TSUJITA TADAYUKI 辻田忠志

… Alternative Names

Tsujita Tadayuki 辻田忠志

TSUJITA Tadayuki 辻田忠志

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Researcher Number	20622046
Other IDs	https://orcid.org/0000-0002-7189-0376
Affiliation (Current)	2024: 佐賀大学, 農学部, 准教授
Affiliation (based on the past Project Information) *help	2022 – 2024: 佐賀大学, 農学部, 准教授 2016 – 2023: 佐賀大学, 農学部, 講師 2013 – 2014: 東北大学, 医学(系)研究科(研究院), 助教
Review Section/Research Field	Principal Investigator Basic Section 59040:Nutrition science and health science-related / Applied health science / Medium-sized Section 59:Sports sciences, physical education, health sciences, and related fields / Health science and related fields Except Principal Investigator Basic Section 38010:Plant nutrition and soil science-related / Basic Section 58020:Hygiene and public health-related: including laboratory approach
Keywords	Principal Investigator Nrf1 / 老化 / 酸化ストレス / ポリアミン / 低酸素 / ストレス / スペルミジンオキシだーぜ / 不良タンパク質蓄積 / リポソームコリジョン / アクロレイン … More / PHD-HIF系 / 低分子化合物 / 低酸素応答 / HIF / PHD / 代謝異常 / ERストレス / アミノ酸代謝 / Nrf1/2 / 代謝 / 転写因子 / 酸素 / 安全性試験 / 初代培養 / 肝細胞 / レドックスバランス / 加齢・老化 / グルタチオン / NRF1 / 還元ストレス … More Except Principal Investigator 栄養応答 / 無機栄養 / シロイヌナズナ / 選択的スプライシング / カリウム / polymorphism / 飲酒 / バイオマーカー / メラノーシス / メラノーマ / アセトアルデヒド / エタノール / メラニン / 発がん / アルデヒド / 遺伝子多型 / ALDH2 Less

New strategic approach for ameliorate hypoxic injury using the PHD1 specific inhibitor and definition of the molecular mechanism.Principal Investigator
- Principal Investigator
  
  辻田忠志
- Project Period (FY)
  2022 – 2024
- Research Category
  
  Grant-in-Aid for Challenging Research (Exploratory)
- Review Section
  
  Medium-sized Section 59:Sports sciences, physical education, health sciences, and related fields
- Research Institution
  Saga University
Molecular mechanisms of the alternative splicing regulation in response to a variable nutrient environment in plants
- Principal Investigator
  
  西田翔
- Project Period (FY)
  2022 – 2025
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 38010:Plant nutrition and soil science-related
- Research Institution
  Saga University
Controlling the anti aging mechanism through modification of the protein translation pathway and Amine metabolizing pathwayPrincipal Investigator
- Principal Investigator
  
  辻田忠志
- Project Period (FY)
  2022 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 59040:Nutrition science and health science-related
- Research Institution
  Saga University
Alcohol and rs671 on melanoma development: an experimental approach
- Principal Investigator
  
  松本明子
- Project Period (FY)
  2021 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 58020:Hygiene and public health-related: including laboratory approach
- Research Institution
  Saga University
Controlling the aging and metabolic process with anti-stress enzyme expression profiles through those controlling transcriptional factor, Nrf1Principal Investigator
- Principal Investigator
  
  TSUJITA Tadayuki
- Project Period (FY)
  2019 – 2021
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 59040:Nutrition science and health science-related
- Research Institution
  Saga University
Development the culture method for primary hepatocyte to keeping a same response range in vitro and in vivo for exogenous stimulus.Principal Investigator
- Principal Investigator
  
  Tsujita Tadayuki
- Project Period (FY)
  2017 – 2019
- Research Category
  
  Grant-in-Aid for Challenging Research (Exploratory)
- Research Field
  
  Health science and related fields
- Research Institution
  Saga University
Modulation and/or controlling of the aging event by the basic anti-oxidative response with environmental transcriptional factor Nrf1Principal Investigator
- Principal Investigator
  
  Tsujita Tadayuki
- Project Period (FY)
  2016 – 2018
- Research Category
  
  Grant-in-Aid for Young Scientists (A)
- Research Field
  
  Applied health science
- Research Institution
  Saga University
Does adjusting Nrf1 active status lead to remediate reductive stress and aging-related diseases?Principal Investigator
- Principal Investigator
  
  TSUJITA Tadayuki
- Project Period (FY)
  2013 – 2014
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Applied health science
- Research Institution
  Tohoku University

All 2022 2021 2020 2019 2018 2017 2016 2015 2014 Other

All Journal Article Presentation Book Patent

[Book] 酸化ストレス認識分子基盤と創薬応用」生命科学から創薬へのイノベーション2014
- Author(s)
  辻田忠志, 山本雅之
- Total Pages
  202
- Publisher
  南山堂
- Data Source
  KAKENHI-PROJECT-25750357
[Journal Article] Improving lipophilicity of 5-(1-acetyl-5-phenylpyrazolidin-3-ylidene)-1,3-dimethylbarbituric acid increases its efficacy to activate hypoxia-inducible factors2022
- Author(s)
  Sonoda Kento、Ujike Saki、Katayama Akito、Suzuki Norio、Kawaguchi Shin-ichi、Tsujita Tadayuki
- Journal Title
  
  Bioorganic and Medicinal Chemistry
  
  Volume: 73 Pages: 117039-117039
- DOI
  10.1016/j.bmc.2022.117039
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-22K19396, KAKENHI-PROJECT-22K19755, KAKENHI-PROJECT-23K21372
[Journal Article] Prolyl Hydroxylase Domain Protein Inhibitor Not Harboring a 2-Oxoglutarate Scaffold Protects against Hypoxic Stress2022
- Author(s)
  Kento Sonoda , Sudarma Bogahawatta, Akito Katayama, Saki Ujike, Sae Kuroki, Naho Kitagawa, Kohichi Hirotsuru, Norio Suzuki, Toshio Miyata, Shin-ichi Kawaguchi, and Tadayuki Tsujita*
- Journal Title
  
  ACS Pharmacol. Transl. Sci.
  
  Volume: 5 Issue: 5 Pages: 362-372
- DOI
  10.1021/acsptsci.2c00002
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K17746, KAKENHI-PROJECT-22K19396, KAKENHI-PROJECT-22K19755, KAKENHI-PROJECT-23K21372
[Journal Article] Anti-Fibrotic and Anti-Angiogenic Activities of Osbeckia octandra Leaf Extracts in Thioacetamide-Induced Experimental Liver Cirrhosis2021
- Author(s)
  Bogahawaththa Sudarma、Kodithuwakku Suranga P.、Wijesundera Kavindra K.、Siriweera Eranga H.、Jayasinghe Lalith、Dissanayaka Waruna L.、Rajapakse Jayanthe、Herath Chandana B.、Tsujita Tadayuki、Wijayagunawardane Missaka P. B.
- Journal Title
  
  Molecules
  
  Volume: 26 Issue: 16 Pages: 4836-4836
- DOI
  10.3390/molecules26164836
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19H04057
[Journal Article] Furan- and Thiophene-2-Carbonyl Amino Acid Derivatives Activate Hypoxia-Inducible Factor via Inhibition of Factor Inhibiting Hypoxia-Inducible Factor-12018
- Author(s)
  Kawaguchi Shin-Ichi, Gonda Yuhei, Yamamoto Takuya, Sato Yuki, Shinohara Hiroyuki, Kobiki Yohsuke, Ichimura Atsuhiko, Dan Takashi, Sonoda Motohiro, Miyata Toshio, Ogawa Akiya, Tsujita Tadayuki
- Journal Title
  
  Molecules
  
  Volume: 23 Issue: 4 Pages: 885-885
- DOI
  10.3390/molecules23040885
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-16H04138, KAKENHI-PROJECT-15H05652, KAKENHI-PROJECT-16K14049, KAKENHI-PROJECT-17K19916, KAKENHI-PROJECT-16H05922, KAKENHI-PROJECT-17K19881
[Journal Article] O-GlcNAcylation Signal Mediates Proteasome Inhibitor Resistance in Cancer Cells by Stabilizing NRF12018
- Author(s)
  Sekine Hiroki、Okazaki Keito、Kato Koichiro、Alam M. Morshedul、Shima Hiroki、Katsuoka Fumiki、Tsujita Tadayuki、Suzuki Norio、Kobayashi Akira、Igarashi Kazuhiko、Yamamoto Masayuki、Motohashi Hozumi
- Journal Title
  
  Molecular and Cellular Biology
  
  Volume: 38 Issue: 17 Pages: 00252-18
- DOI
  10.1128/mcb.00252-18
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K07278, KAKENHI-PROJECT-17K19680, KAKENHI-PROJECT-17K19916, KAKENHI-PUBLICLY-18H04794, KAKENHI-PROJECT-18H04021, KAKENHI-PROJECT-15H04691, KAKENHI-PROJECT-16H03265, KAKENHI-PROJECT-18H02621, KAKENHI-PROJECT-16H05922, KAKENHI-PROJECT-17F17116, KAKENHI-PROJECT-17K19508, KAKENHI-PROJECT-17K08618
[Journal Article] Nrf2 activation attenuates genetic endoplasmic reticulum stress induced by a mutation in the phosphomannomutase 2 gene in zebrafish2018
- Author(s)
  Mukaigasa Katsuki、Tsujita Tadayuki、Nguyen Vu Thanh、Li Li、Yagi Hirokazu、Fuse Yuji、Nakajima-Takagi Yaeko、Kato Koichi、Yamamoto Masayuki、Kobayashi Makoto
- Journal Title
  
  Proc. Natl. Acad. Sci.
  
  Volume: 115 Issue: 11 Pages: 2758-2763
- DOI
  10.1073/pnas.1714056115
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-ORGANIZER-25102001, KAKENHI-PLANNED-25102008, KAKENHI-PROJECT-16H05922, KAKENHI-PROJECT-17J04162, KAKENHI-PROJECT-26520101
[Journal Article] A ubiquitin-proteasome inhibitor bortezomib suppresses the expression of CYP11B2, a key enzyme of aldosterone synthesis2017
- Author(s)
  Ito Ryo、Sato Ikuko、Tsujita Tadayuki、Yokoyama Atsushi、Sugawara Akira
- Journal Title
  
  Biochem Biophys Res Commun
  
  Volume: 489 Issue: 1 Pages: 21-28
- DOI
  10.1016/j.bbrc.2017.05.109
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-16K08606, KAKENHI-PROJECT-17K19916, KAKENHI-PROJECT-16H05922, KAKENHI-PROJECT-16K19550
[Journal Article] Homeostatic Shift Facilitates Endoplasmic Reticulum Proteostasis through Transcriptional Integration of Proteostatic Stress Response Pathways.2017
- Author(s)
  Baird L, Tsujita T, Kobayashi E, Funayama R, Nagashima T, Nakayama K, and Yamamoto M.
- Journal Title
  
  Mol Cell Biol
  
  Volume: 37 Issue: 4
- DOI
  10.1128/mcb.00439-16
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-16H05922, KAKENHI-PROJECT-26293059, KAKENHI-PROJECT-16K14664
[Journal Article] Time-resolved Fluorescent Detection for Glucose Using a Complex of Luminescent Layered Titanates and Enzymes2017
- Author(s)
  SAKAGUCHI Yuki、MINAMIKAWA Tomoka、YAMAMURO Mayuko、TSUJITA Tadayuki、UEDA Toshihisa、KAMADA Kai、SOH Nobuaki
- Journal Title
  
  Anal. Sci.
  
  Volume: 33 Issue: 9 Pages: 989-991
- DOI
  10.2116/analsci.33.989
- NAID
  130006071189
- ISSN
  0910-6340, 1348-2246
- Language
  English
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K19916, KAKENHI-PROJECT-16H05922, KAKENHI-PROJECT-15K05542
[Journal Article] Halofuginone enhances the chemo-sensitivity of cancer cells by suppressing NRF2 accumulation.2017
- Author(s)
  Tsuchida K, Tsujita T, Hayashi M, Ojima A, Keleku-Lukwete N, Katsuoka F, Otsuki A, Kikuchi H, Oshima Y, Suzuki M, Yamamoto M.
- Journal Title
  
  Free Radic Biol Med
  
  Volume: 103 Pages: 236-247
- DOI
  10.1016/j.freeradbiomed.2016.12.041
- Peer Reviewed / Acknowledgement Compliant / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PLANNED-26111002, KAKENHI-PROJECT-16H05922, KAKENHI-PROJECT-16H06639, KAKENHI-PROJECT-16H07149, KAKENHI-PROJECT-26461395
[Journal Article] Induction of erythropoietin gene expression in epithelial cells by chemicals identified in GATA inhibitor screenings2017
- Author(s)
  Kaneko Hiroshi、Katoh Takehide、Hirano Ikuo、Hasegawa Atsushi、Tsujita Tadayuki、Yamamoto Masayuki、Shimizu Ritsuko
- Journal Title
  
  Genes Cells
  
  Volume: 22 Issue: 11 Pages: 939-952
- DOI
  10.1111/gtc.12537
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K19916, KAKENHI-PROJECT-16H05922
[Journal Article] Intracellular thiol contents and fatty acid metabolism pathways are regulated by the Nrf1 (NFE2L1) with its transcriptional suppressor activity2016
- Author(s)
  辻田忠志
- Journal Title
  
  生化学
  
  Volume: 88 Issue: 6 Pages: 776-781
- DOI
  10.14952/SEIKAGAKU.2016.880776
- NAID
  40021054408
- ISSN
  0037-1017
- Year and Date
  2016-12-25
- Language
  Japanese
- Data Source
  KAKENHI-PROJECT-16H05922
[Journal Article] Discovery of an NRF1-specific inducer from a large-scale chemical library using a direct NRF1-protein monitoring system.2015
- Author(s)
  Tsujita T, Baird L, Furusawa Y, Katsuoka F, Hou Y, Gotoh S, Kawaguchi S-i, and Yamamoto M.
- Journal Title
  
  Genes Cells
  
  Volume: 7 Issue: 7 Pages: 563-577
- DOI
  10.1111/gtc.12248
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-25750357, KAKENHI-PROJECT-26860168
[Journal Article] Dnmt3a regulates osteoclast differentiation by coupling to an S-adenosyl methionine-producing metabolic pathway.2015
- Author(s)
  Nishikawa et al.
- Journal Title
  
  Nature Medicine
  
  Volume: 21 Issue: 3 Pages: 281-287
- DOI
  10.1038/nm.3774
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PLANNED-22113007, KAKENHI-PROJECT-24249015, KAKENHI-PROJECT-25293423, KAKENHI-PROJECT-25670792, KAKENHI-PROJECT-25750357, KAKENHI-PLANNED-26111002, KAKENHI-PUBLICLY-26116719, KAKENHI-PROJECT-26670673, KAKENHI-PROJECT-26713010, KAKENHI-PROJECT-25253070
[Journal Article] Hypoxia-Sensitive Reporter System for High-Throughput Screening2015
- Author(s)
  Tsujita, T.; Kawaguchi, S-i.; Dan, T.; Baird, L.; Miyata, T.; Yamamoto, M.
- Journal Title
  
  Tohoku J. Exp. Med.
  
  Volume: 235 Issue: 2 Pages: 151-159
- DOI
  10.1620/tjem.235.151
- NAID
  130004822440
- ISSN
  0040-8727, 1349-3329
- Language
  English
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-12J05784, KAKENHI-PROJECT-24249015, KAKENHI-PROJECT-25750357, KAKENHI-PLANNED-26111002, KAKENHI-PROJECT-26860168
[Journal Article] Transcription factor NF-E2-related factor 1 impairs glucose metabolism in mice.2014
- Author(s)
  Hirotsu Y, Higashi C, Fukutomi T, Katsuoka F, Tsujita T, Yagishita Y, Matsuyama Y, Motohashi H, Uruno A, and Yamamoto M.
- Journal Title
  
  Mol Cell Biol
  
  Volume: 19 Issue: 8 Pages: 650-665
- DOI
  10.1111/gtc.12165
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PLANNED-23116002, KAKENHI-PROJECT-24249015, KAKENHI-PROJECT-24390075, KAKENHI-PROJECT-25750357, KAKENHI-PROJECT-26460383, KAKENHI-PROJECT-26670150, KAKENHI-PROJECT-26893008
[Journal Article] Transcription factor Nrf1 negatively regulates the cystine/glutamate transporter and lipid-metabolizing enzymes2014
- Author(s)
  Tsujita T, Peirce V, Baird L, Matsuyama Y, Takaku M, Walsh SV, Griffin JL, Uruno A, Yamamoto M, and Hayes JD.
- Journal Title
  
  Mol Cell Biol
  
  Volume: 34 Issue: 20 Pages: 3800-3816
- DOI
  10.1128/mcb.00110-14
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-24249015, KAKENHI-PROJECT-25750357, KAKENHI-PLANNED-26111002, KAKENHI-PROJECT-26460383
[Journal Article] Loss of Nrf2 in mice evokes a congenital intrahepatic shunt that alters hepatic oxygen and protein expression gradients and toxicity.2014
- Author(s)
  Skoko JJ, Wakabayashi N, Noda K, Kimura S, Tobita K, Shigemura N, Tsujita T, Yamamoto M, and Kensler TW.
- Journal Title
  
  Toxicol Sci
  
  Volume: 141 Issue: 1 Pages: 112-119
- DOI
  10.1093/toxsci/kfu109
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-25750357
[Patent] 新規な含窒素環状化合物及びその用途2020
- Inventor(s)
  川口真一, 辻田忠志
- Industrial Property Rights Holder
  佐賀大学
- Industrial Property Rights Type
  特許
- Industrial Property Number
  2020-174971
- Filing Date
  2020
- Data Source
  KAKENHI-PROJECT-19H04057
[Presentation] Nrf1タンパク質量を調節する小胞体逆輸送機構の解析2022
- Author(s)
  山田剛暉, 馬禎珠, 田上愛祐美, 平川智章, ボガハワッタスダーマ, 川村友秋, 辻田忠志.
- Organizer
  第95回日本生化学会大会
- Data Source
  KAKENHI-PROJECT-23K24772
[Presentation] Hep3B細胞におけるKlothoノックダウンがアミノ酸飢餓応答とNrf1に与える影響2022
- Author(s)
  川村友秋, Sudarma Bogahawaththa, 志賀奏, 辻田忠志
- Organizer
  第44回蛋白質と酵素の構造と機能に関する九州シンポジウム
- Data Source
  KAKENHI-PROJECT-23K24772
[Presentation] Nrf1 Upregulation Influence on Cellular Glucose Deficiency; using Stably Expressed Nrf1 Tet-on system2022
- Author(s)
  Shanika Werellagama, Megumi Matsumoto, Mami Sato, Kento Sonoda, Tomoaki Kawamura, Marcus Conrad, Tadayuki Tsujita
- Organizer
  第95回日本生化学会大会
- Data Source
  KAKENHI-PROJECT-23K24772
[Presentation] 新たな骨格を持つPHD活性阻害剤PyrzAの創出と構造活性相関研究2022
- Author(s)
  辻田忠志, 園田健登, 氏家沙綺, 片山彰人, 鈴木教郎川口真一
- Organizer
  第18回がんとハイポキシア研究会
- Data Source
  KAKENHI-PROJECT-22K19755
[Presentation] Identification of a Novel Aging Controller and its Competitors in an Aging Mouse Model2022
- Author(s)
  Sudarma Bogahawaththa, Tomoaki Kawamura, Kanade Shiga, Yo-Ichi Nabeshima, Ken Itoh, Tadayuki Tsujita
- Organizer
  第95回日本生化学会大会
- Data Source
  KAKENHI-PROJECT-23K24772
[Presentation] 転写因子Nrf1によるステロイド5αリダクターゼの調節解析2022
- Author(s)
  マジョンジュ, 山田剛暉, 平川智章, Bogahawaththa Sudarma, 川村友秋, 下村隆, 辻田忠志.転写因子Nrf1によるステロイド5αリダクターゼの調節解析
- Organizer
  第95回日本生化学会大会
- Data Source
  KAKENHI-PROJECT-23K24772
[Presentation] タンパク質恒常性の維持・老化と関連する環境転写因子Nrf1の解析2022
- Author(s)
  辻田忠志
- Organizer
  佐賀大学SDGsプロジェクト研究所「皮膚科学に関する知の拠点形成プロジェクト」第一回シンポジウム
- Invited
- Data Source
  KAKENHI-PROJECT-23K24772
[Presentation] タンパク質恒常性の維持・老化と関連する環境転写因子Nrf1の解析2022
- Author(s)
  辻田忠志
- Organizer
  佐賀大学SDGsプロジェクト研究所「皮膚科学に関する知の拠点形成プロジェクト」第一回シンポジウム
- Invited
- Data Source
  KAKENHI-PROJECT-22K19755
[Presentation] 新規Nrf1標的遺伝子Smoxとアクロレイン産生機序の解明2022
- Author(s)
  平川智章, 谷内めぐみ, 井口瑶子, 吉竹紀子, 植村武史, 辻田忠志
- Organizer
  第44回蛋白質と酵素の構造と機能に関する九州シンポジウム
- Data Source
  KAKENHI-PROJECT-23K24772
[Presentation] 低酸素ストレスから防御する新奇HIF活性化剤PyrzAの発見2022
- Author(s)
  園田健登, 片山彰人, 氏家沙綺, 黒木紗英, 北川尚穂, 廣津留倖一, 川口真一, 辻田忠志
- Organizer
  第95回日本生化学会大会.
- Data Source
  KAKENHI-PROJECT-22K19755
[Presentation] ストレス応答性転写因子Nrf1によるアミノ酸の取込および感知機構の制御2021
- Author(s)
  辻田忠志
- Organizer
  12回トランスポーター研究会九州部会・シンポジウム
- Invited
- Data Source
  KAKENHI-PROJECT-19H04057
[Presentation] 含硫化合物が起点となる細胞内ストレス耐性機構の調節2021
- Author(s)
  辻田忠志
- Organizer
  第94回日本生化学大会　・シンポジウム「含硫化合物・温故知新―生物多様性に学ぶ含硫代謝物の多彩な生理作用」
- Invited
- Data Source
  KAKENHI-PROJECT-19H04057
[Presentation] Smox過剰発現によるポリアミンインバランス誘導と内因的に発生するアクロレインの評価2020
- Author(s)
  平川智章, 辻田忠志
- Organizer
  第93回日本生化学会大会
- Data Source
  KAKENHI-PROJECT-19H04057
[Presentation] Nrf1欠失細胞における外来ストレス応答度の変化と分子メカニズム解析2020
- Author(s)
  松本めぐみ, 辻田忠志
- Organizer
  第93回日本生化学会大会
- Data Source
  KAKENHI-PROJECT-19H04057
[Presentation] ポリアミン代謝の不均衡による内因性アクロレインの発生と肝疾患2019
- Author(s)
  辻田忠志.
- Organizer
  第４２回日本分子生物学会年会, フォーラム
- Invited
- Data Source
  KAKENHI-PROJECT-19H04057
[Presentation] Discovering the sunny and dark side of Nrf1 transcriptional factor and its utilization2019
- Author(s)
  Tadayuki Tsujita
- Organizer
  31st annual congress of the PGIA
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19H04057
[Presentation] Accumulation of the acrolein conjugated protein in Nrf1 knockout mice and cellular model.2019
- Author(s)
  Tadayuki Tsujita, Megumi Taniuchi, Tomoaki Hirakawa, Minami Kudo, Megumi Matsumoto, Kanade Shiga
- Organizer
  The Environmental response V
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19H04057
[Presentation] 早期老化α-Klotho-/-マウスおよび加齢マウスを用いた老化指標の探索2019
- Author(s)
  志賀奏, 辻田忠志
- Organizer
  第43回蛋白質と酵素の構造と機能に関する九州シンポジウム
- Data Source
  KAKENHI-PROJECT-19H04057
[Presentation] Discovering the sunny and dark side of Nrf1 transcriptional factor and its utilization2019
- Author(s)
  Tadayuki Tsujita
- Organizer
  31st annual congress of the PGIA
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K19916
[Presentation] 肝特異的Nrf1欠失マウスにおけるNAFLDとアクロレイン化タンパク質の関連解析2018
- Author(s)
  谷内めぐみ, 井口瑶子, 辻田忠志.
- Organizer
  日本ポリアミン学会第10回年会
- Data Source
  KAKENHI-PROJECT-16H05922
[Presentation] PHDタンパク質にアロステリックに作用し、低酸素応答因子HIFを安定化する新規化合物の探索2018
- Author(s)
  園田健登, 廣津留倖一, 北川尚穂, 川口真一, 辻田忠志
- Organizer
  第91回日本生化学会大会
- Data Source
  KAKENHI-PROJECT-16H05922
[Presentation] PHDタンパク質にアロステリックに作用し、低酸素応答因子HIFを安定化する新規化合物の探索.2018
- Author(s)
  園田健登, 廣津留倖一, 北川尚穂, 川口真一, 辻田忠志
- Organizer
  第91回日本生化学会大会. 国立京都国際会館
- Data Source
  KAKENHI-PROJECT-17K19916
[Presentation] 転写因子Nrf1による生体恒常性維持機構の解明2018
- Author(s)
  辻田忠志
- Organizer
  第32回HiHA（広島大学健康長寿研究拠点）セミナー
- Invited
- Data Source
  KAKENHI-PROJECT-16H05922
[Presentation] 分子選択的なHIF活性化低分子化合物の開発2018
- Author(s)
  黒木紗英, 辻田忠志, 川口真一
- Organizer
  第42回蛋白質と酵素の構造と機能に関する九州シンポジウム
- Data Source
  KAKENHI-PROJECT-17K19916
[Presentation] HIF分解を制御するPHDタンパク質をアロステリックに阻害する新規化合物の探索.2018
- Author(s)
  園田健登, 廣津留倖一, 北川尚穂, 川口真一, 辻田忠志
- Organizer
  平成 30年度日本生化学会九州支部例会
- Data Source
  KAKENHI-PROJECT-17K19916
[Presentation] HIF分解を制御するPHDタンパク質をアロステリックに阻害する新規化合物の探索2018
- Author(s)
  園田健登, 廣津留倖一, 北川尚穂, 川口真一, 辻田忠志.
- Organizer
  平成 30年度日本生化学会九州支部例会
- Data Source
  KAKENHI-PROJECT-16H05922
[Presentation] アロステリックなPHD活性阻害によるHIF誘導低分子化合物の創出.2017
- Author(s)
  廣津留倖一, 北川尚穂, 川口真一, 辻田忠志
- Organizer
  第41回蛋白質と酵素の構造と機能に関する九州シンポジウム
- Data Source
  KAKENHI-PROJECT-17K19916
[Presentation] Functional analysis and advanced application for drug discovery with environmental response transcriptional factors2017
- Author(s)
  辻田忠志
- Organizer
  第６回脳科学セミナー
- Invited
- Data Source
  KAKENHI-PROJECT-17K19916
[Presentation] ストレス応答転写因子Nrf1を特異的に安定化する誘導剤の探索.2017
- Author(s)
  福元雄大, 辻田忠志, 川口真一.
- Organizer
  2017年度生命科学系学会合同年次大会
- Data Source
  KAKENHI-PROJECT-16H05922
[Presentation] リガンド2OGの構造に基づいた分子設計による低酸素誘導因子の活性化2017
- Author(s)
  黒木紗英, 辻田忠志, 川口真一
- Organizer
  第41回蛋白質と酵素の構造と機能に関する九州シンポジウム
- Data Source
  KAKENHI-PROJECT-17K19916
[Presentation] ストレス応答転写因子Nrf1を特異的に活性化する誘導剤の探索.2017
- Author(s)
  福元雄大, 辻田忠志.
- Organizer
  平成 29年度日本生化学会九州支部例会
- Data Source
  KAKENHI-PROJECT-16H05922
[Presentation] 唐津地産抽出物ライブラリーに含まれる有効成分の培養細胞による評価抗酸化活性を評価できるモニター細胞の創出とその応用2017
- Author(s)
  辻田忠志
- Organizer
  第5回JCC産学交流セミナー
- Invited
- Data Source
  KAKENHI-PROJECT-17K19916
[Presentation] Possible link and future direction between stress transcriptional factor Nrf1/2 and NGLY12017
- Author(s)
  Tadayuki TSUJITA
- Organizer
  4th Global NGLY1 Conference
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16H05922
[Presentation] 環境転写因子Nrf1を特異的に活性化する化合物の探索2016
- Author(s)
  廣津留倖一, 川口真一, 山本雅之, 辻田忠志.
- Organizer
  第40回蛋白質と酵素の構造と機能に関する九州シンポジウム
- Place of Presentation
  指宿
- Year and Date
  2016-08-26
- Data Source
  KAKENHI-PROJECT-16H05922
[Presentation] 転写因子NRF1のOGT-HCF-1複合体を介した分解制御機構2016
- Author(s)
  関根弘樹, 加藤幸一郎, 福田愛菜, 鈴木教郎, 岡崎慶斗, アラムモシェッド. 辻田忠志, 小林聡, 山本雅之, 本橋ほづみ
- Organizer
  第89回日本生化学会大会
- Place of Presentation
  仙台
- Year and Date
  2016-09-25
- Data Source
  KAKENHI-PROJECT-16H05922
[Presentation] Nrf1タンパク質の活性化状態を直接モニターできるレポーター培養細胞による大規模化合物スクリーニングとNrf1に特異的な活性化化合物の創出2016
- Author(s)
  辻田忠志, Liam Baird, 古澤祐樹, 勝岡史樹, 彭よしか, 後藤智美, 川口真一, 山本雅之.
- Organizer
  第89回日本生化学会大会
- Place of Presentation
  仙台
- Year and Date
  2016-09-25
- Data Source
  KAKENHI-PROJECT-16H05922
[Presentation] Transcription factor Nrf1 negatively regulates the cystine transporter and lipid metabolic enzymes to prevent over-nutrition in hepatocytes2014
- Author(s)
  Tsujita T, Mullin V, Baird L, Matsuyama Y，Takaku M，Walsh SV，Griffin JL，Yamamoto M and Hayes JD
- Organizer
  17th Biennial Meeting of Society for Free Radical Research International (SFRRI2014)
- Place of Presentation
  Kyoto, Japan
- Data Source
  KAKENHI-PROJECT-25750357
[Presentation] Transcription factor Nrf1 negatively regulates the cystine/glutamate transporter and lipid-metabolizing enzymes2014
- Author(s)
  Tsujita T, Mullin V, Baird L, Matsuyama Y，Takaku M，Walsh SV，Griffin JL，Yamamoto M and Hayes JD
- Organizer
  The Environmental Response IV
- Place of Presentation
  Sendai, Japan
- Data Source
  KAKENHI-PROJECT-25750357
[Presentation] 転写因子Nrf1はシステイン・グルタミントランスポーターおよび脂質代謝酵素群を抑制制御する
- Author(s)
  辻田忠志, Vivian Mullin, Liam Baird, 松山由香, 高久美咲, Shawn Walsh, Julian Griffin, 山本雅之, John Hayes
- Organizer
  第25回日本生化学会大会
- Place of Presentation
  京都国際会館（京都市）
- Year and Date
  2014-10-15 – 2014-10-18
- Data Source
  KAKENHI-PROJECT-25750357
[Presentation] 転写因子Nrf1はシステイントランスポーターおよび脂質代謝酵素群を抑制制御する
- Author(s)
  辻田忠志, Vivian Mullin, Liam Baird, 松山由香, 高久美咲, Shawn Walsh, Julian Griffin, 山本雅之, John Hayes.
- Organizer
  第25回日本生体防御学会学術総会
- Place of Presentation
  さくらホール（仙台市）
- Year and Date
  2014-07-09 – 2014-07-11
- Data Source
  KAKENHI-PROJECT-25750357
[Presentation] 転写因子Nrf1はシステイントランスポーターおよび脂質代謝酵素群を抑制制御する
- Author(s)
  辻田忠志
- Organizer
  第56回脳研・高度先進合同セミナー（『心の遺伝子』研究コンソーシアム研究セミナー）
- Place of Presentation
  青森県・弘前市・弘前大学医学部
- Invited
- Data Source
  KAKENHI-PROJECT-25750357

1. 水沼正樹 (10343295)

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2. 山本雄広 (50383774)

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3. 川口真一 (00722894)

# of Collaborated Projects: 1 results

# of Collaborated Products: 3 results
4. 伴匡人 (00579667)

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5. 松本明子 (10330979)

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6. 鈴木民夫 (30206502)

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7. 伊藤祥輔 (70121431)

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8. 若松一雅 (80131259)

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9. 原俊哉 (70274602)

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10. 西田翔 (40647781)

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11. 伊東健 (10323289)

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12. 植村武史 (50401005)

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13. SUZUKI Norio

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# of Collaborated Products: 2 results
14. YOKOYAMA Atsushi

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15. SUGAWARA akira

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16. SHIMA Hiroki

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17. 小川昭弥

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18. 本橋ほづみ

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19. 山本雅之

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20. 宇留野晃

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21. 加藤晃一

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TSUJITA TADAYUKI 辻田 忠志

Tsujita Tadayuki 辻田 忠志

TSUJITA Tadayuki 辻田 忠志

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Co-Researchers

New strategic approach for ameliorate hypoxic injury using the PHD1 specific inhibitor and definition of the molecular mechanism.Principal Investigator

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Molecular mechanisms of the alternative splicing regulation in response to a variable nutrient environment in plants

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Controlling the anti aging mechanism through modification of the protein translation pathway and Amine metabolizing pathwayPrincipal Investigator

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Alcohol and rs671 on melanoma development: an experimental approach

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Controlling the aging and metabolic process with anti-stress enzyme expression profiles through those controlling transcriptional factor, Nrf1Principal Investigator

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Development the culture method for primary hepatocyte to keeping a same response range in vitro and in vivo for exogenous stimulus.Principal Investigator

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Modulation and/or controlling of the aging event by the basic anti-oxidative response with environmental transcriptional factor Nrf1Principal Investigator

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Does adjusting Nrf1 active status lead to remediate reductive stress and aging-related diseases?Principal Investigator

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[Book] 酸化ストレス認識分子基盤と創薬応用」生命科学から創薬へのイノベーション2014

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[Journal Article] Improving lipophilicity of 5-(1-acetyl-5-phenylpyrazolidin-3-ylidene)-1,3-dimethylbarbituric acid increases its efficacy to activate hypoxia-inducible factors2022

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[Journal Article] Prolyl Hydroxylase Domain Protein Inhibitor Not Harboring a 2-Oxoglutarate Scaffold Protects against Hypoxic Stress2022

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[Journal Article] Anti-Fibrotic and Anti-Angiogenic Activities of Osbeckia octandra Leaf Extracts in Thioacetamide-Induced Experimental Liver Cirrhosis2021

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[Journal Article] Furan- and Thiophene-2-Carbonyl Amino Acid Derivatives Activate Hypoxia-Inducible Factor via Inhibition of Factor Inhibiting Hypoxia-Inducible Factor-12018

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[Journal Article] O-GlcNAcylation Signal Mediates Proteasome Inhibitor Resistance in Cancer Cells by Stabilizing NRF12018

TSUJITA TADAYUKI 辻田忠志

Tsujita Tadayuki 辻田忠志

TSUJITA Tadayuki 辻田忠志