SHINTANI YASUNORI 新谷泰範

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SHINTANI Yasunori 新谷泰範

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Researcher Number	20712243
Other IDs
Affiliation (Current)	2022: 国立研究開発法人国立循環器病研究センター, 研究所, 部長
Affiliation (based on the past Project Information) *help	2019 – 2022: 国立研究開発法人国立循環器病研究センター, 研究所, 部長 2017 – 2019: 大阪大学, 生命機能研究科, 准教授 2016: 大阪大学, 医学系研究科, 助教 2016: 大阪大学, 大学院医学系研究科, 助教 2015: 大阪大学, 医学(系)研究科(研究院), 助教
Review Section/Research Field	Principal Investigator Basic Section 53020:Cardiology-related / General medical chemistry Except Principal Investigator Cardiovascular medicine / Basic Section 53020:Cardiology-related / Basic Section 56020:Orthopedics-related
Keywords	Principal Investigator AMPK / 微小管 / 介在板 / メカノストレス / 介在版 / 心臓介在板 / 心筋内炎症 Except Principal Investigator 心不全 / AMPK / PDLIM5 … More / cell migration / ＡＭＰＫ / ｃｅｌｌ　ｍｉｇｒａｔｉｏｎ / AMPキナーゼ / Pdlim5 / 細胞遊走 / ミオシン調節軽鎖キナーゼ / サルコメア / ｃMLCK / キナーゼ活性化機構 / cardiac MLCK / トランスレーショナル研究 / サルコペニア / フレイル / 神経筋接合部 / 核の中心化 / 封入体の形成 Less

遠隔虚血コンディショニングによる心不全発症・進展抑止効果とそのメカニズムの検討
- Principal Investigator
  
  浅沼博司
- Project Period (FY)
  2022 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 53020:Cardiology-related
- Research Institution
  Meiji University of Integrative Medicine
新規メカノストレス因子による筋疾患への治療介入およびQOL維持への貢献
- Principal Investigator
  
  山崎悟
- Project Period (FY)
  2022 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 56020:Orthopedics-related
- Research Institution
  National Cardiovascular Center Research Institute
心筋内炎症の鍵となる介在板分子は拡張型心筋症の予後を規定するか？Principal Investigator
- Principal Investigator
  
  新谷泰範
- Project Period (FY)
  2021 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 53020:Cardiology-related
- Research Institution
  National Cardiovascular Center Research Institute
Elucidation of the mechanism in which mechanostress modulates cardiac microtubules dynamicsPrincipal Investigator
- Principal Investigator
  
  SHINTANI YASUNORI
- Project Period (FY)
  2018 – 2020
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 53020:Cardiology-related
- Research Institution
  National Cardiovascular Center Research Institute
  Osaka University
Analysis of the regulatory mechanism of the activity of cardiac specific myosin light chain kinase
- Principal Investigator
  
  Tsukamoto Osamu
- Project Period (FY)
  2017 – 2019
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Cardiovascular medicine
- Research Institution
  Osaka University
A novel AMPK singaling at the intercalated disc in heartPrincipal Investigator
- Principal Investigator
  
  SHINTANI YASUNORI
- Project Period (FY)
  2015 – 2017
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  General medical chemistry
- Research Institution
  Osaka University
anti-atherosclerotic and anti-cancer effects of AMPK activation
- Principal Investigator
  
  Tsukamoto Osamu
- Project Period (FY)
  2014 – 2016
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Cardiovascular medicine
- Research Institution
  Osaka University

All 2021 2020 2019 2016 2015 2014

All Journal Article Presentation

[Journal Article] The CR9 element is a novel mechanical load‐responsive enhancer that regulates natriuretic peptide genes expression2021
- Author(s)
  Miyashita Y, Tsukamoto O, Matsuoka K, Kamikubo K, Kuramoto Y, Fu HY, Tsubota T, Hasuike H, Takayama T, Ito H, Hitsumoto T, Okamoto C, Kioka H, Oya R, Shinomiya H, Hakui H, Shintani Y, Kato H, Kitakaze M, Sakata Y, Asano Y, Takashima S
- Journal Title
  
  The FASEB Journal
  
  Volume: 35
- DOI
  10.1096/fj.202002111rr
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K07338, KAKENHI-PROJECT-20K17151, KAKENHI-PROJECT-18K08105
[Journal Article] In vivo real‐time ATP imaging in zebrafish hearts reveals G0s2 induces ischemic tolerance2020
- Author(s)
  Kioka Hidetaka、Kato Hisakazu、Fujita Takeshi、Asano Yoshihiro、Shintani Yasunori、Yamazaki Satoru、Tsukamoto Osamu、Imamura Hiromi、Kogo Mikihiko、Kitakaze Masafumi、Sakata Yasushi、Takashima Seiji
- Journal Title
  
  The FASEB Journal
  
  Volume: 34 Pages: 2041-2054
- DOI
  10.1096/fj.201901686r
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19K08581, KAKENHI-PROJECT-17H03654, KAKENHI-PROJECT-17K09577, KAKENHI-PROJECT-19K09408, KAKENHI-PROJECT-19K22386, KAKENHI-PROJECT-18K08105
[Journal Article] Higd1a improves respiratory function in the models of mitochondrial disorder2020
- Author(s)
  Nagao Takemasa、Shintani Yasunori、Hayashi Takaharu、Kioka Hidetaka、Kato Hisakazu、Nishida Yuya、Yamazaki Satoru、Tsukamoto Osamu、Yashirogi Shohei、Yazawa Issei、Asano Yoshihiro、Shinzawa‐Itoh Kyoko、Imamura Hiromi、Suzuki Takeo、Suzuki Tsutomu、Goto Yu‐ichi、Takashima Seiji
- Journal Title
  
  FASEB J
  
  Volume: 34 Pages: 1859-1871
- DOI
  10.1096/fj.201800389r
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18K08105, KAKENHI-PROJECT-19K08581, KAKENHI-PROJECT-19K22246, KAKENHI-PROJECT-17H03646, KAKENHI-PROJECT-17H03654, KAKENHI-PROJECT-18H02094, KAKENHI-PROJECT-17K09577, KAKENHI-PROJECT-19K09408, KAKENHI-PROJECT-18H05272, KAKENHI-PROJECT-19K22386
[Journal Article] AMPK regulates cell shape of cardiomyocytes by modulating turnover of microtubules through CLIP‐1702020
- Author(s)
  Yashirogi Shohei、Nagao Takemasa、Nishida Yuya、Takahashi Yusuke、Qaqorh Tasneem、Yazawa Issei、Katayama Toru、Kioka Hidetaka、Matsui Tsubasa S、Saito Shigeyoshi、Masumura Yuki、Tsukamoto Osamu、Kato Hisakazu、Ueda Hiromichi、Yamaguchi Osamu、Yashiro Kenta、Yamazaki Satoru、Takashima Seiji、Shintani Yasunori
- Journal Title
  
  EMBO reports
  
  Volume: 22
- DOI
  10.15252/embr.202050949
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K08581, KAKENHI-PROJECT-19K09408, KAKENHI-PROJECT-20K07338, KAKENHI-PROJECT-18K08105
[Journal Article] Endocardium differentiation through Sox17 expression in endocardium precursor cells regulates heart development in mice.2019
- Author(s)
  Saba Rie、Kitajima Keiko、Rainbow Lucille、Engert Silvia、Uemura Mami、Ishida Hidekazu、Kokkinopoulos Ioannis、Shintani Yasunori、Miyagawa Shigeru、Kanai Yoshiakira、Kanai-Azuma Masami、Koopman Peter、Meno Chikara、Kenny John、Lickert Heiko、Saga Yumiko、Suzuki Ken、Sawa Yoshiki、Yashiro Kenta
- Journal Title
  
  Sci Rep.
  
  Volume: 9 Pages: 11953-11953
- DOI
  10.1038/s41598-019-48321-y
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K08105, KAKENHI-PROJECT-17H01571, KAKENHI-PROJECT-17H04228, KAKENHI-PROJECT-17K19523
[Journal Article] A molecular triage process mediated by RING finger protein 126 and BCL2-associated athanogene 6 regulates degradation of G0/G1 switch gene 2.2019
- Author(s)
  Kamikubo Kenta、Kato Hisakazu、Kioka Hidetaka、Yamazaki Satoru、Tsukamoto Osamu、Nishida Yuya、Asano Yoshihiro、Imamura Hiromi、Kawahara Hiroyuki、Shintani Yasunori、Takashima Seiji
- Journal Title
  
  J. Biol. Chem.
  
  Volume: 294 Pages: 14562-14573
- DOI
  10.1074/jbc.ra119.008544
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18K08105, KAKENHI-PROJECT-19K08581, KAKENHI-PROJECT-19K09408, KAKENHI-PUBLICLY-19H05293, KAKENHI-PROJECT-17H03654, KAKENHI-PROJECT-17H03657, KAKENHI-PROJECT-17K09577, KAKENHI-PROJECT-19K22386
[Journal Article] Cell Size Critically Determines Initial Retention of Bone Marrow Mononuclear Cells in the Heart after Intracoronary Injection: Evidence from a Rat Model.2016
- Author(s)
  Campbell NG, Kaneko M, Shintani Y, Narita T, Sawhney V, Coppen SR, Yashiro K, Mathur A, Suzuki K.
- Journal Title
  
  PLoS One.
  
  Volume: 11
- DOI
  10.1371/journal.pone.0158232
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K08271
[Journal Article] Alternatively activated macrophages determine repair of the infarcted adult murine heart.2016
- Author(s)
  Shiraishi M, Shintani Y, Shintani Y, Ishida H, Saba R, Yamaguchi A, Adachi H, Yashiro K, Suzuki K.
- Journal Title
  
  J Clin Invest.
  
  Volume: 126 Pages: 2151-66
- DOI
  10.1172/jci85782
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K08271
[Journal Article] Btg2 is a Negative Regulator of Cardiomyocyte Hypertrophy through a Decrease in Cytosolic RNA2016
- Author(s)
  Masumura Y, Higo S, Asano Y, Kato H, Yan Y, Ishino S, Tsukamoto O, Kioka H, Hayashi T, Shintani Y, Yamazaki S, Minamino T, Kitakaze M, Komuro I, Takashima S, Sakata Y.
- Journal Title
  
  Science Report
  
  Volume: 6 Pages: 28592-28592
- DOI
  10.1038/srep28592
- Peer Reviewed / Acknowledgement Compliant / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15H04820, KAKENHI-PROJECT-15H04821, KAKENHI-PROJECT-26461108, KAKENHI-PROJECT-15K19378, KAKENHI-PROJECT-15K08271, KAKENHI-PROJECT-15K09111, KAKENHI-PROJECT-15K09139, KAKENHI-PROJECT-16K09500, KAKENHI-PROJECT-16K09501
[Journal Article] Higd1a is a positive regulator of cytochrome c oxidase.2015
- Author(s)
  T. Hayashi, Y. Asano, Y. Shintani, H. Aoyama, H. Kioka, O. Tsukamoto, M. Hikita, K. Shinzawa-Itoh, K. Takajuji, S. Higo, H. Kato, S. Yamazaki, K. Matsuoka, A. Nakano, H. Asanuma, M. Asakura, T. Minamino, Y. Goto, T. Ogura, M. Kitakaze, I. Komuro, Y. Sakata, T. Tsukihara, S. Yoshikawa, S. Takashima
- Journal Title
  
  Proc Natl Acad Sci U SA
  
  Volume: 112 Pages: 1553-1553
- DOI
  10.1073/pnas.1419767112
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-24350086, KAKENHI-PROJECT-24390203, KAKENHI-PROJECT-24591096, KAKENHI-PROJECT-24591097, KAKENHI-PUBLICLY-25109540, KAKENHI-PROJECT-25860599, KAKENHI-PUBLICLY-26104532, KAKENHI-PROJECT-26291033, KAKENHI-PROJECT-26461134, KAKENHI-PROJECT-26670402, KAKENHI-PROJECT-26860558, KAKENHI-PROJECT-26860559, KAKENHI-PROJECT-15K09111, KAKENHI-PROJECT-26461108, KAKENHI-PROJECT-26253049, KAKENHI-PROJECT-25461119
[Journal Article] Augmented AMPK activity inhibits cell migration by phosphorylating the novel substrate Pdlim52015
- Author(s)
  Yan Y, Tsukamoto O, Nakano A, Kato H, Kioka H, Ito N, Higo S, Yamazaki S, Shintani Y, Matsuoka K, Liao Y, Asanuma H, Asakura M, Takafuji K, Minamino T, Asano Y, Kitakaze M, Takashima S.
- Journal Title
  
  Ｎature Ｃommunications
  
  Volume: 6 Pages: 0-0
- DOI
  10.1038/ncomms7137
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-24390203, KAKENHI-PROJECT-24591096, KAKENHI-PROJECT-24591097, KAKENHI-PROJECT-25860599, KAKENHI-PROJECT-26860558, KAKENHI-PROJECT-26860559, KAKENHI-PROJECT-15K09111, KAKENHI-PROJECT-26461108, KAKENHI-PROJECT-25461119
[Journal Article] Evaluation of intra-mitochondrial ATP levels identifies G0/G1 switch gene 2 as a positive regulator of oxidative phosphorylation.2014
- Author(s)
  Kioka H, Kato H, Fujikawa M, Tsukamoto O, Suzuki T, Imamura H, Nakano A, Higo S, Yamazaki S, Matsuzaki T, Tkafuji K, Asanuma H, Asakura M, Minamino T, Shintani Y, Yoshida M, Noji H, Kitakaze M, Komuro I, Asano Y and Takashima S
- Journal Title
  
  Proceedings of the National Academy of Sciences of the United States of America
  
  Volume: 111 Pages: 273-273
- DOI
  10.1073/pnas.1318547111
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PLANNED-23115002, KAKENHI-PROJECT-23227006, KAKENHI-PROJECT-23591093, KAKENHI-PROJECT-24390203, KAKENHI-PROJECT-24570149, KAKENHI-PROJECT-24591096, KAKENHI-PROJECT-24591097, KAKENHI-PROJECT-24657101, KAKENHI-PROJECT-24790757, KAKENHI-PROJECT-24790917, KAKENHI-PROJECT-25251016, KAKENHI-PROJECT-25253047, KAKENHI-PROJECT-25461119, KAKENHI-PROJECT-25860599, KAKENHI-PROJECT-26461108
[Presentation] 心筋特異的な膜タンパク質の同定2015
- Author(s)
  矢澤一生，矢白木翔平，新谷泰範，高島成二
- Organizer
  第62回日本生化学会近畿支部例会
- Place of Presentation
  立命館大学びわこ・くさつキャンパス（滋賀県草津市）
- Year and Date
  2015-05-16
- Data Source
  KAKENHI-PROJECT-15K08271
[Presentation] 心筋細胞におけるAMPKによる微小管の動的不安定性制御の解析2015
- Author(s)
  矢白木翔平，新谷泰範，高島成二
- Organizer
  第38回日本分子生物学会年会
- Place of Presentation
  神戸国際展示場
- Year and Date
  2015-12-01
- Data Source
  KAKENHI-PROJECT-15K08271

1. TSUKAMOTO Osamu (80589151)

# of Collaborated Projects: 4 results

# of Collaborated Products: 9 results
2. 朝野仁裕 (60527670)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
3. 山崎悟 (70348796)

# of Collaborated Projects: 2 results

# of Collaborated Products: 8 results
4. 高橋佑典 (70880912)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
5. MORISHIMA Keisuke (60359114)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
6. YALIKUN Yaxiaer (30735064)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
7. YAMAGUCHI Osamu (90467580)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
8. KATO Hisakazu (30589312)

# of Collaborated Projects: 1 results

# of Collaborated Products: 9 results
9. HIGO Shuichiro (00604034)

# of Collaborated Projects: 1 results

# of Collaborated Products: 4 results
10. 西田優也 (10793440)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
11. 渡邉琢也 (20627509)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
12. 大郷恵子 (30601827)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
13. 白井学 (70294121)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
14. 浅沼博司 (20416217)

# of Collaborated Projects: 1 results

# of Collaborated Products: 3 results
15. 伊藤慎 (20796560)

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
16. YASHIROGI Shohei

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
17. YAZAWA Issei

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
18. Yan Yi

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
19. ASAKURA Masanori

# of Collaborated Projects: 0 results

# of Collaborated Products: 3 results
20. NAKANO Astushi

# of Collaborated Projects: 0 results

# of Collaborated Products: 6 results
21. IHARA Madoka

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
22. MIN Kyung-Duk

# of Collaborated Projects: 0 results

# of Collaborated Products: 3 results
23. MINAMINO Tetsuo

# of Collaborated Projects: 0 results

# of Collaborated Products: 4 results
24. ASANO Yoshihiro

# of Collaborated Projects: 0 results

# of Collaborated Products: 4 results
25. TAKASHIMA Seiji

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results
26. IMAMURA Hiromi

# of Collaborated Projects: 0 results

# of Collaborated Products: 4 results
27. SUZUKI Takeo

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
28. 小倉尚志

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
29. 北風政史

# of Collaborated Projects: 0 results

# of Collaborated Products: 5 results
30. 吉川信也

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
31. 新沢伊藤恭子

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results
32. 木岡秀隆

# of Collaborated Projects: 0 results

# of Collaborated Products: 7 results
33. 小室一成

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
34. 目野主税

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
35. 八代健太

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
36. 鈴木勉

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
37. 川原裕之

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
38. 坂田泰史

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
39. 松岡研

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
40. 野地博行

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
41. 鈴木俊治

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
42. 藤川誠

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

SHINTANI YASUNORI 新谷 泰範

SHINTANI Yasunori 新谷 泰範

Research Projects

Research Products

Co-Researchers

遠隔虚血コンディショニングによる心不全発症・進展抑止効果とそのメカニズムの検討

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

新規メカノストレス因子による筋疾患への治療介入およびQOL維持への貢献

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

心筋内炎症の鍵となる介在板分子は拡張型心筋症の予後を規定するか？Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Elucidation of the mechanism in which mechanostress modulates cardiac microtubules dynamicsPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Analysis of the regulatory mechanism of the activity of cardiac specific myosin light chain kinase

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

A novel AMPK singaling at the intercalated disc in heartPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

anti-atherosclerotic and anti-cancer effects of AMPK activation

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] The CR9 element is a novel mechanical load‐responsive enhancer that regulates natriuretic peptide genes expression2021

Author(s)

Journal Title

DOI

Data Source

[Journal Article] In vivo real‐time ATP imaging in zebrafish hearts reveals G0s2 induces ischemic tolerance2020

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Higd1a improves respiratory function in the models of mitochondrial disorder2020

Author(s)

Journal Title

DOI

Data Source

[Journal Article] AMPK regulates cell shape of cardiomyocytes by modulating turnover of microtubules through CLIP‐1702020

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Endocardium differentiation through Sox17 expression in endocardium precursor cells regulates heart development in mice.2019

Author(s)

Journal Title

DOI

Data Source

[Journal Article] A molecular triage process mediated by RING finger protein 126 and BCL2-associated athanogene 6 regulates degradation of G0/G1 switch gene 2.2019

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Cell Size Critically Determines Initial Retention of Bone Marrow Mononuclear Cells in the Heart after Intracoronary Injection: Evidence from a Rat Model.2016

Author(s)

Journal Title

SHINTANI YASUNORI 新谷泰範

SHINTANI Yasunori 新谷泰範