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Ishibashi Mariko  石橋 真理子

Researcher Number 20599047
Other IDs
  • ORCIDhttps://orcid.org/0000-0001-8292-9283
Affiliation (Current) 2025: 日本医科大学, 医学部, 講師
Affiliation (based on the past Project Information) *help 2022 – 2025: 日本医科大学, 医学部, 講師
2017 – 2022: 日本医科大学, 医学部, 助教
2015: 日本医科大学, 大学院医学研究科, ポストドクター
Review Section/Research Field
Principal Investigator
Basic Section 50010:Tumor biology-related / Basic Section 49030:Experimental pathology-related / Hematology
Except Principal Investigator
Broad Section D / Basic Section 54010:Hematology and medical oncology-related / Hematology
Keywords
Principal Investigator
多発性骨髄腫 / 腫瘍免疫 / 腫瘍微小環境 / 免疫病態 / 腫瘍免疫微小環境 / 骨病変 / 抗腫瘍免疫 / 抗腫瘍免疫抑制 / Siglec-15 / 形質細胞 … More / 細胞増殖能 / 薬剤耐性 / 免疫関連分子 / 免疫治療 / 腫瘍悪性化 / ERKシグナル / CD229 / SLAMF3 … More
Except Principal Investigator
シンチレータ / 核医学 / SPECT / コンプトンカメラ / PET / galectin-3 / MUC1 / 予後不良因子 / KL-6 / 多発性骨髄腫 / 免疫抑制 / IL-2Rα / 腫瘍免疫 / 骨髄異形成症候群 / IL2Rα / CD25 / MDS Less
  • Research Projects

    (6 results)
  • Research Products

    (31 results)
  • Co-Researchers

    (10 People)
  •  Elucidating the diversity of the tumor immune microenvironment by characteristics of myeloma cellsPrincipal Investigator

    • Principal Investigator
      石橋 真理子
    • Project Period (FY)
      2025 – 2027
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 50010:Tumor biology-related
    • Research Institution
      Nippon Medical School
  •  骨髄微小環境におけるSiglec-15 を介した多発性骨髄腫の病態進展機序の解明Principal Investigator

    • Principal Investigator
      石橋 真理子
    • Project Period (FY)
      2022 – 2024
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 49030:Experimental pathology-related
    • Research Institution
      Nippon Medical School
  •  Whole gamma imaging to break through the physical limitation of positron emission tomography

    • Principal Investigator
      山谷 泰賀
    • Project Period (FY)
      2020 – 2024
    • Research Category
      Grant-in-Aid for Scientific Research (S)
    • Review Section
      Broad Section D
    • Research Institution
      National Institutes for Quantum Science and Technology
  •  Analysis of exacerbation mechanism by KL-6 and MUC1-galectin in multiple myeloma

    • Principal Investigator
      Tamura Hideto
    • Project Period (FY)
      2018 – 2020
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 54010:Hematology and medical oncology-related
    • Research Institution
      Dokkyo Medical University
      Nippon Medical School
  •  Molecular mechanism of immunoreceptor SLAMF3 in myeloma pathogenesis and development of new SLAMF3-targeted therapyPrincipal Investigator

    • Principal Investigator
      Ishibashi Mariko
    • Project Period (FY)
      2017 – 2019
    • Research Category
      Grant-in-Aid for Young Scientists (B)
    • Research Field
      Hematology
    • Research Institution
      Nippon Medical School
  •  New treatment strategy for myelodysplastic syndromes targeting the interleukin-2 receptor alpha-chain

    • Principal Investigator
      Onodera-Kondo Asaka
    • Project Period (FY)
      2013 – 2015
    • Research Category
      Grant-in-Aid for Young Scientists (B)
    • Research Field
      Hematology
    • Research Institution
      Nippon Medical School

All 2024 2023 2022 2021 2020 2019 2018 2017 2013

All Journal Article Presentation

  • [Journal Article] Serum soluble CD86 levels correlate with CD86 variant 3 gene expression and are prognostic indicators in myeloma2023

    • Author(s)
      Kinoshita R, Ishibashi M, Handa H, Sasaki M, Imai Y, Tanaka N, Ito S, Sunakawa-Kii M, Kaito Y, Asayama T, Komatsu N, Tanaka J, Odajima T, Sugimori H, Yamaguchi H, Inokuchi K, Tamura H.
    • Journal Title

      Experimental Hematology

      Volume: 121 Pages: 38-48

    • DOI

      10.1016/j.exphem.2023.01.006

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-20H05667, KAKENHI-PROJECT-20K08726, KAKENHI-PROJECT-20K02658, KAKENHI-PROJECT-23K07868
  • [Journal Article] Current and Future PET Imaging for Multiple Myeloma.2023

    • Author(s)
      Ishibashi M, Takahashi M, Yamaya T, Imai Y.
    • Journal Title

      Life

      Volume: 13 Issue: 8 Pages: 1701-1715

    • DOI

      10.3390/life13081701

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-22K07031, KAKENHI-PROJECT-20H05667
  • [Journal Article] 多発性骨髄腫の病態形成と骨髄免疫微小環境2023

    • Author(s)
      石橋真理子
    • Journal Title

      科学評論社 血液内科

      Volume: 86 Pages: 596-602

    • Data Source
      KAKENHI-PROJECT-22K07031
  • [Journal Article] Durvalumab Combined with Immunomodulatory Drugs (IMiD) Overcomes Suppression of Antitumor Responses due to IMiD-induced PD-L1 Upregulation on Myeloma Cells2021

    • Author(s)
      Ishibashi Mariko、Yamamoto Junichi、Ito Takumi、Handa Hiroshi、Sunakawa-Kii Mika、Inokuchi Koiti、Morita Rimpei、Tamura Hideto
    • Journal Title

      Molecular Cancer Therapeutics

      Volume: 20 Issue: 7 Pages: 1283-1294

    • DOI

      10.1158/1535-7163.mct-20-0246

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20H05667
  • [Journal Article] SLAMF3-mediated signaling via ERK pathway activation promotes aggressive myeloma behaviors in multiple myeloma.2020

    • Author(s)
      Ishibashi M, Takahashi R, Tsubota A, Sasaki M, Handa H, Imai Y, Tanaka N, Tsukune Y, Tanosaki S, Ito S, Asayama T, Sunakawa M, Kaito Y, Kuribayashi-Hamada Y, Kondo-Onodera A, Moriya K, Komatsu N, Tanaka J, Odajima T, Sugimori H, Inokuchi K, and Tamura H.
    • Journal Title

      Molecular Cancer Research

      Volume: 18 Issue: 4 Pages: 632-643

    • DOI

      10.1158/1541-7786.mcr-19-0391

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-17K09916, KAKENHI-PROJECT-17K16196
  • [Journal Article] 多発性骨髄腫におけるSLAMファミリー分子を標的とした治療2020

    • Author(s)
      Tamura H, Ishibashi M, Takahashi H, Inokuchi K
    • Journal Title

      臨床血液

      Volume: 61 巻 7 号 Pages: 827-831

    • NAID

      130007884756

    • Open Access
    • Data Source
      KAKENHI-PROJECT-17K16196
  • [Journal Article] Immunotherapy for Multiple Myeloma2019

    • Author(s)
      Tamura H, Ishibashi M, Sunakawa M, Inokuchi K
    • Journal Title

      Cancers (Basel)

      Volume: 11(12) Issue: 12 Pages: 2009-2009

    • DOI

      10.3390/cancers11122009

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-17K16196
  • [Journal Article] Clinical impact of serum soluble SLAMF7 in multiple myeloma.2018

    • Author(s)
      Ishibashi M, Soeda S, Sasaki M, Handa H, Imai Y, Tanaka N, Tanosaki S, Ito S, Odajima T, Sugimori H, Asayama T, Sunakawa M, Kaito Y, Kinoshita R, Kuribayashi Y, Onodera A, Moriya K, Tanaka J, Tsukune Y, Komatsu N, Inokuchi K, Tamura H.
    • Journal Title

      Oncotarget

      Volume: 9(78) Pages: 34784-34793

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-17K16196
  • [Presentation] The multiple myeloma microenvironment triggers inflammasome activation in tolerogenic dendritic cells to promote disease progression.2024

    • Author(s)
      Mariko Ishibashi, Mika Sunakawa, Rimpei Morita
    • Organizer
      第55回日本免疫学会学術集会
    • Data Source
      KAKENHI-PROJECT-22K07031
  • [Presentation] The multiple myeloma microenvironment triggers inflammasome activation in tolerogenic dendritic cells to promote disease progression.2024

    • Author(s)
      Mariko Ishibashi, Mika Sunakawa, Rimpei Morita.
    • Organizer
      第55回日本免疫学会学術集会
    • Data Source
      KAKENHI-PROJECT-20H05667
  • [Presentation] Immune Checkpoint Molecule Signaling and Immunotherapy in Myeloma2023

    • Author(s)
      Hideto Tamura, Mariko Ishibashi, Yoichi Imai
    • Organizer
      the 13th Japanese Society of Hematology (JSH) International Symposium
    • Invited
    • Data Source
      KAKENHI-PROJECT-20H05667
  • [Presentation] Characteristics of tolerogenic dendritic cells in multiple myeloma microenvironment2023

    • Author(s)
      Mariko Ishibashi
    • Organizer
      第81回日本癌学会学術集会
    • Data Source
      KAKENHI-PROJECT-22K07031
  • [Presentation] Tolerogenic dendritic cells alter the immune microenvironment in multiple myeloma.2023

    • Author(s)
      Mariko Ishibashi, Mika Sunakawa, Hideto Tamura, Rimpei Morita.
    • Organizer
      第85回日本血液学会学術集会
    • Data Source
      KAKENHI-PROJECT-20H05667
  • [Presentation] Immune Checkpoint Molecule Signaling and Immunotherapy in Myeloma.2023

    • Author(s)
      Hideto Tamura, Mariko Ishibashi, Yoichi Imai
    • Organizer
      The 13th Japanese Society of Hematology (JSH) International Symposium
    • Invited / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-22K07031
  • [Presentation] Aiming to improve bone marrow immune microenvironments in multiple myeloma2022

    • Author(s)
      Mariko Ishibashi
    • Organizer
      第47回日本骨髄腫学会学術集会
    • Invited
    • Data Source
      KAKENHI-PROJECT-22K07031
  • [Presentation] 未来PET創造研究ユニットが推進するB-to-C研究:頭部から全身へ2022

    • Author(s)
      山谷泰賀, 高橋美和子, 田島英朗, 赤松剛, 田久創大, 吉田英治, 黒澤俊介, 鎌田圭, 吉川彰, 羽石秀昭, 菅幹生, 川村和也, 石橋真理子, 今井陽一
    • Organizer
      第83回応用物理学会秋季学術講演会
    • Data Source
      KAKENHI-PROJECT-20H05667
  • [Presentation] Extracellular low pH in myeloma microenvironments induce tolerogenic dendritic cells.2022

    • Author(s)
      Mariko Ishibashi, Rimpei Morita
    • Organizer
      第54回日本免疫学会学術集会
    • Data Source
      KAKENHI-PROJECT-20H05667
  • [Presentation] Extracellular low pH and adenosine in myeloma microenvironments induce tolerogenic dendritic cells.2022

    • Author(s)
      Mariko Ishibashi, Rimpei Morita, Sunakawa Mika, Hideto Tamura.
    • Organizer
      第84回日本血液学会学術集会
    • Data Source
      KAKENHI-PROJECT-20H05667
  • [Presentation] 骨髄腫微小環境においてSiglec-15が抗腫瘍免疫と骨病変に及ぼす機能解析.2022

    • Author(s)
      石橋真理子
    • Organizer
      第90回日本医科大学医学会総会・学術集会
    • Data Source
      KAKENHI-PROJECT-22K07031
  • [Presentation] Aiming to improve bone marrow immune microenvironments in multiple myeloma.2022

    • Author(s)
      石橋真理子
    • Organizer
      第47回日本骨髄腫学会
    • Invited
    • Data Source
      KAKENHI-PROJECT-20H05667
  • [Presentation] Metabolic factors in myeloma microenvironments promote tolerogenic phenotypes in dendritic cells.2022

    • Author(s)
      Mariko Ishibashi, Hideto Tamura, Rimpei Morita.
    • Organizer
      第47回日本骨髄腫学会
    • Data Source
      KAKENHI-PROJECT-20H05667
  • [Presentation] Novel immune checkpoint sialic acid-binding Ig-like lectin (Siglec) family molecules in multiple myeloma2021

    • Author(s)
      Mariko Ishibashi, Hideto Tamura, Rimpei Morita
    • Organizer
      第46回日本骨髄腫学会
    • Invited
    • Data Source
      KAKENHI-PROJECT-20H05667
  • [Presentation] Myeloma microenvironments induce tolerogenic phenotypic behaviors in dendritic cells2021

    • Author(s)
      Mariko Ishibashi, Rimpei Morita
    • Organizer
      第53回日本免疫学会学術集会,
    • Data Source
      KAKENHI-PROJECT-20H05667
  • [Presentation] Induction of tolerogenic dendritic cells under myeloma microenvironment2021

    • Author(s)
      Mariko Ishibashi, Hideto Tamura, Rimpei Morita
    • Organizer
      第83回日本血液学会学術集会
    • Data Source
      KAKENHI-PROJECT-20H05667
  • [Presentation] 血清KL-6値は多発性骨髄腫の予後予測因子となりうる2019

    • Author(s)
      砂川 実香、田村 秀人、石橋 真理子ら
    • Organizer
      第44回日本骨髄腫学会
    • Data Source
      KAKENHI-PROJECT-18K08374
  • [Presentation] 血清KL-6値は多発性骨髄腫の予後予測因子となりうる2019

    • Author(s)
      砂川 実香、田村 秀人、石橋 真理子、海渡 裕太、木下 量介、朝山 敏夫、守屋 慶一、半田 寛、佐々木 純、今井 陽一、田中 紀奈、伊藤 薫樹、田野崎 栄、田中 淳司、小松則夫、猪口 孝一
    • Organizer
      第44回日本骨髄腫学会
    • Data Source
      KAKENHI-PROJECT-18K08374
  • [Presentation] The rs509749 genotype of the SLAMF3 gene is associated with multiple myeloma aggravation.2018

    • Author(s)
      Mariko Ishibashi, Hideto Tamura, Mika Sunakawa, Yuta Kaito, Ryosuke Kinoshita, Toshio Asayama, Keniich Moriya, Koiiti Inokuchi, Hidemi Takahashi
    • Organizer
      第80回日本血液学会学術集会
    • Data Source
      KAKENHI-PROJECT-17K16196
  • [Presentation] Pathophysiological functions and clinical impact of the new immunoreceptor SLAMF3 in multiple myeloma2017

    • Author(s)
      Mariko Ishibashi, Hideto Tamura, Toshio Asayama, Asaka Onodera, Keiichi Moriya, Makoto Sasaki, Hiroshi Handa, Yoichi Imai, Junji Tanaka, Sakae Tanosaki, Shigeki Ito, Norio Komatsu, Koiti Inokuchi
    • Organizer
      The 22nd European Hematology Association
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-17K16196
  • [Presentation] The new immunoreceptor SLAMF3 promotes aggressive biological and clinical characteristics in multiple myeloma2017

    • Author(s)
      Mariko Ishibashi, Hideto Tamura, Toshio Asayama, Yasuko Kuribayashi-hamada1, Asaka Onodera, Keiichi Moriya, Makoto Sasaki, Hiroshi Handa, Yoichi Imai, Norina Tanaka, Junji Tanaka, Sakae Tanosaki, Shigeki Ito, Norio Komatsu, Koiti Inokuchi
    • Organizer
      59th american society of hematology (ash) annual meeting & exposition
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-17K16196
  • [Presentation] Mechanism of multiple myeloma aggravation mediated by immunoreceptor SLAMF3 molecules2017

    • Author(s)
      石橋真理子、田村秀人、髙橋理紗、坪田朝子、朝山敏夫、栗林(濱田)泰子、小野寺麻加、守屋慶一、今井陽一、半田寛、佐々木純、小松則夫、田野崎栄、伊藤薫樹、猪口 孝一
    • Organizer
      第42回日本骨髄腫学会学術集会
    • Data Source
      KAKENHI-PROJECT-17K16196
  • [Presentation] Clinical significance of the interleukin-2 receptor α-chain expressed by blasts in myelodysplastic syndromes2013

    • Author(s)
      Mariko Ishibashi, Hideto Tamura and Kiyoyuki Ogata
    • Organizer
      The 12th International Symposium on Myelodysplastic Syndromes
    • Place of Presentation
      Berlin, Germany
    • Data Source
      KAKENHI-PROJECT-25860795
  • 1.  Tamura Hideto (70256949)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 3 results
  • 2.  Onodera-Kondo Asaka (80468769)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 3.  山谷 泰賀 (40392245)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 1 results
  • 4.  吉川 彰 (50292264)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 1 results
  • 5.  菅 幹生 (00294281)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 1 results
  • 6.  今井 陽一 (10345209)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 4 results
  • 7.  永津 弘太郎 (30531529)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 8.  高橋 美和子 (00529183)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 1 results
  • 9.  吉田 英治 (50392246)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 1 results
  • 10.  田島 英朗 (70572907)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 1 results

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