Yamazaki Hiromi 山嵜博未

… Alternative Names

YAMAZAKI Hiromi 山嵜博未

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Researcher Number	20720915
Other IDs
Affiliation (Current)	2025: 大阪大学, 大学院医学系研究科, 助教 2025: 公益財団法人神戸医療産業都市推進機構, その他部局等, 研究員(上席・主任研究員クラス)
Affiliation (based on the past Project Information) *help	2021 – 2024: 公益財団法人神戸医療産業都市推進機構, その他部局等, 研究員(上席・主任研究員クラス) 2022: 公益財団法人神戸医療産業都市推進機構, 先端医療研究センター, 特別研究員(RPD) 2017 – 2019: 弘前大学, 医学研究科, 助教 2014 – 2015: 弘前大学, 医学(系)研究科(研究院), 助教
Review Section/Research Field	Principal Investigator General medical chemistry / Medium-sized Section 54:Internal medicine of the bio-information integration and related fields / Basic Section 54010:Hematology and medical oncology-related Except Principal Investigator Basic Section 54010:Hematology and medical oncology-related
Keywords	Principal Investigator 急性骨髄性白血病 / GCN1 / 酸化ストレス / アミノ酸飢餓 / 造血 / 酸化ストレス応答 / 骨髄異形成症候群 / フェロトーシス / GPX4 / MLL-AF9 … More / レドックス / 造血幹細胞 / セレノプロテイン / 脂質過酸化 / Bリンパ球 / GCN1L1 / 成長遅延 / 胎生致死 / ノックアウトマウス / アミノ酸飢餓応答 / 翻訳制御因子 / 細胞増殖 / GCN2 / ストレス応答 / 翻訳制御 / Nrf2 … More Except Principal Investigator 急性骨髄性白血病 / LAT1 / SLC7A5 / アミノ酸トランスポーター Less

酸化ストレスによる一細胞レベルの細胞変容と応答系の解析ツール創出Principal Investigator
- Principal Investigator
  
  山嵜博未
- Project Period (FY)
  2024 – 2025
- Research Category
  
  Grant-in-Aid for Challenging Research (Exploratory)
- Review Section
  
  Medium-sized Section 54:Internal medicine of the bio-information integration and related fields
- Research Institution
  Foundation for Biomedical Research and Innovation at Kobe
オートファジー・アミノ酸代謝に基づいた難治性白血病の病態解明と治療応用Research Fellow
- Principal Investigator
  
  山嵜博未
- Research Fellow
  
  山嵜博未
- Project Period (FY)
  2022 – 2024
- Research Category
  
  Grant-in-Aid for JSPS Fellows
- Review Section
  
  Basic Section 54010:Hematology and medical oncology-related
- Research Institution
  Foundation for Biomedical Research and Innovation at Kobe
レドックス制御に基づいた急性骨髄性白血病の治療応用Principal Investigator
- Principal Investigator
  
  山嵜博未
- Project Period (FY)
  2021 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 54010:Hematology and medical oncology-related
- Research Institution
  Foundation for Biomedical Research and Innovation at Kobe
Mechanisms of translation regulation by a ribosome-binding factor GCN1L1Principal Investigator
- Principal Investigator
  
  Yamazaki Hiromi
- Project Period (FY)
  2017 – 2019
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  General medical chemistry
- Research Institution
  Hirosaki University
Analysis of a novel stress response system exerting neuroprotective effectsPrincipal Investigator
- Principal Investigator
  
  YAMAZAKI Hiromi
- Project Period (FY)
  2014 – 2015
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  General medical chemistry
- Research Institution
  Hirosaki University

All 2023 2022 2021 2020 2019 2018 2017 2015 2014 Other

All Journal Article Presentation Other

[Journal Article] Inducible Systemic Gcn1 Deletion in Mice Leads to Transient Body Weight Loss upon Tamoxifen Treatment Associated with Decrease of Fat and Liver Glycogen Storage2022
- Author(s)
  Liu Jun、Kasai Shuya、Tatara Yota、Yamazaki Hiromi、Mimura Junsei、Mizuno Seiya、Sugiyama Fumihiro、Takahashi Satoru、Sato Tsubasa、Ozaki Taku、Tanji Kunikazu、Wakabayashi Koichi、Maeda Hayato、Mizukami Hiroki、Shinkai Yasuhiro、Kumagai Yoshito、Tomita Hirofumi、Itoh Ken
- Journal Title
  
  International Journal of Molecular Sciences
  
  Volume: 23 Issue: 6 Pages: 3201-3201
- DOI
  10.3390/ijms23063201
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18H05293, KAKENHI-PROJECT-21K08432, KAKENHI-ORGANIZER-21H05258, KAKENHI-PUBLICLY-22H05555, KAKENHI-PROJECT-20H04340, KAKENHI-PUBLICLY-22H04799
[Journal Article] Dysregulated minor intron splicing in cancer.2022
- Author(s)
  Nishimura K*, Yamazaki H*, Zang W, Inoue D.
- Journal Title
  
  Cancer Science
  
  Volume: 113 Issue: 9 Pages: 2934-2942
- DOI
  10.1111/cas.15476
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-21K08432, KAKENHI-PROJECT-22K19475, KAKENHI-PROJECT-21K20936, KAKENHI-PROJECT-20H03717
[Journal Article] Sulforaphane Increase Mitochondrial Biogenesis-Related Gene Expression in the Hippocampus and Suppresses Age-Related Cognitive Decline in Mice.2022
- Author(s)
  Shimizu S, Kasai S, Yamazaki H, Tatara Y, Mimura J, Engler MJ, Tanji K, Nikaido Y, Inoue T, Suganuma H, Wakabayashi K, Itoh K.
- Journal Title
  
  International Journal of Molecular Sciences.
  
  Volume: 23(6) Issue: 15 Pages: 8433-8433
- DOI
  10.3390/ijms23158433
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-21K08432, KAKENHI-PROJECT-20K06887
[Journal Article] Aberrant <i>EVI1</i> splicing contributes to <i>EVI1</i>-rearranged leukemia2022
- Author(s)
  Tanaka Atsushi、Kunimoto Hiroyoshi et al.
- Journal Title
  
  Blood
  
  Volume: 140 Issue: 8 Pages: 875-888
- DOI
  10.1182/blood.2021015325
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21K08400, KAKENHI-PROJECT-21K08432, KAKENHI-PROJECT-21K12239, KAKENHI-PROJECT-22KK0119, KAKENHI-PROJECT-22H04925, KAKENHI-PROJECT-20H03714, KAKENHI-PROJECT-21H02948, KAKENHI-PROJECT-21J15620, KAKENHI-PROJECT-20H03717, KAKENHI-PROJECT-23K24368
[Journal Article] Pathological substrate of memory impairment in multiple system atrophy2022
- Author(s)
  Miki Yasuo、Tanji Kunikazu、Shinnai Kana、Tanaka Makoto T.、Altay Firat、et al.
- Journal Title
  
  Neuropathology and Applied Neurobiology
  
  Volume: 48 Issue: 7
- DOI
  10.1111/nan.12844
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21K07452, KAKENHI-PROJECT-21K08432, KAKENHI-PROJECT-22K11747, KAKENHI-PROJECT-20K06887, KAKENHI-PROJECT-23K24209
[Journal Article] Minor intron retention drives clonal hematopoietic disorders and diverse cancer predisposition2021
- Author(s)
  Inoue D, Polaski JT, Taylor J, Castel P, Chen S, Kobayashi S, Hogg SJ, Hayashi Y, Fukumoto M, Yamazaki H, Tanaka A, Fukui C, Chew GL, McCormick F, Bradley RK, Abdel-Wahab O.
- Journal Title
  
  Nature Genetics
  
  Volume: 21 Issue: 5 Pages: 828-828
- DOI
  10.1038/s41588-021-00828-9
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20H00537, KAKENHI-PROJECT-21K08432, KAKENHI-PROJECT-22KJ3215
[Journal Article] Ribosome binding protein GNC1 regulates the cell cycle and cell proliferation and is essential for the embryonic development of mice2020
- Author(s)
  Yamazaki H,Kasai S,Mimura J,Ye P,Inose-Maruyama A,Tanji K,Wakabayashi K,Mizuno S,Sugiyama F,Takahashi S,Sato T,Ozaki T,Cavener DR,Yamamoto M,Itoh K
- Journal Title
  
  PloS Genet.
  
  Volume: 16 Issue: 4 Pages: e1008693-e1008693
- DOI
  10.1371/journal.pgen.1008693
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K06910, KAKENHI-PROJECT-17K08616, KAKENHI-PROJECT-18H02533
[Journal Article] Emerging evidence for crosstalk between Nrf2 and mitochondria in physiological homeostasis and in heart disease.2020
- Author(s)
  Tsushima M, Liu J, Hirao W, Yamazaki H, Tomita H, Itoh K.
- Journal Title
  
  Archives of Pharmacal Research.
  
  Volume: 43 Issue: 3 Pages: 286-296
- DOI
  10.1007/s12272-019-01188-z
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17K08616
[Journal Article] Role of the ISR-ATF4 pathway and its cross talk with Nrf2 in mitochondrial quality control2019
- Author(s)
  Kasai S, Yamazaki H, Tanji K, Engler MJ, Matsumiya T, Itoh K.
- Journal Title
  
  Journal of Clinical Biochemistry and Nutrition
  
  Volume: 64 Issue: 1 Pages: 1-12
- DOI
  10.3164/jcbn.18-37
- NAID
  130007542293
- ISSN
  0912-0009, 1880-5086
- Language
  English
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K08616, KAKENHI-PROJECT-17K10012, KAKENHI-PLANNED-26111010, KAKENHI-PROJECT-17K07089
[Journal Article] Concomitant Nrf2- and ATF4-activation by Carnosic Acid Cooperatively Induces Expression of Cytoprotective Genes.2019
- Author(s)
  Mimura J, Inose-Maruyama A, Taniuchi S, Kosaka K, Yoshida H, Yamazaki H, Kasai S, Harada N, Kaufman RJ, Oyadomari S, Itoh K.
- Journal Title
  
  International Journal of Molecular Sciences
  
  Volume: 20 Issue: 7 Pages: 1706-1706
- DOI
  10.3390/ijms20071706
- NAID
  120006939608
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K08616, KAKENHI-PLANNED-26111010
[Journal Article] Nrf2の抗老化因子としての役割2017
- Author(s)
  山嵜博未, Engler Mate Janos, 伊東健
- Journal Title
  
  循環制御
  
  Volume: 38
- Data Source
  KAKENHI-PROJECT-17K08616
[Journal Article] Role of the Keap1/Nrf2 pathway in neurodegenerative diseases.2015
- Author(s)
  Yamazaki H, Tanji K, Wakabayashi K, Matsuura S, Itoh K.
- Journal Title
  
  Pathol Int
  
  Volume: 65 Issue: 5 Pages: 210-9
- DOI
  10.1111/pin.12261
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-26860178, KAKENHI-PLANNED-26111010, KAKENHI-PROJECT-25293064
[Journal Article] A Remote GATA2 Hematopoietic Enhancer Drives Leukemogenesis in inv(3)(q21 ; q26) by Activating EVI1 Expression2014
- Author(s)
  Yamazaki H, Suzuki M, Otsuki A, Shimizu R, Bresnick EH, Engel JD, Yamamoto M.
- Journal Title
  
  Cancer Cell
  
  Volume: 25 Issue: 4 Pages: 415-427
- DOI
  10.1016/j.ccr.2014.02.008
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-12J08044, KAKENHI-PROJECT-24249015, KAKENHI-PROJECT-24591404, KAKENHI-PROJECT-24659142, KAKENHI-PROJECT-24659456, KAKENHI-PROJECT-24790957, KAKENHI-PROJECT-26670463, KAKENHI-PROJECT-26860178
[Presentation] Targeting the ATF4-LAT1-MYC Loop: Disrupting A Crucial Pathway in AML Development.2023
- Author(s)
  Hiromi Yamazaki, Hitomi Ito, Koutarou Nishimura, Yui Koike, Daichi Inoue.
- Organizer
  第85回日本血液学会学術集会
- Data Source
  KAKENHI-PROJECT-21K08432
[Presentation] Targeting the ATF4-LAT1-MYC Loop: Disrupting A Crucial Pathway in AML Development.2023
- Author(s)
  Hiromi Yamazaki, Hitomi Ito, Koutarou Nishimura, Yui Koike, Daichi Inoue.
- Organizer
  第85回日本血液学会学術集会
- Data Source
  KAKENHI-PROJECT-22KJ3215
[Presentation] ATF4-LAT1-MYCループ阻害によるAML発症の抑制機構.2023
- Author(s)
  山嵜博未、伊藤裕美、西村耕太郎、小池優依、井上大地.
- Organizer
  第96回日本生化学会大会
- Data Source
  KAKENHI-PROJECT-21K08432
[Presentation] アミノ酸代謝を標的とした造血器腫瘍の病態解明と治療応用2023
- Author(s)
  山嵜博未、伊藤裕美、西村耕太郎、小池優依、井上大地
- Organizer
  第76回酸化ストレス学会学術集会
- Data Source
  KAKENHI-PROJECT-21K08432
[Presentation] Pathogenic mechanisms of amino acid metabolism in acute myeloid leukemia.2023
- Author(s)
  Hiromi Yamazaki, Hitomi Ito, Koutarou Nishimura, Yui Koike, Daichi Inoue
- Organizer
  第20回幹細胞シンポジウム
- Data Source
  KAKENHI-PROJECT-21K08432
[Presentation] ATF4-LAT1-MYCループ阻害によるAML発症の抑制機構.2023
- Author(s)
  山嵜博未、伊藤裕美、西村耕太郎、小池優依、井上大地.
- Organizer
  第96回日本生化学会大会
- Data Source
  KAKENHI-PROJECT-22KJ3215
[Presentation] GCN1L1, a mouse homologue of eIF-2-alpha kinase activator GCN1, regulates cell cycle and cell proliferation and is essential for embryonic development in mice.2020
- Author(s)
  Hiromi Yamazaki, Shuya Kasai, Junsei Mimura, Peng Ye, Atsushi Inose-Maruyama, Tsubasa Sato, Ken Itoh.
- Organizer
  The Environmental Response V
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K08616
[Presentation] リボソーム結合因子GCN1L1によるストレス応答と細胞周期制御.2020
- Author(s)
  山嵜博未.
- Organizer
  レドックス・ライフイノベーション第170委員会20周年記念若手シンポジウム
- Data Source
  KAKENHI-PROJECT-17K08616
[Presentation] Ribosome binding protein GCN1L1 controls cell cycle and is essential for embryonic development2019
- Author(s)
  Hiromi Yamazaki, Shuya Kasai, Junsei Mimura, Peng Ye, Atsushi Inose Maruyama, Ken Itoh
- Organizer
  9th Federation of the Asian and Oceanian Physiological Societies Congress (FAOPS2019)
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K08616
[Presentation] Body weight loss in postnatal GCN1L1 knockout mice.2019
- Author(s)
  Jun Liu, Shuya Kasai, Hiromi Yamazaki, Junsei Mimura, Ken Itoh.
- Organizer
  第1回弘前メディカルサイエンスフォーラム
- Data Source
  KAKENHI-PROJECT-17K08616
[Presentation] Ribosome binding protein GCN1L1 knockout mice exhibit embryonic lethality with growth retardation and reduced cell proliferation2019
- Author(s)
  Shuya Kasai, Hiromi Yamazaki, Junsei Mimura, Peng Ye, Atsushi Inose-Maruyama, Ken Itoh
- Organizer
  The 9th Biennial Meeting of Society for Free Radical Research-Asia (SFRR-Asia 2019)
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K08616
[Presentation] リボソーム結合因子GCN1L1は細胞増殖制御および胎仔発生に必須である.2019
- Author(s)
  山嵜博未, 葛西秋宅, 三村純正, 叶鵬, 猪瀬-丸山敦史, 伊東健.
- Organizer
  第92回日本生化学会大会
- Data Source
  KAKENHI-PROJECT-17K08616
[Presentation] リボソーム結合因子GCN1L1による細胞増殖制御機構2018
- Author(s)
  山嵜博未、叶鵬、葛西秋宅、三村純正、猪瀬-丸山敦史、伊東健
- Organizer
  第91回日本生化学会大会
- Data Source
  KAKENHI-PROJECT-17K08616
[Presentation] リボゾーム結合因子GCN1L1によるDRG2を介した細胞増殖制御機構2018
- Author(s)
  山嵜博未、葛西秋宅、三村純正、伊東健
- Organizer
  レドックス研究会「生命のエネルギー獲得戦略における多様性と共通原理の理解にむけて」,岡崎カンファレンスセンター
- Data Source
  KAKENHI-PROJECT-17K08616
[Presentation] マウス発生におけるリボソーム結合性因子GCN1L1の役割2017
- Author(s)
  山嵜博未、叶鵬、葛西秋宅、三村純正、猪瀬-丸山敦史、伊東健
- Organizer
  2017年度生命科学系学会合同年次大会（ConBio2017） ,神戸ポートアイランド
- Data Source
  KAKENHI-PROJECT-17K08616
[Presentation] Screening of mitophagy inducers in HeLa cells.2015
- Author(s)
  Yamazaki H, Mimura J, Itoh K.
- Organizer
  6th world congress on targeting mitochondria
- Place of Presentation
  Berlin Germany
- Year and Date
  2015-10-28
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26860178
[]

1. 松宮朋穂 (30344592)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
2. SHINKAI Yasuhiro

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
3. 葛西秋宅

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
4. 伊藤昭博

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
5. 熊谷嘉人

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
6. 國本博義

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
7. 丹治邦和

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
8. 三木康生

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
9. 井上大地

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Yamazaki Hiromi 山嵜 博未

YAMAZAKI Hiromi 山嵜 博未

Research Projects

Research Products

Co-Researchers

酸化ストレスによる一細胞レベルの細胞変容と応答系の解析ツール創出Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

オートファジー・アミノ酸代謝に基づいた難治性白血病の病態解明と治療応用Research Fellow

Principal Investigator

Research Fellow

Project Period (FY)

Research Category

Review Section

Research Institution

レドックス制御に基づいた急性骨髄性白血病の治療応用Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Mechanisms of translation regulation by a ribosome-binding factor GCN1L1Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Analysis of a novel stress response system exerting neuroprotective effectsPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] Inducible Systemic Gcn1 Deletion in Mice Leads to Transient Body Weight Loss upon Tamoxifen Treatment Associated with Decrease of Fat and Liver Glycogen Storage2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Dysregulated minor intron splicing in cancer.2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Sulforaphane Increase Mitochondrial Biogenesis-Related Gene Expression in the Hippocampus and Suppresses Age-Related Cognitive Decline in Mice.2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Aberrant <i>EVI1</i> splicing contributes to <i>EVI1</i>-rearranged leukemia2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Pathological substrate of memory impairment in multiple system atrophy2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Minor intron retention drives clonal hematopoietic disorders and diverse cancer predisposition2021

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Ribosome binding protein GNC1 regulates the cell cycle and cell proliferation and is essential for the embryonic development of mice2020

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Emerging evidence for crosstalk between Nrf2 and mitochondria in physiological homeostasis and in heart disease.2020

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Role of the ISR-ATF4 pathway and its cross talk with Nrf2 in mitochondrial quality control2019

Author(s)

Journal Title

DOI

Yamazaki Hiromi 山嵜博未

YAMAZAKI Hiromi 山嵜博未