Shimada Mikio 島田幹男

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SHIMADA Mikio 島田幹男

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Researcher Number	20548557
Other IDs
Affiliation (Current)	2025: 東京科学大学, 総合研究院, 助教
Affiliation (based on the past Project Information) *help	2020 – 2024: 東京工業大学, 科学技術創成研究院, 助教 2010 – 2011: 京都大学, 放射線生物研究センター, 研究員
Review Section/Research Field	Principal Investigator Basic Section 63020:Radiation influence-related / Risk sciences of radiation/Chemicals Except Principal Investigator Medium-sized Section 34:Inorganic/coordination chemistry, analytical chemistry, and related fields / Broad Section E / Basic Section 63020:Radiation influence-related
Keywords	Principal Investigator 中心体 / 細胞分裂死 / がん治療 / 染色体不安定性 / 高LET放射線 / DNA切断 / 癌治療 / 重粒子線 / 染色体異常 / 発癌制御 / FANCD2 / 発癌 / DNA修復 … More Except Principal Investigator … More サイトメトリー / プラズマ分光分析 / 一細胞分析 / メタロミクス / 質量分析 / プラズマ / 微量元素分析 / 単一細胞 / 元素分析 / 発光分析 / 大気圧プラズマ / 単一細胞分析 / がん放射線治療 / タンパク質構造解析 / タンパク質間相互作用 / タンパク質リン酸化 / DNA損傷応答 / DNA修復 / 放射線 / DNA依存性プロテインキナーゼ(DNA-PK) Less

高LET放射線による細胞分裂死誘導メカニズムの解明とがん治療への応用Principal Investigator
- Principal Investigator
  
  島田幹男
- Project Period (FY)
  2022 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 63020:Radiation influence-related
- Research Institution
  Tokyo Institute of Technology
Development of ultra-sensitive high-throughput single cell elemental analysis system and creation of single cell metallomics
- Principal Investigator
  
  沖野晃俊
- Project Period (FY)
  2022 – 2026
- Research Category
  
  Grant-in-Aid for Scientific Research (S)
- Review Section
  
  Broad Section E
- Research Institution
  Institute of Science Tokyo
Development of a high-sensitive, high-throughput single-cell elemental analysis system directly connected to a flow cytometer
- Principal Investigator
  
  沖野晃俊
- Project Period (FY)
  2022
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Review Section
  
  Medium-sized Section 34:Inorganic/coordination chemistry, analytical chemistry, and related fields
- Research Institution
  Tokyo Institute of Technology
Biological Significance of DNA-PK in the Orchestration of Cellular Response to DNA Double-strand Breaks
- Principal Investigator
  
  Matsumoto Yoshihisa
- Project Period (FY)
  2020 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 63020:Radiation influence-related
- Research Institution
  Tokyo Institute of Technology
The role of DNA repair factor FNACD2 in centrosome duplication maintenancePrincipal Investigator
- Principal Investigator
  
  SHIMADA Mikio
- Project Period (FY)
  2010 – 2011
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Risk sciences of radiation/Chemicals
- Research Institution
  Kyoto University

All 2024 2023 2022 2021 2020 2011 2010

All Journal Article Presentation

[Journal Article] Implication of E3 ligase RAD18 in UV-induced mutagenesis in human induced pluripotent stem cells and neuronal progenitor cells.2023
- Author(s)
  Shimada M, Tokumiya T, Miyake T, Tsukada K, Kanzaki N, Yanagihara H, Kobayashi J, Matsumoto Y.
- Journal Title
  
  J Radiat Res.
  
  Volume: 64 Issue: 2 Pages: 343-351
- DOI
  10.1093/jrr/rrac099
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K12162, KAKENHI-PROJECT-22K12369, KAKENHI-PROJECT-21K19842, KAKENHI-PROJECT-20H04334, KAKENHI-PROJECT-22H04973
[Journal Article] APTX acts in DNA double-strand break repair in a manner distinct from XRCC42023
- Author(s)
  Imamura Rikiya、Saito Mizuki、Shimada Mikio、Kobayashi Junya、Ishiai Masamichi、Matsumoto Yoshihisa
- Journal Title
  
  Journal of Radiation Research
  
  Volume: Online ahead of print Issue: 3 Pages: 1-11
- DOI
  10.1093/jrr/rrad007
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-22K12369, KAKENHI-PROJECT-21K19842, KAKENHI-PROJECT-20H04334, KAKENHI-PROJECT-18K11642, KAKENHI-PROJECT-22H04973
[Journal Article] The role of DNA double-strand break repair through non-homologous end joining in the dose-rate effect in terms of clonogenic ability2022
- Author(s)
  Tsuchiya H, Shimada M, Tsukada K, Meng Q, Kobayashi J, Matsumoto Y.
- Journal Title
  
  Radiation Protection Dosimetry
  
  Volume: -
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20H04334
[Journal Article] THE ROLE OF DNA DOUBLE-STRAND BREAK REPAIR THROUGH NON-HOMOLOGOUS END JOINING IN THE DOSE-RATE EFFECT IN TERMS OF CLONOGENIC ABILITY2022
- Author(s)
  Tsuchiya Hisayo、Shimada Mikio、Tsukada Kaima、Meng Qingmei、Kobayashi Junya、Matsumoto Yoshihisa
- Journal Title
  
  Radiation Protection Dosimetry
  
  Volume: 198 Issue: 13-15 Pages: 990-997
- DOI
  10.1093/rpd/ncac030
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-22K12369
[Journal Article] α-glucosyl-rutin activates immediate early genes in human induced pluripotent stem cells.2021
- Author(s)
  Miyake T, Kuge M, Matsumoto Y, Shimada M.
- Journal Title
  
  Stem Cell Research
  
  Volume: 56 Pages: 102511-102511
- DOI
  10.1016/j.scr.2021.102511
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20H04334
[Journal Article] Functional analysis of XRCC4 mutations in reported microcephaly and growth defect patients in terms of radiosensitivity.2021
- Author(s)
  Asa ADDC, Wanotayan R, Sharma MK, Tsukada K, Shimada M, Matsumoto Y.
- Journal Title
  
  Journal of Radiation Research
  
  Volume: 62 Issue: 3 Pages: 380-389
- DOI
  10.1093/jrr/rrab016
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20H04334, KAKENHI-PROJECT-20J13601
[Journal Article] Diminished or inversed dose-rate effect on clonogenic ability in Ku-deficient rodent cells.2021
- Author(s)
  Tsuchiya H, Shimada M, Tsukada K, Meng Q, Kobayashi J, Matsumoto Y
- Journal Title
  
  Journal of Radiation Research
  
  Volume: 62 Issue: 2 Pages: 198-205
- DOI
  10.1093/jrr/rraa128
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K12162, KAKENHI-PROJECT-20H04334, KAKENHI-PROJECT-20J13601
[Journal Article] Phosphorylation of PNKP mediated by CDKs promotes end-processing of Okazaki fragments during DNA replication2021
- Author(s)
  Tsukada K, Imamura R, Saikawa K, Saito M, Kase N, Miyake T, Ishiai M, Matsumoto Y, Shimada M
- Journal Title
  
  bioRxiv
  
  Volume: -
- DOI
  10.1101/2021.07.29.452278
- Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20H04334, KAKENHI-PROJECT-20J13601
[Journal Article] DNA-dependent protein kinase catalytic subunit: The sensor for DNA double-strand breaks structurally and functionally related to Ataxia-Telangiectasia Mutated.2021
- Author(s)
  Matsumoto Y, Asa ADDC, Modak C, Shimada M.
- Journal Title
  
  Genes
  
  Volume: 12 Issue: 8 Pages: 1143-1143
- DOI
  10.3390/genes12081143
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20H04334
[Journal Article] The FHA domain of PNKP is essential for its recruitment to DNA damage sites and maintenance of genome stability2020
- Author(s)
  Tsukada K, Shimada M, Imamura R, Saikawa K, Ishiai M, Matsumoto Y.
- Journal Title
  
  Mutat Res.
  
  Volume: 822 Pages: 111727-111727
- DOI
  10.1016/j.mrfmmm.2020.111727
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K11642, KAKENHI-PROJECT-20H04334, KAKENHI-PROJECT-20J13601
[Journal Article] Linker region is required for efficient nuclear localization of polynucleotide kinase phosphatase.2020
- Author(s)
  Tsukada K, Matsumoto Y, Shimada M.
- Journal Title
  
  PLoS One
  
  Volume: 15 Issue: 9 Pages: e0239404-e0239404
- DOI
  10.1371/journal.pone.0239404
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20H04334, KAKENHI-PROJECT-20J13601
[Journal Article] Regulation of homologous recombination by RNF20-dependent H2Bubiquitination2011
- Author(s)
  Nakamura K, Kato A, Kobayashi J, Yanagihara H, Sakamoto S, Oliveira D, Shimada S, Tauchi H, Suzuki H, Tashiro S, Zou L, Komatsu K.
- Journal Title
  
  Mol Cell
  
  Volume: 41 Issue: 5 Pages: 515-528
- DOI
  10.1016/j.molcel.2011.02.002
- NAID
  130007000484
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21310035, KAKENHI-PROJECT-22710053, KAKENHI-PROJECT-22710054
[Journal Article] Regulation of homologous recombination by RNF20-dependent H2B ubiquitination.2011
- Author(s)
  K.Nakamura, A.Kato, J.Kobayashi, H.Yanagihara, S.Sakamoto, D.V.N.P.Oliveira, M.Shimada, H.Tauchi, H.Suzuki, S.Tashiro, L.Zou, K.Komatsu
- Journal Title
  
  Molcular Cell
  
  Volume: 41 Pages: 515-528
- NAID
  130007001514
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22710054
[Journal Article] Poteintial role of DNA repiar proteins in centrosome maintenance2011
- Author(s)
  Shimada M, Kato A, Kobayashi J.
- Journal Title
  
  Book 4/DNA
  
  Pages: 55-66
- DOI
  10.5772/21396
- ISBN
  9789533076973
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22710054
[Journal Article] Genistein, isoflavonoids in soybeans, prevents the formation of excess radiation-induced centrosomes via p21up-regulation2011
- Author(s)
  Shimada M, Kato A, Habu T, Komatsu K
- Journal Title
  
  Mutatation Research
  
  Volume: Volume 716 Issue: 1-2 Pages: 27-32
- DOI
  10.1016/j.mrfmmm.2011.07.017
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22710053, KAKENHI-PROJECT-22710054, KAKENHI-PROJECT-23241021, KAKENHI-PROJECT-23501267, KAKENHI-PROJECT-23651045
[Journal Article] Differential role of repair proteins, BRCA1/NBS1 and Ku70/DNA-PKc in radiation-induced centrosome over-duplication.2010
- Author(s)
  M.Shimada, J.Kobayashi, R.Hirayama, K.Komatsu
- Journal Title
  
  Cancer Science
  
  Volume: 101 Pages: 2531-2537
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22710054
[Journal Article] Differential role of repair proteins, BRCA1/NBS1 and Ku70/DNA-PKcs, in radiation-induced centrosome overduplication2010
- Author(s)
  Shimada M, Kobayashi J, Hirayama R, Komatsu K
- Journal Title
  
  Cancer Sci
  
  Volume: 101 Pages: 2531-2537
- NAID
  10027834303
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22710054
[Presentation] Whole genome sequencing analysis of human lymphocyte TK6 clones in culture2024
- Author(s)
  MILAI Enkhbaatar, Tsumbuukhuu Dulguun, 島田幹男, 松本義久
- Organizer
  Biological Effects & Application of Radiation 2024
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-22K12369
[Presentation] Simultaneous detection of DNA damage response and cell cycle status using Focicle reporter in human iPS cells and neural progenitor cells2024
- Author(s)
  島田幹男, 松本義久
- Organizer
  The 13th International Society of Radiation Neurobiology Conference
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-22K12369
[Presentation] 放射線の生体影響解明のための細胞生物学的研究2023
- Author(s)
  島田幹男
- Organizer
  ちゅうでん原子力安全技術研究所サイエンスフォーラム2023
- Invited
- Data Source
  KAKENHI-PROJECT-22K12369
[Presentation] Analysis of radiosensitization effect by the combination with PLK1 inhibition and heavy particle beam in p53 mutant cells2023
- Author(s)
  多田翔哉, 島田幹男, 塚田海馬, 今村力也
- Organizer
  日本放射線影響学会第66回大会
- Data Source
  KAKENHI-PROJECT-22K12369
[Presentation] 組織オルガノイドを用いた放射線誘発DNA損傷応答の解析2023
- Author(s)
  島田幹男
- Organizer
  第６０回アイソトープ・放射線研究発表会
- Invited
- Data Source
  KAKENHI-PROJECT-22K12369
[Presentation] Whole genome sequencing-based analysis of naturally occurring and radiation-induced mutations in human lymphocyte TK6 clones in culture2023
- Author(s)
  MILAI Enkhbaatar, Tsumbuukhuu Dulguun, 島田幹男, 松本義久
- Organizer
  日本放射線影響学会第66回大会
- Data Source
  KAKENHI-PROJECT-22K12369
[Presentation] Whole Genome Sequencing and Mutation Analysis of Human Lymphocyte TK6 Clones in Culture2023
- Author(s)
  Tsumbuukhuu Dulguun, MILAI Enkhbaatar, 島田幹男, 松本義久
- Organizer
  17th International Congress for Radiation Research
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-22K12369
[Presentation] Replication-associated DNA single-strand breaks are the source of PARP inhibitor sensitivity in XRCC1-deficient cells2023
- Author(s)
  今村力也, 齋藤瑞樹, 島田幹男, 松本義久
- Organizer
  日本放射線影響学会第66回大会
- Data Source
  KAKENHI-PROJECT-22K12369
[Presentation] Analysis of the phosphorylation mechanism of the C-terminus of XRCC4 in DNA double-strand break repair2023
- Author(s)
  村松麗斗, 塚田海馬, 西内巧, 島田幹男, 松本義久.
- Organizer
  日本原子力学会関東・甲越支部第21回若手研究者・技術者研究討論会
- Data Source
  KAKENHI-PROJECT-20H04334
[Presentation] Evaluation of DNA damage response and cell cycle status using Focicle reporter in human iPS cells and differentiated cells2023
- Author(s)
  島田幹男, 大塚健介, 松本義久
- Organizer
  日本放射線影響学会第66回大会
- Data Source
  KAKENHI-PROJECT-22K12369
[Presentation] Trace Element Analyzer in Single Human Cells Using Flow Cytometer and High Temperature Plasma Mass Spectrometer2023
- Author(s)
  Akitoshi Okino, Takashi Ohta, Yuya Shimizu, Kai Fukuchi, Motohide Aoki, Mikio Shimada, Yoshihisa Matsumoto, Tomonari Umemura, Takafumi Hirata
- Organizer
  第32回日本MRS年次大会, 国際シンポジウム: プラズマライフサイエンス
- Invited
- Data Source
  KAKENHI-PROJECT-22H04973
[Presentation] Whole genome sequencing-based analysis of low dose rate radiation-induced mutations in normal human fibroblast NB1RGB in culture2023
- Author(s)
  MILAI Enkhbaatar, Tsumbuukhuu Dulguun, 島田幹男, 松本義久
- Organizer
  The 7th International Symposium on the System of Radiological Protection (ICRP 2023)
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-22K12369
[Presentation] The Functional Analysis of Genetic Disease Factor APTX in DNA Double Strand Break Repair2023
- Author(s)
  Rikiya Imamura, Mizuki Saito, Mikio Shimada, Masamichi Ishiai, Yoshihisa Matsumoto
- Organizer
  International Symposium on Zero-Carbon Energy Systems
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20H04334
[Presentation] DNA末端リン酸化脱リン酸化酵素PNKPの機能解析と放射線増感効果の検討2023
- Author(s)
  島田幹男, 塚田海馬, 今村力也, 松本義久
- Organizer
  日本放射線腫瘍学会第60回生物部会学術大会
- Data Source
  KAKENHI-PROJECT-22K12369
[Presentation] 重粒子線による幹細胞のゲノム安定性への影響2023
- Author(s)
  島田幹男
- Organizer
  2022年度HIMAC成果発表会
- Data Source
  KAKENHI-PROJECT-22K12369
[Presentation] Phosphorylation of PNKP T118 by CDK is required for ionizing radiation induced DNA single and double strand break repair2023
- Author(s)
  島田幹男, 塚田海馬, 今村力也, 三宅智子, 松本義久
- Organizer
  17th International Congress for Radiation Research
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-22K12369
[Presentation] Trace Element Analyzer in Single Human Cells Using Flow Cytometer and High Temperature Plasma Mass Spectrometer2022
- Author(s)
  Akitoshi Okino, Takashi Ohta, Yuya Shimizu, Kai Fukuchi, Motohide Aoki, Mikio Shimada, Yoshihisa Matsumoto, Tomonari Umemura, Takafumi Hirata
- Organizer
  第32回日本MRS年次大会国際シンポジウム
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-22H04973
[Presentation] 多能性幹細胞における高LET放射線照射による細胞分裂への影響2022
- Author(s)
  島田幹男, 平山亮一, 松本義久
- Organizer
  第59回アイソトープ・放射線研究発表会
- Data Source
  KAKENHI-PROJECT-22K12369
[Presentation] Development of High-Throughput and High-Sensitive Single Cell Analysis System using Flow Cytometer and Inductively Coupled Plasma2022
- Author(s)
  Akitoshi Okino, Takashi Ohta, Yuya Shimizu, Kai Fukuchi, Motohide Aoki, Mikio Shimada, Yoshihisa Matsumoto, Tomonari Umemura
- Organizer
  International Congress on Pure & Applied Chemistry
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-22H04973
[Presentation] 遺伝性疾患原因遺伝子APTX のDNA 二本鎖切断修復での役割2022
- Author(s)
  今村力也, 齋藤瑞樹, 島田幹男, 石合正道, 松本義久.
- Organizer
  日本放射線影響学会第65回大会
- Data Source
  KAKENHI-PROJECT-20H04334
[Presentation] ヒト大脳オルガノイドを用いた放射線照射後のDNA損傷応答解析2022
- Author(s)
  島田　幹男
- Organizer
  日本放射線影響学会第65回大会
- Data Source
  KAKENHI-PROJECT-22K12369
[Presentation] Role of genetic disease factor APTX in DNA double strand repair2022
- Author(s)
  Rikiya Imamura, Mizuki Saito, Mikio Shimada, Masamichi Ishiai, Yoshihisa Matsumoto.
- Organizer
  5th Asian Congress of Radiation Research
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20H04334
[Presentation] XRCC4-like factor (XLF)のヒトリンパ芽球TKにおけるDNA二本鎖切断修復およびV(D)J組換え機能解析(The function of XRCC4-like factor (XLF) in DNA double-strand break repair and V(D)J recombination in himan lymphoblastoid TK6)2021
- Author(s)
  モウダクテャイティー, 塚田海馬, デイアニー, 島田幹男, 松本義久.
- Organizer
  日本放射線影響学会第64回大会
- Data Source
  KAKENHI-PROJECT-20H04334
[Presentation] iPS細胞由来組織細胞における放射線依存的突然変異計測系の確立(Establishment of a radiation-dependent mutation measurement system for human iPS cell-derived tissue cells)2021
- Author(s)
  徳宮巧実, 島田幹男, 柳原啓見, 神﨑訓枝, 三宅智子, 松本義久.
- Organizer
  日本放射線影響学会第64回大会
- Data Source
  KAKENHI-PROJECT-20H04334
[Presentation] Molecular characterization of radiosensitivity and radiation response of liver cancer cells2021
- Author(s)
  Enkhbaatar Milai, Yoshihisa Matsumoto, Mikio Shimada, Kaima Tsukada, Tomoko Miyake.
- Organizer
  日本放射線影響学会第64回大会
- Data Source
  KAKENHI-PROJECT-20H04334
[Presentation] 遺伝病原因遺伝子 APTX の DNA 損傷応答での役割 (The role of hereditary disease factor APTX in DNA damage response.)2021
- Author(s)
  今村力也, 齋藤瑞樹, 島田幹男, 石合正道, 松本義久.
- Organizer
  令和三年度第一回日本放射線影響学会・若手部会放射線影響研究会
- Data Source
  KAKENHI-PROJECT-20H04334
[Presentation] The role of DNA double-strand break repair through non-homologous end joining in the dose-rate effect in terms of clonogenic ability2021
- Author(s)
  Hisayo Tsuchiya, Mikio Shimada, Kaima Tsukada, Qingmei Meng, Junya Kobayashi, Yoshihisa Matsumoto.
- Organizer
  Institute for Environmental Sciences International Symposium
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20H04334
[Presentation] 高LET放射線照射はiPS細胞において多極性細胞分裂を誘導する(High LET radiation induces multipolar cell division in human induced pluripotent stem cells.)2021
- Author(s)
  島田幹男, 塚田海馬, 齊川昂太郎, 三宅智子, 平山亮一, 松本義久.
- Organizer
  日本放射線影響学会第64回大会
- Data Source
  KAKENHI-PROJECT-20H04334
[Presentation] 遺伝性疾患原因遺伝子APTXのDNA複製および複製ストレス下での役割(The role of hereditary disease factor APTX in DNA replication and replication stress)2021
- Author(s)
  今村力也, 齋藤瑞樹, 島田幹男, 石合正道, 松本義久.
- Organizer
  日本放射線影響学会第64回大会
- Data Source
  KAKENHI-PROJECT-20H04334
[Presentation] ヒト iPS 細胞由来組織細胞における放射線誘発突然変異計測系の確立 (Establishment of a radiation-induced mutation measurement system in human iPS cell- derived tissue cell.)2021
- Author(s)
  徳宮巧実, 島田幹男, 柳原啓見, 神崎訓枝, 三宅智子, 松本義久.
- Organizer
  令和三年度第一回日本放射線影響学会・若手部会放射線影響研究会
- Data Source
  KAKENHI-PROJECT-20H04334
[Presentation] DNA二重鎖修復タンパク質Ku欠損細胞における線量率効果2021
- Author(s)
  土屋尚代, 島田幹男, 塚田海馬, 孟慶梅, 小林純也, 松本義久.
- Organizer
  日本放射線腫瘍学会生物部会第58回学術大会
- Data Source
  KAKENHI-PROJECT-20H04334
[Presentation] ヒト細胞におけるアプラタキシン(APTX)のDNA損傷応答解析(Function of Aprataxin (APTX) in DNA damage response and repair in human cells)2021
- Author(s)
  神元梨穂, 今村力也, 島田幹男, 松本義久.
- Organizer
  日本放射線影響学会第64回大会
- Data Source
  KAKENHI-PROJECT-20H04334
[Presentation] XRCC4およびDNA-PKによるXRCC4のリン酸化のDNA二本鎖切断修復における役割(Role of XRCC4 and its phosphorylation by DNA-PK in DNA double-strand break repair)2021
- Author(s)
  齋藤瑞樹, 塚田海馬, 今村力也, 島田幹男, 松本義久.
- Organizer
  日本放射線影響学会第64回大会
- Data Source
  KAKENHI-PROJECT-20H04334
[Presentation] XRCC4 欠損細胞を用いた DNA 二本鎖修復効率の解析2021
- Author(s)
  齋藤瑞樹, 今村力也, 塚田海馬, 島田幹男, 松本義久.
- Organizer
  令和三年度第一回日本放射線影響学会・若手部会放射線影響研究会
- Data Source
  KAKENHI-PROJECT-20H04334
[Presentation] DNA複製中の岡崎フラグメント成熟におけるDNA修復酵素PNKPの役割(The role of polynucleotide kinase phosphatase (PNKP) in Okazaki fragment maturation during DNA replication)2021
- Author(s)
  塚田海馬, 今村力也, 齋藤瑞樹, 石合正道, 島田幹男, 松本義久.
- Organizer
  日本放射線影響学会第64回大会
- Data Source
  KAKENHI-PROJECT-20H04334
[Presentation] DNA修復酵素PNKPの天然変性領域が担う細胞安定性における役割.2020
- Author(s)
  齊川昂太郎, 塚田海馬, 今村力也, 島田幹男, 松本義久.
- Organizer
  日本放射線影響学会第63回大会
- Data Source
  KAKENHI-PROJECT-20H04334
[Presentation] ヒトiPS細胞由来組織細胞における放射線依存的突然変異頻度解析.2020
- Author(s)
  島田幹男, 神崎訓枝, 柳原啓見, 三宅智子, 松本義久.
- Organizer
  日本放射線影響学会第63回大会
- Data Source
  KAKENHI-PROJECT-20H04334
[Presentation] 肝臓がんの放射線感受性に関する分子特性.2020
- Author(s)
  Milai Enkhbaatar, 三宅智子, 塚田海馬, 島田幹男, 松本義久.
- Organizer
  日本放射線影響学会第63回大会
- Data Source
  KAKENHI-PROJECT-20H04334
[Presentation] DNA修復酵素PNKP欠損細胞の樹立とDNA損傷・複製ストレスにおける機能解析.2020
- Author(s)
  今村力也, 塚田海馬, 齊川昂太郎, 島田幹男, 松本義久.
- Organizer
  日本放射線影響学会第63回大会
- Data Source
  KAKENHI-PROJECT-20H04334
[Presentation] 蛍光ライブセルイメージングを用いたDNA修復酵素PNKP制御メカニズム解析.2020
- Author(s)
  塚田海馬, 今村力也, 島田幹男, 石合正道, 松本義久.
- Organizer
  日本放射線影響学会第63回大会
- Data Source
  KAKENHI-PROJECT-20H04334
[Presentation] Ionizing radiation induced-microcephaly depends on dissociation of apical structure during embryonic development of the mouse cerebral cortex.2011
- Author(s)
  M Shimada, JN Puivers, F Matsuzaki, T Matsumoto, K Komatsu
- Organizer
  International Congress of Radiation Research
- Place of Presentation
  Walsaw
- Year and Date
  2011-08-29
- Data Source
  KAKENHI-PROJECT-22710054
[Presentation] High LET重粒子線照射時の中心体複製への影響の検討2011
- Author(s)
  島田幹男、平山亮一、小松賢
- Organizer
  平成二十二年度HIMAC共同利用研究成果発表会
- Place of Presentation
  千葉
- Year and Date
  2011-04-23
- Data Source
  KAKENHI-PROJECT-22710054
[Presentation] Ionizing radiation induced-microcephaly depends on dissociation of apical structure during embryonic development of the mouse cerebral cortex2011
- Author(s)
  M Shimada, JN Puivers, F Matsuzaki, T Matsumoto, K Komatsu
- Organizer
  International Congress of Radiation Research
- Place of Presentation
  ワルシャワ、ポーランド
- Year and Date
  2011-08-29
- Data Source
  KAKENHI-PROJECT-22710054
[Presentation] NBS1/BRCA1 pathway dependent ubuquitination of gamma-tubulin is involved in centrosome maintenance.2011
- Author(s)
  Mikio shimada, Kenshi Komatsu
- Organizer
  Keystone Symposia Genomic Instability and DNA Repair.
- Place of Presentation
  アメリカ、コロラド
- Year and Date
  2011-02-03
- Data Source
  KAKENHI-PROJECT-22710054
[Presentation] Centrosome maintenance by NBS1/BRCA1 dependent ubiquitination ofγ-tubulin2011
- Author(s)
  Mikio Shimada and Kenshi Komatsu
- Organizer
  Keystone symposia, Genomic Instability and DNA repair
- Place of Presentation
  Keystone, Colorado
- Year and Date
  2011-02-03
- Data Source
  KAKENHI-PROJECT-22710054
[Presentation] 放射線誘発小頭症における中心体による神経幹細胞制御機構の解析2011
- Author(s)
  島田幹男、松崎文雄、小松賢志
- Organizer
  第一回放射線神経生物研究集会
- Place of Presentation
  群馬
- Year and Date
  2011-01-29
- Data Source
  KAKENHI-PROJECT-22710054
[Presentation] High LET重粒子線照射時の中心体複製への影響の検討2011
- Author(s)
  島田幹男、平山亮一、小松賢志
- Organizer
  平成二十三年度HIMAC共同利用研究成果発表会
- Place of Presentation
  千葉
- Year and Date
  2011-04-23
- Data Source
  KAKENHI-PROJECT-22710054
[Presentation] 放射線誘発小頭症における中心体による神経幹細胞制御機構の解析2011
- Author(s)
  島田幹男、松崎文雄、小松賢志
- Organizer
  第一回放射線神経生物研究集会
- Place of Presentation
  前橋
- Year and Date
  2011-01-29
- Data Source
  KAKENHI-PROJECT-22710054
[Presentation] 中心体過剰複製と線量率効果の解析2010
- Author(s)
  島田幹男、小林純也、小松賢志
- Organizer
  第53回日本放射線影響学会
- Place of Presentation
  京都
- Year and Date
  2010-10-21
- Data Source
  KAKENHI-PROJECT-22710054
[Presentation] High LET重粒子線照射時の中心体複製への影響の検討2010
- Author(s)
  島田幹男、平山亮一、小松賢志
- Organizer
  平成二十一年度HIMAC共同利用研究成果発表会
- Place of Presentation
  千葉
- Data Source
  KAKENHI-PROJECT-22710054
[Presentation] Novel role of DNA repair protein FANCD2 in centrosome maintenance2010
- Author(s)
  島田幹男、小林純也、小松賢志
- Organizer
  第62回日本細胞生物学会
- Place of Presentation
  大阪
- Year and Date
  2010-05-22
- Data Source
  KAKENHI-PROJECT-22710054
[Presentation] Novel role of DNA repair protein FANCD2 in centrosome maintenance2010
- Author(s)
  島田幹男、小林純也、小松賢志
- Organizer
  日本細胞生物学会
- Place of Presentation
  大阪
- Year and Date
  2010-05-22
- Data Source
  KAKENHI-PROJECT-22710054
[Presentation] Centrosome maintenance by NBS1/BRCA1-dependent ubiquitination ofγ-tubulin2010
- Author(s)
  Mikio shimada and Kenshi Komatsu
- Organizer
  RBC International Symposium
- Place of Presentation
  Kyoto
- Year and Date
  2010-10-22
- Data Source
  KAKENHI-PROJECT-22710054
[Presentation] Novel role of DNA repair protein FANCD2 in centrosome maintenance2010
- Author(s)
  島田幹男、小林純也、小松賢志
- Organizer
  第67回日本癌学会学術総会
- Place of Presentation
  大阪
- Year and Date
  2010-09-22
- Data Source
  KAKENHI-PROJECT-22710054
[Presentation] Centrosome maintenance by NBS1/BRCA1-dependent ubiquitination of γ-tubulin2010
- Author(s)
  Mikio shimada, Kenshi Komatsu
- Organizer
  RBC International Symposium
- Place of Presentation
  京都(招待講演)
- Year and Date
  2010-10-22
- Data Source
  KAKENHI-PROJECT-22710054

1. Matsumoto Yoshihisa (20302672)

# of Collaborated Projects: 3 results

# of Collaborated Products: 31 results
2. 沖野晃俊 (60262276)

# of Collaborated Projects: 2 results

# of Collaborated Products: 3 results
3. 平田岳史 (10251612)

# of Collaborated Projects: 2 results

# of Collaborated Products: 2 results
4. 梅村知也 (10312901)

# of Collaborated Projects: 2 results

# of Collaborated Products: 3 results
5. 青木元秀 (30418917)

# of Collaborated Projects: 2 results

# of Collaborated Products: 3 results
6. 高松利寛 (10734949)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
7. 柳川由紀 (90432591)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
8. 岩井貴弘 (90756694)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
9. 横谷明徳 (10354987)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
10. 泉雄大 (20595772)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
11. 松尾光一 (40403620)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
12. 林宣宏 (80267955)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
13. 石合正道 (90298844)

# of Collaborated Projects: 1 results

# of Collaborated Products: 9 results
14. 青井貴之 (00546997)

# of Collaborated Projects: 1 results

# of Collaborated Products: 3 results
15. 成川知弘 (10265473)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
16. 壷井基裕 (60411774)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
17. 千葉光一 (20281066)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
18. KATO Akihiro

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
19. 小林純也

# of Collaborated Projects: 0 results

# of Collaborated Products: 3 results

Shimada Mikio 島田 幹男

SHIMADA Mikio 島田 幹男

Research Projects

Research Products

Co-Researchers

高LET放射線による細胞分裂死誘導メカニズムの解明とがん治療への応用Principal Investigator

Principal Investigator

Project Period (FY)

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Review Section

Research Institution

Development of ultra-sensitive high-throughput single cell elemental analysis system and creation of single cell metallomics

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Development of a high-sensitive, high-throughput single-cell elemental analysis system directly connected to a flow cytometer

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Biological Significance of DNA-PK in the Orchestration of Cellular Response to DNA Double-strand Breaks

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

The role of DNA repair factor FNACD2 in centrosome duplication maintenancePrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] Implication of E3 ligase RAD18 in UV-induced mutagenesis in human induced pluripotent stem cells and neuronal progenitor cells.2023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] APTX acts in DNA double-strand break repair in a manner distinct from XRCC42023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] The role of DNA double-strand break repair through non-homologous end joining in the dose-rate effect in terms of clonogenic ability2022

Author(s)

Journal Title

Data Source

[Journal Article] THE ROLE OF DNA DOUBLE-STRAND BREAK REPAIR THROUGH NON-HOMOLOGOUS END JOINING IN THE DOSE-RATE EFFECT IN TERMS OF CLONOGENIC ABILITY2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] α-glucosyl-rutin activates immediate early genes in human induced pluripotent stem cells.2021

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Functional analysis of XRCC4 mutations in reported microcephaly and growth defect patients in terms of radiosensitivity.2021

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Diminished or inversed dose-rate effect on clonogenic ability in Ku-deficient rodent cells.2021

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Phosphorylation of PNKP mediated by CDKs promotes end-processing of Okazaki fragments during DNA replication2021

Author(s)

Journal Title

DOI

Data Source

[Journal Article] DNA-dependent protein kinase catalytic subunit: The sensor for DNA double-strand breaks structurally and functionally related to Ataxia-Telangiectasia Mutated.2021

Author(s)

Journal Title

DOI

Data Source

[Journal Article] The FHA domain of PNKP is essential for its recruitment to DNA damage sites and maintenance of genome stability2020

Shimada Mikio 島田幹男

SHIMADA Mikio 島田幹男