Karube Kennosuke 加留部謙之輔

… Alternative Names

KARUBE Kennosuke 加留部謙之輔

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Researcher Number	20508577
Other IDs	https://orcid.org/0000-0002-1205-858X
Affiliation (Current)	2025: 名古屋大学, 医学系研究科, 教授
Affiliation (based on the past Project Information) *help	2023 – 2024: 名古屋大学, 医学系研究科, 教授 2021: 名古屋大学, 医学系研究科, 教授 2019 – 2021: 琉球大学, 医学(系)研究科(研究院), 教授 2017: 琉球大学, 大学院医学研究科, 教授 2015 – 2017: 琉球大学, 医学(系)研究科(研究院), 教授 2008 – 2012: Aichi Cancer Center Research Institute, 遺伝子医療研究部, 主任研究員
Review Section/Research Field	Principal Investigator Human pathology / Basic Section 49020:Human pathology-related / Hematology Except Principal Investigator Basic Section 52040:Radiological sciences-related
Keywords	Principal Investigator 悪性リンパ腫 / ゲノム解析 / 発現解析 / NK細胞リンパ腫 / in situ hybridization / HTLV-1 / PRDM1 / アレイCGH / ATLL / T細胞 … More / ホジキンリンパ腫 / tax / FFPE標本 / RNAscope / HBZ / 成人T細胞白血病/リンパ腫 / JAK-STAT経路 / 予後 / リンパ腫 / びまん性大細胞型B細胞リンパ腫 / STAT3 / 次世代シークエンス / JAK-STAT / 遺伝子変異 / FOX03 / FOXO3 / NK細胞 / 疾患分類 / 発がん / マイクロアレイ / RT-PCR / T細胞リンパ腫 / NK … More Except Principal Investigator 慢性腎臓病 / 腎線維化 / T1ρ値計測 / 層別化 / 前立腺癌 / 予後解析 / 画像診断 / 腎 / Radiomics / テクスチャー解析 / MRI / FDG-PET/CT / 前立腺腫瘍 / 悪性度評価 / 腎腫瘍 Less

新規病態：HTLV-1陽性HRS細胞を伴う成人T細胞白血病/リンパ腫の統合的解析Principal Investigator
- Principal Investigator
  
  加留部謙之輔
- Project Period (FY)
  2023 – 2026
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 49020:Human pathology-related
- Research Institution
  Nagoya University
A new diagnostic algorithm using biopsy specimens in adult T-cell leukemia/lymphoma: combination of RNA in situ hybridization and quantitative PCR for HTLV-1Principal Investigator
- Principal Investigator
  
  Karube Kennosuke
- Project Period (FY)
  2019 – 2021
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 49020:Human pathology-related
- Research Institution
  Nagoya University
  University of the Ryukyus
Non invasive estimation of renal fibrosis using MRI and texture analysis
- Principal Investigator
  
  Ishigami Kousei
- Project Period (FY)
  2019 – 2021
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 52040:Radiological sciences-related
- Research Institution
  Kyushu University
  University of the Ryukyus
Analysis of JAK-STAT pathway in diffuse large B-cell lymphomaPrincipal Investigator
- Principal Investigator
  
  Karube Kennosuke
- Project Period (FY)
  2015 – 2017
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Human pathology
- Research Institution
  University of the Ryukyus
NK細胞性リンパ腫の分子病態の解明および新規薬剤の探索Principal Investigator
- Principal Investigator
  
  加留部謙之輔
- Project Period (FY)
  2012
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Hematology
- Research Institution
  Aichi Cancer Center Research Institute
The molecular analyses of extranodal NK/T cell lymphoma, nasal typePrincipal Investigator
- Principal Investigator
  
  KARUBE Kennosuke
- Project Period (FY)
  2010 – 2011
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Human pathology
- Research Institution
  Aichi Cancer Center Research Institute
The gene expression profile of extranodal NK/T cell lymphoma, nasal typePrincipal Investigator
- Principal Investigator
  
  KARUBE Kennosuke
- Project Period (FY)
  2008 – 2009
- Research Category
  
  Grant-in-Aid for Young Scientists (Start-up)
- Research Field
  
  Human pathology
- Research Institution
  Aichi Cancer Center Research Institute

All 2021 2018 2017 2013 2012 2011 2010 2009 2008

All Journal Article Presentation Book

[Book] 若手医師のためのリンパ腫セミナー-エキスパートによる講義録2012
- Author(s)
  加留部謙之輔
- Publisher
  日本リンパ網内系学会
- Data Source
  KAKENHI-PROJECT-22790368
[Book] 血液診療エキスパート悪性リンパ腫2010
- Author(s)
  加留部謙之輔、瀬戸加大
- Publisher
  中外医学社
- Data Source
  KAKENHI-PROJECT-22790368
[Journal Article] A new diagnostic algorithm using biopsy specimens in adult T-cell leukemia/lymphoma: combination of RNA in situ hybridization and quantitative PCR for HTLV-1.2021
- Author(s)
  Takatori M, Sakihama S, Miyara M, Imaizumi N, Miyagi T, Ohshiro K, Nakazato I, Hayashi M, Todoroki J, Morishima S, Masuzaki H, Fukushima T, Karube K.
- Journal Title
  
  Modern Pathology
  
  Volume: 34 Issue: 1 Pages: 51-58
- DOI
  10.1038/s41379-020-0635-8
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K07438, KAKENHI-PROJECT-20K08912
[Journal Article] Integrating genomic alterations in diffuse large B-cell lymphoma identifies new relevant pathways and potential therapeutic targets.2018
- Author(s)
  Karube K, Miyawaki K, Kato K, Akashi K, , Campo E et al.
- Journal Title
  
  Leukemia
  
  Volume: 32 Issue: 3 Pages: 675-684
- DOI
  10.1038/leu.2017.251
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K09875, KAKENHI-PROJECT-16H06391, KAKENHI-PROJECT-15K08371
[Journal Article] Peripheral T-cell lymphoma with EBV-infected "anaplastic" B cell proliferation confined to sinuses.2017
- Author(s)
  Keisuke Kawasaki, Kennosuke Karube.
- Journal Title
  
  Blood
  
  Volume: 129 Issue: 13 Pages: 1885-1885
- DOI
  10.1182/blood-2016-11-751974
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-15K08371
[Journal Article] Clinicobiological features and prognostic impact of diffuse large B-cell lymphoma component in the outcome of patients with previously untreated follicular lymphoma.2017
- Author(s)
  Magnano L, Balague O, Dlouhy I, Rovira J, Karube K, Pinyol M, Rivas-Delgado A, Costa D, Martinez-Trillos A, Gonzalez-Farre B, Martinez-Pozo A, Gine; E, Colomer D, Delgado J, Villamor N, Campo E, Lopez-Guillermo A.
- Journal Title
  
  Annals Oncology
  
  Volume: 28 Issue: 11 Pages: 2799-2805
- DOI
  10.1093/annonc/mdx407
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K08371
[Journal Article] Human T-cell leukemia virus type I Tax genotype analysis in Okinawa, the southernmost and remotest islands of Japan: Different distributions compared with mainland Japan and the potential value for the prognosis of aggressive adult T-cell leukemia/lymphoma2017
- Author(s)
  Sakihama Shugo、Saito Mineki、Kuba-Miyara Megumi、Tomoyose Takeaki、Taira Naoya、Miyagi Takashi、Hayashi Masaki、Kinjo Shigeko、Nakachi Sawako、Tedokon Iori、Nishi Yukiko、Tamaki Keita、Morichika Kazuho、Uchihara Jun-nosuke、Morishima Satoko、Karube Ken-nosuke、Tanaka Yuetsu、Masuzaki Hiroaki、Fukushima Takuya
- Journal Title
  
  Leuk Res
  
  Volume: 61 Pages: 18-24
- DOI
  10.1016/j.leukres.2017.08.006
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K09839, KAKENHI-PROJECT-15K08371, KAKENHI-PROJECT-15K09345
[Journal Article] Comprehensive gene expression profiles of NK cell neoplasms identify vorinostat as an effective drug candidate.2013
- Author(s)
  Karube K
- Journal Title
  
  Cancer Letter
  
  Volume: (in press)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24790987
[Journal Article] Lineage-specific growth inhibition of NK cell lines by FOXO3 in association with Akt activation status.2012
- Author(s)
  Karube K
- Journal Title
  
  Experimental Hematology
  
  Volume: 40
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24790987
[Journal Article] Identification of FOXO3 and PRDM1 as tumor suppressor gene candidates in NK cell neoplasms by genomic and functional analyses2011
- Author(s)
  Karube K, et al
- Journal Title
  
  Blood
  
  Volume: 118 Issue: 12 Pages: 3195-3204
- DOI
  10.1182/blood-2011-04-346890
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22790368
[Journal Article] Pathological and immunohistological findings and genetic aberrations of intestinal enteropathy-associated T cell lymphoma in Japan2011
- Author(s)
  Takeshita M, Nakamura S, Karube K
- Journal Title
  
  Histopathology
  
  Volume: 58(3) Pages: 395-407
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22790368
[Journal Article] Identification of FOXO3 and PRDM1 as tumor suppressor gene candidates in NK cell neoplasms by genomic and functional analyses2011
- Author(s)
  Karube K, Nakagawa M
- Journal Title
  
  Blood
  
  Volume: 118(12) Pages: 3195-204
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22790368
[Journal Article] Genomic profiling combined with gene expression profiling in primary central nervous system lymphoma2010
- Author(s)
  Sung CO, Kim SC, Karnan S, Karube K
- Journal Title
  
  Blood
  
  Volume: 117(4) Pages: 1290-300
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22790368
[Journal Article] The International Prognostic Index predicts outcome in aggressive adult T-cell leukemia/lymphoma : analysis of 126 patients from the International Peripheral T-Cell Lymphoma Project2009
- Author(s)
  Suzumiya J, Ohshima K, Tamura K, Karube K, 他6名
- Journal Title
  
  Annals of Oncology 20
  
  Pages: 715-721
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20890298
[Journal Article] Plasmacytoid dendritic cells prime alloreactive T cells to mediate graft-versus-host disease as antigen-presenting cells2009
- Author(s)
  Koyama M, Hashimoto D, Aoyama K, Matsuoka K, Karube K, 他5名
- Journal Title
  
  Blood 113
  
  Pages: 2088-2095
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20890298
[Journal Article] Plasmacytoid dendritic cells prime alloreactive T cells to mediate graft-versus-host disease as antigen presenting cells.2009
- Author(s)
  Koyama M, Hashimoto D, Aoyama K, Matsuoka K, Karube K (他5名, 5番目)
- Journal Title
  
  Blood 113
  
  Pages: 2088-95
- Data Source
  KAKENHI-PROJECT-20890298
[Journal Article] Hepatocellular apoptosis associated with cytotoxic/natural killer-cell infiltration in chronic active EBV infection.2009
- Author(s)
  Nomura Y, Kimura H, Karube K, (他11名, 3番目)
- Journal Title
  
  Pathol Int. 59
  
  Pages: 438-42
- Data Source
  KAKENHI-PROJECT-20890298
[Journal Article] The International Prognostic Index predicts outcome in aggressive adult T cell leukemia/lymphoma: analysis of 126 patients from the International peripheral T-cell lymphoma project2009
- Author(s)
  Suzumiya J, Ohshima K, Tamura K, Karube K, (他6名, 4番目)
- Journal Title
  
  Annal Oncol. 20
  
  Pages: 715-21
- Data Source
  KAKENHI-PROJECT-20890298
[Journal Article] BCL6 gene amplification/3q27 gain is associated with unique clinicopathological characteristics among follicular lymphoma without BCL2 gene translocation2008
- Author(s)
  Karube K, 他13名
- Journal Title
  
  Modern Pathology 21
  
  Pages: 973-978
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20890298
[Presentation] NK細胞性腫瘍に特異的ながん抑制遺伝子であるFOXO3.2012
- Author(s)
  加留部謙之輔
- Organizer
  第71回日本癌学会学術総会
- Place of Presentation
  ロイトン札幌(札幌)
- Year and Date
  2012-09-19
- Data Source
  KAKENHI-PROJECT-24790987
[Presentation] Genomic and functional analyses of NK-cell neoplasms2012
- Author(s)
  加留部謙之輔
- Organizer
  4th T cell lymphoma forum
- Place of Presentation
  ホテル日航サンフランシスコ(サンフランシスコ)
- Year and Date
  2012-01-26
- Data Source
  KAKENHI-PROJECT-22790368
[Presentation] 悪生リンパ腫の臨床病理および分子病態の解析.2012
- Author(s)
  加留部謙之輔
- Organizer
  第71回日本癌学会学術総会
- Place of Presentation
  ロイトン札幌(札幌)
- Year and Date
  2012-09-21
- Data Source
  KAKENHI-PROJECT-24790987
[Presentation] Identification of FOXO3 and PRDM1 as tumor suppressor gene candidates in NK cell neoplasms by the combination of genomic and functional analyses2011
- Author(s)
  Kennosuke Karube, Masao Nakagawa, Shinobu Tsuzuki, Young-Hyeh Ko, Shigeo Nakamura, Masao Seto
- Organizer
  第11回国際リンパ腫会議
- Place of Presentation
  ルルガノ(スイス)
- Year and Date
  2011-06-16
- Data Source
  KAKENHI-PROJECT-22790368
[Presentation] NK細胞性腫瘍におけるFOXO3およびPRDM1のがん抑制遺伝子としての意義2011
- Author(s)
  加留部謙之輔,中川雅夫,都築忍,清水則夫,中村栄男,高田尚良,瀬戸加大
- Organizer
  第70回日本癌学会学術総会ポスター
- Place of Presentation
  名古屋国際会議場
- Year and Date
  2011-10-05
- Data Source
  KAKENHI-PROJECT-22790368
[Presentation] The genomic analysis of NK/T cell neoplasms2010
- Author(s)
  加留部謙之輔
- Organizer
  第69回日本癌学会学術総会
- Place of Presentation
  大阪国際会議場(大阪市)
- Year and Date
  2010-09-22
- Data Source
  KAKENHI-PROJECT-22790368
[Presentation] The gene expression profile of NK/T cell neoplasm(ポスター)2009
- Author(s)
  Karube K, et al
- Organizer
  第68回日本癌学会学術総会
- Place of Presentation
  横浜)
- Year and Date
  2009-10-02
- Data Source
  KAKENHI-PROJECT-20890298
[Presentation] The gene expression profile of NK/T cell neoplasm2009
- Author(s)
  加留部, 謙之輔
- Organizer
  第68回日本癌学会学術総会
- Place of Presentation
  パシフィコ横浜(横浜市)
- Year and Date
  2009-10-02
- Data Source
  KAKENHI-PROJECT-20890298
[Presentation] 謙之輔NK/T細胞性腫瘍の遺伝子発現プロファイル(ポスター)2008
- Author(s)
  加留部
- Organizer
  第67回日本癌学会学術総会
- Place of Presentation
  名古屋
- Year and Date
  2008-10-28
- Data Source
  KAKENHI-PROJECT-20890298
[Presentation] NK/T細胞性腫瘍の遺伝子発現プロファイル2008
- Author(s)
  加留部, 謙之輔, 他4名
- Organizer
  第67回日本癌学会学術総会
- Place of Presentation
  名古屋国際会議場
- Year and Date
  2008-10-28
- Data Source
  KAKENHI-PROJECT-20890298

1. Ishigami Kousei (10403916)

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2. 大島孝一 (50203766)

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3. 村山貞之 (60239548)

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4. 伊良波裕子 (50305207)

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5. 與儀彰 (80510718)

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6. 齋藤誠一 (80235043)

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7. 石塚賢治 (10441742)

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8. 加藤光次 (20571764)

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9. 福島卓也 (40336160)

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10. 佐藤賢文 (70402807)

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11. 下田和哉 (90311844)

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12. Miyawaki Kohta

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13. Akashi Koichi

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14. 益崎裕章

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Karube Kennosuke 加留部 謙之輔

KARUBE Kennosuke 加留部 謙之輔

Research Projects

Research Products

Co-Researchers

新規病態：HTLV-1陽性HRS細胞を伴う成人T細胞白血病/リンパ腫の統合的解析Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

A new diagnostic algorithm using biopsy specimens in adult T-cell leukemia/lymphoma: combination of RNA in situ hybridization and quantitative PCR for HTLV-1Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Non invasive estimation of renal fibrosis using MRI and texture analysis

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Analysis of JAK-STAT pathway in diffuse large B-cell lymphomaPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

NK細胞性リンパ腫の分子病態の解明および新規薬剤の探索Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

The molecular analyses of extranodal NK/T cell lymphoma, nasal typePrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

The gene expression profile of extranodal NK/T cell lymphoma, nasal typePrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Book] 若手医師のためのリンパ腫セミナー-エキスパートによる講義録2012

Author(s)

Publisher

Data Source

[Book] 血液診療エキスパート悪性リンパ腫2010

Author(s)

Publisher

Data Source

[Journal Article] A new diagnostic algorithm using biopsy specimens in adult T-cell leukemia/lymphoma: combination of RNA in situ hybridization and quantitative PCR for HTLV-1.2021

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Integrating genomic alterations in diffuse large B-cell lymphoma identifies new relevant pathways and potential therapeutic targets.2018

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Peripheral T-cell lymphoma with EBV-infected "anaplastic" B cell proliferation confined to sinuses.2017

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Clinicobiological features and prognostic impact of diffuse large B-cell lymphoma component in the outcome of patients with previously untreated follicular lymphoma.2017

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Human T-cell leukemia virus type I Tax genotype analysis in Okinawa, the southernmost and remotest islands of Japan: Different distributions compared with mainland Japan and the potential value for the prognosis of aggressive adult T-cell leukemia/lymphoma2017

Author(s)

Journal Title

DOI

Data Source

Karube Kennosuke 加留部謙之輔

KARUBE Kennosuke 加留部謙之輔