Shitara Kohei 設楽紘平

… Alternative Names

設楽紘平シタラコウヘイ

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Researcher Number	20730419
Other IDs
Affiliation (Current)	2026: 国立研究開発法人国立がん研究センター, 東病院, 科長
Affiliation (based on the past Project Information) *help	2023 – 2024: 国立研究開発法人国立がん研究センター, 東病院, 科長 2021 – 2022: 国立研究開発法人国立がん研究センター, 東病院, 医長 2017 – 2020: 国立研究開発法人国立がん研究センター, 東病院, 医員
Review Section/Research Field	Except Principal Investigator Medium-sized Section 50:Oncology and related fields / General surgery
Keywords	Except Principal Investigator 空間的解析 / 制御性T細胞 / 免疫寛容 / 免疫監視 / 腫瘍免疫 / 免疫機能解析 / 腫瘍浸潤リンパ球 / 遺伝子発現 / トリプルネガティブ乳癌 / pCR … More / predictor / TILs / 免疫染色 / TNBC / 亜分類 / TIL / トリプルネガティブ乳がん Less

Elucidation of regulation mechanisms of immune surveillance and tolerance by spatial multi-scale analysis of cancer
- Principal Investigator
  
  Nishikawa Hiroyoshi
- Project Period (FY)
  2022 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Review Section
  
  Medium-sized Section 50:Oncology and related fields
- Research Institution
  Nagoya University
New Classification of triple negative breast cancer (TNBC) based on immune status with clinical characteristic
- Principal Investigator
  
  Kogawa Takahiro
- Project Period (FY)
  2017 – 2021
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  General surgery
- Research Institution
  National Cancer Center Japan

All 2025 2024 2022

All Journal Article Presentation

[Journal Article] Atezolizumab following definitive chemoradiotherapy in patients with unresectable locally advanced esophageal squamous cell carcinoma - a multicenter phase 2 trial (EPOC1802)2025
- Author(s)
  Bando H, Kumagai S, Kotani D,・・・（22名）・・・Nishikawa H, Shitara K, Yoshino T, Kojima T
- Journal Title
  
  Nat Cancer.
  
  Volume: 6(3) Issue: 3 Pages: 445-459
- DOI
  10.1038/s43018-025-00918-1
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-22H00455, KAKENHI-PROJECT-23K28464
[Journal Article] The Tumor Immune Microenvironment and Therapeutic Efficacy of Trastuzumab Deruxtecan in Gastric Cancer.2025
- Author(s)
  Koganemaru S, Koyama S, Suto F,・・・(13名)・・・ Nishikawa H, Shitara K
- Journal Title
  
  Cancer Res Commun.
  
  Volume: 5(1) Issue: 1 Pages: 84-93
- DOI
  10.1158/2767-9764.crc-24-0302
- Data Source
  KAKENHI-PROJECT-22H00455
[Journal Article] The HSP90 Inhibitor Pimitespib Targets Regulatory T Cells in the Tumor Microenvironment.2025
- Author(s)
  Tsuge A, Watanabe S, Kawazoe A, ・・・（11名）・・・Shitara K, Koyama S, Nishikawa H
- Journal Title
  
  Cancer Immunol Res.
  
  Volume: 13(2) Issue: 2 Pages: 273-285
- DOI
  10.1158/2326-6066.cir-24-0713
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-22H00455, KAKENHI-PROJECT-24K02459, KAKENHI-PROJECT-24K22071, KAKENHI-PROJECT-24KJ1239, KAKENHI-PROJECT-23KK0149
[Journal Article] Multiomic molecular characterization of the response to combination immunotherapy in MSS/pMMR metastatic colorectal cancer2024
- Author(s)
  Takei S、Tanaka Y、Lin Yi-Tzu、Koyama S、Fukuoka S、Hara H、Nakamura Y、Kuboki Y、Kotani D、Kojima T、Bando H、Mishima S、Ueno T、Kojima S、Wakabayashi M、Sakamoto N、Kojima M、Kuwata T、Yoshino T、Nishikawa H、Mano H、Endo I、Shitara K、Kawazoe A
- Journal Title
  
  Journal for ImmunoTherapy of Cancer
  
  Volume: 12 Issue: 2 Pages: 8210-8210
- DOI
  10.1136/jitc-2023-008210
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21K12117, KAKENHI-PROJECT-22H00455, KAKENHI-PROJECT-21H02795
[Journal Article] A multicenter, open-label, single-arm phase I trial of neoadjuvant nivolumab monotherapy for resectable gastric cancer2022
- Author(s)
  Hasegawa H, Shitara K, Takiguchi S, Takiguchi N, Ito S, Kochi M, Horinouchi H, Kinoshita T, Yoshikawa T, Muro K, Nishikawa H, Suna H, Kodera Y
- Journal Title
  
  Gastric Cancer
  
  Volume: － Issue: 3 Pages: 619-628
- DOI
  10.1007/s10120-022-01286-w
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17H06162, KAKENHI-PROJECT-22H00455
[Journal Article] Updated efficacy outcomes of anti-PD-1 antibodies plus multikinase inhibitors for advanced gastric cancer patients with or without liver metastases in clinical trials.2022
- Author(s)
  Yukami H, Kawazoe A, Lin YT, Koyama S,・・・（他18名）・・・, Doi T, Nishikawa H, Shitara K
- Journal Title
  
  Clin Cancer Res.
  
  Volume: 28 Issue: 16 Pages: 3480-3488
- DOI
  10.1158/1078-0432.ccr-22-0630
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-22H00455
[Journal Article] Lactic acid promotes PD-1 expression in regulatory T cells in highly glycolytic tumor microenvironments2022
- Author(s)
  Kumagai S, Koyama S, Itahashi K, Tanegashima T, Lin YT, Togashi Y, Kamada T, Irie T, Okumura G, Kono H, Ito D, Fujii R, Watanabe S, Sai A, Aokage K, Suzuki J, Ishii G, Kuwata T, Sakamoto N, Kawazu M, Ueno T, Mori T, Yamazaki N, Tsuboi M, Yatabe Y, Kinoshita T, Doi T, Shitara K, Mano H, Nishikawa H
- Journal Title
  
  Cancer Cell
  
  Volume: 40 Issue: 2 Pages: 201-218
- DOI
  10.1016/j.ccell.2022.01.001
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17H06162, KAKENHI-PROJECT-20H03461, KAKENHI-PROJECT-20H03694, KAKENHI-PROJECT-20H04519, KAKENHI-PROJECT-21H02772, KAKENHI-PROJECT-20K07383, KAKENHI-PROJECT-20K08531, KAKENHI-PROJECT-21K07112, KAKENHI-PROJECT-21K07252, KAKENHI-PROJECT-21K12117, KAKENHI-PROJECT-16H06279, KAKENHI-PROJECT-22KJ3156, KAKENHI-PROJECT-22H00455
[Presentation] First-line regorafenib with nivolumab and FOLFOX or CapeOX in patients with advanced gastric, gastroesophageal junction, and esophageal adenocarcinoma: a single-arm, phase Ib/II trial (REGONIVOCTx, EPOC2104)2024
- Author(s)
  Akihito Kawazoe, Tadayoshi Hashimoto, ・・・(13名)・・・, Hiroyoshi Nishikawa, Kohei Shitara
- Organizer
  2024 ASCO Annual Meeting
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-22H00455
[Presentation] Identification of a distinctive metabolic checkpoint of regulatory T cells in the tumor microenvironment2022
- Author(s)
  Shogo Kumagai, Shohei Koyama, ・・・（他10名）・・・Kohei Shitara, Hiroyuki Mano, Hiroyoshi Nishikawa
- Organizer
  JCA 2022
- Invited
- Data Source
  KAKENHI-PROJECT-22H00455

1. Kogawa Takahiro (70444916)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
2. Nishikawa Hiroyoshi (10444431)

# of Collaborated Projects: 1 results

# of Collaborated Products: 8 results
3. 土井俊彦 (20522907)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
4. 藤井誠志 (30314743)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
5. 原野謙一 (80627258)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
6. 内藤陽一 (90590373)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
7. 上野敏秀

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
8. 河野隆志

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Shitara Kohei 設楽 紘平

設楽 紘平 シタラ コウヘイ

Research Projects

Research Products

Co-Researchers

Elucidation of regulation mechanisms of immune surveillance and tolerance by spatial multi-scale analysis of cancer

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

New Classification of triple negative breast cancer (TNBC) based on immune status with clinical characteristic

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] Atezolizumab following definitive chemoradiotherapy in patients with unresectable locally advanced esophageal squamous cell carcinoma - a multicenter phase 2 trial (EPOC1802)2025

Author(s)

Journal Title

DOI

Data Source

[Journal Article] The Tumor Immune Microenvironment and Therapeutic Efficacy of Trastuzumab Deruxtecan in Gastric Cancer.2025

Author(s)

Journal Title

DOI

Data Source

[Journal Article] The HSP90 Inhibitor Pimitespib Targets Regulatory T Cells in the Tumor Microenvironment.2025

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Multiomic molecular characterization of the response to combination immunotherapy in MSS/pMMR metastatic colorectal cancer2024

Author(s)

Journal Title

DOI

Data Source

[Journal Article] A multicenter, open-label, single-arm phase I trial of neoadjuvant nivolumab monotherapy for resectable gastric cancer2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Updated efficacy outcomes of anti-PD-1 antibodies plus multikinase inhibitors for advanced gastric cancer patients with or without liver metastases in clinical trials.2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Lactic acid promotes PD-1 expression in regulatory T cells in highly glycolytic tumor microenvironments2022

Author(s)

Journal Title

DOI

Data Source

[Presentation] First-line regorafenib with nivolumab and FOLFOX or CapeOX in patients with advanced gastric, gastroesophageal junction, and esophageal adenocarcinoma: a single-arm, phase Ib/II trial (REGONIVOCTx, EPOC2104)2024

Author(s)

Organizer

Data Source

[Presentation] Identification of a distinctive metabolic checkpoint of regulatory T cells in the tumor microenvironment2022

Author(s)

Organizer

Data Source

Shitara Kohei 設楽紘平

設楽紘平シタラコウヘイ