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Karube Kennosuke  加留部 謙之輔

… Alternative Names

KARUBE Kennosuke  加留部 謙之輔

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Researcher Number 20508577
Other IDs
  • ORCIDhttps://orcid.org/0000-0002-1205-858X
Affiliation (Current) 2025: 名古屋大学, 医学系研究科, 教授
Affiliation (based on the past Project Information) *help 2023 – 2024: 名古屋大学, 医学系研究科, 教授
2021: 名古屋大学, 医学系研究科, 教授
2019 – 2021: 琉球大学, 医学(系)研究科(研究院), 教授
2017: 琉球大学, 大学院医学研究科, 教授
2015 – 2017: 琉球大学, 医学(系)研究科(研究院), 教授
2008 – 2012: Aichi Cancer Center Research Institute, 遺伝子医療研究部, 主任研究員
Review Section/Research Field
Principal Investigator
Human pathology / Basic Section 49020:Human pathology-related / Hematology
Except Principal Investigator
Basic Section 52040:Radiological sciences-related
Keywords
Principal Investigator
悪性リンパ腫 / ゲノム解析 / 発現解析 / NK細胞リンパ腫 / in situ hybridization / HTLV-1 / PRDM1 / アレイCGH / ATLL / T細胞 … More / ホジキンリンパ腫 / tax / FFPE標本 / RNAscope / HBZ / 成人T細胞白血病/リンパ腫 / JAK-STAT経路 / 予後 / リンパ腫 / びまん性大細胞型B細胞リンパ腫 / STAT3 / 次世代シークエンス / JAK-STAT / 遺伝子変異 / FOX03 / FOXO3 / NK細胞 / 疾患分類 / 発がん / マイクロアレイ / RT-PCR / T細胞リンパ腫 / NK … More
Except Principal Investigator
慢性腎臓病 / 腎線維化 / T1ρ値計測 / 層別化 / 前立腺癌 / 予後解析 / 画像診断 / 腎 / Radiomics / テクスチャー解析 / MRI / FDG-PET/CT / 前立腺腫瘍 / 悪性度評価 / 腎腫瘍 Less
  • Research Projects

    (7 results)
  • Research Products

    (29 results)
  • Co-Researchers

    (14 People)
  •  新規病態:HTLV-1陽性HRS細胞を伴う成人T細胞白血病/リンパ腫の統合的解析Principal Investigator

    • Principal Investigator
      加留部 謙之輔
    • Project Period (FY)
      2023 – 2026
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Review Section
      Basic Section 49020:Human pathology-related
    • Research Institution
      Nagoya University
  •  A new diagnostic algorithm using biopsy specimens in adult T-cell leukemia/lymphoma: combination of RNA in situ hybridization and quantitative PCR for HTLV-1Principal Investigator

    • Principal Investigator
      Karube Kennosuke
    • Project Period (FY)
      2019 – 2021
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 49020:Human pathology-related
    • Research Institution
      Nagoya University
      University of the Ryukyus
  •  Non invasive estimation of renal fibrosis using MRI and texture analysis

    • Principal Investigator
      Ishigami Kousei
    • Project Period (FY)
      2019 – 2021
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 52040:Radiological sciences-related
    • Research Institution
      Kyushu University
      University of the Ryukyus
  •  Analysis of JAK-STAT pathway in diffuse large B-cell lymphomaPrincipal Investigator

    • Principal Investigator
      Karube Kennosuke
    • Project Period (FY)
      2015 – 2017
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Human pathology
    • Research Institution
      University of the Ryukyus
  •  NK細胞性リンパ腫の分子病態の解明および新規薬剤の探索Principal Investigator

    • Principal Investigator
      加留部 謙之輔
    • Project Period (FY)
      2012
    • Research Category
      Grant-in-Aid for Young Scientists (B)
    • Research Field
      Hematology
    • Research Institution
      Aichi Cancer Center Research Institute
  •  The molecular analyses of extranodal NK/T cell lymphoma, nasal typePrincipal Investigator

    • Principal Investigator
      KARUBE Kennosuke
    • Project Period (FY)
      2010 – 2011
    • Research Category
      Grant-in-Aid for Young Scientists (B)
    • Research Field
      Human pathology
    • Research Institution
      Aichi Cancer Center Research Institute
  •  The gene expression profile of extranodal NK/T cell lymphoma, nasal typePrincipal Investigator

    • Principal Investigator
      KARUBE Kennosuke
    • Project Period (FY)
      2008 – 2009
    • Research Category
      Grant-in-Aid for Young Scientists (Start-up)
    • Research Field
      Human pathology
    • Research Institution
      Aichi Cancer Center Research Institute

All 2021 2018 2017 2013 2012 2011 2010 2009 2008

All Journal Article Presentation Book

  • [Book] 若手医師のためのリンパ腫セミナー-エキスパートによる講義録2012

    • Author(s)
      加留部謙之輔
    • Publisher
      日本リンパ網内系学会
    • Data Source
      KAKENHI-PROJECT-22790368
  • [Book] 血液診療エキスパート悪性リンパ腫2010

    • Author(s)
      加留部謙之輔、瀬戸加大
    • Publisher
      中外医学社
    • Data Source
      KAKENHI-PROJECT-22790368
  • [Journal Article] A new diagnostic algorithm using biopsy specimens in adult T-cell leukemia/lymphoma: combination of RNA in situ hybridization and quantitative PCR for HTLV-1.2021

    • Author(s)
      Takatori M, Sakihama S, Miyara M, Imaizumi N, Miyagi T, Ohshiro K, Nakazato I, Hayashi M, Todoroki J, Morishima S, Masuzaki H, Fukushima T, Karube K.
    • Journal Title

      Modern Pathology

      Volume: 34 Issue: 1 Pages: 51-58

    • DOI

      10.1038/s41379-020-0635-8

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-19K07438, KAKENHI-PROJECT-20K08912
  • [Journal Article] Integrating genomic alterations in diffuse large B-cell lymphoma identifies new relevant pathways and potential therapeutic targets.2018

    • Author(s)
      Karube K, Miyawaki K, Kato K, Akashi K, , Campo E et al.
    • Journal Title

      Leukemia

      Volume: 32 Issue: 3 Pages: 675-684

    • DOI

      10.1038/leu.2017.251

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-16K09875, KAKENHI-PROJECT-16H06391, KAKENHI-PROJECT-15K08371
  • [Journal Article] Peripheral T-cell lymphoma with EBV-infected "anaplastic" B cell proliferation confined to sinuses.2017

    • Author(s)
      Keisuke Kawasaki, Kennosuke Karube.
    • Journal Title

      Blood

      Volume: 129 Issue: 13 Pages: 1885-1885

    • DOI

      10.1182/blood-2016-11-751974

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-15K08371
  • [Journal Article] Clinicobiological features and prognostic impact of diffuse large B-cell lymphoma component in the outcome of patients with previously untreated follicular lymphoma.2017

    • Author(s)
      Magnano L, Balague O, Dlouhy I, Rovira J, Karube K, Pinyol M, Rivas-Delgado A, Costa D, Martinez-Trillos A, Gonzalez-Farre B, Martinez-Pozo A, Gine; E, Colomer D, Delgado J, Villamor N, Campo E, Lopez-Guillermo A.
    • Journal Title

      Annals Oncology

      Volume: 28 Issue: 11 Pages: 2799-2805

    • DOI

      10.1093/annonc/mdx407

    • Peer Reviewed / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-15K08371
  • [Journal Article] Human T-cell leukemia virus type I Tax genotype analysis in Okinawa, the southernmost and remotest islands of Japan: Different distributions compared with mainland Japan and the potential value for the prognosis of aggressive adult T-cell leukemia/lymphoma2017

    • Author(s)
      Sakihama Shugo、Saito Mineki、Kuba-Miyara Megumi、Tomoyose Takeaki、Taira Naoya、Miyagi Takashi、Hayashi Masaki、Kinjo Shigeko、Nakachi Sawako、Tedokon Iori、Nishi Yukiko、Tamaki Keita、Morichika Kazuho、Uchihara Jun-nosuke、Morishima Satoko、Karube Ken-nosuke、Tanaka Yuetsu、Masuzaki Hiroaki、Fukushima Takuya
    • Journal Title

      Leuk Res

      Volume: 61 Pages: 18-24

    • DOI

      10.1016/j.leukres.2017.08.006

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-17K09839, KAKENHI-PROJECT-15K08371, KAKENHI-PROJECT-15K09345
  • [Journal Article] Comprehensive gene expression profiles of NK cell neoplasms identify vorinostat as an effective drug candidate.2013

    • Author(s)
      Karube K
    • Journal Title

      Cancer Letter

      Volume: (in press)

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-24790987
  • [Journal Article] Lineage-specific growth inhibition of NK cell lines by FOXO3 in association with Akt activation status.2012

    • Author(s)
      Karube K
    • Journal Title

      Experimental Hematology

      Volume: 40

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-24790987
  • [Journal Article] Identification of FOXO3 and PRDM1 as tumor suppressor gene candidates in NK cell neoplasms by genomic and functional analyses2011

    • Author(s)
      Karube K, et al
    • Journal Title

      Blood

      Volume: 118 Issue: 12 Pages: 3195-3204

    • DOI

      10.1182/blood-2011-04-346890

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-22790368
  • [Journal Article] Pathological and immunohistological findings and genetic aberrations of intestinal enteropathy-associated T cell lymphoma in Japan2011

    • Author(s)
      Takeshita M, Nakamura S, Karube K
    • Journal Title

      Histopathology

      Volume: 58(3) Pages: 395-407

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-22790368
  • [Journal Article] Identification of FOXO3 and PRDM1 as tumor suppressor gene candidates in NK cell neoplasms by genomic and functional analyses2011

    • Author(s)
      Karube K, Nakagawa M
    • Journal Title

      Blood

      Volume: 118(12) Pages: 3195-204

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-22790368
  • [Journal Article] Genomic profiling combined with gene expression profiling in primary central nervous system lymphoma2010

    • Author(s)
      Sung CO, Kim SC, Karnan S, Karube K
    • Journal Title

      Blood

      Volume: 117(4) Pages: 1290-300

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-22790368
  • [Journal Article] The International Prognostic Index predicts outcome in aggressive adult T-cell leukemia/lymphoma : analysis of 126 patients from the International Peripheral T-Cell Lymphoma Project2009

    • Author(s)
      Suzumiya J, Ohshima K, Tamura K, Karube K, 他6名
    • Journal Title

      Annals of Oncology 20

      Pages: 715-721

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20890298
  • [Journal Article] Plasmacytoid dendritic cells prime alloreactive T cells to mediate graft-versus-host disease as antigen-presenting cells2009

    • Author(s)
      Koyama M, Hashimoto D, Aoyama K, Matsuoka K, Karube K, 他5名
    • Journal Title

      Blood 113

      Pages: 2088-2095

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20890298
  • [Journal Article] Plasmacytoid dendritic cells prime alloreactive T cells to mediate graft-versus-host disease as antigen presenting cells.2009

    • Author(s)
      Koyama M, Hashimoto D, Aoyama K, Matsuoka K, Karube K (他5名, 5番目)
    • Journal Title

      Blood 113

      Pages: 2088-95

    • Data Source
      KAKENHI-PROJECT-20890298
  • [Journal Article] Hepatocellular apoptosis associated with cytotoxic/natural killer-cell infiltration in chronic active EBV infection.2009

    • Author(s)
      Nomura Y, Kimura H, Karube K, (他11名, 3番目)
    • Journal Title

      Pathol Int. 59

      Pages: 438-42

    • Data Source
      KAKENHI-PROJECT-20890298
  • [Journal Article] The International Prognostic Index predicts outcome in aggressive adult T cell leukemia/lymphoma: analysis of 126 patients from the International peripheral T-cell lymphoma project2009

    • Author(s)
      Suzumiya J, Ohshima K, Tamura K, Karube K, (他6名, 4番目)
    • Journal Title

      Annal Oncol. 20

      Pages: 715-21

    • Data Source
      KAKENHI-PROJECT-20890298
  • [Journal Article] BCL6 gene amplification/3q27 gain is associated with unique clinicopathological characteristics among follicular lymphoma without BCL2 gene translocation2008

    • Author(s)
      Karube K, 他13名
    • Journal Title

      Modern Pathology 21

      Pages: 973-978

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20890298
  • [Presentation] NK細胞性腫瘍に特異的ながん抑制遺伝子であるFOXO3.2012

    • Author(s)
      加留部謙之輔
    • Organizer
      第71回日本癌学会学術総会
    • Place of Presentation
      ロイトン札幌(札幌)
    • Year and Date
      2012-09-19
    • Data Source
      KAKENHI-PROJECT-24790987
  • [Presentation] Genomic and functional analyses of NK-cell neoplasms2012

    • Author(s)
      加留部謙之輔
    • Organizer
      4th T cell lymphoma forum
    • Place of Presentation
      ホテル日航サンフランシスコ(サンフランシスコ)
    • Year and Date
      2012-01-26
    • Data Source
      KAKENHI-PROJECT-22790368
  • [Presentation] 悪生リンパ腫の臨床病理および分子病態の解析.2012

    • Author(s)
      加留部謙之輔
    • Organizer
      第71回日本癌学会学術総会
    • Place of Presentation
      ロイトン札幌(札幌)
    • Year and Date
      2012-09-21
    • Data Source
      KAKENHI-PROJECT-24790987
  • [Presentation] Identification of FOXO3 and PRDM1 as tumor suppressor gene candidates in NK cell neoplasms by the combination of genomic and functional analyses2011

    • Author(s)
      Kennosuke Karube, Masao Nakagawa, Shinobu Tsuzuki, Young-Hyeh Ko, Shigeo Nakamura, Masao Seto
    • Organizer
      第11回国際リンパ腫会議
    • Place of Presentation
      ルルガノ(スイス)
    • Year and Date
      2011-06-16
    • Data Source
      KAKENHI-PROJECT-22790368
  • [Presentation] NK細胞性腫瘍におけるFOXO3およびPRDM1のがん抑制遺伝子としての意義2011

    • Author(s)
      加留部謙之輔,中川雅夫,都築忍,清水則夫,中村栄男,高田尚良,瀬戸加大
    • Organizer
      第70回日本癌学会学術総会ポスター
    • Place of Presentation
      名古屋国際会議場
    • Year and Date
      2011-10-05
    • Data Source
      KAKENHI-PROJECT-22790368
  • [Presentation] The genomic analysis of NK/T cell neoplasms2010

    • Author(s)
      加留部謙之輔
    • Organizer
      第69回日本癌学会学術総会
    • Place of Presentation
      大阪国際会議場(大阪市)
    • Year and Date
      2010-09-22
    • Data Source
      KAKENHI-PROJECT-22790368
  • [Presentation] The gene expression profile of NK/T cell neoplasm(ポスター)2009

    • Author(s)
      Karube K, et al
    • Organizer
      第68回日本癌学会学術総会
    • Place of Presentation
      横浜)
    • Year and Date
      2009-10-02
    • Data Source
      KAKENHI-PROJECT-20890298
  • [Presentation] The gene expression profile of NK/T cell neoplasm2009

    • Author(s)
      加留部, 謙之輔
    • Organizer
      第68回日本癌学会学術総会
    • Place of Presentation
      パシフィコ横浜(横浜市)
    • Year and Date
      2009-10-02
    • Data Source
      KAKENHI-PROJECT-20890298
  • [Presentation] 謙之輔NK/T細胞性腫瘍の遺伝子発現プロファイル(ポスター)2008

    • Author(s)
      加留部
    • Organizer
      第67回日本癌学会学術総会
    • Place of Presentation
      名古屋
    • Year and Date
      2008-10-28
    • Data Source
      KAKENHI-PROJECT-20890298
  • [Presentation] NK/T細胞性腫瘍の遺伝子発現プロファイル2008

    • Author(s)
      加留部, 謙之輔, 他4名
    • Organizer
      第67回日本癌学会学術総会
    • Place of Presentation
      名古屋国際会議場
    • Year and Date
      2008-10-28
    • Data Source
      KAKENHI-PROJECT-20890298
  • 1.  Ishigami Kousei (10403916)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 2.  大島 孝一 (50203766)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 3.  村山 貞之 (60239548)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 4.  伊良波 裕子 (50305207)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 5.  與儀 彰 (80510718)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 6.  齋藤 誠一 (80235043)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 7.  石塚 賢治 (10441742)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 8.  加藤 光次 (20571764)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 1 results
  • 9.  福島 卓也 (40336160)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 10.  佐藤 賢文 (70402807)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 11.  下田 和哉 (90311844)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 12.  Miyawaki Kohta
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 13.  Akashi Koichi
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 14.  益崎 裕章
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results

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