Saito Akira 齋藤晶

Researcher Number	20721608
Affiliation (Current)	2026: 自治医科大学, 医学部, 非常勤講師
Affiliation (based on the past Project Information) *help	2023 – 2024: 自治医科大学, 医学部, 非常勤講師
Review Section/Research Field	Principal Investigator Basic Section 55020:Digestive surgery-related Except Principal Investigator Basic Section 55020:Digestive surgery-related / Basic Section 57060:Surgical dentistry-related / Basic Section 50020:Tumor diagnostics and therapeutics-related
Keywords	Principal Investigator DPP-4阻害剤 / Metformin / NETs / Diabetes / がん微小環境 / マクロファージ / 腫瘍浸潤好中球 / 腫瘍浸潤リンパ球 / 好中球細胞外トラップ / メトホルミン / 糖尿病 / 大腸癌 … More Except Principal Investigator … More 腹膜播種 / flowcytometry / 免疫染色 / 胃癌 / Claudin18.2 / 免疫多様性 / OPMDs / 免疫組織化学染色 / 免疫化学組織染色 / 腫瘍微小環境 / 口腔癌 / 大網乳斑 / フローサイトメトリー / 腹水 / マクロファージ / T細胞 / 好酸球 / 腹腔内化学療法 / 腹膜 / 腹腔免疫 / 細胞外小胞 / 核酸医薬 / エクソソーム / アデノ随伴ウイルス / マイクロRNA / 膵癌 Less

Efficacy of anti-Claudin18.2 antibody for gastric cancer peritoneal dissemination
- Principal Investigator
  
  山口博紀
- Project Period (FY)
  2024 – 2026
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 55020:Digestive surgery-related
- Research Institution
  Jichi Medical University
Elucidation of neutrophil dynamics and its clinical significance in diabetic cancerPrincipal Investigator
- Principal Investigator
  
  Saito Akira
- Project Period (FY)
  2023 – 2024
- Research Category
  
  Grant-in-Aid for Early-Career Scientists
- Review Section
  
  Basic Section 55020:Digestive surgery-related
- Research Institution
  Jichi Medical University
Development of therapy of peritoneal dissemination using novel nucleic acid drugs and extracellular vesicles
- Principal Investigator
  
  大澤英之
- Project Period (FY)
  2023 – 2025
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 50020:Tumor diagnostics and therapeutics-related
- Research Institution
  Jichi Medical University
Intraperitoneal immune microenvironment in patients with peritoneal dissemination and its therapeutic application
- Principal Investigator
  
  倉科憲太郎
- Project Period (FY)
  2023 – 2025
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 55020:Digestive surgery-related
- Research Institution
  Jichi Medical University
30色多重免疫染色定量解析法を用いたOPMDs・口腔癌の腫瘍微小環境の解明
- Principal Investigator
  
  大本理恵 (川嶋理恵)
- Project Period (FY)
  2023 – 2025
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 57060:Surgical dentistry-related
- Research Institution
  Jichi Medical University

All 2025 2024 2023

All Journal Article Presentation

[Journal Article] Expression of Claudin18.2 in metastatic lesions in peritoneum of gastric cancer2025
- Author(s)
  Saito Akira、Ohzawa Hideyuki、Kawashima Rie、Matsumoto Shiro、Kazuya Takahashi 、Kurashina Kentaro、Saito Shin、Miyato Hideyo、Hosoya Yoshinori、Sata Naohiro、Kitayama Joji、Yamaguchi Hironori
- Journal Title
  
  Journal of Gastrointestinal Oncology
  
  Volume: 16 Issue: 1 Pages: 67-76
- DOI
  10.21037/jgo-24-743
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-23K19642, KAKENHI-PROJECT-24K11874
[Journal Article] Metformin Alters Tumor Immune Microenvironment, Improving the Outcomes of Breast Cancer Patients With Type 2 Diabetes Mellitus.2024
- Author(s)
  Shiba Satomi、Harao Michiko、Saito Akira、Sakuragi Masako、Kitayama Joji、Sata Naohiro.
- Journal Title
  
  Journal of Breast Cancer
  
  Volume: 27 Issue: 2 Pages: 121-121
- DOI
  10.4048/jbc.2023.0285
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-23K24411, KAKENHI-PROJECT-22K16450, KAKENHI-PROJECT-23K15503
[Journal Article] Intraperitoneal administration of adeno-associated virus encoding microRNA-29b for the treatment of peritoneal metastasis2024
- Author(s)
  Kaneko Yuki、Ohzawa Hideyuki、Kimura Yuki、Takahashi Rei、Matsumiya Misaki、Tamura Kohei、Futoh Yurie、Miyato Hideyo、Saito Shin、Yamaguchi Hironori、Hosoya Yoshinori、Watano Ryota、Mizukami Hiroaki、Sata Naohiro、Kitayama Joji
- Journal Title
  
  Cancer Gene Therapy
  
  Volume: 31 Issue: 12 Pages: 1818-1830
- DOI
  10.1038/s41417-024-00837-w
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23K27676, KAKENHI-PROJECT-23K06772, KAKENHI-PROJECT-24K23495
[Journal Article] 特集進行消化器癌に対するconversion surgeryのすべて II. 各論 2. 胃 2)胃癌腹膜播種に対する外科治療戦略2023
- Author(s)
  倉科憲太郎、北山丈二、山口博紀、齋藤心、大澤英之、金丸理人、高橋和也、金子勇貴、細谷好則、佐田尚宏
- Journal Title
  
  外科
  
  Volume: 85 Issue: 13 Pages: 1394-1400
- DOI
  10.15106/j_geka85_1394
- ISSN
  0016-593X, 2432-9428
- Year and Date
  2023-12-01
- Data Source
  KAKENHI-PROJECT-23K08117
[Journal Article] Metformin may improve the outcome of patients with colorectal cancer and type 2 diabetes mellitus partly through effects on neutrophil extracellular traps.2023
- Author(s)
  Akira Saito, Koji Koinuma, Rie Kawashima, Hideyo Miyato, Hideyuki Ohzawa, Hisanaga Horie, Hironori Yamaguchi, Hiroshi Kawahira, Toshiki Mimura, Joji Kitayama and Naohiro Sata
- Journal Title
  
  British Journal of Cancer Reports
  
  Volume: - Issue: 1
- DOI
  10.1038/s44276-023-00022-w
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-23K15503
[Presentation] 腹腔内化学療法に伴う腹腔内好酸球の動態と治療効果との相関性2025
- Author(s)
  松宮美沙希; 倉科憲太郎; 大澤英之; 高橋礼; 水津枝理; 髙橋和也; 松本志郎; 園田洋史; 宮戸秀世; 齋藤心; 細谷好則; 佐田尚宏; 北山丈二; 山口博紀.
- Organizer
  第97回日本胃癌学会総会
- Data Source
  KAKENHI-PROJECT-23K08117
[Presentation] メトホルミンは腫瘍の微小環境を修飾し、浸潤性膵管癌の予後を改善する2025
- Author(s)
  高橋礼; 齋藤晶; 水津枝里; 松宮美沙希; 園田洋史; 大澤英之; 宮戸秀世; 山口博紀; 佐田尚宏; 北山丈二.
- Organizer
  第58回日本成人病（生活習慣病）学会学術集会
- Data Source
  KAKENHI-PROJECT-23K15503
[Presentation] メトホルミン内服が根治切除を受けた浸潤性膵管癌の予後に与える影響2024
- Author(s)
  高橋礼; 齋藤晶; 木村有希; 青木裕一; 田口昌延; 森嶋計; 宮戸秀世; 大澤英之; 遠藤和洋; 笹沼英紀; 山口博紀; 佐久間康成; 川平洋; 堀江久永; 細谷好則; 味村俊樹; 味村俊樹; 北山丈二; 佐田尚宏.
- Organizer
  第55回日本膵臓学会大会
- Data Source
  KAKENHI-PROJECT-23K15503
[Presentation] 治癒切除を受けた膵癌患者の予後に与える抗糖尿病薬の影響2024
- Author(s)
  高橋礼; 齋藤晶; 木村有希; 青木裕一; 田口昌延; 森嶋計; 宮戸秀世; 大澤英之; 遠藤和洋; 笹沼英紀; 山口博紀; 佐久間康成; 川平洋; 堀江久永; 細谷好則; 味村俊樹; 北山丈二; 佐田尚宏.
- Organizer
  第124回日本外科学会定期学術集会
- Data Source
  KAKENHI-PROJECT-23K15503
[Presentation] 糖尿病における好中球細胞外トラップ形成の亢進は胃癌腹膜播種を促進する2024
- Author(s)
  高橋礼; 大澤英之; 金子勇貴; 齋藤晶; 水津枝理; 松宮美沙希; 田村昂平; 風當ゆりえ; 園田洋史; 宮戸秀世; 山口博紀; 佐田尚宏; 北山丈二.
- Organizer
  第83回日本癌学会学術総会
- Data Source
  KAKENHI-PROJECT-23K15503
[Presentation] 胃癌腹膜播種患者における腹腔内免疫細胞の解析2024
- Author(s)
  松宮美沙希; 髙橋和也; 宮戸秀世; 倉科憲太郎; 齋藤心; 大澤英之; 山口博紀; 細谷好則; 佐田尚宏; 北山丈二.
- Organizer
  第79回日本消化器外科学会総会
- Data Source
  KAKENHI-PROJECT-23K08117
[Presentation] The enhanced formation of neutrophil extracellular traps(NETs) may contribute to peritoneal metastasis in diabetic conditions.2024
- Author(s)
  Rei Takahashi; Hideyuki Ohzawa; Akira Saito; Yuki Kaneko; Misaki Matsumiya; Kohei Tamura; Yurie Futoh; Kazuya Takahashi; Yuki Kimura; Hirofumi Sonoda; Hideyo Miyado; Naohiro Sata; Joji Kitayama.
- Organizer
  第22回自治医科大学シンポジウム2024
- Data Source
  KAKENHI-PROJECT-23K15503
[Presentation] 胃癌腹膜播種患者における腹腔内免疫細胞の解析2024
- Author(s)
  松宮美沙希, 高橋礼, 金子勇貴, 風當ゆりえ, 髙橋和也, 松本志郎, 宮戸秀世, 倉科憲太郎, 齋藤心, 大澤英之, 山口博紀, 細谷好則, 佐田尚宏,北山丈二．
- Organizer
  第96回日本胃癌学会総会
- Data Source
  KAKENHI-PROJECT-23K08117
[Presentation] メトホルミン内服が治癒切除を受けた膵癌の予後に与える影響2024
- Author(s)
  高橋礼; 齋藤晶; 森嶋計; 笹沼英紀; 山口博紀; 佐久間康成; 川平洋; 堀江久永; 細谷好則; 味村俊樹; 北山丈二; 佐田尚宏.
- Organizer
  第57回日本成人病（生活習慣病）学会学術集会
- Data Source
  KAKENHI-PROJECT-23K15503
[Presentation] ２型糖尿病を伴う大腸癌の腫瘍免疫微小環境（TIME）に対するメトホルミンの効果2024
- Author(s)
  齋藤晶; 大澤英之; 松宮美沙希; 高橋礼; 宮戸秀世; 佐田尚宏; 山口博紀; 北山丈二.
- Organizer
  第45回癌免疫外科研究会
- Data Source
  KAKENHI-PROJECT-23K15503
[Presentation] The enhanced formation of neutrophil extracellular traps (NETs) may contribute to the exacerbation of peritoneal metastasisi in a diabetic host.2024
- Author(s)
  R. Takahashi; H. Ohzawa; Y. Kaneko; M. Matsumiya; Y. Futoh; K. Tamura; K. Takahashi; Y. Kimura; A. Saito; H. Miyato; N. Sata; J. Kitayama.
- Organizer
  American Association for Cancer Research 2024
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-23K15503
[Presentation] Intraperitoneal Paclitaxel chemotherapy luduces eosinophil recruitment to the peritoneal cavity: Implications in gastric cancer peritoneal metastasis.2024
- Author(s)
  Misaki Matsumiya; Kazuya Takahashi; Hideyo Miyato; Kentaro Kurashina; Shin Saito; Hideyuki Ohzawa; Hironori Yamaguchi; Yoshinori Hosoya; Naohiro Sata; J. Kitayama.
- Organizer
  14th International Congress peritoneal surface malignancies
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-23K08117
[Presentation] 胃癌の腹膜転移（PM）におけるクローディン18.2の発現2024
- Author(s)
  齋藤晶; 大澤英之; 松宮美沙希; 川嶋理恵; 髙橋和也; 松本志郎; 倉科憲太郎; 宮戸秀世; 齋藤心; 細谷好則; 佐田尚宏; 山口博紀; 北山丈二.
- Organizer
  第62回日本癌治療学会学術集会
- Data Source
  KAKENHI-PROJECT-24K11874
[Presentation] 腹腔内化学療法に伴う腹腔内好酸球の動態と治療効果の相関性2024
- Author(s)
  松宮美沙希; 水津枝理; 高橋礼; 高橋和也; 松本志郎; 園田洋史; 宮戸秀世; 倉科憲太郎; 齋藤心; 大澤英之; 山口博紀; 細谷好則; 佐田尚宏; 北山丈二.
- Organizer
  第62回日本癌治療学会学術集会
- Data Source
  KAKENHI-PROJECT-23K08117
[Presentation] 胃癌腹膜播種患者における腹腔内免疫細胞の解析2024
- Author(s)
  松宮美沙希; 高橋礼; 金子勇貴; 風當ゆりえ; 髙橋和也; 松本志郎; 宮戸秀世; 倉科憲太郎; 齋藤心; 大澤英之; 山口博紀; 細谷好則; 佐田尚宏; 北山丈二.
- Organizer
  第96回日本胃癌学会総会
- Data Source
  KAKENHI-PROJECT-23K08117
[Presentation] Flow cytometric analysis of intraperitoneal tumor and immune cells of the gastric cancer patients2023
- Author(s)
  Kazuya Takahashi, Hideyuki Ohzawa, Rihito Kanamaru, Shiro Matsumoto, Kentaro Kurashina, Shin Saito, Hironori Yamaguchi, Yoshinori Hosoya, Naohiro Sata,Joji Kitayama.
- Organizer
  Advanced Caner Therapies 2023 (SSO)
- Data Source
  KAKENHI-PROJECT-23K08117
[Presentation] The effect of Metformin on neutrophil extracellular traps (NETs) and effector T cells in tumor immune microenvironment (TIME) of colorectal cancer with type 2 diabetes mellitus2023
- Author(s)
  Akira Saito, Hideyuki Ohzawa, Yuki Kaneko, Kohei Tamura, Yurie Futoh, Kazuya Takahashi, Yuki Kimura, Rie Kawashima, Hideyo Miyato, Naohiro Sata, Joji Kitayama
- Organizer
  American Association for Cancer Research
- Data Source
  KAKENHI-PROJECT-23K15503
[Presentation] 胃癌腹膜播種に対する腹腔内化学療法における腹腔内好酸球の意義2023
- Author(s)
  髙橋和也, 松宮美沙希, 金子勇貴, 山口博紀, 倉科憲太郎, 松本志郎, 齋藤心, 細谷好則, 佐田尚宏,北山丈二．
- Organizer
  第61回日本癌治療学会学術集会
- Data Source
  KAKENHI-PROJECT-23K08117
[Presentation] 抗糖尿病薬メトホルミンは大腸癌組織内好中球を介して患者予後を改善する2023
- Author(s)
  齋藤晶、大澤英之、松宮美沙希、高橋礼、田村昂平、金子勇貴、風當ゆりえ、髙橋和也、木村有希、宮戸秀世、佐田尚宏、北山丈二
- Organizer
  第56回日本成人病（生活習慣病）学会
- Data Source
  KAKENHI-PROJECT-23K15503
[Presentation] Intraperitoneal immune microenvironment in patients with peritoneal metastasis in gastric cancer　胃癌腹膜播種における腹腔内免疫環境について2023
- Author(s)
  髙橋和也, 大澤英之, 金丸理人, 松本志郎, 倉科憲太郎, 齋藤心, 山口博紀, 細谷好則, 佐田尚宏,北山丈二．
- Organizer
  第95回日本胃癌学会総会
- Data Source
  KAKENHI-PROJECT-23K08117

1. 大澤英之 (60458271)

# of Collaborated Projects: 3 results

# of Collaborated Products: 9 results
2. 北山丈二 (20251308)

# of Collaborated Projects: 3 results

# of Collaborated Products: 12 results
3. 宮戸秀世 (90813163)

# of Collaborated Projects: 2 results

# of Collaborated Products: 2 results
4. 山口博紀 (20376445)

# of Collaborated Projects: 2 results

# of Collaborated Products: 11 results
5. 倉科憲太郎 (70382900)

# of Collaborated Projects: 1 results

# of Collaborated Products: 9 results
6. 大本理恵 (10814444)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
7. 野口忠秀 (30275705)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
8. 相澤健一 (70436484)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
9. 佐田尚宏

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
10. 綿野亮太

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
11. 水上浩明

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
12. 齋藤心

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
13. 高橋和也

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Saito Akira 齋藤 晶

Research Projects

Research Products

Co-Researchers

Efficacy of anti-Claudin18.2 antibody for gastric cancer peritoneal dissemination

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Elucidation of neutrophil dynamics and its clinical significance in diabetic cancerPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Development of therapy of peritoneal dissemination using novel nucleic acid drugs and extracellular vesicles

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Intraperitoneal immune microenvironment in patients with peritoneal dissemination and its therapeutic application

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

30色多重免疫染色定量解析法を用いたOPMDs・口腔癌の腫瘍微小環境の解明

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

[Journal Article] Expression of Claudin18.2 in metastatic lesions in peritoneum of gastric cancer2025

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Metformin Alters Tumor Immune Microenvironment, Improving the Outcomes of Breast Cancer Patients With Type 2 Diabetes Mellitus.2024

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Intraperitoneal administration of adeno-associated virus encoding microRNA-29b for the treatment of peritoneal metastasis2024

Author(s)

Journal Title

DOI

Data Source

[Journal Article] 特集 進行消化器癌に対するconversion surgeryのすべて II. 各論 2. 胃 2)胃癌腹膜播種に対する外科治療戦略2023

Author(s)

Journal Title

DOI

ISSN

Year and Date

Data Source

[Journal Article] Metformin may improve the outcome of patients with colorectal cancer and type 2 diabetes mellitus partly through effects on neutrophil extracellular traps.2023

Author(s)

Journal Title

DOI

Data Source

[Presentation] 腹腔内化学療法に伴う腹腔内好酸球の動態と治療効果との相関性2025

Author(s)

Organizer

Data Source

[Presentation] メトホルミンは腫瘍の微小環境を修飾し、浸潤性膵管癌の予後を改善する2025

Author(s)

Organizer

Data Source

[Presentation] メトホルミン内服が根治切除を受けた浸潤性膵管癌の予後に与える影響2024

Author(s)

Organizer

Data Source

[Presentation] 治癒切除を受けた膵癌患者の予後に与える抗糖尿病薬の影響2024

Author(s)

Organizer

Data Source

[Presentation] 糖尿病における好中球細胞外トラップ形成の亢進は胃癌腹膜播種を促進する2024

Author(s)

Organizer

Saito Akira 齋藤晶

[Journal Article] 特集進行消化器癌に対するconversion surgeryのすべて II. 各論 2. 胃 2)胃癌腹膜播種に対する外科治療戦略2023

[Presentation] Intraperitoneal immune microenvironment in patients with peritoneal metastasis in gastric cancer　胃癌腹膜播種における腹腔内免疫環境について2023