Minakawa Eiko 皆川栄子

Researcher Number	20726252
Other IDs
Affiliation (Current)	2026: 国立研究開発法人国立精神・神経医療研究センター, 神経研究所モデル動物開発研究部, 特任室長
Affiliation (based on the past Project Information) *help	2021 – 2025: 国立研究開発法人国立精神・神経医療研究センター, 神経研究所モデル動物開発研究部, 特任室長 2024: 国立研究開発法人国立精神・神経医療研究センター, 神経研究所モデル動物開発研究部, 特任研究室長 2020 – 2021: 国立研究開発法人国立精神・神経医療研究センター, 神経研究所モデル動物開発研究部, 客員研究員 2019 – 2020: 国立研究開発法人国立精神・神経医療研究センター, 神経研究所疾病研究第四部, リサーチフェロー 2018 – 2019: 国立研究開発法人国立精神・神経医療研究センター, 神経研究所疾病研究第四部, 流動研究員 … More 2016: 国立研究開発法人国立精神・神経医療研究センター, 神経研究所疾病研究第四部, 流動研究員 2015: 国立研究開発法人国立精神・神経医療研究センター, 神経研究所疾病研究第四部, 科研費研究員 2014: 独立行政法人国立精神・神経医療研究センター, 神経研究所疾病研究第四部, 科研費研究員 Less
Review Section/Research Field	Principal Investigator Basic Section 59040:Nutrition science and health science-related / Basic Section 52020:Neurology-related / Neurology Except Principal Investigator Basic Section 47060:Clinical pharmacy-related / Basic Section 52040:Radiological sciences-related / Medium-sized Section 63:Environmental analyses and evaluation and related fields
Keywords	Principal Investigator 認知症 / 神経変性疾患 / 睡眠 / 睡眠の質 / 中途覚醒 / 混合病理 / バイオマーカー / 多臓器円環 / α-シヌクレイン / パーキンソン病 / アルツハイマー病 / 睡眠障害 … More Except Principal Investigator … More 神経変性疾患 / クリアランス / エクソソーム / ストレス顆粒 / ストレス応答 / タンパク質凝集 / 早期診断 / マルチバレント / アルツハイマー病 / PET / 環境要因 / 環境因子 / バイオマーカー / プロテオスターシス / トランスレーショナルリサーチ / トランスレーショナル・リサーチ / 環境脳科学 / 環境医科学 Less

ストレス応答の回復過程におけるストレス顆粒クリアランス機構の解明と病的意義
- Principal Investigator
  
  武内敏秀
- Project Period (FY)
  2025 – 2027
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 47060:Clinical pharmacy-related
- Research Institution
  Kindai University
認知症の混合病理進展プロセスに対する睡眠の寄与の解明Principal Investigator
- Principal Investigator
  
  皆川栄子
- Project Period (FY)
  2024 – 2026
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 59040:Nutrition science and health science-related
- Research Institution
  National Center of Neurology and Psychiatry
Development of multivalent PET tracers for the early diagnosis of Alzheimer's disease
- Principal Investigator
  
  加藤孝一
- Project Period (FY)
  2024 – 2026
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 52040:Radiological sciences-related
- Research Institution
  National Center of Neurology and Psychiatry
エクソソームによるタンパク質クリアランス機構の解明と病的意義
- Principal Investigator
  
  武内敏秀
- Project Period (FY)
  2024 – 2025
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 47060:Clinical pharmacy-related
- Research Institution
  Kindai University
Identification of molecular biomarkers as indicators of changes in multi-organ crosstalk caused by impaired sleep qualityPrincipal Investigator
- Principal Investigator
  
  Minakawa Eiko
- Project Period (FY)
  2021 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 59040:Nutrition science and health science-related
- Research Institution
  National Center of Neurology and Psychiatry
Relationships between age-related cognitive decline and developmental exposure to dioxins
- Principal Investigator
  
  KAKEYAMA Masaki
- Project Period (FY)
  2019 – 2021
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Review Section
  
  Medium-sized Section 63:Environmental analyses and evaluation and related fields
- Research Institution
  Waseda University
Regulating the pathogenesis of Parkinson's disease through improvement of sleep qualityPrincipal Investigator
- Principal Investigator
  
  Minakawa Eiko
- Project Period (FY)
  2018 – 2020
- Research Category
  
  Grant-in-Aid for Early-Career Scientists
- Review Section
  
  Basic Section 52020:Neurology-related
- Research Institution
  National Center of Neurology and Psychiatry
Development of diagnostic biomarkers for neurodegenerative diseases by comprehensive analysis of disease-associated alterations in organismal proteostasis
- Principal Investigator
  
  Takeuchi Toshihide
- Project Period (FY)
  2018 – 2020
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 47060:Clinical pharmacy-related
- Research Institution
  Kindai University
  Osaka University
Toward understanding the mechanism that mediates the bidirectional relationship between sleep disturbance and neurodegenerationPrincipal Investigator
- Principal Investigator
  
  Minakawa Eiko
- Project Period (FY)
  2014 – 2016
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Neurology
- Research Institution
  National Center of Neurology and Psychiatry

All 2024 2023 2021 2020 2017 2015

All Journal Article Presentation

[Journal Article] Dysregulation of stress granule dynamics by DCTN1 deficiency exacerbates TDP-43 pathology in Drosophila models of ALS/FTD.2024
- Author(s)
  Ueda T, Takeuchi T, Fujikake N, Suzuki M, Minakawa EN, Ueyama M, Fujino Y, Kimura N, Nagano S, Yokoseki A, Onodera O, Mochizuki H, Mizuno T, Wada K, Nagai Y.
- Journal Title
  
  Acta Neuropathol Commun
  
  Volume: 12 Issue: 1 Pages: 20-20
- DOI
  10.1186/s40478-024-01729-8
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-23K18265, KAKENHI-PROJECT-22K19762, KAKENHI-PROJECT-21H02841, KAKENHI-PUBLICLY-22H04811, KAKENHI-PROJECT-21H02840, KAKENHI-PLANNED-20H05927, KAKENHI-PROJECT-23K24054
[Journal Article] Sustained therapeutic benefits by transient reduction of TDP-43 using ENA-modified antisense oligonucleotides in ALS/FTD mice.2023
- Author(s)
  Takeuchi T., Maeta K., Xin D., Oe Y., Takeda A., Inoue M., Nagano S., Fujihara T., Matsuda S., Ishigaki S., Sahashi K., Minakawa E.N., Mochizuki H., Neya M., Sobue G., *Nagai Y.
- Journal Title
  
  Mol. Ther. Nucleic Acids
  
  Volume: 31 Pages: 353-366
- DOI
  10.1016/j.omtn.2023.01.006
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-21H02840, KAKENHI-PROJECT-23K18265, KAKENHI-PLANNED-20H05927, KAKENHI-PROJECT-21H02841, KAKENHI-PUBLICLY-22H04811, KAKENHI-PROJECT-21K07762, KAKENHI-PROJECT-23K21410, KAKENHI-PROJECT-23K24054
[Journal Article] Drug Development for Neurodegenerative Diseases2015
- Author(s)
  Yoshitaka Nagai and Eiko N. Minakawa
- Journal Title
  
  Neurodegenerative Disorders as Systemic Diseases (Springer Publishers, Inc., Ed. Keiji Wada)
  
  Volume: N/A Pages: 183-216
- DOI
  10.1007/978-4-431-54541-5_9
- ISBN
  9784431545408, 9784431545415
- Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-26860681
[Presentation] Young 5XFAD mice recapitulate preclinical Alzheimer's disease biomarkers in cerebrospinal fluid and plasma2024
- Author(s)
  Hiroko Yagihara, Toshihide Takeuchi, Yuko Saito, Eiko N. Minakawa, Kazuhiko Seki
- Organizer
  NEURO2024
- Data Source
  KAKENHI-PROJECT-23K24054
[Presentation] Blood biomarker development for polyglutamine diseases using marmoset models2024
- Author(s)
  Toshihide Takeuchi, Eiko N. Minakawa, Kohji Ueda, Yuji Takahashi, Kazuhiko Seki, Yoshitaka Nagai
- Organizer
  第13回日本マーモセット研究会
- Data Source
  KAKENHI-PROJECT-23K24054
[Presentation] Young 5XFAD mice recapitulate the biofluid biomarker changes of preclinical Alzheimer’s disease2024
- Author(s)
  Hiroko Yagihara, Toshihide Takeuchi, Yuko Saito, Eiko N. Minakawa, Kazuhiko Seki
- Organizer
  第65回日本神経学会学術大会／第19回アジア・オセアニア神経学会議（AOCN2024）
- Data Source
  KAKENHI-PROJECT-23K24054
[Presentation] TDP-43を標的とした核酸医薬はALS/FTDマウスに対して持続的な治療効果を発揮する2023
- Author(s)
  武内敏秀、前田和宏、Ding Xin、大江由佳子、武田明子、長野清一、藤原健志、松田誠司、石垣診祐、佐橋健太郎、皆川栄子、望月秀樹、閨正博、祖父江元、永井義隆
- Organizer
  第42回日本認知症学会
- Data Source
  KAKENHI-PROJECT-23K24054
[Presentation] Sustained therapeutic benefits by transient reduction of TDP-43 using ENA-modified antisense oligonucleotides in ALS/FTD mice2023
- Author(s)
  Toshihide Takeuchi, Kazuhiro Maeta, Ding Xin, Yukako Oe, Akiko Takeda, Mana Inoue, Seiichi Nagano, Tsuyoshi Fujihara, Seiji Matsuda, Shinsuke Ishigaki, Kentaro Sahashi, Eiko N. Minakawa, Hideki Mochizuki, Masahiro Neya, Gen Sobue, Yoshitaka Nagai
- Organizer
  第46回日本神経科学大会
- Data Source
  KAKENHI-PROJECT-23K24054
[Presentation] Sustained therapeutic benefits by transient reduction of TDP-43 using ENA-modified ASOs in ALS mice2023
- Author(s)
  武内敏秀、前田和宏、Ding Xin、大江由佳子、武田明子、長野清一、藤原健志、松田誠司、石垣診祐、佐橋健太郎、皆川栄子、望月秀樹、閨正博、祖父江元、永井義隆
- Organizer
  日本神経学会第64回学術大会
- Data Source
  KAKENHI-PROJECT-23K24054
[Presentation] Extracellular vesicles as blood-based biomarkers for polyglutamine diseases2021
- Author(s)
  武内敏秀、皆川栄子、植田幸嗣、齊藤勇二、高橋祐二、関和彦、永井義隆
- Organizer
  第62回日本神経学会
- Data Source
  KAKENHI-PROJECT-18H02585
[Presentation] Age-related cognitive functions of App knock-in mice in IntelliCage　system2020
- Author(s)
  城宝大輔, 鈴木健, 藤原昌也, 皆川栄子, 斉藤貴志, 西道隆臣, 掛山正心
- Organizer
  第43回日本神経科学大会
- Data Source
  KAKENHI-PROJECT-19H01152
[Presentation] 中途覚醒の増加はアルツハイマー病モデルマウスのアミロイドβ病理を悪化させる2017
- Author(s)
  皆川栄子、宮崎歴、丸尾和司、八木原紘子、藤田寛美、和田圭司、永井義隆
- Organizer
  日本睡眠学会第42回定期学術集会
- Place of Presentation
  パシフィコ横浜（神奈川県横浜市）
- Year and Date
  2017-06-29
- Data Source
  KAKENHI-PROJECT-26860681
[Presentation] Chronic sleep fragmentation exacerbates amyloid β deposition in Alzheimer's disease2017
- Author(s)
  皆川栄子、宮崎歴、丸尾和司、八木原紘子、藤田寛美、和田圭司、永井義隆
- Organizer
  第40回日本神経科学大会
- Place of Presentation
  幕張メッセ（千葉県千葉市）
- Year and Date
  2017-07-20
- Data Source
  KAKENHI-PROJECT-26860681
[Presentation] 良質な睡眠による神経変性疾患の発症進展抑制の可能性2017
- Author(s)
  皆川栄子
- Organizer
  第39回日本生物学的精神医学会・第47回日本神経精神薬理学会合同年会
- Place of Presentation
  札幌コンベンションセンター（北海道札幌市）
- Year and Date
  2017-09-28
- Invited
- Data Source
  KAKENHI-PROJECT-26860681

1. Takeuchi Toshihide (70600120)

# of Collaborated Projects: 3 results

# of Collaborated Products: 7 results
2. KAKEYAMA Masaki (30353535)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
3. 浜田道昭 (00596538)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
4. 久保健一郎 (20348791)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
5. 前川文彦 (40382866)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
6. 鈴掛雅美 (20583751)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
7. 加藤孝一 (50382198)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
8. 佐々木要 (10611783)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
9. 熊本卓哉 (50292678)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
10. 原田龍一 (60735455)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
11. 長野清一

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
12. 永井義隆

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Minakawa Eiko 皆川 栄子

Research Projects

Research Products

Co-Researchers

ストレス応答の回復過程におけるストレス顆粒クリアランス機構の解明と病的意義

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

認知症の混合病理進展プロセスに対する睡眠の寄与の解明Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Development of multivalent PET tracers for the early diagnosis of Alzheimer's disease

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

エクソソームによるタンパク質クリアランス機構の解明と病的意義

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Identification of molecular biomarkers as indicators of changes in multi-organ crosstalk caused by impaired sleep qualityPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Relationships between age-related cognitive decline and developmental exposure to dioxins

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Regulating the pathogenesis of Parkinson's disease through improvement of sleep qualityPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Development of diagnostic biomarkers for neurodegenerative diseases by comprehensive analysis of disease-associated alterations in organismal proteostasis

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Toward understanding the mechanism that mediates the bidirectional relationship between sleep disturbance and neurodegenerationPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] Dysregulation of stress granule dynamics by DCTN1 deficiency exacerbates TDP-43 pathology in Drosophila models of ALS/FTD.2024

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Sustained therapeutic benefits by transient reduction of TDP-43 using ENA-modified antisense oligonucleotides in ALS/FTD mice.2023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Drug Development for Neurodegenerative Diseases2015

Author(s)

Journal Title

DOI

ISBN

Data Source

[Presentation] Young 5XFAD mice recapitulate preclinical Alzheimer's disease biomarkers in cerebrospinal fluid and plasma2024

Author(s)

Organizer

Data Source

[Presentation] Blood biomarker development for polyglutamine diseases using marmoset models2024

Author(s)

Minakawa Eiko 皆川栄子

[Presentation] Age-related cognitive functions of App knock-in mice in IntelliCage　system2020