Takahashi Nobunori 高橋伸典

… Alternative Names

TAKAHASHI Nobunori 高橋伸典

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Researcher Number	20570196
Other IDs
Affiliation (Current)	2025: 愛知医科大学, 医学部, 教授
Affiliation (based on the past Project Information) *help	2021 – 2024: 愛知医科大学, 医学部, 教授 2021: 名古屋大学, 医学部附属病院, 病院講師 2020 – 2021: 名古屋大学, 医学系研究科, 准教授 2015 – 2019: 名古屋大学, 医学部附属病院, 病院講師 2012 – 2014: 名古屋大学, 医学部附属病院, 助教 2011 – 2012: 名古屋大学, 医学部附属病院, 病院助教
Review Section/Research Field	Principal Investigator Orthopaedic surgery / Basic Section 56020:Orthopedics-related Except Principal Investigator Basic Section 56020:Orthopedics-related / Orthopaedic surgery / Basic Section 57060:Surgical dentistry-related / Basic Section 54010:Hematology and medical oncology-related
Keywords	Principal Investigator CD44 / ヒアルロン酸 / 関節軟骨変性 / 変形性関節症 / CD44断片化 / 断片化 / 関節軟骨変性の抑制 / ADAM10 / メカニカルストレス / 関節軟骨変性抑制 … More / CD44の断片化 / スタチン / CD44の断片化抑制 / Statin製剤 / Lipid Raft … More Except Principal Investigator 変形性関節症 / Drug repositioning / 関節再生 / 軟骨細胞 / Wnt/βcatenin / 関節リウマチ / 免疫細胞 / 骨軟骨再生 / 間葉系幹細胞 / 次空間的遺伝子解析 / 滑膜線維芽細胞 / 分泌型シアル酸認識レクチン / 関節炎 / 破骨細胞 / Siglec9 / M2マクロファージ / レクチン / シアル酸認識レクチン / 幹細胞培養上清 / 滑膜マクロファージ / トロンビン生成試験 / 凝固一段法 / 合成基質法 / 凝固因子 / 関節エコー / 関節症 / 血友病 / 血液凝固検査 / 遺伝子解析 / 血友病A / 4-Methylumbelliferone / 外因性hyaluronan / 軟骨変性 / 嫌気性解糖 / ヒアルロン酸 / 代謝リプログラミング / CD44断片化抑制 / Wnt/βカテニン抑制 / Wntシグナル / DKK1 / β - catenin / Wnt signal / Dkk1 / RunxII / 神経軸索伸長 / drug reposionning / 希少疾患 / CD44断片化 / Sox9 / Runx II / 生物学的製剤 / 骨代謝 / 臨床 / toll like receptor / denosumab / osteoporosis / biologics / rheumatoid arthritis Less

時空間的遺伝子発現解析による関節再生メカニズムの検証
- Principal Investigator
  
  山本朗仁
- Project Period (FY)
  2024 – 2026
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 57060:Surgical dentistry-related
- Research Institution
  The University of Tokushima
ヒアルロン酸レセプターCD44の断片化阻害による、関節軟骨変性抑制効果Principal Investigator
- Principal Investigator
  
  高橋伸典
- Project Period (FY)
  2023 – 2025
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 56020:Orthopedics-related
- Research Institution
  Aichi Medical University
Elucidation of the pathogenesis of hemophilic arthropathy and development of unmet needs by focusing on the divergence of activity levels.
- Principal Investigator
  
  Suzuki Nobuaki
- Project Period (FY)
  2021 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 54010:Hematology and medical oncology-related
- Research Institution
  Nagoya University
Analysis of joint regeneration mechanism by secretory sialic acid recognition lectin
- Principal Investigator
  
  YAMAMOTO Akihito
- Project Period (FY)
  2021 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 56020:Orthopedics-related
- Research Institution
  The University of Tokushima
外因性hyaluronanの軟骨細胞における役割の解明
- Principal Investigator
  
  横田裕
- Project Period (FY)
  2020
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 56020:Orthopedics-related
- Research Institution
  Nagoya University
The suppressive effect on chondrocyte dedifferentiation by preventing the fragmentation of hyaluronan receptor CD44Principal Investigator
- Principal Investigator
  
  Takahashi Nobunori
- Project Period (FY)
  2019 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 56020:Orthopedics-related
- Research Institution
  Aichi Medical University
  Nagoya University
Development of a new therapeutic drug for osteoarthritis that has a cartilage-protecting effect by inhibiting Wnt/ADAM10
- Principal Investigator
  
  ISHIGURO Naoki
- Project Period (FY)
  2019 – 2021
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 56020:Orthopedics-related
- Research Institution
  Nagoya University
Inhibition of CD44 cleavage suppresses the chondrocyte de-differentiationPrincipal Investigator
- Principal Investigator
  
  Takahashi Nobunori
- Project Period (FY)
  2016 – 2018
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Orthopaedic surgery
- Research Institution
  Nagoya University
New medical development of orthopedics area by drug repositioning strategy
- Principal Investigator
  
  ISHIGURO NAOKI
- Project Period (FY)
  2016 – 2018
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Orthopaedic surgery
- Research Institution
  Nagoya University
Development of a new drug for treating osteoarthritis caused by increased expression of Dkk1 molecule
- Principal Investigator
  
  Ishiguro Naoki
- Project Period (FY)
  2016 – 2017
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Orthopaedic surgery
- Research Institution
  Nagoya University
Inhibitory effects of combination therapy of denosumab, anti-RANKL antibody, and biological DMARD on bone and cartilage destruction in patients with rheumatoid arthritis
- Principal Investigator
  
  Kojima Toshihisa
- Project Period (FY)
  2014 – 2016
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Orthopaedic surgery
- Research Institution
  Nagoya University
Inhibition of CD44 cleavage suppresses the chondrocyte de-differentiationPrincipal Investigator
- Principal Investigator
  
  Takahashi Nobunori
- Project Period (FY)
  2013 – 2015
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Orthopaedic surgery
- Research Institution
  Nagoya University
Inhibition of CD44 cleavage suppresses the chondrocyte de-differentiationPrincipal Investigator
- Principal Investigator
  
  TAKAHASHI Nobunori
- Project Period (FY)
  2011 – 2012
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Orthopaedic surgery
- Research Institution
  Nagoya University

All 2022 2021 2020 2019 2018 2017 2016 2015 2014 2013 Other

All Journal Article Presentation Book

[Book] 株式会社アークメディア2016
- Author(s)
  高橋伸典,石黒直樹
- Total Pages
  7
- Publisher
  【先読み!「早期変形性膝関節症」】（Part５）治療膝ＯＡに対する抗ＮＧＦ抗体
- Data Source
  KAKENHI-PROJECT-16K10897
[Journal Article] Effectiveness of tacrolimus concomitant with biological disease-modifying antirheumatic drugs in patients with rheumatoid arthritis2022
- Author(s)
  Terabe Kenya、Takahashi Nobunori、Asai Shuji、Hirano Yuji、Kanayama Yasuhide、Yabe Yuichiro、Oguchi Takeshi、Fujibayashi Takayoshi、Ishikawa Hisato、Hanabayashi Masahiro、Hattori Yosuke、Suzuki Mochihito、Kishimoto Kenji、Ohashi Yoshifumi、Imaizumi Takahiro、Imagama Shiro、Kojima Toshihisa
- Journal Title
  
  Modern Rheumatology
  
  Volume: - Issue: 2 Pages: 292-301
- DOI
  10.1093/mr/roac025
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19H03779
[Journal Article] A case of synovitis, acne, pustulosis, hyperostosis, and osteitis (SAPHO) syndrome with isolated lesions of the thoracic spine2022
- Author(s)
  Hattori Kyosuke、Takahashi Nobunori、Suzuki Mochihito、Kojima Toshihisa、Imagama Shiro
- Journal Title
  
  Modern Rheumatology Case Reports
  
  Volume: - Issue: 1 Pages: 243-246
- DOI
  10.1093/mrcr/rxac030
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19H03779
[Journal Article] Relationship between locomotive syndrome and frailty in rheumatoid arthritis patients by locomotive syndrome stage2021
- Author(s)
  Sobue Yasumori、Suzuki Mochihito、Ohashi Yoshifumi、Koshima Hiroshi、Okui Nobuyuki、Funahashi Koji、Ishikawa Hisato、Asai Shuji、Terabe Kenya、Yokota Yutaka、Kishimoto Kenji、Takahashi Nobunori、Imagama Shiro、Kojima Toshihisa
- Journal Title
  
  Modern Rheumatology
  
  Volume: 32 Issue: 3 Pages: 546-553
- DOI
  10.1093/mr/roab024
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19H03779, KAKENHI-PROJECT-23K20339
[Journal Article] Higher doses of methotrexate associated with discontinuation of oral glucocorticoids after initiation of biological DMARDs: A retrospective observational study based on data from a Japanese multicenter registry study2021
- Author(s)
  Suzuki M、Kojima T、Takahashi Nobunori、Asai S、Terabe K、Kaneko A、Hirano Y、Hanabayashi M、Oguchi T、Takagi H、Kanayama Y、Yabe Y、Funahashi K、Fujibayashi T、Tsuboi S、Ito T、Yoshioka Y、Ishikawa H、Sobue Yi、Nishiume T、Yokota Y、Ishiguro Naoki
- Journal Title
  
  Modern Rheumatology
  
  Volume: 31 Issue: 4 Pages: 796-802
- DOI
  10.1080/14397595.2021.1879428
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19H03779, KAKENHI-PROJECT-19K18496
[Journal Article] Metabolic changes in synovial cells in early inflammation: Involvement of CREB phosphorylation in the anti-inflammatory effect of 2-deoxyglucose2021
- Author(s)
  Kishimoto Kenji、Terabe Kenya、Takahashi Nobunori、Yokota Yutaka、Ohashi Yoshifumi、Hattori Kyosuke、Kihira Daisuke、Maeda Masataka、Kojima Toshihisa、Imagama Shiro
- Journal Title
  
  Archives of Biochemistry and Biophysics
  
  Volume: 708 Pages: 108962-108962
- DOI
  10.1016/j.abb.2021.108962
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19H03779, KAKENHI-PROJECT-19K09619, KAKENHI-PROJECT-19K09620, KAKENHI-PROJECT-20K18061
[Journal Article] Comparison of the effects of baricitinib and tocilizumab on disease activity in patients with rheumatoid arthritis: a propensity score matching analysis2021
- Author(s)
  Asai S、Takahashi N、Kobayakawa T、Kaneko A、Watanabe T、Kato T、Nishiume T、Ishikawa H、Yoshioka Y、Kanayama Y、Watanabe T、Hirano Y、Hanabayashi M、Yabe Y、Yokota Y、Suzuki M、Terabe K、Ishiguro Naoki、Imagama S、Kojima T
- Journal Title
  
  Clinical Rheumatology
  
  Volume: 40 Issue: 8 Pages: 3143-3151
- DOI
  10.1007/s10067-021-05815-3
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19H03779
[Journal Article] Metabolic reprogramming in chondrocytes to promote mitochondrial respiration reduces downstream features of osteoarthritis2021
- Author(s)
  Ohashi Yoshifumi、Takahashi Nobunori、Terabe Kenya、Tsuchiya Saho、Kojima Toshihisa、Knudson Cheryl B.、Knudson Warren、Imagama Shiro
- Journal Title
  
  Scientific Reports
  
  Volume: 11 Issue: 1 Pages: 15131-15131
- DOI
  10.1038/s41598-021-94611-9
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19H03779, KAKENHI-PROJECT-19K09619, KAKENHI-PROJECT-19K09620, KAKENHI-PROJECT-20K18061
[Journal Article] Predictive factors for achievement of treatment goals in patients with postmenopausal osteoporosis treated with denosumab2021
- Author(s)
  Hattori Kyosuke、Takahashi Nobunori、Kojima Toshihisa、Imagama Shiro
- Journal Title
  
  Modern Rheumatology
  
  Volume: - Issue: 1 Pages: 217-223
- DOI
  10.1093/mr/roab129
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19H03779
[Journal Article] Activation of transient receptor potential vanilloid 4 protects articular cartilage against inflammatory responses via CaMKK/AMPK/NF-κB signaling pathway2021
- Author(s)
  Hattori Kyosuke、Takahashi Nobunori、Terabe Kenya、Ohashi Yoshifumi、Kishimoto Kenji、Yokota Yutaka、Suzuki Mochihito、Kojima Toshihisa、Imagama Shiro
- Journal Title
  
  Scientific Reports
  
  Volume: 11 Issue: 1 Pages: 15508-15508
- DOI
  10.1038/s41598-021-94938-3
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19H03779, KAKENHI-PROJECT-19K09619, KAKENHI-PROJECT-19K09620, KAKENHI-PROJECT-19K18496
[Journal Article] Hyaluronan suppresses enhanced cathepsin K expression via activation of NF-κB with mechanical stress loading in a human chondrocytic HCS-2/8 cells2020
- Author(s)
  Suzuki Mochihito、Takahashi Nobunori、Sobue Yasumori、Ohashi Yoshifumi、Kishimoto Kenji、Hattori Kyosuke、Ishiguro Naoki、Kojima Toshihisa
- Journal Title
  
  Scientific Reports
  
  Volume: 10 Issue: 1 Pages: 216-216
- DOI
  10.1038/s41598-019-57073-8
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K09620, KAKENHI-PROJECT-19H03779
[Journal Article] Factors associated with osteophyte formation in patients with rheumatoid arthritis undergoing total knee arthroplasty2020
- Author(s)
  Asai Nobuyuki、Asai Shuji、Takahashi Nobunori、Ishiguro Naoki、Kojima Toshihisa
- Journal Title
  
  Modern Rheumatology
  
  Volume: 30 Issue: 5 Pages: 937-939
- DOI
  10.1080/14397595.2019.1673132
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19H03779
[Journal Article] Periarticular osteophyte formation protects against total knee arthroplasty in rheumatoid arthritis patients with advanced joint damage2020
- Author(s)
  Asai Shuji、Takahashi Nobunori、Terabe Kenya、Sobue Yasumori、Nishiume Tsuyoshi、Suzuki Mochihito、Yokota Yutaka、Ishiguro Naoki、Kojima Toshihisa
- Journal Title
  
  Clinical Rheumatology
  
  Volume: 39(11) Issue: 11 Pages: 3331-3339
- DOI
  10.1007/s10067-020-05140-1
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19H03779
[Journal Article] Longitudinal changes in pulmonary function and respiratory impedance of rheumatoid arthritis2019
- Author(s)
  Isobe Yoshitaka、Ito Satoru、Matsuda Toshiaki、Iwano Shingo、Uchida Akemi、Takahashi Nobunori、Kojima Toshihisa、Wakahara Keiko、Yamaguchi Etsuro、Hasegawa Yoshinori
- Journal Title
  
  Respiratory Physiology & Neurobiology
  
  Volume: 261 Pages: 1-8
- DOI
  10.1016/j.resp.2018.12.008
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-16H05446
[Journal Article] Simvastatin promotes restoration of chondrocyte morphology and phenotype2019
- Author(s)
  Terabe Kenya、Takahashi Nobunori、Cobb Michelle、Askew Emily B.、Knudson Cheryl B.、Knudson Warren
- Journal Title
  
  Archives of Biochemistry and Biophysics
  
  Volume: 665 Pages: 1-11
- DOI
  10.1016/j.abb.2019.01.038
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16H05446, KAKENHI-PROJECT-19K09620
[Journal Article] Inhibition of CD44 intracellular domain production suppresses bovine articular chondrocyte de-differentiation induced by excessive mechanical stress loading2019
- Author(s)
  Sobue Yasumori、Takahashi Nobunori、Ohashi Yoshifumi、Suzuki Mochihito、Nishiume Tsuyoshi、Kobayakawa Tomonori、Terabe Kenya、Knudson Warren、Knudson Cheryl、Ishiguro Naoki、Kojima Toshihisa
- Journal Title
  
  Scientific Reports
  
  Volume: 9 Issue: 1 Pages: 14901-14901
- DOI
  10.1038/s41598-019-50166-4
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K09620, KAKENHI-PROJECT-19H03779
[Journal Article] Hyaluronan promotes TRPV4-induced chondrogenesis in ATDC5 cells2019
- Author(s)
  Ogawa Yoshikazu、Takahashi Nobunori、Takemoto Toki、Nishiume Tsuyoshi、Suzuki Mochihito、Ishiguro Naoki、Kojima Toshihisa
- Journal Title
  
  PLOS ONE
  
  Volume: 14 Issue: 8 Pages: e0219492-e0219492
- DOI
  10.1371/journal.pone.0219492
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K09620
[Journal Article] Association between chest computed tomography findings and respiratory adverse events in rheumatoid arthritis patients undergoing long-term biological therapy2018
- Author(s)
  Matsumoto Takuya、Iwano Shingo、Takahashi Nobunori、Asai Shuji、Watanabe Tatsuo、Asai Nobuyuki、Sobue Yasumori、Ito Satoru、Ishiguro Naoki、Kojima Toshihisa
- Journal Title
  
  International Journal of Rheumatic Diseases
  
  Volume: November Issue: 4 Pages: 1-10
- DOI
  10.1111/1756-185x.13434
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-16H05446
[Journal Article] Influence of methotrexate on gastrointestinal symptoms in patients with rheumatoid arthritis2018
- Author(s)
  Asai Shuji、Nagai Kaoru、Takahashi Nobunori、Watanabe Tatsuo、Matsumoto Takuya、Asai Nobuyuki、Sobue Yasumori、Ishiguro Naoki、Kojima Toshihisa
- Journal Title
  
  International Journal of Rheumatic Diseases
  
  Volume: 22 Issue: 2 Pages: 207-213
- DOI
  10.1111/1756-185x.13380
- NAID
  120006648041
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-16H05446
[Journal Article] Clinical effectiveness and long-term retention of abatacept in elderly rheumatoid arthritis patients: Results from a multicenter registry system2018
- Author(s)
  Takahashi N、Kojima T、Kida D、Kaneko A、Hirano Y、Fujibayashi T、Yabe Y、Takagi H、Oguchi T、Hanabayashi M、Kato T、Funahashi K、Hayashi M、Tsuboi S、Kanayama Y、Sobue Y、Asai N、Matsumoto T、Watanabe T、Asai S、Ishiguro N
- Journal Title
  
  Modern Rheumatology
  
  Volume: 15 Issue: 6 Pages: 1-23
- DOI
  10.1080/14397595.2018.1525019
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-16H05446
[Journal Article] An Open-label Single-arm Trial of a Novel Extramedullary Guide Coordinated with 3D Surgical Assistive Software for Total Knee Arthroplasty2018
- Author(s)
  Kida D1, Hashimoto H, Saito AM, Kito Y, Mori K, Terabe K, Takahashi N, Tomita Y.
- Journal Title
  
  Acta Medica Okayama
  
  Volume: 72 Issue: 4 Pages: 441-445
- DOI
  10.18926/AMO/56186
- NAID
  120006501294
- URL
  https://ousar.lib.okayama-u.ac.jp/56186
- Language
  English
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-16H05446
[Journal Article] An Open-Label, Single-Arm Study of a Patient-Specific Femoral Guide for Total Hip Arthroplasty via the Anterolateral Supine Approach, Linked with Three-Dimensional Surgical Support Software: Study Protocol2018
- Author(s)
  KIDA DAIHEI、HASHIMOTO HIROYA、ITO NORIKO、KITO YUKARI、MORI KOUICHI、TAKAHASHI NOBUNORI、TOMITA YASUSHI
- Journal Title
  
  The Kurume Medical Journal
  
  Volume: 65 Issue: 2 Pages: 71-75
- DOI
  10.2739/kurumemedj.MS652002
- NAID
  130007650018
- ISSN
  0023-5679, 1881-2090
- Year and Date
  2018-06-30
- Language
  English
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-16H05446
[Journal Article] Predictors of biologic discontinuation due to insufficient response in patients with rheumatoid arthritis who achieved clinical remission with biologic treatment: A multicenter observational cohort study2017
- Author(s)
  Asai S, Fujibayashi T, Oguchi T, Hanabayashi M, Hayashi M, Matsubara H, Ito T, Yabe Y, Watanabe T, Hirano Y, Kanayama Y, Kaneko A, Kato T, Takagi H, Takahashi N, Funahashi K, Takemoto T, Asai N, Watanabe T, Ishiguro N, Kojima T
- Journal Title
  
  Mod Rheumatol.
  
  Volume: 28(2) Issue: 2 Pages: 221-226
- DOI
  10.1080/14397595.2017.1332558
- NAID
  120006648042
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-16K15661, KAKENHI-PROJECT-16H05446
[Journal Article] 小児膝伸展機構損傷後に膝蓋腱骨化を生じた２例2017
- Author(s)
  宮本健太郎，小田智之，黒河内和俊，高橋成夫，平岩秀樹，濱田恭，山下暁士，岸本烈純，土谷早穂，酒井忠博
- Journal Title
  
  JOSKAS
  
  Volume: 42(2) Pages: 364-365
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16K15661
[Journal Article] High rate of improvement in serum matrix metalloproteinase-3 levels at 4 weeks predicts remission at 52 weeks in RA patients treated with adalimumab2017
- Author(s)
  Hattori Yosuke、Kojima Toshihisa、Kaneko Atsushi、Kida Daihei、Hirano Yuji、Fujibayashi Takayoshi、Yabe Yuichiro、Oguchi Takeshi、Kanayama Yasuhide、Miyake Hiroyuki、Kato Takefumi、Takagi Hideki、Hayashi Masatoshi、Ito Takayasu、Shioura Tomone、Takahashi Nobunori、Ishikawa Hisato、Funahashi Koji、Ishiguro Naoki
- Journal Title
  
  Mod Rheumatol
  
  Volume: 28 Issue: 1 Pages: 119-125
- DOI
  10.1080/14397595.2017.1317320
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-16K15661, KAKENHI-PROJECT-16H05446
[Journal Article] mproved safety of biologic therapy for rheumatoid arthritis over the 8-year period since implementation in Japan: long-term results from a multicenter observational cohort study2016
- Author(s)
  Kojima, T., Takahashi, N., Funahashi, K., Asai, S., Terabe, K., Kaneko, A., Hirano, Y., Hayashi, M., Miyake, H., Oguchi, T., Takagi, H., Kanayama, Y., Yabe, Y., Watanabe, T., Fujibayashi, T., Shioura, T., Ito, T., Yoshioka, Y., Ishikawa, H., Asai, N., Takemoto, T., Kojima, M., Ishiguro, N.
- Journal Title
  
  Clinical Rheumatology
  
  Volume: 35 Issue: 4 Pages: 863-71
- DOI
  10.1007/s10067-016-3201-5
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-26462290, KAKENHI-PROJECT-25861307, KAKENHI-PROJECT-26460608
[Journal Article] Soluble Siglec-9 suppresses arthritis in a collagen-induced arthritis mouse model and inhibits M1 activation of RAW264.7 macrophages.2016
- Author(s)
  Matsumoto T, Takahashi N, Kojima T, Yoshioka Y, Ishikawa J, Furukawa K, Ono K, Sawada M, Ishiguro N, Yamamoto A.
- Journal Title
  
  Arthritis Research & Therapy
  
  Volume: 18（１） Issue: 1 Pages: 133-133
- DOI
  10.1186/s13075-016-1035-9
- NAID
  120006937643
- Peer Reviewed / Acknowledgement Compliant / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K10897, KAKENHI-PROJECT-15K15080
[Journal Article] Hyaluronan Oligosaccharides Induce MMP-1 and -3 via Transcriptional Activation of NF-κB and p38 MAPK in Rheumatoid Synovial Fibroblasts.2016
- Author(s)
  Hanabayashi M, Takahashi N, Sobue Y, Hirabara S, Ishiguro N, Kojima T.
- Journal Title
  
  PLOS ONE
  
  Volume: 11（８） Issue: 8 Pages: e0161875-e0161875
- DOI
  10.1371/journal.pone.0161875
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-16K10897
[Journal Article] Mechanical stress loading induces CD44 cleavage in human chondrocytic HCS-2/8 cells.2016
- Author(s)
  Kobayakawa T, Takahashi N, Sobue Y, Terabe K, Ishiguro N, Kojima T.
- Journal Title
  
  Biochemical and Biophysical Research Communications
  
  Volume: 478(3) Issue: 3 Pages: 1230-1235
- DOI
  10.1016/j.bbrc.2016.08.099
- NAID
  120006305561
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16H05446, KAKENHI-PROJECT-16K10897
[Journal Article] Hyaluronan Inhibits Tlr-4-Dependent RANKL Expression in Human Rheumatoid Arthritis Synovial Fibroblasts2016
- Author(s)
  Tatsuo Watanabe, Nobunori Takahashi, Shinya Hirabara, Naoki Ishiguro, Toshihisa Kojima
- Journal Title
  
  PLOS ONE
  
  Volume: in press Issue: 4 Pages: e0153142-e0153142
- DOI
  10.1371/journal.pone.0153142
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-25462366, KAKENHI-PROJECT-26462290, KAKENHI-PROJECT-16K10897
[Journal Article] Predictive factors for achieving low disease activity at 52 weeks after switching from tumor necrosis factor inhibitors to abatacept: results from a multicenter observational cohort study of Japanese patients2016
- Author(s)
  Kojima, T., Takahashi, N., Kaneko, A., Kida, D., Hirano, Y., Fujibayashi, T., Yabe, Y., Takagi, H., Oguchi, T., Miyake, H., Kato, T., Watanabe, T., Hayashi, M., Shioura, T., Kanayama, Y., Funahashi, K., Asai, S., Yoshioka, Y., Terabe, K., Takemoto, T., Asai, N., Ishiguro, N.
- Journal Title
  
  Clinical Rheumatology
  
  Volume: 35 Issue: 1 Pages: 219-25
- DOI
  10.1007/s10067-015-3135-3
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-26462290, KAKENHI-PROJECT-24249076, KAKENHI-PROJECT-26670660, KAKENHI-PROJECT-25861307
[Journal Article] Simvastatin inhibits CD44 fragmentation in chondrocytes.2016
- Author(s)
  Terabe K, Takahashi N, Takemoto T, Knudson W, Ishiguro N, Kojima T.
- Journal Title
  
  Archives of Biochemistry and Biophysics
  
  Volume: 604 Pages: 1-10
- DOI
  10.1016/j.abb.2016.05.019
- NAID
  120005868236
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16H05446, KAKENHI-PROJECT-16K10897
[Journal Article] Longterm Retention Rate and Risk Factors for Adalimumab Discontinuation Due To Efficacy and Safety in Japanese Patients with Rheumatoid Arthritis: An Observational Cohort Study.2016
- Author(s)
  Hattori Y, Kojima T, Kaneko A, Kida D, Hirano Y, Fujibayashi T, Terabe K, Yabe Y, Miyake H, Kato T, Takagi H, Hayashi M, Ito T, Kanayama Y, Oguchi T, Takahashi N, Ishikawa H, Funahashi K, Ishiguro N.
- Journal Title
  
  The Journal of Rheumatology
  
  Volume: 43(8) Issue: 8 Pages: 1475-9
- DOI
  10.3899/jrheum.151006
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16H05446, KAKENHI-PROJECT-26462290
[Journal Article] Hyaluronan Oligosaccharides Induce MMP-1 and -3 via Transcriptional Activation of NF-kappaB and p38 MAPK in Rheumatoid Synovial Fibroblasts.2016
- Author(s)
  Hanabayashi M, Takahashi N, Sobue Y, Hirabara S, Ishiguro N, Kojima T.
- Journal Title
  
  PLoS One
  
  Volume: 11（８）
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-26462290
[Journal Article] Importance of methotrexate therapy concomitant with tocilizumab treatment in achieving better clinical outcomes for rheumatoid arthritis patients with high disease activity: an observational cohort study2015
- Author(s)
  Kojima, T.,Yabe, Y.,Kaneko, A.,Takahashi, N.,Funahashi, K.,Kato, D.,Hanabayashi, M.,Asai, S.,Hirabara, S.,,Asai, ,.Hirano, Y.,Hayashi, M.,Miyake, H.,Kojima, M.,Ishiguro, N.
- Journal Title
  
  Rheumatology (Oxford)
  
  Volume: 54（1） Issue: 1 Pages: 113-120
- DOI
  10.1093/rheumatology/keu302
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-25861307, KAKENHI-PROJECT-26462290, KAKENHI-PROJECT-26460608
[Journal Article] Drug retention rates of second biologic agents after switching from tumor necrosis factor inhibitors for rheumatoid arthritis in Japanese patients on low-dose methotrexate or without methotrexate2015
- Author(s)
  Kobayakawa, T.,Kojima, T.,Takahashi, N.,Hayashi, M.,Yabe, Y.,Kaneko, A.,Shioura, T.,Saito, K.,Hirano, Y.,Kanayama, Y.,Miyake, H.,Asai, N.,Funahashi, K.,Hirabara, S.,Hanabayashi, M.,Asai, S.,Ishiguro, N.
- Journal Title
  
  Mod Rheumatol
  
  Volume: 25（2） Issue: 2 Pages: 251-256
- DOI
  10.3109/14397595.2014.953668
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-25861307, KAKENHI-PROJECT-26462290
[Journal Article] Clinical efficacy of abatacept, tocilizumab, and etanercept in Japanese rheumatoid arthritis patients with inadequate response to anti-TNF monoclonal antibodies2014
- Author(s)
  Y.,Fujibayashi, T.,Sugiura, F.,Hayashi, M.,Funahashi, K.,Hanabayashi, M.,Asai, S.,Ishiguro, N.,Kojima, T.
- Journal Title
  
  Clin Rheumatol
  
  Volume: 33（９） Issue: 9 Pages: 1247-1254
- DOI
  10.1007/s10067-014-2711-2
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-25861307, KAKENHI-PROJECT-26462290
[Journal Article] Longterm retention rate and risk factor for discontinuation due to insufficient efficacy and adverse events in Japanese patients with rheumatoid arthritis receiving etanercept therapy2014
- Author(s)
  Matsubara H, Kojima T, Kaneko A, Hirano Y, Ishikawa H, Hattori Y, Miyake H, Oguchi T, Takagi H, Yabe Y, Kato T, Ito T, Fukaya N, Kanayama Y, Shioura T, Hayashi M, Fujibayashi T, Takahashi N, Funahashi K, Kato D, Hanabayashi M, Terabe K, Ishiguro N.
- Journal Title
  
  J Rheumatol
  
  Volume: 41 Issue: 8 Pages: 1583-9
- DOI
  10.3899/jrheum.130901
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-26462290
[Presentation] Metabolic reprogramming via glutamine metabolism in chondrocytes under inflammatory conditions2022
- Author(s)
  Kihira Daisuke;Nobunori Takahashi;Kenya Terabe; Toshihisa Kojima;Yoshifumi Ohashi;Masataka Maeda;Ryo Sato;Hironobu Kosugiyama;Jyunya Hasegawa;Shiro Imagama
- Organizer
  Orthopaedic Research Society 2021 Annual Meeting Registration
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K09620
[Presentation] 軟骨細胞におけるグルタミン代謝阻害による抗炎症作用の検討2022
- Author(s)
  紀平　大介、高橋　伸典、寺部　健哉、大橋　禎史、小嶋　俊久、今釜　史郎
- Organizer
  第 34 回日本軟骨代謝学会
- Data Source
  KAKENHI-PROJECT-19K09620
[Presentation] 関節炎の炎症抑制における脂肪酸代謝の関与2022
- Author(s)
  佐藤　良、寺部　健哉、大橋　禎史、高橋　伸典、小嶋　俊久、今釜　史郎
- Organizer
  第 34 回日本軟骨代謝学会
- Data Source
  KAKENHI-PROJECT-19K09620
[Presentation] 高分子ヒアルロン酸のNF-kB経路に対する影響の検討2022
- Author(s)
  小杉山　裕亘、高橋　伸典、寺部　健哉、大橋　禎史、小嶋　俊久
- Organizer
  第 34 回日本軟骨代謝学会
- Data Source
  KAKENHI-PROJECT-19K09620
[Presentation] Metabolic Reprogramming In Chondrocytes To Promote Mitochondrial Respiration Reduces Downstream Features Of Osteoarthritis2022
- Author(s)
  Yoshifumi Ohashi; Nobunori Takahashi; Kenya Terabe; Saho Tsuchiya; Toshihisa Kojima; Warren Knudson; Cheryl Knudson; Shiro Imagama
- Organizer
  Orthopaedic Research Society 2021 Annual Meeting Registration
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K09620
[Presentation] AICARの軟骨保護には細胞内代謝の変化が関係する2022
- Author(s)
  前田　真崇、寺部　健哉、浅井　秀司、高橋　伸典、小嶋　俊久、今釜　史郎
- Organizer
  第 34 回日本軟骨代謝学会
- Data Source
  KAKENHI-PROJECT-19K09620
[Presentation] 変形性膝関節症のヒアルロン酸治療　―分子生物学的理解―2021
- Author(s)
  高橋伸典
- Organizer
  第36回日本整形外科学会基礎学術集会
- Data Source
  KAKENHI-PROJECT-19K09620
[Presentation] 鏡視下足関節固定術の小経験2020
- Author(s)
  井戸田大，黒河内和俊, 宮本健太郎, 中島基成, 高橋成夫, 平岩秀樹, 石塚真哉, 熊井司
- Organizer
  第12回日本関節鏡・膝・スポーツ整形外科学会
- Data Source
  KAKENHI-PROJECT-19H03779
[Presentation] 炎症下における滑膜細胞の代謝リプログラミング(会議録)2020
- Author(s)
  岸本賢治, 高橋伸典, 寺部健哉, 小嶋俊久
- Organizer
  第35回日本整形外科学会基礎学術集会
- Data Source
  KAKENHI-PROJECT-19H03779
[Presentation] IL-1β存在下におけるTRPV4活性化の軟骨破壊に対する役割の検討(会議録)2020
- Author(s)
  服部恭典, 高橋伸典, 寺部健哉, 小嶋俊久
- Organizer
  第35回日本整形外科学会基礎学術集会
- Data Source
  KAKENHI-PROJECT-19H03779
[Presentation] 若年女性における前十字靭帯再建後の伸展制限2020
- Author(s)
  水野隆文、黒河内和俊, 高橋成夫, 平岩秀樹, 石塚真哉, 山下暁士, 大羽宏樹, 川村佑介, 小早川晃範, 坂口健史, 井戸田大
- Organizer
  第12回日本関節鏡・膝・スポーツ整形外科学会
- Data Source
  KAKENHI-PROJECT-19H03779
[Presentation] 変形性関節症における代謝変化の検討(会議録)2020
- Author(s)
  大橋禎史, 前田真崇, 紀平大介, 服部恭典, 岸本賢治, 横田裕, 寺部健哉, 高橋伸典, 小嶋俊久, 石黒直樹
- Organizer
  第35回日本整形外科学会基礎学術集会
- Data Source
  KAKENHI-PROJECT-19H03779
[Presentation] Raloxifene augments IL-1β expression induced by TNFα in SW9832019
- Author(s)
  西梅剛・高橋伸典
- Organizer
  Orthopaedic Research Society
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K10897
[Presentation] 滑膜肉腫様細胞株（SW982）において、MethotrexateとSiglec-9の併用によりIL-1β刺激による炎症性マーカーの発現が抑制された2019
- Author(s)
  横田裕・高橋伸典
- Organizer
  第32回日本軟骨代謝学会
- Data Source
  KAKENHI-PROJECT-16K10897
[Presentation] 滑膜様細胞株におけるcarbenoxoloneの抗炎症効果の検討2019
- Author(s)
  岸本賢治、高橋伸典
- Organizer
  日本整形外科学会基礎学術集会
- Data Source
  KAKENHI-PROJECT-19K09620
[Presentation] The potential role of metabolic reprogramming and cartilage degradation via transient receptor potentail vanilloid-42019
- Author(s)
  服部恭典・高橋伸典
- Organizer
  第32回軟骨代謝学会
- Data Source
  KAKENHI-PROJECT-16K10897
[Presentation] IL-1β存在下におけるTRPV4の軟骨破壊に対する役割の検討2019
- Author(s)
  服部恭典、高橋伸典
- Organizer
  日本整形外科学会基礎学術集会
- Data Source
  KAKENHI-PROJECT-19K09620
[Presentation] HYALURONAN SUPPRESSES THE EXPRESSION OF CATHEPSIN K INDUCED BY MECHANICAL STRESS LOADING IN A HUMAN2019
- Author(s)
  鈴木望人・高橋伸典
- Organizer
  Orthopaedic Research Society
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K10897
[Presentation] Anti-Inflammatory Effect of Carbenoxolone　in human synovial cells2019
- Author(s)
  岸本賢治・高橋伸典
- Organizer
  第32回軟骨代謝学会
- Data Source
  KAKENHI-PROJECT-16K10897
[Presentation] Exogenous hyaluronan can affect the metabolic reprogramming in articular chondrocytes treated with IL-1b2019
- Author(s)
  Yutaka Yokota, Nobunori Takahashi
- Organizer
  Annual meeting of Orthopaedic Research Society
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K09620
[Presentation] 4-methylumbelliferoneと2-deoxyglucoseの軟骨保護作用の作用機序2019
- Author(s)
  大橋禎史、高橋伸典
- Organizer
  日本整形外科学会基礎学術集会
- Data Source
  KAKENHI-PROJECT-19K09620
[Presentation] 軟骨様細胞株（HCS2/8）において、メカニカルストレスによるカテプシンKの発現亢進は高分子ヒアルロン酸により抑制する2018
- Author(s)
  鈴木望人・高橋伸典
- Organizer
  日本整形外科学会基礎学術集会
- Data Source
  KAKENHI-PROJECT-16K10897
[Presentation] 繊維芽細胞株（TIG）のスクレロスチン発現はLPS刺激で亢進し、ヒアルロン酸添加で抑制される2018
- Author(s)
  横田裕・高橋伸典
- Organizer
  第5回JCRベーシックリサーチカンファレンス
- Data Source
  KAKENHI-PROJECT-16K10897
[Presentation] Dkk1発現低下作用のある薬剤の軟骨細胞に対する効果についての検討2018
- Author(s)
  西梅剛・高橋伸典
- Organizer
  日本整形外科学会基礎学術集会
- Data Source
  KAKENHI-PROJECT-16K10897
[Presentation] ADAM10 阻害剤がウシ初代軟骨細胞において機械的ストレスによる軟骨脱分化を抑制する2017
- Author(s)
  祖父江康司,高橋伸典,石黒直樹,小嶋俊久
- Organizer
  第30回日本軟骨代謝学会
- Place of Presentation
  京都市勧業館みやこめっせ（京都府京都市）
- Year and Date
  2017-03-03
- Data Source
  KAKENHI-PROJECT-16K10897
[Presentation] ADAM10 inhibitor suppresses CD44 cleavage and chondrogenic dedifferentiation in bovine primary chondrocyte cells2017
- Author(s)
  Yasumori Sobue, Nobunori Takahashi, Naoki Ishiguro, Toshihisa Kojima
- Organizer
  The Orthopaedic Research Society 2017 Annual Meeting
- Place of Presentation
  San Diego （ＵＳＡ）
- Year and Date
  2017-03-19
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K10897
[Presentation] Development of drugs for osteoarthritis by the increasing expression of DKK-1 : Making construct of DKK-1 promoter incorporated in pGL4.10.2017
- Author(s)
  西梅剛, 高橋伸典, 小嶋俊久, 石黒　直樹, 大河原美静, 大野欣司
- Organizer
  第30回日本軟骨代謝学会.
- Data Source
  KAKENHI-PROJECT-16K15661
[Presentation] DKK-1 分子発現亢進による新規変形性関節症治療薬の開発―DKK-1promoter 領域とpGL4.10 をつないだconstruct 作成2017
- Author(s)
  西梅剛,高橋伸典,小嶋俊久,石黒直樹,大河原美静,大野欣司
- Organizer
  第30回日本軟骨代謝学会
- Place of Presentation
  京都市勧業館みやこめっせ（京都府京都市）
- Year and Date
  2017-03-03
- Data Source
  KAKENHI-PROJECT-16K10897
[Presentation] 軟骨様細胞株(HCS2/8) において、カテプシンK の発現はTRPV4 刺激により亢進する2017
- Author(s)
  鈴木望人,高橋伸典,祖父江康司,小嶋俊久,石黒直樹
- Organizer
  第30回日本軟骨代謝学会
- Place of Presentation
  京都市勧業館みやこめっせ（京都府京都市）
- Year and Date
  2017-03-03
- Data Source
  KAKENHI-PROJECT-16K10897
[Presentation] The Mechanical Stress Loading Can Induce The Fragmetation Of CD44 by increased ADAM-10 expression In A Chondrocyte Cell Line2016
- Author(s)
  小早川知範　高橋伸典　小嶋俊久　石黒直樹
- Organizer
  62nd annual meeting of Orthopaedic Research Society
- Place of Presentation
  オーランド（米国）
- Year and Date
  2016-03-05
- Data Source
  KAKENHI-PROJECT-25462366
[Presentation] Hyaluronan Inhibits TLR-4 Dependent RANKL Expression in Human Rheumatoid Arthritis Synovial Fibroblast2016
- Author(s)
  Watanabe T, Takahashi N, Ishiguro N, Kojima T
- Organizer
  第29回日本軟骨代謝学
- Place of Presentation
  広島大学（広島県広島市）
- Year and Date
  2016-02-19
- Data Source
  KAKENHI-PROJECT-26462290
[Presentation] Influence of glucocorticoids on effect of denosumab on osteoporosis in patients with Japanese rheumatoid arthritis; 12 months of followup ~a Multicenter Registry Study~2016
- Author(s)
  Y. Kanayama, Y. Hirano, N. Takahashi, S. Asai, N. Ishiguro, T. Kojima, on behalf of TBCR-BONE Study Group
- Organizer
  ＡＳＢＭＲ
- Place of Presentation
  Atlanta（ＵＳＡ）
- Year and Date
  2016-09-16
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26462290
[Presentation] PROGNOSTIC FACTORS FOR ABATACEPT RETENTION IN PATIENTS WITH RHEUMATOID ARTHRITIS IN A JAPANESE MULTICENTER REGISTRY2016
- Author(s)
  M. Hanabayashi, N. Takahashi, Y. Yokota, H. Miyake, T. Kojima, N. Ishiguro, on behalf of TBCR
- Organizer
  ＥＵＬＡＲ
- Place of Presentation
  London（ＵＫ）
- Year and Date
  2016-06-08
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26462290
[Presentation] ADAM10 inhibitor suppresses chondrogenic dedifferentiation in bovine primary chondrocyte cells2016
- Author(s)
  祖父江康司　高橋伸典　小嶋俊久　石黒直樹
- Organizer
  62nd annual meeting of Orthopaedic Research Society
- Place of Presentation
  オーランド（米国）
- Year and Date
  2016-03-05
- Data Source
  KAKENHI-PROJECT-25462366
[Presentation] INFLUENCE OF ORAL PREDNISOLONE ON EFFECT OF DENOSUMAB ON OSTEOPOROSIS IN PATIENTS WITH JAPANESE RHEUMATOID ARTHRITIS; 12 MONTHS OF FOLLOW-UP A MULTICENTER REGISTRY STUDY2016
- Author(s)
  Y. Kanayama, Y. Hirano, N. Takahashi, S. Asai, N. Ishiguro, T. Kojima, on behalf of TBCR-BONE Study Group
- Organizer
  ＥＵＬＡＲ
- Place of Presentation
  London（ＵＫ）
- Year and Date
  2016-06-08
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26462290
[Presentation] EFFICACY OF INFLIXIMAB FOR SUPPRESSING RADIOGRAPHIC PROGRESSION OF CERVICAL LESIONS IN PATIENTS WITH RHEUMATOID ARTHRITIS COMPARISON WITH METHOTREXATE; TWO YEARS OF FOLLOW-UP A MULTICENTER REGISTRY STUDY2016
- Author(s)
  Y. Kanayama, T. Kojima, Y. Hirano, N. Takahashi, Y. Yabe, N. Ishiguro, on behalf of TBCR Study Group
- Organizer
  ＥＵＬＡＲ
- Place of Presentation
  London（ＵＫ）
- Year and Date
  2016-06-08
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26462290
[Presentation] ADAM10阻害剤がウシ初代軟骨細胞において軟骨脱分化を抑制する2016
- Author(s)
  祖父江康司　高橋伸典　小嶋俊久　石黒直樹
- Organizer
  第29回軟骨代謝学会
- Place of Presentation
  広島大学広仁会館（広島県広島市）
- Year and Date
  2016-02-19
- Data Source
  KAKENHI-PROJECT-25462366
[Presentation] DRUG SURVIVAL OF GOLIMUMAB IN JAPANESE PATIENTS WITH RHEUMATOID ARTHRITIS IS INDEPENDENT OF METHOTREXATE AND PREDNISOLONE CONCOMITANCE: RESULTS FROM THE MULTICENTER BIOLOGICS REGISTRY2016
- Author(s)
  M. Hayashi, T. Kanamono, H. Matsubara, K. Kishimoto, N. Takahashi, T. Kojima, N. Ishiguro
- Organizer
  ＥＵＬＡＲ
- Place of Presentation
  London（ＵＫ）
- Year and Date
  2016-06-08
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26462290
[Presentation] RETENTION RATE OF BIOLOGIC AGENTS AFTER REMISSION INDUCED WITH AND WITHOUT CONCOMITANT GLUCOCORTICOID TREATMENT IN PATIENTS WITH RHEUMATOID ARTHRITIS: A PROPENSITY SCORE MATCHED ANALYSIS2016
- Author(s)
  S. Asai, T. Kojima, N. Takahashi, K. Funahashi, N. Ishiguro, on behalf of TBCR Study Group
- Organizer
  ＥＵＬＡＲ
- Place of Presentation
  London（ＵＫ）
- Year and Date
  2016-06-08
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26462290
[Presentation] 軟骨様細胞株（HCS2/8）において、カテプシンＫの発現はTRPV4刺激により亢進する2016
- Author(s)
  鈴木望人,高橋伸典,祖父江康司,小嶋俊久,石黒直樹
- Organizer
  第３回ベーシックリサーチカンファレンス
- Place of Presentation
  アキバホール（東京都千代田区）
- Year and Date
  2016-10-14
- Data Source
  KAKENHI-PROJECT-16K10897
[Presentation] 軟骨様細胞株(HCS-2/8)において,機械的ストレスはADAM10発現を介してCD44を断片化する2016
- Author(s)
  小早川知範　高橋伸典　小嶋俊久　石黒直樹
- Organizer
  第29回軟骨代謝学会
- Place of Presentation
  広島大学広仁会館（広島県広島市）
- Year and Date
  2016-02-19
- Data Source
  KAKENHI-PROJECT-25462366
[Presentation] DKK-1分子発現亢進による新規変形性関節症治療薬の開発－DKK-1promoter領域とpGL4.10をつないだconstract作成2016
- Author(s)
  西梅剛,高橋伸典,小嶋俊久,石黒直樹,大河原美静,大野欽司
- Organizer
  第３回ベーシックリサーチカンファレンス
- Place of Presentation
  アキバホール（東京都千代田区）
- Year and Date
  2016-10-14
- Data Source
  KAKENHI-PROJECT-16K10897
[Presentation] ＡＤＡＭ１０阻害剤がウシ初代軟骨細胞において軟骨脱分化を抑制する2016
- Author(s)
  祖父江康司,高橋伸典,小嶋俊久,石黒直樹
- Organizer
  第３回ベーシックリサーチカンファレンス
- Place of Presentation
  アキバホール（東京都千代田区）
- Year and Date
  2016-10-14
- Data Source
  KAKENHI-PROJECT-16K10897
[Presentation] THE ASSOCIATION BETWEEN METHOTREXATE USE AND EFFECTS OF TREATMENT WITH A SECOND BIOLOGIC AGENT IN RHEUMATOID ARTHRITIS2016
- Author(s)
  Y. Ogawa, T. Kojima, N. Takahashi, K. Funahashi, N. Ishiguro
- Organizer
  ＥＵＬＡＲ
- Place of Presentation
  LonDon（ＵＫ）
- Year and Date
  2016-06-08
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26462290
[Presentation] ＡＤＡＭ１０阻害剤がウシ初代軟骨細胞において軟骨脱分化を抑制する2016
- Author(s)
  祖父江康司,高橋伸典,小嶋俊久,石黒直樹
- Organizer
  第31回日本整形外科学会基礎学術集会
- Place of Presentation
  福岡国際会議場（福岡県福岡市）
- Year and Date
  2016-10-13
- Data Source
  KAKENHI-PROJECT-16K10897
[Presentation] SERO-POSITIVITY FOR RHEUMATOID FACTOR IS AN INDEPENDENT PREDICTOR FOR ACHIEVEMENT OF GOOD EULAR RESPONSE AT 24 WEEKS IN ACPA POSITIVE RHEUMATOID ARTHRITIS PATIENTS TREATED WITH ABATACEPT: RESULTS FROM JAPANESE MULTICENTER REGISTRY2016
- Author(s)
  N. Takahashi, T. Kojima, K. Funahashi, N. Ishiguro, on behalf of TBCR Study Group
- Organizer
  ＥＵＬＡＲ
- Place of Presentation
  London（ＵＫ）
- Year and Date
  2016-06-08
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26462290
[Presentation] Predictive Factors for Achieving Low Disease Activity at 52 Weeks after Switching from Tumor Necrosis Factor Inhibitors to Abatacept: Results from a Multicenter Observational Cohort Study of Japanese Patients2015
- Author(s)
  Kojima T , Takahashi N, Kaneko A, Kida D, Hirano Y, Fujibayashi T, Yabe Y, Takagi H, Oguchi T, Miyake H, Kato T, Watanabe T, Hayashi M, Shioura T, Kanayama Y, Funahashi K, Asai S, Yoshioka Y, Terabe K, Takemoto T, Asai N, Ishiguro N
- Organizer
  ACR 2015
- Place of Presentation
  San Francisco, CA, U.S.A.
- Year and Date
  2015-11-06
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26462290
[Presentation] ADAM10 inhibitor suppresses chondrogenic dedifferentiation in bovine primary chondrocyte cells2015
- Author(s)
  祖父江康司　高橋伸典　小嶋俊久　石黒直樹
- Organizer
  第2回JCRベーシックリサーチカンファレンス
- Place of Presentation
  東京大学鉄門記念講堂（東京都文京区）
- Year and Date
  2015-10-02
- Data Source
  KAKENHI-PROJECT-25462366
[Presentation] 軟骨様細胞株(HCS-2/8)において,機械的ストレスはADAM10発現を介してCD44を断片化する2015
- Author(s)
  小早川知範　高橋伸典　小嶋俊久　石黒直樹
- Organizer
  第30回日本整形外科学会基礎学術集会
- Place of Presentation
  富山国際会議場ＡＮＡクラウンプラザホテル富山市民プラザ（富山県富山市）
- Year and Date
  2015-10-22
- Data Source
  KAKENHI-PROJECT-25462366
[Presentation] 関節リウマチの骨粗鬆症に対するデノスマブの短期臨床成績～TBCR-BONEより～Tsurumai Biologics Communication Registry-BONE (TBCR-BONE)2015
- Author(s)
  平野裕司金山康秀浅井秀司高橋伸典石黒直樹小嶋俊久
- Organizer
  第17回日本骨代謝学会
- Place of Presentation
  広島国際会議場（広島県広島市）
- Year and Date
  2015-09-17
- Data Source
  KAKENHI-PROJECT-26462290
[Presentation] 軟骨様細胞株(HCS-2/8)において,機械的ストレスはADAM10発現を介してCD44を断片化する2015
- Author(s)
  小早川知範　高橋伸典　小嶋俊久　石黒直樹
- Organizer
  第2回JCRベーシックリサーチカンファレンス
- Place of Presentation
  東京大学鉄門記念講堂（東京都文京区）
- Year and Date
  2015-10-02
- Data Source
  KAKENHI-PROJECT-25462366
[Presentation] Importance of both disease activity at 12 weeks and clinical response up to 12 weeks to predict achievement of low disease activity at 52 weeks during abatacept treatment in biologics-switching patients with rheumatoid arthritis: a multicenter observational cohort study in Japan2015
- Author(s)
  Kojima T , Takahashi N, Kaneko A, Kida D, Hirano Y, Fujibayashi T, Yabe Y, Takagi H, Oguchi T, Miyake H, Kato T, Watanabe T, Hayashi M, Shioura T, Kanayama Y, Funahashi K, Asai S, Yoshioka Y, Terabe K, Takemoto T, Asai N, Ishiguro N
- Organizer
  EULAR 2015
- Place of Presentation
  Rome, Italy
- Year and Date
  2015-06-10
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26462290
[Presentation] THE SHORT-TERM EFFICACY OF DENOSUMAB IN OSTEOPOROSIS IN PATIENTS WITH RHEUMATOID ARTHRITIS FROM A JAPANESE MULTICENTER REGISTRY2015
- Author(s)
  Hirano Y, Kanayama Y, Hirabara S, Asai S, Takahashi N,　Ito T, Ishiguro N, Kojima T
- Organizer
  ASBMR2015 Annual Meeting
- Place of Presentation
  Seattle, WA, U.S.A.
- Year and Date
  2015-10-09
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26462290
[Presentation] HYALURONAN INHIBITS TLR-4 DEPENDENT RANKL EXPRESSION IN HUMAN RHEUMATOID ARTHRITIS SYNOVIAL FIBROBLASTS2015
- Author(s)
  Watanabe T, Takahashi N, Ishiguro N, Kojima T
- Organizer
  ISHAS HA 2015 Conference
- Place of Presentation
  Firenze, Italy
- Year and Date
  2015-06-07
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26462290
[Presentation] Lipophilic statins inhibit CD44 fragmentation in chondrocytes2014
- Author(s)
  寺部健哉、高橋伸典、小嶋俊久、石黒直樹
- Organizer
  Orthopedic research society annual meeting 2014
- Place of Presentation
  New Orleans, USA
- Data Source
  KAKENHI-PROJECT-25462366
[Presentation] スタチンは軟骨様細胞におけるCD44の断片化を阻害する2014
- Author(s)
  寺部健哉、高橋伸典、小嶋俊久、石黒直樹
- Organizer
  第27回日本軟骨代謝学会
- Place of Presentation
  京都府医師会館、京都市
- Data Source
  KAKENHI-PROJECT-25462366
[Presentation] スタチンは軟骨様細胞における CD44 の断片化を阻害する2013
- Author(s)
  寺部健哉、高橋伸典、小嶋俊久、石黒直樹
- Organizer
  第26回日本軟骨代謝学会
- Place of Presentation
  大阪
- Data Source
  KAKENHI-PROJECT-23791679
[Presentation] Lipophilic statins inhibit CD44 fragmentation in chondrocyte cells2013
- Author(s)
  高橋伸典
- Organizer
  59th annual meeting of Orthopaedic Research Society
- Place of Presentation
  サンアントニオ、米国
- Data Source
  KAKENHI-PROJECT-23791679
[Presentation] Lipophilic statins inhibit CD44 fragmentation in chondrocyte cells2013
- Author(s)
  Terabe K, Kojima T, Takahashi N, Ishiguro N
- Organizer
  59thannual meeting of Orthopaedic Research Society
- Place of Presentation
  San Antonio, USA
- Data Source
  KAKENHI-PROJECT-23791679
[Presentation] スタチンは軟骨様細胞におけるCD44の断片化を阻害する2013
- Author(s)
  高橋伸典
- Organizer
  第26回日本軟骨代謝学会
- Place of Presentation
  大阪、日本
- Data Source
  KAKENHI-PROJECT-23791679
[Presentation] スタチンは軟骨様細胞におけるCD44の断片化を阻害する2013
- Author(s)
  寺部健哉、高橋伸典、小嶋俊久、石黒直樹
- Organizer
  第28回日本整形外科学会基礎学術集会
- Place of Presentation
  幕張メッセ国際会議場、千葉市
- Data Source
  KAKENHI-PROJECT-25462366
[Presentation] Lipophilic statins inhibit CD44 fragmentation in chondrocytes2013
- Author(s)
  寺部健哉、高橋伸典、小嶋俊久、石黒直樹
- Organizer
  International Society for Hyaluronan Sciences 9th International Conference
- Place of Presentation
  Oklahoma city, USA
- Data Source
  KAKENHI-PROJECT-25462366
[Presentation] IMPORTANCE OF CONCOMITANT METHOTREXATE WITH TOCILIZUMAB AND ASSESSMENT OF STRUCTUAL DAMAGE FOR ACHIEVING BETTER CLINICAL OUTCOMES FOR RHEUMATOID ARTHRITIS PATIENTS WITH HIGH DISEASE ACTIVITY:AN OBSERVATIONAL COHORT STUDY
- Author(s)
  T. Kojima, N. Takahashi, K. Funahashi, S. Asai, S. Hirabara, M. Hanabayashi, Y. Yoshioka, Y. Yabe, N. Ishiguro, On behalf of Tsurumai Biologics Communication Registry (TBCR)
- Organizer
  EULAR
- Place of Presentation
  Paris,France
- Year and Date
  2014-06-11 – 2014-06-14
- Data Source
  KAKENHI-PROJECT-26462290
[Presentation] Improving of safety in treatment with biologics during first seven-years experience; Long-term results from observational cohort study of clinical paractice using multicenter registry in Japan
- Author(s)
  T. Kojima, N. Takahashi, K. Funahashi, Atsushi Kaneko, Yuji Hirano, Yuichiro Yabe,Yasuhide Kanayama,S. Asai, Y. Yoshioka, K. Terabe, T. Takemoto, N. Asai, N. Ishiguro
- Organizer
  American College of Rheumatology
- Place of Presentation
  Boston,USA
- Year and Date
  2014-11-15 – 2014-11-19
- Data Source
  KAKENHI-PROJECT-26462290

1. KOJIMA Toshihisa (70378032)

# of Collaborated Projects: 4 results

# of Collaborated Products: 51 results
2. ISHIGURO NAOKI (20212871)

# of Collaborated Projects: 4 results

# of Collaborated Products: 34 results
3. 寺部健哉 (10816870)

# of Collaborated Projects: 3 results

# of Collaborated Products: 0 results
4. YAMAMOTO Akihito (50244083)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
5. 舟橋康治 (80566977)

# of Collaborated Projects: 2 results

# of Collaborated Products: 23 results
6. 水野正明 (70283439)

# of Collaborated Projects: 2 results

# of Collaborated Products: 1 results
7. 酒井忠博 (60378198)

# of Collaborated Projects: 2 results

# of Collaborated Products: 1 results
8. 平岩秀樹 (70566976)

# of Collaborated Projects: 2 results

# of Collaborated Products: 3 results
9. 加納史也 (40801626)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
10. 橋本登 (90712365)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
11. KOJIMA Masayo (30326136)

# of Collaborated Projects: 1 results

# of Collaborated Products: 20 results
12. Suzuki Nobuaki (70637686)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
13. 浅井秀司 (00770893)

# of Collaborated Projects: 1 results

# of Collaborated Products: 11 results
14. 鬼頭浩史 (40291174)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
15. 今釜史郎 (40467288)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
16. 大野欽司 (80397455)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
17. 大河原美静 (80589606)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
18. 横田裕 (50868031)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
19. 田村彰吾 (60722626)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
20. 鈴木敦夫 (80835398)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
21. 大橋禎史 (90877044)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
22. YOSHIOKA Yutaka

# of Collaborated Projects: 1 results

# of Collaborated Products: 6 results
23. HIRABARA shinya

# of Collaborated Projects: 1 results

# of Collaborated Products: 3 results
24. HIRANO Yuji

# of Collaborated Projects: 1 results

# of Collaborated Products: 11 results
25. HAYASHI Masatoshi

# of Collaborated Projects: 1 results

# of Collaborated Products: 6 results
26. YABE Yuichiro

# of Collaborated Projects: 1 results

# of Collaborated Products: 8 results
27. OGUCHI Takeshi

# of Collaborated Projects: 1 results

# of Collaborated Products: 5 results
28. FUJIBAYASHI Takayoshi

# of Collaborated Projects: 1 results

# of Collaborated Products: 5 results
29. TAKAGI Hideki

# of Collaborated Projects: 1 results

# of Collaborated Products: 5 results
30. KANAYAMA Yasuhide

# of Collaborated Projects: 1 results

# of Collaborated Products: 11 results

Takahashi Nobunori 高橋 伸典

TAKAHASHI Nobunori 高橋 伸典

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ヒアルロン酸レセプターCD44の断片化阻害による、関節軟骨変性抑制効果Principal Investigator

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The suppressive effect on chondrocyte dedifferentiation by preventing the fragmentation of hyaluronan receptor CD44Principal Investigator

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Inhibition of CD44 cleavage suppresses the chondrocyte de-differentiationPrincipal Investigator

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Inhibition of CD44 cleavage suppresses the chondrocyte de-differentiationPrincipal Investigator

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Inhibition of CD44 cleavage suppresses the chondrocyte de-differentiationPrincipal Investigator

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[Book] 株式会社アークメディア2016

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Takahashi Nobunori 高橋伸典

TAKAHASHI Nobunori 高橋伸典