Yokoyama Takeshi 横山武司

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yokoyama takeshi 横山武司

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Researcher Number	20719447
Other IDs
Affiliation (Current)	2025: 東北大学, 生命科学研究科, 助教
Affiliation (based on the past Project Information) *help	2019 – 2025: 東北大学, 生命科学研究科, 助教
Review Section/Research Field	Principal Investigator Complex systems / Basic Section 54030:Infectious disease medicine-related / Basic Section 43020:Structural biochemistry-related Except Principal Investigator Medium-sized Section 37:Biomolecular chemistry and related fields / Basic Section 38030:Applied biochemistry-related / Medium-sized Section 43:Biology at molecular to cellular levels, and related fields / Basic Section 43020:Structural biochemistry-related
Keywords	Principal Investigator クライオ電子顕微鏡 / リボソーム / 単粒子解析 / RNA / 生命金属 / マグネシウム / 無細胞翻訳系 / 超分子複合体 / 合成生物学 / 黄色ブドウ球菌 … More / 生命金属科学 / 高速原子間力顕微鏡 / 透過型電子顕微鏡 / ヘモリジン / 膜孔形成毒素 / RNAポリメラーゼ / 転写 / 翻訳 … More Except Principal Investigator 蛋白質品質管理 / メゾスケール構造体 / 分泌経路 / セクレトーム解析 / コロナウイルス / 抗ウイルス / 抗ウイルス活性 / 糖結合タンパク質 / タンパク質 / 構造解析 / RNA-タンパク質複合体 / リボソーム / タンパク質複合体 / クライオ電顕 / RNA / 計算物理学 / 構造生物学 / 細胞分裂 / クライオ電子顕微鏡 / 質量分析計 / CryoEM / FtsZ / 分子動力学計算 / 機械学習 / 構造プロテオミクス / 透過型電子顕微鏡 / X線結晶構造解析 Less

感染性細菌リボソームを舞台とした抗菌薬誘導耐性メカニズムの分子基盤Principal Investigator
- Principal Investigator
  
  横山武司
- Project Period (FY)
  2025 – 2027
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 54030:Infectious disease medicine-related
- Research Institution
  Tohoku University
分泌経路におけるメゾスケール構造体プロファイリングの開拓
- Principal Investigator
  
  奥村正樹
- Project Period (FY)
  2023 – 2025
- Research Category
  
  Fund for the Promotion of Joint International Research (International Collaborative Research)
- Review Section
  
  Medium-sized Section 37:Biomolecular chemistry and related fields
- Research Institution
  Tohoku University
マグネシウム結合によるリボソーム活性制御の構造基盤Principal Investigator
- Principal Investigator
  
  横山武司
- Project Period (FY)
  2022 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
- Review Section
  
  Complex systems
- Research Institution
  Tohoku University
Structure-based functionalization of novel sugar-binding proteins derived from marine natural products for corona drug discovery
- Principal Investigator
  
  田中良和
- Project Period (FY)
  2022 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 38030:Applied biochemistry-related
- Research Institution
  Tohoku University
翻訳システムの合理的改変による人工制御Principal Investigator
- Principal Investigator
  
  横山武司
- Project Period (FY)
  2021 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
- Review Section
  
  Complex systems
- Research Institution
  Tohoku University
Elucidation of the polymerization mechanisms of bacterial FtsZ.
- Principal Investigator
  
  MATSUI Takashi
- Project Period (FY)
  2021 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 43020:Structural biochemistry-related
- Research Institution
  Kitasato University
Development of a method to determine RNA-protein complex by cryo-EM
- Principal Investigator
  
  田中良和
- Project Period (FY)
  2021 – 2024
- Research Category
  
  Grant-in-Aid for Challenging Research (Exploratory)
- Review Section
  
  Medium-sized Section 43:Biology at molecular to cellular levels, and related fields
- Research Institution
  Tohoku University
病原菌の鉄獲得プロセスの最上流で機能する膜孔形成毒素の分子機構の活写Principal Investigator
- Principal Investigator
  
  横山武司
- Project Period (FY)
  2020 – 2021
- Research Category
  
  Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
- Review Section
  
  Complex systems
- Research Institution
  Tohoku University
Structural insights into the transcription-translation complex revealed by cryo-EMPrincipal Investigator
- Principal Investigator
  
  yokoyama takeshi
- Project Period (FY)
  2019 – 2021
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 43020:Structural biochemistry-related
- Research Institution
  Tohoku University

All 2024 2023 2022 2021

All Journal Article Presentation Book

[Book] クライオ電子顕微鏡ハンドブック、第４章１４節、クライオ電子顕微鏡で見る、リボソームの「かたち」と「動き」2023
- Author(s)
  伴野　詢太，田中　良和，横山　武司
- Total Pages
  460
- Publisher
  NTS
- ISBN
  9784860438043
- Data Source
  KAKENHI-PROJECT-21K19201
[Journal Article] Structural insights into the decoding capability of isoleucine tRNAs with lysidine and agmatidine2024
- Author(s)
  Naho Akiyama, Kensuke Ishiguro, Takeshi Yokoyama, Kenjyo Miyauchi, Asuteka Nagao, Mikako Shirouzu, Tsutomu Suzuki
- Journal Title
  
  Nature Structural & Molecular Biology
  
  Volume: - Issue: 5 Pages: 817-825
- DOI
  10.1038/s41594-024-01238-1
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-23KJ0409, KAKENHI-PROJECT-23KK0105, KAKENHI-PROJECT-18H05272
[Journal Article] Boric acid intercepts 80S ribosome migration from AUG-stop by stabilizing eRF12024
- Author(s)
  Tanaka Mayuki、Yokoyama Takeshi、Saito Hironori、Nishimoto Madoka、Tsuda Kengo、Sotta Naoyuki、Shigematsu Hideki、Shirouzu Mikako、Iwasaki Shintaro、Ito Takuhiro、Fujiwara Toru
- Journal Title
  
  Nature Chemical Biology
  
  Volume: in press Issue: 5 Pages: 0-0
- DOI
  10.1038/s41589-023-01513-0
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-23KK0105, KAKENHI-PLANNED-18H05490, KAKENHI-PROJECT-19H05637, KAKENHI-PUBLICLY-22H04795, KAKENHI-PLANNED-21H05281, KAKENHI-PROJECT-22H04922
[Journal Article] Direct visualization of ribosomes in the cell-free system revealed the functional evolution of aminoglycoside2024
- Author(s)
  Tomono Junta、Asano Kosuke、Chiashi Takuma、Suzuki Masato、Igarashi Masayuki、Takahashi Yoshiaki、Tanaka Yoshikazu、Yokoyama Takeshi
- Journal Title
  
  The Journal of Biochemistry
  
  Volume: in press Issue: 6 Pages: 587-598
- DOI
  10.1093/jb/mvae002
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-21K19201, KAKENHI-PROJECT-23KK0105, KAKENHI-PROJECT-23K06556, KAKENHI-PROJECT-19KK0178, KAKENHI-PUBLICLY-22H04795, KAKENHI-PLANNED-21H05260
[Journal Article] Synthesis of epitope-targeting nanobody based on native protein-protein interactions for FtsZ filamentation suppressor.2023
- Author(s)
  Hikaru Nakazawa, Taiji Katsuki, Takashi Matsui, Atsushi Tsugita, Takeshi Yokoyama, Tomoyuki Ito, Sakiya Kawada, Yoshikazu Tanaka, Mitsuo Umetsu
- Journal Title
  
  Biotechnology journal
  
  Volume: 18 Issue: 11 Pages: 2300039-2300039
- DOI
  10.1002/biot.202300039
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-22K18911, KAKENHI-PROJECT-21K06036, KAKENHI-PLANNED-21H05260, KAKENHI-PROJECT-23K26463
[Journal Article] Dose-response relationship for the resistance of human insulin to degradation by insulin-degrading enzyme2023
- Author(s)
  Okumura Masaki、Kuramochi Tsubura、Lin Yuxi、Furukawa Ran、Mizutani Kenji、Yokoyama Takeshi、Kim Mingeun、Lim Mi Hee、Yi Hyon-Seung、Arai Kenta、Yamaguchi Hiroshi、Hojo Hironobu、Iwaoka Michio、Tanaka Yoshikazu、Park Sam-Yong、Inaba Kenji、Kanemura Shingo、Lee Young-Ho
- Journal Title
  
  bioRxiv
  
  Volume: 2023.04.08. Pages: 536135-536135
- DOI
  10.1101/2023.04.08.536135
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-23KK0105, KAKENHI-PLANNED-21H05095, KAKENHI-PROJECT-23K23464
[Journal Article] Glycosylated queuosines in tRNAs optimize translational rate and post-embryonic growth2023
- Author(s)
  Zhao Xuewei、Ma Ding、Ishiguro Kensuke、Saito Hironori、Akichika Shinichiro、Matsuzawa Ikuya、Mito Mari、Irie Toru、Ishibashi Kota、Wakabayashi Kimi、Sakaguchi Yuriko、Yokoyama Takeshi、Mishima Yuichiro、Shirouzu Mikako、Iwasaki Shintaro、Suzuki Takeo、Suzuki Tsutomu
- Journal Title
  
  Cell
  
  Volume: 186 Issue: 25 Pages: 5517-5535.e24
- DOI
  10.1016/j.cell.2023.10.026
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-23KK0105, KAKENHI-PROJECT-18H05272, KAKENHI-PLANNED-21H05280, KAKENHI-PROJECT-22H04922, KAKENHI-PROJECT-23K23475
[Journal Article] A marine sponge-derived lectin reveals hidden pathway for thrombopoietin receptor activation2022
- Author(s)
  Watari Hiromi、Kageyama Hiromu、Masubuchi Nami、Nakajima Hiroya、Onodera Kako、Focia Pamela J.、Oshiro Takumi、Matsui Takashi、Kodera Yoshio、Ogawa Tomohisa、Yokoyama Takeshi、Hirayama Makoto、Hori Kanji、Freymann Douglas M.、Imai Misa、Komatsu Norio、Araki Marito、Tanaka Yoshikazu、Sakai Ryuichi
- Journal Title
  
  Nature Communications
  
  Volume: 13 Issue: 1 Pages: 7262-7262
- DOI
  10.1038/s41467-022-34921-2
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21K06036, KAKENHI-PROJECT-21K08405, KAKENHI-PROJECT-21K18321, KAKENHI-PROJECT-21K19201, KAKENHI-PROJECT-22K20589, KAKENHI-PROJECT-19KK0178, KAKENHI-PUBLICLY-21H05712, KAKENHI-PROJECT-19H00918, KAKENHI-PROJECT-23K23695, KAKENHI-PROJECT-23K24176
[Journal Article] The carbohydrate tail of landomycin A is responsible for its interaction with the repressor protein LanK2022
- Author(s)
  Tsugita Atsushi、Uehara Shiro、Matsui Takashi、Yokoyama Takeshi、Ostash Iryna、Deneka Maksym、Yalamanchili Subbarao、Bennett Clay S.、Tanaka Yoshikazu、Ostash Bohdan
- Journal Title
  
  The FEBS Journal
  
  Volume: － Issue: 19 Pages: 6038-6057
- DOI
  10.1111/febs.16460
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21K06036, KAKENHI-PROJECT-21K19201, KAKENHI-PROJECT-19KK0178, KAKENHI-PUBLICLY-21H05712
[Journal Article] Chimeric mutants of staphylococcal hemolysin, which act as both one‐component and two‐component hemolysin, created by grafting the stem domain2022
- Author(s)
  Ghanem Nouran、Kanagami Natsuki、Matsui Takashi、Takeda Kein、Kaneko Jun、Shiraishi Yasuyuki、Choe Christian A.、Uchikubo‐Kamo Tomomi、Shirouzu Mikako、Hashimoto Tsubasa、Ogawa Tomohisa、Matsuura Tomoaki、Huang Po‐Ssu、Yokoyama Takeshi、Tanaka Yoshikazu
- Journal Title
  
  The FEBS Journal
  
  Volume: 11 Issue: 12 Pages: 11-20
- DOI
  10.1111/febs.16354
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17H00888, KAKENHI-PUBLICLY-20H05492, KAKENHI-PROJECT-19H02519, KAKENHI-PROJECT-21K06036, KAKENHI-PROJECT-21K19201, KAKENHI-PROJECT-19KK0178, KAKENHI-PLANNED-21H05228
[Presentation] 小胞体ストレスセンサーIRE1の多量体形成ポテンシャルとストレス感知2023
- Author(s)
  松崎元紀、横山武司、次田篤史、金村進吾、田尻道子、明石知子、野井健太郎、齋尾智英、稲葉謙次、奥村正樹
- Organizer
  第23回日本蛋白質科学会年会
- Data Source
  KAKENHI-PROJECT-23KK0105
[Presentation] 小胞体ストレスセンサーIRE1 によるストレス感知と越膜シグナル変換の分子機構2023
- Author(s)
  松崎元紀、横山武司、次田篤史、金村進吾、田尻道子、明石知子、野井健太郎、齋尾智英、稲葉謙次、奥村正樹
- Organizer
  第96回日本生化学会
- Data Source
  KAKENHI-PROJECT-23KK0105
[Presentation] 高濃度PEG含有タンパク質結晶からのLC-MSによるアミノ酸配列解析2022
- Author(s)
  大城拓未, 影山大夢, 小野寺かこ, 辺浩美, 中島寛也, 小川智久, 横山武司, 田中良和, 酒井隆一, 松井崇, 小寺義男
- Organizer
  第22回日本蛋白質科学会年会
- Data Source
  KAKENHI-PROJECT-21K06036
[Presentation] Controlling a supra-assembly dedicated to protein synthesis: optogenetic control of ribosomes in cell2022
- Author(s)
  Takeshi Yokoyama
- Organizer
  日本生物物理学会年会
- Data Source
  KAKENHI-PUBLICLY-21H00380
[Presentation] クライオ電子顕微鏡単粒子解析を用いた、非結核性抗酸菌の薬剤耐性因子によるリボソーム解離機構の解明2022
- Author(s)
  千足啄馬、高田希美、橋本翼、深野華子、山本健太郎、鈴木仁人、星野仁彦、横山武司、田中良和
- Organizer
  第45回日本分子生物学会年会
- Data Source
  KAKENHI-PROJECT-21K19201
[Presentation] Crystal structure analysis of LanK complexed with landomycinA, a potent antitumor antibiotic2022
- Author(s)
  Atsushi Tsugita, Shiro Uehara, Takashi Matsui, Takeshi Yokoyama, Iryna Ostash, Maksym Deneka, Subbarao Yalamanchili, Clay S. Bennett, Bohdan Ostash, and YoshikazuTanaka
- Organizer
  e-Asia Joint Symposium on “Marine Biodiversity as a Source of New Chemotypes
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21K19201
[Presentation] 非結核性抗酸菌Mycobacterium abscessusリボソームにおけるマクロライド耐性機構の解明を目指したクライオ電子顕微鏡構造解析2022
- Author(s)
  橋本翼、高田希美、千足啄馬、深野華子、山本健太郎、鈴木仁人、星野仁彦、横山武司、田中良和
- Organizer
  2021年度生物物理学会、北海道支部・東北支部合同例会
- Data Source
  KAKENHI-PROJECT-21K19201
[Presentation] クライオ電子顕微鏡単粒子解析による、リボソームを標的とするアミノ配糖体抗菌薬の微細構造差が生み出す阻害活性増強機構の解明2022
- Author(s)
  浅野航佑、伴野詢太、鈴木仁人、横山武司、田中良和
- Organizer
  第45回日本分子生物学会年会
- Data Source
  KAKENHI-PROJECT-21K19201
[Presentation] 高濃度PEG含有タンパク質結晶からのLC-MSによるアミノ酸解析2022
- Author(s)
  大城拓未, 影山大夢, 小野寺かこ, 辺浩美, 中島寛也, 小川智久, 横山武司, 田中良和, 酒井隆一, 松井崇, 小寺義男
- Organizer
  日本プロテオーム学会2022年大会
- Data Source
  KAKENHI-PROJECT-21K06036
[Presentation] ストップコドンリードスルーにおける誤翻訳アミノ酸の同定2022
- Author(s)
  須藤愛莉咲, 浅野航佑, 原口大輝, 小川智久, 横山武司, 田中良和, 松井崇, 小寺義男
- Organizer
  日本プロテオーム学会2022年大会
- Data Source
  KAKENHI-PROJECT-21K06036
[Presentation] Elucidation of the binding mode of a macrolide antibiotic to NTM ribosome for understanding drug resistance mechanism by using cryo-EM2021
- Author(s)
  Tsubasa Hashimoto, Nozomi Takada, Takuma Chiashi, Hanako Fukano, Kentaro Yamamoto, Masato Suzuki, Yoshihiko Hoshino, Takeshi Yokoyama, Yoshikazu Tanaka
- Organizer
  第59回日本生物物理学会年会
- Data Source
  KAKENHI-PROJECT-21K19201
[Presentation] クライオ電子顕微鏡単粒子解析法によるウサギ赤血球ライセートに内在する80Sリボソーム構造解析の検討2021
- Author(s)
  千足啄馬、横山武司、田中良和
- Organizer
  第44回日本分子生物学会年会
- Data Source
  KAKENHI-PROJECT-21K19201
[Presentation] Elucidation of new action mechanism of aminoglycoside antibiotics on ribosomes using single particle cryo-electron microscopy2021
- Author(s)
  Junta Tomono，Kosuke Asano，Masato Suzuki, Takeshi Yokoyama，Yoshikazu Tanaka
- Organizer
  第59回日本生物物理学会年会
- Data Source
  KAKENHI-PROJECT-21K19201
[Presentation] 黄色ブドウ球菌膜孔形成毒素ステムドメインの改変による膜孔形成能の考察2021
- Author(s)
  横山武司、ガネムノーラン、金上奈津希、松井崇、橋本翼、小川智久、田中良和
- Organizer
  第94回日本細菌学会総会、シンポジウム「生命金属の新潮流」
- Invited
- Data Source
  KAKENHI-PUBLICLY-20H05492
[Presentation] 新規レクチン様タンパク質の構造と機能の解析2021
- Author(s)
  影山大夢, 小野寺かこ, 松井崇, 小川智久, 横山武司, 田中良和
- Organizer
  第21回日本蛋白質科学会年会
- Data Source
  KAKENHI-PROJECT-21K06036
[Presentation] 海洋天然物由来の新規生理活性タンパク質の構造機能解析2021
- Author(s)
  田中良和, 影山大夢, 辺ひろみ, 増渕菜弥, 中島寛也, 小野寺かこ, 大城拓未, 松井崇, 小寺義男, 小川智久, 横山武司, 小松則夫, 荒木真理人, 酒井隆一
- Organizer
  第94回日本生化学会大会
- Data Source
  KAKENHI-PROJECT-21K06036
[Presentation] Cryo-EM visualizes ribosomes in mammalian cell free translation system2021
- Author(s)
  Takuma Chiashi, Takeshi Yokoyama, Yoshikazu Tanaka
- Organizer
  日本・ウクライナ・タイ二国間交流事業合同シンポジウム
- Data Source
  KAKENHI-PROJECT-21K19201
[Presentation] 薬剤耐性獲得機構の解明に向けた、クライオ電子顕微鏡単粒子解析による非結核性抗酸菌Mycobacterium abscessusリボソームへのマクロライド結合様式の解明2021
- Author(s)
  橋本翼、高田希美、千足啄馬、深野華子、山本健太郎、鈴木仁人、星野仁彦、横山武司、田中良和
- Organizer
  第44回日本分子生物学会年会
- Data Source
  KAKENHI-PROJECT-21K19201
[Presentation] クライオ電子顕微鏡単粒子解析によるリボソームを標的としたアミノ配糖体抗菌薬の新規作用機序の解明2021
- Author(s)
  伴野詢太、浅野航佑、鈴木仁人、横山武司、田中良和
- Organizer
  第44回日本分子生物学会年会
- Data Source
  KAKENHI-PROJECT-21K19201

1. MATSUI Takashi (30463582)

# of Collaborated Projects: 2 results

# of Collaborated Products: 7 results
2. 田中良和 (20374225)

# of Collaborated Projects: 2 results

# of Collaborated Products: 12 results
3. 渡辺豪 (80547076)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
4. 長尾翌手可 (30588017)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
5. 高田礼人 (10292062)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
6. 酒井隆一 (20265721)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
7. 奥村正樹 (50635810)

# of Collaborated Projects: 1 results

# of Collaborated Products: 3 results
8. 村岡貴博 (70509132)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
9. 松崎元紀 (90817040)

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
10. 中澤光

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
11. 松浦友亮

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Yokoyama Takeshi 横山 武司

yokoyama takeshi 横山 武司

Research Projects

Research Products

Co-Researchers

感染性細菌リボソームを舞台とした抗菌薬誘導耐性メカニズムの分子基盤Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

分泌経路におけるメゾスケール構造体プロファイリングの開拓

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

マグネシウム結合によるリボソーム活性制御の構造基盤Principal Investigator

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Structure-based functionalization of novel sugar-binding proteins derived from marine natural products for corona drug discovery

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翻訳システムの合理的改変による人工制御Principal Investigator

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Elucidation of the polymerization mechanisms of bacterial FtsZ.

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Development of a method to determine RNA-protein complex by cryo-EM

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病原菌の鉄獲得プロセスの最上流で機能する膜孔形成毒素の分子機構の活写Principal Investigator

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Structural insights into the transcription-translation complex revealed by cryo-EMPrincipal Investigator

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[Book] クライオ電子顕微鏡ハンドブック、第４章１４節、クライオ電子顕微鏡で見る、リボソームの「かたち」と「動き」2023

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[Journal Article] Structural insights into the decoding capability of isoleucine tRNAs with lysidine and agmatidine2024

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[Journal Article] Boric acid intercepts 80S ribosome migration from AUG-stop by stabilizing eRF12024

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[Journal Article] Direct visualization of ribosomes in the cell-free system revealed the functional evolution of aminoglycoside2024

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Yokoyama Takeshi 横山武司

yokoyama takeshi 横山武司