Higashisaka Kazuma 東阪和馬

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HIGASHISAKA Kazuma 東阪和馬

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Researcher Number	20646757
Other IDs
Affiliation (Current)	2025: 大阪大学, 高等共創研究院, 准教授
Affiliation (based on the past Project Information) *help	2021 – 2025: 大阪大学, 高等共創研究院, 准教授 2022: 大阪大学, 医学系研究科, 特任講師(常勤) 2017 – 2020: 大阪大学, 医学系研究科, 特任講師(常勤) 2016: 大阪大学, 薬学研究科, 助教 2013 – 2014: 大阪大学, 薬学研究科(研究院), 助教
Review Section/Research Field	Principal Investigator Basic Section 63030:Chemical substance influence on environment-related / Medical engineering assessment / Medium-sized Section 63:Environmental analyses and evaluation and related fields / Basic Section 58020:Hygiene and public health-related: including laboratory approach Except Principal Investigator Medium-sized Section 58:Society medicine, nursing, and related fields
Keywords	Principal Investigator ナノマテリアル / 化学物質 / 胎盤毒性 / 免疫毒性 / ナノ粒子 / 精神疾患 / 外因性微粒子 / エピジェネティクス / プロテアソーム / ナノ銀粒子 … More / DNAメチル化 / 血液毒性 / 急性期蛋白質 / 安全性評価マーカー / バイオマーカー … More Except Principal Investigator メタボロミクス / 腸内細菌メタゲノム / ゲノム / 乳幼児突然死 / 自律神経関連遺伝子変異 / 心疾患関連遺伝子変異 / メタゲノム解析 / 動物モデル解析 / 死因診断マーカ / 致死的遺伝子 / 死因究明 / ゲノム変異 / 死因究明学 / エクソーム解析 / オミックス解析 / ゲノム変異解析 / 心肥大 / 副交感神経 / 心疾患関連遺伝子 / 自律神経関連遺伝子 / メタボロミクス解析 / 全エクソーム解析 / 突然死 Less

プラスチック微粒子のリスク解析に向けた胎盤毒性の評価と機序解明Principal Investigator
- Principal Investigator
  
  東阪和馬
- Project Period (FY)
  2025 – 2027
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 63030:Chemical substance influence on environment-related
- Research Institution
  The University of Osaka
Development of placental toxicity evaluation method for chemical substances and investigation of next-generation's healthPrincipal Investigator
- Principal Investigator
  
  東阪和馬
- Project Period (FY)
  2023 – 2025
- Research Category
  
  Grant-in-Aid for Challenging Research (Exploratory)
- Review Section
  
  Medium-sized Section 63:Environmental analyses and evaluation and related fields
- Research Institution
  Osaka University
Immunotoxicity assessment of nanoparticles and development into risk analysisPrincipal Investigator
- Principal Investigator
  
  東阪和馬
- Project Period (FY)
  2022 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 63030:Chemical substance influence on environment-related
- Research Institution
  Osaka University
Effects of nanoparticles on the central nervous system and the onset of depressionPrincipal Investigator
- Principal Investigator
  
  Higashisaka Kazuma
- Project Period (FY)
  2019 – 2021
- Research Category
  
  Grant-in-Aid for Early-Career Scientists
- Review Section
  
  Basic Section 58020:Hygiene and public health-related: including laboratory approach
- Research Institution
  Osaka University
Challenge for prevention of sudden unexplained death : Elucidation of molecular mechanisms of death by transomics analysis
- Principal Investigator
  
  MATSUMOTO HIROSHI
- Project Period (FY)
  2018 – 2020
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Review Section
  
  Medium-sized Section 58:Society medicine, nursing, and related fields
- Research Institution
  Osaka University
Elucidation of the mechanism of nanoparticle-induced biological effects focusing on epigenetic regulationPrincipal Investigator
- Principal Investigator
  
  Higashisaka Kazuma
- Project Period (FY)
  2016 – 2018
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Medical engineering assessment
- Research Institution
  Osaka University
Identification of biomarkers for development of the efficacy and safety of nanomaterialsPrincipal Investigator
- Principal Investigator
  
  HIGASHISAKA Kazuma
- Project Period (FY)
  2013 – 2014
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Medical engineering assessment
- Research Institution
  Osaka University

All 2024 2023 2022 2021 2020 2019 2018 2017 2016 2014 2013 Other

All Journal Article Presentation

[Journal Article] Molecular mechanism of cerebral edema improvement via IL-1RA released from stroke-unaffected hindlimb by treadmill exercise after cerebral infarction in rats2023
- Author(s)
  Gono R, Sugimoto K, Yang C, Murata Y, Nomura R, Shirazaki M, Harada K, Harada T, Miyashita Y, Higashisaka K, Katada R, Matsumoto H
- Journal Title
  
  J Cereb. Blood Flow Metab
  
  Volume: 43 Issue: 5 Pages: 812-827
- DOI
  10.1177/0271678x231151569
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21K10521, KAKENHI-PROJECT-18H04078
[Journal Article] Barium-induced toxic anterior segment syndrome2021
- Author(s)
  Matsushita Kenji、Kawashima Rumi、Hashida Noriyasu、Hamano Yuki、Harada Kazuo、Higashisaka Kazuma、Baba Koichi、Sato Shigeru、Huang Weiran、Matsumoto Hiroshi、Hamanaka Teruhiko、Quantock Andrew J.、Nishida Kohji
- Journal Title
  
  European Journal of Ophthalmology
  
  Volume: 1 Issue: 3 Pages: 1-5
- DOI
  10.1177/11206721211069223
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K09406, KAKENHI-PROJECT-20K18379, KAKENHI-PROJECT-21K09741, KAKENHI-PROJECT-18H04078
[Journal Article] Molecular mechanisms of Wischnewski spot development on gastric mucosa in fatal hypothermia: an experimental study in rats2020
- Author(s)
  Chihpin Yang, Kana Sugimoto, Yukie Murata, Yuichiro Hirata, Yu Kamakura, Yoshihisa Koyama, Yohei Miyashita, Kentaro Nakama, Kazuma Higashisaka, Kazuo Harada, Ryuichi Katada, Hiroshi Matsumoto
- Journal Title
  
  Scientific Reports
  
  Volume: 10 Issue: 1 Pages: 1877-1877
- DOI
  10.1038/s41598-020-58894-8
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K09456, KAKENHI-PROJECT-19K24255, KAKENHI-PROJECT-16K10721, KAKENHI-PROJECT-18K10125, KAKENHI-PROJECT-18H04078
[Journal Article] Activated microglia-derived macrophage-like cells exacerbate brain edema after ischemic stroke correlate with astrocytic expression of aquaporin-4 and interleukin-1 alpha release2020
- Author(s)
  Murata Yukie、Sugimoto Kana、Yang Chihpin、Harada Kazuo、Gono Rina、Harada Teiji、Miyashita Yohei、Higashisaka Kazuma、Katada Ryuichi、Tanaka Junya、Matsumoto Hiroshi
- Journal Title
  
  Neurochemistry International
  
  Volume: 140 Pages: 104848-104848
- DOI
  10.1016/j.neuint.2020.104848
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K10125, KAKENHI-PROJECT-19K09456, KAKENHI-PROJECT-20K21465, KAKENHI-PROJECT-18H04078
[Journal Article] Silver Nanoparticles Induce DNA Hypomethylation through Proteasome-Mediated Degradation of DNA Methyltransferase 12020
- Author(s)
  Maki Ayaka、Lin Ying、Aoyama Michihiko、Sato Kenta、Gao Jian-Qing、Tsujino Hirofumi、Nagano Kazuya、Higashisaka Kazuma、Tsutsumi Yasuo
- Journal Title
  
  Biological and Pharmaceutical Bulletin
  
  Volume: 43 Issue: 12 Pages: 1924-1930
- DOI
  10.1248/bpb.b20-00631
- NAID
  130007948708
- ISSN
  0918-6158, 1347-5215
- Year and Date
  2020-12-01
- Language
  English
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K19409
[Journal Article] Optimization and Evaluation of Pretreatment Method for sp-ICP-MS to Reveal the Distribution of Silver Nanoparticles in the Body2019
- Author(s)
  Ishizaka Takuya、Nagano Kazuya、Tasaki Ikkei、Tao Hong、Gao Jian-Qing、Harada Kazuo、Hirata Kazumasa、Saito Shigeru、Tsujino Hirofumi、Higashisaka Kazuma、Tsutsumi Yasuo
- Journal Title
  
  Nanoscale Research Letters
  
  Volume: 14 Issue: 1 Pages: 180-180
- DOI
  10.1186/s11671-019-3016-9
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K19409
[Journal Article] Development and evaluation of a simultaneous and efficient quantification strategy for final prostanoid metabolites in urine2019
- Author(s)
  Tian-qi Zhang, Hirotaka Kuroda, Kazuya Nagano, Soshi Terada, Jian-Qing Gao, Kazuo Harada, Kazumasa Hirata, Hirofumi Tsujino, Kazuma Higashisaka, Hiroshi Matsumoto, Yasuo Tsutsumi
- Journal Title
  
  Prostaglandins, Leukotrienes and Essential Fatty Acids
  
  Volume: 6 Pages: 102032-102032
- DOI
  10.1016/j.plefa.2019.102032
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K19905, KAKENHI-PROJECT-18H04078
[Journal Article] Relationship between size and surface modification of silica particles and enhancement and suppression of inflammatory cytokine production by lipopolysaccharide or peptidoglycan stimulated RAW264.7 macrophages2016
- Author(s)
  Uemura E., Yoshioka Y., Hirai T., Handa T., Nagano K., Higashisaka K., Tsutsumi Y.
- Journal Title
  
  J. Nanopart. Res.
  
  Volume: 18 Issue: 6
- DOI
  10.1007/s11051-016-3475-1
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-16K01437
[Journal Article] Neutrophilia due to silica nanoparticles induces release of double-stranded DNA.2014
- Author(s)
  Higashisaka K., Kunieda A., Iwahara Y., Tanaka K., Nagano K., Mukai Y., Kamada H., Tsunoda S., Yoshioka Y., Tsutsumi Y.
- Journal Title
  
  Journal of Nanomedicine & Nanotechnology.
  
  Volume: 5 Issue: 05 Pages: 1000236-1000236
- DOI
  10.4172/2157-7439.1000236
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-25750194
[Presentation] ヒトと微粒子との環境共生に向けたナノマテリアルの物性とハザード発現との連関解析2024
- Author(s)
  東阪和馬
- Organizer
  日本薬学会第144年会
- Data Source
  KAKENHI-PROJECT-23K25003
[Presentation] 脆弱世代の健康確保に向けた化学物質の胎盤毒性解析2024
- Author(s)
  東阪和馬
- Organizer
  日本薬学会第144年会
- Data Source
  KAKENHI-PROJECT-23K18520
[Presentation] Cell-mediated immunity exacerbates amorphous silica nanoparticles-induced hepatic damage.2023
- Author(s)
  Higashisaka K., Haga Y., Tsutsumi Y.
- Organizer
  American College of Toxicology 2023 Annual Meeting
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-23K25003
[Presentation] Forskolin誘導性のBeWo細胞合胞体化過程に対するバルプロ酸の影響評価2023
- Author(s)
  奥野和香子, 東阪和馬, 小林純大, 謝　燕坤, 村中瑞希, 芳賀優弥, 堤　康央
- Organizer
  第73回日本薬学会関西支部総会・大会
- Data Source
  KAKENHI-PROJECT-23K18520
[Presentation] 香粧品中ナノマテリアルの安全性評価：獲得免疫系を介した非晶質ナノシリカのハザード解析とその発現機序解明2022
- Author(s)
  東阪和馬, 衞藤舜一, 小椋万生, 櫻井美由紀, 辻野博文, 芳賀優弥, 堤　康央
- Organizer
  第47回日本香粧品学会
- Data Source
  KAKENHI-PROJECT-23K25003
[Presentation] ヒトの健康へのリスク解析に資するナノマテリアルの神経細胞分化におよぼす影響とその機序解明2022
- Author(s)
  東阪和馬
- Organizer
  日本薬学会第142年会
- Data Source
  KAKENHI-PROJECT-19K19409
[Presentation] 非晶質ナノシリカの鼻腔を介した吸入曝露が免疫系におよぼす影響の評価2022
- Author(s)
  東阪和馬, 小椋万生, 衞藤舜一, 櫻井美由紀, 辻野博文, 芳賀優弥, 堤　康央
- Organizer
  日本薬剤学会第37年会
- Data Source
  KAKENHI-PROJECT-23K25003
[Presentation] 銀ナノ粒子が神経細胞の分化におよぼす影響評価2021
- Author(s)
  山口慎太郎, 東阪和馬, 井阪　亮, 坂橋優治, 清本琴淑, 北原　剛, 泉谷里奈, 小林純大, 辻野博文, 長野一也, 堤　康央
- Organizer
  日本薬学会第141年会
- Data Source
  KAKENHI-PROJECT-19K19409
[Presentation] 非晶質ナノシリカ曝露によるエンドサイトーシス障害の評価2021
- Author(s)
  櫻井美由紀, 東阪和馬, 衛藤舜一, 越田　葵, 小椋万生, 仲本有里菜, 辻野博文, 長野一也, 堤　康央
- Organizer
  日本薬学会第141年会
- Data Source
  KAKENHI-PROJECT-19K19409
[Presentation] ナノ銀粒子による神経細胞でのアミロイドβ発現増加とその誘導機序の解明に向けた検討2020
- Author(s)
  東阪和馬, 笠原淳平, 櫻井美由紀, 豊田麻人, 衛藤舜一, 辻野博文, 長野一也, 堤　康央
- Organizer
  第47回日本毒性学会
- Data Source
  KAKENHI-PROJECT-19K19409
[Presentation] Analysis of nanoparticles-induced biological effects for ensuring safety.2019
- Author(s)
  Higashisaka K.
- Organizer
  The 2nd World Summit on Toxicology and Applied Pharmacology
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K19409
[Presentation] 非晶質ナノシリカが精巣に及ぼす、エピジェネティックな変異を介したハザード同定2019
- Author(s)
  佐藤建太, 東阪和馬, 衛藤舜一, 越田　葵, 小椋万生, 辻野博文, 長野一也, 堤　康央
- Organizer
  日本薬学会第139年会
- Data Source
  KAKENHI-PROJECT-16K01437
[Presentation] 食品関連製品に含まれるナノ素材の安全性評価～ナノ安全科学研究からナノ最適デザイン研究へ～2018
- Author(s)
  東阪和馬, 長野一也, 松本博志, 堤　康央
- Organizer
  第34回日本毒性病理学会（シンポジウム：ナノ化学物質の安全性評価と展望）
- Data Source
  KAKENHI-PROJECT-16K01437
[Presentation] 銀ナノ粒子曝露がDNAメチル化へおよぼす影響解析2017
- Author(s)
  東阪和馬, 真木彩花, 青山道彦, 桑形麻樹子, 齋藤　滋, 吉岡靖雄, 長野一也, 堤　康央
- Organizer
  第44回日本毒性学会学術年会
- Data Source
  KAKENHI-PROJECT-16K01437
[Presentation] ナノ銀粒子曝露によるDNAメチル化酵素への影響2016
- Author(s)
  真木彩花, 東阪和馬, 青山道彦, 西川雄樹, 石坂拓也, 笠原淳平, 長野一也, 吉岡靖雄, 堤　康央
- Organizer
  第43回日本毒性学会学術年会
- Place of Presentation
  ウインクあいち（愛知県名古屋市）
- Year and Date
  2016-06-29
- Data Source
  KAKENHI-PROJECT-16K01437
[Presentation] 非晶質ナノシリカ曝露が宿主生体防御システムにおよぼす影響解析2013
- Author(s)
  國枝章義, 東阪和馬, 永野貴士, 岩原有希, 田中康太, 畑　勝友, 角田慎一, 吉岡靖雄, 堤　康央
- Organizer
  第40回日本毒性学会
- Place of Presentation
  幕張メッセ（千葉）
- Data Source
  KAKENHI-PROJECT-25750194
[Presentation] Evaluation of nanomaterial-induced biological responses by toxico-proteomics analysis2013
- Author(s)
  Higashisaka K., Kunieda A., Iwahara Y., Tanaka K., Tsunoda S., Yoshioka Y., Tsutsumi Y.
- Organizer
  HUPO 12th Annual World Congress
- Place of Presentation
  パシフィコ横浜（神奈川）
- Data Source
  KAKENHI-PROJECT-25750194
[Presentation] 薬学新素材としてのナノマテリアルの生体防御機構に及ぼす影響解析2013
- Author(s)
  東阪和馬, 國枝章義, 岩原有希, 田中康太, 畑　勝友, 角田慎一, 吉岡靖雄, 堤　康央
- Organizer
  第63回日本薬学会近畿支部総会・大会
- Place of Presentation
  同志社女子大学（京都）
- Data Source
  KAKENHI-PROJECT-25750194
[Presentation] Nano-Safety Science for ensuring safety of nanomaterials ~Biological assessment of silica nanoparticles focused on neutrophil~.
- Author(s)
  Higashisaka K., Kunieda A., Iwahara Y., Tanaka K., Tsunoda S., Yoshioka Y., Tsutsumi Y.
- Organizer
  Nanotech2014.
- Place of Presentation
  Washington DC (USA)
- Year and Date
  2014-06-15 – 2014-06-19
- Data Source
  KAKENHI-PROJECT-25750194
[Presentation] Biological assessment of silica nanoparticles focused on neutrophil for ensuring safety of nanomaterials.
- Author(s)
  Higashisaka K., Kunieda A., Iwahara Y., Tanaka K., Namba Y., Nishikawa Y., Tsunoda S., Yoshioka Y., Tsutsumi Y.
- Organizer
  5th FIP Pharmaceutical Sciences World Congress (PSWC)
- Place of Presentation
  Melbourne (Australia)
- Year and Date
  2014-04-13 – 2014-05-16
- Data Source
  KAKENHI-PROJECT-25750194

1. MATSUMOTO HIROSHI (60263092)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
2. 杉本香奈 (00581034)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
3. 原田和生 (50397741)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
4. 宮下洋平 (60816312)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
5. 吉澤秀憲 (90739905)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
6. 山田知美 (60363371)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
7. Maki Ayaka

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
8. Lin Ying

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
9. Sato Kenta

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
10. KATADA Ryuichi

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results
11. NAGANO Kazuya

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
12. 松下賢治

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Higashisaka Kazuma 東阪 和馬

HIGASHISAKA Kazuma 東阪 和馬

Research Projects

Research Products

Co-Researchers

プラスチック微粒子のリスク解析に向けた胎盤毒性の評価と機序解明Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Development of placental toxicity evaluation method for chemical substances and investigation of next-generation's healthPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Immunotoxicity assessment of nanoparticles and development into risk analysisPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Effects of nanoparticles on the central nervous system and the onset of depressionPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Challenge for prevention of sudden unexplained death : Elucidation of molecular mechanisms of death by transomics analysis

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Elucidation of the mechanism of nanoparticle-induced biological effects focusing on epigenetic regulationPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Identification of biomarkers for development of the efficacy and safety of nanomaterialsPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] Molecular mechanism of cerebral edema improvement via IL-1RA released from stroke-unaffected hindlimb by treadmill exercise after cerebral infarction in rats2023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Barium-induced toxic anterior segment syndrome2021

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Molecular mechanisms of Wischnewski spot development on gastric mucosa in fatal hypothermia: an experimental study in rats2020

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Activated microglia-derived macrophage-like cells exacerbate brain edema after ischemic stroke correlate with astrocytic expression of aquaporin-4 and interleukin-1 alpha release2020

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Silver Nanoparticles Induce DNA Hypomethylation through Proteasome-Mediated Degradation of DNA Methyltransferase 12020

Author(s)

Journal Title

DOI

NAID

ISSN

Year and Date

Language

Data Source

[Journal Article] Optimization and Evaluation of Pretreatment Method for sp-ICP-MS to Reveal the Distribution of Silver Nanoparticles in the Body2019

Author(s)

Journal Title

DOI

Higashisaka Kazuma 東阪和馬

HIGASHISAKA Kazuma 東阪和馬