Saito Takuro 西塔拓郎

Researcher Number	20646468
Other IDs
Affiliation (Current)	2026: 大阪大学, 大学院医学系研究科, 特任准教授(常勤)
Affiliation (based on the past Project Information) *help	2024 – 2026: 大阪大学, 大学院医学系研究科, 特任准教授(常勤) 2022 – 2023: 大阪大学, 大学院医学系研究科, 助教 2021: 大阪大学, 医学系研究科, 助教 2020: 大阪大学, 医学系研究科, 特任助教(常勤) 2020: 大阪大学, 大学院医学系研究科, 助教
Review Section/Research Field	Principal Investigator Basic Section 55020:Digestive surgery-related / Basic Section 50010:Tumor biology-related Except Principal Investigator Basic Section 55020:Digestive surgery-related / Basic Section 50010:Tumor biology-related / Basic Section 56030:Urology-related / Basic Section 59040:Nutrition science and health science-related / Basic Section 59010:Rehabilitation science-related
Keywords	Principal Investigator 免疫チェックポイント分子 / T細胞疲弊化 / リンパ節 / 胃癌 / Precursor T細胞 / 抗PD1抗体 / 所属リンパ節 / 免疫抑制機構 / 胃癌リンパ節 / PD1 / PD-L1 / PD-1 / エクソソーム … More Except Principal Investigator … More 制御性T細胞 / 胃癌 / 食道癌 / 侵襲反応 / カウンターホルモン / 術後血糖 / 遺伝子変異 / 微小免疫環境 / HP感染 / 血液 / 細菌叢 / Ｄアミノ酸 / CD31 / 血管新生 / Cutibacterium acnes / 癌免疫療法 / 細菌関連代謝物 / Firmicutes / Bacteroidia / 細胞外小胞 / エクソソーム / 効果予測 / 免疫療法 / 腎細胞癌 / 尿路上皮癌 / 血液内細菌叢 / CCL1 / CCR8 / 腫瘍免疫環境 / ISH法 / CCR8発現細胞 / CCL1発現細胞 / CCR8陽性Treg / 術前除菌 / ICOS / H. pylori / ICOS+ Treg / 除菌 / H.pylori / 樹状細胞 / H.pylori除菌 / ICOS陽性Treg / H. pylori除菌 / 2型糖尿病 / 腸内細菌叢 / 減量効果・糖尿病改善効果 / 腹腔鏡下スリーブ状胃切除術 / 腹腔鏡下スリーブ状胃切除 / 腸内細菌 / 糖尿病 / スリーブ状胃切除 / 減量・代謝改善手術 / 栄養療法 / 術前リハビリテーション / 筋肉量 / アプリ / リハビリテーション / 術前リハ栄養 / 栄養 / リハビリ / サルコペニア / 癌治療 / 高齢者 / 術前化学療法 / 運動栄養介入 / 運動・栄養介入 / フレイル / 高齢癌患者 Less

腫瘍免疫を活かすピロリ菌除菌による新たな胃癌治療戦略Principal Investigator
- Principal Investigator
  
  西塔拓郎
- Project Period (FY)
  2026 – 2028
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 50010:Tumor biology-related
- Research Institution
  The University of Osaka
ピロリ菌除菌後胃癌における遺伝子異常と抗腫瘍免疫応答の解明
- Principal Investigator
  
  中本蓮之助
- Project Period (FY)
  2025 – 2027
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 50010:Tumor biology-related
- Research Institution
  The University of Osaka
食道癌における治療反応性高血糖が予後に与える影響とそのメカニズム解析
- Principal Investigator
  
  山下公太郎
- Project Period (FY)
  2025 – 2027
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 55020:Digestive surgery-related
- Research Institution
  The University of Osaka
Elucidation of the cancer local immune status constructed by the systemic circulating microbiome and bacterial-related metabolism in urogenital cancer
- Principal Investigator
  
  Kawashima Atsunari
- Project Period (FY)
  2024
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 56030:Urology-related
- Research Institution
  Osaka University
CCL1-CCR8経路を介した腫瘍内Treg制御による治療法の探索
- Principal Investigator
  
  中井慈人
- Project Period (FY)
  2023 – 2025
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 50010:Tumor biology-related
- Research Institution
  Osaka University
ニボルマブ結合T細胞検出法を用いた免疫チェックポイント阻害薬の治療効果機序の解明Principal Investigator
- Principal Investigator
  
  西塔拓郎
- Project Period (FY)
  2023 – 2025
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 55020:Digestive surgery-related
- Research Institution
  Osaka University
The impact of pre-operative eradication therapy of H. pylori on the prognosis of gastric cancer patients and ICOS+ Treg
- Principal Investigator
  
  Shinya Urakawa
- Project Period (FY)
  2022 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 55020:Digestive surgery-related
- Research Institution
  Osaka University
Development of preoperative rehabilitation and nutritional support program for improving treatment outcome of elderly gastric cancer patients
- Principal Investigator
  
  Yamamoto Kazuyoshi
- Project Period (FY)
  2021 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 59010:Rehabilitation science-related
- Research Institution
  Osaka University
Elucidation of the relationship between the intestinal flora (especially Akkermansia muciniphila) and the effects of weight loss and diabetes improvement after bariatric and metabolic surgery
- Principal Investigator
  
  Yamaguchi Tsuyoshi
- Project Period (FY)
  2021 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 59040:Nutrition science and health science-related
- Research Institution
  Shiga University of Medical Science
A trial of exercise and nutrition treatment for aged esophageal cancer patients undergoing neoadjuvant chemotherapy
- Principal Investigator
  
  YAMASAKI Makoto
- Project Period (FY)
  2020 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 55020:Digestive surgery-related
- Research Institution
  Kansai Medical University
  Osaka University
The analysis for the suppressive mechanism of antitumor immunity in lymph nods of gastric cancerPrincipal Investigator
- Principal Investigator
  
  Saito Takuro
- Project Period (FY)
  2020 – 2021
- Research Category
  
  Grant-in-Aid for Early-Career Scientists
- Review Section
  
  Basic Section 55020:Digestive surgery-related
- Research Institution
  Osaka University

All 2024 2023 2022 2021

All Journal Article Presentation

[Journal Article] In situ analysis of CCR8+ regulatory T cells in lung cancer: suppression of GzmB+ CD8+ T cells and prognostic marker implications2024
- Author(s)
  Hayashi Yoshinori、Ueyama Azumi、Funaki Soichiro、Jinushi Koichi、Higuchi Naoko、Morihara Hitomi、Hirata Michinari、Nagira Yoji、Saito Takuro、Kawashima Atsunari、Iwahori Kota、Shintani Yasushi、Wada Hisashi
- Journal Title
  
  BMC Cancer
  
  Volume: 24 Issue: 1 Pages: 627-627
- DOI
  10.1186/s12885-024-12363-x
- Data Source
  KAKENHI-PROJECT-23K08194
[Journal Article] Cutibacterium acnes‐derived extracellular vesicles promote tumor growth in renal cell carcinoma2024
- Author(s)
  Jingushi Kentaro、Kawashima Atsunari、Tanikawa Sayaka、Saito Takuro、Yamamoto Akinaru、Uemura Toshihiro、Sassi Nesrine、Ishizuya Yu、Yamamoto Yoshiyuki、Kato Taigo、Hatano Koji、Hase Hiroaki、Nonomura Norio、Tsujikawa Kazutake
- Journal Title
  
  Cancer Science
  
  Volume: 1 Issue: 8 Pages: 1-1
- DOI
  10.1111/cas.16202
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-23K24472
[Journal Article] Bacterial information in serum extracellular vesicles reflects the inflammation of adherent perinephric fat2024
- Author(s)
  Uemura Toshihiro,Kawashima Atsunari,Jingushi Kentaro,Motooka Daisuke,Saito Takuro,Sassi Nesrine,Horibe Yuki,Yamamoto Akinaru,Liu Yutong,Tani Masaru,Yoshimura Akihiro,Oka Toshiki,Okuda Yohei,Yamamichi Gaku,Ishizuya Yu,Yamamoto Yoshiyuki,Kato Taigo,Hatano Koji,Tsujikawa Kazutake,Wada Hisashi,Nonomura Norio
- Journal Title
  
  Cancer Science
  
  Volume: 116 Issue: 2 Pages: 338-349
- DOI
  10.1111/cas.16410
- Data Source
  KAKENHI-PROJECT-23K24472, KAKENHI-PROJECT-22K09469, KAKENHI-PROJECT-23K08194
[Journal Article] CD45RO-Positive Memory T-Cell Density in the Tumoral Core and Invasive Margin Predict Long-Term Survival in Esophageal Squamous Cell Carcinoma2024
- Author(s)
  Noma Toshiki、Makino Tomoki、Ohshima Kenji、Yamashita Kotaro、Saito Takuro、Tanaka Koji、Yamamoto Kazuyoshi、Takahashi Tsuyoshi、Kurokawa Yukinori、Nakajima Kiyokazu、Morii Eiichi、Eguchi Hidetoshi、Doki Yuichiro
- Journal Title
  
  Annals of Surgical Oncology
  
  Volume: 32 Issue: 3 Pages: 1953-1962
- DOI
  10.1245/s10434-024-16530-z
- Data Source
  KAKENHI-PROJECT-23K08194
[Journal Article] Serum NY-ESO-1 antibody as a predictive biomarker for postoperative recurrence of gastric cancer: a multicenter prospective observational study2024
- Author(s)
  Saito Takuro、Kurokawa Yukinori、Fujitani Kazumasa、Kawabata Ryohei、Takeno Atsushi、Mikami Jota、Endo Shunji、Matsuyama Jin、Akamaru Yusuke、Hirota Masashi、Kishi Kentaro、Urakawa Shinya、Yamamoto Kei、Tanaka Koji、Takahashi Tsuyoshi、Oka Mikio、Wada Hisashi、Eguchi Hidetoshi、Doki Yuichiro
- Journal Title
  
  British Journal of Cancer
  
  Volume: 130 Issue: 7 Pages: 1157-1165
- DOI
  10.1038/s41416-023-02540-3
- Data Source
  KAKENHI-PROJECT-23K08194
[Journal Article] Integrated analysis of phase 1a and 1b randomized controlled trials; Treg-targeted cancer immunotherapy with the humanized anti-CCR4 antibody, KW-0761, for advanced solid tumors2023
- Author(s)
  Fujikawa Kaoru、Saito Takuro、Kurose Koji、Kojima Takashi、Funakoshi Takeru、Sato Eiichi、Kakimi Kazuhiro、Iida Shinsuke、Doki Yuichiro、Oka Mikio、Ueda Ryuzo、Wada Hisashi
- Journal Title
  
  PLOS ONE
  
  Volume: 18 Issue: 9 Pages: 0291772-0291772
- DOI
  10.1371/journal.pone.0291772
- Data Source
  KAKENHI-PROJECT-23K08194
[Journal Article] C-reactive protein kinetics as a predictive marker for long-term outcome of immune checkpoint inhibitors in oesophagogastric cancer2023
- Author(s)
  Nose Yohei、Saito Takuro、Kurokawa Yukinori、Takahashi Tsuyoshi、Yamamoto Kazuyoshi、Momose Kota、Yamashita Kotaro、Tanaka Koji、Makino Tomoki、Eguchi Hidetoshi、Doki Yuichiro、Wada Hisashi
- Journal Title
  
  BJC Reports
  
  Volume: 1 Issue: 1 Pages: 7-7
- DOI
  10.1038/s44276-023-00005-x
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-23K08194
[Journal Article] Bacteria-derived DNA in serum extracellular vesicles are biomarkers for renal cell carcinoma2023
- Author(s)
  Uemura Toshihiro、Kawashima Atsunari、Jingushi Kentaro、Motooka Daisuke、Saito Takuro、Nesrine Sassi、Oka Toshiki、Okuda Yohei、Yamamoto Akinaru、Yamamichi Gaku、Tomiyama Eisuke、Ishizuya Yu、Yamamoto Yoshiyuki、Kato Taigo、Hatano Koji、Tsujikawa Kazutake、Wada Hisashi、Nonomura Norio
- Journal Title
  
  Heliyon
  
  Volume: 9 Issue: 9 Pages: e19800-e19800
- DOI
  10.1016/j.heliyon.2023.e19800
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-22K09469, KAKENHI-PROJECT-23K24472
[Journal Article] Density and maturity of peritumoral tertiary lymphoid structures in oesophageal squamous cell carcinoma predicts patient survival and response to immune checkpoint inhibitors.2023
- Author(s)
  Hayashi Y, Makino T, Sato E, Ohshima K, Nogi Y, Kanemura T, Honma K, Yamashita K, Saito T, Tanaka K, Yamamoto K, Takahashi T, Kurokawa Y, Miyata H, Nakajima K, Wada H, Morii E, Eguchi H, Doki Y.
- Journal Title
  
  Br J Cancer.
  
  Volume: - Issue: 12 Pages: 2175-2185
- DOI
  10.1038/s41416-023-02235-9
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-21K08776, KAKENHI-PROJECT-22K07278, KAKENHI-PROJECT-23K08194
[Journal Article] Propranolol suppresses gastric cancer cell growth by regulating proliferation and apoptosis2021
- Author(s)
  Koh Masahiro、Takahashi Tsuyoshi、Kurokawa Yukinori、Kobayashi Teruyuki、Saito Takuro、Ishida Tomo、Serada Satoshi、Fujimoto Minoru、Naka Tetsuji、Wada Noriko、Yamashita Kotaro、Tanaka Koji、Miyazaki Yasuhiro、Makino Tomoki、Nakajima Kiyokazu、Yamasaki Makoto、Eguchi Hidetoshi、Doki Yuichiro
- Journal Title
  
  Gastric Cancer
  
  Volume: 24 Issue: 5 Pages: 1037-1049
- DOI
  10.1007/s10120-021-01184-7
- NAID
  40022652391
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K17685
[Journal Article] Taste alteration after gastrectomy in patients with gastric cancer2021
- Author(s)
  Hagi Takaomi、Kurokawa Yukinori、Takahashi Tsuyoshi、Saito Takuro、Yamashita Kotaro、Tanaka Koji、Makino Tomoki、Yamasaki Makoto、Motoori Masaaki、Kimura Yutaka、Nakajima Kiyokazu、Eguchi Hidetoshi、Doki Yuichiro
- Journal Title
  
  Surgery Today
  
  Volume: 51 Issue: 5 Pages: 777-784
- DOI
  10.1007/s00595-020-02194-1
- Data Source
  KAKENHI-PROJECT-20K17685
[Presentation] CRP推移による胃癌免疫チェックポイント阻害薬のアウトカム予測2023
- Author(s)
  西塔拓郎
- Organizer
  第27回日本がん免疫学会
- Data Source
  KAKENHI-PROJECT-23K08194
[Presentation] CRP kinetics as a predictive marker for outcome to immune checkpoint inhibitors in upper gastrointestinal cancer2023
- Author(s)
  西塔拓郎
- Organizer
  第82回日本癌学会
- Data Source
  KAKENHI-PROJECT-23K08194
[Presentation] 術前ピロリ菌除菌が抗腫瘍免疫を介して胃癌の予後に与える影響2022
- Author(s)
  西塔拓郎
- Organizer
  日本外科学会
- Data Source
  KAKENHI-PROJECT-22K08846

1. 黒川幸典 (10470197)

# of Collaborated Projects: 5 results

# of Collaborated Products: 3 results
2. 山下公太郎 (20747159)

# of Collaborated Projects: 3 results

# of Collaborated Products: 0 results
3. 和田尚 (70243459)

# of Collaborated Projects: 3 results

# of Collaborated Products: 5 results
4. 田中晃司 (70621019)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
5. 牧野知紀 (80528620)

# of Collaborated Projects: 2 results

# of Collaborated Products: 1 results
6. 高橋剛 (50452389)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
7. YAMASAKI Makoto (50444518)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
8. Yamamoto Kazuyoshi (70528637)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
9. Yamaguchi Tsuyoshi (10510290)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
10. Shinya Urakawa (40768975)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
11. Kawashima Atsunari (50746568)

# of Collaborated Projects: 1 results

# of Collaborated Products: 3 results
12. 松浦記大 (90804477)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
13. 谷眞至 (60236677)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
14. 大城崇司 (60404563)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
15. 太田正之 (80271104)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
16. 井上健太郎 (90368209)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
17. 井本博文 (20754922)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
18. 加野将之 (20456023)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
19. 中井慈人 (40912027)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
20. 木村友則 (00631300)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
21. 元岡大祐 (10636830)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
22. 野々村祝夫 (30263263)

# of Collaborated Projects: 1 results

# of Collaborated Products: 3 results
23. 神宮司健太郎 (80707571)

# of Collaborated Projects: 1 results

# of Collaborated Products: 3 results
24. 中本蓮之助 (31001430)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
25. 植村俊彦

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
26. 土岐祐一郎

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Saito Takuro 西塔 拓郎

Research Projects

Research Products

Co-Researchers

腫瘍免疫を活かすピロリ菌除菌による新たな胃癌治療戦略Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

ニボルマブ結合T細胞検出法を用いた免疫チェックポイント阻害薬の治療効果機序の解明Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

The analysis for the suppressive mechanism of antitumor immunity in lymph nods of gastric cancerPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

[Journal Article] In situ analysis of CCR8+ regulatory T cells in lung cancer: suppression of GzmB+ CD8+ T cells and prognostic marker implications2024

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Cutibacterium acnes‐derived extracellular vesicles promote tumor growth in renal cell carcinoma2024

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Bacterial information in serum extracellular vesicles reflects the inflammation of adherent perinephric fat2024

Author(s)

Journal Title

DOI

Data Source

[Journal Article] CD45RO-Positive Memory T-Cell Density in the Tumoral Core and Invasive Margin Predict Long-Term Survival in Esophageal Squamous Cell Carcinoma2024

Author(s)

Journal Title

Saito Takuro 西塔拓郎