Saegusa Jun 三枝淳

… Alternative Names

SAEGUSA Jun 三枝淳

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Researcher Number	20514970
Other IDs
Affiliation (Current)	2025: 神戸大学, 医学研究科, 准教授
Affiliation (based on the past Project Information) *help	2021 – 2024: 神戸大学, 医学研究科, 准教授 2020: 神戸大学, 医学部附属病院, 准教授 2013 – 2019: 神戸大学, 医学部附属病院, 講師 2011 – 2012: 神戸大学, 医学部附属病院, 助教 2011: 神戸大学, 医学部附属病院, 特定助教 2008 – 2010: Kobe University, 医学研究科, 特命助教 2008 – 2009: 神戸大学, 大学院・医学研究科, 特命助教
Review Section/Research Field	Principal Investigator Basic Section 54020:Connective tissue disease and allergy-related / 膠原病・アレルギー・感染症内科学 / Collagenous pathology/Allergology Except Principal Investigator Collagenous pathology/Allergology / Basic Section 54020:Connective tissue disease and allergy-related / Basic Section 58010:Medical management and medical sociology-related / Laboratory medicine
Keywords	Principal Investigator 関節リウマチ / 滑膜細胞 / 全身性自己免疫疾患 / 自己免疫疾患 / 代謝 / グルタミノリシス / グルタミン代謝 / メタボロミクス / 膠原病 / バイオマーカー … More / インテグリン / iPS細胞 / CD4陽性T細胞 / 炎症性筋疾患 / ANCA関連血管炎 / 細胞外小胞 / エクソソーム / ラパマイシン / マウス関節炎モデル / クロロキン / オートファジー / グルタミナーゼ１ / 解糖系 / グルタミン酸 / ガスクロマトグラフィー質量分析計 / 全身性エリテマトーデス / メタボローム解析 / 細胞増殖因子 / 増殖因子 / サイトカイン / インターロイキン-1 … More Except Principal Investigator 関節リウマチ / マイクロRNA / アジュバント関節炎 / エクソソーム / QOL / 主観的幸福度 / ノンコーディングRNA / 長鎖ノンコーディングRNA / 長鎖ノンコーディングRNA / 滑膜細胞 / 核酸 / 免疫学 / miRNA / リウマチ学 / マイクロＲＮＡ / 破骨細胞 / 蛍光相関分光法 / 生物製剤 / 転写因子 / 自己免疫疾患 Less

Analysis of autoreactive T cells in rheumatoid arthritis using iPS cell technologyPrincipal Investigator
- Principal Investigator
  
  三枝淳
- Project Period (FY)
  2024 – 2026
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 54020:Connective tissue disease and allergy-related
- Research Institution
  Kobe University
Development of a novel diagnostic and therapeutic strategy for systemic autoimmune diseases focusing on extracellular vesiclesPrincipal Investigator
- Principal Investigator
  
  Saegusa Jun
- Project Period (FY)
  2021 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 54020:Connective tissue disease and allergy-related
- Research Institution
  Kobe University
The fluctuation in subjective well-being of patients with early rheumatoid arthritis
- Principal Investigator
  
  蔭山豪一
- Project Period (FY)
  2020 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 58010:Medical management and medical sociology-related
- Research Institution
  Hyogo Prefectural Amagasaki General Medical Center
Inetraction of non-coding RNA specific for rheumatoid arthritis
- Principal Investigator
  
  KAWANO SEIJI
- Project Period (FY)
  2019 – 2021
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 54020:Connective tissue disease and allergy-related
- Research Institution
  Kobe University
Development of novel therapeutic strategies targeting cellular metabolism in autoimmune diseasesPrincipal Investigator
- Principal Investigator
  
  Saegusa Jun
- Project Period (FY)
  2018 – 2020
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 54020:Connective tissue disease and allergy-related
- Research Institution
  Kobe University
Role of exosomes in the pathology of rheumatoid arthritis
- Principal Investigator
  
  Nakamachi Yuji
- Project Period (FY)
  2018 – 2020
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 54020:Connective tissue disease and allergy-related
- Research Institution
  Kobe University
Study of target molecules of rheumatoid arthritis-associated miRNA.
- Principal Investigator
  
  Kawano Seiji
- Project Period (FY)
  2016 – 2018
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Collagenous pathology/Allergology
- Research Institution
  Kobe University
A metabolic approach for discovering therapeutic target in rheumatoid arthritis synovial fibroblastPrincipal Investigator
- Principal Investigator
  
  Saegusa Jun
- Project Period (FY)
  2015 – 2017
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Collagenous pathology/Allergology
- Research Institution
  Kobe University
Development of the novel therapy for rheumatoid arthritis by micro RNA-containing exosomes
- Principal Investigator
  
  Nakamachi Yuji
- Project Period (FY)
  2015 – 2017
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Collagenous pathology/Allergology
- Research Institution
  Kobe University
Study of the role of miRNA in the regulation of osteoclast differentiation in rheunmatoid arthritis joints
- Principal Investigator
  
  Kawano Seiji
- Project Period (FY)
  2013 – 2015
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Collagenous pathology/Allergology
- Research Institution
  Kobe University
Metabolomics for biomarker discovery in systemic lupus erythematosusPrincipal Investigator
- Principal Investigator
  
  SAEGUSA Jun
- Project Period (FY)
  2012 – 2014
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  膠原病・アレルギー・感染症内科学
- Research Institution
  Kobe University
Development of a novel therapeutic method for rheumatoid arthritis by targeting growth factor signalingPrincipal Investigator
- Principal Investigator
  
  SAEGUSA Jun
- Project Period (FY)
  2010 – 2011
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  膠原病・アレルギー・感染症内科学
- Research Institution
  Kobe University
Analysis of signaling pathways induced by the binding of IL-1・to integrinsPrincipal Investigator
- Principal Investigator
  
  SAEGUSA Jun
- Project Period (FY)
  2008 – 2009
- Research Category
  
  Grant-in-Aid for Young Scientists (Start-up)
- Research Field
  
  膠原病・アレルギー・感染症内科学
- Research Institution
  Kobe University
Development of a new assay system for transcription factor activity using FCS
- Principal Investigator
  
  KUMAGAI Shunichi
- Project Period (FY)
  2007 – 2009
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Laboratory medicine
- Research Institution
  Kobe University

[Book] 最新関節リウマチ学2014
- Author(s)
  三枝淳，松木郁親，森信暁雄
- Total Pages
  5
- Publisher
  日本臨牀社
- Data Source
  KAKENHI-PROJECT-24591445
[Book] Galectins in Regulation of Inflammation and Immunity. In: Galectins.2008
- Author(s)
  L iu FT, Hsu DK, Yang RY, Chen HY, Saegusa J.
- Publisher
  Oxford University Press
- Data Source
  KAKENHI-PROJECT-20890126
[Journal Article] Identification of plexin D1 on circulating extracellular vesicles as a potential biomarker of polymyositis and dermatomyositis2022
- Author(s)
  Uto K, Ueda K, Okano T, Akashi K, Takahashi S, Nakamachi Y, Imanishi T, Awano H, Morinobu A, Kawano S, and Saegusa J.
- Journal Title
  
  Rheumatology
  
  Volume: 61 Issue: 4 Pages: 1669-1679
- DOI
  10.1093/rheumatology/keab588
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19K08906, KAKENHI-PROJECT-21K08437
[Journal Article] Additive effects of inhibiting both mTOR and glutamine metabolism on the arthritis in SKG mice2019
- Author(s)
  Ueda Yo、Saegusa Jun、Okano Takaichi、Sendo Sho、Yamada Hirotaka、Nishimura Keisuke、Morinobu Akio
- Journal Title
  
  Scientific Reports
  
  Volume: 9 Issue: 1 Pages: 6374-6374
- DOI
  10.1038/s41598-019-42932-1
- NAID
  120006624233
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K08387, KAKENHI-PROJECT-16K19599
[Journal Article] S100A12 facilitates osteoclast differentiation from human monocytes2018
- Author(s)
  Nishida Miwa、Saegusa Jun、Tanaka Shino、Morinobu Akio
- Journal Title
  
  PLOS ONE
  
  Volume: 13 Issue: 9 Pages: e0204140-e0204140
- DOI
  10.1371/journal.pone.0204140
- NAID
  120006529678
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K08387
[Journal Article] Immunometabolism in rheumatoid arthritis2018
- Author(s)
  Okano Takaichi、Saegusa Jun、Takahashi Soshi、Ueda Yo、Morinobu Akio
- Journal Title
  
  Immunological Medicine
  
  Volume: 41 Issue: 3 Pages: 89-97
- DOI
  10.1080/25785826.2018.1531186
- NAID
  120006840208
- Open Access
- Data Source
  KAKENHI-PROJECT-18K08387
[Journal Article] Myeloid-derived suppressor cells in non-neoplastic inflamed organs2018
- Author(s)
  Sendo Sho、Saegusa Jun、Morinobu Akio
- Journal Title
  
  Inflammation and Regeneration
  
  Volume: 38 Issue: 1
- DOI
  10.1186/s41232-018-0076-7
- NAID
  120006539277
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K08387, KAKENHI-PROJECT-16K09893
[Journal Article] Cardiac Dysfunction in Duchenne Muscular Dystrophy Is Less Frequent in Patients With Mutations in the Dystrophin Dp116 Coding Region Than in Other Regions2018
- Author(s)
  Yamamoto Tetsushi、Awano Hiroyuki、Zhang Zhujun、Sakuma Mio、Kitaaki Shoko、Matsumoto Masaaki、Nagai Masashi、Sato Itsuko、Imanishi Takamitsu、Hayashi Nobuhide、Matsuo Masafumi、Iijima Kazumoto、Saegusa Jun
- Journal Title
  
  Circulation: Genomic and Precision Medicine
  
  Volume: 11 Issue: 1
- DOI
  10.1161/circgen.117.001782
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K08387
[Journal Article] MicroRNA-124 inhibits TNF-α- and IL-6-induced osteoclastogenesis2018
- Author(s)
  Ohnuma Kenichiro、Kasagi Shimpei、Uto Kenichi、Noguchi Yoriko、Nakamachi Yuji、Saegusa Jun、Kawano Seiji
- Journal Title
  
  Rheumatology International
  
  Volume: 39 Issue: 4 Pages: 689-695
- DOI
  10.1007/s00296-018-4218-7
- NAID
  120006629301
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K08387, KAKENHI-PROJECT-16K09894
[Journal Article] CD11b+ Gr1dim tolerogenic dendritic cell-like cells are expanded in interstitial lung disease in SKG mice.2017
- Author(s)
  Sendo S, Saegusa J, Okano T, Takahashi S, Akashi K, Morinobu A.
- Journal Title
  
  Arthritis Rheumatol.
  
  Volume: 69 Issue: 12 Pages: 2314-27
- DOI
  10.1002/art.40231
- NAID
  120006621623
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-15K09525, KAKENHI-PROJECT-16K09893
[Journal Article] 3-bromopyruvate ameliorate autoimmune arthritis by modulating Th17/Treg cell differentiation and suppressing dendritic cell activation.2017
- Author(s)
  Okano T, Saegusa J, Nishimura K, Takahashi S, Sendo S, Ueda Y, Morinobu A.
- Journal Title
  
  Sci Rep.
  
  Volume: 7 Issue: 1 Pages: 42412-42412
- DOI
  10.1038/srep42412
- NAID
  120006624239
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-16K09893, KAKENHI-PROJECT-15K09525
[Journal Article] Direct binding to integrins and loss of disulfide linkage in IL-1beta are involved in the agonistic action of IL-1beta.2017
- Author(s)
  Takada YK, Yu J, Fujita M, Saegusa J, Wu CY, Takada Y.
- Journal Title
  
  J Biol Chem.
  
  Volume: 292 Issue: 49 Pages: 20067-75
- DOI
  10.1074/jbc.m117.818302
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-15K09525
[Journal Article] Glutaminase 1 plays a key role in the cell growth of fibroblast-like synoviocytes in rheumatoid arthritis.2017
- Author(s)
  Takahashi S, Saegusa J, Sendo S, Okano T, Akashi K, Irino Y, Morinobu A
- Journal Title
  
  Arthritis Res Ther.
  
  Volume: 19 Issue: 1 Pages: 76-76
- DOI
  10.1186/s13075-017-1283-3
- NAID
  120006318800
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-16K09893, KAKENHI-PROJECT-15K09525
[Journal Article] Knockout of endothelin type B receptor signaling attenuates bleomycin-induced skin sclerosis in mice.2016
- Author(s)
  Akashi K, Saegusa J, Sendo S, Nishimura K, Okano T, Yagi K, Yanagisawa M, Emoto N, Morinobu A.
- Journal Title
  
  Arthritis Res Ther.
  
  Volume: 18 Issue: 1 Pages: 113-113
- DOI
  10.1186/s13075-016-1011-4
- NAID
  120007135444
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-15K09525, KAKENHI-PROJECT-16K19599
[Journal Article] メタボロームに着目した膠原病の新規治療法および診断法の開発2016
- Author(s)
  三枝淳, 蔭山豪一, 森信暁雄
- Journal Title
  
  アレルギーの臨床
  
  Volume: 36 Pages: 1292-1297
- Data Source
  KAKENHI-PROJECT-15K09525
[Journal Article] MicroRNA-124: a promising therapeutic agent for various human diseases, including rheumatoid arthritis2016
- Author(s)
  Nakamachi Y, Saegusa J, and Kawano S
- Journal Title
  
  RNA & Disease
  
  Volume: ３ Pages: 1-7
- DOI
  10.14800/rd.1252
- Open Access
- Data Source
  KAKENHI-PROJECT-16K09894
[Journal Article] Expression and Functions of Immediate Early Response Gene X-1 (IEX-1) in Rheumatoid Arthritis Synovial Fibroblasts.2016
- Author(s)
  Morinobu A, Tanaka S, Nishimura K, Takahashi S, Kageyama G, Miura Y, Kurosaka M, Saegusa J, Kumagai S.
- Journal Title
  
  PLoS One
  
  Volume: 11 Issue: 10 Pages: e0164350-e0164350
- DOI
  10.1371/journal.pone.0164350
- NAID
  120005898575
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-15K09525, KAKENHI-PROJECT-16K19599
[Journal Article] メタボロームに着目した膠原病の新規治療法および診断法の開発2015
- Author(s)
  三枝淳, 蔭山豪一, 森信暁雄
- Journal Title
  
  BIO Clinica
  
  Volume: 30(11) Pages: 1110-1115
- Data Source
  KAKENHI-PROJECT-15K09525
[Journal Article] Tofacitinib facilitates the expansion of myeloid-derived suppressor cells and ameliorates arthritis in SKG mice.2015
- Author(s)
  Nishimura K, Saegusa J, Matsuki F, Akashi K, Kageyama G, Morinobu A
- Journal Title
  
  Arthritis Rheumatol
  
  Volume: 67 Issue: 4 Pages: 893-902
- DOI
  10.1002/art.39007
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24591445, KAKENHI-PROJECT-15K09525
[Journal Article] MicroRNA-124 inhibits the progression of adjuvant-induced arthritis in rats.2015
- Author(s)
  Nakamachi Y, Ohnuma K, Uto K, Noguchi Y, Saegusa J, Kawano S
- Journal Title
  
  Ann Rheum Dis
  
  Volume: 印刷中 Issue: 3 Pages: 601-608
- DOI
  10.1136/annrheumdis-2014-206417
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-24591445, KAKENHI-PROJECT-25461476, KAKENHI-PROJECT-15K09525
[Journal Article] 自己免疫疾患のメタボローム解析の未来～新規バイオマーカーの同定と病態解明を目指して～2015
- Author(s)
  三枝淳, 河野誠司, 森信暁雄
- Journal Title
  
  臨床病理
  
  Volume: 63(4) Pages: 498-505
- Data Source
  KAKENHI-PROJECT-15K09525
[Journal Article] Metabolomics analysis of saliva from patients with primary Sjogren's syndrome.2015
- Author(s)
  Kageyama G, Saegusa J, Irino Y, Tanaka S, Tsuda K, Takahashi S, Sendo S, Morinobu A.
- Journal Title
  
  Clinical & Experimental Immunology
  
  Volume: 182(2) Issue: 2 Pages: 149-153
- DOI
  10.1111/cei.12683
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-15K09525
[Journal Article] 自己免疫疾患のメタボローム解析の未来～新規バイオマーカーの同定と病態解明を目指して～2015
- Author(s)
  三枝淳、河野誠司、森信暁雄
- Journal Title
  
  臨床病理
  
  Volume: 63 Pages: 498-505
- Data Source
  KAKENHI-PROJECT-24591445
[Journal Article] GC/MS-based metabolomics detects metabolic alterations in serum from SLE patients.2014
- Author(s)
  Saegusa J, Irino Y, Yoshida M, Tanaka S, Kogata Y, Kageyama G, Tsuji G, Takenawa T, Kawano S, Kumagai S, Morinobu A
- Journal Title
  
  Clin Exp Rheumatol
  
  Volume: 32 Pages: 148-148
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24591445
[Journal Article] CD45RA－Foxp3low non-regulatory T cells in the CCR7-CD45RA-CD27+CD28+ effector memory subset are increased in synovial fluid from patients with rheumatoid arthritis2014
- Author(s)
  Matsuki F, Saegusa J, Nishimura K, Miura Y, Kurosaka M, Kumagai S, Morinobu A
- Journal Title
  
  Cell Immunol
  
  Volume: 290 Issue: 1 Pages: 96-101
- DOI
  10.1016/j.cellimm.2014.05.011
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24591445
[Journal Article] Podoplanin is an inflammatory protein upregulated in Th17 cells in SKG arthritic joints2013
- Author(s)
  Miyamoto Y, Uga H, Tanaka S, Kadowaki M, Ikeda M, Saegusa J, Morinobu A, Kumagai S, Kurata H
- Journal Title
  
  Mol Immunol
  
  Volume: 54(2) Pages: 199-207
- Data Source
  KAKENHI-PROJECT-22790929
[Journal Article] Podoplanin is an inflammatory protein upregulated in Th17 cells in SKG arthritic joints.2013
- Author(s)
  Miyamoto Y, Uga H, Tanaka S, Kadowaki M, Ikeda M, Saegusa J, Morinobu A, Kumagai S, Kurata H.
- Journal Title
  
  Mol Immunol.
  
  Volume: 54 Issue: 2 Pages: 199-207
- DOI
  10.1016/j.molimm.2012.11.013
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24591445, KAKENHI-PROJECT-24659473
[Journal Article] Mycophenolate mofetil versus intravenous cyclophosphamide for induction treatment of proliferative lupus nephritis in a Japanese population: a retrospective study2013
- Author(s)
  Onishi A, Sugiyama D, Tsuji G, Nakazawa T, Kogata Y, Tsuda K, Naka I, Nishimura K, Misaki K, Kurimoto C, Hayashi H, Kageyama G, Saegusa J, Sugimoto T, Kawano S, Kumagai S, Morinobu A
- Journal Title
  
  Mod Rheumatol
  
  Volume: 23(1) Issue: 1 Pages: 89-96
- DOI
  10.1007/s10165-012-0634-9
- NAID
  10031167670
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23790967, KAKENHI-PROJECT-24591445
[Journal Article] CD45RA-Foxp3high activated/effector regulatory T cells in the CCR7+CD45RA-CD27+CD28+ central memory subset are decreased in peripheral blood from patients with rheumatoid arthritis.2013
- Author(s)
  23. Matsuki F, Saegusa J, Miyamoto Y, Misaki K, Kumagai S, Morinobu A
- Journal Title
  
  Biochem Biophys Res Commun
  
  Volume: 438 Issue: 4 Pages: 778-183
- DOI
  10.1016/j.bbrc.2013.05.120
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24591445, KAKENHI-PROJECT-24659473
[Journal Article] Mycophenolate mofetil versus intravenous cyclophosphamide for induction treatment of proliferative lupus nephritis in a Japanese population: a retrospective study2013
- Author(s)
  Onishi A, Sugiyama D, Tsuji G, Nakazawa T, Kogata Y, Tsuda K, Naka I, Nishimura K, Misaki K, Kurimoto C, Hayashi H, Kageyama G, Saegusa J, Sugimoto T, Kawano S, Kumagai S, Morinobu A
- Journal Title
  
  Mod Rheumatol
  
  Volume: 23(1) Pages: 89-96
- NAID
  10031167670
- Data Source
  KAKENHI-PROJECT-22790929
[Journal Article] Tumor necrosis factor-α inhibitor-induced antiglomerular basement membrane antibody disease in a patient with rheumatoid arthritis.2012
- Author(s)
  Nishimura K, Saegusa J, Kawano S, Morinobu A.
- Journal Title
  
  J Rheumatol.
  
  Volume: 39 Issue: 9 Pages: 1904-5
- DOI
  10.3899/jrheum.120325
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24591445
[Journal Article] A Dominant-Negative FGF1 Mutant (the R50E Mutant) Suppresses Tumorigenesis and Angiogenesis.2012
- Author(s)
  Mori S.
- Journal Title
  
  PLoS One.
  
  Volume: 8(2) Issue: 2 Pages: 20-36
- DOI
  10.1371/journal.pone.0057927
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23390300, KAKENHI-PROJECT-23590446, KAKENHI-PROJECT-23659611, KAKENHI-PROJECT-24591445
[Journal Article] SS-A/Ro52 promotes apoptosis by regulating Bcl-2 production2012
- Author(s)
  Jauharoh SNA, Saegusa J, Sugimoto T, Ardianto B, Kasagi S, Sugiyama D, Kurimoto C, Tokuno O, Nakamachi Y, Kumagai S, Kawano S
- Journal Title
  
  Biochem Biophys Res Commun
  
  Volume: 417(1) Pages: 582-7
- Data Source
  KAKENHI-PROJECT-22790929
[Journal Article] Diagnostic Accuracy of Serum 1,3-β-D-Glucan for Pneumocystis Jiroveci Pneumonia, Invasive Candidiasis and Invasive Aspergillosis: Systematic Review and Meta-Analysis2012
- Author(s)
  Onishi A, Sugiyama D, Kogata Y, Saegusa J, Sugimoto T, Kawano S, Morinobu A, Nishimura K, Kumagai S
- Journal Title
  
  J Clin Microbiol
  
  Volume: 50(1) Pages: 7-15
- NAID
  120005323616
- Data Source
  KAKENHI-PROJECT-22790929
[Journal Article] Anti TNF-α agent-induced anti-GBM antibody disease in a patient with rheumatoid arthritis2012
- Author(s)
  Nishimura K, Saegusa J, Kawano S, Morinobu A
- Journal Title
  
  J Rheumatol
  
  Volume: 39(9) Pages: 1904-5
- Data Source
  KAKENHI-PROJECT-22790929
[Journal Article] Role of imaging studies in the diagnosis and evaluation of giant cell arteritis in Japanese: report of eight cases2011
- Author(s)
  Morinobu A, Tsuji G, Kasagi S, Saegusa J, Hayashi H, Nakazawa T, Kogata Y, Misaki K, Nishimura K, Sendo S, Miura N, Kawano S, Kumagai S
- Journal Title
  
  Mod Rheumatol
  
  Volume: 21(4) Pages: 391-6
- NAID
  10029512930
- Data Source
  KAKENHI-PROJECT-22790929
[Journal Article] Plasma Platelet-derived Microparticles in Patients with Connective Tissue Diseases2011
- Author(s)
  Oyabu C, Morinobu A, Sugiyama D, Saegusa J, Tanaka S, Morinobu S, Tsuji G, Kasagi S, Kawano S, Kumagai S
- Journal Title
  
  J Rheumatol
  
  Volume: 38(4) Pages: 680-4
- Data Source
  KAKENHI-PROJECT-22790929
[Journal Article] Galectin-3 and the skin2011
- Author(s)
  Larsen L, Chen HY, Saegusa J, Liu FT
- Journal Title
  
  J Dermatol Sci
  
  Volume: 64(2) Pages: 85-91
- NAID
  10030893120
- Data Source
  KAKENHI-PROJECT-22790929
[Journal Article] Nonbacterial thrombotic endocarditis associated with cancer of unknown origin complicated with thrombus in the left auricular appendage: case report.2011
- Author(s)
  Norisada K, Tanaka H, Onishi T, Kaneko A, Tsuji T, Yamawaki K, Ryo K, Tatsumi K, Matsumoto K, Miura N, Saegusa J, Morinaga Y, Hara S, Kawai H, Hirata K
- Journal Title
  
  Cardiovasc Ultrasound
  
  Volume: 9 Pages: 8-8
- Data Source
  KAKENHI-PROJECT-22790929
[Journal Article] Galectins in regulation of apoptosis2011
- Author(s)
  Liu FT, Yang RY, Saegusa J, Chen HY, Hsu DK
- Journal Title
  
  Adv Exp Med Biol
  
  Volume: 705 Pages: 431-42
- Data Source
  KAKENHI-PROJECT-22790929
[Journal Article] Histone deacetylase inhibition alters dendritic cells to assume a tolerogenic phenotype and ameliorates arthritis in SKG mice2011
- Author(s)
  Misaki K, Morinobu A, Saegusa J, Kasagi S, Fujita M, Miyamoto Y, Matsuki F, Kumagai S
- Journal Title
  
  Arthritis Res Ther
  
  Volume: 13(3)
- Data Source
  KAKENHI-PROJECT-22790929
[Journal Article] Epidural spinal tumor and periaortitis as rare complications of Wegener's granulomatosis2011
- Author(s)
  Kasagi S, Saegusa J, Tsuji G, Sendo S, Miura N, Hayashi H, Sugimoto T, Kawano S, Nishida K, Kakutani K, Morinobu A, Kumagai S
- Journal Title
  
  Mod Rheumatol
  
  Volume: 21(6) Pages: 678-83
- NAID
  10030206372
- Data Source
  KAKENHI-PROJECT-22790929
[Journal Article] T cell-binding fragment of fibrinogen can prevent autoimmunity.2010
- Author(s)
  Takada Y, Ono Y, Saegusa J, Mitsiades C, Mitsiades N, Tsai J, He Y, Maningding E, Coleman A, Ramirez-Maverakis D, Rodriquez R, Takada Y, Maverakis E. A
- Journal Title
  
  J Autoimmun
  
  Volume: 34(4) Pages: 453-9
- Data Source
  KAKENHI-PROJECT-22790929
[Journal Article] A T cell-binding fragment of fibrinogen can prevent autoimmunity.2010
- Author(s)
  Takada Y, Ono Y, Saegusa J, Mitsiades C, Mitsiades N, Tsai J, He Y, Maningding E, Coleman A, Ramirez-Maverakis D, Rodriquez R, Takada Y, Maverakis E.
- Journal Title
  
  J Autoimmun. 34(4)
  
  Pages: 453-9
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20890126
[Journal Article] A novel fibroblast growth factor-1 (FGF1) mutant that acts as an FGF antagonist2010
- Author(s)
  Yamaji S, Saegusa J, Ieguchi K, Fujita M, Takada YK, Takada Y
- Journal Title
  
  PLoS One
  
  Volume: 5(4)
- Data Source
  KAKENHI-PROJECT-22790929
[Journal Article] A novel fibroblast growth factor-1 (FGF1) mutant that acts as an FGF antagonist.2010
- Author(s)
  Y amaji S, Saegusa J, Ieguchi K, Fujita M, Takada YK, Takada Y.
- Journal Title
  
  PLoS One. 5(4)
  
  Pages: 10273-10273
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20890126
[Journal Article] The direct binding of insulin-like growth factor-1 (IGF-1) to integrin・v・3 is involved in IGF-1 signaling.2009
- Author(s)
  Saegusa J, Yamaji S, Ieguchi K, Wu CY, Lam KS, Liu FT, Takada YK, Takada Y.
- Journal Title
  
  J Biol Chem. 284(36)
  
  Pages: 24106-14
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20890126
[Journal Article] Galectin-3 is critical for the development of the allergic inflammatory response in a mouse model of atopic dermatitis.2009
- Author(s)
  Saegusa J, Hsu DK, Chen HY, Yu L, Fermin A, Fung MA, Liu FT.
- Journal Title
  
  Am J Pathol. 174(3)
  
  Pages: 922-31
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20890126
[Journal Article] Galectin-3 is critical for the development of the allergic inflammatory response in a mouse model of atopic dermatitis.2009
- Author(s)
  Saegusa J
- Journal Title
  
  Am J Pathol. 174
  
  Pages: 922-31
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20890126
[Journal Article] The direct binding of insulin-like growth factor-1(IGF-1)to integrin alphavbeta3 is involved in IGF-1 signaling2009
- Author(s)
  Saegusa J
- Journal Title
  
  J Biol Chem. 284
  
  Pages: 24106-14
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20890126
[Journal Article] Galectin-3 protects keratinocytes from UVB-induced apoptosis by enhancing AKT activation and suppressing ERK activation.2008
- Author(s)
  Saegusa J, Hsu DK, Liu W, Kuwabara I, Kuwabara Y, Yu L, Liu FT.
- Journal Title
  
  J Invest Dermatol. 128(10)
  
  Pages: 2403-11
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20890126
[Journal Article] Pro-inflammatory secretory phospholipase A2 type IIA binds to integrins・v・3 and・4・1 and induces proliferation of monocytic cells in an integrin-dependent manner.2008
- Author(s)
  Saegusa J, Akakura N, Wu CY, Hoogland C, Ma Z, Lam KS, Liu FT, Takada Y K, Takada Y.
- Journal Title
  
  J Biol Chem. 283(38)
  
  Pages: 26107-15
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20890126
[Journal Article] Pro-inflammatory secretory phospholipase A2 type IIA binds to integrins alphavbeta3 and alpha4betal and induces proliferation of monocytic cells in an integrin-dependent manner2008
- Author(s)
  Saegusa J
- Journal Title
  
  J Biol Chem 283
  
  Pages: 26107-15
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20890126
[Journal Article] Galectin-3 protects keratinocytes from UVB-induced apoptosis by enhancing AKT activation and suppressing ERK activation.2008
- Author(s)
  Saegusa J
- Journal Title
  
  J Invest Dermatol 128
  
  Pages: 2403-11
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20890126
[Journal Article] Is SS-A/Ro52 a hydrogen peroxide-sensitive signaling molecule?2007
- Author(s)
  Nobuhara Y, Kawano S, Kageyama G, Sugiyama D, Saegusa J, Kumagai S
- Journal Title
  
  Antioxid Redox Signal, 9(3)
  
  Pages: 385-91
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19390155
[Journal Article] Is SS-A/Ro52 a hydrogen peroxide-sensitive signaling molecule?2007
- Author(s)
  Nobuhara Y, Kawano S, Kageyama G, Sugiyama D, Saegusa J, Kumagai S.
- Journal Title
  
  Antioxid Redox Signal 9(3)
  
  Pages: 385-91
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19390155
[Presentation] 76.Identification of Plexin D1 on Circulating Extracellular Vesicles as a Potential Biomarker of Polymyositis and Dermatomyositis.2021
- Author(s)
  Uto K, Ueda K, Okano T, Akashi K, Takahashi S, Nakamachi Y, Imanishi T, Kawano S, Yano Y, Saegusa J
- Organizer
  American College of Rheumatology 85th Annual Scientific Meeting
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21K08437
[Presentation] Combination therapy of rapamycin and a glutamine antagonist facilitates the expansion of myeloid-derived suppressor cells and ameliorates arthritis in SKG mice.2018
- Author(s)
  Ueda Y, Saegusa J, Okano T, Sendo S, Yamada H, Ichise Y, Naka I, Takahashi S, Akashi K, Onishi A, Morinobu A
- Organizer
  The 19th Annual European Congress of Rheumatology - EULAR
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K08387
[Presentation] Tofacitinib facilitates the expansion of myeloid-derived suppressor cells and ameliorates interstitial lung disease in SKG mice.2018
- Author(s)
  Sendo S, Saegusa J, Ichise Y, Yamada H, Naka I, Ueda Y, Okano T, Morinobu A
- Organizer
  American College of Rheumatology 82nd Annual Scientific Meeting
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K08387
[Presentation] Combined inhibition of mechanistic target of rapamycin and glutamine metabolism inhibits CD4 T cell proliferation and Th17 differentiation, facilitates the expansion of myeloid-derived suppressor cells, and synergistically ameliorates arthritis in SKG mice.2018
- Author(s)
  Ueda Y, Saegusa J, Okano T, Sendo S, Yamada H, Akashi K, Onishi A, Morinobu A
- Organizer
  American College of Rheumatology 82nd Annual Scientific Meeting
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K08387
[Presentation] CD11b+Gr1dimTolerogenic Dendritic Cell-Like Cells are Expanded in Interstitial Lung Disease of SKG Mice2017
- Author(s)
  Sendo Sho, Saegusa Jun, Ichise Yoshihide, Yamada Hirotaka, Naka Ikuko, Okano Takaichi, Takahashi Soshi, Ueda Yo, Akashi Kengo, Onishi Akira, Kogata Yoshinori, Morinobu Akio
- Organizer
  第61回日本リウマチ学会総会・学術集会
- Data Source
  KAKENHI-PROJECT-15K09525
[Presentation] Glutamine metabolism plays a key role in the cell growth of fibroblast-like synoviocytes in rheumatoid arthritis.2017
- Author(s)
  Takahashi S, Saegusa J, Yamada H, Ichise Y, Naka I, Okano T, Akashi K, Sendo S, Ueda Y, Onishi A, Morinobu A.
- Organizer
  The 18th Annual European Congress of Rheumatology - EULAR 2017
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K09525
[Presentation] CD11b+Gr1dim tolerogenic dendritic cell-like cells suppress the progression of interstitial lung disease in SKG mice.2017
- Author(s)
  Sendo S, Saegusa J, Yamada H, Ichise Y, Naka I, Ueda Y, Okano T, Takahashi S, Akashi K, Onishi A, Morinobu A.
- Organizer
  American College of Rheumatology 81 th Annual Scientific Meeting
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K09525
[Presentation] CD11b+Cr1dim tolerogenic dendritic cell-like cells are expanded in interstitial lung disease in SKG mice.2017
- Author(s)
  Sendo S, Saegusa J, Ichise Y, Yamada H, Naka I, Okano T, Takahashi S, Ueda Y, Akashi K, Onishi A, Morinobu A.
- Organizer
  The 18th Annual European Congress of Rheumatology - EULAR 2017
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K09525
[Presentation] 3-bromopyruvate ameliorate autoimmune arthritis by modulating Th17/Treg cell differentiation and suppressing dendritic cell activation)2017
- Author(s)
  Okano Takaichi, Saegusa Jun, Nishimura Keisuke, Ueda Yo, Sendo Sho, Takahashi Soshi, Nishida Miwa, Akashi Kengo, Onishi Akira, Morinobu Akio
- Organizer
  第61回日本リウマチ学会総会・学術集会
- Data Source
  KAKENHI-PROJECT-15K09525
[Presentation] Glutamine metabolism plays a crucial role in the pathogenesis of rheumatoid arthritis.2016
- Author(s)
  Takahashi S, Saegusa J, Naka I, Tsuda K, Okano T, Akashi K, Sendo S, Ueda Y, Onishi A, Kogata Y, Morinobu A.
- Organizer
  American College of Rheumatology 80th Annual Scientific Meeting
- Place of Presentation
  ワシントンDC、米国
- Year and Date
  2016-11-11
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K09525
[Presentation] Knockout of endothelin type B receptor signaling attenuates bleomycin-induced skin sclerosis in mice.2016
- Author(s)
  Akashi K, Saegusa J, Sendo S, Nishimura K, Tsuda K, Naka I, Okano T, Takahashi S, Nishida M, Ueda Y, Morinobu A.
- Organizer
  The 17th Annual European Congress of Rheumatology - EULAR 2016
- Place of Presentation
  イギリス　ロンドン
- Year and Date
  2016-06-11
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K09525
[Presentation] CD11b+Gr1dim cells, which are induced by GM-CSF produced by Th17 and group3 innate lymphoid cell, may facilitate the progression of pneumonitis in SKG mice.2016
- Author(s)
  Sendo S, Saegusa J, Okano T, Takahashi S, Morinobu A.
- Organizer
  American College of Rheumatology 80th Annual Scientific Meeting
- Place of Presentation
  ワシントンDC、米国
- Year and Date
  2016-11-11
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K09525
[Presentation] 3-bromopyruvate ameliorates autoimmune arthritis by exerting a dual effect on both Th17 and Treg cell differentiation and dendritic cell activation.2016
- Author(s)
  Okano T, Saegusa J, 　Nishimura K, Takahashi S, Sendo S, Ueda Y, Onishi A, Morinobu A.
- Organizer
  The 17th Annual European Congress of Rheumatology - EULAR 2016
- Place of Presentation
  イギリス　ロンドン
- Year and Date
  2016-06-09
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K09525
[Presentation] 3-bromopyruvate ameliorates autoimmune arthritis by exerting a dual effect on both Th17 and Treg cell differentiation and dendritic cell activation.2016
- Author(s)
  Okano T, Saegusa J, 　Nishimura K, Takahashi S, Sendo S, Ueda Y, Onishi A, Morinobu A.
- Organizer
  The 17th Annual European Congress of Rheumatology
- Place of Presentation
  ロンドン、英国
- Year and Date
  2016-06-08
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K09525
[Presentation] Dual effect of 3-bromopyruvate on both Th17 and Treg cell differentiation and dendritic cell activation ameliorates autoimmune arthritis in mice.2016
- Author(s)
  Okano T, Saegusa J, Nishimura K, Ueda Y, Sendo S, Takahashi S, Akashi K, Onishi A, Morinobu A.
- Organizer
  American College of Rheumatology 80th Annual Scientific Meeting
- Place of Presentation
  ワシントンDC、米国
- Year and Date
  2016-11-11
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K09525
[Presentation] Knockout of endothelin type B receptor signaling attenuates bleomycin-induced skin sclerosis in mice.2016
- Author(s)
  Akashi K, Saegusa J, Sendo S, Nishimura K, Tsuda K, Naka I, Okano T, Takahashi S, Nishida M, Ueda Y, Morinobu A.
- Organizer
  The 17th Annual European Congress of Rheumatology
- Place of Presentation
  ロンドン、英国
- Year and Date
  2016-06-08
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K09525
[Presentation] MicroRNA-124 inhibits progression of adjuvant-induced arthritis in rats.2015
- Author(s)
  Nakamachi Y, Ohnuma K, Uto K, Noguchi Y, Saegusa J, Kawano S.
- Organizer
  The 16th Annual European Congress of Rheumatology - EULAR　2015
- Place of Presentation
  イタリア　ローマ
- Year and Date
  2015-06-11
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K09525
[Presentation] Taurine as a biomarker for prediction of response to biologic therapy in rheumatoid arthritis.2015
- Author(s)
  Takahashi S, Saegusa J, Naka I, Tsuda K, Okano T, Akashi K, Nishida M, Nishimura K, Sendo S, Ueda Y, Onishi A, Kogata Y, Kageyama G, Morinobu A.
- Organizer
  American College of Rheumatology 79th Annual Scientific Meeting,
- Place of Presentation
  アメリカ　サンフランシスコ
- Year and Date
  2015-11-08
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K09525
[Presentation] Serum cytokine/chemokine profiles are useful for evaluating pathological conditions of rheumatoid arthritis and diagnosing anti-CCP antibody-negative patients.2013
- Author(s)
  Uga H, Okazawa T, Miyamoto Y, Hasegawa T, Saegusa J, Tsuji G, Sendo S, Morinobu A, Kumagai S, Kurata H
- Organizer
  American College of Rheumatology 77th Annual Scientific Meeting
- Place of Presentation
  San Diego, CA
- Data Source
  KAKENHI-PROJECT-24591445
[Presentation] Clinical Features of 127 patients with Behcet’s disease in Japan.2013
- Author(s)
  Nishimura K, Saegusa J, Sendo S, Kogata Y, Kageyama G, Kawano S, Kumagai S, Morinobu A
- Organizer
  American College of Rheumatology 77th Annual Scientific Meeting
- Place of Presentation
  San Diego, USA
- Data Source
  KAKENHI-PROJECT-24591445
[Presentation] Immediate Early Response Gene X-1 is Over-expressed and Regulates Apoptosis and Cytokine Production in Rheumatoid Arthritis Synovial Fibroblasts2012
- Author(s)
  Akio Morinobu, Masaaki Fujita, Shino Tanaka, Jun Saegusa and Shunichi Kumagai
- Organizer
  第76回アメリカリウマチ学会
- Place of Presentation
  Walter E Washington Convention Center(米国・ワシントン）
- Data Source
  KAKENHI-PROJECT-24591445
[Presentation] Serum Metabolomics As a Novel Diagnostic Approach for Systemic Lupus Erythematosus2012
- Author(s)
  Saegusa J, Irino Y, Yoshida M, Tanaka S, Kogata Y, Kageyama G, Kawano S, Tsuji G, Kumagai S, Morinobu A
- Organizer
  American College of Rheumatology 76th Annual ScientificMeeting(アメリカリウマチ学会)
- Place of Presentation
  Washington DC
- Data Source
  KAKENHI-PROJECT-22790929
[Presentation] Early Growth Response-1 (EGR-1) Controls Synoviocyte Apoptosis, and Its Expression Is Regulated by the Direct Binding of Fibroblast Growth Factor-1 (FGF1) or Insulin-Like Growth Factor-1 (IGF1) to Integrin αvβ32012
- Author(s)
  Tanaka S, Saegusa J, Kawano S, Takada Y, Kumagai S, Morinobu A
- Organizer
  American College of Rheumatology 76thAnnual Scientific Meeting(アメリカリウマチ学会)
- Place of Presentation
  Washington DC
- Data Source
  KAKENHI-PROJECT-22790929
[Presentation] 遺伝子多型に基づくサラゾスルファピリジン(SASP)の有効性の検討　関節リウマチの個別化医療2012
- Author(s)
  萩原　慶明、辻　剛、千藤　荘、岡田　信彦、一瀬　良英、三枝　淳、熊谷　俊一
- Organizer
  第59回日本臨床検査医学会　学術集会
- Place of Presentation
  国立京都国際会館（京都）
- Data Source
  KAKENHI-PROJECT-24591445
[Presentation] Th17細胞はSKG関節炎モデルマウスの病態形成に関与する2012
- Author(s)
  宮本佳昭、田中聡、池田昌郁、宇賀均、三枝淳、森信暁雄、熊谷俊一、倉田寛一
- Organizer
  第22回日本サイトメトリー学会学術集会
- Place of Presentation
  千里ライフサイエンスセンター（大阪）
- Data Source
  KAKENHI-PROJECT-24591445
[Presentation] Th17細胞はSKG関節炎モデルマウスの病態形成に関与する2012
- Author(s)
  宮本　佳昭、田中　聡、池田　雅郁、宇賀　均、三枝　淳、森信　暁雄、熊谷　俊一、倉田　寛一
- Organizer
  第40回日本臨床免疫学会総会
- Place of Presentation
  京王プラザホテル（東京）
- Data Source
  KAKENHI-PROJECT-24591445
[Presentation] 4つの表面マーカーを用いた新規分類法によるRAの病原性　CD4陽性T細胞の探求2012
- Author(s)
  松木　郁親、三枝　淳、熊谷　俊一、森信　暁雄
- Organizer
  第33回日本炎症・再生医学会
- Place of Presentation
  ホテル日航福岡（福岡）
- Data Source
  KAKENHI-PROJECT-24591445
[Presentation] Immediate Early Response Gene X-1 is Over-expressed and Regulates Apoptosis and Cytokine Production in Rheumatoid Arthritis Synovial Fibroblasts2012
- Author(s)
  Akio Morinobu, Jun Saegusa, Shino Tanaka, Shunichi Kumagai
- Organizer
  第41回日本免疫学会学術集会
- Place of Presentation
  神戸国際会議場（神戸）
- Data Source
  KAKENHI-PROJECT-24591445
[Presentation] Regulatory and Pro-Inflammatory Properties of CD4+ T-Cell Subsets Defined by CD45RA, CCR7, CD27, and CD28 in Patients with Rheumatoid Arthritis2012
- Author(s)
  Fumichika Matsuki, Jun Saegusa, Yoshiaki Miyamoto, Keisuke Nishimura, Shino Tanaka, Shunichi Kumagai, Akio Morinobu
- Organizer
  第41回日本免疫学会学術集会
- Place of Presentation
  神戸国際会議場（神戸）
- Data Source
  KAKENHI-PROJECT-24591445
[Presentation] Regulatory and pro-inflammatory properties of CD4+ T-cell subsets defined by CD45RA, CCR7, CD27, and CD28 in patients with rheumatoid arthritis.2012
- Author(s)
  Matsuki F, Saegusa J, Miyamoto Y, Misaki K, Kumagai S, Morinobu A
- Organizer
  The 12th meeting of the Asian Society of Clinical Pathology and Laboratory Medicine (アジア臨床病理・臨床検査医学会)
- Place of Presentation
  Kyoto
- Data Source
  KAKENHI-PROJECT-22790929
[Presentation] 関節リウマチの病態に関与するCD4陽性T細胞サブセットの同定2012
- Author(s)
  松木　郁親、三枝　淳、熊谷　俊一、森信　暁雄
- Organizer
  第40回日本臨床免疫学会総会
- Place of Presentation
  京王プラザホテル（東京）
- Data Source
  KAKENHI-PROJECT-24591445
[Presentation] 自己抗原SS-A/Ro52はBcl-2の発言を低下させることにより細胞のアポトーシスを促進する2012
- Author(s)
  Jauharoh Siti Nur Aisyah、三枝　淳、笠木　伸平、杉山　大典、栗本　千代、中町　祐司、信原　由実子、杉本　健、森信　暁雄、熊谷　俊一、河野　誠司
- Organizer
  第56回日本リウマチ学会総会・学術集会・第21回国際リウマチシンポジウムプログラム
- Place of Presentation
  グランドプリンスホテル新高輪（東京）
- Data Source
  KAKENHI-PROJECT-24591445
[Presentation] 生物学的製剤（TNF阻害薬）無効ｱﾀﾞﾘﾑﾏﾌﾞ(ADA)投与RA患者における抗ｱﾀﾞﾘﾑﾏﾌﾞ抗体(AAA)産生と血中ADA濃度および効果の関係（追加報告）2012
- Author(s)
  辻　剛、河野　誠司、森信　暁雄、三枝　淳、杉山　大典、八木田　正人、旗智　さおり、波内　俊三、信原　由実子、中澤　隆、中村　知子、岡田　信彦、千藤　荘、熊谷　俊一
- Organizer
  第56回日本リウマチ学会総会・学術集会・第21回国際リウマチシンポジウムプログラム
- Place of Presentation
  グランドプリンスホテル新高輪（東京）
- Data Source
  KAKENHI-PROJECT-24591445
[Presentation] Early Growth Response-1(EGR-1)Controls Synoviocyte Apoptosis, and Its Expression is Regulated by the Direct Binding of Fibroblast Growth Factor-1(FGF1)or Insulin-Like Growth Factor-1(IGF1) to Integrin αvβ3.2012
- Author(s)
  Shino Tanaka, Jun Saegusa, Seiji Kawano, Yoshikazu Takada, Shunichi Kumagai and Akio Morinobu
- Organizer
  第76回アメリカリウマチ学会
- Place of Presentation
  Walter E Washington Convention Center(米国・ワシントン）
- Data Source
  KAKENHI-PROJECT-24591445
[Presentation] 関節リウマチの治療　DMARDs・NSAIDs(3)遺伝子多型に基づくサラゾスルファピリジン(SASP)の有効的使用法　関節リウマチの個別化医療2012
- Author(s)
  熊谷　俊一、萩原　慶明、千藤　荘、岡田　信彦、杉山　大典、三枝　淳、辻　剛
- Organizer
  第56回日本リウマチ学会総会・学術集会・第21回国際リウマチシンポジウムプログラム
- Place of Presentation
  グランドプリンスホテル新高輪（東京）
- Data Source
  KAKENHI-PROJECT-24591445
[Presentation] 4つの表面マーカーを用いた新規分類法によるRAの病原性CD4陽性T細胞の探求2012
- Author(s)
  松木　郁親、三枝　淳、宮本　佳昭、三崎　健太、河野　誠司、熊谷　俊一、森信　暁雄
- Organizer
  第56回日本リウマチ学会総会・学術集会・第21回国際リウマチシンポジウムプログラム
- Place of Presentation
  グランドプリンスホテル新高輪（東京）
- Data Source
  KAKENHI-PROJECT-24591445
[Presentation] Serum Metabolomics As a Novel Diagnostic Approach for Systemic Lupus Erythematosus.2012
- Author(s)
  Jun Saegusa, Yasuhiro Irino, Masaru Yoshida, Shino Tanaka, Yoshinori Kogata, Goichi Kageyama, Seiji Kawano, Goh Tsuji, Shunichi Kumagai and Akio Morinobu
- Organizer
  第76回アメリカリウマチ学会
- Place of Presentation
  Walter E Washington Convention Center(米国・ワシントン）
- Data Source
  KAKENHI-PROJECT-24591445
[Presentation] Induces CD8a Positive Tolerogenic Dendritic Cells, Regulatory T Cells in SKG Mice, and Ameliorates the Severe Arthritis2011
- Author(s)
  Misaki K, Morinobu A, Saegusa J, Kasagi S, Fujita M, Miyamoto Y, Matsuki F, Kumagai S. Trichostatin A
- Organizer
  American College of Rheumatology 75th Annual ScientificMeeting(アメリカリウマチ学会)
- Place of Presentation
  Chicago
- Data Source
  KAKENHI-PROJECT-22790929
[Presentation] 若手研究者が語るリウマチ性疾患の病態とシグナル伝達　インテグリンと増殖因子受容体の"two receptor model"2011
- Author(s)
  三枝　淳
- Organizer
  第55回日本リウマチ学会総会・学術集会・国際リウマチシンポジウム
- Place of Presentation
  神戸ポートピアホテル（神戸）
- Data Source
  KAKENHI-PROJECT-22790929
[Presentation] The Sjogren's Syndrome-Related Autoantigen Ro52 Is a Pro-Apoptotic Molecule Upon Oxidative Stress2011
- Author(s)
  Jauharoh SN, Kawano S, Saegusa J, Sugimoto T, Sugiyama D, Tokuno O, Kurimoto C, Nobuhara Y, Nakamachi Y, Ardianto B, Kumagai S
- Organizer
  American College of Rheumatology 75th Annual ScientificMeeting(アメリカリウマチ学会)
- Place of Presentation
  Chicago
- Data Source
  KAKENHI-PROJECT-22790929
[Presentation] インテグリンと増殖因子受容体の"two-receptor" model. 日本リウマチ学会カレントシンポジウム4 若手研究者が語るリウマチ性疾患の病態とシグナル伝達2011
- Author(s)
  三枝淳
- Organizer
  第55回日本リウマチ学会総会学術集会
- Place of Presentation
  神戸
- Data Source
  KAKENHI-PROJECT-22790929
[Presentation] An integrin-binding-defective FGFR50E mutant promotes synoviocyte apoptosis by activating caspase-9 through modulation of Bcl-2 and Bim expression2010
- Author(s)
  Saegusa J
- Organizer
  International Workshop, The 54^<th> Annual general Assembly and Scientific Meeting of Japan College of Rheumatology
- Place of Presentation
  神戸ポートピアホテル(兵庫県)(招待講演)
- Year and Date
  2010-04-22
- Data Source
  KAKENHI-PROJECT-22790929
[Presentation] Galectin-3 is critical for the development of the allergic inflammatory response in a mouse model of atopic dermatitis2010
- Author(s)
  Saegusa J, Morinobu A, Kawano S, Kumagai S, Hsu DK, Chen HY, Yu L, Liu FT
- Organizer
  International Congress of Immunology(国際免疫学会)
- Place of Presentation
  Kobe
- Data Source
  KAKENHI-PROJECT-22790929
[Presentation] THE PROINFLAMMATORY ACTION OF PHOSPHOLIPASE A2 GROUP IIA IS MEDIATED THROUGH INTERACTION WITH INTEGRINS(ALPHA)V(BETA)3 AND (ALPHA)4(BETA)12010
- Author(s)
  Saegusa J
- Organizer
  Annual European Congress of Rheumatology EULAR 2010
- Place of Presentation
  Rome, (Italy)
- Year and Date
  2010-06-18
- Data Source
  KAKENHI-PROJECT-22790929
[Presentation] Histone Deacetylase Inhibitor (HDAi) Ameliorates Chronic Arthritis in SKG Mice by Altering Conventional Dendritic Cells (cDCs) Phenotype into Tolerogenic DCs2010
- Author(s)
  Misaki K, Morinobu A, Saegusa J, Miyamoto Y, Kasagi S, Kumagai S
- Organizer
  American College of Rheumatology 74th Annual ScientificMeeting(アメリカリウマチ学会)
- Place of Presentation
  Atlanta
- Data Source
  KAKENHI-PROJECT-22790929
[Presentation] インテグリン非結合FGF1はBcl-2関連蛋白を制御して滑膜細胞のアポトーシスを誘導する2010
- Author(s)
  三枝淳
- Organizer
  第54回日本リウマチ学会総会・学術集会
- Place of Presentation
  神戸ポートピアホテル(兵庫県)
- Year and Date
  2010-04-24
- Data Source
  KAKENHI-PROJECT-22790929
[Presentation] Saegusa J, Fujita M, Morinobu A, Misaki K, Kawano S, Kumagai S2010
- Author(s)
  Saegusa J, Fujita M, Morinobu A, Misaki K, Kawano S, Kumagai S
- Organizer
  Annual general Assembly and Scientific Meeting of Japan College of Rheumatology(日本リウマチ学会総会・学術集会国際ワークショップ)
- Place of Presentation
  Kobe
- Data Source
  KAKENHI-PROJECT-22790929
[Presentation] THE PROINFLAMMATORY ACTION OF PHOSPHOLIPASE A2 GROUP IIA IS MEDIATED THROUGH INTERACTION WITH INTEGRINS (ALPHA)v(BETA)3 AND (ALPHA)4(BETA)12010
- Author(s)
  Saegusa J, Morinobu A, Kawano S, Takada Y, Kumagai S
- Organizer
  Annual European Congress of Rheumatology, EULAR(欧州リウマチ学会)
- Place of Presentation
  Rome
- Data Source
  KAKENHI-PROJECT-22790929
[Presentation] Galectin-3 is critical for the development of the allergic inflammatory response in a mouse model of atopic dermatitis2010
- Author(s)
  Saegusa J
- Organizer
  14^<th> International Congress of Immunology
- Place of Presentation
  神戸ポートピアホテル(兵庫県)
- Year and Date
  2010-08-23
- Data Source
  KAKENHI-PROJECT-22790929
[Presentation] HISTONE DEACETYLASE INHIBITOR (HDAI) AMELIORATES CHRONIC ARTHRITIS IN SKG MICE BY ALTERING CONVENTIONAL DENDRITIC CELLS (CDCS) PHENOTYPE INTO TOLEROGENIC DCS.2010
- Author(s)
  Misaki K, Morinobu A, Saegusa J, Miyamoto Y, Kasagi S, Kumagai S
- Organizer
  Annual European Congress of Rheumatology, EULAR(欧州リウマチ学会)
- Place of Presentation
  Rome
- Data Source
  KAKENHI-PROJECT-22790929
[Presentation] インテグリンはホスホリパーゼA2 group IIA(sPLA2-ILA)のレセプターとして働き炎症性シグナルを伝達する2009
- Author(s)
  三枝淳
- Organizer
  第53回日本リウマチ学会総会・学術集会
- Place of Presentation
  グランドプリンスホテル新高輪(東京都)
- Year and Date
  2009-04-25
- Data Source
  KAKENHI-PROJECT-20890126
[Presentation] インテグリンはホスホリパーゼA2 group IIA(sPLA2-IIA)のレセプターとして働き炎症性シグナルを伝達する2009
- Author(s)
  三枝淳
- Organizer
  第53回日本リウマチ学会総会・学術集会
- Place of Presentation
  東京
- Year and Date
  2009-04-25
- Data Source
  KAKENHI-PROJECT-20890126
[Presentation] An integrin binding- defective FGFR50E mutant promotes synoviocyte apoptosis by activating caspase-9 through modulation of Bcl-2 and Bim expression.2009
- Author(s)
  J Saegusa
- Organizer
  第39回日本免疫学会総会・学術集会
- Place of Presentation
  大阪
- Year and Date
  2009-12-04
- Data Source
  KAKENHI-PROJECT-20890126
[Presentation] エタネルセプト(Eta. )投与下にリステリア髄膜脳炎を発症した関節リウマチ(RA)の一例2009
- Author(s)
  西田美和、林宏樹、辻剛、三枝淳、杉本健、河野誠司、森信暁雄、熊谷俊一
- Organizer
  第53回日本リウマチ学会
- Place of Presentation
  東京
- Year and Date
  2009-04-23
- Data Source
  KAKENHI-PROJECT-19390155
[Presentation] An integrin binding-defective FGF^<R50E> mutant promotes synoviocyte apoptosis by activating caspase-9 through modulation of Bcl-2 and Bim expression2009
- Author(s)
  三枝淳
- Organizer
  第39回日本免疫学会総会・学術集会
- Place of Presentation
  大阪国際会議場(大阪府)
- Year and Date
  2009-12-04
- Data Source
  KAKENHI-PROJECT-20890126
[Presentation] Secretory Phospholipase A2 Group IIA Binds to Integrin avss3 and Induces Proinflammatory Signaling2009
- Author(s)
  三枝淳
- Organizer
  American College of Rheumatology, Annual Scientific Meeting
- Place of Presentation
  Philadelphia, USA
- Year and Date
  2009-10-20
- Data Source
  KAKENHI-PROJECT-20890126
[Presentation] 急性期蛋白ホスホリパーゼA2 group IIAはインテグリンと結合して細胞内に炎症性シグナルを伝える2009
- Author(s)
  三枝淳
- Organizer
  第56回日本臨床検査医学会総会・学術集会
- Place of Presentation
  札幌コンベンションセンター(北海道)
- Year and Date
  2009-08-27
- Data Source
  KAKENHI-PROJECT-20890126
[Presentation] Prevalence of Anti-Cyclic Citrullinated Peptide Antibody and Its Association with Smoking in General Population : a Cross Sectional Study.2009
- Author(s)
  Kumagai S, Hayashi N, Kawano S, Sugiyama D, Nishimura K, Kasagi S, Saegusa J, Morinobou A
- Organizer
  第75回米国リウマチ学会
- Place of Presentation
  サンフランシスコ(アメリカ合衆国)
- Data Source
  KAKENHI-PROJECT-19390155
[Presentation] エタネルセプト(Eta.)投与下にリステリア髄膜脳炎を発症した関節リウマチ(RA)の1例2009
- Author(s)
  西田美和、林宏樹、辻剛、三枝淳、杉本健、河野誠司、森信暁雄、熊谷俊一
- Organizer
  第53回日本リウマチ学会総会・学術集会
- Place of Presentation
  グランドプリンスホテル新高輪(東京都)
- Year and Date
  2009-04-26
- Data Source
  KAKENHI-PROJECT-19390155
[Presentation] Secretory Phospholipase A2 Group IIA Binds to Integrin avβ3 and Induces Proinflammatory Signaling.2009
- Author(s)
  J Saegusa
- Organizer
  第75回米国リウマチ学会
- Place of Presentation
  フィラデルフィア
- Year and Date
  2009-10-20
- Data Source
  KAKENHI-PROJECT-20890126
[Presentation] Secretory Phospholipase A2 Group Binds to Integrin v3 and Induces Proinflammatory Signaling.2009
- Author(s)
  Saegusa J, Fujita M, Tanaka S, Morinobu A, Kawano S, Takada Y, Kumagai S
- Organizer
  第75回米国リウマチ学会
- Place of Presentation
  サンフランシスコ(アメリカ合衆国)
- Data Source
  KAKENHI-PROJECT-19390155
[Presentation] Secretory Phospholipase A2 Group Binds to Integrin v3 and Induces Proinflammatory Signaling.2009
- Author(s)
  Saegusa J, Fujita M, Tanaka S, Morinobu A, Kawano S, Takada Y, Kumagai S.
- Organizer
  第75回米国リウマチ学会
- Place of Presentation
  フィラデルフィア
- Year and Date
  2009-10-20
- Data Source
  KAKENHI-PROJECT-19390155
[Presentation] Prevalence of Anti-Cyclic Citrullinated Peptide Antibody and Its Association with Smoking in General Population : a Cross Sectional Study.2009
- Author(s)
  Kumagai S, Hayashi N, Kawano S, Sugiyama D, Nishimura K, Kasagi S, Saegusa J, Morinobu A.
- Organizer
  第75回米国リウマチ学会
- Place of Presentation
  フィラデルフィア
- Year and Date
  2009-10-20
- Data Source
  KAKENHI-PROJECT-19390155
[Presentation] 急性期蛋白ホスホリパーゼA2 group IIAはインテグリンと結合して細胞内に炎症性シグナルを伝える2009
- Author(s)
  三枝淳
- Organizer
  第56回日本臨床検査医学会学術集会
- Place of Presentation
  札幌
- Year and Date
  2009-08-27
- Data Source
  KAKENHI-PROJECT-20890126
[Presentation] ガレクチン-3は皮膚アレルギー性炎症の進行に重要な役割を果たしている2008
- Author(s)
  三枝淳
- Organizer
  第38回日本免疫学会総会・学術集会
- Place of Presentation
  京都
- Data Source
  KAKENHI-PROJECT-20890126
[Presentation] Galectin-3 promotes activation of AKT and protects keratinocytes from apoptosis2008
- Author(s)
  J Saegusa
- Organizer
  International Investigative Dermatology
- Place of Presentation
  京都
- Data Source
  KAKENHI-PROJECT-20890126
[Presentation] ガレクチン-3は皮膚アレルギー性炎症の進行に重要な役割を果たしている2008
- Author(s)
  三枝淳
- Organizer
  日本免疫学会総会・学術集会
- Place of Presentation
  京都
- Data Source
  KAKENHI-PROJECT-20890126
[Presentation] Galectin-3 promotes activation of AKT and protects keratinocytes from apoptosis2008
- Author(s)
  Saegusa J
- Organizer
  International Investigative Dermatology
- Place of Presentation
  Kyoto
- Data Source
  KAKENHI-PROJECT-20890126
[Presentation] シェーグレン症候群患者の唾液メタボロミクス
- Author(s)
  蔭山豪一, 三枝淳, 田中姿乃, 大西輝, 古形芳則, 森信暁雄
- Organizer
  第23回日本シェーグレン症候群学会学術集会
- Place of Presentation
  長崎
- Year and Date
  2014-09-12 – 2014-09-13
- Data Source
  KAKENHI-PROJECT-24591445
[Presentation] 血清メタボロミクスによる全身性エリテマトーデスの新規バイオマーカーの探索
- Author(s)
  三枝淳, 河野誠司, 辻剛, 熊谷俊一, 森信暁雄
- Organizer
  第61回日本臨床検査医学会学術集会
- Place of Presentation
  福岡
- Year and Date
  2014-11-22 – 2014-11-25
- Data Source
  KAKENHI-PROJECT-24591445
[Presentation] 自己免疫疾患のメタボローム解析の未来～新規バイオマーカーの同定と病態解明を目指して～
- Author(s)
  三枝淳
- Organizer
  日本臨床検査医学会第57回近畿支部総会
- Place of Presentation
  神戸
- Year and Date
  2014-09-20 – 2014-09-21
- Invited
- Data Source
  KAKENHI-PROJECT-24591445

1. KAWANO Seiji (20351512)

# of Collaborated Projects: 9 results

# of Collaborated Products: 29 results
2. MORINOBU Akio (10294216)

# of Collaborated Projects: 6 results

# of Collaborated Products: 75 results
3. NAKAMACHI Yuji (80379429)

# of Collaborated Projects: 5 results

# of Collaborated Products: 2 results
4. KASAGI SHINPEI (80457051)

# of Collaborated Projects: 3 results

# of Collaborated Products: 0 results
5. KUMAGAI Shunichi (00153346)

# of Collaborated Projects: 1 results

# of Collaborated Products: 8 results
6. NISHIMURA Kunihiro (70397834)

# of Collaborated Projects: 1 results

# of Collaborated Products: 3 results
7. 中澤隆 (40397831)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
8. 蔭山豪一 (80631621)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
9. 籏智さおり (70414117)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
10. 西村啓佑 (20771497)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
11. 脇大輔 (00914243)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
12. 大西輝 (60634269)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
13. 青井貴之 (00546997)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
14. TAKADA Yoshikazu

# of Collaborated Projects: 1 results

# of Collaborated Products: 4 results
15. Noguchi Yoriko

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
16. Onuma Kenichiro

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
17. 林宏樹

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Saegusa Jun 三枝 淳

SAEGUSA Jun 三枝 淳

Research Projects

Research Products

Co-Researchers

Analysis of autoreactive T cells in rheumatoid arthritis using iPS cell technologyPrincipal Investigator

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Development of a novel diagnostic and therapeutic strategy for systemic autoimmune diseases focusing on extracellular vesiclesPrincipal Investigator

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The fluctuation in subjective well-being of patients with early rheumatoid arthritis

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Inetraction of non-coding RNA specific for rheumatoid arthritis

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Development of novel therapeutic strategies targeting cellular metabolism in autoimmune diseasesPrincipal Investigator

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Role of exosomes in the pathology of rheumatoid arthritis

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Study of target molecules of rheumatoid arthritis-associated miRNA.

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A metabolic approach for discovering therapeutic target in rheumatoid arthritis synovial fibroblastPrincipal Investigator

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Development of the novel therapy for rheumatoid arthritis by micro RNA-containing exosomes

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Study of the role of miRNA in the regulation of osteoclast differentiation in rheunmatoid arthritis joints

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Metabolomics for biomarker discovery in systemic lupus erythematosusPrincipal Investigator

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Development of a novel therapeutic method for rheumatoid arthritis by targeting growth factor signalingPrincipal Investigator

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Analysis of signaling pathways induced by the binding of IL-1・to integrinsPrincipal Investigator

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Saegusa Jun 三枝淳

SAEGUSA Jun 三枝淳