Inoue Masanori 井上真紀

Researcher Number	20726913
Other IDs
Affiliation (Current)	2026: 大分大学, 医学部, 講師
Affiliation (based on the past Project Information) *help	2022 – 2025: 大分大学, 医学部, 講師 2020 – 2021: 大分大学, 医学部, 助教 2019: 大分大学, 医学部, 医員
Review Section/Research Field	Principal Investigator Basic Section 52050:Embryonic medicine and pediatrics-related Except Principal Investigator Basic Section 52050:Embryonic medicine and pediatrics-related / Basic Section 58070:Lifelong developmental nursing-related
Keywords	Principal Investigator 急性肝不全 / LARS1 / オートファジー / 乳児肝不全症候群1型 / ゼブラフィッシュ / 遺伝子改変動物 / マウス / CRISPR/Cas9 / マウスモデル / ゼブラフィッシュモデル … More / LARS1遺伝子 / 神経変性疾患 / RNA代謝 / 橋小脳低形成 / PKM2 / p53 / 神経細胞死 / tRNA fragment / 橋小脳低形成10型 … More Except Principal Investigator ゼブラフィッシュ / オートファジー / 難聴 / 遠位尿細管性アシドーシス / 早老症 / ハッチンソンギルフォード / 遠位尿細管アシドーシス / ゼブラフィッシュXLMTMモデル / ライトシート型超解像顕微鏡 / 生体ライブイメージング / 重度肝障害 / ＭＴＭ１遺伝子 / 疾患モデル動物 / イメージング解析 / 肝障害 / MTM1遺伝子 / X連鎖性ミオチュブラーミオパチー / 肝星細胞 / 胆管上皮細胞 / 類洞内皮細胞 / 炎症 / 網羅的遺伝子解析 / 小児 / 遺伝カウンセリング / 臨床的意義不明の変化 / 細胞内代謝 / 機能獲得型変異 / 解糖系 / スペルミジン / 免疫疲弊 / ポリアミン / SLE / PI3K/Aktシグナル / PIK3CD / pH / リソソーム / 遺伝子変異率 / MELAS / ミトコンドリア / 脳卒中様エピソード / ヘテロプラスミー / ミトコンドリア病 / mitochondrial disease Less

乳児肝不全症候群1型における炎症増悪機序と治療標的の解明Principal Investigator
- Principal Investigator
  
  井上真紀
- Project Period (FY)
  2025 – 2027
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 52050:Embryonic medicine and pediatrics-related
- Research Institution
  Oita University
臨床的意義不明の変化と判定された小児と保護者への遺伝カウンセリング体制の構築
- Principal Investigator
  
  小栗沙織
- Project Period (FY)
  2024 – 2027
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 58070:Lifelong developmental nursing-related
- Research Institution
  Oita University
ゼブラフィッシュatp6v1ba遺伝子変異による耳石形成障害と難聴の機序解明
- Principal Investigator
  
  池内真代
- Project Period (FY)
  2024 – 2026
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 52050:Embryonic medicine and pediatrics-related
- Research Institution
  Oita University
Environmental factors under autophagy regulation causing the development of Hutchinson-Gilford progeria syndrome
- Principal Investigator
  
  井原健二
- Project Period (FY)
  2024 – 2028
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 52050:Embryonic medicine and pediatrics-related
- Research Institution
  Oita University
X連鎖性ミオチュブラーミオパチーに合併する肝紫斑病の病態メカニズムの解明
- Principal Investigator
  
  清水誠之
- Project Period (FY)
  2023 – 2026
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 52050:Embryonic medicine and pediatrics-related
- Research Institution
  Oita University
Identification of Factors Associated with Severe Disease in Infancy and Fever-Triggered Exacerbations in Infantile Liver Failure Syndrome Type 1Principal Investigator
- Principal Investigator
  
  Masanori Inoue
- Project Period (FY)
  2022 – 2024
- Research Category
  
  Grant-in-Aid for Early-Career Scientists
- Review Section
  
  Basic Section 52050:Embryonic medicine and pediatrics-related
- Research Institution
  Oita University
Elucidation of the mechanism of hearing loss associated with distal tubular acidosis
- Principal Investigator
  
  Ikeuchi Mayo
- Project Period (FY)
  2021 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 52050:Embryonic medicine and pediatrics-related
- Research Institution
  Oita University
Elucidation of the mechanism of SLE onset caused by novel PIK3CD gene mutations
- Principal Investigator
  
  Kiyota Kyoko
- Project Period (FY)
  2021 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 52050:Embryonic medicine and pediatrics-related
- Research Institution
  Oita University
Mitochondria function analysis using autopsied brain samples of MELAS
- Principal Investigator
  
  Miyahara Hiroaki
- Project Period (FY)
  2020 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 52050:Embryonic medicine and pediatrics-related
- Research Institution
  Aichi Medical University
Physiological and pathological significance of tRNA fragments in hereditary neurodegenerative diseasesPrincipal Investigator
- Principal Investigator
  
  Inoue Masanori
- Project Period (FY)
  2019 – 2021
- Research Category
  
  Grant-in-Aid for Early-Career Scientists
- Review Section
  
  Basic Section 52050:Embryonic medicine and pediatrics-related
- Research Institution
  Oita University

All 2025 2024 2023 2022 2020 2019

All Journal Article Presentation

[Journal Article] Cardiac manifestations of human ACTA2 variants recapitulated in a zebrafish model2024
- Author(s)
  Sebastian Wulan Apridita、Inoue Masanori、Shimizu Nobuyuki、Sato Ryosuke、Oguri Saori、Itonaga Tomoyo、Kishimoto Shintaro、Shiraishi Hiroshi、Hanada Toshikatsu、Ihara Kenji
- Journal Title
  
  Journal of Human Genetics
  
  Volume: 69 Issue: 3-4 Pages: 133-138
- DOI
  10.1038/s10038-024-01221-0
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-23K07336, KAKENHI-PROJECT-20H03644, KAKENHI-PROJECT-24K10095, KAKENHI-PROJECT-24K18891
[Journal Article] Biallelic variants in LARS1 induce steatosis in developing zebrafish liver via enhanced autophagy2024
- Author(s)
  Inoue Masanori、Sebastian Wulan Apridita、Sonoda Shota、Miyahara Hiroaki、Shimizu Nobuyuki、Shiraishi Hiroshi、Maeda Miwako、Yanagi Kumiko、Kaname Tadashi、Hanada Reiko、Hanada Toshikatsu、Ihara Kenji
- Journal Title
  
  Orphanet Journal of Rare Diseases
  
  Volume: 19 Issue: 1 Pages: 219-219
- DOI
  10.1186/s13023-024-03226-6
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-22K15947, KAKENHI-PROJECT-23K21629, KAKENHI-PROJECT-23K07336, KAKENHI-PROJECT-24K10095, KAKENHI-PROJECT-24KF0066
[Journal Article] A pH imbalance is linked to autophagic dysregulation of inner ear hair cells in Atp6v1ba-deficient zebrafish2024
- Author(s)
  Ikeuchi Mayo、Inoue Masanori、Miyahara Hiroaki、Sebastian Wulan Apridita、Miyazaki Shuya、Takeno Takashi、Kiyota Kyoko、Yano Shinji、Shiraishi Hiroshi、Shimizu Nobuyuki、Hanada Reiko、Yoshimura Akihiko、Ihara Kenji、Hanada Toshikatsu
- Journal Title
  
  Biochemical and Biophysical Research Communications
  
  Volume: 699 Pages: 149551-149551
- DOI
  10.1016/j.bbrc.2024.149551
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-23K07336, KAKENHI-PROJECT-21K06871, KAKENHI-PROJECT-21K07756, KAKENHI-PROJECT-20H03644, KAKENHI-PROJECT-23K21629, KAKENHI-PROJECT-24K10095
[Journal Article] Neuropathological hallmarks in autopsied cases with mitochondrial diseases caused by the mitochondrial 3243A>G mutation2023
- Author(s)
  Hiroaki Miyahara
- Journal Title
  
  Brain Pathology
  
  Volume: 33 Issue: 6
- DOI
  10.1111/bpa.13199
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K08196
[Journal Article] Tyrosine pre-transfer RNA fragments are linked to p53-dependent neuronal cell death via PKM22020
- Author(s)
  Inoue Masanori、Hada Kazumasa、Shiraishi Hiroshi、Yatsuka Hiroyuki、Fujinami Hiroyuki、Morisaki Ikuko、Nishida Yoshihiro、Matsubara Etsuro、Ishitani Tohru、Hanada Reiko、Matsumoto Masaki、Penninger Josef M.、Ihara Kenji、Hanada Toshikatsu
- Journal Title
  
  Biochemical and Biophysical Research Communications
  
  Volume: May 3 Issue: 3 Pages: 155-163
- DOI
  10.1016/j.bbrc.2020.02.157
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K22973, KAKENHI-PROJECT-19K17366, KAKENHI-PUBLICLY-19H04969, KAKENHI-PUBLICLY-19H05243, KAKENHI-PROJECT-16H05154, KAKENHI-PROJECT-19H03566, KAKENHI-PROJECT-16K11096, KAKENHI-PROJECT-17K19919, KAKENHI-PROJECT-18K19522, KAKENHI-PROJECT-17K15623, KAKENHI-PROJECT-20K21502, KAKENHI-PROJECT-19H03412, KAKENHI-PROJECT-20H03644, KAKENHI-PROJECT-18K06963, KAKENHI-PROJECT-18K08522, KAKENHI-PLANNED-20H05930
[Presentation] Multifactorial Mechanisms of Hepatic Peliosis in X-linked Myotubular Myopathy2025
- Author(s)
  Nobuyuki Shimizu, Hiroshi Shiraishi, Adiana Witaningrum Mutamsari, Masanori Inoue, Kyoko Kiyota, Kenji Ihara, Toshikatsu Hanada
- Organizer
  APPW2025（Anatomy-Physiology-Pharmacology Week in 2025）
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-23K07336
[Presentation] Lars1遺伝子改変マウスを用いた乳児肝不全症候群1型における感染症患罹時の重症化メカニズムの解明2024
- Author(s)
  甲斐絢音, 井上真紀, Wulan Apridita Sebastian, 宮原弘明, 前田美和子, 花田礼子, 花田俊勝, 井原健二
- Organizer
  第77回九州小児科学会
- Data Source
  KAKENHI-PROJECT-22K15947
[Presentation] X連鎖性ミオチュブラーミオパチーに伴う重度肝障害の病態メカニズム2024
- Author(s)
  清水誠之, 白石裕士, 井上真紀, 清田今日子, 井原健二, 花田俊勝
- Organizer
  第101回日本生理学会大会
- Data Source
  KAKENHI-PROJECT-23K07336
[Presentation] ヒト希少疾患の病態理解を加速させる魚類モデル2024
- Author(s)
  清水誠之, 白石裕士, 井上真紀, 清田今日子, 井原健二, 花田俊勝
- Organizer
  第97回日本生化学会大会シンポジウム
- Invited
- Data Source
  KAKENHI-PROJECT-23K07336
[Presentation] Elucidating characteristic phenotypes of leucyl-tRNA synthetase (LARS) deficiency unveiled via knock-in zebrafish2024
- Author(s)
  井原健二, 井上真紀, 前田美和子, Wulan Apridita Sebastian, 清水誠之, 白石裕士, 花田礼子, 花田俊勝
- Organizer
  第97回日本内分泌学会学術総会
- Data Source
  KAKENHI-PROJECT-22K15947
[Presentation] 生体イメージングから迫る先天性ミオパチーの肝障害メカニズム2024
- Author(s)
  清水誠之, 白石裕士, 井上真紀, 清田今日子, 井原健二, 花田俊勝
- Organizer
  第14回癌・炎症と抗酸化研究会（CIA研究会）
- Data Source
  KAKENHI-PROJECT-23K07336
[Presentation] 遺伝子改変ゼブラフィッシュを用いた希少遺伝性疾患の分子病態の解明と治療法の開発2024
- Author(s)
  井上真紀, Wulan Apridita Sebastia, 前田美和子, 清水誠之, 白石裕士, 花田礼子, 花田俊勝, 井原健二
- Organizer
  第1回九州・沖縄オープンユニバーシティ若手研究者交流ワークショップ
- Data Source
  KAKENHI-PROJECT-22K15947
[Presentation] ミオチュブラリン機能不全がもたらす肝障害メカニズム2024
- Author(s)
  清水誠之, 白石裕士, Adiana Mutamsari Witaningrum, 清田今日子, 井上真紀, 花田礼子, 井原健二, 花田俊勝
- Organizer
  令和6年度日本生化学大会九州支部例会
- Data Source
  KAKENHI-PROJECT-23K07336
[Presentation] Uncovering the Pathogenesis of Hepatic Complications in X-linked Myotubular Myopathy2024
- Author(s)
  Nobuyuki Shimizu, Hiroshi Shiraishi, Masanori Inoue, Kyoko Kiyota, Kenji Ihara, Toshikatsu Hanada
- Organizer
  18th International Zebrafish Conference (IZFS)
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-23K07336
[Presentation] Autophagy enhancement induces steatosis in the developing liver of lars-knock-in zebrafish2023
- Author(s)
  Masanori Inoue, Wulan Apridita Sebastian, Hiroaki Miyahara, Nobuyuki Shimizu, Hiroshi Shiraishi, Miwako Maeda, Reiko Hanada, Toshikatsu Hanada, Kenji Ihara
- Organizer
  Human Genetics Asia 2023
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-22K15947
[Presentation] X連鎖性ミオチュブラーミオパチーに伴う重度肝障害の分子メカニズムの解明2023
- Author(s)
  清水誠之, 白石裕士, 井上真紀, 清田今日子, 井原健二, 花田俊勝
- Organizer
  第96回日本生化学会大会
- Data Source
  KAKENHI-PROJECT-23K07336
[Presentation] ゼブラフィッシュイメージングを用いたX連鎖性ミオチュブラーミオパチーに合併する重度肝障害の病態機構解明2023
- Author(s)
  清水誠之, 白石裕士, 井上真紀, 清田今日子, 井原健二, 花田俊勝
- Organizer
  第13回癌・炎症と抗酸化研究会プログラム（CIA研究会）
- Data Source
  KAKENHI-PROJECT-23K07336
[Presentation] Analysis of the liver damage mechanism in infantile liver failure syndrome type 1 using lars knock-in zebrafish.2022
- Author(s)
  Masanori Inoue, Kazuhito Sekiguchi, Hiroaki Miyahara, Shota Sonoda, Nobuyuki Shimizu, Hiroshi Shiraishi, Miwako Maeda, Reiko Hanada, Toshikatsu Hanada, Kenji Ihara
- Organizer
  日本人類遺伝学会第67回大会
- Data Source
  KAKENHI-PROJECT-22K15947
[Presentation] tRNA代謝異常によるp53依存的神経細胞死の分子機構解明2019
- Author(s)
  井上真紀, 波田一誠, 白石裕士, 石谷太, 松本雅記, 井原健二, 花田俊勝
- Organizer
  第92回日本生化学会大会
- Data Source
  KAKENHI-PROJECT-19K17366

1. Sebastian WulanApridita (60979540)

# of Collaborated Projects: 3 results

# of Collaborated Products: 0 results
2. Miyahara Hiroaki (00457615)

# of Collaborated Projects: 2 results

# of Collaborated Products: 1 results
3. Ikeuchi Mayo (80865668)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
4. Kiyota Kyoko (30774492)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
5. 井原健二 (80294932)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
6. 吉田眞理 (60288545)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
7. 岩崎靖 (60378172)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
8. 関口和人 (40437926)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
9. 小栗沙織 (00993106)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
10. 清水誠之 (30817143)

# of Collaborated Projects: 1 results

# of Collaborated Products: 10 results
11. 花田俊勝 (10363350)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
12. 松尾宗明 (20219398)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
13. 小崎里華 (50234745)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
14. 西田欣広

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
15. 井上尚実

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Inoue Masanori 井上 真紀

Research Projects

Research Products

Co-Researchers

乳児肝不全症候群1型における炎症増悪機序と治療標的の解明Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

臨床的意義不明の変化と判定された小児と保護者への遺伝カウンセリング体制の構築

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

ゼブラフィッシュatp6v1ba遺伝子変異による耳石形成障害と難聴の機序解明

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Environmental factors under autophagy regulation causing the development of Hutchinson-Gilford progeria syndrome

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

X連鎖性ミオチュブラーミオパチーに合併する肝紫斑病の病態メカニズムの解明

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Identification of Factors Associated with Severe Disease in Infancy and Fever-Triggered Exacerbations in Infantile Liver Failure Syndrome Type 1Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Elucidation of the mechanism of hearing loss associated with distal tubular acidosis

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Elucidation of the mechanism of SLE onset caused by novel PIK3CD gene mutations

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Mitochondria function analysis using autopsied brain samples of MELAS

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Physiological and pathological significance of tRNA fragments in hereditary neurodegenerative diseasesPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

[Journal Article] Cardiac manifestations of human ACTA2 variants recapitulated in a zebrafish model2024

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Biallelic variants in LARS1 induce steatosis in developing zebrafish liver via enhanced autophagy2024

Author(s)

Journal Title

DOI

Data Source

[Journal Article] A pH imbalance is linked to autophagic dysregulation of inner ear hair cells in Atp6v1ba-deficient zebrafish2024

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Neuropathological hallmarks in autopsied cases with mitochondrial diseases caused by the mitochondrial 3243A>G mutation2023

Inoue Masanori 井上真紀