Shinjo Takanori 新城尊徳

… Alternative Names

SHINJO Takanori 新城尊徳

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Researcher Number	20711394
Other IDs
Affiliation (Current)	2025: 九州大学, 歯学研究院, 助教
Affiliation (based on the past Project Information) *help	2024: 九州大学, 歯学研究科(研究院), 助教 2020 – 2024: 九州大学, 歯学研究院, 助教 2014: 九州大学, 大学病院, その他 2013: 広島大学, 大学病院, 歯科診療医
Review Section/Research Field	Principal Investigator Basic Section 57030:Conservative dentistry-related / Periodontology Except Principal Investigator Basic Section 57030:Conservative dentistry-related / Medium-sized Section 57:Oral science and related fields
Keywords	Principal Investigator 歯周炎 / 糖尿病 / 肥満 / 糸球体 / PGD2 / HPGDS / 歯周医学 / 糖尿病性腎症 / 白血球接着因子 / インスリン … More / VCAM-1 / インスリン作用 / FoxO1 / VCAM1 / 血管内皮細胞 / インスリン抵抗性 / 糖尿病関連歯周炎 / 脂肪 / 肝臓 / マクロファージ / 脂肪細胞 / DPP4阻害薬 / 抗炎症効果 … More Except Principal Investigator エクソソーム / 歯肉幹細胞 / 空間トランスクリプトーム / 歯周組織再生 / 日本人モデル / 健康寿命 / 腎症 / NASH / 歯周病 / 歯周炎 / miRNA / ERストレス / miR-1260b / CD73 / M2マクロファージ / 統合オミクス解析 / 遺伝子改変マウス / RNA-sequence / プロテオミクス / メタボロミクス / 糖尿病関連歯周炎 Less

日本人型軽度肥満モデルの歯周病と健康寿命
- Principal Investigator
  
  西村英紀
- Project Period (FY)
  2024 – 2026
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 57030:Conservative dentistry-related
- Research Institution
  Kyushu University
Spatial transcriptome analysis of GMSC-derived exoxme mediated peridontal tissue regneration
- Principal Investigator
  
  福田隆男
- Project Period (FY)
  2024 – 2027
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 57030:Conservative dentistry-related
- Research Institution
  Kyushu University
ヒト献体サンプルを用いた解析を軸とした歯周炎ー糖尿病性腎症連関機構の解明Principal Investigator
- Principal Investigator
  
  新城尊徳
- Project Period (FY)
  2024
- Research Category
  
  Fund for the Promotion of Joint International Research (Fostering Joint International Research)
- Review Section
  
  Basic Section 57030:Conservative dentistry-related
- Research Institution
  Kyushu University
The molecular mechanism in the association of periodontitis and diabetic nephropathy via PGD2 signalingPrincipal Investigator
- Principal Investigator
  
  新城尊徳
- Project Period (FY)
  2023 – 2025
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 57030:Conservative dentistry-related
- Research Institution
  Kyushu University
The possible role of insulin resistance in vascular endothelial cells on exacerbation of periodontitisPrincipal Investigator
- Principal Investigator
  
  Shinjo Takanori
- Project Period (FY)
  2020 – 2023
- Research Category
  
  Grant-in-Aid for Early-Career Scientists
- Review Section
  
  Basic Section 57030:Conservative dentistry-related
- Research Institution
  Kyushu University
統合オミクス解析を介した糖尿病性歯周炎の病態解明を目指す国際共同研究
- Principal Investigator
  
  西村英紀
- Project Period (FY)
  2020 – 2024
- Research Category
  
  Fund for the Promotion of Joint International Research (Fostering Joint International Research (B))
- Review Section
  
  Medium-sized Section 57:Oral science and related fields
- Research Institution
  Kyushu University
New therapeutic strategy for periodontal disease targeting exosomal miRNA derived from GMSCs.
- Principal Investigator
  
  Fukuda Takao
- Project Period (FY)
  2020 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 57030:Conservative dentistry-related
- Research Institution
  Kyushu University
A investigation into anti-inflammatory effect of SK-0403 via DPP4-inhibition.Principal Investigator
- Principal Investigator
  
  SHINJO Takanori
- Project Period (FY)
  2013 – 2014
- Research Category
  
  Grant-in-Aid for Research Activity Start-up
- Research Field
  
  Periodontology
- Research Institution
  Kyushu University
  Hiroshima University

All 2024 2023 2022 2021 2020 2014 Other

All Journal Article Presentation Book

[Book] 月刊糖尿病　2022年　特集肥満・糖尿病・歯周病インスリン抵抗性と歯周炎～新たな分子基盤～2022
- Author(s)
  新城尊徳
- Publisher
  医学出版株式会社
- Data Source
  KAKENHI-PROJECT-20K18513
[Book] FORUM 合併症Ⅰ歯周病歯周病と糖尿病の相互関係(2)　糖尿病プラクティス2022年9・10月号2022
- Author(s)
  新城尊徳
- Publisher
  医歯薬出版株式会社
- Data Source
  KAKENHI-PROJECT-20K18513
[Book] FORUM 合併症Ⅰ歯周病歯周病と糖尿病の相互関係(3)　糖尿病プラクティス2022年11・12月号2022
- Author(s)
  新城尊徳
- Publisher
  医歯薬出版株式会社
- Data Source
  KAKENHI-PROJECT-20K18513
[Book] FORUM 合併症Ⅰ歯周病歯周病と糖尿病の相互関係(1)　糖尿病プラクティス2022年7・8月号2022
- Author(s)
  新城尊徳
- Publisher
  医歯薬出版株式会社
- Data Source
  KAKENHI-PROJECT-20K18513
[Book] ファーマスタイル2022年　歯周病を知る－知っておきたい歯周病の知識と全身疾患との関連2022
- Author(s)
  新城尊徳、大山順子
- Publisher
  アルトマーク
- Data Source
  KAKENHI-PROJECT-20K18513
[Book] 糖尿病・内分泌代謝科　2022年（特集）口腔ケアと生活習慣病Up-to-date 歯周病と糖尿病及び糖尿病合併症との関連性2022
- Author(s)
  新城尊徳、西村英紀
- Publisher
  科学評論社
- Data Source
  KAKENHI-PROJECT-20K18513
[Book] 糖尿病合併症としての歯周病　糖尿病プラクティス9・10月号2020
- Author(s)
  新城尊徳
- Total Pages
  120
- Publisher
  医歯薬出版株式会社
- Data Source
  KAKENHI-PROJECT-20K18513
[Book] 第8章　糖尿病　ヒト常在菌層と生理機能・全身疾患2020
- Author(s)
  新城尊徳、西村英紀
- Total Pages
  325
- Publisher
  シーエムシー出版
- Data Source
  KAKENHI-PROJECT-20K18513
[Journal Article] Luteolin Is a Potential Immunomodulating Natural Compound against Pulpal Inflammation2024
- Author(s)
  Kawakami Kentaro、Fukuda Takao、Toyoda Masaaki、Nakao Yuki、Hayashi Chikako、Watanabe Yukari、Aoki Tsukasa、Shinjo Takanori、Iwashita Misaki、Yamashita Akiko、Shida Miyu、Sanui Terukazu、Uchiumi Takeshi、Nishimura Fusanori
- Journal Title
  
  BioMed Research International
  
  Volume: 2024 Pages: 1-16
- DOI
  10.1155/2024/8864513
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-23K16024, KAKENHI-PROJECT-22K21041, KAKENHI-PROJECT-23K19722, KAKENHI-PROJECT-20KK0212, KAKENHI-PROJECT-20H03865
[Journal Article] The bidirectional association between diabetes and periodontitis, from basic to clinical2024
- Author(s)
  Shinjo Takanori、Nishimura Fusanori
- Journal Title
  
  Japanese Dental Science Review
  
  Volume: 60 Pages: 15-21
- DOI
  10.1016/j.jdsr.2023.12.002
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20KK0212
[Journal Article] Epithelial-to-mesenchymal transition, inflammation, subsequent collagen production, and reduced proteinase expression cooperatively contribute to cyclosporin-A-induced gingival overgrowth development2023
- Author(s)
  Imagawa Mio、Shinjo Takanori、Sato Kohei、Kawakami Kentaro、Zeze Tatsuro、Nishimura Yuki、Toyoda Masaaki、Chen Shuang、Ryo Naoaki、Ahmed Al-kafee、Iwashita Misaki、Yamashita Akiko、Fukuda Takao、Sanui Terukazu、Nishimura Fusanori
- Journal Title
  
  Frontiers in Physiology
  
  Volume: 14 Pages: 01-16
- DOI
  10.3389/fphys.2023.1298813
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20KK0212, KAKENHI-PROJECT-21K09897, KAKENHI-PROJECT-23K09170, KAKENHI-PROJECT-20K09958, KAKENHI-PROJECT-20K18513, KAKENHI-PROJECT-20H03865, KAKENHI-PROJECT-23K27774
[Journal Article] miR-582-5p targets Skp1 and regulates NF-κB signaling-mediated inflammation2023
- Author(s)
  Li Rongzhi、Sano Tomomi、Mizokami Akiko、Fukuda Takao、Shinjo Takanori、Iwashita Misaki、Yamashita Akiko、Sanui Terukazu、Nakatsu Yusuke、Sotomaru Yusuke、Asano Tomoichiro、Kanematsu Takashi、Nishimura Fusanori
- Journal Title
  
  Archives of Biochemistry and Biophysics
  
  Volume: 734 Pages: 109501-109501
- DOI
  10.1016/j.abb.2022.109501
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-21K09897, KAKENHI-PROJECT-22K09904, KAKENHI-PROJECT-20K18512, KAKENHI-PROJECT-20H03732, KAKENHI-PROJECT-20H03865, KAKENHI-PROJECT-21K19380, KAKENHI-PROJECT-20KK0212, KAKENHI-PROJECT-23K09170, KAKENHI-PROJECT-21K09817, KAKENHI-PROJECT-20K18513, KAKENHI-PROJECT-23K27650
[Journal Article] Endothelial Insulin Resistance Exacerbates Experimental Periodontitis2023
- Author(s)
  Zeze T.、Shinjo T.、Sato K.、Nishimura Y.、Imagawa M.、Chen S.、Ahmed A.-k.、Iwashita M.、Yamashita A.、Fukuda T.、Sanui T.、Park K.、King G.L.、Nishimura F.
- Journal Title
  
  Journal of Dental Research
  
  Volume: 102 Issue: 10 Pages: 1152-1161
- DOI
  10.1177/00220345231181539
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20KK0212, KAKENHI-PROJECT-21K09897, KAKENHI-PROJECT-20K09958, KAKENHI-PROJECT-20K18513, KAKENHI-PROJECT-23K27774
[Journal Article] Dysregulation of CXCL1 Expression and Neutrophil Recruitment in Insulin Resistance and Diabetes-Related Periodontitis in Male Mice2023
- Author(s)
  Shinjo Takanori、Onizuka Satoru、Zaitsu Yumi、Ishikado Atsushi、Park Kyoungmin、Li Qian、Yokomizo Hisashi、Zeze Tatsuro、Sato Kohei、St-Louis Ronald、Fu Jialin、I-Hsien Wu、Mizutani Koji、Hasturk Hatice、Van Dyke Thomas E.、Nishimura Fusanori、King George L.
- Journal Title
  
  Diabetes
  
  Volume: 72 Issue: 7 Pages: 986-998
- DOI
  10.2337/db22-1014
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20KK0212, KAKENHI-PROJECT-23K09170, KAKENHI-PROJECT-20K18513
[Journal Article] Regeneration of glomerular metabolism and function by podocyte pyruvate kinase M2 in diabetic nephropathy2022
- Author(s)
  Fu Jialin、Shinjo Takanori、Li Qian、St-Louis Ronald、Park Kyoungmin、Yu Marc G.、Yokomizo Hisashi、Simao Fabricio、Huang Qian、Wu I-Hsien、King George L.
- Journal Title
  
  JCI Insight
  
  Volume: 7 Issue: 5
- DOI
  10.1172/jci.insight.155260
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K18513, KAKENHI-PROJECT-20KK0212
[Journal Article] Extracellular vesicles derived from GMSCs stimulated with TNF-α and IFN-α promote M2 macrophage polarization via enhanced CD73 and CD5L expression.2022
- Author(s)
  Watanabe Y, Fukuda T, Hayashi C, Nakao Y, Toyoda M, Kawakami K, Shinjo T, Iwashita M, Yamato H, Yotsumoto K, Taketomi T, Uchiumi T, Sanui T, Nishimura F.
- Journal Title
  
  Sci Rep
  
  Volume: 12(1) Issue: 1 Pages: 13344-13344
- DOI
  10.1038/s41598-022-17692-0
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K09958, KAKENHI-PROJECT-20K18513, KAKENHI-PROJECT-21K16972, KAKENHI-PROJECT-22K21041, KAKENHI-PROJECT-20H03865, KAKENHI-PROJECT-21K21017, KAKENHI-PROJECT-21K21089
[Journal Article] miR-1260b inhibits periodontal bone loss by targeting ATF6β mediated regulation of ER stress.2022
- Author(s)
  Hayashi C, Fukuda T, Kawakami K, Toyoda M, Nakao Y, Watanabe Y, Shinjo T, Sano T, Iwashita M, Yotsumoto K, Shida M, Taketomi T, Sanui T, Uchiumi T, Kanematsu T, Nishimura F.
- Journal Title
  
  Front Cell Dev Biol
  
  Volume: 10 Pages: 1061216-1061216
- DOI
  10.3389/fcell.2022.1061216
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K09958, KAKENHI-PROJECT-21K09817, KAKENHI-PROJECT-20K18512, KAKENHI-PROJECT-20K18513, KAKENHI-PROJECT-21K16972, KAKENHI-PROJECT-22K21041, KAKENHI-PROJECT-20H03865, KAKENHI-PROJECT-21K21017
[Journal Article] XAF1 overexpression exacerbates diabetes by promoting pancreatic β-cell apoptosis.2022
- Author(s)
  Nishimura Y, Iwashita M, Hayashi M, Shinjo T, Watanabe Y, Zeze T, Yamashita A, Fukuda T, Sanui T, Sano T, Asano T, Nishimura F.
- Journal Title
  
  Acta Diabetol
  
  Volume: 59 Issue: 10 Pages: 1275-1286
- DOI
  10.1007/s00592-022-01930-y
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K09958, KAKENHI-PROJECT-21K09897, KAKENHI-PROJECT-20K18512, KAKENHI-PROJECT-20K18513, KAKENHI-PROJECT-20H03732, KAKENHI-PROJECT-21K19380
[Journal Article] Endothelial cells induced progenitors into brown fat to reduce atherosclerosis2022
- Author(s)
  Park K, Li Q, Lynes MD, Yokomizo H, Maddaloni E, Shinjo T, St-Louis R, Li Q, Katagiri S, Fu J, Clermont A, Park H, Wu IH, Yu MG, Shah H, Tseng YH, King GL
- Journal Title
  
  Circulation Research
  
  Volume: 131 Issue: 2 Pages: 168-183
- DOI
  10.1161/circresaha.121.319582
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21K19590, KAKENHI-PROJECT-20K18513, KAKENHI-PROJECT-20KK0212, KAKENHI-PROJECT-20H03863
[Journal Article] Exosomes from TNF-α-treated human gingiva-derived MSCs enhance M2 macrophage polarization and inhibit periodontal bone loss2021
- Author(s)
  Nakao Yuki、Fukuda Takao、Zhang Qunzhou、Sanui Terukazu、Shinjo Takanori、Kou Xiaoxing、Chen Chider、Liu Dawei、Watanabe Yukari、Hayashi Chikako、Yamato Hiroaki、Yotsumoto Karen、Tanaka Urara、Taketomi Takaharu、Uchiumi Takeshi、Le Anh D.、Shi Songtao、Nishimura Fusanori
- Journal Title
  
  Acta Biomaterialia
  
  Volume: 122 Pages: 306-324
- DOI
  10.1016/j.actbio.2020.12.046
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K18513, KAKENHI-PROJECT-20H00530, KAKENHI-PROJECT-20H03865, KAKENHI-PROJECT-20K09958, KAKENHI-PROJECT-21K16972, KAKENHI-PROJECT-21K21089
[Journal Article] Adipose-specific C-C motif chemokine ligand (CCL) 19 overexpression drives the mice to both insulin resistance and weight gain2021
- Author(s)
  Hayashi Masato、Iwashita Misaki、Nishimura Yuki、Shinjo Takanori、Sano Tomomi、Yamashita Akiko、Fukuda Takao、Sanui Terukazu、Asano Tomoichiro、Nishimura Fusanori
- Journal Title
  
  BMJ Open Diabetes Research & Care
  
  Volume: 9 Issue: 1 Pages: e001871-e001871
- DOI
  10.1136/bmjdrc-2020-001871
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K09578, KAKENHI-PROJECT-20H03732, KAKENHI-PROJECT-20K09958, KAKENHI-PROJECT-20K18512, KAKENHI-PROJECT-20K18513, KAKENHI-PROJECT-21K21089, KAKENHI-PROJECT-20KK0212
[Journal Article] SPOCK1 induces adipose tissue maturation: New insights into the function of SPOCK1 in metabolism2020
- Author(s)
  Alshargabi Rehab、Shinjo Takanori、Iwashita Misaki、Yamashita Akiko、Sano Tomomi、Nishimura Yuki、Hayashi Masato、Zeze Tatsuro、Fukuda Takao、Sanui Terukazu、Nishimura Fusanori
- Journal Title
  
  Biochemical and Biophysical Research Communications
  
  Volume: 533 Issue: 4 Pages: 1076-1082
- DOI
  10.1016/j.bbrc.2020.09.129
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K09578, KAKENHI-PROJECT-20K09958, KAKENHI-PROJECT-19K22721, KAKENHI-PROJECT-20K18512, KAKENHI-PROJECT-20K18513, KAKENHI-PROJECT-18K17071
[Journal Article] Amelogenin Downregulates Interferon Gamma-Induced Major Histocompatibility Complex Class II Expression Through Suppression of Euchromatin Formation in the Class II Transactivator Promoter IV Region in Macrophages2020
- Author(s)
  Yotsumoto K, Sanui T, Tanaka U, Yamato H, Alshargabi R, Shinjo T, Nakao Y, Watanabe Y, Hayashi C, Taketomi T, Fukuda T, Nishimura F.
- Journal Title
  
  Frontiers in Immunology
  
  Volume: 11 Pages: 709-709
- DOI
  10.3389/fimmu.2020.00709
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K11986, KAKENHI-PROJECT-20K09958, KAKENHI-PROJECT-20K18513, KAKENHI-PROJECT-18K17052
[Journal Article] Anti-inflammatory Effects of miRNA-146a Induced in Adipose and Periodontal Tissues2020
- Author(s)
  Taiki Sanada, Tomomi Sano, Yusuke Sotomaru, Rehab Alshargabi, Yosuke Yamawaki, Akiko Yamashita, Hiroaki Matsunaga, Misaki Iwashita, Takanori Shinjo, Takashi Kanematsu, Tomoichiro Asano, Fusanori Nishimura
- Journal Title
  
  Biochem Biophys Rep.
  
  Volume: Jul Pages: 100757-100757
- DOI
  10.1016/j.bbrep.2020.100757
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K17071, KAKENHI-PROJECT-17K11670, KAKENHI-PROJECT-20K18512, KAKENHI-PROJECT-20K18513, KAKENHI-PROJECT-20H03732, KAKENHI-PROJECT-19H01056
[Journal Article] SPOCK1 is a novel inducer of epithelial to mesenchymal transition in drug-induced gingival overgrowth2020
- Author(s)
  Alshargabi Rehab、Sano Tomomi、Yamashita Akiko、Takano Aiko、Sanada Taiki、Iwashita Misaki、Shinjo Takanori、Fukuda Takao、Sanui Terukazu、Kishida Shosei、Nishimura Fusanori
- Journal Title
  
  Scientific Reports
  
  Volume: 10 Issue: 1 Pages: 9785-9785
- DOI
  10.1038/s41598-020-66660-z
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K09578, KAKENHI-PROJECT-20K09958, KAKENHI-PROJECT-19K22721, KAKENHI-PROJECT-20K18512, KAKENHI-PROJECT-20K18513, KAKENHI-PROJECT-18K17071
[Presentation] miR-1260b promotes M2 macrophage polarization by targeting NFAT5 and NLRP32024
- Author(s)
  Chikako Hayashi, Masaaki Toyoda, Kentaro Kawakami, Yuki Nakao, Miyu Shida, Takanori Shinjo, Terukazu Sanui, Takao Fukuda, Fusanori Nishimura
- Organizer
  2024 IADR/AADOCR/CADR General Session & Exhibition
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20H03865
[Presentation] 糖尿病関連歯周炎の新たな病態基盤～インスリン抵抗性の観点から2023
- Author(s)
  新城尊徳
- Organizer
  第38回日本糖尿病合併症学会シンポジウム6.歯周病を取り巻く最新の話題と医科歯科連携
- Invited
- Data Source
  KAKENHI-PROJECT-20K18513
[Presentation] 実験的歯周炎によって2型糖尿病モデルKK-Ayマウスにおける腎症は増悪する2023
- Author(s)
  新城尊徳, 佐藤晃平, 横溝久, 瀬々起朗, 今川澪, 岩下未咲, 山下明子, 西村英紀
- Organizer
  第66回日本糖尿病学会年次学術集会
- Data Source
  KAKENHI-PROJECT-20K18513
[Presentation] An emerging mechanism in diabetes-related periodontitis: the pathogenic role of insulin resistance in periodontal tissue2023
- Author(s)
  新城尊徳
- Organizer
  第71回国際歯科研究学会日本部会(JADR)総会・学術大会 Rising Scientist Session
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-23K09170
[Presentation] 歯周病による糖尿病性腎症の増悪に関する新たな分子メカニズム2023
- Author(s)
  新城尊徳, 佐藤晃平, 瀬々起朗, Ahmed Al-kafee, 大塚穂佳, 岩下未咲, 西村英紀
- Organizer
  第14回日本腎臓リハビリテーション学会学術集会ジョイントシンポジウム14 多職種コラボレーションで支える腎疾患患者の健口とは
- Invited
- Data Source
  KAKENHI-PROJECT-23K09170
[Presentation] 実験的歯周炎によって2型糖尿病モデルKK-Ayマウスにおける腎症は増悪する2023
- Author(s)
  新城尊徳, 佐藤晃平, 横溝久, 瀬々起朗, 今川澪, 岩下未咲, 山下明子, 西村英紀
- Organizer
  第66回日本糖尿病学会年次学術集会
- Data Source
  KAKENHI-PROJECT-23K09170
[Presentation] セッション3 食事と口腔衛生から考える糖尿病「歯周病と糖尿病の相互関係」2023
- Author(s)
  新城尊徳
- Organizer
  第6回日本抗加齢医学会九州地方会学術総会
- Invited
- Data Source
  KAKENHI-PROJECT-23K09170
[Presentation] An emerging mechanism in diabetes-related periodontitis: the pathogenic role of insulin resistance in periodontal tissue2023
- Author(s)
  新城尊徳
- Organizer
  第71回国際歯科研究学会日本部会(JADR)総会・学術大会 Rising Scientist Session
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K18513
[Presentation] 糖尿病関連歯周炎の新たな病態基盤～インスリン抵抗性の観点から2023
- Author(s)
  新城尊徳
- Organizer
  第38回日本糖尿病合併症学会シンポジウム6.歯周病を取り巻く最新の話題と医科歯科連携
- Invited
- Data Source
  KAKENHI-PROJECT-23K09170
[Presentation] 歯周炎による糖尿病性腎症増悪メカニズムの解明2022
- Author(s)
  新城尊徳、佐藤晃平、西村英紀
- Organizer
  日本歯科医学会第37回「歯科医学を中心とした総合的な研究を推進する集い」
- Data Source
  KAKENHI-PROJECT-20K18513
[Presentation] 九大歯学優秀研究者賞受賞講演 Regeneration of glomerular metabolism and function by podocyte pyruvate kinase M2 in diabetic nephropathy.2022
- Author(s)
  新城尊徳
- Organizer
  2022年度KOB・OBT・DDR合同国際シンポジウム
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K18513
[Presentation] Insulin Resistance and Obesity-Related Periodontitis: a Novel Molecular Basis and Potential Therapeutic Targets.2022
- Author(s)
  Takanori Shinjo
- Organizer
  2022 IADR/APR General Session & Exhibition PRG Symposium
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K18513
[Presentation] Podocyte Targeted Pyruvate Kinase M2 (PKM2) Activation Normalized Glomerular VEGF Expression, Mitochondrial Function, Fuel Metabolism, and Diabetic Nephropathy2022
- Author(s)
  Fu J, Shinjo T, Li Q, Park K, Yu MG, Yokomizo H, Huang Q, Wu IH, King GL
- Organizer
  82nd American Diabetes Association Scientific Sessions
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K18513
[Presentation] miR-1260b inhibits periodontal bone loss by targeting ATF6β2022
- Author(s)
  Hayashi C, Kawakami K, Toyoda M, Watanabe Y, Nakao Y, Yotsumoto K, Yamato H, Shinjo T, Sanui T, Fukuda T, Nishimura F.
- Organizer
  The 108th Annual Meeting of the American Academy of Periodontology
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20H03865
[Presentation] ヒト歯髄細胞由来マイクロベジクル含有PKRを標的とした歯髄鎮静薬および歯内・歯周病変モデルの作成に向けて2022
- Author(s)
  川上賢太郎、渡邊ゆかり、林千華子、豊田真顕、新城尊徳、讃井彰一、福田隆男、西村英紀
- Organizer
  第156回日本歯科保存学会2022年度春季学術大会
- Data Source
  KAKENHI-PROJECT-20H03865
[Presentation] Endothelial insulin resistance contributes to the pathogenesis of diabetes-related periodontitis2022
- Author(s)
  Tatsuro Zeze, Takanori Shinjo, Kohei Sato, Mio Imagawa, Yuki Nishimura, Misaki Iwashita, Akiko Yamashita, Takao Fukuda, Terukazu Sanui, Fusanori Nishimura
- Organizer
  2022 IADR/APR General Session & Exhibition
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K18513
[Presentation] SPOCK1はシクロスポリンによる薬剤性歯肉増殖症において歯周炎症を介した歯肉肥厚と歯槽骨吸収を増大する2022
- Author(s)
  今川澪、新城尊徳、山下明子、佐藤晃平、瀬々起朗、西村優輝、川上賢太郎、岩下未咲、西村英紀
- Organizer
  第65回秋季日本歯周病学会学術大会
- Data Source
  KAKENHI-PROJECT-20K18513
[Presentation] 糖尿病性腎症モデルマウスを用いた歯周病による腎症増悪機構の解明2022
- Author(s)
  新城尊徳、佐藤晃平、瀬々起朗、西村英紀
- Organizer
  第76回日本口腔科学会学術集会シンポジウム3「Periodontal MedicineのSDGsと未来」
- Invited
- Data Source
  KAKENHI-PROJECT-20K18513
[Presentation] ヒト歯髄細胞由来マイクロベジクル含有PKRを標的とした歯髄鎮静薬および歯内・歯周病変モデルの作成に向けて2022
- Author(s)
  川上賢太郎、渡邊ゆかり、林千華子、豊田真顕、新城尊徳、讃井彰一、福田隆男、西村英紀　ヒ川上賢太郎、渡邊ゆかり、林千華子、豊田真顕、新城尊徳、讃井彰一、福田隆男、西村英紀
- Organizer
  第157回日本歯科保存学会2022年度秋季学術大会
- Data Source
  KAKENHI-PROJECT-20H03865
[Presentation] 糖尿病性腎症モデルマウスを用いた歯周病による腎症増悪機序の解明2022
- Author(s)
  新城尊徳、佐藤晃平、瀬々起朗、西村英紀
- Organizer
  第７６回日本口腔科学会学術集会シンポジウム「Periodontal Medicineの未来とSDGs」
- Invited
- Data Source
  KAKENHI-PROJECT-20K18513
[Presentation] 歯肉幹細胞由来エクソソーム内包miR-1260bによる小胞体ストレス応答制御を介した歯周炎骨吸収抑制効果2022
- Author(s)
  林千華子、福田隆男、渡邊ゆかり、川上賢太郎、豊田真顕、中尾雄紀、四本かれん、大和寛明、新城尊徳、讃井彰一、西村英紀
- Organizer
  第65回春季日本歯周病学会学術大会
- Data Source
  KAKENHI-PROJECT-20H03865
[Presentation] 歯周炎による糖尿病性腎症増悪メカニズムの解明2022
- Author(s)
  新城尊徳、佐藤晃平、西村英紀
- Organizer
  第３７回「歯科医学を中心とした総合的な研究を推進する集い」
- Data Source
  KAKENHI-PROJECT-20K18513
[Presentation] TNF-α/IFN-α共刺激した歯肉幹細胞由来エクソソームはCD73とCD5Lを介して抗炎症性M2マクロファージを誘導する2022
- Author(s)
  渡邊ゆかり、林千華子、川上賢太郎、豊田真顕、中尾雄紀、大和寛明、四本かれん、新城尊徳、岩下未咲、讃井彰一、福田隆男、西村英紀
- Organizer
  第156回日本歯科保存学会2022年度春季学術大会
- Data Source
  KAKENHI-PROJECT-20H03865
[Presentation] 実験的歯周炎により2型糖尿病モデルKK-Ayマウスの糖尿病性腎臓病は増悪する.2021
- Author(s)
  佐藤晃平、新城尊徳、西村優輝、瀬々起朗、今川澪、岩下未咲、山下明子、西村英紀.
- Organizer
  第64回秋季日本歯周病学会学術大会
- Data Source
  KAKENHI-PROJECT-20K18513
[Presentation] 歯肉幹細胞由来エクソソーム内包miR-1260bによる小胞体ストレス応答制御を介した抗炎症作用.2021
- Author(s)
  林千華子、福田隆男、渡邊ゆかり、川上賢太郎、豊田真顕、中尾雄紀、四本かれん、大和寛明、新城尊徳、讃井彰一、西村英紀.
- Organizer
  第64回春季日本歯周病学会学術大会
- Data Source
  KAKENHI-PROJECT-20K18513
[Presentation] 歯肉幹細胞由来エクソソーム内包miR-1260bによる小胞体ストレス応答制御を介した歯槽骨吸収抑制作用.2021
- Author(s)
  林千華子, 福田隆男, 渡邊ゆかり, 川上賢太郎, 豊田真顕, 中尾雄紀, 四本かれん，大和寛明，新城尊徳，讃井彰一，西村英紀.
- Organizer
  2021年度日本歯科保存学会秋季学術大会(第155回)
- Data Source
  KAKENHI-PROJECT-20K18513
[Presentation] SPOCK1は歯周炎における歯槽骨吸収と歯肉肥厚に関与する.2021
- Author(s)
  今川澪、新城尊徳、山下明子、西村優輝、瀬々起朗、佐藤晃平、岩下未咲、西村英紀.
- Organizer
  2021年度日本歯科保存学会秋季学術大会(第155回)
- Data Source
  KAKENHI-PROJECT-20K18513
[Presentation] 膵β細胞Xaf1が膵島機能および糖尿病発症に及ぼす影響.2021
- Author(s)
  西村優輝、岩下未咲、林大翔、新城尊徳、瀬々起朗、佐野朋美、山下明子、西村英紀.
- Organizer
  2021年度日本歯科保存学会春季学術大会(第154回)
- Data Source
  KAKENHI-PROJECT-20K18513
[Presentation] Insulin Resistance in Gingival Fibroblasts Aggravates Experimental Periodontitis in Mice.2021
- Author(s)
  Shinjo T, Van Dyke TE, Hasturk H, Nishimura F, King GL.
- Organizer
  99th General Session and Exhibition of the IADR.
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K18513
[Presentation] 歯肉幹細胞由来エクソーム内包miR-1260bによる小胞体ストレス応答制御を介した歯槽骨吸収抑制作用2021
- Author(s)
  林千華子、福田隆男、渡邊ゆかり、川上賢太郎、豊田真顕、中尾雄紀、四本かれん、大和寛明、新城尊徳、讃井彰一、西村英紀
- Organizer
  第155回日本歯科保存学会2020年度秋季学術大会（WEB開催）
- Data Source
  KAKENHI-PROJECT-20H03865
[Presentation] 歯周病と糖尿病を関連付ける新たなキーファクター「インスリン作用」～ボストンでの3年間の留学生活.2021
- Author(s)
  新城尊徳
- Organizer
  第64回春季歯周病学会学術大会第54回若手研究者の集い
- Invited
- Data Source
  KAKENHI-PROJECT-20K18513
[Presentation] 歯肉幹細胞由来エクソソーム内包miR-1260bによる小胞体ストレス応答制御を介した抗炎症作用2021
- Author(s)
  林千華子、福田隆男、渡邊ゆかり、川上賢太郎、豊田真顕、中尾雄紀、四本かれん、大和寛明、新城尊徳、讃井彰一、西村英紀
- Organizer
  第64回春季日本歯周病学会学術大会（WEB開催）
- Data Source
  KAKENHI-PROJECT-20H03865
[Presentation] Identification of microRNA regulating NF-κB pathway in macrophage.2021
- Author(s)
  李栄智、佐野朋美、新城尊徳、岩下未咲、山下明子、福田隆男、西村英紀.
- Organizer
  第64回春季日本歯周病学会学術大会
- Data Source
  KAKENHI-PROJECT-20K18513
[Presentation] Exosomal miR-1260b derived from TNF-α-treated hGMSCs inhibits periodontal bone loss by targeting ATF6β-mediated regulation of ER stress.2021
- Author(s)
  Chikako Hayashi, Takao Fukuda, Yukari Watanabe, Kentaro Kawakami, Masaaki Toyoda, Yuki Nakao, Karen Yotsumoto, Hiroaki Yamato, Takanori Shinjo, Terukazu Sanui, Fusanori Nishimura
- Organizer
  The 69th Annual Meeting of Japanese Association for Dental Research (Hybrid Meeting)
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20H03865
[Presentation] 血管内皮細胞におけるインスリン抵抗性は炎症誘導性VCAM-1発現制御が破綻することで歯周炎増悪に寄与する.2021
- Author(s)
  瀬々起朗、新城尊徳、西村優輝、佐藤晃平、今川澪、岩下未咲、山下明子、西村英紀
- Organizer
  第64回秋季日本歯周病学会学術大会
- Data Source
  KAKENHI-PROJECT-20K18513
[Presentation] Exosomal miR-1260b derived from TNF-α-treated hGMSCs inhibits periodontal bone loss by targeting ATF6β-mediated regulation of ER stress.2021
- Author(s)
  Chikako Hayashi, Takao Fukuda, Yukari Watanabe, Kentaro Kawakami, Masaaki Toyoda, Yuki Nakao, Karen Yotsumoto, Hiroaki Yamato, Takanori Shinjo, Terukazu Sanui, Fusanori Nishimura
- Organizer
  Kyudai Oral Bioscience & OBT Research Center 5th Joint International Symposium
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20H03865
[Presentation] Pyruvate Kinase M2 (PKM2) Enzymatic Activity Is Necessary to Improve Podocyte Mitochondrial Function and Glomerular Fuel Metabolism and Diabetic Nephropathy.2021
- Author(s)
  Fu J, Shinjo T, St-Louis R, Li Q, Park K, Yokomizo H, Yu MG, Shah H, Wu IH, King GL.
- Organizer
  81th American Diabetes Association Scientific Sessions,
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K18513
[Presentation] Activation of Mitochondrial Activities by Pyruvate Kinase M2 (PKM2) in Podocytes Improved Glomerular Metabolism and Diabetic Nephropathy2020
- Author(s)
  Fu J, Shinjo T, St-Louis R, Li Q, Park K, Yokomizo H, Zaitsu Y, Yu MG, Wu IH, Shah H, King GL
- Organizer
  80th American Diabetes Association Scientific Sessions
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K18513
[Presentation] White and Brown Rice Supplementation Changes High-Fat Diet induced Dysbiosis of Gut Microbiome and Improves Energy and Glucose Metabolism.2020
- Author(s)
  Yokomizo H, Ishikado A, Shinjo T, Park K, Maeda Y, Li Q, Wu IH, Matsumoto M, Devkota S, Kostic A, King GL
- Organizer
  80th American Diabetes Association Scientific Sessions
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K18513
[Presentation] Insulin resistance in gingival fibroblasts exacerbates experimental periodontitis in mice.2020
- Author(s)
  Shinjo T, Van Dyke TE, Hasturk H, King GL, Nishimura F.
- Organizer
  第106回アメリカ歯周病学会共済日本歯周病学会・日本臨床歯周病学会2020年大会
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K18513
[Presentation] 歯肉におけるインスリン抵抗性は歯周炎を増悪する2020
- Author(s)
  新城尊徳、西村英紀
- Organizer
  第35回日本糖尿病合併症学会
- Data Source
  KAKENHI-PROJECT-20K18513
[Presentation] 長期生存1型糖尿病患者群における歯周病重症度と糖尿病合併症との相関2020
- Author(s)
  新城尊徳、西村英紀
- Organizer
  第63回春季日本歯周病学会学術大会
- Data Source
  KAKENHI-PROJECT-20K18513
[Presentation] IGF-1 Receptors, Not Insulin Receptors, on Mesangial Cells Are Accelerating Mesangial Expansion and Albuminuria in Streptozotocin-Induced Diabetic Mice2020
- Author(s)
  Ishikado A, Shinjo T, Yokomizo H, Maeda Y, Park K, Qi W, St-Louis R, Li Q, King GL
- Organizer
  80th American Diabetes Association Scientific Sessions
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K18513
[Presentation] 歯肉幹細胞由来エクソソームは、miR-1260bによるRANKL阻害により歯槽骨吸収を抑制する2020
- Author(s)
  中尾雄紀、福田隆男、渡邊ゆかり、林千華子、川上賢太郎、豊田真顕、四本かれん、大和寛明、新城尊徳、田中麗、讃井彰一、西村英紀
- Organizer
  第153回日本歯科保存学会2020年度秋季学術大会
- Data Source
  KAKENHI-PROJECT-20H03865
[Presentation] Reversal of Diabetic Nephropathy in T2D db/db Mouse Model by Systemic Pyruvate Kinase M2 (PKM2) Activation2020
- Author(s)
  St-Louis R, Fu J, Park K, Shinjo T, Ludeke J, Yokomizo H, Li Q, Wolfson E, King GL
- Organizer
  80th American Diabetes Association Scientific Sessions
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K18513
[Presentation] DPP4阻害薬anagliptinは、活性化マクロファージおよびマクロファージ共培養下脂肪細胞の炎症反応を抑制する2014
- Author(s)
  新城尊徳、岩下未咲、中津祐介、迫田秀之、藤城緑、櫛山暁史、鎌田英明、西村英紀、浅野知一郎
- Organizer
  日本糖尿病学会
- Place of Presentation
  大阪国際会議場
- Data Source
  KAKENHI-PROJECT-25893149
[Presentation] DPP4 Inhibitor Anagliptin Exerts Anti-inflammatory Effects on Macrophages, Adipocytes, and Mouse Liver by Suppressing LPS-induced NF-kappaB Activation2014
- Author(s)
  Takanori Shinjo, Misaki Iwashita, Hideyuki Sakoda, Fusanori Nishimura, Tomoichiro Asano
- Organizer
  American Diabetes Association
- Place of Presentation
  America, Union square
- Data Source
  KAKENHI-PROJECT-25893149
[Presentation] DPP4阻害薬Anagliptinはマクロファージ-脂肪細胞共培養系およびマウス肝臓のLPS誘導性炎症反応を抑制する
- Author(s)
  新城尊徳、岩下未咲、中津祐介、迫田秀之、藤城緑、櫛山暁史、鎌田英明、浅野知一郎、西村英紀
- Organizer
  日本糖尿病合併症学会
- Place of Presentation
  都市センターホテル
- Year and Date
  2014-10-03 – 2014-10-04
- Data Source
  KAKENHI-PROJECT-25893149
[Presentation] DPP4阻害薬anagliptinはLPS投与によるマウス肝臓・脂肪組織の炎症反応を抑制する
- Author(s)
  新城尊徳、岩下未咲、中津祐介、鎌田英明、迫田秀之、藤城緑、櫛山暁史、浅野知一郎、西村英紀
- Organizer
  日本糖尿病学会
- Place of Presentation
  下関市民会館
- Year and Date
  2015-05-21 – 2015-05-24
- Data Source
  KAKENHI-PROJECT-25893149
[Presentation] DPP4阻害薬anagliptinは、活性化マクロファージおよびマクロファージ共培養科脂肪細胞の炎症反応を抑制する
- Author(s)
  新城尊徳、岩下未咲、中津祐介、迫田秀之、藤城緑、櫛山暁史、鎌田英明、西村英紀、浅野知一郎
- Organizer
  日本糖尿病学会
- Place of Presentation
  大阪国際会議場
- Year and Date
  2014-05-22 – 2014-05-24
- Data Source
  KAKENHI-PROJECT-25893149
[Presentation] DPP4 Inhibitor Anagliptin Exerts Anti-inflammatory Effects on Macrophages, Adipocytes, Mouse Liver by Suppressing LPS-induced NF-kappaB Activation
- Author(s)
  Takanori Shinjo, Misaki Iwashita, Hideyuki Sakoda, Fusanori Nishimura, Tomoichiro Asano
- Organizer
  American Diabetes Association
- Place of Presentation
  America, San Francisco, Moscone center
- Year and Date
  2014-06-13 – 2014-06-17
- Data Source
  KAKENHI-PROJECT-25893149

1. 西村英紀 (80208222)

# of Collaborated Projects: 4 results

# of Collaborated Products: 20 results
2. Fukuda Takao (80507781)

# of Collaborated Projects: 2 results

# of Collaborated Products: 15 results
3. 横溝久 (60866747)

# of Collaborated Projects: 2 results

# of Collaborated Products: 2 results
4. 小川佳宏 (70291424)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
5. 武富孝治 (10553290)

# of Collaborated Projects: 2 results

# of Collaborated Products: 3 results
6. 讃井彰一 (70507780)

# of Collaborated Projects: 2 results

# of Collaborated Products: 15 results
7. 瀬々起朗 (60982626)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
8. 岩下未咲 (80611326)

# of Collaborated Projects: 1 results

# of Collaborated Products: 5 results
9. YAMASHITA Akiko

# of Collaborated Projects: 0 results

# of Collaborated Products: 4 results
10. KATAGIRI Sayaka

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
11. 佐野朋美

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results
12. 中尾雄紀

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Shinjo Takanori 新城 尊徳

SHINJO Takanori 新城 尊徳

Research Projects

Research Products

Co-Researchers

日本人型軽度肥満モデルの歯周病と健康寿命

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Spatial transcriptome analysis of GMSC-derived exoxme mediated peridontal tissue regneration

Principal Investigator

Project Period (FY)

Research Category

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ヒト献体サンプルを用いた解析を軸とした歯周炎ー糖尿病性腎症連関機構の解明Principal Investigator

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The molecular mechanism in the association of periodontitis and diabetic nephropathy via PGD2 signalingPrincipal Investigator

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The possible role of insulin resistance in vascular endothelial cells on exacerbation of periodontitisPrincipal Investigator

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統合オミクス解析を介した糖尿病性歯周炎の病態解明を目指す国際共同研究

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New therapeutic strategy for periodontal disease targeting exosomal miRNA derived from GMSCs.

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A investigation into anti-inflammatory effect of SK-0403 via DPP4-inhibition.Principal Investigator

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[Book] 月刊糖尿病 2022年 特集 肥満・糖尿病・歯周病 インスリン抵抗性と歯周炎～新たな分子基盤～2022

Author(s)

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Data Source

[Book] FORUM 合併症Ⅰ歯周病 歯周病と糖尿病の相互関係(2) 糖尿病プラクティス2022年9・10月号2022

Author(s)

Publisher

Data Source

[Book] FORUM 合併症Ⅰ歯周病 歯周病と糖尿病の相互関係(3) 糖尿病プラクティス2022年11・12月号2022

Author(s)

Publisher

Data Source

[Book] FORUM 合併症Ⅰ歯周病 歯周病と糖尿病の相互関係(1) 糖尿病プラクティス2022年7・8月号2022

Author(s)

Publisher

Data Source

[Book] ファーマスタイル2022年 歯周病を知る－知っておきたい歯周病の知識と全身疾患との関連2022

Author(s)

Publisher

Data Source

[Book] 糖尿病・内分泌代謝科 2022年（特集）口腔ケアと生活習慣病Up-to-date 歯周病と糖尿病及び糖尿病合併症との関連性2022

Author(s)

Publisher

Data Source

[Book] 糖尿病合併症としての歯周病 糖尿病プラクティス9・10月号2020

Author(s)

Total Pages

Shinjo Takanori 新城尊徳

SHINJO Takanori 新城尊徳

[Book] 月刊糖尿病　2022年　特集肥満・糖尿病・歯周病インスリン抵抗性と歯周炎～新たな分子基盤～2022

[Book] FORUM 合併症Ⅰ歯周病歯周病と糖尿病の相互関係(2)　糖尿病プラクティス2022年9・10月号2022

[Book] FORUM 合併症Ⅰ歯周病歯周病と糖尿病の相互関係(3)　糖尿病プラクティス2022年11・12月号2022

[Book] FORUM 合併症Ⅰ歯周病歯周病と糖尿病の相互関係(1)　糖尿病プラクティス2022年7・8月号2022

[Book] ファーマスタイル2022年　歯周病を知る－知っておきたい歯周病の知識と全身疾患との関連2022

[Book] 糖尿病・内分泌代謝科　2022年（特集）口腔ケアと生活習慣病Up-to-date 歯周病と糖尿病及び糖尿病合併症との関連性2022

[Book] 糖尿病合併症としての歯周病　糖尿病プラクティス9・10月号2020

[Book] 第8章　糖尿病　ヒト常在菌層と生理機能・全身疾患2020