KARIYA Yoshiaki 苅谷嘉顕

Researcher Number	20633168
Affiliation (Current)	2025: 東京大学, 大学院薬学系研究科(薬学部), 講師
Affiliation (based on the past Project Information) *help	2023 – 2024: 東京大学, 大学院薬学系研究科(薬学部), 講師 2022: 東京大学, 医学部附属病院, 薬剤主任 2012 – 2021: 東京大学, 医学部附属病院, 助教
Review Section/Research Field	Principal Investigator Orthopaedic surgery / Basic Section 56020:Orthopedics-related / Applied pharmacology Except Principal Investigator Basic Section 47060:Clinical pharmacy-related / Basic Section 47040:Pharmacology-related / Medium-sized Section 90:Biomedical engineering and related fields
Keywords	Principal Investigator 骨代謝 / 破骨細胞 / 骨芽細胞 / 骨リモデリング / RANKL / 骨細胞 / 膜小胞 / 生活動作 / 小胞 / 骨・軟骨代謝学 … More / 骨・軟骨代謝 / exosome / 細胞外膜小胞 / 骨形成 / 細胞遊走 / エクソソーム / カップリング / 医薬品副作用 / 毒性予測法 / 分子標的薬 / 毒性予測 / システム薬理学 / 骨粗鬆症 / 破骨細胞活性化 … More Except Principal Investigator 神経変性疾患 / 脳内移行 / パーキンソン病 / プリン代謝 / 神経変性 / 尿酸 / システム安定性 / 低分子動態 / 炎症 / 自己免疫疾患 / RANKL逆シグナル / シグナル伝達 / 投与量設計 / 治療最適化 / in silico解析 / キナーゼ阻害剤 / 副作用 / 分子標的薬 / がん / 抗がん剤 / システム薬理学 / 機械学習 / 細胞毒性 Less

Understanding of brain purine metabolism for disease modification
- Principal Investigator
  
  鈴木洋史
- Project Period (FY)
  2023 – 2026
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 47060:Clinical pharmacy-related
- Research Institution
  The University of Tokyo
Analysis of the roles of RANKL reverse signaling in the autoimmune disease development
- Principal Investigator
  
  本間雅
- Project Period (FY)
  2022 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 47040:Pharmacology-related
- Research Institution
  The University of Tokyo
Functional analysis of osteocytic membrane vesicles in osteoclast activation under daily activitiesPrincipal Investigator
- Principal Investigator
  
  苅谷嘉顕
- Project Period (FY)
  2021 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 56020:Orthopedics-related
- Research Institution
  The University of Tokyo
Optimization for usage of molecular targeted drugs on cancer therapy
- Principal Investigator
  
  Suzuki Hiroshi
- Project Period (FY)
  2018 – 2021
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Review Section
  
  Medium-sized Section 90:Biomedical engineering and related fields
- Research Institution
  The University of Tokyo
Coupling regulation by osteoclastic exosomesPrincipal Investigator
- Principal Investigator
  
  Kariya Yoshiaki
- Project Period (FY)
  2016 – 2019
- Research Category
  
  Grant-in-Aid for Young Scientists (A)
- Research Field
  
  Orthopaedic surgery
- Research Institution
  The University of Tokyo
Mechanistic analysis for anti-RANKL antibody drug associated severe adverse reactionsPrincipal Investigator
- Principal Investigator
  
  Kariya Yoshiaki
- Project Period (FY)
  2014 – 2015
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Applied pharmacology
- Research Institution
  The University of Tokyo
Subcellular behavior of RANKL in osteocytesPrincipal Investigator
- Principal Investigator
  
  KARIYA Yoshiaki
- Project Period (FY)
  2012 – 2013
- Research Category
  
  Grant-in-Aid for Research Activity Start-up
- Research Field
  
  Orthopaedic surgery
- Research Institution
  The University of Tokyo

All 2019 2018 2016 2015 2014 2013 Other

All Journal Article Presentation Book

[Book] Systems Pharmacology and Pharmacodynamics Chapter 16, Systems Pharmacology of Tyrosine Kinase Inhibitor-Associated Toxicities2016
- Author(s)
  Hiroshi Suzuki, Yoshiaki Kariya, Masashi Honma
- Publisher
  Springer
- Data Source
  KAKENHI-PROJECT-26670265
[Journal Article] Integrative and theoretical research on the architecture of a biological system and its disorder2019
- Author(s)
  Shinichi Uchida, Yoshiyuki Asai, Yoshiaki Kariya, Kunichika Tsumoto, Hiroshi Hibino, Masashi Honma, Takeshi Abe, Fumiaki Nin, Yasutaka Kurata, Kazuharu Furutani, Hiroshi Suzuki, Hiroaki Kitano, Ryuji Inoue, Yoshihisa Kurachi
- Journal Title
  
  The Journal of Physiological Sciences
  
  Volume: 69 Issue: 3 Pages: 443-451
- DOI
  10.1007/s12576-019-00667-8
- NAID
  40021874158
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18H04162, KAKENHI-PROJECT-16KT0194, KAKENHI-PROJECT-18H04062, KAKENHI-PROJECT-17H04018, KAKENHI-PROJECT-15H04678, KAKENHI-PROJECT-16K00410
[Journal Article] Coupling of bone resorption and formation by RANKL reverse signalling.2018
- Author(s)
  Ikebuchi Y, Aoki S, Honma M, Hayashi M, Sugamori Y, Khan M, Kariya Y, Kato G, Tabata Y, Penninger JM, Udagawa N, Aoki K, Suzuki H
- Journal Title
  
  Nature
  
  Volume: 561 Issue: 7722 Pages: 195-200
- DOI
  10.1038/s41586-018-0482-7
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K19776, KAKENHI-PROJECT-16H05445, KAKENHI-PROJECT-16H05508, KAKENHI-PROJECT-18H02918, KAKENHI-PROJECT-16H06261, KAKENHI-PROJECT-17F17124, KAKENHI-PROJECT-16K11818, KAKENHI-PROJECT-16K20419, KAKENHI-PROJECT-18K04734
[Journal Article] Regulatory mechanisms of RANKL presentation to osteoclast precursors2014
- Author(s)
  Masashi Honma, Yuki Ikebuchi, Yoshiaki Kariya, Hiroshi Suzuki
- Journal Title
  
  Current Osteoporosis Reports
  
  Volume: 12(1) Issue: 1 Pages: 115-120
- DOI
  10.1007/s11914-014-0189-0
- Peer Reviewed
- Data Source
  KAKENHI-ORGANIZER-22136001, KAKENHI-PLANNED-22136015, KAKENHI-PROJECT-24390349, KAKENHI-PROJECT-24659668, KAKENHI-PROJECT-24890048, KAKENHI-PROJECT-25670632
[Journal Article] Establishment of optimized in vitro assay methods for evaluating osteocyte functions2014
- Author(s)
  Masashi Honma, Yuki Ikebuchi, Yoshiaki Kariya, Hiroshi Suzuki
- Journal Title
  
  Journal of Bone and Mineral Metabolism
  
  Volume: in press Issue: 1 Pages: 1-12
- DOI
  10.1007/s00774-013-0555-5
- Peer Reviewed
- Data Source
  KAKENHI-ORGANIZER-22136001, KAKENHI-PLANNED-22136015, KAKENHI-PROJECT-24390349, KAKENHI-PROJECT-24890048
[Journal Article] Establishment of optimized in vitro methods for evaluating osteocyte functions2014
- Author(s)
  Honma M, Ikebuchi Y, Kariya Y, Suzuki H
- Journal Title
  
  Journal of bone and mineral metabolism
  
  Volume: (Epub)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24890048
[Journal Article] Regulatory mechanisms of RANKL presentation to osteoclast precursors2014
- Author(s)
  Honma M, Ikebuchi Y, Kariya Y, Suzuki H
- Journal Title
  
  Current osteoporosis reports
  
  Volume: Vol.12 Pages: 115-120
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24890048
[Journal Article] RANKL subcellular trafficking and regulatory mechanisms in osteocytes2013
- Author(s)
  Honma M, Ikebuchi Y, Kariya Y, Hayashi M, Hayashi N, Aoki S, Suzuki H
- Journal Title
  
  Journal of bone and mineral research
  
  Volume: Vol.28 Pages: 1936-1949
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24890048
[Journal Article] Systems-based understanding of pharmacological responses with combinations of multidisciplinary methodologies2013
- Author(s)
  Yoshiaki Kariya, Masashi Honma, Hiroshi Suzuki
- Journal Title
  
  Biopharmaceutics & Drug Disposition
  
  Volume: 28(9) Issue: 9 Pages: 1936-1949
- DOI
  10.1002/jbmr.1941
- Peer Reviewed
- Data Source
  KAKENHI-ORGANIZER-22136001, KAKENHI-PROJECT-24390349, KAKENHI-PROJECT-24890048, KAKENHI-PLANNED-22136015
[Presentation] Prediction method of cardiotoxicity triggered by kinase inhibition2016
- Author(s)
  Yoshiaki Kariya
- Organizer
  第89回日本薬理学会年会
- Place of Presentation
  横浜
- Year and Date
  2016-03-09
- Data Source
  KAKENHI-PROJECT-26670265
[Presentation] 細胞内シグナルネットワークを考慮したシステム薬理学的心毒性予測2015
- Author(s)
  苅谷嘉顕、本間雅、鈴木洋史
- Organizer
  第88回日本薬理学会年会
- Place of Presentation
  名古屋
- Year and Date
  2015-03-19
- Data Source
  KAKENHI-PROJECT-26670265
[Presentation] Prediction of TKI Associated Cardiotoxicity Based on Network Analyses of Intracellular Signaling Pathways2015
- Author(s)
  Yoshiaki Kariya
- Organizer
  Workshop on Pharmacological Mechanism-Based Drug Safety Prediction
- Place of Presentation
  FDA, Silver Spring, MD, US
- Year and Date
  2015-08-06
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26670265
[Presentation] RANKL subcellular trafficking in osteocytes.2013
- Author(s)
  Honma M, Ikebuchi Y, Kariya Y, Hayashi M, Hayashi N, Aoki S, Suzuki H
- Organizer
  European Calcified Tissue Society Congress 2013
- Place of Presentation
  Bone Abstract(1 PP240)
- Data Source
  KAKENHI-PROJECT-24890048
[Presentation] Prediction of cardiac cell apoptosis using systems pharmacological methodologies
- Author(s)
  Yoshiaki Kariya, Masashi Honma, Keita Tokuda, Hiroshi Suzuki
- Organizer
  新学術領域研究「多階層生体機能学」終了記念シンポジウム
- Place of Presentation
  大阪
- Year and Date
  2015-03-04 – 2015-03-06
- Data Source
  KAKENHI-PROJECT-26670265

1. 本間雅 (60401072)

# of Collaborated Projects: 3 results

# of Collaborated Products: 1 results
2. 池淵祐樹 (20645725)

# of Collaborated Projects: 3 results

# of Collaborated Products: 0 results
3. Suzuki Hiroshi (80206523)

# of Collaborated Projects: 2 results

# of Collaborated Products: 4 results
4. 高田龍平 (90376468)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
5. 宇田川信之

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

KARIYA Yoshiaki 苅谷 嘉顕

Research Projects

Research Products

Co-Researchers

Understanding of brain purine metabolism for disease modification

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Analysis of the roles of RANKL reverse signaling in the autoimmune disease development

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Functional analysis of osteocytic membrane vesicles in osteoclast activation under daily activitiesPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Optimization for usage of molecular targeted drugs on cancer therapy

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Coupling regulation by osteoclastic exosomesPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Mechanistic analysis for anti-RANKL antibody drug associated severe adverse reactionsPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Subcellular behavior of RANKL in osteocytesPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Book] Systems Pharmacology and Pharmacodynamics Chapter 16, Systems Pharmacology of Tyrosine Kinase Inhibitor-Associated Toxicities2016

Author(s)

Publisher

Data Source

[Journal Article] Integrative and theoretical research on the architecture of a biological system and its disorder2019

Author(s)

Journal Title

DOI

NAID

Data Source

[Journal Article] Coupling of bone resorption and formation by RANKL reverse signalling.2018

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Regulatory mechanisms of RANKL presentation to osteoclast precursors2014

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Establishment of optimized in vitro assay methods for evaluating osteocyte functions2014

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Establishment of optimized in vitro methods for evaluating osteocyte functions2014

Author(s)

Journal Title

Data Source

[Journal Article] Regulatory mechanisms of RANKL presentation to osteoclast precursors2014

Author(s)

Journal Title

Data Source

[Journal Article] RANKL subcellular trafficking and regulatory mechanisms in osteocytes2013

KARIYA Yoshiaki 苅谷嘉顕