BEPPU Hideyuki 別府秀幸

Researcher Number	20550479
Affiliation (based on the past Project Information) *help	2012: 富山大学, 大学院医学薬学研究部(医学), 准教授 2009 – 2012: University of Toyama, 大学院・医学薬学研究部(医学), 准教授 2011: 富山大学, 医学薬学研究部(医学), 准教授 2010: University of Toyama, 准教授
Review Section/Research Field	Principal Investigator Pathological medical chemistry Except Principal Investigator Fusional basic brain science
Keywords	Principal Investigator 遺伝子改変マウス / 癌 / 受容体 / BMP / 上皮間質相互作用 / 大腸ポリープ / BMP受容体 / 骨形成因子 / 間質細胞 / 大腸腫瘍 … More Except Principal Investigator … More 発達障害 / ES細胞 / ATRX症候群 / クロマチンロモデリング / 精神運動発達障害 / ＥＳ細胞 / コンデショナルノックアウトマウス / ＡＴＲ-Ｘ症候群 / 精神遅滞 / 応用動物 / 脳神経疾患 / 神経科学 / スパイン / ノックアウトマウス / クロマチンリモデリング / エピジェネテイクス / 脳発達障害 Less

Molecular pathological mechanisms of the brain development disorder using the chromatin-remodeling molecule ATRX gene knockout mouse
- Principal Investigator
  
  KITAJIMA Isao
- Project Period (FY)
  2011 – 2013
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Fusional basic brain science
- Research Institution
  University of Toyama
Molecular basis of proliferative diseases associated with BMP receptor mutationsPrincipal Investigator
- Principal Investigator
  
  BEPPU Hideyuki
- Project Period (FY)
  2010 – 2012
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Pathological medical chemistry
- Research Institution
  University of Toyama
BMPR2変異間質細胞による大腸上皮細胞増殖に関わる因子の同定Principal Investigator
- Principal Investigator
  
  別府秀幸
- Project Period (FY)
  2009 – 2010
- Research Category
  
  Grant-in-Aid for Research Activity Start-up
- Research Field
  
  Pathological medical chemistry
- Research Institution
  University of Toyama

All 2013 2012 2011 2010 2009

All Journal Article Presentation Book

[Book] 実験医学特集 TGF-βファミリー2010
- Author(s)
  別府秀幸
- Total Pages
  6
- Publisher
  羊土社
- Data Source
  KAKENHI-PROJECT-21890082
[Journal Article] Constitutively Active ALK2 Receptor Mutants Require Type II Receptor Cooperation2013
- Author(s)
  Bagarova J, Vonner AJ, Armstrong KA, Borgermann J, Lai CS, Deng DY, Beppu H, Alfano I, Filippakopoulos P, Morrell NW, Bullock AN, Knaus P, Mishina Y, Yu PB
- Journal Title
  
  Mol Cell Biol
  
  Volume: 33(12) Issue: 12 Pages: 2413-24
- DOI
  10.1128/mcb.01595-12
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22390059
[Journal Article] Smad7-modified alleles by various gene-targeting strategies2013
- Author(s)
  Beppu H
- Journal Title
  
  J Biochem
  
  Volume: 153(5) Issue: 5 Pages: 399-401
- DOI
  10.1093/jb/mvt020
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22390059
[Journal Article] A rapid and high-throughput quantitation assay of the nuclear factor κB activity using fluorescence correlation spectroscopy in the setting of clinical laboratories2013
- Author(s)
  Harada K, Mikuni S, Beppu H, Niimi H, Abe S, Hano N, Yamagata K, Kinjo M, Kitajima I
- Journal Title
  
  PLoS One
  
  Volume: 8(10)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23300147
[Journal Article] Basolateral BMP signaling in polarized epithelial cells2013
- Author(s)
  Saitoh M, Shirakihara T, Fukasawa A, Horiguchi K, Sakamoto K, Sugiya H, Beppu H, Fujita Y, Morita I, Miyazono K, Miyazawa K.
- Journal Title
  
  PLoS One
  
  Volume: 13 Issue: 5 Pages: 1-10
- DOI
  10.1371/journal.pone.0062659
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PLANNED-22112002, KAKENHI-PROJECT-22390059, KAKENHI-PROJECT-24390419, KAKENHI-PROJECT-24580433
[Journal Article] A pair of transmembrane receptors essential for the retention and pigmentation of hair2012
- Author(s)
  Han R, Beppu H, Lee YK, Georgopoulos K, Larue L, Li E, Weiner L, Brissette JL
- Journal Title
  
  Genesis.
  
  Volume: Nov;50(11) Issue: 11 Pages: 783-800
- DOI
  10.1002/dvg.22039
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22390059
[Journal Article] BMPシグナル伝達異常と疾患との関わり(総説)2012
- Author(s)
  別府秀幸
- Journal Title
  
  臨床化学
  
  Volume: 41(1) Pages: 47-53
- Data Source
  KAKENHI-PROJECT-22390059
[Journal Article] BMPR-II is dispensable for formation of the limb skeleton2011
- Author(s)
  Gamer LW, Tsuji K, Cox K, Capelo LP, Lowery J, Beppu H, Rosen V
- Journal Title
  
  Genesis
  
  Volume: 49(9) Issue: 9 Pages: 719-24
- DOI
  10.1002/dvg.20761
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22390059
[Journal Article] Transgenic and knockout mouse models for pulmonary hypertension.2011
- Author(s)
  Beppu H.
- Journal Title
  
  Drug Discovery Today : Disease models (Review)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22390059
[Journal Article] Reduced expression of the ATRX gene, a chromatin-remodeling factor, causes hippocampal dysfunction in mice2011
- Author(s)
  Nogami T1, Beppu H, Tokoro T, Moriguchi S, Shioda N, Fukunaga K, Ohtsuka T, Ishii Y, Sasahara M, Shimada Y, Nishijo H, Li E, Kitajima I
- Journal Title
  
  Hippocampus
  
  Volume: 21(6) Pages: 678-687
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23300147
[Journal Article] Aberrant calcium/calmodulin-dependent protein kinase II (CaMKII) activity is associated with abnormal dendritic spine morphology in the ATRX mutant mouse brain2011
- Author(s)
  Shioda N1, Beppu H, Fukuda T, Li E, Kitajima I, Fukunaga K
- Journal Title
  
  J Neurosci
  
  Volume: 31(1) Pages: 346-358
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23300147
[Presentation] BMPR2-deficient fibroblast cells exhibit augmented activation of NF-kB in response to TNF.2013
- Author(s)
  Beppu H, Kitajima I
- Organizer
  日本癌学会
- Place of Presentation
  札幌
- Invited
- Data Source
  KAKENHI-PROJECT-23300147
[Presentation] BMPR2-deficient fibroblast cells exhibit augmented NF-kB signaling in response to TNF-alpha2012
- Author(s)
  Beppu H
- Organizer
  The 1st International Symposium by JSPS Core-to-Core Program (招待講演)
- Place of Presentation
  Tokyo (Japan)
- Year and Date
  2012-01-24
- Data Source
  KAKENHI-PROJECT-22390059
[Presentation] BMPR2変異マウスにおける肺血管異常とその細胞内シグナル伝達異常2012
- Author(s)
  別府秀幸
- Organizer
  PHサミット2012(招待講演)
- Place of Presentation
  岡山
- Data Source
  KAKENHI-PROJECT-22390059
[Presentation] Augmented NF-kB signaling in BMPR2 deficient cells as the model for juvenile polyposis syndrome2012
- Author(s)
  Beppu H
- Organizer
  TGF-beta meeting
- Place of Presentation
  Leiden Medical Center (The Netherlands)
- Data Source
  KAKENHI-PROJECT-22390059
[Presentation] BMPR2変異マウスにおける肺血管異常とその細胞内シグナル伝達異常2012
- Author(s)
  別府秀幸
- Organizer
  PHサミット2012
- Place of Presentation
  岡山
- Invited
- Data Source
  KAKENHI-PROJECT-22390059
[Presentation] Augmented NF-kB signaling in BMPR2 deficient cells as the model for juvenile polyposis syndrome.2012
- Author(s)
  Beppu H
- Organizer
  TGF-beta Meeting
- Place of Presentation
  Leiden Medical Center (The Netherlands)
- Data Source
  KAKENHI-PROJECT-22390059
[Presentation] BMPR2欠損線維芽細胞における亢進したTNF刺激反応性とNF-kB活性化2012
- Author(s)
  別府秀幸
- Organizer
  第71回日本癌学会学術総会
- Place of Presentation
  札幌
- Data Source
  KAKENHI-PROJECT-22390059
[Presentation] Augmented NF-kB signaling in BMPR2 deficient cells as the model for juvenile polyposis syndrome.2012
- Author(s)
  Beppu H,Kitajima I
- Organizer
  International 2013 TGF-b Meeting.
- Place of Presentation
  Leiden, The Netherlands.
- Invited
- Data Source
  KAKENHI-PROJECT-23300147
[Presentation] BMPR2-deficient fibroblast cells exhibit augmented NF-kB signaling in response to TNF-alpha2012
- Author(s)
  Beppu H
- Organizer
  The 1^<st> International Symposium by JSPS Core-to-Core Program
- Place of Presentation
  Tokyo, Japan(招待講演)
- Year and Date
  2012-01-24
- Data Source
  KAKENHI-PROJECT-22390059
[Presentation] Reduced expression of the ATRX gene, A chromatin-remodeling factor, causes abnormal behaviors and learning impairment2011
- Author(s)
  Kitajima I, Beppu H, Nogami T, Shoda N, Fukunaga K
- Organizer
  XXth World Congress of Neurology
- Place of Presentation
  Marrakesh, Morocco
- Data Source
  KAKENHI-PROJECT-23300147
[Presentation] BMPR2-deficient fibroblast cells promote proliferation of epithelial cells in a cell culture system2011
- Author(s)
  Beppu H
- Organizer
  FASEB Summer Research Conferences
- Place of Presentation
  Barga (Italy)
- Data Source
  KAKENHI-PROJECT-22390059
[Presentation] The role of BMPR2 in the development of colorectal polyps2011
- Author(s)
  Beppu H
- Organizer
  TGF-beta meeting in Uppsala
- Place of Presentation
  Uppsala (Sweden)
- Year and Date
  2011-08-20
- Data Source
  KAKENHI-PROJECT-22390059
[Presentation] Reduced expression of the ATRX gene, A chromatin-remodeling factor, causes abnormal behaviors and learning impainnent2011
- Author(s)
  Kitajima I, Beppu H, Nogami T,Shoda N, Fukunaga K
- Organizer
  XXth World Congress of Neurology
- Place of Presentation
  Marrakesh, Morocco
- Year and Date
  2011-11-17
- Data Source
  KAKENHI-PROJECT-23300147
[Presentation] The role of BMPR2-deficient stromal cells in tumorigenesis of colonic eithelial cells.2010
- Author(s)
  別府秀幸
- Organizer
  第69回日本癌学会学術総会
- Place of Presentation
  大阪国際会議場
- Year and Date
  2010-09-23
- Data Source
  KAKENHI-PROJECT-22390059
[Presentation] 肺高血圧病態と心形態形成に関わる共通の分子基盤2009
- Author(s)
  別府秀幸
- Organizer
  第12回小児心血管分子医学研究会
- Place of Presentation
  神戸国際会議場(兵庫県)
- Year and Date
  2009-07-15
- Data Source
  KAKENHI-PROJECT-21890082

1. KITAJIMA Isao (50214797)

# of Collaborated Projects: 1 results

# of Collaborated Products: 7 results
2. MORI Hisashi (00239617)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
3. FUKUNAGA Kohji (90136721)

# of Collaborated Projects: 1 results

# of Collaborated Products: 4 results
4. 宮園浩平

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

BEPPU Hideyuki 別府 秀幸

Research Projects

Research Products

Co-Researchers

Molecular pathological mechanisms of the brain development disorder using the chromatin-remodeling molecule ATRX gene knockout mouse

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Molecular basis of proliferative diseases associated with BMP receptor mutationsPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

BMPR2変異間質細胞による大腸上皮細胞増殖に関わる因子の同定Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Book] 実験医学 特集 TGF-βファミリー2010

Author(s)

Total Pages

Publisher

Data Source

[Journal Article] Constitutively Active ALK2 Receptor Mutants Require Type II Receptor Cooperation2013

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Smad7-modified alleles by various gene-targeting strategies2013

Author(s)

Journal Title

DOI

Data Source

[Journal Article] A rapid and high-throughput quantitation assay of the nuclear factor κB activity using fluorescence correlation spectroscopy in the setting of clinical laboratories2013

Author(s)

Journal Title

Data Source

[Journal Article] Basolateral BMP signaling in polarized epithelial cells2013

Author(s)

Journal Title

DOI

Data Source

[Journal Article] A pair of transmembrane receptors essential for the retention and pigmentation of hair2012

Author(s)

Journal Title

DOI

Data Source

[Journal Article] BMPシグナル伝達異常と疾患との関わり(総説)2012

Author(s)

Journal Title

Data Source

[Journal Article] BMPR-II is dispensable for formation of the limb skeleton2011

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Transgenic and knockout mouse models for pulmonary hypertension.2011

Author(s)

Journal Title

Data Source

[Journal Article] Reduced expression of the ATRX gene, a chromatin-remodeling factor, causes hippocampal dysfunction in mice2011

Author(s)

Journal Title

Data Source

[Journal Article] Aberrant calcium/calmodulin-dependent protein kinase II (CaMKII) activity is associated with abnormal dendritic spine morphology in the ATRX mutant mouse brain2011

Author(s)

Journal Title

Data Source

[Presentation] BMPR2-deficient fibroblast cells exhibit augmented activation of NF-kB in response to TNF.2013

Author(s)

Organizer

Place of Presentation

Data Source

[Presentation] BMPR2-deficient fibroblast cells exhibit augmented NF-kB signaling in response to TNF-alpha2012

Author(s)

Organizer

BEPPU Hideyuki 別府秀幸

[Book] 実験医学特集 TGF-βファミリー2010