mitunaga sigeki 光永滋樹

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MITSUNAGA Shigeki 光永滋樹

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Researcher Number	20510051
Other IDs
Affiliation (Current)	2025: 国立遺伝学研究所, ゲノム・進化研究系, 特任研究員
Affiliation (based on the past Project Information) *help	2010 – 2012: 東海大学, 医学部, 教授
Review Section/Research Field	Principal Investigator Medical genome science
Keywords	Principal Investigator Exome解析 / Long-Range PCR / 希少変異体 / 次世代シーケンサ / 稀少変異体 / 感受性遺伝子 / エクソーム解析 / 関節リウマチ / 稀少変異 / 疾患関連遺伝子

Exome sequencing for disease gene discovery in rheumatoid arthritisPrincipal Investigator
- Principal Investigator
  
  MITSUNAGA Shigeki
- Project Period (FY)
  2010 – 2012
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Medical genome science
- Research Institution
  Tokai University

All 2013 2012 2011 2010 Other

All Journal Article Presentation

[Journal Article] Exome sequencing identifies novel rheumatoid arthritis-susceptible variants in the BTNL22013
- Author(s)
  Mitsunaga S, Hosomichi K, Okudaira Y, Nakaoka H, Kunii N, Suzuki Y, Kuwana M, Sato S, Kaneko Y, Homma Y, Kashiwase K, Azuma F, Kulski JK, Inoue I, Inoko H.
- Journal Title
  
  J Hum Gene
  
  Volume: 58(4) Pages: 210-5
- NAID
  40019642228
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22510213
[Journal Article] Detection of Ancestry Informative HLA Alleles Confirms the Admixed Origins of Japanese Population2013
- Author(s)
  Nakaoka H, Mitsunaga S, Hosomichi K, Shyh-Yuh L,Sawamoto T, Fujiwara T, Tsutsui N, Suematsu K, Shinagawa A, Inoko H, Inoue I.
- Journal Title
  
  PLoS One
  
  Volume: 8(4)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22510213
[Journal Article] Improved loop-mediated isothermal amplification for HLA-DRB1 genotyping using RecA and a restriction enzyme for enhanced amplification specificity.2013
- Author(s)
  Mitsunaga S, Shimizu S, Okudaira Y, Oka A, Tanaka M, Kimura M, Kulski JK, Inoue I, Inoko H.
- Journal Title
  
  Immunogenetics
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22510213
[Journal Article] Exome sequencing identifies novel rheumatoid arthritis-susceptible variants in the BTNL2.2013
- Author(s)
  Mitsunaga S, Hosomichi K, Okudaira Y, Nakaoka H, Kunii N, Suzuki Y, Kuwana M, Sato S, Kaneko Y, Homma Y, Kashiwase K, Azuma F, Kulski JK, Inoue I, Inoko H.
- Journal Title
  
  J Hum Genet.
  
  Volume: 58 Issue: 4 Pages: 210-215
- DOI
  10.1038/jhg.2013.2
- NAID
  10031169422
- Peer Reviewed
- Data Source
  KAKENHI-PLANNED-22133002, KAKENHI-PROJECT-22510213, KAKENHI-PROJECT-24591456, KAKENHI-PROJECT-221S0002, KAKENHI-PUBLICLY-23133507
[Journal Article] Improved loop-mediated isothermal amplification for HLA-DRB1 genotyping using RecA and a restriction enzyme for enhanced amplification specificity2013
- Author(s)
  Mitsunaga S, Shimizu S, Okudaira Y, Oka A, Tanaka M, Kimura M, Kulski JK, Inoue I, Inoko H
- Journal Title
  
  Immunogenet
  
  Volume: 65(6) Issue: 6 Pages: 405-415
- DOI
  10.1007/s00251-013-0690-0
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22241049, KAKENHI-PROJECT-22510213, KAKENHI-PROJECT-23390191, KAKENHI-PROJECT-24651064
[Journal Article] Detection of ancestry informative HLA alleles confirms the admixed origins of Japanese population.2013
- Author(s)
  Nakaoka H, Mitsunaga S, Hosomichi K, Shyh-Yuh L, Sawamoto T, Fujiwara T, Tsutsui N, Suematsu K, Shinagawa A, Inoko H, Inoue I.
- Journal Title
  
  PLoS One.
  
  Volume: 8 Issue: 4 Pages: e60793-e60793
- DOI
  10.1371/journal.pone.0060793
- Peer Reviewed
- Data Source
  KAKENHI-PLANNED-22133002, KAKENHI-PROJECT-22241049, KAKENHI-PROJECT-22510213, KAKENHI-PROJECT-25860257, KAKENHI-PUBLICLY-23133507
[Journal Article] Super high resolution for single molecule-sequence-based typing of classical HLA loci at the 8-digit level using next generation sequencers.2012
- Author(s)
  Shiina T, Suzuki S, Ozaki Y, Taira H, Kikkawa E, Shigenari A, Oka A, Umemura T, Joshita S, Takahashi O, Hayashi Y, Paumen M, Katsuyama Y, Mitsunaga S, Ota M, Kulski JK, Inoko H.
- Journal Title
  
  Tissue Antigens
  
  Volume: 80(4) Pages: 305-16
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22510213
[Journal Article] Associations between six classical HLA loci and rheumatoid arthritis: a comprehensive analysis.2012
- Author(s)
  Mitsunaga S, Suzuki Y, Kuwana M, Sato S, Kaneko Y, Homma Y, Narita A, Kashiwase K, Okudaira Y, Inoue I, Kulski JK, Inoko H
- Journal Title
  
  Tissue Antigens
  
  Volume: 80(1) Pages: 16-25
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22510213
[Journal Article] Super high resolution for single molecule-sequence-based typing of classical HLA loci at the 8-digit level using next generation sequencers.2012
- Author(s)
  Shiina T, Suzuki S, Ozaki Y, Taira H, Kikkawa E, Shigenari A, Oka A, Umemura T, Joshita S, Takahashi O, Hayashi Y, Paumen M, Katsuyama Y, Mitsunaga S, Ota M, Kulski JK, Inoko H
- Journal Title
  
  Tissue Antigens.
  
  Volume: 80 Issue: 4 Pages: 305-16
- DOI
  10.1111/j.1399-0039.2012.01941.x
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22510213, KAKENHI-PROJECT-22590304, KAKENHI-PROJECT-23390191, KAKENHI-PROJECT-23590969, KAKENHI-PLANNED-22133002
[Journal Article] Exact break point of a 50 kb deletion 8 kb centromeric of the HLA-A locus with HLA-A*24:02: the same deletion observed in other A*24 alleles and A*23:01 allele2011
- Author(s)
  Mitsunaga S, Okudaira Y, Kunii N, Cui T, Hosomichi K, Oka A, Suzuki Y, Homma Y, Sato S, Inoue I, Inoko H
- Journal Title
  
  Immunogenetics
  
  Volume: 63(8) Pages: 467-74
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22510213
[Journal Article] Particular human leukocyte antigen alleles are associated with biochemical traits in the Japanese population2011
- Author(s)
  Mitsunaga Shigeki; Homma Yasuhiko; Narita Akira, et al
- Journal Title
  
  HUMAN IMMUNOLOGY
  
  Volume: 72:7 Issue: 7 Pages: 566-570
- DOI
  10.1016/j.humimm.2011.03.011
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19101008, KAKENHI-PROJECT-22241049, KAKENHI-PROJECT-22510213, KAKENHI-PUBLICLY-23133507, KAKENHI-PROJECT-23390191
[Journal Article] A systems genetics approach provides a bridge from discovered genetic variants to biological pathways in rheumatoid arthritis.2011
- Author(s)
  Nakaoka H, Cui T, Tajima A, Oka A, Mitsunaga S, Kashiwase K, Homma Y, Sato S, Suzuki Y, Inoko H, Inoue I.
- Journal Title
  
  PLoS One
  
  Volume: 6(9)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22510213
[Journal Article] Particular human leukocyte antigen alleles are associated with biochemical traits in the Japanese population2011
- Author(s)
  Mitsunaga S, Homma Y, Narita A, Kashiwase K, Okudaira Y, Shiina Y, Inoue I, Inoko H.
- Journal Title
  
  Hum Immuno
  
  Volume: 72(7) Pages: 566-70
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22510213
[Journal Article] A Systems Genetics Approach Provides a Bridge from Discovered Genetic Variants to Biological Pathways in Rheumatoid Arthritis2011
- Author(s)
  Nakaoka Hirofumi; Cui Tailin; Tajima Atsushi, et al
- Journal Title
  
  PLOS ONE
  
  Volume: 6:9 Issue: 9 Pages: e25389-e25389
- DOI
  10.1371/journal.pone.0025389
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19101008, KAKENHI-PROJECT-22241049, KAKENHI-PROJECT-22510213, KAKENHI-PROJECT-22590304, KAKENHI-PUBLICLY-23133507, KAKENHI-PROJECT-23390191, KAKENHI-PROJECT-23510242, KAKENHI-PROJECT-221S0002
[Journal Article] Genome情報と薬剤応答
- Author(s)
  光永滋樹、猪子英俊
- Journal Title
  
  International Review of Thrombosis
  
  Volume: (印刷中)
- Data Source
  KAKENHI-PROJECT-22510213
[Journal Article] Exact break point of a 50 kb deletion 8 kb centromeric of the HLA-A locus with HLA-A^*24:02 : the same deletion observed in other A^*24 alleles and A^*23:01 allele
- Author(s)
  Shigeki Mitsunaga, Yuko Okudaira, Nanae Kunii, et al.
- Journal Title
  
  Immunogenetics
  
  Volume: (in press)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22510213
[Presentation] 関節リウマチとHLA 6座との関連解析2012
- Author(s)
  奥平裕子、光永滋樹、鈴木康夫、桑名正隆、佐藤慎二、金子祐子、本間康彦、成田暁、柏瀬貢一、井ノ上逸朗、猪子英俊
- Organizer
  第21回日本組織適合性学会大会
- Place of Presentation
  東京明治大学駿河台キャンパス
- Data Source
  KAKENHI-PROJECT-22510213
[Presentation] Integrative analysis of whole-gene co-expression network and exome sequence data to characterize pathways relevant to rheumatoid arthritis.2012
- Author(s)
  Hirofumi Nakaoka, Shigeki Mitsunaga, Hidetoshi Inoko, Ituro Inoue:
- Organizer
  62nd Annual Meeting of the American Society of Human Genetics
- Place of Presentation
  San Francisco, CA
- Data Source
  KAKENHI-PROJECT-22510213
[Presentation] 関節リウマチとHLA 6座との関連解析2012
- Author(s)
  奥平裕子、光永滋樹、鈴木康夫、桑名正隆、佐藤慎二、金子祐子、本間康彦、成田暁、柏瀬貢一、井ノ上逸朗、猪子英俊
- Organizer
  第21回日本組織適合性学会大会
- Place of Presentation
  東京　明治大学駿河台キャンパス
- Data Source
  KAKENHI-PROJECT-22510213
[Presentation] HLA研究の臨床応用を目指した８桁レベルHLAタイピング法の開発2012
- Author(s)
  椎名隆、鈴木進悟、尾崎有紀、吉川枝里、重成敦子、光永滋樹、猪子英俊
- Organizer
  第21回日本組織適合性学会大会
- Place of Presentation
  東京　明治大学駿河台キャンパス
- Data Source
  KAKENHI-PROJECT-22510213
[Presentation] HLA遺伝子における超高解像度DNAタイピング法（SS-SBT法）2012
- Author(s)
  尾崎有紀、鈴木進悟、重成敦子、吉川枝里、岡　晃、光永滋樹、稲岡斉彦、大澤資樹、椎名隆、猪子英俊
- Organizer
  日本DNA多型学会第21回学術集会
- Place of Presentation
  京都　京都教育文化センター
- Data Source
  KAKENHI-PROJECT-22510213
[Presentation] エクソーム解析による関節リウマチ感受性遺伝子の探索2011
- Author(s)
  奥平裕子、光永滋樹、國井七絵、細道一善、田中政之、林英樹、河田寿子、鈴木康夫、佐藤慎二、本間康彦、井ノ上逸朗、猪子英俊
- Organizer
  第34回日本分子生物学会年会
- Place of Presentation
  横浜市パシフィコ横浜
- Year and Date
  2011-12-14
- Data Source
  KAKENHI-PROJECT-22510213
[Presentation] エクソーム解析による関節リウマチ感受性遺伝子の探索2011
- Author(s)
  奥平裕子、光永滋樹、國井七絵、細道一善、田中政之、林英樹、河田寿子、鈴木康夫、佐藤慎二、本間康彦、井ノ上逸朗、猪子英俊
- Organizer
  第34回日本分子生物学会年会
- Place of Presentation
  横浜パシフィコ横浜
- Data Source
  KAKENHI-PROJECT-22510213
[Presentation] 関節リウマチにおけるシステムズ・ジェネティクス・アプローチ~感受性遺伝子座から生物学的経路の推定2011
- Author(s)
  中岡博史, 崔泰林, 田嶋敦, 光永滋樹, 猪子英俊, 井ノ上逸朗
- Organizer
  日本人類遺伝学会第56回大会
- Place of Presentation
  千葉幕張メッセ
- Data Source
  KAKENHI-PROJECT-22510213
[Presentation] 日本人集団におけるHLAと生化学検査値の関連2011
- Author(s)
  奥平裕子、光永滋樹、成田暁、柏瀬貢一、椎名豊、本間康彦、井ノ上逸朗、猪子英俊
- Organizer
  第20回日本組織適合性学会大会
- Place of Presentation
  静岡市ツインメッセ静岡
- Year and Date
  2011-08-29
- Data Source
  KAKENHI-PROJECT-22510213
[Presentation] A*24:02を有するHLA-A遺伝子近傍の欠失領域の解析2010
- Author(s)
  奥平裕子、光永滋樹、崔泰林、河田寿子、細道一善、山口香織、岡晃、井ノ上逸朗、猪子英俊
- Organizer
  第19回日本組織適合性学会大会
- Place of Presentation
  東京東京大学本郷キャンパス
- Data Source
  KAKENHI-PROJECT-22510213
[Presentation] HLA-DRB1*14:54 の分布2010
- Author(s)
  勝山喜彦、太田雅穂、吉川枝里、光永滋樹、益尾清恵、猪子英俊
- Organizer
  第19回日本組織適合性学会大会
- Place of Presentation
  東京東京大学本郷キャンパス
- Data Source
  KAKENHI-PROJECT-22510213
[Presentation] 関節リウマチ感受性遺伝子における希少多型・変異の探索2010
- Author(s)
  國井七絵、光永滋樹, 他
- Organizer
  BMB2010
- Place of Presentation
  神戸ポートアイランド(兵庫県)
- Year and Date
  2010-12-09
- Data Source
  KAKENHI-PROJECT-22510213
[Presentation] 関節リウマチ感受性遺伝子における希少多型・変異の探索2010
- Author(s)
  國井七絵、光永滋樹、細道一善、奥平裕子、鈴木康夫、本間康彦、井ノ上逸朗、猪子英俊
- Organizer
  第33回日本分子生物学会年会・第83回日本生化学会大会合同大会
- Place of Presentation
  神戸ポートアイランド
- Data Source
  KAKENHI-PROJECT-22510213
[Presentation] 関節リウマチの病型とHLAとの関連解析2010
- Author(s)
  國井七絵、光永滋樹、奥平裕子、成田暁、鈴木康夫、本間康彦、桑名正隆、柏瀬貢一、井ノ上逸朗、猪子英俊
- Organizer
  第19回日本組織適合性学会大会
- Place of Presentation
  東京東京大学本郷キャンパス
- Data Source
  KAKENHI-PROJECT-22510213
[Presentation] A systematic approach to constructing genomic risk prediction model of common disease and assessing its clinical validity: A case study of rheumatoid arthritis2010
- Author(s)
  中岡博史, 崔泰林, 田嶋敦, 光永滋樹, 井ノ上逸朗
- Organizer
  第33回日本分子生物学会年会・第83回日本生化学会大会合同大会
- Place of Presentation
  神戸ポートアイランド
- Data Source
  KAKENHI-PROJECT-22510213

1. INOKO Hidetoshi (10101932)

# of Collaborated Projects: 1 results

# of Collaborated Products: 27 results
2. INOUE Ituro (00192500)

# of Collaborated Projects: 1 results

# of Collaborated Products: 19 results
3. SHIINA Takashi (00317744)

# of Collaborated Projects: 1 results

# of Collaborated Products: 8 results
4. HOSOMICHI Kazuyoshi

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results
5. OKA Akira

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

mitunaga sigeki 光永 滋樹

MITSUNAGA Shigeki 光永 滋樹

Research Projects

Research Products

Co-Researchers

Exome sequencing for disease gene discovery in rheumatoid arthritisPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] Exome sequencing identifies novel rheumatoid arthritis-susceptible variants in the BTNL22013

Author(s)

Journal Title

NAID

Data Source

[Journal Article] Detection of Ancestry Informative HLA Alleles Confirms the Admixed Origins of Japanese Population2013

Author(s)

Journal Title

Data Source

[Journal Article] Improved loop-mediated isothermal amplification for HLA-DRB1 genotyping using RecA and a restriction enzyme for enhanced amplification specificity.2013

Author(s)

Journal Title

Data Source

[Journal Article] Exome sequencing identifies novel rheumatoid arthritis-susceptible variants in the BTNL2.2013

Author(s)

Journal Title

DOI

NAID

Data Source

[Journal Article] Improved loop-mediated isothermal amplification for HLA-DRB1 genotyping using RecA and a restriction enzyme for enhanced amplification specificity2013

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Detection of ancestry informative HLA alleles confirms the admixed origins of Japanese population.2013

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Super high resolution for single molecule-sequence-based typing of classical HLA loci at the 8-digit level using next generation sequencers.2012

Author(s)

Journal Title

Data Source

[Journal Article] Associations between six classical HLA loci and rheumatoid arthritis: a comprehensive analysis.2012

Author(s)

Journal Title

Data Source

[Journal Article] Super high resolution for single molecule-sequence-based typing of classical HLA loci at the 8-digit level using next generation sequencers.2012

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Exact break point of a 50 kb deletion 8 kb centromeric of the HLA-A locus with HLA-A*24:02: the same deletion observed in other A*24 alleles and A*23:01 allele2011

Author(s)

Journal Title

Data Source

[Journal Article] Particular human leukocyte antigen alleles are associated with biochemical traits in the Japanese population2011

Author(s)

Journal Title

DOI

Data Source

[Journal Article] A systems genetics approach provides a bridge from discovered genetic variants to biological pathways in rheumatoid arthritis.2011

Author(s)

Journal Title

Data Source

[Journal Article] Particular human leukocyte antigen alleles are associated with biochemical traits in the Japanese population2011

Author(s)

Journal Title

Data Source

[Journal Article] A Systems Genetics Approach Provides a Bridge from Discovered Genetic Variants to Biological Pathways in Rheumatoid Arthritis2011

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Genome情報と薬剤応答

Author(s)

Journal Title

Data Source

[Journal Article] Exact break point of a 50 kb deletion 8 kb centromeric of the HLA-A locus with HLA-A^*24:02 : the same deletion observed in other A^*24 alleles and A^*23:01 allele

mitunaga sigeki 光永滋樹

MITSUNAGA Shigeki 光永滋樹

[Journal Article] Exact break point of a 50 kb deletion 8 kb centromeric of the HLA-A locus with HLA-A24:02: the same deletion observed in other A24 alleles and A*23:01 allele2011

[Journal Article] Exact break point of a 50 kb deletion 8 kb centromeric of the HLA-A locus with HLA-A^24:02 : the same deletion observed in other A^24 alleles and A^*23:01 allele