Kitamura Hiroshi 北村大志

Researcher Number	20706949
Other IDs
Affiliation (Current)	2025: 東北医科薬科大学, 医学部, 講師
Affiliation (based on the past Project Information) *help	2021 – 2025: 東北医科薬科大学, 医学部, 助教 2019 – 2022: 東北大学, 未来型医療創成センター, 助教 2017 – 2018: 東北大学, スマート・エイジング学際重点研究センター, 助教 2015: 東北大学, 加齢医学研究所, 助教 2014: 東北大学, 加齢医学研究所, 教育研究支援者
Review Section/Research Field	Principal Investigator General medical chemistry / Basic Section 58020:Hygiene and public health-related: including laboratory approach / Basic Section 50010:Tumor biology-related / Basic Section 49010:Pathological biochemistry-related Except Principal Investigator Basic Section 47060:Clinical pharmacy-related / Basic Section 49060:Virology-related / Basic Section 49010:Pathological biochemistry-related
Keywords	Principal Investigator NRF2 / NRF2依存性がん / 腫瘍微小環境 / 肺がん / KEAP1 / 酸化ストレス / 転写因子ネットワーク / KRAS / 転写因子 / メタボローム … More / 代謝 / 代謝物 / 腫瘍免疫 / p16 / 老化 / 恒常的NRF2活性化 / 細胞老化 / Cdkn2a / ストレス防御 / GSH / ホルムアルデヒド / ヒストン脱メチル化 / グルタチオン / FDH … More Except Principal Investigator 診断薬 / 検査薬 / 生理活性ペプチド / 痒み / バイオマーカー / 遺伝子発現制御 / 基本転写因子 / 複製 / 転写 / BcRF1 / RNAポリメラーゼII / 複製コンパートメント / EBウイルス / メタボリックシンドローム / 肥満 / 代謝性疾患 / 炎症性反応 / マクロファージ / 炎症 / エクソソーム / エネルギー代謝性疾患 / 細胞外小胞 / 慢性炎症 Less

EBウイルス「トランスユーラシア」株の機能検証とアジア固有疾患への関与Principal Investigator
- Principal Investigator
  
  北村大志
- Project Period (FY)
  2025 – 2027
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 58020:Hygiene and public health-related: including laboratory approach
- Research Institution
  Tohoku Medical and Pharmaceutical University
Evaluation of novel biomarkers using peptides in pruritic processing
- Principal Investigator
  
  中山留美 (直野留美)
- Project Period (FY)
  2024 – 2026
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 47060:Clinical pharmacy-related
- Research Institution
  Tohoku Medical and Pharmaceutical University
ウイルス性基本転写因子の核内集積から解き明かす新たな遺伝子発現制御機構の解明
- Principal Investigator
  
  神田輝
- Project Period (FY)
  2022 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 49060:Virology-related
- Research Institution
  Tohoku Medical and Pharmaceutical University
NRF2依存性がんに脆弱性をもたらす転写因子ネットワークの変化Principal Investigator
- Principal Investigator
  
  北村大志
- Project Period (FY)
  2022 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 50010:Tumor biology-related
- Research Institution
  Tohoku Medical and Pharmaceutical University
The molecular basis for exosome-induced inflammatory responses
- Principal Investigator
  
  Nakamura Takahisa
- Project Period (FY)
  2020 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 49010:Pathological biochemistry-related
- Research Institution
  Tohoku University
The mechanistic analyses of modulation of Tumor microenvironment by characteristic metabolite released from NRF2-addicted cancer cellsPrincipal Investigator
- Principal Investigator
  
  Kitamura Hiroshi
- Project Period (FY)
  2019 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 49010:Pathological biochemistry-related
- Research Institution
  Tohoku Medical and Pharmaceutical University
  Tohoku University
Verification of the significance and the molecular mechanism of cellular senescence induced by constitutive NRF2 activationPrincipal Investigator
- Principal Investigator
  
  Kitamura Hiroshi
- Project Period (FY)
  2017 – 2018
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  General medical chemistry
- Research Institution
  Tohoku University
Analysis of molecular mechanisms for nuclear redox maintenance system to support epigenome regulationPrincipal Investigator
- Principal Investigator
  
  Kitamura Hiroshi
- Project Period (FY)
  2014 – 2015
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  General medical chemistry
- Research Institution
  Tohoku University

All 2023 2022 2021 2020 2019 2018 2017 2015 2014 Other

All Journal Article Presentation Book Other

[Book] NRF2依存性難治がんの成立機構とその特性2018
- Author(s)
  北村大志、本橋ほづみ
- Total Pages
  6
- Publisher
  実験医学
- Data Source
  KAKENHI-PROJECT-17K15591
[Book] NRF2依存性難治がんの成立機構とその特性2018
- Author(s)
  北村大志　本橋ほづみ
- Publisher
  羊土社
- Data Source
  KAKENHI-PROJECT-17K15591
[Book] Keap1-Nrf2経路の遺伝子変異とがん代謝2014
- Author(s)
  北村大志　本橋ほづみ
- Total Pages
  229
- Publisher
  羊土社
- Data Source
  KAKENHI-PROJECT-26860180
[Journal Article] Establishment of Neh2-Cre:tdTomato reporter mouse for monitoring the exposure history to electrophilic stress2022
- Author(s)
  Hiroshi Kitamura, Tetsuya Oishi, Shohei Murakami, Tomoe Yamada-Kato, Isao Okunishi, Masayuki Yamamoto, Yukio Katori, Hozumi Motohashi
- Journal Title
  
  Free Radic Biol Med
  
  Volume: 193 Pages: 610-619
- DOI
  10.1016/j.freeradbiomed.2022.11.004
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-22K07204, KAKENHI-PROJECT-21K16825, KAKENHI-ORGANIZER-21H05258, KAKENHI-PLANNED-21H05264, KAKENHI-PROJECT-21H04799, KAKENHI-PROJECT-19K07379, KAKENHI-PROJECT-21K15358
[Journal Article] Genetic, metabolic and immunological features of cancers with NRF2 addiction2022
- Author(s)
  Hiroshi Kitamura, Haruna Takeda, Hozumi Motohashi
- Journal Title
  
  FEBS Lett.
  
  Volume: 596 Issue: 16 Pages: 1981-1993
- DOI
  10.1002/1873-3468.14458
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-22K07204, KAKENHI-ORGANIZER-21H05258, KAKENHI-PLANNED-21H05264, KAKENHI-PROJECT-21H04799, KAKENHI-PROJECT-19K07379
[Journal Article] Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 directly binds and stabilizes Nrf2 in breast cancer.2022
- Author(s)
  Saeidi S, Kim SJ, Guillen-Quispe YN, Jagadeesh ASV, Han HJ, Kim SH, Zhong X, Piao JY, Kim SJ, Jeong J, Shin YJ, Cha YJ, Lee HB, Han W, Min SH, Tian W, Kitamura H, Surh YJ
- Journal Title
  
  FASEB J
  
  Volume: 36 Issue: 1 Pages: 1-16
- DOI
  10.1096/fj.202100776rr
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K07379
[Journal Article] Enhancer remodeling promotes tumor-initiating activity in NRF2-activated non-small cell lung cancers2020
- Author(s)
  Okazaki Keito、Anzawa Hayato、Liu Zun、Ota Nao、Kitamura Hiroshi、Onodera Yoshiaki、Alam Md. Morshedul、Matsumaru Daisuke、et al.
- Journal Title
  
  Nature Communications
  
  Volume: 11 Issue: 1 Pages: 5911-5911
- DOI
  10.1038/s41467-020-19593-0
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K07361, KAKENHI-PROJECT-19K07379, KAKENHI-PROJECT-19K09065, KAKENHI-PROJECT-20K16350, KAKENHI-PUBLICLY-20H04832, KAKENHI-PROJECT-19H05649, KAKENHI-PROJECT-18H02621, KAKENHI-PROJECT-17K08617
[Journal Article] Microenvironmental activation of Nrf2 restricts the progression of Nrf2-activated malignant tumors2020
- Author(s)
  Makiko Hayashi, Ayumi Kuga, Mikiko Suzuki, Harit Panda, Hiroshi Kitamura, Hozumi Motohashi, Masayuki Yamamoto
- Journal Title
  
  Cancer Research
  
  Volume: 0 Issue: 16 Pages: 00-00
- DOI
  10.1158/0008-5472.can-19-2888
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17J04895, KAKENHI-PROJECT-19K07379, KAKENHI-PUBLICLY-20H04832, KAKENHI-PROJECT-19H05649, KAKENHI-PROJECT-18H02621
[Journal Article] Autophagy regulates lipid metabolism through selective turnover of NCoR12019
- Author(s)
  Saito Tetsuya、Kuma Akiko、Sugiura Yuki、Ichimura Yoshinobu、Obata Miki、Kitamura Hiroshi、Okuda Shujiro、Lee Hyeon-Cheol、Ikeda Kazutaka、Kanegae Yumi、Saito Izumu、Auwerx Johan、Motohashi Hozumi、Suematsu Makoto、Soga Tomoyoshi、Yokomizo Takehiko、Waguri Satoshi、Mizushima Noboru、Komatsu Masaaki
- Journal Title
  
  Nature Communications
  
  Volume: 10 Issue: 1 Pages: 41467-41467
- DOI
  10.1038/s41467-019-08829-3
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-ORGANIZER-15H05897, KAKENHI-PROJECT-17J05623, KAKENHI-PROJECT-16H06276, KAKENHI-PROJECT-19K07379, KAKENHI-PUBLICLY-18H04794, KAKENHI-PROJECT-18H02621, KAKENHI-PROJECT-18F18099, KAKENHI-PROJECT-18H02611
[Journal Article] NRF2 addiction in cancer cells2018
- Author(s)
  Kitamura H and Motohashi H
- Journal Title
  
  Cancer Science
  
  Volume: 109 Issue: 4 Pages: 900-911
- DOI
  10.1111/cas.13537
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K15591, KAKENHI-PUBLICLY-18H04794, KAKENHI-PROJECT-18H02621, KAKENHI-PROJECT-17F17116, KAKENHI-PROJECT-17K19508
[Journal Article] NRF2 and HSF1 coordinately regulate heme oxygenase-1 expression.2018
- Author(s)
  Inouye S, Hatori Y, Kubo T, Saito S, Kitamura H, Akagi R.
- Journal Title
  
  Biochem Biophys Res Commun
  
  Volume: 506 Pages: 7-11
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17K15591
[Journal Article] IL-11 contribution to tumorigenesis in an NRF2 addiction cancer model2017
- Author(s)
  Kitamura H、Onodera Y、Murakami S、Suzuki T、Motohashi H
- Journal Title
  
  Oncogene
  
  Volume: 36 Issue: 45 Pages: 6315-6324
- DOI
  10.1038/onc.2017.236
- NAID
  130007902444
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17K19508, KAKENHI-PROJECT-17K15591, KAKENHI-PROJECT-15H04692, KAKENHI-PROJECT-17F17116
[Journal Article] Glucocorticoid receptor signaling represses the antioxidant response by inhibiting histone acetylation mediated by the transcriptional activatpr NRF22017
- Author(s)
  Alam MM, Okazaki K, Nguyen LTT, Ota N, Kitamura H, Murakami S, Shima H, Igarashi K, Sekine H, Motohashi H
- Journal Title
  
  J Biol Chem
  
  Volume: 印刷中 Issue: 18 Pages: 7519-7530
- DOI
  10.1074/jbc.m116.773960
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15H04692, KAKENHI-PROJECT-16K15228, KAKENHI-PROJECT-17K15591, KAKENHI-PROJECT-15H02506, KAKENHI-PROJECT-17K08618
[Journal Article] Activation of the NRF2 pathway and its impact on the prognosis of anaplastic glioma patients.2015
- Author(s)
  Kanamori M*, Higa T, Sonoda Y, Murakami S, Dodo M, Kitamura H, Taguchi K, Shibata T, Watanabe M, Suzuki H, Shibahara I, Saito R, Yamashita Y, Kumabe T, Yamamoto M, Motohashi H*, and Tominaga T.
- Journal Title
  
  Neuro-Oncology
  
  Volume: 17 Issue: 4 Pages: 555-565
- DOI
  10.1093/neuonc/nou282
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PLANNED-23116002, KAKENHI-PROJECT-24249015, KAKENHI-PROJECT-24390075, KAKENHI-PUBLICLY-25117703, KAKENHI-PROJECT-25670613, KAKENHI-PLANNED-26111002, KAKENHI-PROJECT-26460384, KAKENHI-PROJECT-26670150, KAKENHI-PROJECT-26860180
[Journal Article] The actin family protein ARP6 contributes to the structure and the function of the nucleolus.2015
- Author(s)
  Kitamura H, Matsumori H, Kalendova A, Hozak P, Goldberg IG, Nakao M, Saitoh N, Harata M.
- Journal Title
  
  Biochem Biophys Res Commun.
  
  Volume: 464 Pages: 554-560
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26860180
[Journal Article] Alcohol dehydrogenase 3 contributes to the protection of liver from nonalcoholic steatohepatitis.2015
- Author(s)
  Goto M, Kitamura H, Alam MM, Ota N, Haseba T, Akimoto T, Shimizu A, Takano-Yamamoto T, Yamamoto M, Motohashi H.
- Journal Title
  
  Genes Cells
  
  Volume: - Issue: 6 Pages: 464-480
- DOI
  10.1111/gtc.12237
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PLANNED-26111002, KAKENHI-PROJECT-26860180
[Presentation] EBウイルスゲノムの東アジアにおける地域差に関する解析2023
- Author(s)
  北村大志, 矢島美彩子, 生田和史, 神田輝
- Organizer
  第75回日本細菌学会東北支部総会・学術集会
- Data Source
  KAKENHI-PROJECT-22K07204
[Presentation] 全長ウイルスゲノム配列による東アジア地域EBウイルス株の系統解析2023
- Author(s)
  北村大志, 矢島美彩子, 生田和史, 神田輝
- Organizer
  第70回ウイルス学会学術集会
- Data Source
  KAKENHI-PROJECT-22K07204
[Presentation] 全長ウイルスゲノム配列による東アジア地域EBウイルス株の系統解析2023
- Author(s)
  北村大志, 生田和史, 矢島美彩子, 神田輝
- Organizer
  第70回　日本ウイルス学会学術集会
- Data Source
  KAKENHI-PROJECT-22K07090
[Presentation] 東アジアにおけるEB ウイルスゲノムの地域差に関する解析2023
- Author(s)
  北村大志, 矢島美彩子, 生田和史, 神田輝
- Organizer
  第36回ヘルペスウイルス研究会
- Data Source
  KAKENHI-PROJECT-22K07204
[Presentation] 胚盤特異的マイクロRNA群が誘導するサイトメガロウイルスの産生2023
- Author(s)
  生田和史, 矢島美彩子, 北村大志, 神田輝
- Organizer
  第70回ウイルス学会学術集会
- Data Source
  KAKENHI-PROJECT-22K07204
[Presentation] 胎盤由来マイクロRNA 群によるサイトメガロウイルス感染の誘導2023
- Author(s)
  生田和史, 矢島美彩子, 北村大志, 神田輝
- Organizer
  第36回ヘルペスウイルス研究会
- Data Source
  KAKENHI-PROJECT-22K07204
[Presentation] 胎盤特異的マイクロRNA群が誘導するサイトメガロウイルスの産生2023
- Author(s)
  生田和史, 矢島美彩子, 北村大志, 神田輝
- Organizer
  第70回　日本ウイルス学会学術集会
- Data Source
  KAKENHI-PROJECT-22K07090
[Presentation] 先天性サイトメガロウイルス感染における胎盤由来マイクロRNA群の役割2023
- Author(s)
  生田和史, 矢島美彩子, 北村大志, 神田輝
- Organizer
  日本細菌学会東北支部総会・学術集会 2023年8月21日
- Data Source
  KAKENHI-PROJECT-22K07204
[Presentation] EBウイルスゲノムの東アジア地域間における多様性に関する系統解析2023
- Author(s)
  北村大志, 矢島美彩子, 生田和史, 神田輝
- Organizer
  第31回EBV感染症研究会
- Data Source
  KAKENHI-PROJECT-19K07379
[Presentation] EBウイルスゲノムの東アジア地域間における多様性に関する系統解析2023
- Author(s)
  北村大志、矢島美彩子、生田和史, 神田輝
- Organizer
  第31回EBV感染症研究会
- Data Source
  KAKENHI-PROJECT-22K07204
[Presentation] Epstein-Barr virus strains transmitted among Transeurasian language speakers2023
- Author(s)
  Hiroshi Kitamura, Iwao Kukimoto, Misako Yajima, Teru Kanda
- Organizer
  The Joint 24th International Conference on Emerging Infectious Diseases in the Pacific Rim
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-22K07090
[Presentation] EBV複製時におけるhost-shutoffとRNAポリメラーゼIIの機能修飾2022
- Author(s)
  神田輝, 北村大志
- Organizer
  第81回日本癌学会学術総会
- Data Source
  KAKENHI-PROJECT-22K07204
[Presentation] 胎盤栄養膜由来microRNA群によるサイトメガロウイルス産生の誘導2022
- Author(s)
  生田和史, 矢島美彩子, 北村大志, 神田輝
- Organizer
  第46回国際ヘルペスウイルスワークショップ
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-22K07204
[Presentation] 胎盤で高発現するmicroRNA群によるサイトメガロウイルス産生の誘導2022
- Author(s)
  生田和史, 矢島美彩子, 北村大志, 神田輝
- Organizer
  第74回日本細菌学会東北支部会学術集会・総会
- Data Source
  KAKENHI-PROJECT-22K07204
[Presentation] 胎盤栄養膜由来microRNA群によるサイトメガロウイルス産生の誘導2022
- Author(s)
  生田和史, 矢島美彩子, 北村大志, 神田輝
- Organizer
  第69回日本ウイルス学会学術集会
- Data Source
  KAKENHI-PROJECT-22K07204
[Presentation] EBV複製時におけるhost-shutoffとRNAポリメラーゼIIの機能修飾2022
- Author(s)
  神田輝, 北村大志
- Organizer
  第81回日本癌学会学術総会
- Data Source
  KAKENHI-PROJECT-19K07379
[Presentation] Establishment of a transgenic mouse line for monitoring exposure history to electrophilic stress.2022
- Author(s)
  Hiroshi Kitamura, Tetsuya Oishi, Shohei Murakami, Yukio Katori, Hozumi Motohashi.
- Organizer
  第155回東北大学加齢医学研究所　集談会
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K07379
[Presentation] マウス胎児線維芽細胞を用いたNRF2活性化腫瘍モデルの作成2022
- Author(s)
  飯田謙人, 岡崎慶斗北村大志, 村上昌平, 本橋ほづみ
- Organizer
  第81回日本癌学会学術総会
- Data Source
  KAKENHI-PROJECT-22K07204
[Presentation] 胎盤栄養膜由来microRNA群によるサイトメガロウイルス産生の誘導2022
- Author(s)
  生田和史, 矢島美彩子, 北村大志, 神田輝
- Organizer
  第46回国際ヘルペスウイルスワークショップ
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K07379
[Presentation] マウス胎児線維芽細胞を用いたNRF2活性化腫瘍モデルの作成2022
- Author(s)
  北村大志, 神田輝, 本橋ほづみ
- Organizer
  第81回日本癌学会学術総会
- Data Source
  KAKENHI-PROJECT-19K07379
[Presentation] 胎盤で高発現するmicroRNA群によるサイトメガロウイルス産生の誘導2022
- Author(s)
  生田和史, 矢島美彩子, 北村大志, 神田輝
- Organizer
  第74回日本細菌学会東北支部会学術集会・総会
- Data Source
  KAKENHI-PROJECT-19K07379
[Presentation] NRF2依存性がんの脆弱性を生み出す因子の解析2022
- Author(s)
  北村大志, 神田輝, 本橋ほづみ
- Organizer
  第81回日本癌学会学術総会
- Data Source
  KAKENHI-PROJECT-22K07204
[Presentation] Inhibition of xCT,cystine/glutamate transporter, supresses chronic inflammation in a mouse model of inflammatory bowel disease2022
- Author(s)
  岩城英也, 関根弘樹, 村上昌平, 加藤伸史, 北村大志, 福田真嗣, 曽我朋義, 角田洋一, 正宗淳, 本橋ほづみ
- Organizer
  The 12th International Conference on the Biology, Chemistry, and Therapeutic Applications of Nitric Oxide
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K07379
[Presentation] 改変コンディショナルリプログラミング法によるEBウイルス陽性胃がん細胞株化の試み2022
- Author(s)
  神田輝, 北村大志, 生田和史, 清野透
- Organizer
  第69回日本ウイルス学会学術集会
- Data Source
  KAKENHI-PROJECT-22K07204
[Presentation] 改変コンディショナルリプログラミング法によるEBウイルス陽性胃がん細胞株化の試み2022
- Author(s)
  神田輝、北村大志、生田和史、清野透
- Organizer
  第69回　日本ウイルス学会学術集会
- Data Source
  KAKENHI-PROJECT-22K07090
[Presentation] Inhibition of xCT,cystine/glutamate transporter, supresses chronic inflammation in a mouse model of inflammatory bowel disease2022
- Author(s)
  岩城英也, 関根弘樹, 村上昌平, 加藤伸史, 北村大志, 福田真嗣, 曽我朋義, 角田洋一, 正宗淳, 本橋ほづみ
- Organizer
  The 12th International Conference on the Biology, Chemistry, and Therapeutic Applications of Nitric Oxide
- Data Source
  KAKENHI-PROJECT-22K07204
[Presentation] EBV複製細胞におけるhost-shutoffとRNAポリメラーゼIIの機能修飾2022
- Author(s)
  神田輝、北村大志
- Organizer
  第81回　日本癌学会学術総会
- Data Source
  KAKENHI-PROJECT-22K07090
[Presentation] 改変コンディショナルリプログラミング法によるEBウイルス陽性胃がん細胞株化の試み2022
- Author(s)
  神田輝, 北村大志, 生田和史, 清野透
- Organizer
  第69回日本ウイルス学会学術集会
- Data Source
  KAKENHI-PROJECT-19K07379
[Presentation] 胎盤栄養膜由来microRNA群によるサイトメガロウイルス産生の誘導2022
- Author(s)
  生田和史, 矢島美彩子, 北村大志, 神田輝
- Organizer
  第69回日本ウイルス学会学術集会
- Data Source
  KAKENHI-PROJECT-19K07379
[Presentation] 炎症性腸疾患におけるシスチントランスポーターxCTの機能解析2021
- Author(s)
  加藤伸史、北村大志、村上昌平、河部剛史、石井直人、亀井尚、本橋ほづみ
- Organizer
  日本生化学会東北支部第87回例会
- Data Source
  KAKENHI-PROJECT-19K07379
[Presentation] Establishment of a transgenic mouse line for monitoring exposure history to electrophilic stress2021
- Author(s)
  Hiroshi Kitamura, Yoshiaki Onodera, Takashi Suzuki, Hozumi Motohashi.
- Organizer
  155th IDAC Bi Annual Meeting,
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K07379
[Presentation] 親電子性ストレス曝露履歴モニタリングマウスの樹立2021
- Author(s)
  北村大志、大石哲也、村上昌平、香取幸夫、本橋ほづみ
- Organizer
  第94回日本生化学会大会
- Data Source
  KAKENHI-PROJECT-19K07379
[Presentation] 炎症性腸疾患におけるシスチントランスポーターxCTの機能解析2021
- Author(s)
  加藤伸史、北村大志、村上昌平、河部剛史、石井直人、亀井尚、本橋ほづみ
- Organizer
  第94回日本生化学会大会
- Data Source
  KAKENHI-PROJECT-19K07379
[Presentation] Establishment of a transgenic mouse line for monitoring exposure history to electrophilic stress2020
- Author(s)
  Hiroshi Kitamura, Tetsuya Oishi, Tomoe Kato, Isao Okunishi, Hozumi Motohashi.
- Organizer
  AAIC20
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K07379
[Presentation] KEAP1の抑制によるNRF2経路の活性化がもたらす加齢性難聴の予防効果の検討2020
- Author(s)
  大石哲也、松丸大輔、北村大志、本蔵陽平、香取幸夫、本橋ほづみ
- Organizer
  日本生化学会東北支部　第86回例会
- Data Source
  KAKENHI-PROJECT-19K07379
[Presentation] 非小細胞性肺がんにおけるエンハンサーリモデリングによるNRF2-NOTCH3経路の活性化と幹細胞性への貢献．2019
- Author(s)
  岡崎慶斗、安澤隼人、北村大志、小野寺好明、Md. Morshedul Alam、松丸大輔、太田奈緒、桜田晃、岡田克典、勝岡史城、山本雅之、鈴木貴、木下賢吾、関根弘樹、本橋ほづみ
- Organizer
  日本生化学会東北支部　第85回例会
- Data Source
  KAKENHI-PROJECT-19K07379
[Presentation] 酸化ストレスに対するNRF2活性化履歴モニタリングマウスの作成2019
- Author(s)
  大石哲也、北村大志、香取幸夫、本橋ほづみ
- Organizer
  第72回日本酸化ストレス学会学術集会
- Data Source
  KAKENHI-PROJECT-19K07379
[Presentation] Enhancer remodeling at the NOTCH3 locus licenses NRF2 for the promotion of a stem-like phenotype in non-small cell lung cancers.2019
- Author(s)
  Keito Okazaki, Hayato Anzawa, Hiroshi Kitamura, Yoshiaki Onodera, Md. Morshedul Alam, Daisuke Matsumaru, Takuma Suzuki, Fumiki Katsuoka, Nao Ota, Akira Sakurada, Yoshinori Okada, Masayuki Yamamoto, Takashi Suzuki, Kengo Kinoshita, Hiroki Sekine, Hozumi Motohashi.
- Organizer
  The Environmental Response V
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K07379
[Presentation] Establoshment of a transgenic mouse line for monitoring exposure history to electrophilic stress.2019
- Author(s)
  Tetsuya Oishi, Hiroshi Kitamura, Yukio Katori, Hozumi Motohashi.
- Organizer
  The Environmental Response V
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K07379
[Presentation] Establishment of a transgenic mouse line for monitoring exposure history to electrophilic stress.2019
- Author(s)
  Tetsuya Oishi, Hiroshi Kitamura, Yukio Katori, Hozumi Motohashi.
- Organizer
  The 9th Biennial Meeting of Society for Free Radical Research-Asia (SFRR-Asia).
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K07379
[Presentation] 酸化ストレスに対するNRF2活性化履歴モニタリングマウスの作成．2019
- Author(s)
  大石哲也、北村大志、香取幸夫、本橋ほづみ．
- Organizer
  本生化学会東北支部　第85回例会
- Data Source
  KAKENHI-PROJECT-19K07379
[Presentation] NRF2による生体防御とがんの悪性化2018
- Author(s)
  本橋ほづみ、井田智章、Md. Morshedul Alam、北村大志、赤池孝章
- Organizer
  第71回日本酸化ストレス学会・日本NO学会合同学術集会
- Data Source
  KAKENHI-PROJECT-17K15591
[Presentation] NRF2依存性がんにおけるIL11の貢献　創生応用医学研究センター2018
- Author(s)
  北村大志
- Organizer
  第１回若手研究者交流会　星陵オーディトリウム
- Invited
- Data Source
  KAKENHI-PROJECT-17K15591
[Presentation] NRF2依存性モデルがん細胞におけるIL-11の貢献.2018
- Author(s)
  北村大志，小野寺好明，村上昌平，鈴木貴，本橋ほづみ
- Organizer
  日本生化学会東北支部第84回例会・シンポジウム
- Invited
- Data Source
  KAKENHI-PROJECT-17K15591
[Presentation] Electrophilic response and sulfur metabolism regulated by KEAP1-NRF2 system.2018
- Author(s)
  Hozumi Motohashi, Tomoaki Ida, Md. Morshedul Alam, Hiroshi Kitamura, Takaaki Akaike
- Organizer
  第91回日本生化学会大会　国立京都国際会館
- Data Source
  KAKENHI-PROJECT-17K15591
[Presentation] Glucocorticoid receptor signaling represses antioxidant response by inhibiting NRF2-dependent histone acetylation.2017
- Author(s)
  Md. Morshedul Alam, Keito Okazaki, Nao Ota, Hiroshi Kitamura, Hiroki Shima, Kazuhiko Igarashi, Hiroki Sekine, Hozumi Motohashi.
- Organizer
  日本生化学会東北支部会第83回例会
- Data Source
  KAKENHI-PROJECT-17K15591
[Presentation] IL-11 contributes to tumorigenesis in an NRF２ addiction cancer model2017
- Author(s)
  Hiroshi Kitamura， Yoshiaki Onodera， Takashi Suzuki， Hozumi Motohashi．
- Organizer
  SfRBM 24th Annual Meeting
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K15591
[Presentation] KEAP1遺伝子変異はRASシグナルと協調して腫瘍形成を促進する．2015
- Author(s)
  北村大志、本橋ほづみ
- Organizer
  第３８回日本分子生物学会年会／第８８回日本生化学会大会合同大会
- Place of Presentation
  神戸ポートアイランド．神戸
- Year and Date
  2015-12-01
- Data Source
  KAKENHI-PROJECT-26860180
[Presentation] グルタチオン依存性ホルムアルデヒド脱水素酵素ADH3による酸化ストレス防御と代謝制御2015
- Author(s)
  後藤まき、北村大志、Md. Morshedul Alam、長谷場健、山本照子、山本雅之、笠松真吾、井田智章、赤池孝章、本橋ほづみ．
- Organizer
  Research PlaNet 2015
- Place of Presentation
  梅田スカイビルタワー・ウェスト　大阪
- Year and Date
  2015-06-20
- Data Source
  KAKENHI-PROJECT-26860180
[Presentation] Human ADH5 polymorphism affect susceptibility to electorphilic stresses.2015
- Author(s)
  Md. Morshedul Alam、後藤まき、北村大志、井田智章、赤池孝章、本橋ほづみ．
- Organizer
  日本生化学会東北支部第８１回例会
- Place of Presentation
  東北大学片平さくらホール．仙台
- Year and Date
  2015-05-09
- Data Source
  KAKENHI-PROJECT-26860180
[Presentation] 悪性神経膠腫におけるNRF2経路活性化と予後に関する検討．2015
- Author(s)
  金森政之、比嘉剛志、園田順彦、村上昌平、北村大志、百々美奈、柴田龍弘、渡辺みか、鈴木博義、柴原一陽、齋藤竜太、山下洋二、隈部俊宏、山本雅之、本橋ほづみ、冨永悌二
- Organizer
  第１６回日本分子脳神経外科学会
- Place of Presentation
  アクトシティ浜松コングレスセンター, 浜松
- Year and Date
  2015-08-28
- Data Source
  KAKENHI-PROJECT-26860180
[Presentation] Human ADH5 polymorphism affect susceptibility to electorphilic stresses.2015
- Author(s)
  Md. Morshedul Alam、後藤まき、北村大志、井田智章、赤池孝章、本橋ほづみ
- Organizer
  日本生化学会東北支部第８１回例会
- Place of Presentation
  東北大学片平さくらホール．仙台
- Year and Date
  2015-05-09
- Data Source
  KAKENHI-PROJECT-26860180
[Presentation] 転写因子Nrf2とグルタチオン依存性ホルムアルデヒド脱水素酵素Adh3による協調的生体防御機構
- Author(s)
  後藤まき, 北村大志, 澤智裕, 赤池孝章, 長谷場健, 秋元寿男, 山本照子, 山本雅之, 本橋ほづみ
- Organizer
  生命素子による転写環境とエネルギー代謝のクロストーク制御「転写代謝システム」ー平成26年度領域班会議ー
- Place of Presentation
  仙台　秋保温泉　岩沼屋
- Year and Date
  2014-07-11 – 2014-07-13
- Data Source
  KAKENHI-PROJECT-26860180
[Presentation] 生体防御における転写因子Nrf2とグルタチオン依存性ホルムアルデヒド脱水素酵素Adh3による協調作用
- Author(s)
  後藤まき、北村大志、井田智章、澤智裕、赤池孝章、長谷場健、秋元敏雄、山本（高野）照子、山本雅之、本橋ほづみ
- Organizer
  第８７回日本生化学会大会
- Place of Presentation
  京都　国立京都国際会館
- Year and Date
  2014-10-15 – 2014-10-18
- Data Source
  KAKENHI-PROJECT-26860180
[Presentation] Alcohol dehydrogenase 3 Cooperates with Keap1-Nrf2 system for Protection of Mouse Liver from Nonalcoholic Steatohepatitis
- Author(s)
  後藤まき、北村大志、長谷場健、秋元敏雄、山本照子、山本雅之、本橋ほづみ
- Organizer
  がんエピゲノム研究会　冬の合宿
- Place of Presentation
  仙台　秋保　リゾートホテルクレセント
- Year and Date
  2015-02-14 – 2015-02-15
- Data Source
  KAKENHI-PROJECT-26860180
[Presentation] IDH遺伝子変異がもたらすNRF2機能への影響の解析
- Author(s)
  北村大志, 百々美奈, 比嘉剛志, 金森政之, 本橋ほづみ
- Organizer
  生命素子による転写環境とエネルギー代謝のクロストーク制御「転写代謝システム」ー平成26年度領域班会議ー
- Place of Presentation
  仙台　秋保温泉　岩沼屋
- Year and Date
  2014-07-11 – 2014-07-13
- Data Source
  KAKENHI-PROJECT-26860180
[]
[]

1. Nakamura Takahisa (30396874)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
2. 本橋ほづみ (00282351)

# of Collaborated Projects: 1 results

# of Collaborated Products: 3 results
3. 谷貝知樹 (50868669)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
4. 神田輝 (50333472)

# of Collaborated Projects: 1 results

# of Collaborated Products: 5 results
5. 中山留美 (00609034)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
6. 生田和史 (60512184)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
7. 有田誠

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
8. 横溝岳彦

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
9. 山本雅之

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
10. 松丸大輔

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Kitamura Hiroshi 北村 大志

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EBウイルス「トランスユーラシア」株の機能検証とアジア固有疾患への関与Principal Investigator

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Evaluation of novel biomarkers using peptides in pruritic processing

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ウイルス性基本転写因子の核内集積から解き明かす新たな遺伝子発現制御機構の解明

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NRF2依存性がんに脆弱性をもたらす転写因子ネットワークの変化Principal Investigator

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The molecular basis for exosome-induced inflammatory responses

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The mechanistic analyses of modulation of Tumor microenvironment by characteristic metabolite released from NRF2-addicted cancer cellsPrincipal Investigator

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Verification of the significance and the molecular mechanism of cellular senescence induced by constitutive NRF2 activationPrincipal Investigator

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Analysis of molecular mechanisms for nuclear redox maintenance system to support epigenome regulationPrincipal Investigator

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[Book] NRF2依存性難治がんの成立機構とその特性2018

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[Book] NRF2依存性難治がんの成立機構とその特性2018

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[Book] Keap1-Nrf2経路の遺伝子変異とがん代謝2014

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[Journal Article] Establishment of Neh2-Cre:tdTomato reporter mouse for monitoring the exposure history to electrophilic stress2022

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[Journal Article] Genetic, metabolic and immunological features of cancers with NRF2 addiction2022

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[Journal Article] Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 directly binds and stabilizes Nrf2 in breast cancer.2022

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Kitamura Hiroshi 北村大志