Yokoyama Atsushi 横山敦

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YOKOYAMA Atsushi 横山敦

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Researcher Number	20572332
Other IDs	https://orcid.org/0000-0003-2842-4334
Affiliation (Current)	2025: 東北大学, 医学系研究科, 准教授
Affiliation (based on the past Project Information) *help	2021 – 2024: 東北大学, 医学系研究科, 准教授 2016 – 2020: 東北大学, 医学系研究科, 助教 2017: 東北大学, 大学院医学系研究科, 助教 2015: 東北大学, 大学院医学系研究科, 助教 2013: 東北大学, 医学(系)研究科(研究院), 助教 … More 2012: 東京大学, 分子細胞生物学研究所, 助教 2011: 東京大学, 分子細胞生物学研究所, 特任助教 2010: 東京大学, 分子細胞生物学研究所, 特任研究員 Less
Review Section/Research Field	Principal Investigator Applied biochemistry / Basic Section 59020:Sports sciences-related / Pathological medical chemistry Except Principal Investigator Medium-sized Section 59:Sports sciences, physical education, health sciences, and related fields / Basic Section 59040:Nutrition science and health science-related / Endocrinology / Biological Sciences
Keywords	Principal Investigator 翻訳後修飾 / 核内受容体 / パイオニア因子 / 筋力増強 / 骨格筋 / アンドロゲン / 遺伝子発現制御 / 代謝異常学 / RIME / 炎症 … More / メサンギウム細胞 / ChREBP / 糖尿病性腎症 / 腎症 / 糖尿病 / 生化学 / プロテオミクス / 細胞応答 / 翻訳後修 / 遺伝子発現 … More Except Principal Investigator ChREBP / ハイスループットスクリーニング / 糖尿病性腎症 / 転写因子 / 構造最適化 / 新規創薬 / 創薬 / 化合物ライブラリー / 肝星細胞 / 肝細胞 / NASH / NAFLD / 近位尿細管 / RNAシークエンス / 糖尿病性腎臓病 / にCRISPR-Cas9法 / チオレドキシン相互作用タンパク質 / CRISPR-Cas9 / Txnip / RNAシークエンス / 酸化ストレス / TXNIP / モデルマウス / 免疫沈降法 / ChIPアッセイ / CRISPR-Cas9システム / 肥満 / ゲノム編集 / CYP11B2 / 高血圧 / VIKING法 / 質量分析 / アルドステロン / イオン交換クロマトグラフィー / 治療抵抗性高血圧 / メタボリック症候群 / 脂肪細胞 / アルドステロン合成酵素 / スクリーニング / 糖質応答転写因子 / CRISPR/Cas9システム / トランスジェニック / 性差 / 卵巣 / 性特異的エンハンサー / 性差構築 / 発生・分化 / 発現制御 / セルトリ細胞 / ライディッヒ細胞 / 精巣 / クロマチン構造 / 遺伝子発現 / 発生 / ゲノム Less

糖質応答転写因子ChREBPの新規阻害薬を用いた糖尿病性腎臓病の病態解明・制御
- Principal Investigator
  
  菅原明
- Project Period (FY)
  2024 – 2026
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 59040:Nutrition science and health science-related
- Research Institution
  Tohoku University
新規ChREBP阻害薬の標的遺伝子に対するPerturbシークエンスを用いたNAFLDの病態制御
- Principal Investigator
  
  菅原明
- Project Period (FY)
  2024 – 2025
- Research Category
  
  Grant-in-Aid for Challenging Research (Exploratory)
- Review Section
  
  Medium-sized Section 59:Sports sciences, physical education, health sciences, and related fields
- Research Institution
  Tohoku University
Identification and analysis of a pioneer factor for androgen receptor in skeletal musclePrincipal Investigator
- Principal Investigator
  
  Yokoyama Atsushi
- Project Period (FY)
  2021 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 59020:Sports sciences-related
- Research Institution
  Tohoku University
Innovation of novel therapeutics against diabetic nephropathy
- Principal Investigator
  
  Sugawara Akira
- Project Period (FY)
  2021 – 2022
- Research Category
  
  Grant-in-Aid for Challenging Research (Exploratory)
- Review Section
  
  Medium-sized Section 59:Sports sciences, physical education, health sciences, and related fields
- Research Institution
  Tohoku University
Innovation of a novel DN medication by targeting ChREBP
- Principal Investigator
  
  Sugawara Akira
- Project Period (FY)
  2020 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 59040:Nutrition science and health science-related
- Research Institution
  Tohoku University
Identification of a novel adipocyte-derived factor that elevates blood pressure using VIKING method
- Principal Investigator
  
  Sugawara Akira
- Project Period (FY)
  2019 – 2020
- Research Category
  
  Grant-in-Aid for Challenging Research (Exploratory)
- Review Section
  
  Medium-sized Section 59:Sports sciences, physical education, health sciences, and related fields
- Research Institution
  Tohoku University
Screening of drug target proteins for diabetic nephropathy by identification of ChREBP complex from renal mesangial cellsPrincipal Investigator
- Principal Investigator
  
  Yokoyama Atsushi
- Project Period (FY)
  2016 – 2018
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Pathological medical chemistry
- Research Institution
  Tohoku University
Innovation of novel therapeutics against diabetic nephropathy targeting ChREBP
- Principal Investigator
  
  Sugawara Akira
- Project Period (FY)
  2016 – 2017
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Endocrinology
- Research Institution
  Tohoku University
Identification of novel PTMsPrincipal Investigator
- Principal Investigator
  
  YOKOYAMA Atsushi
- Project Period (FY)
  2012 – 2013
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Applied biochemistry
- Research Institution
  Tohoku University
  The University of Tokyo
Analysis of nuclear lipidation in gene regulationPrincipal Investigator
- Principal Investigator
  
  YOKOYAMA Atsushi
- Project Period (FY)
  2010 – 2011
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Applied biochemistry
- Research Institution
  The University of Tokyo
Establishment of sex differences through sex-specific enhancer
- Principal Investigator
  
  MOROHASHI Ken-ichirou
- Project Period (FY)
  2010 – 2015
- Research Category
  
  Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
- Review Section
  
  Biological Sciences
- Research Institution
  Kyushu University

[Book] 細胞内発現タンパク質の精製と解析2010
- Author(s)
  横山敦、加藤茂明
- Total Pages
  4
- Publisher
  メディカルバイオ(オーム社)、11月号
- Data Source
  KAKENHI-PROJECT-22780086
[Journal Article] ESS2 controls prostate cancer progression through recruitment of chromodomain helicase DNA binding protein 1.2023
- Author(s)
  Takahashi S,* Takada I, Hashimoto K, Yokoyama A, Nakagawa T, Makishima M, Kume H.
- Journal Title
  
  Sci Rep.
  
  Volume: 13 Issue: 1 Pages: 12355-12355
- DOI
  10.1038/s41598-023-39626-0
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-22K09442, KAKENHI-PROJECT-21K11439
[Journal Article] ステロイドホルモン研究における組織学的アプローチ2023
- Author(s)
  鈴木貴、山﨑有人、岩渕英里奈、横山敦、高木清司、三木康宏
- Journal Title
  
  第48回組織細胞化学講習会 2023
  
  Volume: 48 Pages: 197-206
- Data Source
  KAKENHI-PROJECT-21K11439
[Journal Article] 新たなアンドロゲン受容体制御因子を求めて2023
- Author(s)
  横山敦、纐纈拓海、菅原明
- Journal Title
  
  日本アンドロロジー学会ニュースレター
  
  Volume: 26 Pages: 3-5
- Data Source
  KAKENHI-PROJECT-21K11439
[Journal Article] Primary aldosteronism and obstructive sleep apnea: the strong ties between them2023
- Author(s)
  Sugawara Akira、Shimada Hiroki、Otsubo Yuri、Kouketsu Takumi、Yokoyama Atsushi
- Journal Title
  
  Hypertension Research
  
  Volume: 46 Issue: 7 Pages: 1712-1713
- DOI
  10.1038/s41440-023-01303-0
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21K11439
[Journal Article] Transcriptional coregulator Ess2 controls survival of post-thymic CD4+ T cells through the Myc and IL-7 signaling pathways2022
- Author(s)
  Takada Ichiro、Hidano Shinya、Takahashi Sayuri、Yanaka Kaori、Ogawa Hidesato、Tsuchiya Megumi、Yokoyama Atsushi、Sato Shingo、Ochi Hiroki、Nakagawa Tohru、Kobayashi Takashi、Nakagawa Shinichi、Makishima Makoto
- Journal Title
  
  Journal of Biological Chemistry
  
  Volume: 298 Issue: 9 Pages: 102342-102342
- DOI
  10.1016/j.jbc.2022.102342
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-21K07984, KAKENHI-PROJECT-21K11439, KAKENHI-PROJECT-22K06082, KAKENHI-PROJECT-21K19556, KAKENHI-PROJECT-20K07029, KAKENHI-PROJECT-17H04649, KAKENHI-PROJECT-23K24455
[Journal Article] IRF2BP2 is a novel HNF4α co-repressor: Its role in gluconeogenic gene regulation via biochemically labile interaction2022
- Author(s)
  Kouketsu Takumi、Monma Rina、Miyairi Yuri、Sawatsubashi Shun、Shima Hiroki、Igarashi Kazuhiko、Sugawara Akira、Yokoyama Atsushi
- Journal Title
  
  Biochemical and Biophysical Research Communications
  
  Volume: 615 Pages: 81-87
- DOI
  10.1016/j.bbrc.2022.04.133
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-21K11439, KAKENHI-PROJECT-20H04099, KAKENHI-PROJECT-20K07321, KAKENHI-PROJECT-21K19692
[Journal Article] YM750, an ACAT Inhibitor, Acts on Adrenocortical Cells to Inhibit Aldosterone Secretion Due to Depolarization2022
- Author(s)
  Shimada Hiroki、Hata Shuko、Yamazaki Yuto、Otsubo Yuri、Sato Ikuko、Ise Kazue、Yokoyama Atsushi、Suzuki Takashi、Sasano Hironobu、Sugawara Akira、Nakamura Yasuhiro
- Journal Title
  
  International Journal of Molecular Sciences
  
  Volume: 23 Issue: 21 Pages: 12803-12803
- DOI
  10.3390/ijms232112803
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-21K11439, KAKENHI-PROJECT-22K16406, KAKENHI-PROJECT-20H04099, KAKENHI-PROJECT-21K19692
[Journal Article] The physiological and pathophysiological roles of carbohydrate response element binding protein in the kidney2022
- Author(s)
  Yokoyama Atsushi、Suzuki Susumu、Okamoto Koji、Sugawara Akira
- Journal Title
  
  Endocr J
  
  Volume: 69 Issue: 6 Pages: 605-612
- DOI
  10.1507/endocrj.EJ22-0083
- ISSN
  0918-8959, 1348-4540
- Language
  English
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-21K11439, KAKENHI-PROJECT-20H04099, KAKENHI-PROJECT-21K19692
[Journal Article] The usefulness of angiotensin-(1-7) and des-Arg9-bradykinin as novel biomarkers for metabolic syndrome.2021
- Author(s)
  Sugawara A, Shimada H, Otsubo Y, Kouketsu T, Suzuki S, Yokoyama A.
- Journal Title
  
  Hypertens Res.
  
  Volume: 44 Issue: 8 Pages: 1034-1036
- DOI
  10.1038/s41440-021-00671-9
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20H04099, KAKENHI-PROJECT-21K19692
[Journal Article] Comparative proteomic analysis to identify the novel target gene of angiotensin II in adrenocortical H295R cells2021
- Author(s)
  Ito Ryo、Shima Hiroki、Masuda Koji、Sato Ikuko、Shimada Hiroki、Yokoyama Atsushi、Shirahige Katsuhiko、Igarashi Kazuhiko、Sugawara Akira
- Journal Title
  
  Endocr J
  
  Volume: 68 Issue: 4 Pages: 441-450
- DOI
  10.1507/endocrj.EJ20-0144
- NAID
  130008030764
- ISSN
  0918-8959, 1348-4540
- Language
  English
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K07321, KAKENHI-PROJECT-20H04099, KAKENHI-PROJECT-19K22793, KAKENHI-PROJECT-21K19692, KAKENHI-PROJECT-19K17952
[Journal Article] Identification and Functional Characterization of a Novel Androgen Receptor Coregulator, EAP12021
- Author(s)
  Yokoyama Atsushi、Kouketsu Takumi、Otsubo Yuri、Noro Erika、Sawatsubashi Shun、Shima Hiroki、Satoh Ikuro、Kawamura Sadafumi、Suzuki Takashi、Igarashi Kazuhiko、Sugawara Akira
- Journal Title
  
  Journal of the Endocrine Society
  
  Volume: 5 Issue: 11
- DOI
  10.1210/jendso/bvab150
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K09065, KAKENHI-PROJECT-20H04099, KAKENHI-PROJECT-20K07321, KAKENHI-PROJECT-21K11439, KAKENHI-PROJECT-21K19692
[Journal Article] Myofiber androgen receptor increases muscle strength mediated by a skeletal muscle splicing variant of Mylk42021
- Author(s)
  Iori Sakakibara, Yuta Yanagihara, Koichi Himori, Takashi Yamada, Hiroshi Sakai, Yuichiro Sawada, Hirotaka Takahashi, Noritaka Saeki, Hiroyuki Hirakawa, Atsushi Yokoyama, So-Ichiro Fukada, Tatsuya Sawasaki, Yuuki Imai
- Journal Title
  
  iScience
  
  Volume: 24 Issue: 4 Pages: 102303-102303
- DOI
  10.1016/j.isci.2021.102303
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20J01754, KAKENHI-PROJECT-19K19947, KAKENHI-PUBLICLY-21H00287, KAKENHI-PROJECT-20K06611, KAKENHI-PROJECT-21K05974, KAKENHI-PROJECT-21K11439, KAKENHI-PROJECT-21K19230, KAKENHI-PROJECT-21K19723, KAKENHI-PROJECT-21K17568, KAKENHI-PROJECT-23K21587
[Journal Article] The establishment of a novel high-throughput screening system using RNA-guided genome editing to identify chemicals that suppress aldosterone synthase expression2020
- Author(s)
  Ito R, Morita M, Nakano T, Sato I, Yokoyama A, Sugawara A
- Journal Title
  
  Biochem Biophys Res Commun
  
  Volume: 534 Pages: 672-679
- DOI
  10.1016/j.bbrc.2020.11.020
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19K07341, KAKENHI-PROJECT-20H04099, KAKENHI-PROJECT-19K22793, KAKENHI-PROJECT-19K17952
[Journal Article] Expression and pathophysiological significance of carbohydrate response element binding protein (ChREBP) in the renal tubules of diabetic kidney2020
- Author(s)
  Suzuki Susumu、Yokoyama Atsushi、Noro Erika、Aoki Satoshi、Shimizu Kyoko、Shimada Hiroki、Sugawara Akira
- Journal Title
  
  Endocr J
  
  Volume: 67 Issue: 3 Pages: 335-345
- DOI
  10.1507/endocrj.EJ19-0133
- NAID
  130007821346
- ISSN
  0918-8959, 1348-4540
- Language
  English
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20H04099, KAKENHI-PROJECT-19K22793
[Journal Article] Effects of Adipocyte-derived Factors on the Adrenal Cortex.2020
- Author(s)
  Shimada H, Noro E, Suzuki S, Sakamoto J, Sato I, Parvin R, Yokoyama A, Sugawara A
- Journal Title
  
  Curr Mol Pharmacol..
  
  Volume: 13(1) Issue: 1 Pages: 2-6
- DOI
  10.2174/1874467212666191015161334
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K22793, KAKENHI-PROJECT-18J11985, KAKENHI-PROJECT-20H04099
[Journal Article] Partial proteasomal degradation of Lola triggers the male-to-female switch of a dimorphic courtship circuit.2019
- Author(s)
  Kosei Sato, Hiroki Ito, Atsushi Yokoyama, Gakuta Toba and Daisuke Yamamoto
- Journal Title
  
  Nature Communications
  
  Volume: 10 Issue: 1 Pages: 166-166
- DOI
  10.1038/s41467-018-08146-1
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K07040, KAKENHI-PUBLICLY-17H05935, KAKENHI-PROJECT-16H06371, KAKENHI-PROJECT-16K08606, KAKENHI-PROJECT-17K19371
[Journal Article] Transglutaminase-mediated cross-linking of WDR54 regulates EGF receptor-signaling.2019
- Author(s)
  Maeda A, Nishino T, Matsuzaki R, Yokoyama A, Suga H, Yagi T, Konishi H.
- Journal Title
  
  Biochim Biophys Acta Mol Cell Res.
  
  Volume: 1866 Issue: 2 Pages: 285-295
- DOI
  10.1016/j.bbamcr.2018.11.009
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K07341, KAKENHI-PROJECT-16K08606, KAKENHI-PROJECT-16H06276
[Journal Article] Inhibitory effects of a novel PPAR-gamma agonist MEKT1 on Pomc expression/ACTH secretion in AtT20 cells2018
- Author(s)
  Parvin R, Noro E, Saito-Hakoda A, Shimada H, Suzuki S, Shimizu K, Miyachi H, Yokoyama A, Sugawara A.
- Journal Title
  
  PPAR Res
  
  Volume: 2018 Pages: 1-16
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-16K08606
[Journal Article] Inhibitory Effects of a Novel PPAR-γ Agonist MEKT1 on Pomc Expression/ACTH Secretion in AtT20 Cells.2018
- Author(s)
  Parvin R, Noro E, Saito-Hakoda A, Shimada H, Suzuki S, Shimizu K, Miyachi H, Yokoyama A, Sugawara A
- Journal Title
  
  PPAR Res
  
  Volume: 2018 Pages: 5346272-5346272
- DOI
  10.1155/2018/5346272
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-16H03252, KAKENHI-PROJECT-16K08606
[Journal Article] The reduction of heparan sulphate in the glomerular basement membrane does not augment urinary albumin excretion2018
- Author(s)
  Satoshi Aoki, Akiko Saito-Hakoda, Takeo Yoshikawa, Kyoko Shimizu, Kiyomi Kisu, Susumu Suzuki, Kiyoshi Takagi, Shuji Mizumoto, Shuhei Yamada, Toin H. van Kuppevelt, Atsushi Yokoyama, Taiji Matsusaka, Hiroshi Sato, Sadayoshi Ito, and Akira Sugawara
- Journal Title
  
  Nephrology Dialysis Transplantation
  
  Volume: 33 Issue: 1 Pages: 26-33
- DOI
  10.1093/ndt/gfx218
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K08251, KAKENHI-PROJECT-16K08606, KAKENHI-PROJECT-16K08645, KAKENHI-PROJECT-15K07951, KAKENHI-PROJECT-15K09420, KAKENHI-PROJECT-16K15492, KAKENHI-PROJECT-16H03252
[Journal Article] Endogenous Purification of NR4A2 (Nurr1) Identified Poly(ADP-Ribose) Polymerase 1 as a Prime Coregulator in Human Adrenocortical H295R Cells.2018
- Author(s)
  Noro, E., Yokoyama, A., Kobayashi, M., Shimada, H., Suzuki, S., Hosokawa, M., Takehara, T., Parvin, R., Shima, H., Igarashi, K. and Sugawara A.
- Journal Title
  
  International Journal of Molecular Sciences
  
  Volume: 19 Issue: 5 Pages: 1406-1406
- DOI
  10.3390/ijms19051406
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18H04021, KAKENHI-PROJECT-16H03252, KAKENHI-PROJECT-16K08606
[Journal Article] Role of NeuroD1 on the negative regulation of Pomc expression by glucocorticoid.2017
- Author(s)
  Parvin R, Saito-Hakoda A, Shimada H, Shimizu K, Noro E, Iwasaki Y, Fujiwara K, Yokoyama A, Sugawara A.
- Journal Title
  
  PLoS One.
  
  Volume: 12(4) Issue: 4 Pages: e0175435-e0175435
- DOI
  10.1371/journal.pone.0175435
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16H03252, KAKENHI-PROJECT-15K09420, KAKENHI-PROJECT-16K15492
[Journal Article] A ubiquitin-proteasome inhibitor bortezomib suppresses the expression of CYP11B2, a key enzyme of aldosterone synthesis2017
- Author(s)
  Ito Ryo、Sato Ikuko、Tsujita Tadayuki、Yokoyama Atsushi、Sugawara Akira
- Journal Title
  
  Biochem Biophys Res Commun
  
  Volume: 489 Issue: 1 Pages: 21-28
- DOI
  10.1016/j.bbrc.2017.05.109
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-16K08606, KAKENHI-PROJECT-17K19916, KAKENHI-PROJECT-16H05922, KAKENHI-PROJECT-16K19550
[Journal Article] Suppressive effects of RXR agonist PA024 on adrenal CYP11B2 expression, aldosterone secretion and blood pressure2017
- Author(s)
  Suzuki Dai、Saito-Hakoda Akiko、Ito Ryo、Shimizu Kyoko、Parvin Rehana、Shimada Hiroki、Noro Erika、Suzuki Susumu、Fujiwara Ikuma、Kagechika Hiroyuki、Rainey William E.、Kure Shigeo、Ito Sadayoshi、Yokoyama Atsushi、Sugawara Akira
- Journal Title
  
  PLoS One
  
  Volume: 12 Issue: 8 Pages: e0181055-e0181055
- DOI
  10.1371/journal.pone.0181055
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K08606, KAKENHI-PROJECT-16H03252, KAKENHI-PROJECT-15K09420, KAKENHI-PROJECT-16K15492, KAKENHI-PROJECT-16K19550
[Journal Article] Biochemical Analysis of Histone Succinylation2017
- Author(s)
  Yokoyama Atsushi、Katsura Shogo、Sugawara Akira
- Journal Title
  
  Biochem Res Int
  
  Volume: 2017 Pages: 1-7
- DOI
  10.1155/2017/8529404
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-16K08606
[Journal Article] ２)Role of NeuroD1 on the Negative Regulation of Pomc Expression by Glucocorticoid.2017
- Author(s)
  Parvin R, Saito-Hakoda A, Shimada H, Shimizu K, Noro E, Iwasaki Y, Fujii K, Yokoyama A, Sugawara A.
- Journal Title
  
  PLoS One
  
  Volume: 印刷中
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-16K08606
[Journal Article] High glucose stimulates expression of aldosterone synthase (CYP11B2) and secretion of aldosterone in human adrenal cells2017
- Author(s)
  Shimada Hiroki、Kogure Naotaka、Noro Erika、Kudo Masataka、Sugawara Kaori、Sato Ikuko、Shimizu Kyoko、Kobayashi Makoto、Suzuki Dai、Parvin Rehana、Saito-Ito Takako、Uruno Akira、Saito-Hakoda Akiko、Rainey William E.、Ito Sadayoshi、Yokoyama Atsushi、Sugawara Akira
- Journal Title
  
  FEBS Open Bio
  
  Volume: 7 Issue: 9 Pages: 1410-1421
- DOI
  10.1002/2211-5463.12277
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K08606, KAKENHI-PROJECT-16K09600, KAKENHI-PROJECT-17K01837, KAKENHI-PROJECT-16H03252, KAKENHI-PROJECT-15K09420, KAKENHI-PROJECT-16K15492
[Journal Article] Is heparan sulfate in the glomerular basement membrane necessary for the etiology of diabetic nephropathy2014
- Author(s)
  Saito-Hakoda A, Kogure N, Yoshikawa T, Shimizu K, Iki Y, Sato I, Kudo M, Uruno A, Matsuda K, Parvin R, Sugawara K, Yokoyama A, Ito S, Sugawara A
- Journal Title
  
  J Biomol Res Ther
  
  Volume: vol.3 Issue: 02
- DOI
  10.4172/2167-7956.1000e127
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24658091
[Journal Article] Identification of myelin transcription factor 1 (MyT1) as a subunit of the neural cell type-specific lysine-specific demethylase 1 (LSD1) complex.2014
- Author(s)
  Yokoyama A, Igarashi K, Sato T, Takagi K, Otsuka I M, Shishido Y, Baba T, Ito R, Kanno J, Ohkawa Y, Morohashi K, Sugawara A.
- Journal Title
  
  J Biol Chem.
  
  Volume: 289 Issue: 26 Pages: 18152-18162
- DOI
  10.1074/jbc.m114.566448
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-25281028, KAKENHI-PROJECT-25461381, KAKENHI-PROJECT-26860229, KAKENHI-PLANNED-22132002
[Journal Article] TET3-OGT interaction increases the stability and the presence of OGT in chromatin.2014
- Author(s)
  伊藤亮、桂章吾、島田洋樹、土屋光、羽田政司、奥村知子、菅原明、横山敦
- Journal Title
  
  Genes to Cells
  
  Volume: 19 Issue: 1 Pages: 52-65
- DOI
  10.1111/gtc.12107
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-13J07784, KAKENHI-PROJECT-14J10178, KAKENHI-PROJECT-24658091
[Journal Article] ARB affects nicotine-induced gene expression profile in human coronary artery endothelial cells.2014
- Author(s)
  Kudo M, Matsuda K, Sugawara K, Iki Y, Kogure N, Saito-Ito T, Shimizu K, Sato I, Yoshikawa T, Uruno A, Yokoyama A, Saito-Hakoda A, Ito S, Sugawara A.
- Journal Title
  
  World Journal of Hypertension.
  
  Volume: 4(1) Issue: 1 Pages: 7-14
- DOI
  10.5494/wjh.v4.i1.7
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24658091, KAKENHI-PROJECT-24790306
[Journal Article] Angiotensin II receptor blockers differentially affect CYP11B2 expression in human adrenal H295R cells.2014
- Author(s)
  Matsuda K, Uruno A, Kogure N, Sugawara K, Shimada H, Nezu M, Saito-Ito T, Iki Y, Kudo M, Shimizu K, Sato I, Yoshikawa T, Satoh F, Ito R, Yokoyama A, Rainey WE, Saito-Hakoda A, Ito S, Sugawara A.
- Journal Title
  
  Mol Cell Endocrinol.
  
  Volume: 383(1-2) Issue: 1-2 Pages: 60-68
- DOI
  10.1016/j.mce.2013.12.004
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24658091, KAKENHI-PROJECT-24790306, KAKENHI-PROJECT-25461381, KAKENHI-PROJECT-26460383
[Journal Article] The androgen receptor in health and disease2013
- Author(s)
  Matsumoto T, Sakari M, Okada M, Yokoyama A, Takahashi S, Kouzmenko A, Kato S
- Journal Title
  
  Annu Rev Physiol
  
  Volume: vol. 75 Issue: 1 Pages: 201-224
- DOI
  10.1146/annurev-physiol-030212-183656
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24658091, KAKENHI-PROJECT-24659715
[Journal Article] JMJD5, a Jumonji C(JmjC) domain-containing protein, negatively regulates osteoclastogenesis by facilitating NFATc1 protein degradation2012
- Author(s)
  Youn, M.-Y., Imai, Y., et al.
- Journal Title
  
  J Biol Chem
  
  Volume: 287 Issue: 16 Pages: 12994-13004
- DOI
  10.1074/jbc.m111.323105
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-11F01111, KAKENHI-PROJECT-22780086, KAKENHI-PROJECT-23658087, KAKENHI-PROJECT-23659712, KAKENHI-PROJECT-23689066, KAKENHI-PROJECT-24590346, KAKENHI-PROJECT-24658091
[Journal Article] Regulated histone methyltransferase and demethylase complexes in gene regulation by nuclear receptor2011
- Author(s)
  Yokoyama A, Fujiki R, Ohtake F, Kato S
- Journal Title
  
  Cold Spring Harb Symp Quant Biol
  
  Volume: (印刷中) Issue: 0 Pages: 165-173
- DOI
  10.1101/sqb.2011.76.010736
- Year and Date
  2011-01-01
- Data Source
  KAKENHI-PROJECT-22780086
[Journal Article] Multiple post-translational modifications in Hepatocyte nuclear factor 4α2011
- Author(s)
  Yokoyama A, Katsura S, Ito R, Hashiba W, Sekine H, Fujiki R and Kato S
- Journal Title
  
  Biochem Biophys Res Commun
  
  Volume: vol.410, No.4 Pages: 749-753
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22780086
[Journal Article] Regulated histone methyltransferase and demethylase complexes in gene regulation by nuclear receptor2011
- Author(s)
  Yokoyama A, Fujiki R, Ohtake F and Kato S
- Journal Title
  
  Cold Spring Harb Symp Quant Biol
  
  Volume: vol.76
- Data Source
  KAKENHI-PROJECT-22780086
[Journal Article] Multiple post-translational modifications in Hepatocyte nuclear factor 4α2011
- Author(s)
  Yokoyama A. Katsura S, Ito R, Hashiba W, Sekine H, Fujiki R, Kato S
- Journal Title
  
  Biochem Biophys Res Commun
  
  Volume: 410 Issue: 4 Pages: 749-753
- DOI
  10.1016/j.bbrc.2011.06.033
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22780086
[Journal Article] Zinc finger protein 467 is a novel regulator of osteoblast and adipocyte commitment.2011
- Author(s)
  Quach JM, Walker EC, Allan E, Solano M, Yokoyama A, Kato S, Sims NA, Gillespie MT, Martin TJ.
- Journal Title
  
  J Biol Chem.
  
  Volume: 286(6) Pages: 4186-4198
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22780086
[Journal Article] GlcNAcylation of histone H2B facilitates its monoubiquitination2011
- Author(s)
  Fujiki R, Hashiba W, Sekine H, Yokoyama A, Chikanishi T, Ito S, Imai Y, Kim J, He HH, Igarashi K, Kanno J, Ohtake F, Kitagawa H, Roeder RG, Brown M, Kato S
- Journal Title
  
  Nature
  
  Volume: 480(7378) Issue: 7378 Pages: 557-560
- DOI
  10.1038/nature10656
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-10J04044, KAKENHI-PUBLICLY-22121502, KAKENHI-PROJECT-22780086, KAKENHI-PROJECT-23659712, KAKENHI-PROJECT-23689066
[Journal Article] Nuclear receptor coregulators merge transcriptional coregulation with epigenetic regulation.2011
- Author(s)
  Kato S, Yokoyama A, Fujiki R
- Journal Title
  
  Trends Biochem Sci.
  
  Volume: (印刷中)(掲載確定)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22780086
[Journal Article] O-GlcNAcylation of histone H2B facilitates its monoubiquitination2011
- Author(s)
  Fujiki R, Hashiba W, Sekine H, Yokoyama A, Chikanishi T, Ito S, Imai Y, Ohtake F, Kitagawa H, Kim J, Roeder RG, He HH, Brown M and Kato S
- Journal Title
  
  Nature
  
  Volume: vol.480, No.7378 Pages: 557-560
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22780086
[Journal Article] KIAA1718 is a histone demethylase that erases repressive histone methyl marks.2010
- Author(s)
  Yokoyama A, Okuno Y, Chikanishi T, Hashiba W, Sekine H, Fujiki R, Kato S.
- Journal Title
  
  Genes Cells.
  
  Volume: 15(8) Pages: 867-873
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22780086
[Journal Article] Production and characterization of monoclonal antibodies to germ cells2010
- Author(s)
  Yokoyama C, et al.
- Journal Title
  
  Hybridoma
  
  Volume: 29 Pages: 53-57
- Peer Reviewed
- Data Source
  KAKENHI-PLANNED-22132002
[Journal Article] Identification of myelin transcription factor 1 (Myt1) as a Subunit of the Neural Cell Type-specific Lysine-specific demethylase 1 (LSD1) Complex
- Author(s)
  Yokoyama A, Igarashi K, Sato T, Takagi K, Otsuka I. M, Shishido Y, Baba T, Ito I, Kanno J, Ohkawa Y, Morohashi K, Sugawara A
- Journal Title
  
  J Biol Chem
  
  Volume: (in press)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24658091
[Journal Article] Jmj C-domain-containing protein, negatively regulates osteoclastogenesis through facilitating NFATc1 protein degradation
- Author(s)
  Youn MY, Yokoyama A, Fujiyama-Nakamura S, Ohtake F, Minehata KI, Yasuda H, Suzuki T, Kato S, Imai Y
- Journal Title
  
  J Biol Chem
  
  Volume: (in press)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22780086
[Journal Article] Identification of Post-translational Modifications in Peroxisome Proliferator-activated Receptor gamma Using Mass Spectrometry
- Author(s)
  Katsura S, Okumura T, Ito R, Sugawara A, Yokoyama A
- Journal Title
  
  PPAR Res
  
  Volume: (in press)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24658091
[Journal Article] Retinoic acid receptor-αup-regulates proopiomelanocortin gene expression in AtT20 corticotroph cells
- Author(s)
  Uruno A, Saito-Hakoda A, Yokoyama A, Kogure N, Matsuda K, Parvin R, Shimizu K, Sato I, Kudo M, Yoshikawa T, Kagechika H, Iwasaki Y, Ito S, Sugawara A
- Journal Title
  
  Endocr J
  
  Volume: (in press)
- NAID
  130004677954
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24658091
[Patent] 1,3-ジオキソラン誘導体2020
- Inventor(s)
  菅原　明、横山　敦、鈴木　歩、岩渕　好治、土井　隆行
- Industrial Property Rights Holder
  菅原　明、横山　敦、鈴木　歩、岩渕　好治、土井　隆行
- Industrial Property Rights Type
  特許
- Filing Date
  2020
- Overseas
- Data Source
  KAKENHI-PROJECT-19K22793
[Patent] 1,3-ジオキソラン誘導体2020
- Inventor(s)
  菅原　明、横山　敦、鈴木　歩、岩渕　好治、土井　隆行
- Industrial Property Rights Holder
  菅原　明、横山　敦、鈴木　歩、岩渕　好治、土井　隆行
- Industrial Property Rights Type
  特許
- Filing Date
  2020
- Overseas
- Data Source
  KAKENHI-PROJECT-20H04099
[Patent] １，３ージオキソラン誘導体2019
- Inventor(s)
  菅原明、横山敦、鈴木歩、岩渕好治、土井隆行
- Industrial Property Rights Holder
  菅原明、横山敦、鈴木歩、岩渕好治、土井隆行
- Industrial Property Rights Type
  特許
- Industrial Property Number
  2019-025963
- Filing Date
  2019
- Data Source
  KAKENHI-PROJECT-16K08606
[Presentation] CYP11B2 と KCNJ5 変異体を標的とした原発性アルドステロン症の新規創薬2023
- Author(s)
  尾坪優李、島田洋樹、横山敦、中村保宏、菅原明
- Organizer
  第45回日本高血圧学会総会
- Data Source
  KAKENHI-PROJECT-21K11439
[Presentation] 糖新生経路を標的とした新規糖尿病創薬の試み2023
- Author(s)
  氏家凌子、大内俊寛、末松渉、纐纈拓海、土井隆行、堤良平、斎藤芳郎、横山敦、菅原明
- Organizer
  第45回日本内分泌学会東北地方会
- Data Source
  KAKENHI-PROJECT-21K11439
[Presentation] タバコによるアンドロゲン受容体制御メカニズムの解析2023
- Author(s)
  阿部優香、横山　敦、小林　研太郎、菅原　明
- Organizer
  日本内分泌学会学術総会
- Data Source
  KAKENHI-PROJECT-21K11439
[Presentation] 炎症シグナルによるグルコース応答性転写因子ChREBPの機能制御メカニズムの解明2023
- Author(s)
  横山　敦、野呂　英理香、岡本好司、松澤拓郎、吉川雄朗、島弘季、五十嵐　和彦、菅原　明
- Organizer
  第41回日本内分泌学会内分泌代謝学サマーセミナー
- Data Source
  KAKENHI-PROJECT-21K11439
[Presentation] Examination of the effectiveness of diabetic nephropathy treatment targeting ChREBP activity2022
- Author(s)
  Suzuki S, Yokoyama A, Okamoto K, Iwabuchi Y, Sugawara A.
- Organizer
  アメリカ内分泌学会
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20H04099
[Presentation] 炎症シグナルによるグルコース応答性転写因子ChREBPの機能制御メカニズムの解明2022
- Author(s)
  横山敦、野呂英理、松澤拓郎、吉川雄朗、島弘季、五十嵐和彦、菅原明
- Organizer
  第95会日本内分泌学会学術総会
- Data Source
  KAKENHI-PROJECT-21K11439
[Presentation] Functional regulation of the glucose-responsive transcription factor ChREBP by inflammatory signals.2022
- Author(s)
  Atsushi Yokoyama
- Organizer
  公益法人ときわ会先端医学研究センター 5周年記念国際シンポジウム
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21K11439
[Presentation] A Novel Hnf4α Receptor Corepressor, Irf2bp2: Its Role In The Gluconeogenic Gene Regulation Via Biochemically Labile Interaction2022
- Author(s)
  Kouketsu T, Yokoyama A, Monma R, Miyairi Y, Sawatsubashi S, Shima H, Igarashi K, Sugawara A.
- Organizer
  アメリカ内分泌学会
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21K19692
[Presentation] 核内受容体受容体新規転写共役因子の探索2022
- Author(s)
  横山敦、纐纈拓海、尾坪優李、沢津橋俊、島弘季、佐藤郁郎、川村貞文、鈴木貴、五十嵐和彦、菅原明
- Organizer
  日本アンドロロジー学会第41回学術大会　シンポジウム4　次世代研究者シンポジウム
- Invited
- Data Source
  KAKENHI-PROJECT-21K11439
[Presentation] 炎症シグナルによるグルコース応答性転写因子ChREBPの機能制御メカニズムの解明2022
- Author(s)
  横山敦、野呂英理、松澤拓郎、吉川雄朗、島弘季、五十嵐和彦、菅原明
- Organizer
  第42会日本内分泌学会東北地方会
- Data Source
  KAKENHI-PROJECT-21K11439
[Presentation] A Novel Hnf4α Receptor Corepressor, Irf2bp2: Its Role In The Gluconeogenic Gene Regulation Via Biochemically Labile Interaction2022
- Author(s)
  Kouketsu T, Yokoyama A, Monma R, Miyairi Y, Sawatsubashi S, Shima H, Igarashi K, Sugawara A.
- Organizer
  アメリカ内分泌学会
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20H04099
[Presentation] アンドロゲン受容体新規転写共役因子の探索2022
- Author(s)
  横山敦、纐纈拓海、尾坪優李、沢津橋俊、島弘季、佐藤郁郎、川村貞文、鈴木貴、五十嵐和彦、菅原明
- Organizer
  日本アンドロロジー学会第41回学術大会
- Data Source
  KAKENHI-PROJECT-21K11439
[Presentation] Examination of the effectiveness of diabetic nephropathy treatment targeting ChREBP activity2022
- Author(s)
  Suzuki S, Yokoyama A, Okamoto K, Iwabuchi Y, Sugawara A.
- Organizer
  アメリカ内分泌学会
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21K19692
[Presentation] 糖質応答性転写因子ChREBPを標的とした糖尿病性腎症に対する新規治療薬の開発2021
- Author(s)
  鈴木歩、横山敦、岩渕好治、菅原明
- Organizer
  第94回日本内分泌学会学術総会
- Data Source
  KAKENHI-PROJECT-21K19692
[Presentation] 糖尿病性腎症の発症・進展における腎近位尿細管ChREBPの機能解析2021
- Author(s)
  西澤翔輝、野呂英理香、鈴木歩、横山敦、岡本好司、菅原明
- Organizer
  第94回日本内分泌学会学術総会
- Data Source
  KAKENHI-PROJECT-21K19692
[Presentation] 未知の脂肪細胞由来因子による副腎CYP11B2発現誘導機序の解明2021
- Author(s)
  高橋馨、島田洋樹、佐藤郁子、横山敦、菅原明
- Organizer
  第94回日本内分泌学会学術総会
- Data Source
  KAKENHI-PROJECT-20H04099
[Presentation] 肝臓におけるHNF4αを介した糖新生遺伝子の転写制御メカニズムの解明2021
- Author(s)
  纐纈拓海、横山敦、菅原明
- Organizer
  第94回日本内分泌学会学術総会
- Data Source
  KAKENHI-PROJECT-20H04099
[Presentation] CYP11B2とKCNJ5変異体を標的とした原発性アルドステロン症の新規創薬2021
- Author(s)
  五十嵐萌、星啓太、横山敦、尾坪優李、島田洋樹、菅原明
- Organizer
  第94回日本内分泌学会学術総会
- Data Source
  KAKENHI-PROJECT-20H04099
[Presentation] 糖質応答性転写因子ChREBPを標的とした糖尿病性腎症に対する新規治療薬の開発2021
- Author(s)
  鈴木歩、横山敦、岩渕好治、菅原明
- Organizer
  第94回日本内分泌学会学術総会
- Data Source
  KAKENHI-PROJECT-20H04099
[Presentation] オーファン核内受容体HNF4αを標的とした抗グルカゴン作用薬の開発2021
- Author(s)
  末松渉、畠山慎治、横山敦、菅原明
- Organizer
  第94回日本内分泌学会学術総会
- Data Source
  KAKENHI-PROJECT-21K19692
[Presentation] 膵β細胞におけるグルコース応答性転写因子ChREBPの機能制御因子の探索2021
- Author(s)
  横山敦、野呂英理香、岡本好司、松澤拓郎、吉川雄朗、島弘季、五十嵐和彦、菅原明
- Organizer
  第94回日本内分泌学会学術総会
- Data Source
  KAKENHI-PROJECT-21K11439
[Presentation] 糖尿病性腎症の発症・進展における腎近位尿細管ChREBPの機能解析2021
- Author(s)
  西澤翔輝、野呂英理香、鈴木歩、横山敦、岡本好司、菅原明
- Organizer
  第94回日本内分泌学会学術総会
- Data Source
  KAKENHI-PROJECT-20H04099
[Presentation] 未知の脂肪細胞由来因子による副腎CYP11B2発現誘導機序の解明2021
- Author(s)
  高橋馨、島田洋樹、佐藤郁子、横山敦、菅原明
- Organizer
  第94回日本内分泌学会学術総会
- Data Source
  KAKENHI-PROJECT-21K19692
[Presentation] 肝臓におけるHNF4αを介した糖新生遺伝子の転写制御メカニズムの解明2021
- Author(s)
  纐纈拓海、横山敦、菅原明
- Organizer
  第94回日本内分泌学会学術総会
- Data Source
  KAKENHI-PROJECT-21K19692
[Presentation] CYP11B2とKCNJ5変異体を標的とした原発性アルドステロン症の新規創薬2021
- Author(s)
  五十嵐萌、星啓太、横山敦、尾坪優李、島田洋樹、菅原明
- Organizer
  第94回日本内分泌学会学術総会
- Data Source
  KAKENHI-PROJECT-21K19692
[Presentation] 炎症シグナルによるグルコース応答性転写因子ChREBPの機能制御メカニズムの解明2021
- Author(s)
  横山　敦、野呂　英理香、岡本好司、松澤拓郎、吉川雄朗、島弘季、五十嵐　和彦、菅原　明
- Organizer
  第94回日本生化学会大会
- Data Source
  KAKENHI-PROJECT-21K11439
[Presentation] タバコによるアンドロゲン受容体制御メカニズムの解析2021
- Author(s)
  小林　研太郎、横山　敦、清水　恭子、菅原　明
- Organizer
  第25回日本臨床内分泌病理学会
- Data Source
  KAKENHI-PROJECT-21K11439
[Presentation] オーファン核内受容体HNF4αを標的とした抗グルカゴン作用薬の開発2021
- Author(s)
  末松渉、畠山慎治、横山敦、菅原明
- Organizer
  第94回日本内分泌学会学術総会
- Data Source
  KAKENHI-PROJECT-20H04099
[Presentation] 糖尿病性腎症に対する糖質応答性転写因子ChREBPを標的とした新規治療薬開発の試み2020
- Author(s)
  鈴木歩、横山敦、岩渕好治、菅原明
- Organizer
  第63回日本糖尿病学会年次学術集会
- Data Source
  KAKENHI-PROJECT-20H04099
[Presentation] 糖尿病性腎症に対する糖質応答性転写因子ChREBPを標的とした新規治療薬開発の試み2020
- Author(s)
  鈴木歩、横山敦、岩渕好治、菅原明
- Organizer
  第63回日本糖尿病学会年次学術集会
- Data Source
  KAKENHI-PROJECT-19K22793
[Presentation] CYP11B2・変異KCNJ5を標的とした原発性アルドステロン症の新規創薬2020
- Author(s)
  星啓太、横山敦、五十嵐萌、島田洋樹、菅原明
- Organizer
  第93回日本内分泌学会学術総会
- Data Source
  KAKENHI-PROJECT-20H04099
[Presentation] 肝臓におけるHNF4αを介した糖新生遺伝子の転写機構の解明2020
- Author(s)
  門間里奈、宮入優里、横山　敦、菅原　明
- Organizer
  第93回日本内分泌学会学術総会
- Data Source
  KAKENHI-PROJECT-19K22793
[Presentation] 未知の脂肪細胞由来因子による副腎アルドステロン合成酵素（CYP11B2）発現亢進機序の解明2020
- Author(s)
  坂本　純、島田洋樹、高橋　馨、横山　敦、菅原　明
- Organizer
  第93回日本内分泌学会学術総会
- Data Source
  KAKENHI-PROJECT-20H04099
[Presentation] 肝臓におけるHNF4αを介した糖新生遺伝子の転写機構の解明2020
- Author(s)
  門間里奈、宮入優里、横山　敦、菅原　明
- Organizer
  第93回日本内分泌学会学術総会
- Data Source
  KAKENHI-PROJECT-20H04099
[Presentation] 未知の脂肪細胞由来因子による副腎アルドステロン合成酵素（CYP11B2）発現亢進機序の解明2020
- Author(s)
  坂本純、島田洋樹、高橋馨、横山敦、菅原明
- Organizer
  第93回日本内分泌学会学術総会
- Data Source
  KAKENHI-PROJECT-19K22793
[Presentation] CYP11B2・変異KCNJ5を標的とした原発性アルドステロン症の新規創薬2020
- Author(s)
  星啓太、横山敦、五十嵐萌、島田洋樹、菅原明
- Organizer
  第93回日本内分泌学会学術総会
- Data Source
  KAKENHI-PROJECT-19K22793
[Presentation] 脂肪細胞由来の未知のアルドステロン合成酵素（CYP11B2）発現誘導因子の探索2019
- Author(s)
  島田洋樹、佐藤郁子、坂本　純、横山　敦、菅原　明
- Organizer
  第42回日本高血圧学会総会
- Data Source
  KAKENHI-PROJECT-19K22793
[Presentation] An approach to identify the undetermined adipocyte-derived factor(s) that stimulate aldosterone synthase gene (CYP11B2) expression2019
- Author(s)
  Shimada H, Sato I, Sakamoto J, Yokoyama A, Sugawara A
- Organizer
  第92回日本内分泌学会学術総会日韓内分泌学会特別口演セッション
- Invited
- Data Source
  KAKENHI-PROJECT-19K22793
[Presentation] 未知の脂肪細胞由来因子による副腎CYP11B2発現誘導機序の解明2019
- Author(s)
  坂本　純、島田洋樹、横山　敦、菅原　明
- Organizer
  第42回日本高血圧学会総会
- Data Source
  KAKENHI-PROJECT-19K22793
[Presentation] An approach to identify the undetermined adipocyte-derived factor(s) that stimulate aldosterone synthase gene (CYP11B2) expression2019
- Author(s)
  Sakamoto J, Shimada H, Yokoyama A, Sugawara A
- Organizer
  ISARSH2019
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K22793
[Presentation] Possible Involvement of ChREBP in the Progression of Diabetic Kidney Disease in the Renal Tubules2018
- Author(s)
  Susumu Suzuki, Atsushi Yokoyama, Erika Noro, Satoshi Aoki, Rehana Parvin, Hiroki Shimada, Akira Sugawara
- Organizer
  ISN Frontiers Meeting 2018
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K15492
[Presentation] 前立腺癌細胞を用いたアンドロゲン受容体の新たな転写共役因子の探索2018
- Author(s)
  横山　敦，菅原　明
- Organizer
  第36回内分泌代謝学サマーセミナー
- Data Source
  KAKENHI-PROJECT-16K08606
[Presentation] Involvement of IKK complex in the regulation of a glucose-responsive transcriptional factor ChREBP in pancreatic β-cell2018
- Author(s)
  Erika Noro, Atsushi Yokoyama, Naotaka Kogure, Rina Momma, Kyoko Shimizu, Rehana Parvin, Susumu Suzuki, Hiroki Shimada, Hiroki Shima, Kazuhiko Igarashi, Akira Sugawara
- Organizer
  ENDO2018
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K15492
[Presentation] Identification of novel AR coregulators via endogenous purification2018
- Author(s)
  Atsushi Yokoyama, Erika Noro, Makoto Kobayashi, Kyoko Shimizu, Susumu Suzuki, Hiroki Shimada, Hiroki Shima, Kazuhiko Igarashi, Akira Sugawara
- Organizer
  ENDO 2018
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K08606
[Presentation] MEKT1, a novel PPAR-gamma agonist, significantly suppressed Pomc expression/ACTH secretion in AtT20 cells2018
- Author(s)
  Rehana Parvin, Akiko Saito-Hakoda, Hiroki Shimada, Erika Noro, Susumu Suzuki, Hiroyuki Miyachi Atsushi Yokoyama, Akira Sugawara
- Organizer
  ENDO2018
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K15492
[Presentation] 膵β細胞におけるグルコース応答性転写因子ChREBPの機能制御因子のRIME法を用いた探索2018
- Author(s)
  野呂英理香、横山敦、小暮直敬、鈴木歩、清水恭子、島弘季、五十嵐和彦、菅原明
- Organizer
  第92回日本内分泌学会学術総会
- Data Source
  KAKENHI-PROJECT-16K08606
[Presentation] Identification of novel AR coregulators via endogenous purification2018
- Author(s)
  Atsushi Yokoyama, Erika Noro, Makoto Kobayashi, Kyoko Shimizu, Susumu Suzuki, Hiroki Shimada, Hiroki Shima, Kazuhiko Igarashi, Akira Sugawara
- Organizer
  the 100th Annual Meeting of the Endocrine Society ENDO 2018
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K08606
[Presentation] Involvement of IKK Complex in the Regulation of a Glucose-Responsive Transcriptional Factor ChREBP in Pancreatic β-cell2018
- Author(s)
  Erika Noro, Atsushi Yokoyama, Naotaka Kogure, Rina Momma, Kyoko Shimizu, Rehana Parvin, Susumu Suzuki, Hiroki Shimada, Hiroki Shima, Kazuhiko Igarashi, Akira Sugawara
- Organizer
  ENDO 2018
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K08606
[Presentation] 新たな転写複合体同定の試み2016
- Author(s)
  横山敦
- Organizer
  第1回次世代生命科学の研究会
- Place of Presentation
  徳島大学（徳島県蔵本町）
- Year and Date
  2016-08-12
- Invited
- Data Source
  KAKENHI-PROJECT-16K08606
[Presentation] 新たな翻訳後修飾の探索2016
- Author(s)
  横山敦、菅原明
- Organizer
  第89会生化学会大会
- Place of Presentation
  仙台国際センター（宮城県仙台市）
- Year and Date
  2016-09-25
- Data Source
  KAKENHI-PROJECT-16K08606
[Presentation] Functional screening of transcriptional co-factors for a glucose-responsive transcriptional factor ChREBP.2016
- Author(s)
  Erika Noro, Atsushi Yokoyama, Naotaka Kogure, Kyoko Shimizu, Hiroki Shima, Kazuhiko Igarashi, Akira Sugawara
- Organizer
  ENDO2016
- Place of Presentation
  アメリカ合衆国ボストン市
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K15492
[Presentation] 遺伝子発現を制御する新たな翻訳後修飾の探索2013
- Author(s)
  横山敦
- Organizer
  第16回がん・エピゲノム研究会
- Place of Presentation
  宮城
- Year and Date
  2013-07-17
- Data Source
  KAKENHI-PROJECT-24658091
[Presentation] 組織特異的なヒストン修飾因子複合体の解析2013
- Author(s)
  横山敦
- Organizer
  第1回疾患エピゲノムコアセンターミニシンポジウム～未知の生命現象・疾患の解明を目指して～
- Place of Presentation
  宮城
- Year and Date
  2013-10-26
- Data Source
  KAKENHI-PROJECT-24658091
[Presentation] 核内受容体HNF4aの翻訳後修飾の網羅的同定2012
- Author(s)
  横山敦、桂彰吾、伊藤亮、橋場和華、関根弘樹、藤木亮次、加藤茂明
- Organizer
  日本農芸化学会2012年度大会
- Place of Presentation
  京都女子大学
- Year and Date
  2012-03-24
- Data Source
  KAKENHI-PROJECT-22780086
[Presentation] 遺伝子発現を制御する新たな翻訳後修飾の探索2012
- Author(s)
  横山敦
- Organizer
  新学術領域研究「性差構築の分子基盤」領域会議
- Place of Presentation
  和歌山ﾏﾘｰﾅｼﾃｨﾛｲﾔﾙﾊﾟｲﾝｽﾞﾎﾃﾙ
- Data Source
  KAKENHI-PROJECT-24658091
[Presentation] 遺伝子発現を制御する新たな翻訳後修飾の探索2012
- Author(s)
  横山敦
- Organizer
  新学術領域研究「性差構築の分子基盤」領域会議
- Place of Presentation
  和歌山
- Year and Date
  2012-10-15
- Data Source
  KAKENHI-PROJECT-24658091
[Presentation] オーファン核内受容体HNF4の翻訳後修飾の網羅的解析2011
- Author(s)
  横山敦、橋場和華、関根弘樹、藤木亮次、加藤茂明
- Organizer
  加藤茂明オーファン核内受容体HNF4の翻訳後修飾の網羅的解析第5回日本エピジェネティクス研究会年会
- Place of Presentation
  KKRホテル熊本
- Year and Date
  2011-05-20
- Data Source
  KAKENHI-PROJECT-22780086
[Presentation] Multiple post-translational modifications in Hepatocyte nuclear factor 4 alpha2011
- Author(s)
  Yokoyama A, Katsura S, Ito R, Hashiba W, Sekine H, Fujiki R and Kato S
- Organizer
  EMBO conference nuclear receptors From molecular mechanism to health & disease
- Place of Presentation
  シッチェス、バルセロナ,スペイン
- Year and Date
  2011-09-19
- Data Source
  KAKENHI-PROJECT-22780086
[Presentation] Multiple post-translational modifications in Hepatocyte nuclear factor 4 alpha2011
- Author(s)
  Yokoyama A, Katsura S, Ito R, Hashiba W, Sekine H, Fujiki R and Kato S
- Organizer
  第34回日本分子生物学会年会
- Place of Presentation
  パシフィコ横浜
- Year and Date
  2011-12-15
- Data Source
  KAKENHI-PROJECT-22780086
[Presentation] Comprehensive analysis of post-translational modifications in hepatocyte nuclear factor 4 alpha2011
- Author(s)
  Yokoyama A, Katsura S, Ito R, Hashiba W, Sekine H, Fujiki R and Kato S
- Organizer
  Cold Spring Harbor Symposium on Quantitative Biology
- Place of Presentation
  コールドスプリングハーバー研究所、米国
- Year and Date
  2011-06-05
- Data Source
  KAKENHI-PROJECT-22780086
[Presentation] オーファン核内受容体HNF4の翻訳後修飾の網羅的解析2011
- Author(s)
  横山敦、橋場和華、関根弘樹、藤木亮次、加藤茂明
- Organizer
  第5回日本エピジェネティクス研究会年会
- Place of Presentation
  KKRホテル熊本
- Year and Date
  2011-05-20
- Data Source
  KAKENHI-PROJECT-22780086
[Presentation] ピストン脱メチル化酵素による神経分化制御メカニズムの解析2010
- Author(s)
  横山敦、奥野陽亮、橋場和華、関根弘樹、藤山沙理、北川浩史、藤木亮次、加藤茂明
- Organizer
  日本生化学会・分子生物学会合同大会
- Place of Presentation
  神戸
- Year and Date
  2010-12-08
- Data Source
  KAKENHI-PROJECT-22780086
[Presentation] 遺伝子発現を制御する新たな翻訳後修飾の探索
- Author(s)
  横山敦
- Organizer
  第１６回がん・エピゲノム研究会
- Place of Presentation
  艮陵会館　記念ホール（宮城県仙台市）
- Invited
- Data Source
  KAKENHI-PROJECT-24658091
[Presentation] 組織特異的なヒストン修飾因子複合体の解析
- Author(s)
  横山敦
- Organizer
  第１回　疾患エピゲノムコアセンター　ミニシンポジウム～未知の生命現象・疾患の解明を目指して～
- Place of Presentation
  東北大学医学部（宮城県仙台市）
- Invited
- Data Source
  KAKENHI-PROJECT-24658091

1. Sugawara Akira (90270834)

# of Collaborated Projects: 7 results

# of Collaborated Products: 48 results
2. 岩渕好治 (20211766)

# of Collaborated Projects: 4 results

# of Collaborated Products: 5 results
3. 岡本好司 (80572247)

# of Collaborated Projects: 3 results

# of Collaborated Products: 2 results
4. SAWATUBASHI Shun (70535103)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
5. MOROHASHI Ken-ichirou (30183114)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
6. SHIMA Yuichi (80425420)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
7. BABA Takashi (40435524)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
8. MATSUMOTO Takahiro (70447374)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
9. TAKEMOTO Tatsuya (30443899)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
10. YAMAMOTO Yasuhiko (20313637)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
11. TAKAGI Kiyoshi (80595562)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
12. Sato Horoshi (60215829)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
13. ITO Ryo (80733815)

# of Collaborated Projects: 1 results

# of Collaborated Products: 4 results
14. DOI Takayuki (90212076)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
15. 広川貴次 (20357867)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
16. 井上淳 (60455821)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
17. SHIMA hiroki

# of Collaborated Projects: 1 results

# of Collaborated Products: 8 results
18. NORO erika

# of Collaborated Projects: 1 results

# of Collaborated Products: 8 results
19. SATO Kosei

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
20. SHIMADA hiroki

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results
21. MORITA Masanobu

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
22. MIZUMOTO Shuji

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
23. TAKADA Ichiro

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
24. 小林隆志

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
25. 五十嵐勝秀

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
26. 菅原一幸

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
27. 山田修平

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
28. 小西博昭

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
29. 高橋さゆり

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
30. YOUN M.-Y.

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results
31. 鈴木貴

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
32. 五十嵐和彦

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Yokoyama Atsushi 横山 敦

YOKOYAMA Atsushi 横山 敦

Research Projects

Research Products

Co-Researchers

糖質応答転写因子ChREBPの新規阻害薬を用いた糖尿病性腎臓病の病態解明・制御

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新規ChREBP阻害薬の標的遺伝子に対するPerturbシークエンスを用いたNAFLDの病態制御

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Identification and analysis of a pioneer factor for androgen receptor in skeletal musclePrincipal Investigator

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Innovation of novel therapeutics against diabetic nephropathy

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Innovation of a novel DN medication by targeting ChREBP

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Identification of a novel adipocyte-derived factor that elevates blood pressure using VIKING method

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Screening of drug target proteins for diabetic nephropathy by identification of ChREBP complex from renal mesangial cellsPrincipal Investigator

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Innovation of novel therapeutics against diabetic nephropathy targeting ChREBP

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Identification of novel PTMsPrincipal Investigator

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Analysis of nuclear lipidation in gene regulationPrincipal Investigator

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Establishment of sex differences through sex-specific enhancer

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[Book] 細胞内発現タンパク質の精製と解析2010

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[Journal Article] ESS2 controls prostate cancer progression through recruitment of chromodomain helicase DNA binding protein 1.2023

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DOI

Yokoyama Atsushi 横山敦

YOKOYAMA Atsushi 横山敦