
- Data Source
  KAKENHI-PROJECT-17K10995
[Presentation] Toll-like receptors and immune-cells in rheumatoid synovial tissues treated by tocilizumab (TCZ)2018
- Author(s)
  Takakubo Y, Suzuki T, Oki H, et al
- Organizer
  4th Japan Society of Osteoimmunology
- Data Source
  KAKENHI-PROJECT-17K10995
[Presentation] Tumor necrosis factor inhibitors influence the apoptosis of inflammatory cells in rheumatoid synovial tissues.2018
- Author(s)
  Takakubo Y, Oki H, Sasaki K
- Organizer
  62th Annual Meeting of Japan College of Rheumatology
- Data Source
  KAKENHI-PROJECT-17K10995
[Presentation] Infections are increased as the cause of revision total hip arthroplasties in the super-aging area in Northern Japan.2018
- Author(s)
  Takakubo Y, Ito J, Oki H, et al
- Organizer
  EORS
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K10995
[Presentation] Changing of Orthopaedics Surgeries for the Patients with Rheumatoid Arthritis in BIO-era.2018
- Author(s)
  Takakubo Y, Ito J, Oki H, et al
- Organizer
  91th Annual Meeting of JOA
- Data Source
  KAKENHI-PROJECT-17K10995
[Presentation] Expression of inflammatory cytokines from plasmacytoid dendritic cells by stimulation of microparticles2018
- Author(s)
  Takakubo Y, Ainola M, Oki H, et al
- Organizer
  33th Annual Research Meeting of JOA
- Data Source
  KAKENHI-PROJECT-17K10995

1. Takakubo Yuya (80431641)

# of Collaborated Projects: 2 results

# of Collaborated Products: 28 results
2. Takagi Michiaki (40241707)

# of Collaborated Projects: 2 results

# of Collaborated Products: 20 results
3. 佐々木幹 (00444034)

# of Collaborated Projects: 2 results

# of Collaborated Products: 13 results
4. 長沼靖 (10463811)

# of Collaborated Projects: 2 results

# of Collaborated Products: 10 results
5. 伊藤重治 (50764122)

# of Collaborated Projects: 1 results

# of Collaborated Products: 5 results

OKI HIROHARU 大木 弘治

大木 弘治 オオキ ヒロハル

Research Projects

Research Products

Co-Researchers

Innate immune receptor and alternative autophagy in pathogenesis of prosthetic joint infection

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

The role of innate immunology in the patients with early rheumatoid arthritis and resistant-anti rheumatic drugs

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] 生物学的製剤使用関節リウマチ患者における整形外科手術の検討.2019

Author(s)

Journal Title

Data Source

[Journal Article] Disassembly of bilateral bipolar heads within 10 years after hip hemiarthroplasties for avascular necrosis of femoral heads: a case report.2019

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Rapid disappearing of gouty tophi of foot due to reducing urate pool by resection of huge gouty tophi of opposite foot in the patient with hyperuricemia; a case of report.2019

Author(s)

Journal Title

DOI

Data Source

[Presentation] Anti-tumor necrosis factor agents influence the apoptosis of inflammatory synovial cells in the patients with rheumatoid arthritis.2019

Author(s)

Organizer

Data Source

[Presentation] Distrbution of Toll-like receptors expressing immune-cells in rheumatoid synovial tissues of the patients who received CTLA4-Ig agent.2019

Author(s)

Organizer

Data Source

[Presentation] Comparison of clinical features between subtrochanteric and diaphyseal atypical femoral fractures in our super-aging area.2019

Author(s)

Organizer

Data Source

[Presentation] A Novel Monoclonal Antibody SMab-2 Recognizes Endogenous IDH2-R172S of Chondrosarcoma.2019

Author(s)

Organizer

Data Source

[Presentation] Utility of alpha-defesin lateral flow device for periprosthetic joint onfection and septic arthritis.2019

Author(s)

Organizer

Data Source

[Presentation] The trend of revision total hip arthroplasties in super-aging area in last fourteen years.2019

Author(s)

Organizer

Data Source

[Presentation] Radiographic joint destruction in the patients with rheumatoid arthritis who have withdrawn, spaced or continued biologics after reaching remission from local biologics registry2019

Author(s)

Organizer

Data Source

[Presentation] Distribution of Toll-like receptors expressing immune-cells in rheumatoid synovial tissues of the patients who received CTLA4-Ig agent.2019

Author(s)

Organizer

Data Source

[Presentation] Distrbution of Toll-like receptors expressing immune-cells in rheumatoid synovial tissues of the patients who received CTLA4-Ig agent.2019

Author(s)

Organizer

Data Source

[Presentation] Induction of podoplanin in synovial lining cell of lipopolysaccharide-induced rabbit arthritis model.2019

Author(s)

Organizer

Data Source

[Presentation] Anti-tumor necrosis factor agents influence the apoptosis of inflammatory synovial cells in the patients with rheumatoid arthritis.2019

Author(s)

Organizer

Data Source

[Presentation] Radiographic joint destruction in the patients with rheumatoid arthritis who have withdrawn, spaced or continued biologics after reaching remission from local biologics registry.2019

Author(s)

Organizer

Data Source

[Presentation] Distribution of immune-suppressive cells and Toll-like receptors in synovial tissues in the patients with rheumatoid arthritis which were treated by anti-TNF agents2019

OKI HIROHARU 大木弘治

大木弘治オオキヒロハル