KANAYA TAKASHI 金谷高史

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KANAYA Takashi 金谷高史

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Researcher Number	20553829
Other IDs
Affiliation (based on the past Project Information) *help	2021 – 2022: 国立研究開発法人理化学研究所, 生命医科学研究センター, 副チームリーダー 2018 – 2019: 国立研究開発法人理化学研究所, 生命医科学研究センター, 上級研究員 2014 – 2017: 国立研究開発法人理化学研究所, 統合生命医科学研究センター, 研究員 2013 – 2014: 独立行政法人理化学研究所, 統合生命医科学研究センター, 研究員 2012: 独立行政法人理化学研究所, 免疫系構築研究チーム, 研究員 2011: 独立行政法人理化学研究所, 免疫系構築研究チーム, 基礎科学特別研究員
Review Section/Research Field	Principal Investigator Immunology / Basic Section 38050:Food sciences-related / Basic Section 49070:Immunology-related / Biological Sciences Except Principal Investigator Immunology
Keywords	Principal Investigator M細胞 / 腸管免疫 / パイエル板 / FAE / 腸管上皮細胞 / 腸内細菌 / 食物繊維 / 樹状細胞 / IL-22 / IL-22BP … More / Spi-B / NF-kB / IgA / Salmonella typhimulium / TRAF6 / Peyer's patch / M cell / RelB / noncanonical NF-kB / 国際情報交流 / M 細胞 … More Except Principal Investigator Spi-B / RANKL / 免疫学 / M細胞 / 抗菌ペプチド / RANK / 遺伝子欠損マウス / NFkB / 濾胞関連上皮（FAE） / GALT / 細菌 / Ｍ細胞 / IL-22BP / 食物抗原 / IL-22 / NF-kB / 濾胞関連上皮 / 腸管関連リンパ組織 / 腸管免疫系 / 腸管免疫 / サルモネラ / GP2 / 分化 / NFκB / 細菌感染 / 腸内細菌 / シグナル伝達 / 上皮細胞 / 発生・分化 / 細胞・組織 / 粘膜免疫学 Less

食物繊維が小腸免疫系を発達させる仕組みの解明Principal Investigator
- Principal Investigator
  
  金谷高史
- Project Period (FY)
  2022 – 2025
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 38050:Food sciences-related
- Research Institution
  Institute of Physical and Chemical Research
The role of Peyer's patch dendritic cells and macropahges in regulation of mucosal immune responsesPrincipal Investigator
- Principal Investigator
  
  KANAYA TAKASHI
- Project Period (FY)
  2019 – 2021
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 49070:Immunology-related
- Research Institution
  Institute of Physical and Chemical Research
Differentiation and function of M cells, a unique intestinal epithelial cell subset for untigen uptake
- Principal Investigator
  
  Ohno Hiroshi
- Project Period (FY)
  2016 – 2018
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Immunology
- Research Institution
  Institute of Physical and Chemical Research
パイエル板濾胞随伴上皮（FAE）の機能制御を行う微小環境の解明Principal Investigator
- Principal Investigator
  
  金谷高史
- Project Period (FY)
  2015 – 2016
- Research Category
  
  Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
- Review Section
  
  Biological Sciences
- Research Institution
  Institute of Physical and Chemical Research
The role of NF-kB signaling in intestinal homeostasisPrincipal Investigator
- Principal Investigator
  
  Takashi Kanaya
- Project Period (FY)
  2014 – 2016
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Immunology
- Research Institution
  Institute of Physical and Chemical Research
Comprehensive understanding of a unique intestinal epithelial M cells specialized for luminal particulate antigen uptake
- Principal Investigator
  
  OHNO Hiroshi
- Project Period (FY)
  2012 – 2014
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Research Field
  
  Immunology
- Research Institution
  The Institute of Physical and Chemical Research
Evaluation of the effect of M-cell deficiency by using M-cell-deficient mouse model.Principal Investigator
- Principal Investigator
  
  KANAYA Takashi
- Project Period (FY)
  2011 – 2012
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Immunology
- Research Institution
  The Institute of Physical and Chemical Research

All 2019 2018 2017 2016 2013 2012 2011

All Journal Article Presentation Book

[Book] 実験医学増刊　生体バリア　粘膜や皮膚を舞台とした健康と疾患のダイナミクス2017
- Author(s)
  金谷高史、大野博司
- Total Pages
  227
- Publisher
  羊土社
- Data Source
  KAKENHI-PUBLICLY-15H01165
[Book] 実験医学増刊　生体バリア　粘膜や皮膚を舞台とした健康と疾患のダイナミクス2017
- Author(s)
  金谷高史、大野博司
- Total Pages
  5
- Publisher
  羊土社
- Data Source
  KAKENHI-PROJECT-26460584
[Book] 臨床免疫・アレルギー科2016
- Author(s)
  Kendle Maslowski、金谷高史、大野博司
- Total Pages
  7
- Publisher
  科学評論社
- Data Source
  KAKENHI-PROJECT-26460584
[Book] 臨床免疫・アレルギー科2016
- Author(s)
  Kendle Maslowski、金谷高史、大野博司
- Total Pages
  300
- Publisher
  科学評論社
- Data Source
  KAKENHI-PUBLICLY-15H01165
[Book] Intech Cytokeratins-Tools in Oncology2012
- Author(s)
  金谷高史、本堂哲也、宮澤光太郎、Michael T. Rose、麻生久
- Publisher
  ウシM細胞に関する研究
- Data Source
  KAKENHI-PROJECT-23790550
[Book] 実験医学増刊感染・共生・生体防御システム2012
- Author(s)
  金谷高史他
- Publisher
  羊土社
- Data Source
  KAKENHI-PROJECT-23790550
[Book] 実験医学増刊感染・共生・生体防御システム2012
- Author(s)
  金谷高史
- Total Pages
  7
- Publisher
  羊土社
- Data Source
  KAKENHI-PROJECT-23790550
[Book] The expression of cytokeratins in bovine intestinal microfold (M) cells. In: "Cytokeratins - Tools in Oncology" (Ed.: Hamilton G.)2012
- Author(s)
  Kanaya T, Hondo T, Miyazawa K, Rose M.T, Aso H
- Publisher
  InTech. Rijeka, Croatia
- Data Source
  KAKENHI-PROJECT-23790550
[Journal Article] Sox8 is essential for M cell maturation to accelerate IgA response at the early stage after weaning in mice2019
- Author(s)
  Kimura Shunsuke、Kobayashi Nobuhide、Nakamura Yutaka、Kanaya Takashi、Takahashi Daisuke、Fujiki Ryoji、Mutoh Mami、Obata Yuuki、Iwanaga Toshihiko、Nakagawa Tomoo、Kato Naoya、Sato Shintaro、Kaisho Tsuneyasu、Ohno Hiroshi、Hase Koji
- Journal Title
  
  The Journal of Experimental Medicine
  
  Volume: 216 Issue: 4 Pages: 831-846
- DOI
  10.1084/jem.20181604
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PUBLICLY-17H05799, KAKENHI-PROJECT-16H05207, KAKENHI-PROJECT-17H04088, KAKENHI-PROJECT-16J09413, KAKENHI-PROJECT-16K08457, KAKENHI-PROJECT-16K08836, KAKENHI-PROJECT-17K19568, KAKENHI-PROJECT-19K22532, KAKENHI-PUBLICLY-19H04813, KAKENHI-PROJECT-19H03702
[Journal Article] Development of intestinal M cells and follicle-associated epithelium is regulated by TRAF6-mediated NF-κB signaling.2018
- Author(s)
  Kanaya T, Sakakibara S, Jinnohara T, Hachisuka M, Tachibana N, Hidano S, Kobayashi T, Kimura S, Iwanaga T, Nakagawa T, Katsuno T, Kato N, Akiyama T, Sato T, Williams IR, Ohno H.
- Journal Title
  
  J Exp Med.
  
  Volume: 5;215(2) Issue: 2 Pages: 501-519
- DOI
  10.1084/jem.20160659
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K15680, KAKENHI-PUBLICLY-16H01631, KAKENHI-PLANNED-26115007, KAKENHI-PROJECT-17H06176, KAKENHI-PROJECT-16H05207, KAKENHI-PROJECT-17K08889, KAKENHI-PROJECT-17H04649, KAKENHI-PROJECT-16K08457, KAKENHI-PUBLICLY-18H04989, KAKENHI-PROJECT-17H04038
[Journal Article] IL-22BP dictates characteristics of Peyer's patch follicle-associated epithelium for antigen uptake.2017
- Author(s)
  Jinnohara T, Kanaya T, Hase K, Sakakibara S, Kato T, Tachibana N, Sasaki T, Hashimoto Y, Sato T, Watarai H, Kunisawa J, Shibata N, Williams I, Kiyono H, and Ohno H.
- Journal Title
  
  J. Exp. Med.
  
  Volume: 214 Issue: 6 Pages: 1607-1618
- DOI
  10.1084/jem.20160770
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17KT0055, KAKENHI-PLANNED-26115007, KAKENHI-PROJECT-17H01559, KAKENHI-PROJECT-16H05207, KAKENHI-PROJECT-17H04089, KAKENHI-PROJECT-16K14591, KAKENHI-PUBLICLY-16H01369
[Journal Article] IL-22BP dictates characteristics of Peyer’s patch follicle-associated epithelium for antigen uptake.2017
- Author(s)
  Toshi Jinnohara, Takashi Kanaya, Koji Hase, Sayuri Sakakibara, Tamotsu Kato, Naoko Tachibana, Takaharu Sasaki, Yusuke Hashimoto, Toshiro Sato, Hiroshi Watarai, Jun Kunisawa, Naoko Shibata, Ifor R Williams, Hiroshi Kiyono, and Hiroshi Ohno.
- Journal Title
  
  Journal of Experimental Medicine
  
  Volume: 印刷中
- Peer Reviewed / Acknowledgement Compliant / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26460584
[Journal Article] Uromodulin-SlpA binding dictates Lactobacillus acidophilus uptake by intestinal epithelial M cells.2017
- Author(s)
  Yanagihara S, Kanaya T, Fukuda S, Nakato G, Hanazato M, Wu XR, Yamamoto N, Ohno H.
- Journal Title
  
  Int. Immunol.
  
  Volume: 29 Issue: 8 Pages: 357-363
- DOI
  10.1093/intimm/dxx043
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16H05207
[Journal Article] IL-22BP dictates characteristics of Peyer’s patch follicle-associated epithelium for antigen uptake.2017
- Author(s)
  Toshi Jinnohara*, Takashi Kanaya*, Koji Hase, Sayuri Sakakibara, Tamotsu Kato, Naoko Tachibana, Takaharu Sasaki, Yusuke Hashimoto, Toshiro Sato, Hiroshi Watarai, Jun Kunisawa, Naoko Shibata, Ifor R Williams, Hiroshi Kiyono, and Hiroshi Ohno
- Journal Title
  
  Journal of Experimental Medicine
  
  Volume: 印刷中
- Peer Reviewed / Acknowledgement Compliant / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PUBLICLY-15H01165
[Journal Article] The functional maturation of M cells is dramatically reduced in the Peyer's patches of aged mice.2013
- Author(s)
  Kobayashi, A., Donaldson, D. S., Erridge, C., Kanaya, T., Williams, I. R., Ohno, H., Mahajan, A., Mabbott, N. A.
- Journal Title
  
  Mucosal Immunol.
  
  Volume: 6 Issue: 4 Pages: 1027-1037
- DOI
  10.1038/mi.2013.30
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24249029
[Journal Article] Identification of novel genes selectively expressed in the follicle-associated epithelium from the meta-analysis of transcriptomics data from multiple mouse cell and tissue populations.2012
- Author(s)
  Kobayashi A, Donaldson DS, Kanaya T, Fukuda S, Baillie JK, Freeman TC, Ohno H, Williams IR, Mabbott NA.
- Journal Title
  
  DNA Res.
  
  Volume: 19(5) Issue: 5 Pages: 407-22
- DOI
  10.1093/dnares/dss022
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23790550, KAKENHI-PROJECT-24249029, KAKENHI-PROJECT-24380072, KAKENHI-PROJECT-24658129, KAKENHI-PUBLICLY-24117524
[Journal Article] Epithelial cell-intrinsic notch signaling plays an essential role in the maintenance of gut immune homeostasis2012
- Author(s)
  Obata Y., et al
- Journal Title
  
  J.Immunol.
  
  Volume: 188 Issue: 5 Pages: 2427-2436
- DOI
  10.4049/jimmunol.1101128
- Peer Reviewed
- Data Source
  KAKENHI-PUBLICLY-22021046, KAKENHI-PROJECT-22689017, KAKENHI-PROJECT-23790550, KAKENHI-PLANNED-20113003
[Journal Article] M cell differentiation: distinct lineage or phenotypic transition? Salmonella provides answers.2012
- Author(s)
  Ohno H, Kanaya T, Williams IR.
- Journal Title
  
  Cell Host Microbe.
  
  Volume: 12(5) Issue: 5 Pages: 607-9
- DOI
  10.1016/j.chom.2012.11.003
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23790550
[Journal Article] The functional maturation of M cells is dramatically reduced in the Peyer's patches of aged mice.2012
- Author(s)
  Kobayashi Atsushi
- Journal Title
  
  Mucosal Immunol.
  
  Volume: 印刷中 Issue: 5 Pages: 1027-1037
- DOI
  10.1038/mi.2012.141
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23790550, KAKENHI-PROJECT-24249029
[Journal Article] The Ets transcription factor Spi-B is essential for the differentiation of intestinal microfold cells2012
- Author(s)
  Kanaya, T., Hase, K., Takahashi, D., Fukuda, S., Hoshino, K., Sasaki, I., Hemmi, H., Knoop, K. A., Kumar, N., Sato, M., Katsuno, T., Yokosuka, O., Toyooka, K., Nakai, K., Sakamoto, A., Kitahara, Y., Jinnohara, T., McSorley, S. J., Kaisho, T., Williams, I. R., and Ohno, H.
- Journal Title
  
  Nat Immunol
  
  Volume: 13 Issue: 8 Pages: 729-736
- DOI
  10.1038/ni.2352
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22590444, KAKENHI-PROJECT-22689017, KAKENHI-PROJECT-22770063, KAKENHI-PROJECT-23390124, KAKENHI-PROJECT-23659245, KAKENHI-PROJECT-23790550, KAKENHI-PROJECT-24249029, KAKENHI-PROJECT-24380072, KAKENHI-PROJECT-24658129, KAKENHI-PROJECT-24687007, KAKENHI-PLANNED-20113003, KAKENHI-PLANNED-21117003, KAKENHI-PUBLICLY-24117524, KAKENHI-PUBLICLY-24117723
[Journal Article] Orally administered prion protein is incorporated by in cells and propagated into lymphoid tissues by macrophages in prion protein knockout mice2011
- Author(s)
  Ikuro Takakura
- Journal Title
  
  American Journal of Pathology
  
  Volume: VOL.179 Issue: 3 Pages: 1301-1309
- DOI
  10.1016/j.ajpath.2011.05.058
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21380170, KAKENHI-PROJECT-23790550
[Presentation] 腸管免疫を発動するM細胞の分化機構に関する研究2018
- Author(s)
  金谷高史
- Organizer
  第47回日本免疫学会学術集会
- Data Source
  KAKENHI-PROJECT-16H05207
[Presentation] Lactobacillus acidophilus L-92株の小腸パイエル板の M細胞からの取り込みに関与する生体分子の探索2017
- Author(s)
  柳原沙恵, 金谷高史, 弘田辰彦, 山本直之, 大野博司
- Organizer
  第13回日本食品免疫学会学術大会
- Data Source
  KAKENHI-PROJECT-16H05207
[Presentation] Characteristics of M cells and follicle-associated epithelium2017
- Author(s)
  Ohno, H., Kanaya, T.
- Organizer
  第46回日本免疫学会学術集会
- Invited
- Data Source
  KAKENHI-PROJECT-16H05207
[Presentation] IL-22 binding protein (IL-22BP) regulates the properties of follicleassociated epithelium (FAE) to facilitate antigen uptake into Peyer's patches2017
- Author(s)
  Kanayak T., Jinnohara, T., Hase, K., Sasaki, T., Watarai, H., Shibata, N., Kuniswa, J., Kiyono, H., Ohno, H.
- Organizer
  第46回日本免疫学会学術集会
- Data Source
  KAKENHI-PROJECT-16H05207
[Presentation] 腸管M細胞におけるNF-κBの役割2016
- Author(s)
  金谷高史、榊原小百合、大野博司
- Organizer
  第68回細胞生物学会
- Place of Presentation
  京都府京都市京都テレサ
- Year and Date
  2016-06-15
- Data Source
  KAKENHI-PUBLICLY-15H01165
[Presentation] 腸管M細胞におけるNF-κBの役割2016
- Author(s)
  金谷高史、榊原小百合、大野博司
- Organizer
  第68回細胞生物学会
- Place of Presentation
  京都市
- Year and Date
  2016-06-15
- Data Source
  KAKENHI-PROJECT-26460584
[Presentation] Lactobacillus acidophilus L-92株の表層蛋白質が小腸パイエル板のM細胞からの取り込みに与える影響2016
- Author(s)
  柳原沙恵、福田真嗣、金谷高史、弘田辰彦、山本直之、大野博司
- Organizer
  日本乳酸菌学会2016年度大会
- Place of Presentation
  北里大学白金キャンパスコンベンションホール(東京都・港区）
- Year and Date
  2016-07-09
- Data Source
  KAKENHI-PROJECT-16H05207
[Presentation] The role of M cells in intestinal helminthic infection2013
- Author(s)
  Chikako Shimokawa, Takashi Kanaya, Tsuneyasu Kaisho, Hiroshi Ohno
- Organizer
  第42回日本免疫学会学術集会
- Place of Presentation
  千葉県千葉市
- Data Source
  KAKENHI-PROJECT-24249029
[Presentation] The Ets transcription factor Spi-B is essential for M-cell differentiation2012
- Author(s)
  Kanaya Takashi
- Organizer
  第41回日本免疫学会学術集会
- Place of Presentation
  神戸国際会議場、神戸国際展示場（神戸市）
- Data Source
  KAKENHI-PROJECT-23790550
[Presentation] The Ets transcription factor Spi-B is essential for the differentiation of intestinal M cells2012
- Author(s)
  Kanaya Takashi
- Organizer
  第34回内藤コンファレンス
- Place of Presentation
  シャトレーゼガトーキングダムサッポロ（札幌市）
- Data Source
  KAKENHI-PROJECT-23790550
[Presentation] The Ets transcription factor Spi-B is essential for the differentiation of intestinal M cells2012
- Author(s)
  Kanaya Takashi 他
- Organizer
  第34回内藤コンファレンス
- Place of Presentation
  シャトレーゼガトーキングダムサッポロ(札幌市)
- Data Source
  KAKENHI-PROJECT-23790550
[Presentation] The Ets transcription factor Spi-B is essential for M-cell differentiation2012
- Author(s)
  Kanaya Takashi 他,
- Organizer
  第41回日本免疫学会学術集会
- Place of Presentation
  神戸国際会議場、神戸国際展示場(神戸市)
- Data Source
  KAKENHI-PROJECT-23790550

1. OHNO Hiroshi (50233226)

# of Collaborated Projects: 2 results

# of Collaborated Products: 7 results
2. NAKATO Gaku (20584535)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
3. HIDANO Shinya

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
4. 長谷耕二

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
5. 改正恒康

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
6. 星野克明

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

KANAYA TAKASHI 金谷 高史

KANAYA Takashi 金谷 高史

Research Projects

Research Products

Co-Researchers

食物繊維が小腸免疫系を発達させる仕組みの解明Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

The role of Peyer's patch dendritic cells and macropahges in regulation of mucosal immune responsesPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Differentiation and function of M cells, a unique intestinal epithelial cell subset for untigen uptake

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

パイエル板濾胞随伴上皮（FAE）の機能制御を行う微小環境の解明Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

The role of NF-kB signaling in intestinal homeostasisPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Comprehensive understanding of a unique intestinal epithelial M cells specialized for luminal particulate antigen uptake

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Evaluation of the effect of M-cell deficiency by using M-cell-deficient mouse model.Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Book] 実験医学増刊 生体バリア 粘膜や皮膚を舞台とした健康と疾患のダイナミクス2017

Author(s)

Total Pages

Publisher

Data Source

[Book] 実験医学増刊 生体バリア 粘膜や皮膚を舞台とした健康と疾患のダイナミクス2017

Author(s)

Total Pages

Publisher

Data Source

[Book] 臨床免疫・アレルギー科2016

Author(s)

Total Pages

Publisher

Data Source

[Book] 臨床免疫・アレルギー科2016

Author(s)

Total Pages

Publisher

Data Source

[Book] Intech Cytokeratins-Tools in Oncology2012

Author(s)

Publisher

Data Source

[Book] 実験医学増刊 感染・共生・生体防御システム2012

Author(s)

Publisher

Data Source

[Book] 実験医学増刊 感染・共生・生体防御システム2012

Author(s)

Total Pages

Publisher

Data Source

KANAYA TAKASHI 金谷高史

KANAYA Takashi 金谷高史

[Book] 実験医学増刊　生体バリア　粘膜や皮膚を舞台とした健康と疾患のダイナミクス2017

[Book] 実験医学増刊　生体バリア　粘膜や皮膚を舞台とした健康と疾患のダイナミクス2017

[Book] 実験医学増刊感染・共生・生体防御システム2012

[Book] 実験医学増刊感染・共生・生体防御システム2012