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ARAI DAISUKE  新井 大祐

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Arai Daisuke  新井 大祐

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Researcher Number 20624951
Other IDs
Affiliation (Current) 2025: 順天堂大学, 医学部, 助教
Affiliation (based on the past Project Information) *help 2023: 早稲田大学, 理工学術院, 講師(任期付)
2022 – 2023: 順天堂大学, 医学部, 助教
2018 – 2021: 早稲田大学, 理工学術院, 講師(任期付)
2016 – 2017: 早稲田大学, 理工学術院, 次席研究員(研究院講師)
2015: 早稲田大学, 理工学術院, 講師
2013 – 2014: 早稲田大学, 理工学術院, 助手
Review Section/Research Field
Principal Investigator
Integrative animal science / Basic Section 56050:Otorhinolaryngology-related / Basic Section 42030:Animal life science-related
Except Principal Investigator
Basic Section 56050:Otorhinolaryngology-related / Basic Section 37020:Chemistry and chemical methodology of biomolecules-related / Medium-sized Section 43:Biology at molecular to cellular levels, and related fields / Integrative animal science
Keywords
Principal Investigator
ヒストン修飾 / エピジェネティクス / 細胞分化 / Nodal / 遺伝子発現制御 / ES細胞 / エピゲノム / 難聴 / 蝸牛支持細胞 / ノックイン … More / エピゲノム編集 / 発現制御 / 胚性幹細胞 / クロマチン / DNAメチル化 / ノンコーディングRNA / がん … More
Except Principal Investigator
ChIP-seq / RNA-seq / オミクス解析 / Brn4 / 蝸牛 / 遺伝性難聴 / 作用メカニズム / 天然小分子 / 天然化合物 / 作用メカニズム解明 / 細胞分化 / 質量分析 / タンパク質分解 / ユビキチン / プロテアソーム / ゲノムワイド / グリコシル化 / ゲノムダメージ / Nアセチルグルコサミン(GlcNAc) / 進化 / 胚性幹細胞 / 栄養膜幹細胞 / グルコース感受性 / ゲノム修復 / H2A-アセチルグルコサミン(GlcNAc)修飾 / ヒストン修飾 / エピジェネティクス Less
  • Research Projects

    (8 results)
  • Research Products

    (32 results)
  • Co-Researchers

    (11 People)
  •  オミクス解析によるDFN3難聴の原因遺伝子Brn4の転写制御ターゲットの解明

    • Principal Investigator
      城所 淑信
    • Project Period (FY)
      2023 – 2027
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 56050:Otorhinolaryngology-related
    • Research Institution
      Juntendo University
  •  エピゲノム解析による蝸牛支持細胞の遺伝子発現制御機構の全体像の解明Principal Investigator

    • Principal Investigator
      新井 大祐
    • Project Period (FY)
      2023 – 2025
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 56050:Otorhinolaryngology-related
    • Research Institution
      Juntendo University
  •  Integrated platform for analyzing the modes of actions of natural products

    • Principal Investigator
      Nakao Yoichi
    • Project Period (FY)
      2021 – 2023
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Review Section
      Basic Section 37020:Chemistry and chemical methodology of biomolecules-related
    • Research Institution
      Waseda University
  •  In situ epigenetics: a new strategy for studying H3K27me3 in cellular differentiation and developmentPrincipal Investigator

    • Principal Investigator
      Arai Daisuke
    • Project Period (FY)
      2020 – 2023
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 42030:Animal life science-related
    • Research Institution
      Juntendo University
      Waseda University
  •  Elucidation of protein networks controlling proteasomal degradation

    • Principal Investigator
      SAEKI Yasushi
    • Project Period (FY)
      2018 – 2021
    • Research Category
      Grant-in-Aid for Scientific Research (A)
    • Review Section
      Medium-sized Section 43:Biology at molecular to cellular levels, and related fields
    • Research Institution
      Tokyo Metropolitan Institute of Medical Science
  •  Nutrition-dependent regulation of Nodal gene by a novel histone O-GlcNAc modificationPrincipal Investigator

    • Principal Investigator
      Arai Daisuke
    • Project Period (FY)
      2017 – 2019
    • Research Category
      Grant-in-Aid for Young Scientists (B)
    • Research Field
      Integrative animal science
    • Research Institution
      Waseda University
  •  Epigenetics of trophoblast and embryonic stem cells by a novel histone-glycosylation

    • Principal Investigator
      Shiota Kunio
    • Project Period (FY)
      2014 – 2016
    • Research Category
      Grant-in-Aid for Scientific Research (A)
    • Research Field
      Integrative animal science
    • Research Institution
      Waseda University
      The University of Tokyo
  •  Study on epigenetic regulation of Nodal genePrincipal Investigator

    • Principal Investigator
      Arai Daisuke
    • Project Period (FY)
      2013 – 2015
    • Research Category
      Grant-in-Aid for Young Scientists (B)
    • Research Field
      Integrative animal science
    • Research Institution
      Waseda University

All 2023 2022 2021 2020 2019 2018 2017 2016 2015 2013 Other

All Journal Article Presentation Book

  • [Book] 実験医学2022年2月号『BiPoD:正確かつ高効率な両アレルノックイン新手法』2022

    • Author(s)
      新井大祐
    • Total Pages
      6
    • Publisher
      羊土社
    • ISBN
      9784758125529
    • Data Source
      KAKENHI-PROJECT-20K06449
  • [Journal Article] Generation and characterization of a human iPSC line (JUFMDOi007-A) from a patient with Usher syndrome due to mutation in USH2A2023

    • Author(s)
      Ukaji Takao、Takahashi-Shibata Mikako、Arai Daisuke、Tsutsumi Harumi、Tajima Shori、Akamatsu Wado、Matsumoto Fumihiko、Ikeda Katsuhisa、Usami Shin-ichi、Kamiya Kazusaku
    • Journal Title

      Stem Cell Research

      Volume: 69 Pages: 103100-103100

    • DOI

      10.1016/j.scr.2023.103100

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-23K08997, KAKENHI-PROJECT-20K06449, KAKENHI-PROJECT-21H02814, KAKENHI-PROJECT-21H03089
  • [Journal Article] Coronarin D, a metabolite from the wild turmeric, Curcuma aromatica, promotes the differentiation of neural stem cells into astrocytes.2022

    • Author(s)
      Otsuka, S.; Kawamura, M.; Fujino, S.; Nakamura, F.; Arai, D.; Fusetani, N.; Nakao, Y.
    • Journal Title

      J. Agr. Food Chem.

      Volume: 70 Issue: 10 Pages: 3300-3309

    • DOI

      10.1021/acs.jafc.2c00020

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-21H02073, KAKENHI-PROJECT-20K06449
  • [Journal Article] クローズアップ実験法 BiPoD:正確かつ高効率な両アレルノックイン新手法2022

    • Author(s)
      新井大祐,中尾洋一
    • Journal Title

      実験医学

      Volume: 40 Pages: 459-464

    • Data Source
      KAKENHI-PROJECT-21H02073
  • [Journal Article] Efficient biallelic knock-in in mouse embryonic stem cells by in vivo-linearization of donor and transient inhibition of DNA polymerase θ/DNA-PK.2021

    • Author(s)
      Arai, D.; Nakao, Y.
    • Journal Title

      Sci. Rep.

      Volume: 11 Issue: 1 Pages: 18132-18132

    • DOI

      10.1038/s41598-021-97579-8

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-21H02073, KAKENHI-PROJECT-20K06449
  • [Journal Article] Stress- and ubiquitylation-dependent phase separation of the proteasome2020

    • Author(s)
      Yasuda Sayaka、Tsuchiya Hikaru、Kaiho Ai、Guo Qiang、Ikeuchi Ken、Endo Akinori、Arai Naoko、Ohtake Fumiaki、Murata Shigeo、Inada Toshifumi、Baumeister Wolfgang、Fernandez-Busnadiego Ruben、Tanaka Keiji、Saeki Yasushi
    • Journal Title

      Nature

      Volume: 578 Issue: 7794 Pages: 296-300

    • DOI

      10.1038/s41586-020-1982-9

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-ORGANIZER-18H05497, KAKENHI-PLANNED-18H05498, KAKENHI-PLANNED-18H05500, KAKENHI-PUBLICLY-19H05281, KAKENHI-PROJECT-18H03993, KAKENHI-PROJECT-18H04022, KAKENHI-PROJECT-18K14913, KAKENHI-PROJECT-26000014, KAKENHI-PROJECT-17H03986, KAKENHI-PROJECT-19H00997
  • [Journal Article] Stepwise multipolyubiquitination of p53 by the E6AP-E6 ubiquitin ligase complex2019

    • Author(s)
      Masuda Y, Saeki Y, Arai N, Kawai H, Kukimoto I, Tanaka K, Masutani C.
    • Journal Title

      J Biol Chem

      Volume: 294 Issue: 41 Pages: 14860-14875

    • DOI

      10.1074/jbc.ra119.008374

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-17K11309, KAKENHI-PLANNED-18H05498, KAKENHI-PROJECT-16H01775, KAKENHI-PROJECT-17H00785, KAKENHI-PROJECT-18H03993, KAKENHI-PROJECT-18H03371, KAKENHI-PROJECT-20K20310
  • [Journal Article] HERC2 facilitates BLM and WRN helicase complex interaction with RPA to suppress G-quadruplex DNA.2018

    • Author(s)
      Wu W, Rokutanda N, Takeuchi J, Lai Y, Maruyama R, Togashi Y, Nishikawa H, Arai N, Miyoshi Y,Suzuki N, Saeki Y, Tanaka K, Ohta T.
    • Journal Title

      Cancer Res.

      Volume: 78 Issue: 22 Pages: 6371-6385

    • DOI

      10.1158/0008-5472.can-18-1877

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-17K08676, KAKENHI-ORGANIZER-18H05497, KAKENHI-PLANNED-18H05498, KAKENHI-PROJECT-18H03993, KAKENHI-PROJECT-17H03585, KAKENHI-PROJECT-17K18336
  • [Journal Article] Kakeromamide A, a new cyclic pentapeptide inducing astrocyte differentiation isolated from the marine cyanobacterium2018

    • Author(s)
      Nakamura F, Maejima H, Kawamura M, Arai D, Okino T, Zhao M, Ye T, Lee J, Chang Y-T, Fusetan N, Nakao Y
    • Journal Title

      Bioorg.Med.Chem.Lett.

      Volume: - Issue: 12 Pages: 2206-2209

    • DOI

      10.1016/j.bmcl.2018.04.067

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-26221204, KAKENHI-PROJECT-17K15391, KAKENHI-PROJECT-18H03993, KAKENHI-PROJECT-16H04975, KAKENHI-PROJECT-18H02100
  • [Journal Article] Sameuramide A, a new cyclic depsipeptide isolated from an ascidian of the family Didemnidae.2018

    • Author(s)
      Machida K, Arai D, Katsumata R, Otsuka S, Yamashita JK, Ye T, Tang S, Fusetani N, Nakao Y
    • Journal Title

      Bioorg. Med. Chem.

      Volume: 26 Issue: 13 Pages: 3852-3857

    • DOI

      10.1016/j.bmc.2018.06.042

    • Peer Reviewed / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-17K15391, KAKENHI-PROJECT-18H03993, KAKENHI-PROJECT-26221204, KAKENHI-PROJECT-18H02100
  • [Journal Article] A quantitative shRNA screen identifies ATP1A1 as a gene that regulates cytotoxicity by aurilide B2017

    • Author(s)
      Takase Shohei、Kurokawa Rumi、Arai Daisuke、Kanemoto Kanto Kind、Okino Tatsufumi、Nakao Yoichi、Kushiro Tetsuo、Yoshida Minoru、Matsumoto Ken
    • Journal Title

      Scientific Reports

      Volume: 7 Issue: 1 Pages: 1-9

    • DOI

      10.1038/s41598-017-02016-4

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-17K15391, KAKENHI-PROJECT-26221204
  • [Journal Article] Halistanol sulfates I and J, new SIRT1?3 inhibitory steroid sulfates from a marine sponge of the genus Halichondria2017

    • Author(s)
      Nakamura Fumiaki、Kudo Norio、Tomachi Yuki、Nakata Akiko、Takemoto Misao、Ito Akihiro、Tabei Hodaka、Arai Daisuke、de Voogd Nicole、Yoshida Minoru、Nakao Yoichi、Fusetani Nobuhiro
    • Journal Title

      The Journal of Antibiotics

      Volume: 71 Issue: 2 Pages: 273-278

    • DOI

      10.1038/ja.2017.145

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-17K15391, KAKENHI-PROJECT-26221204, KAKENHI-PLANNED-18H05503
  • [Journal Article] Novel O-GlcNAcylation on Ser40 of canonical H2A isoforms specific to viviparity.2016

    • Author(s)
      Hirosawa M, Hayakawa K, Yoneda C, Arai D, Shiota H, Suzuki T, Tanaka S, Dohmae N, Shiota K.
    • Journal Title

      Scientific Reports

      Volume: 6 Issue: 1

    • DOI

      10.1038/srep31785

    • Peer Reviewed / Acknowledgement Compliant / Open Access
    • Data Source
      KAKENHI-PROJECT-26252052, KAKENHI-PROJECT-26850230, KAKENHI-PROJECT-15K07836
  • [Journal Article] An epigenetic regulatory element of the Nodal gene in the mouse and human genomes.2015

    • Author(s)
      Arai D, Hayakawa K, Ohgane J, Hirosawa M, Nakao Y, Tanaka S, Shiota K.
    • Journal Title

      Mech Dev.

      Volume: 136 Pages: 143-154

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-26252052
  • [Journal Article] An epigenetic regulatory element of the Nodal gene in the mouse and human genomes2015

    • Author(s)
      Daisuke Arai, Koji Hayakawa, Jun Ohgane, Mitsuko Hirosawa, Yoichi Nakao, Satoshi Tanaka, Kunio Shiota
    • Journal Title

      Mechanisms of Development

      Volume: 136 Pages: 143-154

    • DOI

      10.1016/j.mod.2014.12.003

    • Peer Reviewed / Acknowledgement Compliant
    • Data Source
      KAKENHI-PROJECT-25850219, KAKENHI-PROJECT-26850230, KAKENHI-PROJECT-15K07836, KAKENHI-PROJECT-25450472, KAKENHI-PROJECT-25303008, KAKENHI-PROJECT-15H01749
  • [Journal Article] Putative Epimutagens in Maternal Peripheral and Cord Blood Samples Identified Using Human Induced Pluripotent Stem Cells.2015

    • Author(s)
      Arai Y, Hayakawa K, Arai D, Ito R, Iwasaki Y, Saito K, Akutsu K, Takatori S, Ishii R, Hayashi R, Izumi S, Sugino N, Kondo F, Horie M, Nakazawa H, Makino T, Hirosawa M, Shiota K, Ohgane J.
    • Journal Title

      Biomed Res Int.

      Volume: 2015 Pages: 1-13

    • DOI

      10.1155/2015/876047

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-15K07836, KAKENHI-PROJECT-25450472, KAKENHI-PROJECT-15H01749, KAKENHI-PROJECT-26252052
  • [Presentation] ES細胞を用いたGJB2遺伝子変異型難聴in vitroモデルの開発2023

    • Author(s)
      新井大祐, 神谷和作
    • Organizer
      第33回日本耳科学会総会・学術講演会
    • Data Source
      KAKENHI-PROJECT-23K08997
  • [Presentation] マウスES細胞を用いたGJB2遺伝子変異型難聴の新たなin vitro疾患モデル2023

    • Author(s)
      新井大祐, 神谷和作
    • Organizer
      第46回日本分子生物学会年会
    • Data Source
      KAKENHI-PROJECT-23K08997
  • [Presentation] マウスES細胞を用いたGJB2遺伝子変異型難聴の新たなin vitro疾患モデル2023

    • Author(s)
      新井大祐, 神谷和作
    • Organizer
      第68回日本聴覚医学会総会・学術講演会
    • Data Source
      KAKENHI-PROJECT-23K08997
  • [Presentation] 海洋環状ペプチド kapakahine 類のプローブ化および作用機序の解析2022

    • Author(s)
      神平梨絵、新井大祐、中尾洋一
    • Organizer
      第34回 海洋生物活性談話会
    • Data Source
      KAKENHI-PROJECT-21H02073
  • [Presentation] Food Ingredients Controlling Cell Differentiation and Histone Modifications2022

    • Author(s)
      Nakao, Y.; Otsuka, S.; Kawamura, M.; Fujino, S.; Nakamura, F.; Arai, D.; Fusetani, N.
    • Organizer
      22nd IUNS-ICN INTERNATIONAL CONGRESS OF NUTRITION IN TOKYO
    • Invited / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-21H02073
  • [Presentation] 海洋環状ペプチド kapakahine 類のプローブ化および作用機序の解析2022

    • Author(s)
      神平梨絵、新井大祐、中尾洋一
    • Organizer
      第64回 天然有機化合物討論会
    • Data Source
      KAKENHI-PROJECT-21H02073
  • [Presentation] マウスES細胞に対する高効率な両アリルノックイン手法の開発2021

    • Author(s)
      新井大祐,中尾洋一
    • Organizer
      第44回日本分子生物学会年会
    • Data Source
      KAKENHI-PROJECT-21H02073
  • [Presentation] マウスES細胞に対する高効率な両アリルノックイン手法の開発2021

    • Author(s)
      新井大祐, 中尾洋一
    • Organizer
      第44回日本分子生物学会年会
    • Data Source
      KAKENHI-PROJECT-20K06449
  • [Presentation] Improvement of homology-directed repair-mediated knock-in efficiency in mouse embryonic stem cells by using small compounds2021

    • Author(s)
      Arai, D.; Nakao, Y.
    • Organizer
      2021環太平洋国際化学会議(PACIFICHEM2021)
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-21H02073
  • [Presentation] Improvement of homology-directed repair-mediated knock-in efficiency in mouse embryonic stem cells by using small compounds2021

    • Author(s)
      新井大祐, 中尾洋一
    • Organizer
      2021 International Chemical Congress of Pacific Basin Societies
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-20K06449
  • [Presentation] Marine Natural Products that Control a Specific Set of Histone Modifications2019

    • Author(s)
      Daisuke Arai
    • Organizer
      XVI MaNaPro & XI ECMNP, 2019
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-17K15391
  • [Presentation] ヒストンH2AのL1領域におけるアイソフォーム特異的な新規O-GlcNAc修飾2016

    • Author(s)
      廣澤瑞子・早川晃司・米田智佳子・新井大祐・塩田仁志・鈴木健裕・田中智・堂前直・塩田邦郎
    • Organizer
      第39回日本分子生物学会年会
    • Place of Presentation
      パシフィコ横浜(神奈川)
    • Year and Date
      2016-11-30
    • Data Source
      KAKENHI-PROJECT-26252052
  • [Presentation] Marine natural products that control a specific set of histone modifications2015

    • Author(s)
      Daisuke Arai, Chiaki Sakuma, Kind K. Kanto, Yoko Hayashi-Takanaka, Hiroshi Kimura, Yoichi Nakao
    • Organizer
      第40回内藤コンファレンス
    • Place of Presentation
      シャトレーゼ ガトーキングダム サッポロ
    • Year and Date
      2015-09-15
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-25850219
  • [Presentation] Marine natural products that control a specific set of histone modifications2015

    • Author(s)
      Daisuke Arai, Chiaki Sakuma, Yoko Hayashi-Takanaka, Hiroshi Kimura, Yoichi Nakao
    • Organizer
      The 2015 International Chemical Congress of Pacific Basin Societies
    • Place of Presentation
      ハワイコンベンションセンター及びホノルル市内ホテル7会場
    • Year and Date
      2015-12-15
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-25850219
  • [Presentation] エピジェネティック制御下にある新たなNodal遺伝子の制御領域2013

    • Author(s)
      新井大祐、大鐘潤、田中智、塩田邦郎
    • Organizer
      第7回日本エピジェネティクス研究会年会
    • Place of Presentation
      奈良県新公会堂
    • Data Source
      KAKENHI-PROJECT-25850219
  • [Presentation] Nodal遺伝子のエピジェネティック制御

    • Author(s)
      新井大祐、早川晃司、大鐘潤、中尾洋一、田中智、塩田邦郎
    • Organizer
      第8回日本エピジェネティクス研究会年会
    • Place of Presentation
      東京大学 伊藤国際学術研究センター
    • Year and Date
      2014-05-25 – 2014-05-27
    • Data Source
      KAKENHI-PROJECT-25850219
  • 1.  Shiota Kunio (80196352)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 3 results
  • 2.  SAEKI Yasushi (80462779)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 1 results
  • 3.  Nakao Yoichi (60282696)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 9 results
  • 4.  廣澤 瑞子 (60533982)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 4 results
  • 5.  早川 晃司 (50636800)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 3 results
  • 6.  町田 光史 (30778163)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 7.  松本 健 (60222311)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 8.  城所 淑信 (60514487)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 9.  WU Wenwen
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 10.  柊元 巌
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 11.  村田 茂穂
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results

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