• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to previous page

SEKIJIMA Mitsuhiro  関島 光裕

ORCIDConnect your ORCID iD *help
Researcher Number 20568589
Affiliation (Current) 2025: 鹿児島大学, 先端科学研究推進センター, 協力研究者
Affiliation (based on the past Project Information) *help 2022 – 2023: 鹿児島大学, 先端科学研究推進センター, 協力研究者
2016 – 2021: 鹿児島大学, 医用ミニブタ・先端医療開発研究センター, 特任助教
2015: 鹿児島大学, 医用ミニブタ・先端医療開発研究センター, 助教
Review Section/Research Field
Principal Investigator
Basic Section 55010:General surgery and pediatric surgery-related / General surgery
Except Principal Investigator
Medium-sized Section 55:Surgery of the organs maintaining homeostasis and related fields / Basic Section 55040:Respiratory surgery-related / Basic Section 56030:Urology-related / Basic Section 55010:General surgery and pediatric surgery-related / Urology / General surgery
Keywords
Principal Investigator
ミニブタ / 移植・再生医療 / 前臨床研究 / 腎移植 / 慢性移植腎障害 / 3次リンパ組織 / 動脈硬化促進遺伝子導入MHC確立ミニブタ / 動脈硬化モデルミニブタ / ヒトアポリポ蛋白(a) / 動脈硬化 … More / 自然免疫 / 加齢 / MHC / 心移植 / 移植心冠動脈病変 / 虚血再灌流障害 / 臓器灌流保存 / 常温腎臓持続体外灌流保存 / 腎臓体外灌流保存 / 前臨床実験 / 臓器保護 / マージナルドナー / 硫化水素 … More
Except Principal Investigator
ミニブタ / 虚血再灌流障害 / 移植・再生医療 / 肺移植 / 移植・再生 / 腎移植 / 大動物 / トランスレーショナル研究 / 前臨床実験 / アルゴン / 前臨床研究 / 異種移植 / 異種肺移植 / 遺伝子改変ブタ / 異種腎移植 / 免疫寛容誘導 / 遺伝子改変動物 / 臓器保存 / 国際共同研究 / 誘導性気管支関連リンパ節 / 拒絶反応 / 加齢 / 3次リンパ節 / 誘導性気管支関連リンパ組織 / 心停止ドナー / 硫化水素 / 一酸化炭素 / 脳死 / 希ガス / 臓器移植 / 臓器灌流保存 / 浸漬冷却保存 / 温虚血 / 虚血再灌流傷害 / 常温灌流保存 / 移植外科学 / i移植免疫 / 虚血再還流障害 / 移植免疫 / 自然免疫 / ヘムオキシゲナーゼ-1 / 骨髄移植 / 肺胞マクロファージ / マクロファージ / 臓器保護 / 灌流保存 / マージナルドナー Less
  • Research Projects

    (12 results)
  • Research Products

    (27 results)
  • Co-Researchers

    (9 People)
  •  ミニブタを用いた移植腎内3次リンパ組織形成と慢性移植腎障害進展機序の解明Principal Investigator

    • Principal Investigator
      関島 光裕
    • Project Period (FY)
      2022 – 2024
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 55010:General surgery and pediatric surgery-related
    • Research Institution
      Kagoshima University
  •  Association between iBALT formation process and lung injury in aged grafts in large animals.

    • Principal Investigator
      Sahara Hisashi
    • Project Period (FY)
      2021 – 2022
    • Research Category
      Grant-in-Aid for Challenging Research (Exploratory)
    • Review Section
      Medium-sized Section 55:Surgery of the organs maintaining homeostasis and related fields
    • Research Institution
      Kagoshima University
  •  国際研究ネットワークの構築に基づく異種移植実用化戦略の確立

    • Principal Investigator
      佐原 寿史
    • Project Period (FY)
      2021 – 2024
    • Research Category
      Fund for the Promotion of Joint International Research (Fostering Joint International Research (B))
    • Review Section
      Medium-sized Section 55:Surgery of the organs maintaining homeostasis and related fields
    • Research Institution
      Kagoshima University
  •  The protective effect of argon on transplanted kidneys in preclinical models using miniature swine

    • Principal Investigator
      Nobori Shuji
    • Project Period (FY)
      2020 – 2023
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 55010:General surgery and pediatric surgery-related
    • Research Institution
      Kyoto Prefectural University of Medicine
  •  Large animal study to develop a novel inhaled noble gas strategy to protect transplanted lungs

    • Principal Investigator
      Iwanaga Takehiro
    • Project Period (FY)
      2020 – 2022
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 55040:Respiratory surgery-related
    • Research Institution
      Tokyo Medical and Dental University
      Kagoshima University
  •  Preclinical experiments to elucidate the protective effect and mechanism of kidney transplantation by combined administration of gaseous signaling agents

    • Principal Investigator
      ARIYOSHI Yuichi
    • Project Period (FY)
      2020 – 2023
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 56030:Urology-related
    • Research Institution
      Kagoshima University
  •  Preclinical study on organ preconditioning before transplantation for marginal grafts

    • Principal Investigator
      Kusaka Mamoru
    • Project Period (FY)
      2019 – 2021
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 56030:Urology-related
    • Research Institution
      Fujita Health University
  •  To improve the outcome of allogeneic and xenogeneic lung transplantation by elucidating the mechanisms of alveolar macrophages that link the innate and acquired immune systems.

    • Principal Investigator
      SAHARA Hisashi
    • Project Period (FY)
      2019 – 2022
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Review Section
      Basic Section 55040:Respiratory surgery-related
    • Research Institution
      Kagoshima University
  •  Mechanism of development of cardiac allograft vasculopathy following heart transplantation using genetically engineered MHC-defined miniature swine.Principal Investigator

    • Principal Investigator
      SEKIJIMA Mitsuhiro
    • Project Period (FY)
      2018 – 2020
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 55010:General surgery and pediatric surgery-related
    • Research Institution
      Kagoshima University
  •  Development of protection and repair of preserved organs using small interfering RNA (siRNA) in large animal model .

    • Principal Investigator
      Nobori Shuji
    • Project Period (FY)
      2017 – 2019
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      General surgery
    • Research Institution
      Kyoto Prefectural University of Medicine
  •  Normothermic machine perfusion of the kidney to evaluate the donor organ before transplantation: Preclinical large animal study using MHC-defined CLAWN miniature swine

    • Principal Investigator
      ARIYOSHI Yuichi
    • Project Period (FY)
      2017 – 2019
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Urology
    • Research Institution
      Kagoshima University
  •  Establishment of hydrogen sulfide therapy against renal ischemia-reperfusion injury using large animal to attempt to increase the donor organ poolPrincipal Investigator

    • Principal Investigator
      SEKIJIMA Mitsuhiro
    • Project Period (FY)
      2015 – 2017
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      General surgery
    • Research Institution
      Kagoshima University

All 2023 2022 2021 2019 2018 2017 2016

All Journal Article Presentation

  • [Journal Article] Preparation of hybrid porcine thymus containing non-human primate thymic epithelial cells in miniature swine.2019

    • Author(s)
      Sekijima M, Sahara H, Shimizu A, Iwanaga T, Murokawa T, Ariyoshi Y, Pomposelli T, Khosravi Maharlooei M, Sykes M, Yamada K.
    • Journal Title

      Xenotransplantation.

      Volume: 26 Issue: 6

    • DOI

      10.1111/xen.12543

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-19K09722
  • [Journal Article] Hydrogen sulfide prevents renal ischemia-reperfusion injury in CLAWN miniature swine2017

    • Author(s)
      Sekijima Mitsuhiro、Sahara Hisashi、Miki Katsuyuki、Villani Vincenzo、Ariyoshi Yuichi、Iwanaga Takehiro、Tomita Yusuke、Yamada Kazuhiko
    • Journal Title

      Journal of Surgical Research

      Volume: 219 Pages: 165-172

    • DOI

      10.1016/j.jss.2017.05.123

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-15K10032
  • [Presentation] Effect of aging on the progression of pulmonary ischemia-reperfusion injury in CLAWN miniature swine2023

    • Author(s)
      Sahara H, Ichinari Y, Iwanaga T, Sekijima M, Takeuchi K, Shimizu A.
    • Organizer
      International Society for Heart and Lung Transplantation 43rd Annual Meeting
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-21K19536
  • [Presentation] The role of tertiary lymphoid structures in aged swine on the progression of pulmonary ischemia-reperfusion.2023

    • Author(s)
      Sahara H, Takeuchi K, Ichinari Y, Li Z, Kondo A, Sekijima M, Shimizu A.
    • Organizer
      17th Congress IXA (International Xenotransplantation Association 2023)
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-21KK0154
  • [Presentation] 分野別ワークショップここまで来たか!異種移植.「異種移植の臨床応用に向けた展望」.2023

    • Author(s)
      佐原寿史、竹内和博、市成ゆりか、関島光裕、馬 麗娜、李 周宇、清水 章
    • Organizer
      第59回日本移植学会総会
    • Invited
    • Data Source
      KAKENHI-PROJECT-21KK0154
  • [Presentation] シンポジウム⑤ 「異種移植委員会企画」 異種移植の最前線そして臨床応用の課題「異種移植の臨床応用への展望と課題~特に心臓・肺異種移植を中心に」2023

    • Author(s)
      佐原寿史、竹内和博、市成ゆりか、関島光裕、馬 麗娜、李 周宇、清水 章
    • Organizer
      第48回日本臓器保存生物医学会学術集会
    • Invited
    • Data Source
      KAKENHI-PROJECT-21KK0154
  • [Presentation] シンポジウム「実用化を目指した移植・再生医療研究」「ブタを用いた移植研究の現状と課題」2022

    • Author(s)
      佐原寿史, 岩永健裕, 市成ゆりか, 関島光裕, 竹内和博, 清水 章
    • Organizer
      第8回日本先進医工学ブタ研究会
    • Data Source
      KAKENHI-PROJECT-21KK0154
  • [Presentation] Argon Inhalation Reduces Pulmonary Ischemia-Reperfusion Injury in MHC-inbred CLAWN Miniature Swine.2022

    • Author(s)
      Sahara H, Iwanaga T, Sekijima M, Ichinari Y, Shimizu A.
    • Organizer
      International Society for Heart and Lung Transplantation 42nd Annual Meeting
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-20K09169
  • [Presentation] 個体の加齢が肺虚血再灌流障害に及ぼす影響のミニブタによる評価2022

    • Author(s)
      佐原寿史, 岩永健裕, 市成ゆりか, 関島光裕, 竹内和博, 清水 章
    • Organizer
      第48回日本臓器保存生物医学会学術集会.
    • Data Source
      KAKENHI-PROJECT-21K19536
  • [Presentation] Effects of argon inhalation on reducing pulmonary warm ischemia-reperfusion injury in CLAWN miniature swine.2022

    • Author(s)
      Iwanaga T, Sekijima M, Ichinari Y, Kondo A, Shimizu A, Sahara H.
    • Organizer
      TTS2022 (29th International Congress of The Transplantation Society)
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-20K09169
  • [Presentation] Does postoperative inhalation of carbon monoxide prolong pulmonary allograft survival in miniature swine?2022

    • Author(s)
      Sahara H, Sekijima M, Iwanaga T, Ichinari Y, Tasaki M, Takeuchi K, Shimizu A, Yamada K.
    • Organizer
      Transplantation Science Symposium (TSS) Asian Regional Meeting
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-20K09542
  • [Presentation] クラウン系ミニブタを用いた希ガス吸入による肺虚血再灌流障害抑制効果の評価2021

    • Author(s)
      佐原寿史, 岩永健裕, 関島光裕, 市成ゆりか, 清水章
    • Organizer
      第74回日本胸部外科学会定期学術集会
    • Data Source
      KAKENHI-PROJECT-20K09169
  • [Presentation] 分野別シンポジウム9「肺移植におけるドナー不足にどう取組むか」「ドナー臓器不足克服のための異種肺移植研究の現状と課題」2021

    • Author(s)
      佐原寿史, 関島光裕, 岩永健裕. 市成ゆりか, 渡邉洋之助, 清水章
    • Organizer
      第57回日本移植学会総会
    • Data Source
      KAKENHI-PROJECT-19H03748
  • [Presentation] クラウン系ミニブタを用いたアルゴン吸入による肺虚血再灌流障害軽減効果2021

    • Author(s)
      岩永健裕、関島光裕、市成ゆりか、清水章、佐原寿史
    • Organizer
      第68回日本実験動物学会総会
    • Data Source
      KAKENHI-PROJECT-20K09169
  • [Presentation] アルゴンガス吸入によるミニブタ肺虚血再灌流障害抑制効果2021

    • Author(s)
      岩永健裕, 佐原寿史, 関島光裕, 市成ゆりか, 清水章
    • Organizer
      第38回日本呼吸器外科学会総会
    • Data Source
      KAKENHI-PROJECT-20K09169
  • [Presentation] 肺虚血再灌流障害に対するアルゴン吸入の治療効果-クラウン系ミニブタを用いた検討2021

    • Author(s)
      岩永健裕, 佐原寿史, 関島光裕, 市成ゆりか, 清水章
    • Organizer
      第47回日本臓器保存生物医学会学術集会
    • Data Source
      KAKENHI-PROJECT-20K09169
  • [Presentation] クラウン系ミニブタ用いたアルゴン吸入による肺虚血再灌流障害軽減効果2021

    • Author(s)
      岩永健裕, 関島光裕, 市成ゆりか, 清水章, 佐原寿史
    • Organizer
      第68回日本実験動物学会総会
    • Data Source
      KAKENHI-PROJECT-20K09169
  • [Presentation] パネルディスカッション 2 「肺移植における予後改善に向けての取組」「異種肺移植の成績向上を目指した前臨床実験の展望」2021

    • Author(s)
      佐原寿史, 関島光裕, 岩永健裕, 市成ゆりか, 清水章
    • Organizer
      第38回日本呼吸器外科学会総会
    • Data Source
      KAKENHI-PROJECT-19H03748
  • [Presentation] 高度温虚血腎移植に対する22℃臓器保存の有効性-MHC確立クラウン系ミニブタを用いた体外機械灌流および腎移植モデルによる評価.2021

    • Author(s)
      有吉勇一, 関島光裕, 河合彰浩, 岩永健裕,市成ゆりか, 清水 章, 日下 守, 山田和彦, 佐原寿史
    • Organizer
      第47回日本臓器保存生物医学会学術集会
    • Data Source
      KAKENHI-PROJECT-19K09722
  • [Presentation] Effects of static subnormothermic preservation on extended warm ischemic porcine kidneys assessed by normothermic machine perfusion and renal transplantation.2018

    • Author(s)
      Sekijima M, Ariyoshi Y, Sahara H, Kawai A, Iwanaga T, Murokawa T, Ichinari Y, Shimizu A, Kusaka M, Yamada K.
    • Organizer
      TTS2018 (27th International Congress of The Transplantation Society).
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-17K11201
  • [Presentation] MHC確立クラウン系ミニブタを用いた慢性大動物移植実験による常温灌流保存法(NMP法: Normothermic Machine Perfusion)の有効性評価2017

    • Author(s)
      関島光裕, 有吉勇一, 佐原寿史, 岩永健裕, 室川剛廣, 市成ゆりか, 清水 章, 山田和彦
    • Organizer
      第53回日本移植学会総会
    • Data Source
      KAKENHI-PROJECT-17K11201
  • [Presentation] Beneficial effects of hydrogen sulfide (H2S) on renal ischemia-reperfusion Injury (IRI) in CLAWN miniature swine2017

    • Author(s)
      Ariyoshi Y, Sekijima M, Sahara H, Murokawa T, Shimizu A, Yamada K
    • Organizer
      American Transplant Congress 2017
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-15K10032
  • [Presentation] Beneficial effects of hydrogen sulfide (H2S) on renal ischemia-reperfusion injury (IRI) in CLAWN miniature swine.2017

    • Author(s)
      Ariyoshi Y, Sekijima M, Sahara H, Murokawa T, Shimizu A, Yamada K.
    • Organizer
      American Transplant Congress 2017.
    • Place of Presentation
      McCormick Place - Lakeside Center(アメリカ合衆国イリノイ州シカゴ)
    • Year and Date
      2017-04-29
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-15K10032
  • [Presentation] Hydrogen sulfide prevents the kidney from ischemia-reperfusion injury in CLAWN miniature swine2016

    • Author(s)
      Sekijima M, Sahara H, Morita S, Ogawa Y, Miki K, Murokawa T, Iwanaga T, Ichinari Y, Shimizu A, Yamada K
    • Organizer
      26th International Congress of the Transplantation Society
    • Place of Presentation
      Hong Kong ( Hong Kong Convention and Exhibition Centre)
    • Year and Date
      2016-08-20
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-15K10032
  • [Presentation] シンポジウム10. Translational Research. 「硫化水素による新規腎臓保護戦略:臨床応用に向けた大動物実験」2016

    • Author(s)
      関島光裕、佐原寿史、山田和彦
    • Organizer
      第49回日本臨床腎移植学会
    • Place of Presentation
      鳥取県米子市(米子コンベンションセンター)
    • Year and Date
      2016-03-23
    • Data Source
      KAKENHI-PROJECT-15K10032
  • [Presentation] 温虚血腎に対する移植前常温持続灌流の有用性-MHC確立クラウン系ミニブタを用いた慢性腎移植.2016

    • Author(s)
      有吉勇一, 佐原寿史, 関島光裕, 室川剛廣, 岩永健裕, 市成ゆりか, 山田和彦.
    • Organizer
      第4回日本先進医工学ブタ研究会.
    • Place of Presentation
      東レ総合研修センター(静岡県三島市)
    • Year and Date
      2016-10-17
    • Data Source
      KAKENHI-PROJECT-15K10032
  • [Presentation] Hydrogen sulfide prevents the kidney from ischemia-reperfusion injury in CLAWN miniature swine.2016

    • Author(s)
      Sekijima M, Sahara H, Morita S, Ogawa Y, Miki K, Murokawa T, Iwanaga T, Ichinari Y, Shimizu A, Yamada K.
    • Organizer
      26th International Congress of the Transplantation Society.
    • Place of Presentation
      香港会議展覧中心(中国香港)
    • Year and Date
      2016-08-20
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-15K10032
  • 1.  SAHARA Hisashi (90452333)
    # of Collaborated Projects: 12 results
    # of Collaborated Products: 27 results
  • 2.  Iwanaga Takehiro (40518916)
    # of Collaborated Projects: 7 results
    # of Collaborated Products: 11 results
  • 3.  山田 和彦 (40241103)
    # of Collaborated Projects: 6 results
    # of Collaborated Products: 11 results
  • 4.  ARIYOSHI Yuichi (10643520)
    # of Collaborated Projects: 5 results
    # of Collaborated Products: 2 results
  • 5.  Shimizu Akira (00256942)
    # of Collaborated Projects: 3 results
    # of Collaborated Products: 10 results
  • 6.  Nobori Shuji (30433288)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 0 results
  • 7.  奥見 雅由 (60512978)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 0 results
  • 8.  竹内 和博 (50648772)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 4 results
  • 9.  Kusaka Mamoru (40309141)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 1 results

URL: 

Are you sure that you want to link your ORCID iD to your KAKEN Researcher profile?
* This action can be performed only by the researcher himself/herself who is listed on the KAKEN Researcher’s page. Are you sure that this KAKEN Researcher’s page is your page?

この研究者とORCID iDの連携を行いますか?
※ この処理は、研究者本人だけが実行できます。

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi