AKIYAMA TOMOHIKO 秋山智彦

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AKIYAMA Tomohiko 秋山智彦

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Researcher Number	20570691
Other IDs
Affiliation (Current)	2026: 横浜市立大学, 医学部, 助教
Affiliation (based on the past Project Information) *help	2026: 横浜市立大学, 医学部, 助教 2022 – 2024: 横浜市立大学, 医学部, 助教 2020 – 2021: 慶應義塾大学, 医学部(信濃町), 講師 2018 – 2019: 慶應義塾大学, 医学部(信濃町), 助教 2017: 慶應義塾大学, 医学部(信濃町), 特任助教 2010 – 2011: 東京大学, 大学院・新領域創成科学研究科, 特任研究員
Review Section/Research Field	Principal Investigator Basic Section 43010:Molecular biology-related / Biological Sciences / Developmental biology / Applied animal science Except Principal Investigator Developmental biology
Keywords	Principal Investigator 分化制御 / 多能性幹細胞 / 細胞分化 / ヒトES細胞 / UTX / 性染色体 / 幹細胞 / エンハンサー / 多能性 / 転写因子 … More / クロマチン / 転写制御 / ES細胞 / 分化 / クロマチン制御 / 遺伝子発現 / UTX/UTY / 自己複製 / エンハンサー複製 / プロモーター / 非ゲノム情報 / エピジェネティクス / 転写マシナリー / 性差 / エンハンサー制御 / UTY / ヒト発生 / クロマチン構造 / ヒト多能性幹細胞 / ヒストン脱メチル化酵素 / 転写調節 / 配置制御 / 転写制御因子 / 高次クロマチン構造 / 転写因子ネットワーク / シスエレメント / オープンクロマチン / ATACシーケンス / 神経分化 / 骨格筋分化 / 発生・分化 / 発生 … More Except Principal Investigator Zscan4 / マウス胚性幹細胞 / ノックアウト / マウス発生学 / 遺伝子機能解析 / テロメア伸長 / ゲノム安定化 / 若返り / 組織幹細胞 / ZSCAN4 Less

胚性ゲノム活性化におけるRNAポリメラーゼIIの一時停止解除機構の解明Principal Investigator
- Principal Investigator
  
  秋山智彦
- Project Period (FY)
  2026 – 2028
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 43010:Molecular biology-related
- Research Institution
  Yokohama City University
Maintenance and regeneration of enhancer loops involved in pluripotencyPrincipal Investigator
- Principal Investigator
  
  秋山智彦
- Project Period (FY)
  2022 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
- Review Section
  
  Biological Sciences
- Research Institution
  Yokohama City University
Elucidation of the Transcriptional Regulatory Mechanisms that Switch during ES Cell DifferentiationPrincipal Investigator
- Principal Investigator
  
  AKIYAMA Tomohiko
- Project Period (FY)
  2022 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 43010:Molecular biology-related
- Research Institution
  Yokohama City University
転写装置の性差形成機構の解明Principal Investigator
- Principal Investigator
  
  秋山智彦
- Project Period (FY)
  2020 – 2021
- Research Category
  
  Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
- Review Section
  
  Biological Sciences
- Research Institution
  Keio University
幹細胞のエンハンサー機能を支えるクロマチン継承機構Principal Investigator
- Principal Investigator
  
  秋山智彦
- Project Period (FY)
  2020 – 2021
- Research Category
  
  Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
- Review Section
  
  Biological Sciences
- Research Institution
  Keio University
The roles of histone demethylases in transcriptional process involved in cell differentiationPrincipal Investigator
- Principal Investigator
  
  Akiyama Tomohiko
- Project Period (FY)
  2019 – 2021
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 43010:Molecular biology-related
- Research Institution
  Keio University
Elucidating of transcription factor network during the differentiation of human ES cellsPrincipal Investigator
- Principal Investigator
  
  AKIYAMA TOMOHIKO
- Project Period (FY)
  2017 – 2018
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Developmental biology
- Research Institution
  Keio University
Novel molecular mechanisms for enabling the maintenance and rejuvenation of tissue stem cells
- Principal Investigator
  
  KO Minoru
- Project Period (FY)
  2017 – 2019
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Research Field
  
  Developmental biology
- Research Institution
  Keio University
Replacement of core histones in nuclear transferPrincipal Investigator
- Principal Investigator
  
  AKIYAMA Tomohiko
- Project Period (FY)
  2010 – 2011
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Applied animal science
- Research Institution
  The University of Tokyo

All 2022 2021 2020 2019 2018 2017 2011

All Journal Article Presentation Book

[Book] 生物の科学　遺伝2021
- Author(s)
  秋山智彦、中武悠樹、洪繁、小原收、的場亮、阿久津英憲、西村邦裕、洪　実
- Total Pages
  5
- Publisher
  公益財団法人遺伝学普及会
- Data Source
  KAKENHI-PUBLICLY-20H05395
[Journal Article] Purification of cardiomyocytes and neurons derived from human pluripotent stem cells by inhibition of de novo fatty acid synthesis2022
- Author(s)
  Tanosaki S, Akiyama T, Kanaami S, Fujita J, Ko SH M, Fukuda K, Tohyama* (*Corresponding author). S
- Journal Title
  
  STAR Protoc.
  
  Volume: 8 Issue: 2 Pages: 101360-101360
- DOI
  10.1016/j.xpro.2022.101360
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20H03768, KAKENHI-PROJECT-22K08925, KAKENHI-PLANNED-20H05744, KAKENHI-PUBLICLY-20H04929, KAKENHI-PUBLICLY-20H05395
[Journal Article] Meiosis-specific ZFP541 repressor complex promotes developmental progression of meiotic prophase towards completion during mouse spermatogenesis2021
- Author(s)
  Horisawa-Takada Yuki et al.
- Journal Title
  
  Nature Communications
  
  Volume: 12 Issue: 1 Pages: 3184-3184
- DOI
  10.1038/s41467-021-23378-4
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K06642, KAKENHI-PROJECT-20K21504, KAKENHI-PROJECT-20K22638, KAKENHI-PLANNED-17H06424, KAKENHI-PLANNED-19H05743, KAKENHI-PLANNED-19H05748, KAKENHI-PROJECT-21H04769, KAKENHI-PROJECT-20H03265, KAKENHI-PROJECT-21K19221, KAKENHI-PROJECT-16H06276, KAKENHI-ORGANIZER-17H06423, KAKENHI-PROJECT-21K19916, KAKENHI-PUBLICLY-20H04929, KAKENHI-PUBLICLY-20H05395, KAKENHI-PROJECT-19K06492
[Journal Article] Fatty Acid Synthesis Is Indispensable for Survival of Human Pluripotent Stem Cells2020
- Author(s)
  Sho Tanosaki, Shugo Tohyama, Jun Fujita, Hiroki Nakanishi, Takayo Ohto-Nakanishi, Tomohiko Akiyama, Yuika Morita, Yoshikazu Kishino, Marina Okada, Hidenori Tani, Yusuke Soma, Kazuaki Nakajima, Hideaki Kanazawa, Masahiro Sugimoto, Minoru S.H. Ko, Makoto Suematsu, Keiichi Fukuda
- Journal Title
  
  iScience
  
  Volume: 23 Issue: 9 Pages: 101535-101535
- DOI
  10.1016/j.isci.2020.101535
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K21608, KAKENHI-PROJECT-17K07194, KAKENHI-PLANNED-20H05743, KAKENHI-PROJECT-19K06492, KAKENHI-PUBLICLY-20H04929, KAKENHI-PUBLICLY-20H05395, KAKENHI-PROJECT-19K22626
[Journal Article] Synthetic mRNA‐based differentiation method enables early detection of Parkinson's phenotypes in neurons derived from Gaucher disease‐induced pluripotent stem cells2020
- Author(s)
  Akiyama Tomohiko（責任著者）、Sato Saeko、Ko Shigeru B. H.、Sano Osamu、Sato Sho、Saito Masayo、Nagai Hiroaki、Ko Minoru S. H.、Iwata Hidehisa
- Journal Title
  
  STEM CELLS Translational Medicine
  
  Volume: 10 Issue: 4 Pages: 572-581
- DOI
  10.1002/sctm.20-0302
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K06492, KAKENHI-PUBLICLY-20H04929, KAKENHI-PUBLICLY-20H05395
[Journal Article] Generation and Profiling of 2,135 Human ESC Lines for the Systematic Analyses of Cell States Perturbed by Inducing Single Transcription Factors2020
- Author(s)
  Nakatake Y、Ko S B.H.、Sharov A A.、Wakabayashi S、Murakami M、Sakota M、Chikazawa N、Ookura C、Sato S、Ito N、Ishikawa-Hirayama M、Mak Siu S、Jakt Lars M、Ueno T、Hiratsuka K、Matsushita M、Goparaju S K、Akiyama T、Ishiguro K、Oda M、Gouda N、Umezawa A、Akutsu H、Nishimura K、Matoba R、Ohara O、Ko M S.H.
- Journal Title
  
  Cell Reports
  
  Volume: 31 Issue: 7 Pages: 107655-107655
- DOI
  10.1016/j.celrep.2020.107655
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K08085, KAKENHI-PROJECT-18K06039, KAKENHI-PROJECT-19K06492, KAKENHI-PUBLICLY-20H04929, KAKENHI-PUBLICLY-20H05395
[Journal Article] Induction of human pluripotent stem cells into kidney tissues by synthetic mRNAs encoding transcription factors.2019
- Author(s)
  Hiratsuka K, Monkawa T, Akiyama T, Nakatake Y, Oda M, Goparaju SK, Kimura H, Chikazawa-Nohtomi N, Sato S, Ishiguro K, Yamaguchi S, Suzuki S, Morizane R, Ko SBH, Itoh H, Ko MSH
- Journal Title
  
  Scientific reports
  
  Volume: 9 Issue: 1 Pages: 913-913
- DOI
  10.1038/s41598-018-37485-8
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K08085, KAKENHI-PROJECT-18K19304, KAKENHI-PROJECT-18K15399, KAKENHI-PROJECT-17H03634, KAKENHI-PROJECT-17K15129
[Journal Article] Induced Pluripotent Stem Cells Reprogrammed with Three Inhibitors Show Accelerated Differentiation Potentials with High Levels of 2-Cell Stage Marker Expression2019
- Author(s)
  Nishihara Koji、Shiga Takahiro、Nakamura Eri、Akiyama Tomohiko、Sasaki Takashi、Suzuki Sadafumi、Ko Minoru S.H.、Tada Norihiro、Okano Hideyuki、Akamatsu Wado
- Journal Title
  
  Stem Cell Reports
  
  Volume: 12 Issue: 2 Pages: 305-318
- DOI
  10.1016/j.stemcr.2018.12.018
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PUBLICLY-17H05706, KAKENHI-PROJECT-16K09677, KAKENHI-PROJECT-26430207, KAKENHI-PROJECT-17K16130, KAKENHI-PROJECT-18K05691, KAKENHI-PROJECT-17K15129
[Journal Article] Establishment of a rapid and footprint-free protocol for differentiation of human embryonic stem cells into pancreatic endocrine cells with synthetic mRNAs encoding transcription factors2018
- Author(s)
  Ida H., Akiyama T., Ishiguro K., Goparaju SK., Nakatake Y., Chikazawa-Nohtomi N., Sato S., Kimura H., Yokoyama Y., Nagino M., Ko MSH., Ko SBH.
- Journal Title
  
  Stem Cell Res Ther.
  
  Volume: 9, 277 Issue: 1 Pages: 1-10
- DOI
  10.1186/s13287-018-1038-3
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K19304, KAKENHI-PROJECT-17H03634, KAKENHI-PROJECT-17K15129
[Journal Article] Efficient differentiation of human pluripotent stem cells into skeletal muscle cells by combining RNA-based MYOD1-expression and POU5F1-silencing.2018
- Author(s)
  Akiyama T, Sato S, Chikazawa-Nohtomi N, Soma A, Kimura H, Wakabayashi S, Ko SBH, Ko MSH.
- Journal Title
  
  Sci Rep.
  
  Volume: 8 Issue: 1 Pages: 1189-1189
- DOI
  10.1038/s41598-017-19114-y
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-15H04812, KAKENHI-PROJECT-17K15129
[Journal Article] Epigenetic manipulation facilitates the generation of skeletal muscle cells from pluripotent stem cells.2017
- Author(s)
  Tomohiko Akiyama, Shunichi Wakabayashi, Atsumi Soma, Saeko Sato, Yuhki Nakatake, Mayumi Oda, Miyako Murakami, Miki Sakota, Nana Chikazawa-Nohtomi, Shigeru B. H. Ko, Minoru S. H. Ko
- Journal Title
  
  Stem Cell International.
  
  Volume: 2017 Pages: 7215010-7215010
- DOI
  10.1155/2017/7215010
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-15K14431, KAKENHI-PROJECT-15H04812, KAKENHI-PROJECT-17K15129
[Presentation] 多能性を規定するエンハンサーループの維持と再構築機構の解明2022
- Author(s)
  秋山智彦
- Organizer
  第5回新学術領域会議
- Invited
- Data Source
  KAKENHI-PROJECT-22K06090
[Presentation] 性染色体上遺伝子UTX/UTYによるヒト分化多能性の維持機構2022
- Author(s)
  秋山智彦
- Organizer
  第74回日本細胞生物学会
- Invited
- Data Source
  KAKENHI-PROJECT-22K06090
[Presentation] ２つのヒストン脱メチル化酵素により制御される転写調節機構2021
- Author(s)
  秋山智彦
- Organizer
  熊本大学発生医学研究所
- Invited
- Data Source
  KAKENHI-PUBLICLY-20H05395
[Presentation] 多能性幹細胞における転写因子配置調節機構2021
- Author(s)
  秋山智彦
- Organizer
  日本遺伝学会
- Invited
- Data Source
  KAKENHI-PUBLICLY-20H05395
[Presentation] Corporative roles of UTX and UTY in human embryonic stem cells2021
- Author(s)
  Tomohiko Akiyama
- Organizer
  新学術領域「非ゲノム情報複製」国際Webinar
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PUBLICLY-20H05395
[Presentation] Transcriptome Manipulation to Facilitate the Differentiation of Human Pluripotent Stem Cells2018
- Author(s)
  秋山　智彦
- Organizer
  幹細胞シンポジウム
- Invited
- Data Source
  KAKENHI-PROJECT-17K15129
[Presentation] ２つのヒストン脱メチル化酵素により制御される転写調節機構2018
- Author(s)
  秋山智彦
- Organizer
  熊本大学発生医学研究所第348回発生研セミナー
- Invited
- Data Source
  KAKENHI-PROJECT-17K15129
[Presentation] マスター転写因子とヒストン脱メチル化酵素の関連性2018
- Author(s)
  秋山智彦
- Organizer
  第41回日本分子生物学会
- Invited
- Data Source
  KAKENHI-PROJECT-17K15129
[Presentation] ヒトES細胞の直接分化誘導に関わるaccessible chromatin構造2017
- Author(s)
  秋山　智彦
- Organizer
  次世代生命科学研究会
- Invited
- Data Source
  KAKENHI-PROJECT-17K15129
[Presentation] Accelerated differentiation of human pluripotent stem cells by ectopic expression of histone demethylase2017
- Author(s)
  Tomohiko Akiyama
- Organizer
  日本発生生物学会
- Invited
- Data Source
  KAKENHI-PROJECT-17K15129
[Presentation] ヒトES細胞-骨格筋変換に関わるaccessible chromatin構造2017
- Author(s)
  秋山　智彦
- Organizer
  エピジェネティクス研究会
- Data Source
  KAKENHI-PROJECT-17K15129
[Presentation] 核移植胚におけるコアヒストン置換によるクロマチンの再構築2011
- Author(s)
  秋山智彦
- Organizer
  第52回日本哺乳動物卵子学会
- Place of Presentation
  国際医療福祉大学(栃木県大田原市)
- Data Source
  KAKENHI-PROJECT-22780250
[Presentation] 核移植胚におけるコアヒストン置換によるクロマチンの再構築2011
- Author(s)
  秋山智彦・那順布和・青木不学
- Organizer
  第52回日本哺乳動物卵子学会
- Place of Presentation
  栃木県大田原市
- Data Source
  KAKENHI-PROJECT-22780250

1. KO Minoru (50631199)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
2. 中武悠樹 (20415251)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
3. 洪繁 (90402578)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
4. 小田真由美 (80567511)

# of Collaborated Projects: 1 results

# of Collaborated Products: 3 results
5. ISHIGURO Kei-ichiro

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
6. 遠山周吾

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results
7. 高田幸

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
8. 岡田麻里奈

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
9. 福田恵一

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
10. 赤松和土

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

AKIYAMA TOMOHIKO 秋山 智彦

AKIYAMA Tomohiko 秋山 智彦

Research Projects

Research Products

Co-Researchers

胚性ゲノム活性化におけるRNAポリメラーゼIIの一時停止解除機構の解明Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Maintenance and regeneration of enhancer loops involved in pluripotencyPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Elucidation of the Transcriptional Regulatory Mechanisms that Switch during ES Cell DifferentiationPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

転写装置の性差形成機構の解明Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

幹細胞のエンハンサー機能を支えるクロマチン継承機構Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

The roles of histone demethylases in transcriptional process involved in cell differentiationPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Elucidating of transcription factor network during the differentiation of human ES cellsPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Novel molecular mechanisms for enabling the maintenance and rejuvenation of tissue stem cells

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Replacement of core histones in nuclear transferPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Book] 生物の科学 遺伝2021

Author(s)

Total Pages

Publisher

Data Source

[Journal Article] Purification of cardiomyocytes and neurons derived from human pluripotent stem cells by inhibition of de novo fatty acid synthesis2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Meiosis-specific ZFP541 repressor complex promotes developmental progression of meiotic prophase towards completion during mouse spermatogenesis2021

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Fatty Acid Synthesis Is Indispensable for Survival of Human Pluripotent Stem Cells2020

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Synthetic mRNA‐based differentiation method enables early detection of Parkinson's phenotypes in neurons derived from Gaucher disease‐induced pluripotent stem cells2020

AKIYAMA TOMOHIKO 秋山智彦

AKIYAMA Tomohiko 秋山智彦

[Book] 生物の科学　遺伝2021