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SHINTANI YASUNORI  新谷 泰範

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SHINTANI Yasunori  新谷 泰範

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Researcher Number 20712243
Other IDs
Affiliation (Current) 2025: 国立研究開発法人国立循環器病研究センター, 研究所, 部長
Affiliation (based on the past Project Information) *help 2019 – 2025: 国立研究開発法人国立循環器病研究センター, 研究所, 部長
2017 – 2019: 大阪大学, 生命機能研究科, 准教授
2016: 大阪大学, 医学系研究科, 助教
2016: 大阪大学, 大学院医学系研究科, 助教
2015: 大阪大学, 医学(系)研究科(研究院), 助教
Review Section/Research Field
Principal Investigator
Basic Section 53020:Cardiology-related / Medium-sized Section 53:Organ-based internal medicine and related fields / General medical chemistry
Except Principal Investigator
Cardiovascular medicine / Basic Section 55030:Cardiovascular surgery-related / Basic Section 56020:Orthopedics-related / Basic Section 53020:Cardiology-related
Keywords
Principal Investigator
介在板 / メカノストレス / 微小管 / AMPK / 空間トランスクリプトーム解析 / ミトコンドリア心筋症 / ミトコンドリア病 / 心筋内炎症 / 心臓介在板 / 介在版 … More
Except Principal Investigator
… More 心不全 / 空間トランスクリプトーム解析 / 先天性心疾患 / 総肺静脈還流異常症 / 肺静脈狭窄 / 封入体の形成 / 核の中心化 / 空胞 / 神経筋接合部 / フレイル / サルコペニア / トランスレーショナル研究 / cardiac MLCK / キナーゼ活性化機構 / cMLCK / サルコメア / ミオシン調節軽鎖キナーゼ / 細胞遊走 / Pdlim5 / AMPキナーゼ / cell migration / AMPK / cell migration / PDLIM5 / AMPK Less
  • Research Projects

    (10 results)
  • Research Products

    (15 results)
  • Co-Researchers

    (33 People)
  •  Elucidation of the pathogenesis of pulmonary vein stenosis in total anomalous pulmonary venous return using spatial transcriptome analysis

    • Principal Investigator
      盤井 成光
    • Project Period (FY)
      2025 – 2027
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 55030:Cardiovascular surgery-related
    • Research Institution
      National Cardiovascular Center Research Institute
  •  Spatially resolved transcriptomics analysis of mitochondrial cardiomyopathyPrincipal Investigator

    • Principal Investigator
      新谷 泰範
    • Project Period (FY)
      2024 – 2026
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Review Section
      Basic Section 53020:Cardiology-related
    • Research Institution
      National Cardiovascular Center Research Institute
  •  ミトコンドリア病における病態進行過程の理解と新規治療法の開発Principal Investigator

    • Principal Investigator
      新谷 泰範
    • Project Period (FY)
      2023 – 2024
    • Research Category
      Grant-in-Aid for Challenging Research (Exploratory)
    • Review Section
      Medium-sized Section 53:Organ-based internal medicine and related fields
    • Research Institution
      National Cardiovascular Center Research Institute
  •  遠隔虚血コンディショニングによる心不全発症・進展抑止効果とそのメカニズムの検討

    • Principal Investigator
      浅沼 博司
    • Project Period (FY)
      2022 – 2024
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 53020:Cardiology-related
    • Research Institution
      Meiji University of Integrative Medicine
  •  新規メカノストレス因子による筋疾患への治療介入およびQOL維持への貢献

    • Principal Investigator
      山崎 悟
    • Project Period (FY)
      2022 – 2024
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 56020:Orthopedics-related
    • Research Institution
      National Cardiovascular Center Research Institute
  •  A key intercalated disc molecule determines the prognosis of dilated cardiomyopathyPrincipal Investigator

    • Principal Investigator
      Shintani Yasunori
    • Project Period (FY)
      2021 – 2023
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Review Section
      Basic Section 53020:Cardiology-related
    • Research Institution
      National Cardiovascular Center Research Institute
  •  Elucidation of the mechanism in which mechanostress modulates cardiac microtubules dynamicsPrincipal Investigator

    • Principal Investigator
      SHINTANI YASUNORI
    • Project Period (FY)
      2018 – 2020
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 53020:Cardiology-related
    • Research Institution
      National Cardiovascular Center Research Institute
      Osaka University
  •  Analysis of the regulatory mechanism of the activity of cardiac specific myosin light chain kinase

    • Principal Investigator
      Tsukamoto Osamu
    • Project Period (FY)
      2017 – 2019
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Cardiovascular medicine
    • Research Institution
      Osaka University
  •  A novel AMPK singaling at the intercalated disc in heartPrincipal Investigator

    • Principal Investigator
      SHINTANI YASUNORI
    • Project Period (FY)
      2015 – 2017
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      General medical chemistry
    • Research Institution
      Osaka University
  •  anti-atherosclerotic and anti-cancer effects of AMPK activation

    • Principal Investigator
      Tsukamoto Osamu
    • Project Period (FY)
      2014 – 2016
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Cardiovascular medicine
    • Research Institution
      Osaka University

All 2022 2021 2020 2019 2016 2015 2013

All Journal Article Presentation

  • [Journal Article] Identifying antibiotics based on structural differences in the conserved allostery from mitochondrial heme-copper oxidases.2022

    • Author(s)
      Nishida Y, Yanagisawa S, Morita R, Shigematsu H, Shinzawa-Itoh K, Yuki H, Ogasawara S, et al
    • Journal Title

      Nat Commun.

      Volume: 13 Issue: 1 Pages: 7591-7591

    • DOI

      10.1038/s41467-022-34771-y

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-22K06130, KAKENHI-PROJECT-22K09391, KAKENHI-PROJECT-21H02064, KAKENHI-PROJECT-20K03794, KAKENHI-PROJECT-20K07338, KAKENHI-PROJECT-21K15443, KAKENHI-PROJECT-21K15776, KAKENHI-PLANNED-18H05425, KAKENHI-PLANNED-19H05761, KAKENHI-PLANNED-19H05784, KAKENHI-PUBLICLY-22H04760, KAKENHI-PUBLICLY-22H04800, KAKENHI-PROJECT-21H02914
  • [Journal Article] The CR9 element is a novel mechanical load‐responsive enhancer that regulates natriuretic peptide genes expression2021

    • Author(s)
      Miyashita Y, Tsukamoto O, Matsuoka K, Kamikubo K, Kuramoto Y, Fu HY, Tsubota T, Hasuike H, Takayama T, Ito H, Hitsumoto T, Okamoto C, Kioka H, Oya R, Shinomiya H, Hakui H, Shintani Y, Kato H, Kitakaze M, Sakata Y, Asano Y, Takashima S
    • Journal Title

      The FASEB Journal

      Volume: 35 Issue: 4

    • DOI

      10.1096/fj.202002111rr

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-20K07338, KAKENHI-PROJECT-18K08105, KAKENHI-PROJECT-19K08581, KAKENHI-PROJECT-20K17151, KAKENHI-PROJECT-19H03652
  • [Journal Article] In vivo real‐time ATP imaging in zebrafish hearts reveals G0s2 induces ischemic tolerance2020

    • Author(s)
      Kioka Hidetaka、Kato Hisakazu、Fujita Takeshi、Asano Yoshihiro、Shintani Yasunori、Yamazaki Satoru、Tsukamoto Osamu、Imamura Hiromi、Kogo Mikihiko、Kitakaze Masafumi、Sakata Yasushi、Takashima Seiji
    • Journal Title

      The FASEB Journal

      Volume: 34 Issue: 2 Pages: 2041-2054

    • DOI

      10.1096/fj.201901686r

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19K08581, KAKENHI-PROJECT-17H03654, KAKENHI-PROJECT-17K09577, KAKENHI-PROJECT-19K09408, KAKENHI-PROJECT-19K22386, KAKENHI-PROJECT-18K08105, KAKENHI-PROJECT-19H03652, KAKENHI-PROJECT-18K19547, KAKENHI-PROJECT-17K09578
  • [Journal Article] AMPK regulates cell shape of cardiomyocytes by modulating turnover of microtubules through CLIP‐1702020

    • Author(s)
      Yashirogi Shohei、Nagao Takemasa、Nishida Yuya、Takahashi Yusuke、Qaqorh Tasneem、Yazawa Issei、Katayama Toru、Kioka Hidetaka、Matsui Tsubasa S、Saito Shigeyoshi、Masumura Yuki、Tsukamoto Osamu、Kato Hisakazu、Ueda Hiromichi、Yamaguchi Osamu、Yashiro Kenta、Yamazaki Satoru、Takashima Seiji、Shintani Yasunori
    • Journal Title

      EMBO reports

      Volume: 22 Issue: 1

    • DOI

      10.15252/embr.202050949

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-19K08581, KAKENHI-PROJECT-20K07338, KAKENHI-PROJECT-18K08105, KAKENHI-PROJECT-19K09408, KAKENHI-PROJECT-21K15443
  • [Journal Article] Endocardium differentiation through Sox17 expression in endocardium precursor cells regulates heart development in mice2019

    • Author(s)
      Saba Rie、Kitajima Keiko、Rainbow Lucille、Engert Silvia、Uemura Mami、Ishida Hidekazu、Kokkinopoulos Ioannis、Shintani Yasunori、Miyagawa Shigeru、Kanai Yoshiakira、Kanai-Azuma Masami、Koopman Peter、Meno Chikara、Kenny John、Lickert Heiko、Saga Yumiko、Suzuki Ken、Sawa Yoshiki、Yashiro Kenta
    • Journal Title

      Scientific Reports

      Volume: 9 Issue: 1 Pages: 11953-11953

    • DOI

      10.1038/s41598-019-48321-y

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-18K08105, KAKENHI-PROJECT-17H01571, KAKENHI-PROJECT-17H04228, KAKENHI-PROJECT-17K19523, KAKENHI-PROJECT-18K14583
  • [Journal Article] Higd1a improves respiratory function in the models of mitochondrial disorder2019

    • Author(s)
      Nagao Takemasa、Shintani Yasunori、Hayashi Takaharu、Kioka Hidetaka、Kato Hisakazu、Nishida Yuya、Yamazaki Satoru、Tsukamoto Osamu、Yashirogi Shohei、Yazawa Issei、Asano Yoshihiro、Shinzawa‐Itoh Kyoko、Imamura Hiromi、Suzuki Takeo、Suzuki Tsutomu、Goto Yu‐ichi、Takashima Seiji
    • Journal Title

      The FASEB Journal

      Volume: 34 Issue: 1 Pages: 1859-1871

    • DOI

      10.1096/fj.201800389r

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-18K08105, KAKENHI-PROJECT-19K08581, KAKENHI-PROJECT-19K22246, KAKENHI-PROJECT-17H03646, KAKENHI-PROJECT-17H03654, KAKENHI-PROJECT-18H02094, KAKENHI-PROJECT-17K09577, KAKENHI-PROJECT-19K09408, KAKENHI-PROJECT-18H05272, KAKENHI-PROJECT-19K22386, KAKENHI-PROJECT-19H03652, KAKENHI-PROJECT-18K19547, KAKENHI-PROJECT-17K09578
  • [Journal Article] A molecular triage process mediated by RING finger protein 126 and BCL2-associated athanogene 6 regulates degradation of G0/G1 switch gene 22019

    • Author(s)
      Kamikubo Kenta、Kato Hisakazu、Kioka Hidetaka、Yamazaki Satoru、Tsukamoto Osamu、Nishida Yuya、Asano Yoshihiro、Imamura Hiromi、Kawahara Hiroyuki、Shintani Yasunori、Takashima Seiji
    • Journal Title

      Journal of Biological Chemistry

      Volume: 294 Issue: 40 Pages: 14562-14573

    • DOI

      10.1074/jbc.ra119.008544

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-18K08105, KAKENHI-PROJECT-19K08581, KAKENHI-PROJECT-19K09408, KAKENHI-PUBLICLY-19H05293, KAKENHI-PROJECT-17H03654, KAKENHI-PROJECT-17H03657, KAKENHI-PROJECT-17K09577, KAKENHI-PROJECT-19K22386, KAKENHI-PROJECT-19H03652, KAKENHI-PROJECT-18K19547, KAKENHI-PROJECT-17K09578
  • [Journal Article] Cell Size Critically Determines Initial Retention of Bone Marrow Mononuclear Cells in the Heart after Intracoronary Injection: Evidence from a Rat Model.2016

    • Author(s)
      Campbell NG, Kaneko M, Shintani Y, Narita T, Sawhney V, Coppen SR, Yashiro K, Mathur A, Suzuki K.
    • Journal Title

      PLoS One.

      Volume: 11 Issue: 7 Pages: e0158232-e0158232

    • DOI

      10.1371/journal.pone.0158232

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-15K08271
  • [Journal Article] Alternatively activated macrophages determine repair of the infarcted adult murine heart.2016

    • Author(s)
      Shiraishi M, Shintani Y, Shintani Y, Ishida H, Saba R, Yamaguchi A, Adachi H, Yashiro K, Suzuki K.
    • Journal Title

      J Clin Invest.

      Volume: 126 Issue: 6 Pages: 2151-66

    • DOI

      10.1172/jci85782

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-15K08271
  • [Journal Article] Btg2 is a Negative Regulator of Cardiomyocyte Hypertrophy through a Decrease in Cytosolic RNA.2016

    • Author(s)
      Masumura Y, Higo S, Asano Y, Kato H, Yan Y, Ishino S, Tsukamoto O, Kioka H, Hayashi T, Shintani Y, Yamazaki S, Minamino T, Kitakaze M, Komuro I, Takashima S, Sakata Y.
    • Journal Title

      Sci Rep.

      Volume: 6 Issue: 1 Pages: 28592-28592

    • DOI

      10.1038/srep28592

    • Peer Reviewed / Acknowledgement Compliant / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-15H04820, KAKENHI-PROJECT-15H04821, KAKENHI-PROJECT-26461108, KAKENHI-PROJECT-15K19378, KAKENHI-PROJECT-15K08271, KAKENHI-PROJECT-15K09111, KAKENHI-PROJECT-15K09139, KAKENHI-PROJECT-16K09500, KAKENHI-PROJECT-16K09501
  • [Journal Article] Higdla is a oositive regulaator of cytochrome c oxidase2015

    • Author(s)
      T. Hayashi, Y. Asano, Y. Shintani, H. Aoyama, H. Kioka, O. Tsukamoto, M. Hikita, K. Shinzawa-Itoh, K. Takajuji, S. Higo, H. Kato, S. Yamazaki, K. Matsuoka, A. Nakano, H. Asanuma, M. Asakura, T. Minamino, Y. Goto, T. Ogura, M. Kitakaze, I. Komuro, Y. Sakata, T. Tsukihara, S. Yoshikawa, S. Takashima
    • Journal Title

      Proc. Nat. Acad. Sci. U.S.A.

      Volume: 112 Issue: 5 Pages: 1553-1558

    • DOI

      10.1073/pnas.1419767112

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-24350086, KAKENHI-PROJECT-24390203, KAKENHI-PROJECT-24591096, KAKENHI-PROJECT-24591097, KAKENHI-PUBLICLY-25109540, KAKENHI-PROJECT-25860599, KAKENHI-PUBLICLY-26104532, KAKENHI-PROJECT-26291033, KAKENHI-PROJECT-26461134, KAKENHI-PROJECT-26670402, KAKENHI-PROJECT-26860558, KAKENHI-PROJECT-26860559, KAKENHI-PROJECT-15K09111, KAKENHI-PROJECT-26461108, KAKENHI-PROJECT-26253049, KAKENHI-PROJECT-25461119
  • [Journal Article] Augmented AMPK activity inhibits cell migration by phosphorylating the novel substrate Pdlim5.2015

    • Author(s)
      Yan Y, Tsukamoto O, Nakano A, Kato H, Kioka H, Ito N, Higo S, Yamazaki S, Shintani Y, Matsuoka K, Liao Y, Asanuma H, Asakura M, Takafuji K, Minamino T, Asano Y, Kitakaze M, Takashima S.
    • Journal Title

      Nat Commun.

      Volume: 6 Issue: 1 Pages: 6137-6137

    • DOI

      10.1038/ncomms7137

    • Peer Reviewed / Acknowledgement Compliant / Open Access
    • Data Source
      KAKENHI-PROJECT-24390203, KAKENHI-PROJECT-24591096, KAKENHI-PROJECT-24591097, KAKENHI-PROJECT-25860599, KAKENHI-PROJECT-26860558, KAKENHI-PROJECT-26860559, KAKENHI-PROJECT-15K09111, KAKENHI-PROJECT-26461108, KAKENHI-PROJECT-25461119
  • [Journal Article] Evaluation of intra-mitochondrial ATP levels identifies G0/G1 switch gene 2 as a positive regulator of oxidative phosphorylation2013

    • Author(s)
      Kioka H, Kato H, Fujikawa M, Tsukamoto O, Suzuki T, Imamura H, Nakano A, Higo S, Yamazaki S, Matsuzaki T, Tkafuji K, Asanuma H, Asakura M, Minamino T, Shintani Y, Yoshida M, Noji H, Kitakaze M, Komuro I, Asano Y and Takashima S
    • Journal Title

      PNAS

      Volume: 111 Issue: 1 Pages: 273-278

    • DOI

      10.1073/pnas.1318547111

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PLANNED-23115002, KAKENHI-PROJECT-23227006, KAKENHI-PROJECT-23591093, KAKENHI-PROJECT-24390203, KAKENHI-PROJECT-24570149, KAKENHI-PROJECT-24591096, KAKENHI-PROJECT-24591097, KAKENHI-PROJECT-24657101, KAKENHI-PROJECT-24790757, KAKENHI-PROJECT-24790917, KAKENHI-PROJECT-25251016, KAKENHI-PROJECT-25253047, KAKENHI-PROJECT-25461119, KAKENHI-PROJECT-25860599, KAKENHI-PROJECT-26461108
  • [Presentation] 心筋特異的な膜タンパク質の同定2015

    • Author(s)
      矢澤一生,矢白木翔平,新谷泰範,高島成二
    • Organizer
      第62回 日本生化学会 近畿支部例会
    • Place of Presentation
      立命館大学びわこ・くさつキャンパス(滋賀県草津市)
    • Year and Date
      2015-05-16
    • Data Source
      KAKENHI-PROJECT-15K08271
  • [Presentation] 心筋細胞におけるAMPKによる微小管の動的不安定性制御の解析2015

    • Author(s)
      矢白木翔平,新谷泰範,高島成二
    • Organizer
      第38回日本分子生物学会年会
    • Place of Presentation
      神戸国際展示場
    • Year and Date
      2015-12-01
    • Data Source
      KAKENHI-PROJECT-15K08271
  • 1.  TSUKAMOTO Osamu (80589151)
    # of Collaborated Projects: 4 results
    # of Collaborated Products: 3 results
  • 2.  高橋 佑典 (70880912)
    # of Collaborated Projects: 3 results
    # of Collaborated Products: 0 results
  • 3.  朝野 仁裕 (60527670)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 0 results
  • 4.  山崎 悟 (70348796)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 1 results
  • 5.  MORISHIMA Keisuke (60359114)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 6.  YALIKUN Yaxiaer (30735064)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 7.  YAMAGUCHI Osamu (90467580)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 1 results
  • 8.  KATO Hisakazu (30589312)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 1 results
  • 9.  HIGO Shuichiro (00604034)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 10.  西田 優也 (10793440)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 11.  渡邉 琢也 (20627509)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 12.  大郷 恵子 (30601827)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 13.  白井 学 (70294121)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 14.  浅沼 博司 (20416217)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 1 results
  • 15.  伊藤 慎 (20796560)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 1 results
  • 16.  武田 充人 (00374413)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 17.  池田 善彦 (30393242)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 18.  盤井 成光 (50974523)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 19.  畠山 金太 (60325735)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 20.  富永 佑児 (80838558)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 21.  YASHIROGI Shohei
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 2 results
  • 22.  YAZAWA Issei
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 1 results
  • 23.  Yan Yi
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 24.  TAKASHIMA Seiji
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 25.  ASANO Yoshihiro
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 26.  ASAKURA Masanori
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 27.  NAKANO Astushi
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 28.  MIN Kyung-Duk
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 29.  小倉 尚志
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 30.  木岡 秀隆
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 2 results
  • 31.  新沢 伊藤恭子
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 32.  野地 博行
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 33.  北風 政史
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results

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