Kuwabara Masanari 桑原政成

… Alternative Names

桑原政成クワバラマサナリ

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Researcher Number	20728290
Other IDs	https://orcid.org/0000-0002-6601-4347
Affiliation (Current)	2026: 自治医科大学, 医学部, 准教授
Affiliation (based on the past Project Information) *help	2026: 自治医科大学, 医学部, 准教授 2024: 自治医科大学, 医学部, 准教授 2023: (財)冲中記念成人病研究所, その他部局等, 研究員 2020 – 2021: (財)冲中記念成人病研究所, その他部局等, 研究員
Review Section/Research Field	Principal Investigator Basic Section 53020:Cardiology-related
Keywords	Principal Investigator 高尿酸血症 / 心血管疾患 / 尿酸 / 離脱症候群 / キサンチンオキシダーゼ阻害薬 / 認知症 / アデノシン三リン酸 / 疫学 / 死亡 / 併用薬

エネルギー代謝に着目した尿酸代謝薬等中止による離脱症候群の発症機序解明Principal Investigator
- Principal Investigator
  
  桑原政成
- Project Period (FY)
  2026 – 2028
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 53020:Cardiology-related
- Research Institution
  Jichi Medical University
Causes and Mechanisms of Xanthine Oxidase Inhibitor Withdrawal SyndromePrincipal Investigator
- Principal Investigator
  
  桑原政成
- Project Period (FY)
  2023 – 2025
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 53020:Cardiology-related
- Research Institution
  Jichi Medical University
  Okinaka Memorial Institute for Medical Research
A study on the mechanism of xanthine oxidase inhibitor withdrawal syndromePrincipal Investigator
- Principal Investigator
  
  Kuwabara Masanari
- Project Period (FY)
  2020 – 2021
- Research Category
  
  Grant-in-Aid for Early-Career Scientists
- Review Section
  
  Basic Section 53020:Cardiology-related
- Research Institution
  Okinaka Memorial Institute for Medical Research

All 2025 2024 2023 2022 2021

All Journal Article Presentation

[Journal Article] Hyperuricemia, A new cardiovascular risk2025
- Author(s)
  Kuwabara Masanari、Hisatome Ichiro、Ae Ryusuke、Kosami Koki、Aoki Yuhei、Andres-Hernando Ana、Kanbay Mehmet、Lanaspa Miguel A.
- Journal Title
  
  Nutrition, Metabolism and Cardiovascular Diseases
  
  Volume: 35 Issue: 3 Pages: 103796-103796
- DOI
  10.1016/j.numecd.2024.103796
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23K07493
[Journal Article] Prediction for Risk of Hypouricemia in Hospitalized Patients: A Single-center, Retrospective Cohort Study2025
- Author(s)
  Hisatome Ichiro、Tomita Katsuyuki、Kato Ryohei、Ikeuchi Tomoyuki、Touge Hirokazu、Hamada Toshihiro、Goto Tamotsu、Ninomiya Haruaki、Otani Naoyuki、Kuwabara Masanari、Miyazaki Satoshi、Yamasaki Akira
- Journal Title
  
  Internal Medicine
  
  Volume: 64 Issue: 7 Pages: 1009-1016
- DOI
  10.2169/internalmedicine.3517-24
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23K07493
[Journal Article] Colchicine and cardiovascular protection in gout: unresolved questions2025
- Author(s)
  Kuwabara Masanari、Ohtani Naoyuki、Hisatome Ichiro
- Journal Title
  
  The Lancet Rheumatology
  
  Volume: 7 Issue: 3 Pages: e160-e161
- DOI
  10.1016/s2665-9913(25)00024-4
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23K07493
[Journal Article] Current updates and future perspectives in uric acid research, 20242024
- Author(s)
  Kuwabara Masanari、Ae Ryusuke、Kosami Koki、Kanbay Mehmet、Andres-Hernando Ana、Hisatome Ichiro、Lanaspa Miguel A.
- Journal Title
  
  Hypertension Research
  
  Volume: 48 Issue: 2 Pages: 867-873
- DOI
  10.1038/s41440-024-02031-9
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23K07493
[Journal Article] Activation of AMPD2 drives metabolic dysregulation and liver disease in mice with hereditary fructose intolerance2024
- Author(s)
  Andres-Hernando Ana、Orlicky David J.、Kuwabara Masanari、Fini Mehdi A.、Tolan Dean R.、Johnson Richard J.、Lanaspa Miguel A.
- Journal Title
  
  Communications Biology
  
  Volume: 7 Issue: 1 Pages: 849-849
- DOI
  10.1038/s42003-024-06539-1
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-23K07493
[Journal Article] Annual change in eGFR in renal hypouricemia: a retrospective pilot study2024
- Author(s)
  Sugihara Shinobu、Yamamoto Yasutaka、Teramoto Kei、Hamada Toshiro、Miyazaki Satoshi、Ogino Kazuhide、Kuwabara Masanari、Ohtahara Akira、Mizuta Einosuke、Ichida Kimiyoshi、Endo Yusuke、Minato Hiroyuki、Ninomiya Haruaki、Kato Masahiko、Yamamoto Kazuhiro、Hisatome Ichiro
- Journal Title
  
  Clinical and Experimental Nephrology
  
  Volume: 29 Issue: 2 Pages: 173-181
- DOI
  10.1007/s10157-024-02558-8
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23K07493
[Journal Article] Xanthine oxidase inhibitors treatment or discontinuation effects on mortality: evidence of xanthine oxidase inhibitors withdrawal syndrome2024
- Author(s)
  Kuwabara Masanari、Nakai Michikazu、Sumita Yoko、Iwanaga Yoshitaka、Ae Ryusuke、Kodama Takahide、Hisatome Ichiro、Kamatani Naoyuki
- Journal Title
  
  Frontiers in Pharmacology
  
  Volume: 14 Pages: 1289386-1289386
- DOI
  10.3389/fphar.2023.1289386
- Data Source
  KAKENHI-PROJECT-23K07493
[Journal Article] Impact of Hyper- and Hypo-Uricemia on Kidney Function2023
- Author(s)
  Miake Junichiro、Hisatome Ichiro、Tomita Katsuyuki、Isoyama Tadahiro、Sugihara Shinobu、Kuwabara Masanari、Ogino Kazuhide、Ninomiya Haruaki
- Journal Title
  
  Biomedicines
  
  Volume: 11 Issue: 5 Pages: 1258-1258
- DOI
  10.3390/biomedicines11051258
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K20662, KAKENHI-PROJECT-23K07493, KAKENHI-PROJECT-23K10826
[Journal Article] Update in uric acid, hypertension, and cardiovascular diseases2023
- Author(s)
  Kuwabara Masanari、Kodama Takahide、Ae Ryusuke、Kanbay Mehmet、Andres-Hernando Ana、Borghi Claudio、Hisatome Ichiro、Lanaspa Miguel A.
- Journal Title
  
  Hypertension Research
  
  Volume: 46 Issue: 7 Pages: 1714-1726
- DOI
  10.1038/s41440-023-01273-3
- Data Source
  KAKENHI-PROJECT-23K07493
[Journal Article] Exploring the Multifaceted Nexus of Uric Acid and Health: A Review of Recent Studies on Diverse Diseases2023
- Author(s)
  Kuwabara Masanari、Fukuuchi Tomoko、Aoki Yuhei、Mizuta Einosuke、Ouchi Motoshi、Kurajoh Masafumi、Maruhashi Tatsuya、Tanaka Atsushi、Morikawa Nagisa、Nishimiya Kensuke、Akashi Naoyuki、Tanaka Yoshihiro、Otani Naoyuki、Morita Mihoko、et al.
- Journal Title
  
  Biomolecules
  
  Volume: 13 Issue: 10 Pages: 1519-1519
- DOI
  10.3390/biom13101519
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-22K15507, KAKENHI-PROJECT-22KK0152, KAKENHI-PROJECT-21K11581, KAKENHI-PROJECT-22K08146, KAKENHI-PROJECT-23K07493, KAKENHI-PROJECT-21K15293, KAKENHI-PROJECT-20H00568
[Journal Article] 2023 update and perspectives2023
- Author(s)
  Mogi Masaki、Tanaka Atsushi、Node Koichi、Tomitani Naoko、Kuwabara Masanari、et al.
- Journal Title
  
  Hypertension Research
  
  Volume: 47 Issue: 1 Pages: 6-32
- DOI
  10.1038/s41440-023-01398-5
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-23K07493, KAKENHI-PROJECT-23K09671, KAKENHI-PROJECT-23K24329
[Journal Article] Xanthinuria Type 1 with a Novel Mutation in Xanthine Dehydrogenase and a Normal Endothelial Function2022
- Author(s)
  Satoshi Miyazaki, hisatome I, et al
- Journal Title
  
  Intern. Med.
  
  Volume: 61 Issue: 9 Pages: 1383-1386
- DOI
  10.2169/internalmedicine.7897-21
- ISSN
  0918-2918, 1349-7235
- Year and Date
  2022-05-01
- Language
  English
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K08074, KAKENHI-PROJECT-20K17168, KAKENHI-PROJECT-21K11581, KAKENHI-PROJECT-17K11191
[Journal Article] Temporal trends in the prevalence and characteristics of hypouricaemia: a descriptive study of medical check-up and administrative claims data2022
- Author(s)
  Koto Ruriko、Sato Izumi、Kuwabara Masanari、Seki Tomotsugu、Kawakami Koji
- Journal Title
  
  Clinical Rheumatology
  
  Volume: in press Issue: 7 Pages: 2113-2119
- DOI
  10.1007/s10067-022-06071-9
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20K17168
[Journal Article] Kv1.5 channel mediates monosodium urate-induced activation of NLRP3 inflammasome in macrophages and arrhythmogenic effects of urate on cardiomyocytes2022
- Author(s)
  Peili Li, Yasutaka Kurata, Fikri Taufiq, et al
- Journal Title
  
  Molecular Biology Reports
  
  Volume: online ahead of print Issue: 7 Pages: 0-0
- DOI
  10.1007/s11033-022-07378-1
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K08074, KAKENHI-PROJECT-20K17168, KAKENHI-PROJECT-19K08557, KAKENHI-PROJECT-22K06979
[Journal Article] Association Between Kidney Function Decline and Baseline TNFR Levels or Change Ratio in TNFR by Febuxostat Chiefly in Non-diabetic CKD Patients With Asymptomatic Hyperuricemia2021
- Author(s)
  Gohda Tomohito、Yanagisawa Naotake、Murakoshi Maki、Ueda Seiji、Nishizaki Yuji、Nojiri Shuko、Ohashi Yasuo、Ohno Iwao、Shibagaki Yugo、Imai Naohiko、Iimuro Satoshi、Kuwabara Masanari、Hayakawa Hiroshi、Kimura Kenjiro、Hosoya Tatsuo、Suzuki Yusuke
- Journal Title
  
  Frontiers in Medicine
  
  Volume: 8 Pages: 634932-634932
- DOI
  10.3389/fmed.2021.634932
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K17168, KAKENHI-PROJECT-20K08617
[Journal Article] Therapeutic Strategies for the Treatment of Chronic Hyperuricemia: An Evidence-Based Update2021
- Author(s)
  Cicero Arrigo F. G.、Fogacci Federica、Kuwabara Masanari、Borghi Claudio
- Journal Title
  
  Medicina
  
  Volume: 57 Issue: 1 Pages: 58-58
- DOI
  10.3390/medicina57010058
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K17168
[Journal Article] The Role of Uric Acid in the Acute Myocardial Infarction: A Narrative Review2021
- Author(s)
  Demiray Atalay、Afsar Baris、Covic Adrian、Kuwabara Masanari、Ferro Charles J.、Lanaspa Miguel A.、Johnson Richard J.、Kanbay Mehmet
- Journal Title
  
  Angiology
  
  Volume: 73 Issue: 1 Pages: 9-17
- DOI
  10.1177/00033197211012546
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K17168
[Journal Article] Umami-induced obesity and metabolic syndrome is mediated by nucleotide degradation and uric acid generation2021
- Author(s)
  Andres-Hernando Ana、Cicerchi Christina、Kuwabara Masanari、Orlicky David J.、Sanchez-Lozada Laura Gabriela、Nakagawa Takahiko、Johnson Richard J.、Lanaspa Miguel A.
- Journal Title
  
  Nature Metabolism
  
  Volume: 3 Issue: 9 Pages: 1189-1201
- DOI
  10.1038/s42255-021-00454-z
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20K17168
[Journal Article] Uric Acid as a Risk Factor for Chronic Kidney Disease and Cardiovascular Disease　― Japanese Guideline on the Management of Asymptomatic Hyperuricemia ―2021
- Author(s)
  Hisatome Ichiro、Li Peili、Miake Junichiro、Taufiq Fikri、Mahati Endang、Maharani Nani、Utami Sulistiyati Bayu、Kuwabara Masanari、Bahrudin Udin、Ninomiya Haruaki
- Journal Title
  
  Circ J
  
  Volume: 85 Issue: 2 Pages: 130-138
- DOI
  10.1253/circj.CJ-20-0406
- NAID
  130007975319
- ISSN
  1346-9843, 1347-4820
- Year and Date
  2021-01-25
- Language
  English
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K20662, KAKENHI-PROJECT-18K08074, KAKENHI-PROJECT-20K17168
[Journal Article] Factors Influencing Change in Serum Uric Acid After Administration of the Sodium‐Glucose Cotransporter 2 Inhibitor Luseogliflozin in Patients With Type 2 Diabetes Mellitus2021
- Author(s)
  Chino Yukihiro、Kuwabara Masanari、Hisatome Ichiro
- Journal Title
  
  The Journal of Clinical Pharmacology
  
  Volume: 62 Issue: 3 Pages: 366-375
- DOI
  10.1002/jcph.1970
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20K17168
[Journal Article] Serum Urate Trajectory in Young Adulthood and Incident Cardiovascular Disease Events by Middle Age: CARDIA Study2021
- Author(s)
  Morikawa Nagisa、Bancks Michael P.、Yano Yuichiro、Kuwabara Masanari、Gaffo Angelo L.、Duprez Daniel A.、Gross Myron D.、Jacobs David R.
- Journal Title
  
  Hypertension
  
  Volume: 78 Issue: 5 Pages: 1211-1218
- DOI
  10.1161/hypertensionaha.121.17555
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K17168
[Presentation] 教育セッション III-２循環器疾患における尿酸の意義を考える心血管疾患と尿酸－高血圧から心房細動まで－2025
- Author(s)
  桑原政成
- Organizer
  第89回日本循環器学会学術集会
- Invited
- Data Source
  KAKENHI-PROJECT-23K07493
[Presentation] PL Exploring Cardiac Energy Metabolism for Innovative Heart Failure Therapies Effects of Xanthine Oxidase Inhibitors (XOI) on ATP Storage and XOI Withdrawal Syndrome2025
- Author(s)
  Masanari Kuwabara
- Organizer
  第89回日本循環器学会学術集会
- Data Source
  KAKENHI-PROJECT-23K07493
[Presentation] 尿酸と肥満・糖尿病との密接な関係2025
- Author(s)
  桑原政成
- Organizer
  日本糖尿病学会第59回糖尿病学の進歩
- Invited
- Data Source
  KAKENHI-PROJECT-23K07493
[Presentation] 健診データを用いて運動と血清尿酸値との関係を明らかにする2025
- Author(s)
  上石知温、桑原政成、小佐見光樹、久留一郎、阿江竜介
- Organizer
  第58回日本痛風・尿酸核酸学会総会
- Data Source
  KAKENHI-PROJECT-23K07493
[Presentation] 高血圧管理・治療ガイドライン（JSH2025 ）における「高尿酸血症・痛風」管理指針2025
- Author(s)
  桑原政成
- Organizer
  第58回日本痛風・尿酸核酸学会総会
- Invited
- Data Source
  KAKENHI-PROJECT-23K07493
[Presentation] Xanthine oxidase inhibitor withdrawal syndrome2025
- Author(s)
  Masanari Kuwabara
- Organizer
  The EUREKA symposium, Jeju, Korea
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-23K07493
[Presentation] Merits of Controlling Serum Uric Acid Levels: Implications for Gout and Cardiovascular Health2025
- Author(s)
  Masanari Kuwabara
- Organizer
  China-Japan Academic Conference of Gout Treatment
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-23K07493
[Presentation] 心血管疾患と尿酸、尿酸生成抑制薬（キサンチンオキシダーゼ阻害薬）2024
- Author(s)
  桑原政成
- Organizer
  第45回日本臨床薬理学会学術集会
- Invited
- Data Source
  KAKENHI-PROJECT-23K07493
[Presentation] 尿酸と循環器病との関連2024
- Author(s)
  桑原政成
- Organizer
  第13回日本痛風・尿酸核酸学会教育研修会
- Invited
- Data Source
  KAKENHI-PROJECT-23K07493
[Presentation] 尿酸研究のアップデート2024
- Author(s)
  桑原政成
- Organizer
  第46回日本高血圧学会学術集会
- Invited
- Data Source
  KAKENHI-PROJECT-23K07493
[Presentation] 尿酸と心腎血管疾患との因果関係2024
- Author(s)
  桑原政成
- Organizer
  第46回日本高血圧学会学術集会
- Invited
- Data Source
  KAKENHI-PROJECT-23K07493
[Presentation] 痛風・尿酸核酸学会ジョイントシンポジウム高尿酸血症患者における降圧療法2024
- Author(s)
  桑原政成
- Organizer
  第46回日本高血圧学会学術集会
- Invited
- Data Source
  KAKENHI-PROJECT-23K07493
[Presentation] シンポジウム痛風・尿酸核酸領域のアップデート～最近の論文まとめ読み～2024
- Author(s)
  桑原政成
- Organizer
  第57回日本痛風・尿酸核酸学会
- Data Source
  KAKENHI-PROJECT-23K07493
[Presentation] Xanthine oxidase inhibitors withdrawal syndrome2023
- Author(s)
  Masanari. Kuwabara, Michikazu Nakai, Yoko Sumita, Takahide Kodama
- Organizer
  ESC (European Society of Cardiology) Congress 2023, Amsterdam, Netherlands
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-23K07493
[Presentation] シンポジウム高血圧の一成因としての高尿酸血症2023
- Author(s)
  桑原政成
- Organizer
  第45回日本高血圧学会
- Data Source
  KAKENHI-PROJECT-23K07493
[Presentation] 尿酸領域のアップデート2023
- Author(s)
  桑原政成
- Organizer
  第45回日本高血圧学会
- Data Source
  KAKENHI-PROJECT-23K07493
[Presentation] シンポジウム難治性高血圧の要因としてのフルクトース、尿酸の影響2023
- Author(s)
  桑原政成
- Organizer
  第71回日本心臓病学会
- Data Source
  KAKENHI-PROJECT-23K07493
[Presentation] シンポジウム　キサンチンオキシダーゼ阻害剤の有効性2022
- Author(s)
  桑原　政成
- Organizer
  第55回日本痛風・尿酸核酸学会総会
- Data Source
  KAKENHI-PROJECT-20K17168
[Presentation] シンポジウム「尿酸と腎update」高尿酸血症と心腎血管代謝疾患2021
- Author(s)
  桑原　政成
- Organizer
  第51回日本腎臓学会東部学術大会
- Data Source
  KAKENHI-PROJECT-20K17168
[Presentation] シンポジウム「循環器疾患予防のリスク管理の現状」高尿酸血症と心腎血管代謝疾患との関係2021
- Author(s)
  桑原　政成
- Organizer
  第69回日本心臓病学会学術集会
- Data Source
  KAKENHI-PROJECT-20K17168

1. 三明淳一朗

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
2. 森田美穂子

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
3. 李佩俐

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Kuwabara Masanari 桑原 政成

桑原 政成 クワバラ マサナリ

Research Projects

Research Products

Co-Researchers

エネルギー代謝に着目した尿酸代謝薬等中止による離脱症候群の発症機序解明Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Causes and Mechanisms of Xanthine Oxidase Inhibitor Withdrawal SyndromePrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

A study on the mechanism of xanthine oxidase inhibitor withdrawal syndromePrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

[Journal Article] Hyperuricemia, A new cardiovascular risk2025

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Prediction for Risk of Hypouricemia in Hospitalized Patients: A Single-center, Retrospective Cohort Study2025

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Colchicine and cardiovascular protection in gout: unresolved questions2025

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Current updates and future perspectives in uric acid research, 20242024

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Activation of AMPD2 drives metabolic dysregulation and liver disease in mice with hereditary fructose intolerance2024

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Annual change in eGFR in renal hypouricemia: a retrospective pilot study2024

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Xanthine oxidase inhibitors treatment or discontinuation effects on mortality: evidence of xanthine oxidase inhibitors withdrawal syndrome2024

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Impact of Hyper- and Hypo-Uricemia on Kidney Function2023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Update in uric acid, hypertension, and cardiovascular diseases2023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Exploring the Multifaceted Nexus of Uric Acid and Health: A Review of Recent Studies on Diverse Diseases2023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] 2023 update and perspectives2023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Xanthinuria Type 1 with a Novel Mutation in Xanthine Dehydrogenase and a Normal Endothelial Function2022

Author(s)

Kuwabara Masanari 桑原政成

桑原政成クワバラマサナリ

[Journal Article] Uric Acid as a Risk Factor for Chronic Kidney Disease and Cardiovascular Disease　― Japanese Guideline on the Management of Asymptomatic Hyperuricemia ―2021

[Presentation] 教育セッション III-２循環器疾患における尿酸の意義を考える心血管疾患と尿酸－高血圧から心房細動まで－2025

[Presentation] 健診データを用いて運動と血清尿酸値との関係を明らかにする2025