Kubota Tomoya 久保田智哉

… Alternative Names

久保田智哉クボタトモヤ

KUBOTA TOMOYA 久保田智哉

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Researcher Number	20573231
Other IDs
Affiliation (Current)	2025: 大阪大学, 大学院医学系研究科, 准教授
Affiliation (based on the past Project Information) *help	2025: 大阪大学, 大学院医学系研究科, 准教授 2022 – 2023: 大阪大学, 大学院医学系研究科, 准教授 2019 – 2020: 大阪大学, 医学系研究科, 准教授 2018: 大阪大学, 医学系研究科, 助教
Review Section/Research Field	Principal Investigator Basic Section 52020:Neurology-related
Keywords	Principal Investigator Cav2.1 / EA1 / EA2 / 反復発作性運動失調症 / チャネル病 / 遺伝子解析 / ナトリウムチャネル / カリウムチャネル / カルシウムチャネル / 神経筋チャネル病 … More / EA9 / 電位依存性カリウムチャネル / 電位依存性カルシウムチャネル / 電位感受性機構 / 電位依存性イオンチャネル / 運動失調 Less

神経チャネル病の新規治療薬開発の基盤となるモデル細胞及びスクリーニング系の確立Principal Investigator
- Principal Investigator
  
  久保田智哉
- Project Period (FY)
  2025 – 2027
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 52020:Neurology-related
- Research Institution
  The University of Osaka
神経筋チャネル病の遺伝子型・表現型相関解明を目指した診断パイプラインの構築Principal Investigator
- Principal Investigator
  
  久保田智哉
- Project Period (FY)
  2022 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 52020:Neurology-related
- Research Institution
  Osaka University
Exploring novel causative gennetic variants and the pathomechanism of Episodic ataxiaPrincipal Investigator
- Principal Investigator
  
  KUBOTA TOMOYA
- Project Period (FY)
  2018 – 2020
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 52020:Neurology-related
- Research Institution
  Osaka University

All 2023 2022 2020 2019

All Journal Article Presentation

[Journal Article] Optical measurement of gating pore currents in hypokalemic periodic paralysis model cells2023
- Author(s)
  Kubota Tomoya、Takahashi Satoe、Yamamoto Risa、Sato Ruka、Miyanooto Aya、Yamamoto Reina、Yamauchi Kosuke、Homma Kazuaki、Takahashi Masanori P.
- Journal Title
  
  Disease Models & Mechanisms
  
  Volume: 16 Issue: 6
- DOI
  10.1242/dmm.049704
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-22K07493
[Journal Article] Hyperkalemic periodic paralysis associated with a novel missense variant located in the inner pore of Nav1.4.2023
- Author(s)
  Segawa K, Nishiyama M, Mori I, Kubota T, Takahashi MP.
- Journal Title
  
  Brain Dev.
  
  Volume: 45(4) Issue: 4 Pages: 205-211
- DOI
  10.1016/j.braindev.2022.12.003
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22K07493, KAKENHI-PROJECT-22K09119
[Journal Article] Periodic paralysis due to cumulative effects of rare variants in SCN4A with small functional alterations.2022
- Author(s)
  Shibano M, Kubota T, Kokubun N, Miyaji Y, Kuriki H, Ito Y, Hamanoue H, Takahashi MP.
- Journal Title
  
  Muscle Nerve.
  
  Volume: 66(6) Issue: 6 Pages: 757-761
- DOI
  10.1002/mus.27725
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22K07493
[Journal Article] EF hand‐like motif mutations of Nav1.4 C‐terminus cause myotonic syndrome by impairing fast inactivation2020
- Author(s)
  Horie Riho、Kubota Tomoya、Koh Jinsoo、Tanaka Rieko、Nakamura Yuichiro、Sasaki Ryogen、Ito Hidefumi、Takahashi Masanori P.
- Journal Title
  
  Muscle & Nerve
  
  Volume: 61 Issue: 6 Pages: 808-814
- DOI
  10.1002/mus.26849
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18K07524
[Journal Article] Analysis of the genetic background associated with sporadic periodic paralysis in Japanese patients2020
- Author(s)
  Nakaza Maki、Kitamura Yuri、Furuta Mitsuru、Kubota Tomoya、Sasaki Ryogen、Takahashi Masanori P.
- Journal Title
  
  Journal of the Neurological Sciences
  
  Volume: 412 Pages: 116795-116795
- DOI
  10.1016/j.jns.2020.116795
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18K07524
[Journal Article] Mutation spectrum and health status in skeletal muscle channelopathies in Japan2020
- Author(s)
  Sasaki Ryogen、Nakaza Maki、Furuta Mitsuru、Fujino Haruo、Kubota Tomoya、Takahashi Masanori P.
- Journal Title
  
  Neuromuscular Disorders
  
  Volume: 30 Issue: 7 Pages: 546-553
- DOI
  10.1016/j.nmd.2020.06.001
- NAID
  120007181345
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18K07524
[Journal Article] Hypokalaemic periodic paralysis with a charge-retaining substitution in the voltage sensor2020
- Author(s)
  Kubota Tomoya、Wu Fenfen、Vicart Savine、Nakaza Maki、Sternberg Damien、Watanabe Daisuke、Furuta Mitsuru、Kokunai Yosuke、Abe Tatsuya、Kokubun Norito、Fontaine Bertrand、Cannon Stephen C、Takahashi Masanori P
- Journal Title
  
  Brain Communications
  
  Volume: 2 Issue: 2
- DOI
  10.1093/braincomms/fcaa103
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K07524
[Presentation] Andersen-Tawil症候群における疾患変異チャネルの膜発現効率の定量化2023
- Author(s)
  山中彩郁、福本蒼乃、山本瑞希、山本玲奈、山内亨祐、髙橋里枝、本間和明、久保田智哉、髙橋正紀
- Organizer
  第9回日本筋学会学術集会
- Data Source
  KAKENHI-PROJECT-22K07493
[Presentation] 反復発作性運動失調症の変異チャネル機能解析に基づく診断パイプラインの構築2023
- Author(s)
  山本瑞希、田口晴菜、榊原由奈、山本玲奈、山内亨祐、髙橋里枝、本間和明、久保田智哉、髙橋正紀
- Organizer
  第53回日本臨床神経生理学会学術大会
- Data Source
  KAKENHI-PROJECT-22K07493
[Presentation] OPTICAL MEASUREMENT OF GATING PORE CURRENTS IN HYPOKALEMIC PERIODIC PARALYSIS MODEL CELLS.2023
- Author(s)
  Tomoya Kubota, Satoe Takahashi, Risa Yamamoto, Ruka Sato, Aya Miyanooto, Reina Yamamoto, Kosuke Yamauchi, Kazuaki Homma, Masanori P. Takahashi
- Organizer
  67th Annual Meeting of the Biophysical Society
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-22K07493
[Presentation] イオンチャネル異常症の膜発現効率の定量的評価法の開発とNav1.4変異チャネルによる評価2023
- Author(s)
  山本玲奈, 山内亨祐, 髙橋里枝, 本間和明, 久保田智哉, 髙橋正紀
- Organizer
  第53回日本臨床神経生理学会学術大会
- Data Source
  KAKENHI-PROJECT-22K07493
[Presentation] チャネル機能に基づくチャネル病診断パイプラインの構築2023
- Author(s)
  久保田智哉、高橋正紀
- Organizer
  生理研究会2023
- Data Source
  KAKENHI-PROJECT-22K07493
[Presentation] Cy3-based membrane protein targeting assay for quantitative evaluation of membrane expression efficacy of ion channels2023
- Author(s)
  Reina Yamamoto, Kosuke Yamauchi, Satoe Takahashi, Aono Fukumoto, Mizuki Yamamoto, Masanori P. Takahashi, Kazuaki Homma, Tomoya Kubota
- Organizer
  日本生理学会第100回大会
- Data Source
  KAKENHI-PROJECT-22K07493
[Presentation] Functional analysis of voltage-gated ion channels with voltage sensor mutations in channelopathies.2023
- Author(s)
  Tomoya Kubota
- Organizer
  日本生理学会第100回大会　シンポジウム2S06e
- Data Source
  KAKENHI-PROJECT-22K07493
[Presentation] 低カリウム性周期性四肢麻痺の疾患モデル細胞作製にむけた電気生理学的検証2023
- Author(s)
  宮野音亜也、山本理沙、久保田智哉、髙橋正紀
- Organizer
  第53回日本臨床神経生理学会学術大会
- Data Source
  KAKENHI-PROJECT-22K07493
[Presentation] 筋チャネル病の病態解析2023
- Author(s)
  久保田智哉
- Organizer
  第97回日本薬理学会年会　公募シンポジウム2-B-S40：骨格筋恒常性維持における受容体・チャネル研究の最前線
- Data Source
  KAKENHI-PROJECT-22K07493
[Presentation] 骨格筋型電位依存性ナトリウムチャネル遺伝子(SCN4A)のエクソン境界の変異による筋疾患の病態解析2023
- Author(s)
  吉良夏希、久保田智哉、吉田亘佑、木村隆、髙橋正紀
- Organizer
  第9回日本筋学会学術集会
- Data Source
  KAKENHI-PROJECT-22K07493
[Presentation] Generation of in vitro model cells for skeletal muscle channelopathies.2023
- Author(s)
  Kubota T, Takahashi S, Yamamoto R, Sato R, Miyanooto A, Yamamoto R, Yamauchi K, Homma K, Takahashi MP.
- Organizer
  第64回日本神経学会学術大会
- Data Source
  KAKENHI-PROJECT-22K07493
[Presentation] Optical measurement of gating pore currents in hypokalemic periodic paralysis model cells.2023
- Author(s)
  Kubota T, Takahashi S, Yamamoto R, Sato R, Miyanooto A, Yamamoto R, Yamauchi K, Homma K, Takahashi MP.
- Organizer
  Ion channel modulation symposium 2023.
- Data Source
  KAKENHI-PROJECT-22K07493
[Presentation] Functional characterization of mutations identified in skeletal muscle channelopathy in Japan2020
- Author(s)
  Tomoya Kubota
- Organizer
  第97回日本生理学会大会（誌上開催）
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K07524
[Presentation] EF hand-like motif mutations of Nav1.4 C-terminus impair fast inactivation associated with myotonic syndrome2020
- Author(s)
  Riho Horie, Tomoya Kubota, Jinsoo Koh, Rieko Tanaka, Yuichiro Nakamura, Ryogen Sasaki, Hidefumi Ito, Masanori P. Takahashi,
- Organizer
  64th Annual Meeting of the Biophysical Society
- Data Source
  KAKENHI-PROJECT-18K07524
[Presentation] SCN4A遺伝子の追加変異による周期性四肢麻痺の高K性から低K性へのスイッチ2020
- Author(s)
  芝野　真紀、久保田　智哉、國分　則人、栗城　紘子、伊藤　譲、浜之上　はるか、高橋　正紀
- Organizer
  第6回日本筋学会（Web開催）
- Data Source
  KAKENHI-PROJECT-18K07524
[Presentation] Hypokalemic periodic paralysis with a charge-retaining substitution in the voltage sensor2020
- Author(s)
  久保田智哉, Fenfen Wu, Savine Vicart, 仲座真希, Damien Sternberg, 渡邉大祐,阿部達哉, 國分則人, Bertrand Fontaine, Stephen C. Cannon, 髙橋正紀
- Organizer
  2020年生理学研究所研究会（on Zoom)
- Data Source
  KAKENHI-PROJECT-18K07524
[Presentation] 神経チャネル病の患者遺伝子解析の現状と問題点2020
- Author(s)
  佐藤瑠香、久保田智哉、髙橋正紀
- Organizer
  2020年生理学研究所研究会（on Zoom)
- Data Source
  KAKENHI-PROJECT-18K07524
[Presentation] 本邦における反復発作性運動失調症の実態把握調査研究2019
- Author(s)
  久保田智哉、高橋正紀、石川欽也、杉浦嘉泰，高橋祐二、水澤英洋
- Organizer
  第60回日本神経学会学術大会
- Data Source
  KAKENHI-PROJECT-18K07524
[Presentation] 日本における反復発作性運動失調症の臨床像について2019
- Author(s)
  久保田智哉，高橋正紀，石川欽也，杉浦嘉泰，髙橋祐二、水澤英洋
- Organizer
  日本人類遺伝学会第64回大会
- Data Source
  KAKENHI-PROJECT-18K07524
[Presentation] 先天性パラミオトニーにともなう3種のC端に位置する変異ナトリウムチャネルの機能解析2019
- Author(s)
  堀江里歩、久保田智哉、高真守、田中里江子、中村優一郎、佐々木良元、伊東秀文、髙橋正紀
- Organizer
  第5回日本筋学会
- Data Source
  KAKENHI-PROJECT-18K07524

1. 高橋正紀 (20359847)

# of Collaborated Projects: 1 results

# of Collaborated Products: 8 results

Kubota Tomoya 久保田 智哉

久保田 智哉 クボタ トモヤ

KUBOTA TOMOYA 久保田 智哉

Research Projects

Research Products

Co-Researchers

神経チャネル病の新規治療薬開発の基盤となるモデル細胞及びスクリーニング系の確立Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

神経筋チャネル病の遺伝子型・表現型相関解明を目指した診断パイプラインの構築Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Exploring novel causative gennetic variants and the pathomechanism of Episodic ataxiaPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

[Journal Article] Optical measurement of gating pore currents in hypokalemic periodic paralysis model cells2023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Hyperkalemic periodic paralysis associated with a novel missense variant located in the inner pore of Nav1.4.2023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Periodic paralysis due to cumulative effects of rare variants in SCN4A with small functional alterations.2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] EF hand‐like motif mutations of Nav1.4 C‐terminus cause myotonic syndrome by impairing fast inactivation2020

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Analysis of the genetic background associated with sporadic periodic paralysis in Japanese patients2020

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Mutation spectrum and health status in skeletal muscle channelopathies in Japan2020

Author(s)

Journal Title

DOI

NAID

Data Source

[Journal Article] Hypokalaemic periodic paralysis with a charge-retaining substitution in the voltage sensor2020

Author(s)

Journal Title

DOI

Data Source

[Presentation] Andersen-Tawil症候群における疾患変異チャネルの膜発現効率の定量化2023

Author(s)

Organizer

Data Source

[Presentation] 反復発作性運動失調症の変異チャネル機能解析に基づく診断パイプラインの構築2023

Author(s)

Organizer

Data Source

[Presentation] OPTICAL MEASUREMENT OF GATING PORE CURRENTS IN HYPOKALEMIC PERIODIC PARALYSIS MODEL CELLS.2023

Author(s)

Organizer

Data Source

[Presentation] イオンチャネル異常症の膜発現効率の定量的評価法の開発とNav1.4変異チャネルによる評価2023

Author(s)

Organizer

Data Source

[Presentation] チャネル機能に基づくチャネル病診断パイプラインの構築2023

Author(s)

Organizer

Data Source

Kubota Tomoya 久保田智哉

久保田智哉クボタトモヤ

KUBOTA TOMOYA 久保田智哉