Kuga Takahisa 久家貴寿

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KUGA Takahisa 久家貴寿

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Researcher Number	20551857
Other IDs
Affiliation (Current)	2025: 摂南大学, 薬学部, 准教授 2025: 国立研究開発法人医薬基盤・健康・栄養研究所, 医薬基盤研究所プロテオームリサーチプロジェクト, 協力研究員
Affiliation (based on the past Project Information) *help	2021 – 2024: 摂南大学, 薬学部, 講師 2017 – 2019: 摂南大学, 薬学部, 助教 2014 – 2018: 京都薬科大学, 薬学部, 助教 2011 – 2013: 独立行政法人医薬基盤研究所, 創薬基盤研究部, 研究員 2011: 独立行政法人医薬基盤研究所, プロテオームリサーチプロジェクト, 研究員 2010: 独立行政法人医薬基盤研究所, 創薬基盤研究部・プロテオームリサーチプロジェクト, 研究員
Review Section/Research Field	Principal Investigator Basic Section 57020:Oral pathobiological science-related / Biological pharmacy / Medical pharmacy / Laboratory medicine Except Principal Investigator Biological pharmacy
Keywords	Principal Investigator FAM83H / エナメル質形成不全症 / ケラチン骨格 / エナメル質 / ケラチン / CK1 / 歯 / 大腸がん / バイオマーカー / タンパク質リン酸化 … More / 大腸癌 / がん / スプライシング / 優性遺伝性低石灰化型エナメル質形成不全症 / 細胞間接着 / 皮膚 / ADHCAI / デスモソーム / カゼインキナーゼI / カゼインキナーゼ1 / 細胞接着阻止 / 接着阻止 / プロテオーム / キナーゼ / EGFR / セツキシマブ / オーダーメード医療 / 血中バイオマーカー / SRM法 / Phospho-iTRAQ法 / プロテオーム解析 / 腫瘍検査学 … More Except Principal Investigator Src / 染色体分配 / 細胞周期 / v-Src / チロシンリン酸化 / 細胞分裂 Less

FAM83H変異体の細胞内異所局在化とエナメル質形成不全症との因果関係解明研究Principal Investigator
- Principal Investigator
  
  久家貴寿
- Project Period (FY)
  2024 – 2026
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 57020:Oral pathobiological science-related
- Research Institution
  Setsunan University
FAM83H変異タンパク質のリンカー機能破綻とエナメル質形成不全症との関係性Principal Investigator
- Principal Investigator
  
  久家貴寿
- Project Period (FY)
  2021 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 57020:Oral pathobiological science-related
- Research Institution
  Setsunan University
Analysis of FAM83H gene-modified mice to reveal the mechanism of amelogenesis imperfectPrincipal Investigator
- Principal Investigator
  
  Kuga Takahisa
- Project Period (FY)
  2017 – 2019
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Biological pharmacy
- Research Institution
  Setsunan University
Regulation of cell division by tyrosine phosphorylation signaling
- Principal Investigator
  
  Nakayama Yuji
- Project Period (FY)
  2016 – 2018
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Biological pharmacy
- Research Institution
  Kyoto Pharmaceutical University
Analysis of the mechanism by which mutations of the FAM83H gene cause amelogenesis imperfectaPrincipal Investigator
- Principal Investigator
  
  Kuga Takahisa
- Project Period (FY)
  2014 – 2016
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Biological pharmacy
- Research Institution
  Kyoto Pharmaceutical University
Discovery of protein phosphorylation markers to predict the efficacy of anti-EGFR antibody drugs in colorectal cancer patientsPrincipal Investigator
- Principal Investigator
  
  KUGA Takahisa
- Project Period (FY)
  2012 – 2013
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Medical pharmacy
- Research Institution
  独立行政法人医薬基盤研究所
Discovery of biomarkers for early colon cancer using a phospho-proteomic approachPrincipal Investigator
- Principal Investigator
  
  KUGA Takahisa
- Project Period (FY)
  2010 – 2011
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Laboratory medicine
- Research Institution
  独立行政法人医薬基盤研究所

[Journal Article] Phosphotyrosine proteomics in cells synchronized at monopolar cytokinesis reveals EphA2 as functioning in cytokinesis2023
- Author(s)
  Hasegawa Nanami、Hongo Mayue、Okada Misaki、Kuga Takahisa、Abe Yuichi、Adachi Jun、Tomonaga Takeshi、Yamaguchi Naoto、Nakayama Yuji
- Journal Title
  
  Experimental Cell Research
  
  Volume: 432 Issue: 1 Pages: 113783-113783
- DOI
  10.1016/j.yexcr.2023.113783
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21K09865
[Journal Article] The conserved C-terminal residues of FAM83H are required for the recruitment of casein kinase 1 to the keratin cytoskeleton2022
- Author(s)
  Kuga Takahisa、Inoue Naoki、Sometani Kensuke、Murataka Shino、Saraya Minami、Sugita Rina、Mikami Toshinari、Takeda Yasunori、Taniguchi Masanari、Nishida Kentaro、Yamagishi Nobuyuki
- Journal Title
  
  Scientific Reports
  
  Volume: 12 Issue: 1 Pages: 11819-11819
- DOI
  10.1038/s41598-022-16153-y
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-21K09865
[Journal Article] Cellular concentrations of plasmalogen species containing a polyunsaturated fatty acid significantly increase under hypoxia in human colorectal cancer, Caco2 cells2022
- Author(s)
  Tamiya-Koizumi Keiko、Otoki Yurika、Nakagawa Kiyotaka、Kannagi Reiji、Mizutani Naoki、Suzuki Motoshi、Kyogashima Mamoru、Iwaki Soichiro、Aoyama Mineyoshi、Murate Takashi、Kitatani Kazuyuki、Kuga Takahisa、Mizutani Yasuyoshi、Tokumura Akira
- Journal Title
  
  Biochemical and Biophysical Research Communications
  
  Volume: 611 Pages: 1-7
- DOI
  10.1016/j.bbrc.2022.04.061
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18H02698, KAKENHI-PROJECT-20K08211, KAKENHI-PROJECT-21K09865
[Journal Article] Depletion of Csk preferentially reduces the protein level of LynA in a Cbl-dependent manner in cancer cells2020
- Author(s)
  Kuga T, Yamane Y, Hayashi S, Taniguchi M, Yamaguchi N, Yamagishi N
- Journal Title
  
  Scientific Reports
  
  Volume: -
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K08293
[Journal Article] Desuppression of TGF-β signaling via nuclear c-Abl-mediated phosphorylation of TIF1γ/TRIM33 at Tyr-524, -610, and -1048.2019
- Author(s)
  Yuki R, Tatewaki T, Yamaguchi N, Aoyama K, Honda T, Kubota S, Morii M, Manabe I, Kuga T, Tomonaga T, Yamaguchi N
- Journal Title
  
  Oncogene
  
  Volume: 38 Issue: 5 Pages: 637-655
- DOI
  10.1038/s41388-018-0481-z
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17K08293, KAKENHI-PROJECT-16J04363, KAKENHI-PROJECT-17J02389, KAKENHI-PROJECT-18J01777, KAKENHI-PROJECT-16K08227, KAKENHI-PROJECT-17K15985, KAKENHI-PROJECT-18K16078, KAKENHI-PROJECT-16H06276
[Journal Article] Hsp105α suppresses Adriamycin-induced cell death via nuclear localization signal-dependent nuclear accumulation2019
- Author(s)
  Yamane T, Saito Y, Teshima H, Hagino M, Kakihana A, Sato S, Shimada M, Kato Y, Kuga T, Yamagishi N, Nakayama Y.
- Journal Title
  
  J. Cell. Biochem.
  
  Volume: 120 Issue: 10 Pages: 17951-17962
- DOI
  10.1002/jcb.29062
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18K06672, KAKENHI-PROJECT-17K08293
[Journal Article] Air-drying of cells enables visualization of antiparallel microtubule overlaps in the spindle midzone.2018
- Author(s)
  Ifuji A, Kuga T, Nakayama Y
- Journal Title
  
  MethodsX
  
  Volume: 5 Pages: 431-437
- DOI
  10.1016/j.mex.2018.04.011
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17K08293, KAKENHI-PROJECT-16K08253
[Journal Article] The tyrosine kinase v-Src causes mitotic slippage by phosphorylating an inhibitory tyrosine residue of Cdk1.2018
- Author(s)
  Horiuchi M, Kuga T, Saito Y, Nagano M, Adachi J, Tomonaga T, Yamaguchi N, Nakayama Y
- Journal Title
  
  Journal of Biological Chemistry
  
  Volume: 293 Issue: 40 Pages: 15524-15537
- DOI
  10.1074/jbc.ra118.002784
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17K08293, KAKENHI-PROJECT-16K08253
[Journal Article] Src acts as an effector for Ku70-dependent suppression of apoptosis through phosphorylation of Ku70 at Tyr-5302017
- Author(s)
  Morii, M., Kubota, S., Honda, T., Yuki, R., Morinaga, T., Kuga, T., Tomonaga, T., Yamaguchi, N.-t., and Yamaguchi, N.
- Journal Title
  
  Journal of Biological Chemistry
  
  Volume: 292 Issue: 5 Pages: 1648-1665
- DOI
  10.1074/jbc.m116.753202
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16H06672, KAKENHI-PROJECT-16J04141, KAKENHI-PROJECT-16J04363, KAKENHI-PROJECT-26460081, KAKENHI-PROJECT-15K07922, KAKENHI-PROJECT-16K08227, KAKENHI-PROJECT-17J02389, KAKENHI-PROJECT-15K19545
[Journal Article] A novel immunofluorescence method to visualize microtubules in the antiparallel overlaps of microtubule-plus ends in the anaphase and telophase midzone2017
- Author(s)
  Ifuji Aya、Kuga Takahisa、Kaibori Yuichiro、Saito Youhei、Nakayama Yuji
- Journal Title
  
  Experimental Cell Research
  
  Volume: 360 Issue: 2 Pages: 347-357
- DOI
  10.1016/j.yexcr.2017.09.025
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16K08253, KAKENHI-PROJECT-17K08293
[Journal Article] Requirement of Hsp105 in CoCl2-induced HIF-1α accumulation and transcriptional activation2017
- Author(s)
  Mikami H, Saito Y, Okamoto N, Kakihana A, Kuga T, Nakayama Y
- Journal Title
  
  Experimental Cell Research
  
  Volume: 352 Issue: 2 Pages: 225-233
- DOI
  10.1016/j.yexcr.2017.02.004
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-26460081, KAKENHI-PROJECT-26870701
[Journal Article] v-Src-induced nuclear localization of YAP is involved in multipolar spindle formation in tetraploid cells2017
- Author(s)
  Kakae K, Ikeuchi M, Kuga T, Saito Y, Yamaguchi N, Nakayama Y
- Journal Title
  
  Cell Signalling
  
  Volume: 30 Pages: 19-29
- DOI
  10.1016/j.cellsig.2016.11.014
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-26460081, KAKENHI-PROJECT-15K07922, KAKENHI-PROJECT-16K08253
[Journal Article] Deep Phospho- and Phosphotyrosine Proteomics Identified Active Kinases and Phosphorylation Networks in Colorectal Cancer Cell Lines Resistant to Cetuximab2017
- Author(s)
  Abe Yuichi、Nagano Maiko、Kuga Takahisa、Tada Asa、Isoyama Junko、Adachi Jun、Tomonaga Takeshi
- Journal Title
  
  Scientific Reports
  
  Volume: 7 Issue: 1 Pages: 10463-10463
- DOI
  10.1038/s41598-017-10478-9
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K08293, KAKENHI-PROJECT-16H04707
[Journal Article] Tyrosine Phosphorylation of the Pioneer Transcription Factor FoxA1 Promotes Activation of Estrogen Signaling.2017
- Author(s)
  Noritaka Yamaguchi, Misato Shibazaki, Chiaki Yamada, Erina Anzai, Mariko Morii, Yuji Nakayama, Takahisa Kuga, Yuuki Hashimoto, Takeshi Tomonaga, and Naoto Yamaguchi.
- Journal Title
  
  Journal of Cellular Biochemistry
  
  Volume: 118 Issue: 6 Pages: 1453-1461
- DOI
  10.1002/jcb.25804
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-16J04363, KAKENHI-PROJECT-26460081, KAKENHI-PROJECT-15K07922, KAKENHI-PROJECT-16K08227
[Journal Article] Enhancement of TGF-β-induced Smad3 activity by c-Abl-mediated tyrosine phosphorylation of its coactivator SKI-interacting protein (SKIP).2017
- Author(s)
  Kuki K, Yamaguchi N, Iwasawa S, Takakura Y, Aoyama K, Yuki R, Nakayama Y, Kuga T, Hashimoto Y, Tomonaga T, Yamaguchi N
- Journal Title
  
  Biochemical and biophysical research communications
  
  Volume: 490 Issue: 3 Pages: 1045-1051
- DOI
  10.1016/j.bbrc.2017.06.163
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-16K08227, KAKENHI-PROJECT-17K08293, KAKENHI-PROJECT-17K15985, KAKENHI-PROJECT-15K07922, KAKENHI-PROJECT-16K19565
[Journal Article] Casein kinase 1 is recruited to nuclear speckles by FAM83H and SON2016
- Author(s)
  Kuga T, Kume H, Adachi J, Kawasaki N, Shimizu M, Hoshino I, Matsubara H, Saito Y, Nakayama Y, Tomonaga T
- Journal Title
  
  Scientific Reports
  
  Volume: 6 Issue: 1 Pages: 34472-34472
- DOI
  10.1038/srep34472
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-26460081
[Journal Article] Fibrinogen alpha C chain 5.9 kDa fragment (FIC5.9), a biomarker for various pathological conditions, is produced in post-blood collection by fibrinolysis and coagulation factors2016
- Author(s)
  Kikuchi W, Nishimura M, Kuga T, Tsuchida S, Saito T, Satoh M, Noda K, Kodera Y, Tomonaga T, Nomura F
- Journal Title
  
  Clinical Proteomics
  
  Volume: 13 Issue: 1 Pages: 27-27
- DOI
  10.1186/s12014-016-9129-6
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-26460081, KAKENHI-PROJECT-26460505, KAKENHI-PROJECT-26640115, KAKENHI-PROJECT-15K08610, KAKENHI-PROJECT-15K08611, KAKENHI-PROJECT-15K11379
[Journal Article] Expression of Wilms’ tumor 1 (WT1) in ameloblastomas2016
- Author(s)
  Bologna-Molina R, Takeda Y, Kuga T, Chosa N, Kitagawa M, Takata T, Ishisaki A, Mikami T
- Journal Title
  
  Journal of Oral Science
  
  Volume: 58 Issue: 3 Pages: 407-413
- DOI
  10.2334/josnusd.15-0546
- NAID
  130005266252
- ISSN
  1343-4934, 1880-4926
- Language
  English
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26460081, KAKENHI-PROJECT-16K11654
[Journal Article] v-Src Causes Chromosome Bridges in a Caffeine-Sensitive Manner by Generating DNA Damage2016
- Author(s)
  Masayoshi Ikeuchi, Yasunori Fukumoto, Takuya Honda, Takahisa Kuga, Youhei Saito, Naoto Yamaguchi and Yuji Nakayama
- Journal Title
  
  International Journal of Molecular Sciences
  
  Volume: 17(6) Issue: 6 Pages: 871-871
- DOI
  10.3390/ijms17060871
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-16J04141, KAKENHI-PROJECT-26460081, KAKENHI-PROJECT-15K07920, KAKENHI-PROJECT-15K07922
[Journal Article] FAM83H and casein kinase I regulate the organization of the keratin cytoskeleton and formation of desmosomes2016
- Author(s)
  Kuga T, Sasaki M, Mikami T, Miake Y, Adachi J, Shimizu M, Saito Y, Koura M, Takeda Y, Matsuda J, Tomonaga T, Nakayama Y
- Journal Title
  
  Scientific Reports
  
  Volume: 6 Issue: 1 Pages: 26557-26557
- DOI
  10.1038/srep26557
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-26460081
[Journal Article] ERK plays a role in chromosome alignment and participates in M-phase progression.2016
- Author(s)
  Iwamoto E, Ueta N, Matsui Y, Kamijo K, Kuga T, Saito Y, Yamaguchi N, Nakayama Y.
- Journal Title
  
  J. Cell. Biochem.
  
  Volume: 117 Issue: 6 Pages: 1340-1351
- DOI
  10.1002/jcb.25424
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-25460076, KAKENHI-PROJECT-26460081, KAKENHI-PROJECT-15K07922
[Journal Article] Yeast two-hybrid and one-hybrid screenings identify regulators of hsp70 gene expression2016
- Author(s)
  Saito Y, Nakagawa T, Kakihana A, Nakamura Y, Nabika T, Kasai M, Takamori M, Yamagishi N, Kuga T, Hatayama T, Nakayama Y.
- Journal Title
  
  Journal of Cellular Biochemistry.
  
  Volume: in press Issue: 9 Pages: 2109-2117
- DOI
  10.1002/jcb.25517
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-26870701, KAKENHI-PROJECT-26460081
[Journal Article] c-Abl-mediated tyrosine phosphorylation of JunB is required for Adriamycin-induced expression of p21.2015
- Author(s)
  Noritaka Yamaguchi, Ryuzaburo Yuki, Sho Kubota, Kazumasa Aoyama, Takahisa Kuga, Yuuki Hashimoto, Takeshi Tomonaga, and Naoto Yamaguchi.
- Journal Title
  
  Biochemical Journal
  
  Volume: 471 Issue: 1 Pages: 67-77
- DOI
  10.1042/bj20150372
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-15K07922, KAKENHI-PROJECT-26460081, KAKENHI-PROJECT-15K19545, KAKENHI-PROJECT-26893036, KAKENHI-PROJECT-14J04367, KAKENHI-PROJECT-25460356, KAKENHI-PROJECT-26670614, KAKENHI-PROJECT-25290054
[Journal Article] Role for Tyrosine Phosphorylation of A-kinase Anchoring Protein 8 (AKAP8) in its Dissociation from Chromatin and the Nuclear Matrix2015
- Author(s)
  Kubota S, Morii M, Yuki R, Yamaguchi N, Yamaguchi H, Aoyama K, Kuga T, Tomonaga T, Yamaguchi N.
- Journal Title
  
  J Biol Chem
  
  Volume: 290 Issue: 17 Pages: 10891-904
- DOI
  10.1074/jbc.m115.643882
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-26893036, KAKENHI-PROJECT-15K07922, KAKENHI-PROJECT-26460081, KAKENHI-PROJECT-15K19545, KAKENHI-PROJECT-14J04367, KAKENHI-PROJECT-26670614, KAKENHI-PROJECT-25290054
[Journal Article] Nuclear accumulation of annexin A2 contributes to chromosomal instability by coilin-mediated centromere damage2015
- Author(s)
  Kazami, T., Nie, H., Satoh, M., Kuga, T., Matsushita, K., Kawasaki, N., Tomonaga, T*., and Nomura, F
- Journal Title
  
  Oncogene
  
  Volume: in press Issue: 32 Pages: 4177-4189
- DOI
  10.1038/onc.2014.345
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-25290054, KAKENHI-PROJECT-26460505, KAKENHI-PROJECT-15K08610, KAKENHI-PROJECT-26460081, KAKENHI-PROJECT-26670614
[Journal Article] c-Abl induces stabilization of histone deacetylase 1 (HDAC1) in a kinase activity-dependent manner.2015
- Author(s)
  Kazumasa Aoyama, Noritaka Yamaguchi, Ryuzaboro Yuki, Mariko Morii, Sho Kubota, Kensuke Hirata, Kohei Abe, Takuya Honda, Takahisa Kuga, Yuuki Hashimoto, Takeshi Tomonaga, and Naoto Yamaguchi
- Journal Title
  
  Cell Biology International
  
  Volume: 39 Issue: 4 Pages: 446-456
- DOI
  10.1002/cbin.10413
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-25460356, KAKENHI-PROJECT-26893036, KAKENHI-PROJECT-15K07922, KAKENHI-PROJECT-26460081, KAKENHI-PROJECT-26670614, KAKENHI-PROJECT-25290054
[Journal Article] Increased expression of sorcin is associated with multidrug resistance in leukemia cells via up-regulation of MDR1 expression through cAMP response element-binding protein2014
- Author(s)
  Yamagishi N, Nakaoka R, Kondo R, Nishituji M, Saito Y, Kuga T, Hatayama T, Nakayama Y
- Journal Title
  
  Biochemical and Biophysical Research Communications
  
  Volume: 448 Issue: 4 Pages: 430-436
- DOI
  10.1016/j.bbrc.2014.04.125
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-26460081
[Journal Article] Increased expression of sorcin is associated with multidrug resistance in leukemia cells via up-regulation of MDR1 expression through cAMP response element-binding protein2014
- Author(s)
  Yamagishi N., Nakao R., Kondo R., Nishitsuji M., Saito Y., Kuga T., Hatayama T., and Nakayama Y
- Journal Title
  
  Biochem Biophys Res Commun
  
  Volume: 13 Pages: 430-436
- Data Source
  KAKENHI-PROJECT-24790184
[Journal Article] Genistein induces cytokinesis failure through RhoA delocalization and anaphase chromosome bridging2014
- Author(s)
  Nakayama Y., Saito Y., Soeda S., Iwamoto E., Ogawa S., Yamagishi N., Kuga T., and Yamaguchi N
- Journal Title
  
  J Cell Biochem
  
  Volume: 115 Pages: 763-771
- Data Source
  KAKENHI-PROJECT-24790184
[Journal Article] Genistein induces cytokinesis failure through RhoA delocalization and anaphase chromosome bridging.2014
- Author(s)
  Nakayama Y, Saito Y, Soeda S, Iwamoto E, Ogawa S, Yamagishi N, Kuga T, Yamaguchi N
- Journal Title
  
  J Cell Biochem.
  
  Volume: 115 Issue: 4 Pages: 763-771
- DOI
  10.1002/jcb.24720
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23590094, KAKENHI-PROJECT-24790184, KAKENHI-PROJECT-25460076, KAKENHI-PROJECT-26460081
[Journal Article] Discovery of colorectal cancer biomarker candidates by membrane proteomic analysisand subsequent verification using selected reaction monitoring and tissue microarrayanalysis2014
- Author(s)
  Kume H, Muraoka S, Kuga T, Adachi J, Narumi R, Watanabe S, Kuwano M, Kodera Y, Matsushita K, Fukuoka J, Masuda T, Ishihama Y, Matsubara H, Nomura F, Tomonaga T.
- Journal Title
  
  Mol Cell Proteomics.
  
  Volume: M113 Issue: 6 Pages: 37093-37093
- DOI
  10.1074/mcp.m113.037093
- Peer Reviewed
- Data Source
  KAKENHI-PUBLICLY-24116513, KAKENHI-PROJECT-24241062, KAKENHI-PROJECT-24659017, KAKENHI-PROJECT-24659622, KAKENHI-PROJECT-24790184, KAKENHI-PROJECT-25290054, KAKENHI-PROJECT-25460715, KAKENHI-PROJECT-26460081, KAKENHI-PROJECT-26640115, KAKENHI-PROJECT-26670614
[Journal Article] Nmi interacts with Hsp105beta and enhances the Hsp105beta-mediated Hsp70 expression2014
- Author(s)
  Saito Y, Yukawa A, Matozaki M, Mikami H, Yamagami T, Kuga T, Yamagishi N, Hatayama T, Nakayama Y
- Journal Title
  
  Experimental Cell Research
  
  Volume: 327 Issue: 1 Pages: 163-170
- DOI
  10.1016/j.yexcr.2014.07.023
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-26460081, KAKENHI-PROJECT-26870701
[Journal Article] Lamin B2 prevents chromosome instability by ensuring proper mitotic chromosome segregation2014
- Author(s)
  Kuga T., Nie H., Kazami T., Satoh M., Matsushita K., Nomura F., Maeshima K., Nakayama Y., and Tomonaga T
- Journal Title
  
  Oncogenesis
  
  Volume: 3
- Data Source
  KAKENHI-PROJECT-24790184
[Journal Article] Identification of Missing Proteins in the neXtProt Database and Unregistered Phosphopeptides in the PhosphoSitePlus Database As Part of the Chromosome-Centric Human Proteome Project.2013
- Author(s)
  Takashi Shiromizu
- Journal Title
  
  Journal of Proteome Research
  
  Volume: 印刷中 Issue: 6 Pages: 2414-2421
- DOI
  10.1021/pr300825v
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23701093, KAKENHI-PROJECT-24790184
[Journal Article] Lamin B2 prevents chromosome instability by ensuring proper mitotic chromosome segregation2013
- Author(s)
  Kuga, T., Nie, H., Kazami, T., Satoh, M., Matsushita, K., Nomura, F., Maeshima, K., Nakayama, Y., Tomonaga, T.
- Journal Title
  
  Oncogenesis
  
  Volume: 3 Issue: 3 Pages: e94-e94
- DOI
  10.1038/oncsis.2014.6
- Peer Reviewed
- Data Source
  KAKENHI-PLANNED-23115005, KAKENHI-PROJECT-23370078, KAKENHI-PROJECT-24659622, KAKENHI-PROJECT-24790184, KAKENHI-PROJECT-25290054, KAKENHI-PROJECT-26460081
[Journal Article] Phosphorylation of KRAB-associated Protein 1 (KAP1) at Tyr-449, Tyr-458, and Tyr-517 by Nuclear Tyrosine Kinases Inhibits the Association of KAP1 and Heterochromatin Protein 1alpha (HP1alpha) with Heterochromatin2013
- Author(s)
  Kubota S., Fukumoto Y., Aoyama K., Ishibashi K., Yuki R., Morinaga T., Honda T., Yamaguchi N., Hashimoto Y., Kuga T., Tomonaga T., and Yamaguchi N.
- Journal Title
  
  J Biol Chem
  
  Volume: 288 Pages: 17871-17883
- Data Source
  KAKENHI-PROJECT-24790184
[Journal Article] Formation of long and winding nuclear F-actin bundles by nuclear c-Abl tyrosine kinase.2013
- Author(s)
  Aoyama K., Yuki R., Horiike Y., Kubota S., Yamaguchi N., Morii M., Ishibashi K., Nakayama Y., Kuga T., Hashimoto Y., Tomonaga T, and Yamaguchi N.
- Journal Title
  
  Exp Cell Res
  
  Volume: 319 Issue: 20 Pages: 3251-68
- DOI
  10.1016/j.yexcr.2013.09.003
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24659622, KAKENHI-PROJECT-24790184, KAKENHI-PROJECT-25290054, KAKENHI-PROJECT-25460356
[Journal Article] Identification of Missing Proteins in the neXtProt Database and Unregistered Phosphopeptides in the PhosphoSitePlus Database As Part of the Chromosome-Centric Human Proteome Project2013
- Author(s)
  Shiromizu T., Adachi J., Watanabe S., Murakami T., Kuga T., Muraoka S., and Tomonaga T
- Journal Title
  
  J Proteome Res
  
  Volume: 12 Pages: 2414-2421
- Data Source
  KAKENHI-PROJECT-24790184
[Journal Article] Formation of long and winding nuclear F-actin bundles by nuclear c-Abl tyrosine kinase2013
- Author(s)
  Aoyama K., Yuki R., Horiike Y., Kubota S., Yamaguchi N., Morii M., Ishibashi K., Nakayama Y., Kuga T., Hashimoto Y., Tomonaga T., and Yamaguchi N.
- Journal Title
  
  Exp Cell Res
  
  Volume: 319 Pages: 3251-3268
- Data Source
  KAKENHI-PROJECT-24790184
[Journal Article] Serum fibrinogen alpha C-chain 5.9 kDa fragment (FIC 5.9) as a biomarker for early detection of hepatic fibrosis related to hepatitis C virus2013
- Author(s)
  Sogawa K, Noda K, Umemura H, Seimiya M, Kuga T, Tomonaga T, Nishimura M, Kanai F, Imazeki F, Takizawa H, Yoneda M, Nakajima A, Tsutsumi M, Yokosuka O, Nomura F
- Journal Title
  
  Proteomics Clin Appl
  
  Volume: (in press) Issue: 5-6 Pages: 424-431
- DOI
  10.1002/prca.201200094
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22590518, KAKENHI-PROJECT-24790184, KAKENHI-PROJECT-24790548
[Journal Article] A novel mechanism of keratin cytoskeleton organization through casein kinase I alpha and FAM83H in colorectal cancer.2013
- Author(s)
  Kuga, T., Kume, H., Kawasaki, N., Sato, M., Adachi, J., Shiromizu, T., Hoshino, I., Nishimori, T., Matsubara, H., and Tomonaga T.
- Journal Title
  
  J Cell Sci
  
  Volume: 126 Pages: 4721-31
- DOI
  10.1242/jcs.129684
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24659622, KAKENHI-PROJECT-24681009, KAKENHI-PROJECT-24790184, KAKENHI-PROJECT-25290054, KAKENHI-PROJECT-25460715, KAKENHI-PROJECT-25871241
[Journal Article] Serum fibrinogen alpha C-chain 5.9 kDa fragment as a biomarker for early detection of hepatic fibrosis related to hepatitis C virus2013
- Author(s)
  Sogawa K., Noda K., Umemura H., Seimiya M., Kuga T., Tomonaga T., Nishimura M., Kanai F., Imazeki F., Takizawa H., Yoneda M., Nakajima A., Tsutsumi M., Yokosuka O., and Nomura F.
- Journal Title
  
  Proteomics Clin Appl
  
  Volume: 7 Pages: 424-431
- Data Source
  KAKENHI-PROJECT-24790184
[Journal Article] Phosphorylation of KRAB-associated Protein 1 (KAP1) at Tyr-449, Tyr-458, and Tyr-517 by Nuclear Tyrosine Kinases Inhibits the Association of KAP1 and Heterochromatin Protein 1alpha (HP1alpha) with Heterochromatin.2013
- Author(s)
  Kubota, S., Fukumoto, Y., Aoyama, K., Ishibashi, K., Yuki, R., Morinaga, T., Honda, T., Yamaguchi, N., Hashimoto, Y., Kuga, T., Tomonaga T, and Yamaguchi, N.
- Journal Title
  
  J Biol Chem
  
  Volume: 288, Issue: 24 Pages: 17871-17883
- DOI
  10.1074/jbc.m112.437756
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24659622, KAKENHI-PROJECT-24790067, KAKENHI-PROJECT-24790184, KAKENHI-PROJECT-25290054, KAKENHI-PROJECT-25460356
[Journal Article] A novel mechanism of keratin cytoskeleton organization through casein kinase I alpha and FAM83H in colorectal cancer2013
- Author(s)
  Kuga T., Kume H., Kawasaki N., Sato M., Adachi J., Shiromizu T., Hoshino I., Nishimori T., Matsubara H., and Tomonaga T
- Journal Title
  
  J Cell Sci
  
  Volume: 126 Pages: 4721-4731
- Data Source
  KAKENHI-PROJECT-24790184
[Journal Article] A strategy for large-scale phosphoproteomics and SRM-based validation of human breast cancer tissue samples2012
- Author(s)
  Narumi R., Murakami T., Kuga T., Adachi J., Shiromizu T., Muraoka S., Kume H., Kodera Y., Matsumoto M., Nakayama K., Miyamoto Y., Ishitobi M., Inaji H., Kato K., and Tomonaga T.
- Journal Title
  
  J Proteome Res
  
  Volume: 11 Pages: 5311-5322
- Data Source
  KAKENHI-PROJECT-24790184
[Journal Article] 問題飲酒者マーカー5.9kDaペプチドの発現機構における血液凝固系の関与2010
- Author(s)
  久家貴寿,曽川一幸,野田健太,梅村啓史,佐藤守,小寺義男,松下一之,朝長毅,野村文夫
- Journal Title
  
  アルコールと医学生物学
  
  Volume: 29 Pages: 89-92
- Data Source
  KAKENHI-PROJECT-22790539
[Journal Article] Phosphorylation statuses at different residues of lamin B2, B1, and A/C dynamically and independently change throughout the cell cycle.2010
- Author(s)
  Takahisa Kuga
- Journal Title
  
  Experimental Cell Research
  
  Volume: 316 Pages: 2301-2312
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22790539
[Journal Article] The Lyn kinase C-lobe mediates Golgi export of Lyn through conformation-dependent ACSL3 association2010
- Author(s)
  Obata Y, Fukumoto Y, Nakayama Y, Kuga T, Dohmae N, Yamaguchi N
- Journal Title
  
  J Cell Sci
  
  Volume: 123 Pages: 2649-2662
- Data Source
  KAKENHI-PROJECT-22790539
[Journal Article] Phosphorylation statuses at different residues of lamin B2, B1, and A/C dynamically and independently change throughout the cell cycle2010
- Author(s)
  Kuga T, Nozaki N, Matsushita K, Nomura F, Tomonaga T
- Journal Title
  
  Exp Cell Res
  
  Volume: 316 Pages: 2301-2312
- Data Source
  KAKENHI-PROJECT-22790539
[Patent] 大腸癌治療剤2013
- Inventor(s)
  朝長毅、久家貴寿、久米秀明
- Industrial Property Rights Holder
  独立行政法人医薬基盤研究所
- Industrial Property Rights Type
  特許
- Filing Date
  2013-06-11
- Overseas
- Data Source
  KAKENHI-PROJECT-24790184
[Patent] 大腸癌治療剤2013
- Inventor(s)
  朝長毅、久家貴寿、久米秀明
- Industrial Property Rights Holder
  独立行政法人医薬基盤研究所
- Industrial Property Rights Type
  特許
- Filing Date
  2013-06-11
- Data Source
  KAKENHI-PROJECT-24790184
[Patent] 大腸癌治療剤2012
- Inventor(s)
  朝長毅、久家貴寿、久米秀明
- Industrial Property Rights Holder
  独立行政法人医薬基盤研究所
- Industrial Property Rights Type
  特許
- Industrial Property Number
  2012-135619
- Filing Date
  2012-06-15
- Data Source
  KAKENHI-PROJECT-24790184
[Patent] 大腸癌治療剤2012
- Inventor(s)
  朝長毅、久家貴寿、久米秀明
- Industrial Property Rights Holder
  独立行政法人医薬基盤研究所
- Industrial Property Rights Type
  特許
- Industrial Property Number
  2012-135619
- Filing Date
  2012-06-15
- Data Source
  KAKENHI-PROJECT-24790184
[Presentation] 皮膚虚血再灌流障害マウスの創傷形成に対するフェロスタチンの影響2024
- Author(s)
  荒尾七海、津山陽佳、戸田暖乃、水野里菜、久家貴寿、北谷和之、西田健太朗
- Organizer
  日本薬学会第144年会
- Data Source
  KAKENHI-PROJECT-21K09865
[Presentation] 転移能が異なる結腸がんHCT116由来細胞の遊走・浸潤能の比較2022
- Author(s)
  河島出、久家貴寿、谷口将済、山岸伸行
- Organizer
  第72回日本薬学会関西支部大会
- Data Source
  KAKENHI-PROJECT-21K09865
[Presentation] v-Src によるサイクリン依存性キナーゼのリン酸化2019
- Author(s)
  鏡畑直也、堀内麻利安、久家貴寿、池内正剛、齊藤洋平、山口直人、中山祐治
- Organizer
  第69回日本薬学会関西支部総会・大会
- Data Source
  KAKENHI-PROJECT-17K08293
[Presentation] v-Srcにより誘導されるmitotic slippageは抗がん剤感受性を低下させる2019
- Author(s)
  萩野真理，堀内麻利安，久家貴寿，齊藤洋平，山口直人，中山祐治
- Organizer
  日本薬学会第139年会
- Data Source
  KAKENHI-PROJECT-16K08253
[Presentation] FAM83H 遺伝子改変マウスの表皮層ではケラチン骨格異常が生じる2019
- Author(s)
  山根優花、久家貴寿、黒橋哲也、谷口将済、佐々木光穂、鈴木治、松田潤一郎、山岸伸行
- Organizer
  第69回日本薬学会関西支部総会・大会
- Data Source
  KAKENHI-PROJECT-17K08293
[Presentation] v-Srcにより誘導されるmitotic slippageは抗がん剤感受性を低下させる2019
- Author(s)
  萩野真理、堀内麻利安、久家貴寿、齊藤洋平、山口直人、中山祐治
- Organizer
  日本薬学会第139年会
- Data Source
  KAKENHI-PROJECT-17K08293
[Presentation] がん細胞のパクリタキセル耐性をダサチニブが改善する仕組みの解明2019
- Author(s)
  吉見紗弥花、久家貴寿、谷口将済、山岸伸行
- Organizer
  第69回日本薬学会関西支部総会・大会
- Data Source
  KAKENHI-PROJECT-17K08293
[Presentation] ミッドゾーン制御機構の解明を目指した新規免疫蛍光染色法の構築2018
- Author(s)
  居藤亜弥，久家貴寿，海堀祐一郎，齊藤洋平，中山祐治
- Organizer
  日本薬学会第138年会
- Data Source
  KAKENHI-PROJECT-17K08293
[Presentation] v-SrcはCdk1リン酸化を介して抗がん剤感受性を低下させる2018
- Author(s)
  萩野真理，堀内麻利安，久家貴寿，齊藤洋平，山口直人，中山祐治
- Organizer
  第68回日本薬学会近畿支部総会・大会
- Data Source
  KAKENHI-PROJECT-16K08253
[Presentation] ミッドゾーン制御機構の解明を目指した新規免疫蛍光染色法の構築2018
- Author(s)
  居藤亜弥，久家貴寿，海堀祐一郎，齊藤洋平，中山祐治
- Organizer
  日本薬学会第138年会
- Data Source
  KAKENHI-PROJECT-16K08253
[Presentation] FAM83Hがケラチン骨格に局在化するために必要なアミノ酸領域の同定2018
- Author(s)
  染谷健介、久家貴寿、村髙紫野、井上直樹、谷口将済、山岸伸行
- Organizer
  第68回日本薬学会近畿支部総会・大会
- Data Source
  KAKENHI-PROJECT-17K08293
[Presentation] v-SrcはCdk1リン酸化を介して抗がん剤感受性を低下させる2018
- Author(s)
  萩野真理、堀内麻利安、久家貴寿、齊藤洋平、山口直人、中山祐治
- Organizer
  第68回日本薬学会近畿支部総会・大会
- Data Source
  KAKENHI-PROJECT-17K08293
[Presentation] Rab35が制御する輸送に対するv-Srcの影響2018
- Author(s)
  上拾石佐和，久家貴寿，齊藤洋平，山口直人，中山祐治
- Organizer
  日本薬学会第138年会
- Data Source
  KAKENHI-PROJECT-16K08253
[Presentation] Rab35が制御する輸送に対するv-Srcの影響2018
- Author(s)
  上拾石佐和，久家貴寿，齊藤洋平，山口直人，中山祐治
- Organizer
  日本薬学会第138年会
- Data Source
  KAKENHI-PROJECT-17K08293
[Presentation] Cdk1のリン酸化を介した，v-Srcによるmitotic slippageの誘導2018
- Author(s)
  堀内麻利安，久家貴寿，齊藤洋平，長野麻衣子，足立淳，朝長毅，山口直人，中山祐治
- Organizer
  第91回日本生化学会大会
- Data Source
  KAKENHI-PROJECT-16K08253
[Presentation] 受容体型チロシンキナーゼによる細胞分裂制御機構の解析2017
- Author(s)
  海堀祐一郎，久家貴寿，齊藤洋平，中山祐治
- Organizer
  日本薬学会第１３７年会
- Place of Presentation
  仙台
- Year and Date
  2017-03-25
- Data Source
  KAKENHI-PROJECT-16K08253
[Presentation] FAM83Hはケラチン細胞骨格を制御することでメナメル芽細胞の維持に働く2017
- Author(s)
  久家貴寿、佐々木光穂、鈴木治、中山祐治、朝長毅、山岸伸行
- Organizer
  第59回歯科基礎医学会学術大会
- Invited
- Data Source
  KAKENHI-PROJECT-17K08293
[Presentation] 熱ショックタンパク質Hsp105の分裂期チェックポイント制御機構の解明2017
- Author(s)
  柿花采那、大東優衣、齊藤洋平、久家貴寿、中山祐治
- Organizer
  2017年度生命科学系学会合同年次大会
- Data Source
  KAKENHI-PROJECT-16K08253
[Presentation] フラボノイド類による小胞体分子シャペロンGRP78 発現誘導性と伸長ポリグルタミン鎖含有タンパク質の凝集抑制効果の検討2017
- Author(s)
  出口桃子、西川奈央子、久家貴寿、山岸伸行
- Organizer
  第67回日本薬学会近畿支部総会・大会
- Data Source
  KAKENHI-PROJECT-17K08293
[Presentation] カルシウム結合タンパク質Sorcin による伸長ポリグルタミン鎖含有タンパク質の凝集抑制効果の検討2017
- Author(s)
  西脇祐貴、沢田成矢、永長遼一、久家貴寿、山岸伸行
- Organizer
  第67回日本薬学会近畿支部総会・大会
- Data Source
  KAKENHI-PROJECT-17K08293
[Presentation] Srcの異常な活性化が細胞分裂異常を誘導する新規機構の解明2017
- Author(s)
  堀内麻利安，久家貴寿，齊藤洋平，朝長毅，中山祐治
- Organizer
  日本薬学会第１３７年会
- Place of Presentation
  仙台
- Year and Date
  2017-03-25
- Data Source
  KAKENHI-PROJECT-16K08253
[Presentation] 細胞分裂後期，終期に形成されるスピンドルミッドゾーン特異的な新規染色方法2017
- Author(s)
  居藤亜弥、久家貴寿、海堀祐一郎、齊藤洋平、中山祐治
- Organizer
  2017年度生命科学系学会合同年次大会
- Data Source
  KAKENHI-PROJECT-16K08253
[Presentation] FAM83Hは新規のがん浸潤関連タンパク質である2017
- Author(s)
  久家貴寿、齊藤洋平、朝長毅、中山祐治
- Organizer
  日本薬学会第137年会
- Place of Presentation
  仙台
- Year and Date
  2017-03-24
- Data Source
  KAKENHI-PROJECT-26460081
[Presentation] Hsp105/110ファミリータンパク質の細胞分裂の進行への関与2017
- Author(s)
  手島皓子，岡本菜美子，柿花采那，齊藤洋平，久家貴寿，中山祐治
- Organizer
  日本薬学会第１３７年会
- Place of Presentation
  仙台
- Year and Date
  2017-03-25
- Data Source
  KAKENHI-PROJECT-16K08253
[Presentation] 細胞分裂後期特異的なタンパク質のチロシンリン酸化2016
- Author(s)
  北郷真由絵，岡田美咲，海堀祐一郎，久家貴寿，齊藤洋平，中山祐治
- Organizer
  第66回日本薬学会近畿支部総会・大会
- Place of Presentation
  大阪
- Year and Date
  2016-10-15
- Data Source
  KAKENHI-PROJECT-16K08253
[Presentation] v-Srcによる多極紡錘体の形成2016
- Author(s)
  抱恵子，池内正剛，本田拓也，久家貴寿，齊藤洋平，山口直人，中山祐治
- Organizer
  第３９回日本分子生物学会年会
- Place of Presentation
  横浜
- Year and Date
  2016-11-30
- Data Source
  KAKENHI-PROJECT-16K08253
[Presentation] FAM83H遺伝子変異に起因するエナメル質形成不全症の発症メカニズム研究2014
- Author(s)
  久家貴寿,朝長毅,齊藤洋平,三上俊成,武田泰典,中山祐治
- Organizer
  日本薬学会第134年会
- Place of Presentation
  熊本
- Data Source
  KAKENHI-PROJECT-24790184
[Presentation] A Kinase Activity-Estimating Method Using LC-MS/MS2013
- Author(s)
  Nagano M, Kuga T, Adachi J, Tomonaga T
- Organizer
  Human Proteome Organization (HUPO) 12th Annual World Congress
- Place of Presentation
  横浜
- Data Source
  KAKENHI-PROJECT-24790184
[Presentation] 大腸癌細胞におけるFAM83H と casein kinase Iαを介したケラチン骨格制御機構の解明2013
- Author(s)
  久家貴寿，久米秀明，川崎直子，足立淳，星野敢，松原久裕，齊藤洋平，中山祐治，朝長毅
- Organizer
  第36回日本分子生物学会
- Place of Presentation
  神戸
- Data Source
  KAKENHI-PROJECT-24790184
[Presentation] A Novel Mechanism of Keratin Cytoskeleton Organization Through Casein Kinase I Alpha and FAM83H in Colorectal Cancer : Interactome Analysis of FAM83H2013
- Author(s)
  Kuga T, Kume H, Kawasaki N, Sato M, Adachi J, Shiromizu T, Hoshino I, Matsubara H, Tomonaga T
- Organizer
  Human Proteome Organization (HUPO) 12^<th> Annual World Congress
- Place of Presentation
  Yokohama, Japan
- Data Source
  KAKENHI-PROJECT-24790184
[Presentation] annexin A2の核内蓄積はcoilin を介したセントロメア損傷によって染色体不安定性に関与する2013
- Author(s)
  風見隆浩，朝長毅，川崎直子，佐藤守，久家貴寿，松下一之，野村文夫
- Organizer
  第36回日本分子生物学会
- Place of Presentation
  神戸
- Data Source
  KAKENHI-PROJECT-24790184
[Presentation] A Novel Mechanism of Keratin Cytoskeleton Organization Through Casein Kinase I Alpha and FAM83H in Colorectal Cancer: Interactome Analysis of FAM83H2013
- Author(s)
  Kuga T, Kume H, Kawasaki N, Sato M, Adachi J, Shiromizu T, Hoshino I, Matsubara H, Tomonaga T
- Organizer
  Human Proteome Organization (HUPO) 12th Annual World Congress
- Place of Presentation
  横浜
- Data Source
  KAKENHI-PROJECT-24790184
[Presentation] Quantitative Phosphoproteome Analysis of Cultured Stomach Cancer Cell Lines Aimed at Development of Biomarkers for Prediction of Drug Efficacy2013
- Author(s)
  Hashiguchi K, Muraoka S, Adachi J, Sato M, Kuga T, Watanabe R, Shiromizu T, Hashimoto Y, Nagano M, Kishida M, Tomonaga T
- Organizer
  Human Proteome Organization (HUPO) 12th Annual World Congress
- Place of Presentation
  横浜
- Data Source
  KAKENHI-PROJECT-24790184
[Presentation] 大腸癌細胞におけるFAM83Hとcasein kinase Iαを介したケラチン骨格制御機構の解明2013
- Author(s)
  久家貴寿,久米秀明,川崎直子,足立淳,星野敢,松原久裕,齊藤洋平,中山祐治,朝長毅
- Organizer
  第36回日本分子生物学会
- Place of Presentation
  神戸
- Data Source
  KAKENHI-PROJECT-24790184
[Presentation] 新規大腸癌関連タンパク質の予後予測マーカー応用を目指した取り組み2012
- Author(s)
  久家貴寿
- Organizer
  第9回千葉疾患プロテオミクス研究会
- Place of Presentation
  東京
- Year and Date
  2012-11-24
- Data Source
  KAKENHI-PROJECT-24790184
[Presentation] オミックス技術を駆使した新規大腸癌関連タンパク質の同定2012
- Author(s)
  久家貴寿,久米秀明,足立淳,星野敢,松原久裕,朝長毅
- Organizer
  第71回日本癌学会学術総会
- Place of Presentation
  札幌
- Data Source
  KAKENHI-PROJECT-24790184
[Presentation] 大腸癌手術標本の発現解析とインタラクトーム解析による新規癌関連タンパク質の同定2012
- Author(s)
  久家貴寿,久米秀明,川崎直子,足立淳,星野敢,松原久裕,朝長毅
- Organizer
  日本プロテオーム学会2012年会
- Place of Presentation
  東京
- Data Source
  KAKENHI-PROJECT-24790184
[Presentation] Phosphoproteomic analysis of human colorectal cancer tissues for exploring a novel cancer metastatic biomarker2011
- Author(s)
  白水崇,鳴海良平,久家貴寿,足立淳,松原久裕,松本雅紀,中山敬一,朝長毅
- Organizer
  第70回日本癌学会学術総会
- Place of Presentation
  愛知
- Data Source
  KAKENHI-PROJECT-22790539
[Presentation] 大腸がん手術組織標本の定量的リン酸化プロテオーム解析2011
- Author(s)
  久家貴寿,鳴海良平,村上達夫,足立淳,白水崇,小寺義男,松原久裕,松本雅記,中山敬一,朝長毅
- Organizer
  日本プロテオーム学会2011年会
- Place of Presentation
  新潟
- Data Source
  KAKENHI-PROJECT-22790539
[Presentation] Phosphoproteomic analysis of clinical colon cancer specimen ; Exploring a novel factor of cancer metastasis2011
- Author(s)
  T. Shiromizu, R. Narumi, T. Kuga, J. Adachi, H. Matsubara, M. Matsumoto, K. Nakayama, T. Tomonaga
- Organizer
  HUPO 2011
- Place of Presentation
  Geneva, Swiss
- Data Source
  KAKENHI-PROJECT-22790539
[Presentation] SRM/MRM法を用いたリン酸化ペプチドの定量法の確立2011
- Author(s)
  村上達夫、鳴海良平、久家貴寿、石飛真人、稲治英生、宮本泰豪、加藤菊也、小寺義男、朝長毅
- Organizer
  第34回日本分子生物学会年会
- Place of Presentation
  横浜
- Data Source
  KAKENHI-PROJECT-22790539
[Presentation] ヒト大腸癌臨床検体を用いたリン酸化プロテオーム解析による新規転移因子の探索2011
- Author(s)
  白水崇,鳴海良平,久家貴寿,足立淳,松原久裕,松本雅紀,中山敬一,朝長毅
- Organizer
  第9回日本プロテオーム学会
- Place of Presentation
  新潟
- Data Source
  KAKENHI-PROJECT-22790539
[Presentation] 大腸癌の定量的リン酸化プロテオーム解析2011
- Author(s)
  久家貴寿,足立淳,白水崇,松原久裕,中山敬一,小寺義男,朝長毅
- Organizer
  第70回日本癌学会学術総会
- Place of Presentation
  名古屋
- Data Source
  KAKENHI-PROJECT-22790539
[Presentation] Global phosphorylation and ubiquitination dynamics in DNA-damage response network2011
- Author(s)
  J. Adachi, R. Narumi, S. Sano, T. Kuga, T. Shiromizu, M. Matsumoto, K. Nakayama, M. Ikura, T. Ikura, M. Takata, T. Tomonaga
- Organizer
  HUPO2011
- Place of Presentation
  Geneva, Switzerland
- Data Source
  KAKENHI-PROJECT-22790539
[Presentation] DNA損傷応答におけるリン酸化・ユビキチン化プロテオーム定量解析2011
- Author(s)
  足立淳、鳴海良平、佐野聖三、久家貴寿、白水崇、松本雅記、中山敬一、井倉正枝、井倉毅、高田穣、朝長毅
- Organizer
  日本プロテオーム学会2011年会
- Place of Presentation
  新潟
- Data Source
  KAKENHI-PROJECT-22790539
[Presentation] 大規模リン酸化プロテオーム解析による癌転移に関わる新規リン酸化シグナルの探索2011
- Author(s)
  白水崇,鳴海良平,久家貴寿,足立淳,松原久裕,松本雅紀,中山敬一,朝長毅
- Organizer
  第63回日本細胞生物学会大会
- Place of Presentation
  北海道
- Data Source
  KAKENHI-PROJECT-22790539
[Presentation] リン酸化プロテオミクスを用いた新規DNA損傷初期応答キナーゼの探索2011
- Author(s)
  足立淳、鳴海良平、佐野聖三、久家貴寿、白水崇、松本雅記、中山敬一、井倉正枝、井倉毅、高田穣、朝長毅
- Organizer
  第34回日本分子生物学会年会
- Place of Presentation
  横浜
- Data Source
  KAKENHI-PROJECT-22790539
[Presentation] Global phosphorylation and ubiquitination dynamics in DNA-damage response network2011
- Author(s)
  足立淳、久家貴寿、白水崇、中山敬一、井倉毅、高田穣、朝長毅
- Organizer
  第70回日本癌学会学術総会
- Place of Presentation
  名古屋
- Data Source
  KAKENHI-PROJECT-22790539
[Presentation] 定量的リン酸化プロテオミクスとバイオインフォマティクスを用いた大腸がんリン酸化シグナル伝達機構の包括的理解2011
- Author(s)
  久家貴寿,足立淳,白水崇,村上達夫,松原久裕,松本雅記,中山敬一,福岡順也,朝長毅
- Organizer
  第34回日本分子生物学会年会
- Place of Presentation
  横浜
- Data Source
  KAKENHI-PROJECT-22790539
[Presentation] リン酸化プロテオーム解析による大腸癌バイオマーカー探索と検証2010
- Author(s)
  久家貴寿
- Organizer
  第7回千葉疾患プロテオミクス研究会
- Place of Presentation
  日東紡績八重洲ビル(東京)
- Year and Date
  2010-11-13
- Data Source
  KAKENHI-PROJECT-22790539
[Presentation] 大腸癌臨床検体を用いた定量的大規模リン酸化プロテオーム解析2010
- Author(s)
  久家貴寿、鳴海良平、松本雅記、中山敬一、松原久裕、松下一之、野村文夫、朝長毅
- Organizer
  日本ヒトプロテオーム機構第8回大会
- Place of Presentation
  千葉
- Data Source
  KAKENHI-PROJECT-22790539
[Presentation] DNA損傷応答ネットワークにおけるリン酸化・ユビキチン化修飾ダイナミクスのプロテオーム解析2010
- Author(s)
  足立淳、鳴海良平、佐野聖三、久家貴寿、白水崇、松本雅記、中山敬一、茂木章、井倉毅、高田穣、朝長毅
- Organizer
  第33回日本分子生物学会年会・第83回日本生化学会大会合同大会
- Place of Presentation
  神戸
- Data Source
  KAKENHI-PROJECT-22790539
[Presentation] 大腸癌の大規模リン酸化プロテオーム解析2010
- Author(s)
  久家貴寿、松下一之、野村文夫、松原久裕、中山敬一、朝長毅
- Organizer
  第69回日本癌学会学術総会
- Place of Presentation
  大阪
- Data Source
  KAKENHI-PROJECT-22790539
[Presentation] 大腸癌臨床検体を用いた定量的大規模リン酸化プロテオーム解析2010
- Author(s)
  久家貴寿
- Organizer
  日本ヒトプロテオーム機構第8回大会
- Place of Presentation
  東京ベイホテル東急(千葉)
- Year and Date
  2010-07-27
- Data Source
  KAKENHI-PROJECT-22790539
[Presentation] 大腸癌の大規模リン酸化プロテオーム解析2010
- Author(s)
  久家貴寿
- Organizer
  第69回日本癌学会学術総会
- Place of Presentation
  大阪国際会議場(大阪)
- Year and Date
  2010-09-24
- Data Source
  KAKENHI-PROJECT-22790539
[Presentation] 定量的リン酸化プロテオミクスによる乳癌組織の予後不良群と予後良好群の比較2010
- Author(s)
  鳴海良平、久家貴寿、松本雅記、中山敬一、石飛真人、稲治英生、宮本泰豪、加藤菊也、朝長毅
- Organizer
  第33回日本分子生物学会年会・第83回日本生化学会大会合同大会
- Place of Presentation
  神戸
- Data Source
  KAKENHI-PROJECT-22790539
[Presentation] 大腸癌細胞の細胞核のプロテオーム解析による染色体不安定性に関連するタンパク質の探索2010
- Author(s)
  越中屋里香、久家貴寿、久米秀明、鳴海良平、足立淳、朝長毅
- Organizer
  第33回日本分子生物学会年会・第83回日本生化学会大会合同大会
- Place of Presentation
  神戸
- Data Source
  KAKENHI-PROJECT-22790539
[Presentation] 定量的リン酸化プロテオミクスによる乳癌の予後不良群と予後良好群の比較2010
- Author(s)
  鳴海良平、久家貴寿、松本雅記、中山敬一、石飛真人、稲治英生、宮本泰豪、加藤菊也、朝長毅
- Organizer
  日本ヒトプロテオーム機構第8回大会
- Place of Presentation
  千葉
- Data Source
  KAKENHI-PROJECT-22790539
[Presentation] リン酸化プロテオーム解析による大腸癌バイオマーカー探索と検証2010
- Author(s)
  久家貴寿
- Organizer
  第7回千葉疾患プロテオミクス研究会
- Place of Presentation
  東京
- Year and Date
  2010-11-13
- Data Source
  KAKENHI-PROJECT-22790539
[Presentation] 細胞核のプロテオーム解析による染色体不安定性関連タンパク質の探索2010
- Author(s)
  越中屋里香、久家貴寿、久米秀明、鳴海良平、足立淳、朝長毅
- Organizer
  日本ヒトプロテオーム機構第8回大会
- Place of Presentation
  千葉
- Data Source
  KAKENHI-PROJECT-22790539
[Presentation] 大規模リン酸化プロテオーム解析による大腸癌バイオマーカー探索2010
- Author(s)
  久家貴寿、鳴海良平、村岡賢、足立淳、松本雅記、中山敬一、松原久裕、松下一之、野村文夫、長野一也、角田慎一、朝長毅
- Organizer
  第33回日本分子生物学会年会・第83回日本生化学会大会合同大会
- Place of Presentation
  神戸
- Data Source
  KAKENHI-PROJECT-22790539
[Presentation] 大規模リン酸化プロテオーム解析による大腸癌バイオマーカー探索2010
- Author(s)
  久家貴寿
- Organizer
  第33回日本分子生物学会年会・第83回日本生化学会大会合同大会
- Place of Presentation
  神戸ポートアイランド(神戸)
- Year and Date
  2010-12-10
- Data Source
  KAKENHI-PROJECT-22790539
[Presentation] FAM83H regulates organization of the keratin cytoskeleton in colorectal cancer cells
- Author(s)
  Kuga T, Saito, Y, Yamagishi N, Tomonaga T, Nakayama Y
- Organizer
  The 2014 ASCB meeting
- Place of Presentation
  Phirladelphia
- Year and Date
  2014-12-06 – 2014-12-10
- Data Source
  KAKENHI-PROJECT-26460081
[Presentation] インタラクトーム解析を用いた疾患関連タンパク質FAM83Hの解析
- Author(s)
  久家貴寿、朝長毅、中山祐治
- Organizer
  日本薬学会第135年会
- Place of Presentation
  神戸
- Year and Date
  2015-03-25 – 2015-03-28
- Invited
- Data Source
  KAKENHI-PROJECT-26460081

1. TOMONAGA Takeshi (80227644)

# of Collaborated Projects: 3 results

# of Collaborated Products: 32 results
2. 山岸伸行 (60298685)

# of Collaborated Projects: 3 results

# of Collaborated Products: 10 results
3. Nakayama Yuji (10280918)

# of Collaborated Projects: 2 results

# of Collaborated Products: 23 results
4. 齊藤洋平 (90411032)

# of Collaborated Projects: 2 results

# of Collaborated Products: 25 results
5. 佐々木光穂 (20432536)

# of Collaborated Projects: 2 results

# of Collaborated Products: 3 results
6. YAMAGUCHI Noritaka

# of Collaborated Projects: 0 results

# of Collaborated Products: 3 results
7. MIZUTANI Yasuyoshi

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
8. SEIMIYA Masanori

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
9. ISHIHAMA YASUSHI

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
10. 幸龍三郎

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
11. 白水崇

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
12. 前島一博

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
13. 山口直人

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
14. 青山和正

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
15. 鈴木元

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
16. 村手隆

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
17. 野村文夫

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Kuga Takahisa 久家 貴寿

KUGA Takahisa 久家 貴寿

Research Projects

Research Products

Co-Researchers

FAM83H変異体の細胞内異所局在化とエナメル質形成不全症との因果関係解明研究Principal Investigator

Principal Investigator

Project Period (FY)

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FAM83H変異タンパク質のリンカー機能破綻とエナメル質形成不全症との関係性Principal Investigator

Principal Investigator

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Review Section

Research Institution

Analysis of FAM83H gene-modified mice to reveal the mechanism of amelogenesis imperfectPrincipal Investigator

Principal Investigator

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Research Institution

Regulation of cell division by tyrosine phosphorylation signaling

Principal Investigator

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Analysis of the mechanism by which mutations of the FAM83H gene cause amelogenesis imperfectaPrincipal Investigator

Principal Investigator

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Research Institution

Discovery of protein phosphorylation markers to predict the efficacy of anti-EGFR antibody drugs in colorectal cancer patientsPrincipal Investigator

Principal Investigator

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Discovery of biomarkers for early colon cancer using a phospho-proteomic approachPrincipal Investigator

Principal Investigator

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Research Institution

[Journal Article] Phosphotyrosine proteomics in cells synchronized at monopolar cytokinesis reveals EphA2 as functioning in cytokinesis2023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] The conserved C-terminal residues of FAM83H are required for the recruitment of casein kinase 1 to the keratin cytoskeleton2022

Author(s)

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DOI

Data Source

[Journal Article] Cellular concentrations of plasmalogen species containing a polyunsaturated fatty acid significantly increase under hypoxia in human colorectal cancer, Caco2 cells2022

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DOI

Data Source

[Journal Article] Depletion of Csk preferentially reduces the protein level of LynA in a Cbl-dependent manner in cancer cells2020

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Data Source

[Journal Article] Desuppression of TGF-β signaling via nuclear c-Abl-mediated phosphorylation of TIF1γ/TRIM33 at Tyr-524, -610, and -1048.2019

Author(s)

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DOI

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[Journal Article] Hsp105α suppresses Adriamycin-induced cell death via nuclear localization signal-dependent nuclear accumulation2019

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DOI

Data Source

[Journal Article] Air-drying of cells enables visualization of antiparallel microtubule overlaps in the spindle midzone.2018

Author(s)

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DOI

Kuga Takahisa 久家貴寿

KUGA Takahisa 久家貴寿