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ASANO NAOKI  浅野 直喜

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ASANO Naoki  浅野 直喜

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Researcher Number 20526454
Other IDs
Affiliation (Current) 2025: 地方独立行政法人宮城県立病院機構宮城県立がんセンター(研究所), がん幹細胞研究部, 部長
Affiliation (based on the past Project Information) *help 2025: 地方独立行政法人宮城県立病院機構宮城県立がんセンター(研究所), がん幹細胞研究部, 部長
2023 – 2024: 東北大学, 医学系研究科, 講師
2018 – 2021: 東北大学, 医学系研究科, 講師
2011 – 2017: 東北大学, 大学病院, 助教
2012: 東北大学, 病院, 助教
2010: Tohoku University, 病院, 助教
2009: Tohoku University, 病院, 医員
Review Section/Research Field
Principal Investigator
Gastroenterology / Basic Section 53010:Gastroenterology-related
Except Principal Investigator
Basic Section 53010:Gastroenterology-related
Keywords
Principal Investigator
NOD1 / 老化 / 腸上皮化生 / 自然免疫 / 胃粘膜萎縮 / 上部消化管学(食道、胃、十二指腸) / gastric cancer / organoid / aging / 幹細胞 … More / 胃 / 発癌 / オルガノイド / 上部消化管 / Sox2 / Helicobacter pylori / Cdx2 / NFkB / NFκB / TGF-β / ヘリコバクター・ピロリ … More
Except Principal Investigator
がん幹細胞 / 膵癌 / FAXC / 幹細胞老化 / バレット食道癌 Less
  • Research Projects

    (8 results)
  • Research Products

    (15 results)
  • Co-Researchers

    (3 People)
  •  造腫瘍能の高いがん細胞を標的とした新たな膵癌治療へ向けての基礎的検討

    • Principal Investigator
      佐藤 賢一
    • Project Period (FY)
      2025 – 2027
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 53010:Gastroenterology-related
    • Research Institution
      Tohoku Medical and Pharmaceutical University
  •  食道上皮幹細胞老化を介したバレット食道腺癌発生機序の解明

    • Principal Investigator
      小池 智幸
    • Project Period (FY)
      2024 – 2026
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 53010:Gastroenterology-related
    • Research Institution
      Tohoku University
  •  免疫関連分子による上皮幹細胞の維持・分化を介した胃老化・発癌制御機序の解明Principal Investigator

    • Principal Investigator
      浅野 直喜
    • Project Period (FY)
      2023 – 2025
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 53010:Gastroenterology-related
    • Research Institution
      Tohoku University
  •  The predominance of senescence-evading aged gastric epithelial cells may contribute to aging-related gastric carcinogenesisPrincipal Investigator

    • Principal Investigator
      ASANO Naoki
    • Project Period (FY)
      2019 – 2021
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 53010:Gastroenterology-related
    • Research Institution
      Tohoku University
  •  Innate immunity-mediated regulation of aging and carcinogenesis in the stomachPrincipal Investigator

    • Principal Investigator
      ASANO NAOKI
    • Project Period (FY)
      2016 – 2018
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Gastroenterology
    • Research Institution
      Tohoku University
  •  Innate immunity-mediated regulation on the induction of precancerous lesions in the stomach.Principal Investigator

    • Principal Investigator
      Asano Naoki
    • Project Period (FY)
      2013 – 2015
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Gastroenterology
    • Research Institution
      Tohoku University
  •  Cross talk between the innate immune response and trans- differentiation/carcinogenesis in the gastric epitheliumPrincipal Investigator

    • Principal Investigator
      ASANO Naoki
    • Project Period (FY)
      2011 – 2012
    • Research Category
      Grant-in-Aid for Young Scientists (B)
    • Research Field
      Gastroenterology
    • Research Institution
      Tohoku University
  •  Cooperation of TGF-β and Notch in the induction of intestinal metaplasia and cancer stem cells of the esophagus and stomachPrincipal Investigator

    • Principal Investigator
      ASANO Naoki
    • Project Period (FY)
      2009 – 2010
    • Research Category
      Grant-in-Aid for Young Scientists (B)
    • Research Field
      Gastroenterology
    • Research Institution
      Tohoku University

All 2022 2019 2016 2012 2011 2010 2009 Other

All Journal Article Presentation

  • [Journal Article] Cdx2 Expression and Intestinal Metaplasia Induced by H. pylori Infection of Gastric Cells Is Regulated by NOD1-Mediated Innate Immune Responses2016

    • Author(s)
      Asano N, Imatani A, Watanabe T, Fushiya J, Kondo Y, Jin X, Ara N, Uno K, Iijima K, Koike T, Strober W, Shimosegawa T
    • Journal Title

      Cancer Research

      Volume: 76 Issue: 5 Pages: 1135-1145

    • DOI

      10.1158/0008-5472.can-15-2272

    • Peer Reviewed / Acknowledgement Compliant / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-25460925
  • [Presentation] マウス胃オルガノイドを用いた加齢に伴う細胞老化回避による胃発癌機序の解明2022

    • Author(s)
      竹内章夫、浅野直喜、正宗淳
    • Organizer
      第108回日本消化器病学会総会 シンポジウム3:消化器疾患に対する分化・老化・再生研究の展開
    • Data Source
      KAKENHI-PROJECT-19K08411
  • [Presentation] THE EMERGENCE OF ANTI-SENESCENT PROPERTY IN AGED GASTRIC EPITHELIAL CELLS MAY CONTRIBUTE TO AGING-RELATED GASTRIC CARCINOGENESIS2022

    • Author(s)
      Akio Takeuchi, Naoki Asano, Akira Imatani, Masashi Saito, Xiaoyi Jin, Masahiro Saito, Takeshi Kanno, Waku Hatta, Kaname Uno, Tomoyuki Koike, Atsushi Masamune
    • Organizer
      DDW 2022 Research Forum: Pathogenesis of GI Metaplasia and Neoplasia
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-19K08411
  • [Presentation] NOD1 deficient gastric stem cells fail to differentiate to parietal cells and cause gastric mucosal atrophy2019

    • Author(s)
      浅野直喜、今谷晃、竹内章夫、高橋貴一、金笑奕、齊藤真弘、八田和久、淺沼清孝、宇野要、小池智幸、正宗淳
    • Organizer
      DDW2019
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-16K09278
  • [Presentation] NOD1 Expression in Gastric Epithelial Cells Is Down-Regulated By Helicobacter pylori Infection Through the Methylation of Its CpG Island By DNA Methyltransferases2016

    • Author(s)
      Mikami T, Asano N, Imatani A, Jin X, Kondo Y, Hatta W, Ara N, Asanuma K, Koike T, Shimosegawa T
    • Organizer
      Digestive Disease Week 2016
    • Place of Presentation
      San Diego, CA, U.S.A.
    • Year and Date
      2016-05-21
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-25460925
  • [Presentation] Helicobacter pylori感染においてNOD1はCdx2の制御を介して腸上皮化生進展を抑制する2012

    • Author(s)
      浅野直喜、今谷晃、下瀬川徹
    • Organizer
      第98回日本消化器病学会総会
    • Place of Presentation
      東京
    • Year and Date
      2012-04-19
    • Data Source
      KAKENHI-PROJECT-23790766
  • [Presentation] NOD1, the innate immunity related molecule, suppresses Helicobacter pylori induced gastric intestinal metaplasia through regulation of homeobox gene Cdx22011

    • Author(s)
      浅野直喜、今谷晃、近藤穣、千葉隆士、伏谷淳、阿部靖彦、飯島克則、小池智幸、下瀬川徹
    • Organizer
      DDW 2011
    • Place of Presentation
      サンディエゴ・アメリカ
    • Year and Date
      2011-05-09
    • Data Source
      KAKENHI-PROJECT-23790766
  • [Presentation] NOD1 suppresses H.pylori induced IM through Cdx22011

    • Author(s)
      浅野 直喜
    • Organizer
      Digestive Disease Week 2011
    • Place of Presentation
      シカゴ、アメリカ合衆国
    • Data Source
      KAKENHI-PROJECT-23790766
  • [Presentation] 低分化型胃癌におけるRBP-Jκを介したNotch1シグナルによる増殖、造腫瘍能、CD133発現の制御機構2010

    • Author(s)
      浅野直喜
    • Organizer
      第69回日本癌学会総会
    • Place of Presentation
      大阪国際会議場
    • Year and Date
      2010-09-22
    • Data Source
      KAKENHI-PROJECT-21790647
  • [Presentation] RBP-J κ dependent Notch1 signaling regulates proliferation, tumorigenesis and CD133 in diffuse type gastric cancers2010

    • Author(s)
      浅野直喜、今谷晃、下瀬川徹
    • Organizer
      第69回日本癌学会総会
    • Place of Presentation
      大阪
    • Year and Date
      2010-09-22
    • Data Source
      KAKENHI-PROJECT-21790647
  • [Presentation] RBP-J κ dependent Notch1 signaling is required for the maintenance of stem-like cells in diffuse type gastric cancers2010

    • Author(s)
      浅野直喜、小西秀知、今谷晃、木村修、近藤穣、千葉隆士、宇野要、阿部靖彦、飯島克則、小池智幸、下瀬川徹
    • Organizer
      1st JSGE International Topic Conference
    • Place of Presentation
      鎌倉
    • Year and Date
      2010-09-25
    • Data Source
      KAKENHI-PROJECT-21790647
  • [Presentation] RBP-Jκ dependent Notch1 signaling is required for the maintenance of stem-like cells in diffuse type gastric cancers2010

    • Author(s)
      浅野直喜
    • Organizer
      The 1st JSGE International Topic Conference
    • Place of Presentation
      鎌倉パークホテル
    • Year and Date
      2010-09-25
    • Data Source
      KAKENHI-PROJECT-21790647
  • [Presentation] 低分化型胃癌におけるRBP-Jκを介したNotchシグナルによる幹細胞マーカーCD133発現機構2009

    • Author(s)
      浅野直喜、小西秀知、今谷晃、近藤穣、下瀬川徹
    • Organizer
      第17回浜名湖シンポジウム
    • Place of Presentation
      浜松
    • Year and Date
      2009-12-22
    • Data Source
      KAKENHI-PROJECT-21790647
  • [Presentation] ヒト低分化型胃癌におけるNotchシグナルを介した幹細胞マーカーCD133発現と発癌誘導機構2009

    • Author(s)
      小西秀知、浅野直喜、今谷晃、近藤穣、小池智幸、飯島克則、下瀬川徹
    • Organizer
      JDDW 2009
    • Place of Presentation
      京都
    • Year and Date
      2009-10-15
    • Data Source
      KAKENHI-PROJECT-21790647
  • [Presentation] Helicobacter pylori感染においてNOD1はCdx2の制御を介して腸上皮化生進展を抑制する

    • Author(s)
      浅野直喜
    • Organizer
      第98回日本消化器病学会総会
    • Place of Presentation
      東京
    • Data Source
      KAKENHI-PROJECT-23790766
  • 1.  小池 智幸 (00359514)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 2.  佐藤 賢一 (10282055)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 3.  STROBER Warren
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results

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