Ogura Jiro 小倉次郎

… Alternative Names

OGURA Jiro 小倉次郎

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Researcher Number	20580640
Other IDs
External Links
Affiliation (Current)	2025: 山形大学, 医学部, 准教授
Affiliation (based on the past Project Information) *help	2024: 山形大学, 医学部, 准教授 2020 – 2022: 山形大学, 医学部, 准教授 2018 – 2019: 東北大学, 大学病院, 助教 2012 – 2014: 北海道大学, 薬学研究科(研究院), 助教 2010 – 2011: 北海道大学, 大学院・薬学研究院, 助教
Review Section/Research Field	Principal Investigator Basic Section 38050:Food sciences-related / Applied pharmacology / 0801:Pharmaceutical sciences and related fields / Eating habits, studies on eating habits
Keywords	Principal Investigator PDI / 酸化ストレス / 痛風 / タンパク質修飾 / フラボノイド / 認知症 / 小胞体ストレス / S-ニトロソ化 / 基質結合ドメイン / S-ニトロシル化 … More / 神経変性疾患 / 加齢 / 薬物動態学的特性 / 薬力学的特性 / 抗酸化物質 / BCRP / ジスルフィド結合 / トランスポータ / 活性酸素 / キサンチンオキシダーゼ Less

Research Projects
(6 results)
Research Products
(22 results)

認知症予防のための栄養強化・補助食品の開発に向けたリード化合物の探索Principal Investigator
- Principal Investigator
  
  小倉次郎
- Project Period (FY)
  2024 – 2026
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 38050:Food sciences-related
- Research Institution
  Yamagata University
The development of dementia prevention by the S-nitrosylated PDI de-modification effecct using food componets.Principal Investigator
- Principal Investigator
  
  Ogura Jiro
- Project Period (FY)
  2020 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 38050:Food sciences-related
- Research Institution
  Yamagata University
Identification of PDI S-nitrosylated site and the relation S-nitrosylated PDI with neurodegenerationPrincipal Investigator
- Principal Investigator
  
  Ogura Jiro
- Project Period (FY)
  2018 – 2019
- Research Category
  
  Grant-in-Aid for Research Activity Start-up
- Review Section
  
  0801:Pharmaceutical sciences and related fields
- Research Institution
  Tohoku University
加齢性酸化ストレスによる尿酸輸送担体BCRPのS-S bond形成抑制機構の解明Principal Investigator
- Principal Investigator
  
  小倉次郎
- Project Period (FY)
  2014
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Applied pharmacology
- Research Institution
  Hokkaido University
Strategy for gout prevention based on pharmacodynamics and pharmacokinetics of antioxidantsPrincipal Investigator
- Principal Investigator
  
  OGURA Jiro
- Project Period (FY)
  2012 – 2013
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Eating habits, studies on eating habits
- Research Institution
  Hokkaido University
Effect of oxidative stress on disulfide bond formation of uric acid efflux transporter BCRPPrincipal Investigator
- Principal Investigator
  
  OGURA Jiro
- Project Period (FY)
  2010 – 2011
- Research Category
  
  Grant-in-Aid for Research Activity Start-up
- Research Field
  
  Applied pharmacology
- Research Institution
  Hokkaido University

All 2023 2022 2021 2020 2019 2014 2013 2012

All Journal Article Presentation

[Journal Article] Glutathione depletion results in S-nitrosylation of protein disulfide isomerase in neuroblastoma cells2023
- Author(s)
  Shinji Ono, Jiro Ogura, Hiroki Sugiura, Minami Yamauchi, Atsushi Tanaka, Toshihiro Sato, Masamitsu Maekawa, Hiroaki Yamaguchi, Nariyasu Mano
- Journal Title
  
  Life Sciences
  
  Volume: 316 Pages: 121442-121442
- DOI
  10.1016/j.lfs.2023.121442
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20K05873, KAKENHI-PROJECT-23K06231
[Journal Article] Association of Abnormal Disulfide Bond Formation with Disease Development and Progression2022
- Author(s)
  小倉次郎
- Journal Title
  
  YAKUGAKU ZASSHI
  
  Volume: 142 Issue: 10 Pages: 1055-1060
- DOI
  10.1248/yakushi.22-00119
- ISSN
  0031-6903, 1347-5231
- Year and Date
  2022-10-01
- Language
  Japanese
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20K05873
[Journal Article] Glucose-induced oxidative stress leads to in S-nitrosylation of protein disulfide isomerase in neuroblastoma cells2021
- Author(s)
  Ogura Jiro、Sugiura Hiroki、Tanaka Atsushi、Ono Shinji、Sato Toshiyuki、Sato Toshihiro、Maekawa Masamitsu、Yamaguchi Hiroaki、Mano Nariyasu
- Journal Title
  
  Biochimica et Biophysica Acta (BBA) - General Subjects
  
  Volume: 1865 Issue: 11 Pages: 129998-129998
- DOI
  10.1016/j.bbagen.2021.129998
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20K05873
[Journal Article] Stimulatory effect on the transport mediated by organic anion transporting polypeptide 2B12020
- Author(s)
  Ogura Jiro、Yamaguchi Hiroaki、Mano Nariyasu
- Journal Title
  
  Asian Journal of Pharmaceutical Sciences
  
  Volume: 15 Issue: 2 Pages: 181-191
- DOI
  10.1016/j.ajps.2019.10.004
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K21219
[Journal Article] Cysteine 343 in the substrate binding domain is the primary S-Nitrosylated site in protein disulfide isomerase2020
- Author(s)
  Ogura Jiro、Ruddock Lloyd W.、Mano Nariyasu
- Journal Title
  
  Free Radical Biology and Medicine
  
  Volume: 160 Pages: 103-110
- DOI
  10.1016/j.freeradbiomed.2020.07.029
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K05873
[Journal Article] Quercetin-3-rhamnoglucoside (rutin) stimulates transport of organic anion compounds mediated by organic anion transporting polypeptide 2B1.2014
- Author(s)
  Ogura J, Koizumi T, Segawa M, Yabe K, Kuwayama K, Sasaki S, Kaneko C, Tsujimoto T, Kobayashi M, Yamaguchi H, Iseki K.
- Journal Title
  
  Biopharm Drug Dispos.
  
  Volume: 35 Issue: 3 Pages: 173-182
- DOI
  10.1002/bdd.1882
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24700819
[Journal Article] (1st/14) Intestinal ischemia-reperfusion increases efflux for uric acid via paracellular route in the intestine, but decreases that via transcellular route mediated by Bcrp2012
- Author(s)
  Ogura J
- Journal Title
  
  J. Pharm. Pharm. Sci
  
  Volume: 15 Pages: 295-304
- URL
  http://ejournals.library.ualberta.ca/index.php/JPPS/article/view/12242
- Data Source
  KAKENHI-PROJECT-22890003
[Presentation] 神経変性疾患におけるPDIのSNO化に対する抗酸化物質の脱修飾効果2023
- Author(s)
  小倉次郎，山口浩明
- Organizer
  日本薬学会第143年会
- Data Source
  KAKENHI-PROJECT-20K05873
[Presentation] タンパク質ジスルフィド形成酵素protein disulfide isomeraseのS-ニトロシル化位置の同定2022
- Author(s)
  小倉次郎，Lloyd Ruddock，杉浦弘樹，小野慎司，眞野成康，山口浩明．
- Organizer
  日本薬学会第142年会
- Invited
- Data Source
  KAKENHI-PROJECT-20K05873
[Presentation] タンパク質ジスルフィド結合形成酵素PDIのS-ニトロシル化による神経変性の発生・進展メカニズムの検証2022
- Author(s)
  小倉次郎，山口浩明
- Organizer
  第54回日本臨床検査医学会東北支部総会・第33回日本臨床化学会東北支部総会
- Invited
- Data Source
  KAKENHI-PROJECT-20K05873
[Presentation] タンパク質ジスルフィド結合形成異常と疾患発症・進展との関連2021
- Author(s)
  小倉次郎.
- Organizer
  第43回東北薬学セミナー
- Invited
- Data Source
  KAKENHI-PROJECT-20K05873
[Presentation] 神経細胞外のグルタミン酸によるグルタチオン枯渇はProtein disulfide isomeraseのニトロシル化を誘導する2021
- Author(s)
  小倉次郎，小野慎司，杉浦弘樹，山内碧，佐藤紀宏，前川正充，山口浩明，眞野成康．
- Organizer
  第31回日本医療薬学会年会
- Data Source
  KAKENHI-PROJECT-20K05873
[Presentation] グルタチオン合成阻害によるグルタチオン枯渇はProtein disulfide isomeraseのS-ニトロシル化を誘導する2021
- Author(s)
  小倉次郎，小野慎司，杉浦弘樹，山内碧，佐藤紀宏，前川正充，眞野成康，山口浩明．
- Organizer
  第42回日本臨床薬理学会学術総会
- Data Source
  KAKENHI-PROJECT-20K05873
[Presentation] Protein disulfide isomeraseのニトロシル化位置の同定2021
- Author(s)
  小倉次郎，Lloyd Ruddock，山口浩明，眞野成康．
- Organizer
  第74回日本酸化ストレス学会学術集会
- Data Source
  KAKENHI-PROJECT-20K05873
[Presentation] 糖質負荷による神経変性とUnfolded Protein Response遺伝子の経時変化の関連2020
- Author(s)
  佐藤稔之、小倉次郎、杉浦弘樹、小野慎司、眞野成康
- Organizer
  日本薬学会第140年会
- Data Source
  KAKENHI-PROJECT-19K21219
[Presentation] 神経細胞におけるProtein disulfide isomerase基質結合ドメインのニトロシル化の影響2020
- Author(s)
  小倉次郎, Lloyd Ruddock, 眞野成康
- Organizer
  第30回日本医療薬学会年会
- Data Source
  KAKENHI-PROJECT-20K05873
[Presentation] 糖質負荷によるUnfolded Protein Responseマーカーの経時変化の検証2019
- Author(s)
  杉浦弘樹、小倉次郎、佐藤稔之、小野慎司、眞野成康
- Organizer
  第59回日本臨床化学会年次学術集会
- Data Source
  KAKENHI-PROJECT-19K21219
[Presentation] PDI基質結合部位のニトロソ化が誘導する小胞体ストレスマーカーの探索2019
- Author(s)
  小野慎司、小倉次郎、杉浦弘樹、眞野成康
- Organizer
  第59回日本臨床化学会年次学術集会
- Data Source
  KAKENHI-PROJECT-19K21219
[Presentation] Activation of xanthine oxidase suppresses excretion of uric acid to the intestinal lumen.2014
- Author(s)
  Ogura J, Kuwayama K, Sasaki S, Kaneko C, Koizumi T, Yabe K, Iseki K.
- Organizer
  17th Biennial Meeting of Society for Free Radical Research International
- Place of Presentation
  京都 (国立京都国際会館）
- Data Source
  KAKENHI-PROJECT-24700819
[Presentation] (1st/7) Activation of xanthine oxidase suppresses excretion of uric acid to the intestinal lumen2014
- Author(s)
  Ogura J, et al
- Organizer
  17th Biennial Meeting of Society for Free Radical Research International
- Place of Presentation
  京都(国立京都国際会館)
- Data Source
  KAKENHI-PROJECT-24700819
[Presentation] Activation of xanthine oxidase suppresses disulfide bond formation of breast cancer resistance protein in Caco-2 cells.2013
- Author(s)
  Ogura J, Sasaki S, Kuwayama K, Kaneko C, Koizumi T, Yabe K, Yamaguchi H, Iseki K.
- Organizer
  10th International ISSX Meeting
- Place of Presentation
  Toronto (Westin Harbour Castle Hotel)
- Data Source
  KAKENHI-PROJECT-24700819
[Presentation] (1st/8) Activation of xanthine oxidase suppresses disulfide bond formation of breast cancer resistance protein in Caco-2 cells2013
- Author(s)
  Ogura J, et al
- Organizer
  10th International ISSX Meeting
- Place of Presentation
  Toronto (Westin Harbour Castle Hotel)
- Data Source
  KAKENHI-PROJECT-24700819

Ogura Jiro 小倉 次郎

OGURA Jiro 小倉 次郎

Research Projects

Research Products

認知症予防のための栄養強化・補助食品の開発に向けたリード化合物の探索Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

The development of dementia prevention by the S-nitrosylated PDI de-modification effecct using food componets.Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Identification of PDI S-nitrosylated site and the relation S-nitrosylated PDI with neurodegenerationPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

加齢性酸化ストレスによる尿酸輸送担体BCRPのS-S bond形成抑制機構の解明Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Strategy for gout prevention based on pharmacodynamics and pharmacokinetics of antioxidantsPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Effect of oxidative stress on disulfide bond formation of uric acid efflux transporter BCRPPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] Glutathione depletion results in S-nitrosylation of protein disulfide isomerase in neuroblastoma cells2023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Association of Abnormal Disulfide Bond Formation with Disease Development and Progression2022

Author(s)

Journal Title

DOI

ISSN

Year and Date

Language

Data Source

[Journal Article] Glucose-induced oxidative stress leads to in S-nitrosylation of protein disulfide isomerase in neuroblastoma cells2021

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Stimulatory effect on the transport mediated by organic anion transporting polypeptide 2B12020

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Cysteine 343 in the substrate binding domain is the primary S-Nitrosylated site in protein disulfide isomerase2020

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Quercetin-3-rhamnoglucoside (rutin) stimulates transport of organic anion compounds mediated by organic anion transporting polypeptide 2B1.2014

Author(s)

Journal Title

DOI

Data Source

[Journal Article] (1st/14) Intestinal ischemia-reperfusion increases efflux for uric acid via paracellular route in the intestine, but decreases that via transcellular route mediated by Bcrp2012

Author(s)

Journal Title

URL

Data Source

[Presentation] 神経変性疾患におけるPDIのSNO化に対する抗酸化物質の脱修飾効果2023

Author(s)

Ogura Jiro 小倉次郎

OGURA Jiro 小倉次郎