Sakimoto Tohru 崎元暢

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SAKIMOTO Tohru 崎元暢

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Researcher Number	20465272
Other IDs
Affiliation (Current)	2025: 日本大学, 医学部, 兼任講師
Affiliation (based on the past Project Information) *help	2020 – 2021: 日本大学, 医学部, 兼任講師 2017 – 2019: 日本大学, 医学部, 准教授 2008 – 2012: Nihon University, 医学部, 助教
Review Section/Research Field	Principal Investigator Ophthalmology / Basic Section 56060:Ophthalmology-related Except Principal Investigator Ophthalmology
Keywords	Principal Investigator 角膜 / 炎症 / 発現制御 / 神経障害性疼痛 / ドライアイ / 角膜知覚 / 培養三叉神経節細胞 / 角膜神経 / 免疫学 / 蛋白質 … More / 生体分子 / 細胞・組織 / 角膜炎症 / インフラマソーム / 抗体点眼 / IL-6レセプター / 上皮実質相互作用 / トランスシグナリング / IL-6R / 抗体 / IL-6 レセプター / IL-6トランスシグナリング / 酵素 / メタロプロテアーゼ / 細胞外ドメインシェディング … More Except Principal Investigator 幹細胞疲弊症眼 / 角膜輪部上皮 / 口腔粘膜上皮 / 家兎 / 眼表面再建 / 口腔粘膜 / 角膜上皮幹細胞疲弊症 Less

角膜神経のドライアイ疼痛症状に関与するメカニズム解明と治療応用Principal Investigator
- Principal Investigator
  
  崎元暢
- Project Period (FY)
  2020 – 2021
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 56060:Ophthalmology-related
- Research Institution
  Nihon University
Role of inflamasome in corneal inflammationPrincipal Investigator
- Principal Investigator
  
  SAKIMOTO Tohru
- Project Period (FY)
  2017 – 2019
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Ophthalmology
- Research Institution
  Nihon University
Simple oral mucosal epithelial transplantation in a rabbit model and clinical application
- Principal Investigator
  
  YAMAGAMI Satoru
- Project Period (FY)
  2017 – 2019
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Ophthalmology
- Research Institution
  Nihon University
The role and pathophysiologic significance of IL-6 trans-signaling in the corneaPrincipal Investigator
- Principal Investigator
  
  SAKIMOTO Tohru
- Project Period (FY)
  2011 – 2012
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Ophthalmology
- Research Institution
  Nihon University
Study of pathophysiologic significance of ectodomain shedding in the corneaPrincipal Investigator
- Principal Investigator
  
  SAKIMOTO Tohru
- Project Period (FY)
  2008 – 2010
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Ophthalmology
- Research Institution
  Nihon University

All 2019 2018 2013 2012 2011 2010 2009 2008 Other

All Journal Article Presentation

[Journal Article] Pro-inflammatory role of NLRP3 inflammasome in experimental sterile corneal inflammation2019
- Author(s)
  Shimizu Hiroaki、Sakimoto Tohru、Yamagami Satoru
- Journal Title
  
  Scientific Reports
  
  Volume: 9 Issue: 1 Pages: 9596-9596
- DOI
  10.1038/s41598-019-46116-9
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K11468
[Journal Article] Implications of Inflammasomes in Human Diseases: NLRP3 Inflammasome and Animal Models2018
- Author(s)
  Tohru Sakimoto
- Journal Title
  
  Cornea
  
  Volume: 37 Issue: 1 Pages: S86-S90
- DOI
  10.1097/ico.0000000000001717
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17K11468
[Journal Article] 涙液検査．1．涙液の生理．2013
- Author(s)
  崎元　暢
- Journal Title
  
  眼科
  
  Volume: 55 Pages: 129-135
- Data Source
  KAKENHI-PROJECT-23792010
[Journal Article] 眼科臨時増刊号眼科薬物療法周辺部角膜潰瘍(Marginal,Moorenulcerなど)2012
- Author(s)
  崎元暢
- Journal Title
  
  眼科
  
  Volume: 54 Pages: 1282-1286
- Data Source
  KAKENHI-PROJECT-23792010
[Journal Article] Anti-inflammatory effect of IL-6 receptor2012
- Author(s)
  Sakimoto T, Sugaya S, Ishimori A, Sawa M
- Journal Title
  
  Experimental Eye Research
  
  Volume: 97 Issue: 1 Pages: 98-104
- DOI
  10.1016/j.exer.2012.02.015
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23792010
[Journal Article] 臨床眼科臨時増刊号オキュラーサーフェイス診療アップデート角膜実質融解におけるMMP.2012
- Author(s)
  崎元暢
- Journal Title
  
  臨床眼科
  
  Volume: 66 Pages: 341-345
- Data Source
  KAKENHI-PROJECT-23792010
[Journal Article] 新しい展望結膜：眼表面におけるムチン研究の動向．2012
- Author(s)
  崎元　暢
- Journal Title
  
  眼科
  
  Volume: 54 Pages: 965-974
- Data Source
  KAKENHI-PROJECT-23792010
[Journal Article] 眼科薬物療法　周辺部角膜潰瘍（Marginal, Mooren ulcerなど）2012
- Author(s)
  崎元　暢
- Journal Title
  
  眼科
  
  Volume: 54 Pages: 1282-1286
- Data Source
  KAKENHI-PROJECT-23792010
[Journal Article] Metalloproteinases in corneal diseases: degradation and processing.2012
- Author(s)
  Sakimoto T
- Journal Title
  
  Cornea
  
  Volume: Suppl 1 Issue: Supplement 1 Pages: S50-S56
- DOI
  10.1097/ico.0b013e318269ccd0
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23792010
[Journal Article] Metalloproteinases in corneal diseases: degradation and processing.2012
- Author(s)
  Sakimoto T, Sawa M
- Journal Title
  
  Cornea
  
  Volume: 31
- Data Source
  KAKENHI-PROJECT-23792010
[Journal Article] 新しい展望結膜:眼表面におけるムチン研究の動向2012
- Author(s)
  崎元暢
- Journal Title
  
  眼科
  
  Volume: 54 Pages: 965-974
- Data Source
  KAKENHI-PROJECT-23792010
[Journal Article] Anti-inflammatory effect of IL-6 receptor blockade in corneal alkali burn.2012
- Author(s)
  Sakimoto T, Sugaya S, Ishimori A, Sawa M
- Journal Title
  
  Exp Eye Res
  
  Volume: 97 Pages: 98-104
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23792010
[Journal Article] オキュラーサーフェイス診療アップデート角膜実質融解におけるMMP.2012
- Author(s)
  崎元　暢
- Journal Title
  
  臨床眼科
  
  Volume: 66 Pages: 341-345
- Data Source
  KAKENHI-PROJECT-23792010
[Journal Article] Regulation of soluble interleukin-6 (IL-6)2011
- Author(s)
  Sugaya S, Sakimoto T, Shoji J, Sawa M
- Journal Title
  
  Japanese Journal of Ophthalmology
  
  Volume: 55 Issue: 3 Pages: 277-282
- DOI
  10.1007/s10384-011-0002-x
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23792010
[Journal Article] Regulation of soluble interleukin-6 (IL-6) receptor release from corneal epithelial cells and its role in the ocular surface.2011
- Author(s)
  Sugaya S, Sakimoto T, Shoji J, Sawa M.
- Journal Title
  
  Jpn J Ophthalmol Epub ahead of print
- NAID
  10029021456
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20791284
[Journal Article] Release of soluble tumor necrosis factor receptor 1 from corneal epithelium by TNF-alpha converting enzyme dependent ectodomain shedding.2009
- Author(s)
  崎元暢
- Journal Title
  
  Investigative Ophthalmology and Visual Science Vol50
  
  Pages: 4618-4621
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20791284
[Journal Article] Release of soluble tumor necrosis factor receptor 1 from corneal epithelium by TNF-alpha converting enzyme dependent ectodomain shedding.2009
- Author(s)
  Sakimoto T, Yamada A, Sawa M
- Journal Title
  
  Invest Ophthalmol Vis Sci 50
  
  Pages: 4618-21
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20791284
[Journal Article] Upregulation of TNF receptor 1 and TNF-alpha converting enzyme during corneal wound healing.2008
- Author(s)
  Sakimoto T, Yamada A, Kanno H, Sawa M
- Journal Title
  
  Jpn J Ophthalmol 52
  
  Pages: 393-398
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20791284
[Journal Article] Upregulation of TNF receptor 1 and TNF-alpha converting enzyme duri na corneal wound healing2008
- Author(s)
  崎元暢
- Journal Title
  
  Japanese Journal of Ophthalmology 52
  
  Pages: 393-398
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20791284
[Journal Article] Regulation of soluble interleukin-6(IL-6)receptor release from corneal epithelial cell and its role in ocular surface.
- Author(s)
  崎元暢
- Journal Title
  
  Japanese Journal of Ophthalmology
  
  Volume: (印刷中)
- NAID
  10029021456
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20791284
[Presentation] 前眼部炎症とTh17細胞系蛋白2013
- Author(s)
  山田愛、崎元暢、石森秋子、大西貴子、菅谷哲史、澤充
- Organizer
  第37回日本角膜学会総会・第29回日本角膜移植学会.
- Place of Presentation
  和歌山
- Year and Date
  2013-02-15
- Data Source
  KAKENHI-PROJECT-23792010
[Presentation] The effects of IL-6 receptor blockade on gene expressions in experimental corneal alkali burn2013
- Author(s)
  Sugaya , Sakimoto T, Yamada A, Ohnishi T, Ishimori A, Sawa M
- Organizer
  ARVO
- Place of Presentation
  Seattle, WA
- Year and Date
  2013-05-07
- Data Source
  KAKENHI-PROJECT-23792010
[Presentation] 角膜アルカリ外傷における抗Interleukin-6受容体抗体点眼後の遺伝子発現の変化2013
- Author(s)
  菅谷哲史、崎元暢、山田愛、大西貴子、石森秋子、澤充
- Organizer
  第37回日本角膜学会総会・第29回日本角膜移植学会.
- Place of Presentation
  和歌山
- Year and Date
  2013-02-14
- Data Source
  KAKENHI-PROJECT-23792010
[Presentation] 細胞外ドメインシェディング亢進によるtumor necrosis factor-alphaの角膜上皮細胞内シグナル阻害効果の検討2013
- Author(s)
  崎元暢、石森秋子、澤充
- Organizer
  第117回日本眼科学会総会.
- Place of Presentation
  東京
- Year and Date
  2013-04-05
- Data Source
  KAKENHI-PROJECT-23792010
[Presentation] Effect of Interleukin-17(IL-17) and IL-17 receptor on ocular surface inflammation2013
- Author(s)
  Yamada A, Sakimoto T, Ishimori A, Ohnishi T, Sugaya S, Sawa M
- Organizer
  ARVO
- Place of Presentation
  Seattle, WA
- Year and Date
  2013-05-06
- Data Source
  KAKENHI-PROJECT-23792010
[Presentation] Anti-inflammatory effect of IL-6 receptor blockade on corneal alkali burn2012
- Author(s)
  Sakimoto T, Sugaya S, Ishimori A, Sawa M
- Organizer
  ARVO
- Place of Presentation
  Fort Lauderdale, FL, USA
- Year and Date
  2012-05-09
- Data Source
  KAKENHI-PROJECT-23792010
[Presentation] Metalloproteinase and corneal diseases ?degradation and processing-2012
- Author(s)
  Sakimoto T
- Organizer
  17th annual meeting of the Kyoto Corneal Club.
- Place of Presentation
  京都
- Year and Date
  2012-12-02
- Data Source
  KAKENHI-PROJECT-23792010
[Presentation] 角膜上皮におけるP2Y受容体を介した細胞外ドメインシェディングの検討2012
- Author(s)
  崎元暢、澤充
- Organizer
  第36回日本角膜学会総会.
- Place of Presentation
  東京
- Year and Date
  2012-02-24
- Data Source
  KAKENHI-PROJECT-23792010
[Presentation] アルカリ外傷角膜実質中の炎症関連分子発現に対するIL-6受容体阻害効果2012
- Author(s)
  崎元暢、菅谷哲史、石森秋子、澤充
- Organizer
  第116回日本眼科学会総会
- Place of Presentation
  東京
- Year and Date
  2012-04-05
- Data Source
  KAKENHI-PROJECT-23792010
[Presentation] 角膜内皮障害の診断と手術適応2011
- Author(s)
  崎元暢
- Organizer
  第34回日本眼科手術学会総会
- Place of Presentation
  京都国際会館(京都府)(シンポジウム)
- Year and Date
  2011-01-29
- Data Source
  KAKENHI-PROJECT-20791284
[Presentation] Metalloproteinase and corneal diseases2011
- Author(s)
  Sakimoto T
- Organizer
  17th annual meeting of the Kyoto Corneal Club.
- Place of Presentation
  都ホテル京都（京都）
- Data Source
  KAKENHI-PROJECT-23792010
[Presentation] 角膜内皮障害の診断と手術適応2011
- Author(s)
  崎元暢
- Organizer
  第34回日本眼科手術学会総会シンポジウム角膜内皮疾患に対する外科的アプローチ
- Place of Presentation
  京都
- Year and Date
  2011-01-29
- Data Source
  KAKENHI-PROJECT-20791284
[Presentation] Regulation of soluble IL-6 receptor release from corneal epithelial cell by ectodo main shedding and mRNA splicing.2010
- Author(s)
  崎元暢
- Organizer
  2nd Asia Cornea Society Biennial Scientific Meeting.
- Place of Presentation
  都ホテル京都(京都府)
- Year and Date
  2010-12-02
- Data Source
  KAKENHI-PROJECT-20791284
[Presentation] 角膜上皮細胞と涙液における可溶性IL-6R発現の検討2010
- Author(s)
  菅谷哲史、崎元暢、庄司純、澤充
- Organizer
  第114回日本眼科学会総会
- Place of Presentation
  名古屋
- Data Source
  KAKENHI-PROJECT-20791284
[Presentation] 角膜上皮-実質相互作用におけるIL-6トランスシグナリングの役割2010
- Author(s)
  崎元暢
- Organizer
  第15回眼創傷治癒研究会
- Place of Presentation
  和歌山マリーナシティロイヤルパインホテル(和歌山県)
- Year and Date
  2010-08-21
- Data Source
  KAKENHI-PROJECT-20791284
[Presentation] 角膜上皮-実質相互作用におけるIL-6トランスシグナリングの役割2010
- Author(s)
  崎元暢、澤充
- Organizer
  第15回眼創傷治癒研究会
- Place of Presentation
  和歌山
- Year and Date
  2010-08-21
- Data Source
  KAKENHI-PROJECT-20791284
[Presentation] Regulation of soluble IL-6 receptor release from corneal epithelial cell by ectodomain shedding and mRNA splicing.2010
- Author(s)
  Sakimoto T, Sugaya S, Ohnishi T, Shoji J, Sawa M
- Organizer
  2nd Asia Cornea Society Biennial Scientific Meeting
- Place of Presentation
  Kyoto
- Year and Date
  2010-12-02
- Data Source
  KAKENHI-PROJECT-20791284
[Presentation] シェーグレン症候群症例における涙液中の可溶性TNFレセプター1発現の検討2009
- Author(s)
  崎元暢
- Organizer
  第33回角膜カンファランス
- Place of Presentation
  大阪・リッツカールトン大阪
- Year and Date
  2009-02-20
- Data Source
  KAKENHI-PROJECT-20791284
[Presentation] 蛍光マイクロビーズアレイシステムを用いた涙液中サイトカイン受容体の発現解析2009
- Author(s)
  菅谷哲史、大西貴子、崎元暢、澤充
- Organizer
  第63回日本臨床眼科学会
- Place of Presentation
  福岡
- Year and Date
  2009-10-11
- Data Source
  KAKENHI-PROJECT-20791284
[Presentation] シェーグレン症候群症例における涙液中の可溶性TNFレセプター1発現の検討2009
- Author(s)
  崎元暢、佐々木淳、加島陽二、澤充
- Organizer
  第33回角膜カンファランス・第25回日本角膜移植学会
- Place of Presentation
  大阪
- Year and Date
  2009-02-20
- Data Source
  KAKENHI-PROJECT-20791284
[Presentation] 円錐角膜におけるADAMファミリーを介する蛋白発現の検討2009
- Author(s)
  菅谷哲史、崎元暢、澤充
- Organizer
  第33回角膜カンファランス・第25回日本角膜移植学会
- Place of Presentation
  大阪
- Year and Date
  2009-02-19
- Data Source
  KAKENHI-PROJECT-20791284
[Presentation] 結膜上皮における細胞外ドメインシェディングを介した可溶性TNFレセプター産生2008
- Author(s)
  崎元暢
- Organizer
  第112回日本眼科学会総会
- Place of Presentation
  横浜・パシフィコ横浜
- Year and Date
  2008-04-28
- Data Source
  KAKENHI-PROJECT-20791284
[Presentation] TACE(ADAM17) dependent shedding of soluble TNF receptor in conjunc tival enithelium2008
- Author(s)
  崎元暢
- Organizer
  The annual meeting of Association for Research i n Vision and Ophthalmology 2008
- Place of Presentation
  Fort Lauderdale, FL, USA
- Year and Date
  2008-04-28
- Data Source
  KAKENHI-PROJECT-20791284
[Presentation] 結膜上皮における細胞外ドメインシェディングを介した可溶性TNFレセプター産生2008
- Author(s)
  崎元暢、山田愛、庄司純、澤充
- Organizer
  第112回日本眼科学会総会
- Place of Presentation
  横浜
- Year and Date
  2008-04-18
- Data Source
  KAKENHI-PROJECT-20791284
[Presentation] TACE(ADAM17) dependent shedding of soluble TNF receptor in conjunctival epithelium.2008
- Author(s)
  Sakimoto T, Yamada A, Shoji J, Sawa M
- Organizer
  ARVO
- Place of Presentation
  Fort Lauderdale, FL
- Year and Date
  2008-04-28
- Data Source
  KAKENHI-PROJECT-20791284
[Presentation] アルカリ外傷角膜実質中の炎症関連分子発現に対するIL-6受容体阻害効果．
- Author(s)
  崎元　暢
- Organizer
  第116回日本眼科学会総会
- Place of Presentation
  東京
- Data Source
  KAKENHI-PROJECT-23792010
[Presentation] Anti-inflammatory effect of IL-6 receptor blockade on corneal alkali burn.
- Author(s)
  Sakimoto T
- Organizer
  ARVO2012
- Place of Presentation
  Fort Lauderdale, FL, USA
- Data Source
  KAKENHI-PROJECT-23792010

1. YAMAGAMI Satoru (10220245)

# of Collaborated Projects: 2 results

# of Collaborated Products: 1 results
2. 中靜裕之 (10372997)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results

Sakimoto Tohru 崎元 暢

SAKIMOTO Tohru 崎元 暢

Research Projects

Research Products

Co-Researchers

角膜神経のドライアイ疼痛症状に関与するメカニズム解明と治療応用Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Role of inflamasome in corneal inflammationPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Simple oral mucosal epithelial transplantation in a rabbit model and clinical application

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

The role and pathophysiologic significance of IL-6 trans-signaling in the corneaPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Study of pathophysiologic significance of ectodomain shedding in the corneaPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] Pro-inflammatory role of NLRP3 inflammasome in experimental sterile corneal inflammation2019

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Implications of Inflammasomes in Human Diseases: NLRP3 Inflammasome and Animal Models2018

Author(s)

Journal Title

DOI

Data Source

[Journal Article] 涙液検査．1．涙液の生理．2013

Author(s)

Journal Title

Data Source

[Journal Article] 眼科臨時増刊号眼科薬物療法周辺部角膜潰瘍(Marginal,Moorenulcerなど)2012

Author(s)

Journal Title

Data Source

[Journal Article] Anti-inflammatory effect of IL-6 receptor2012

Author(s)

Journal Title

DOI

Data Source

[Journal Article] 臨床眼科臨時増刊号オキュラーサーフェイス診療アップデート角膜実質融解におけるMMP.2012

Author(s)

Journal Title

Data Source

[Journal Article] 新しい展望 結膜：眼表面におけるムチン研究の動向．2012

Author(s)

Journal Title

Data Source

[Journal Article] 眼科薬物療法 周辺部角膜潰瘍（Marginal, Mooren ulcerなど）2012

Author(s)

Journal Title

Data Source

[Journal Article] Metalloproteinases in corneal diseases: degradation and processing.2012

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Metalloproteinases in corneal diseases: degradation and processing.2012

Author(s)

Journal Title

Data Source

[Journal Article] 新しい展望結膜:眼表面におけるムチン研究の動向2012

Sakimoto Tohru 崎元暢

SAKIMOTO Tohru 崎元暢

[Journal Article] 新しい展望結膜：眼表面におけるムチン研究の動向．2012

[Journal Article] 眼科薬物療法　周辺部角膜潰瘍（Marginal, Mooren ulcerなど）2012

[Journal Article] オキュラーサーフェイス診療アップデート角膜実質融解におけるMMP.2012

[Presentation] 細胞外ドメインシェディング亢進によるtumor necrosis factor-alphaの角膜上皮細胞内シグナル阻害効果の検討2013