Ogasawara Yasushi 小笠原泰志

Researcher Number	20732986
Other IDs
Affiliation (Current)	2025: 北海道大学, 工学研究院, 准教授
Affiliation (based on the past Project Information) *help	2020 – 2024: 北海道大学, 工学研究院, 准教授 2016 – 2019: 北海道大学, 工学研究院, 助教 2017: 北海道大学, 大学院工学研究院, 助教
Review Section/Research Field	Principal Investigator Basic Section 38040:Bioorganic chemistry-related / Bioorganic chemistry Except Principal Investigator Transformative Research Areas, Section (II) / Broad Section F / Biomolecular chemistry
Keywords	Principal Investigator 生合成 / 酵素 / 天然物化学 / 天然物 / 三員環 / 生理活性物質 / 反応機構 / 阻害剤 / エピメラーゼ / ペプチド … More / 抗生物質 / シュードペプチド / 二次代謝 / 放線菌 / 疑似ペプチド / アミド結合 / ペプチドリガーゼ … More Except Principal Investigator 生合成 / 放線菌 / ペプチド / シュードペプチド / 酵素 / 亜硝酸 / 二次代謝 / 天然物 / ジアゾ基 / ラッソペプチド / 天然有機化合物 / 異性化 / ポリグルタミン酸 / リボソームペプチド / ペプチドグリカン / ペプチドエピメラーゼ / エピメラーゼ / ケトメミシン / ATP-grasp / カルボニルメチレン / ペプチドリガーゼ / カルボニルメチレン構造 / シュードトリペプチド / ATP-grasp ligase Less

生理活性天然物の生合成に関わる三員環構築酵素の精密解析Principal Investigator
- Principal Investigator
  
  小笠原泰志
- Project Period (FY)
  2023 – 2025
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 38040:Bioorganic chemistry-related
- Research Institution
  Hokkaido University
Dissecting biosynthetic machineries of natural peptides leading to structural and functional diversities.
- Principal Investigator
  
  大利徹
- Project Period (FY)
  2022 – 2026
- Research Category
  
  Grant-in-Aid for Scientific Research (S)
- Review Section
  
  Broad Section F
- Research Institution
  Hokkaido University
Enhancing the diversity of peptides by amino acids with reactive functional groups
- Principal Investigator
  
  勝山陽平
- Project Period (FY)
  2022 – 2026
- Research Category
  
  Grant-in-Aid for Transformative Research Areas (A)
- Review Section
  
  Transformative Research Areas, Section (II)
- Research Institution
  The University of Tokyo
Analysis of new peptide epimerases for the biosynthesis of peptide natural productsPrincipal Investigator
- Principal Investigator
  
  Ogasawara Yasushi
- Project Period (FY)
  2018 – 2021
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 38040:Bioorganic chemistry-related
- Research Institution
  Hokkaido University
Exploring and functional analysis of peptide ligase orthologsPrincipal Investigator
- Principal Investigator
  
  Ogasawara Yasushi
- Project Period (FY)
  2016 – 2017
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Bioorganic chemistry
- Research Institution
  Hokkaido University
Biosynthesis of the Carbonylmethylene Structure Found in a Class of Pseudotripeptides, Ketomemicins
- Principal Investigator
  
  Dairi Tohru
- Project Period (FY)
  2015 – 2017
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Biomolecular chemistry
- Research Institution
  Hokkaido University

All 2024 2023 2022 2021 2020 2019 2018 2017 2016 2015

All Journal Article Presentation Book

[Book] ペプチド医薬品のスクリーニング・安定化・製剤化技術2017
- Author(s)
  小笠原泰志、大利徹、他（合計110名）
- Total Pages
  557
- Publisher
  技術情報協会
- ISBN
  9784861046872
- Data Source
  KAKENHI-PROJECT-16K18692
[Journal Article] Identification of a new oligomycin derivative as a specific inhibitor of the alternative peptidoglycan biosynthetic pathway2024
- Author(s)
  Umetsu Shuhei、Tsunoda Takeshi、Kiyanagi Haruka、Inahashi Yuki、Nonaka Kenichi、Dairi Tohru、Ogasawara Yasushi
- Journal Title
  
  The Journal of Antibiotics
  
  Volume: 77 Issue: 3 Pages: 182-184
- DOI
  10.1038/s41429-023-00693-0
- Peer Reviewed
- Data Source
  KAKENHI-PLANNED-22H05130, KAKENHI-PROJECT-22H04976, KAKENHI-PROJECT-23K26838
[Journal Article] N-Formimidoylation/-iminoacetylation modification in aminoglycosides requires FAD-dependent and ligand-protein NOS bridge dual chemistry2023
- Author(s)
  Wang Yung-Lin、Chang Chin-Yuan、Hsu Ning-Shian、Lo I-Wen、Lin Kuan-Hung、Chen Chun-Liang、Chang Chi-Fon、Wang Zhe-Chong、Ogasawara Yasushi、Dairi Tohru、Maruyama Chitose、Hamano Yoshimitsu、Li Tsung-Lin
- Journal Title
  
  Nature Communications
  
  Volume: 14 Issue: 1 Pages: 2528-2528
- DOI
  10.1038/s41467-023-38218-w
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-22K05412, KAKENHI-PLANNED-22H05122, KAKENHI-PROJECT-22H04976
[Journal Article] Structure of lasso peptide epimerase MslH reveals metal-dependent acid/base catalytic mechanism2023
- Author(s)
  Nakashima Yu、Kawakami Atsushi、Ogasawara Yasushi、Maeki Masatoshi、Tokeshi Manabu、Dairi Tohru、Morita Hiroyuki
- Journal Title
  
  Nature Communications
  
  Volume: 14 Issue: 1 Pages: 4752-4752
- DOI
  10.1038/s41467-023-40232-x
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PLANNED-22H05130, KAKENHI-PROJECT-22H04976, KAKENHI-PROJECT-23K24040
[Journal Article] Peptide epimerase-dehydratase complex responsible for biosynthesis of the linaridin class ribosomal peptides2023
- Author(s)
  Xiao Wanlu、Tsunoda Takeshi、Maruyama Chitose、Hamano Yoshimitsu、Ogasawara Yasushi、Dairi Tohru
- Journal Title
  
  Bioscience, Biotechnology, and Biochemistry
  
  Volume: 87 Issue: 11 Pages: 1316-1322
- DOI
  10.1093/bbb/zbad106
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22K05412, KAKENHI-PLANNED-22H05122, KAKENHI-PLANNED-22H05130, KAKENHI-PROJECT-22H04976, KAKENHI-PROJECT-23K26838
[Journal Article] Peptide Epimerase Responsible for <scp>d</scp>-Amino Acid Introduction in Poly-γ-glutamic Acid Biosynthesis2023
- Author(s)
  Kato Hinata、Sakuta Moeka、Tsunoda Takeshi、Nakashima Yu、Morita Hiroyuki、Ogasawara Yasushi、Dairi Tohru
- Journal Title
  
  Biomacromolecules
  
  Volume: 25 Issue: 1 Pages: 349-354
- DOI
  10.1021/acs.biomac.3c01000
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PLANNED-22H05130, KAKENHI-PROJECT-22H04976, KAKENHI-PROJECT-23K26838
[Journal Article] First direct evidence for direct cell-membrane penetrations of polycationic homopoly(amino acid)s produced by bacteria2022
- Author(s)
  Takeuchi Yamato、Ushimaru Kazunori、Kaneda Kohei、Maruyama Chitose、Ito Takashi、Yamanaka Kazuya、Ogasawara Yasushi、Katano Hajime、Kato Yasuo、Dairi Tohru、Hamano Yoshimitsu
- Journal Title
  
  Communications Biology
  
  Volume: 5 Issue: 1 Pages: 1132-1132
- DOI
  10.1038/s42003-022-04110-4
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-21K05403, KAKENHI-PLANNED-22H05122, KAKENHI-PROJECT-22H04976
[Journal Article] Biosynthetic Gene Cluster of Linaridin Peptides Contains Epimerase Gene2022
- Author(s)
  Xiao Wanlu、Satoh Yasuharu、Ogasawara Yasushi、Dairi Tohru
- Journal Title
  
  ChemBioChem
  
  Volume: 23 Issue: 12
- DOI
  10.1002/cbic.202100705
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22H04976
[Journal Article] Discovery of an alternative pathway of peptidoglycan biosynthesis: A new target for pathway specific inhibitors2021
- Author(s)
  Ogasawara Yasushi、Dairi Tohru
- Journal Title
  
  Journal of Industrial Microbiology and Biotechnology
  
  Volume: 48 Issue: 9-10
- DOI
  10.1093/jimb/kuab038
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18K05449, KAKENHI-PROJECT-18H03937
[Journal Article] Identification of the peptide epimerase MslH responsible for d-amino acid introduction at the C-terminus of ribosomal peptides2021
- Author(s)
  Feng Zhi、Ogasawara Yasushi、Dairi Tohru
- Journal Title
  
  Chemical Science
  
  Volume: 12 Issue: 7 Pages: 2567-2574
- DOI
  10.1039/d0sc06308h
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K05449, KAKENHI-PLANNED-16H06452, KAKENHI-PROJECT-18H03937
[Journal Article] Identification of pulvomycin as an inhibitor of the futalosine pathway2021
- Author(s)
  Ogasawara Yasushi、Umetsu Shuhei、Inahashi Yuki、Nonaka Kenichi、Dairi Tohru
- Journal Title
  
  The Journal of Antibiotics
  
  Volume: 74 Issue: 11 Pages: 825-829
- DOI
  10.1038/s41429-021-00465-8
- NAID
  120007193348
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18K05449, KAKENHI-PROJECT-18H03937
[Journal Article] Identification of Cyclopropane Formation in the Biosyntheses of Hormaomycins and Belactosins: Sequential Nitration and Cyclopropanation by Metalloenzymes2021
- Author(s)
  Li Xiaojun、Shimaya Ryo、Dairi Tohru、Chang Wei‐chen、Ogasawara Yasushi
- Journal Title
  
  Angewandte Chemie International Edition
  
  Volume: 61 Issue: 7
- DOI
  10.1002/anie.202113189
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K05449, KAKENHI-PROJECT-18H03937, KAKENHI-PROJECT-22H04976
[Journal Article] New enzymes for peptide biosynthesis in microorganisms2019
- Author(s)
  Ogasawara Yasushi
- Journal Title
  
  Bioscience, Biotechnology, and Biochemistry
  
  Volume: 83 Issue: 4 Pages: 589-597
- DOI
  10.1080/09168451.2018.1559028
- Data Source
  KAKENHI-PROJECT-18K05449
[Journal Article] Involvement of Peptide Epimerization in Poly-γ-glutamic Acid Biosynthesis2019
- Author(s)
  Ogasawara Yasushi、Shigematsu Mayuko、Sato Shota、Kato Hinata、Dairi Tohru
- Journal Title
  
  Organic Letters
  
  Volume: 21 Issue: 11 Pages: 3972-3975
- DOI
  10.1021/acs.orglett.9b01121
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K05449, KAKENHI-PROJECT-18H03937
[Journal Article] In vitro characterization of MitE and MitB: Formation of N-acetylglucosaminyl-3-amino-5-hydroxybenzoyl-MmcB as a key intermediate in the biosynthesis of antitumor antibiotic mitomycins2019
- Author(s)
  Ogasawara Yasushi、Nakagawa Yo、Maruyama Chitose、Hamano Yoshimitsu、Dairi Tohru
- Journal Title
  
  Bioorganic & Medicinal Chemistry Letters
  
  Volume: 29 Issue: 16 Pages: 2076-2078
- DOI
  10.1016/j.bmcl.2019.07.009
- NAID
  120007132051
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K05449, KAKENHI-PROJECT-18H03937
[Journal Article] Identification of actinomycin D as a specific inhibitor of the alternative pathway of peptidoglycan biosynthesis2019
- Author(s)
  Ogasawara Yasushi、Shimizu Yohei、Sato Yohei、Yoneda Tomoki、Inokuma Yasuhide、Dairi Tohru
- Journal Title
  
  The Journal of Antibiotics
  
  Volume: 73 Issue: 2 Pages: 125-127
- DOI
  10.1038/s41429-019-0252-2
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K05449, KAKENHI-PLANNED-16H06452, KAKENHI-PROJECT-17H04872
[Journal Article] Biosynthetic Gene Cluster of a D-Tryptophan-Containing Lasso Peptide, MS-2712018
- Author(s)
  Feng Zhi、Ogasawara Yasushi、Nomura Satoshi、Dairi Tohru
- Journal Title
  
  ChemBioChem
  
  Volume: 19 Issue: 19 Pages: 2045-2048
- DOI
  10.1002/cbic.201800315
- NAID
  120006727595
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K05449, KAKENHI-PROJECT-18H03937
[Journal Article] Functional analysis of methyltransferases participating in streptothricin-related antibiotic biosynthesis2018
- Author(s)
  Niikura Haruka、Maruyama Chitose、Ogasawara Yasushi、Shin-ya Kazuo、Dairi Tohru、Hamano Yoshimitsu
- Journal Title
  
  J. Biosci. Bioeng.
  
  Volume: 125 Issue: 2 Pages: 148-154
- DOI
  10.1016/j.jbiosc.2017.09.004
- NAID
  40021471176
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-15H03110, KAKENHI-PLANNED-16H06452, KAKENHI-PLANNED-16H06445
[Journal Article] Peptide Epimerization Machineries Found in Microorganisms2018
- Author(s)
  Ogasawara Yasushi、Dairi Tohru
- Journal Title
  
  Front. Microbiol.
  
  Volume: 9 Pages: 1-9
- DOI
  10.3389/fmicb.2018.00156
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-15H03110, KAKENHI-PROJECT-16K18692, KAKENHI-PROJECT-18H03937
[Journal Article] 放線菌が生み出した疑似ペプチド化合物-疑似ペプチド（ケトメミシン）がもつカルボニルメチレンの生合成を解明-2018
- Author(s)
  小笠原泰志, 大利徹
- Journal Title
  
  化学と生物
  
  Volume: 56 Pages: 76-78
- NAID
  130007563335
- Data Source
  KAKENHI-PROJECT-15H03110
[Journal Article] 疑似ペプチド（ケトメミシン）がもつカルボニルメチレンの生合成を解明2018
- Author(s)
  小笠原泰志、大利徹
- Journal Title
  
  KAGAKU TO SEIBUTSU
  
  Volume: 56 Issue: 2 Pages: 76-78
- DOI
  10.1271/kagakutoseibutsu.56.76
- NAID
  130007563335
- ISSN
  0453-073X, 1883-6852
- Year and Date
  2018-01-20
- Language
  Japanese
- Data Source
  KAKENHI-PROJECT-16K18692
[Journal Article] Biosynthesis of Oligopeptides Using ATP-Grasp Enzymes2017
- Author(s)
  Ogasawara Yasushi、Dairi Tohru
- Journal Title
  
  Chemistry
  
  Volume: 23 Issue: 45 Pages: 10714-10724
- DOI
  10.1002/chem.201700674
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-15H03110, KAKENHI-PROJECT-16K18692
[Journal Article] Biosynthesis of the Carbonylmethylene Structure Found in the Ketomemicin Class of Pseudotripeptides2017
- Author(s)
  J. Kawata, T. Naoe, Y. Ogasawara, and T. Dairi
- Journal Title
  
  Angew. Chem. Int. Ed.
  
  Volume: 56 Issue: 8 Pages: 2026-2029
- DOI
  10.1002/anie.201611005
- NAID
  120006383813
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-15H03110, KAKENHI-PROJECT-16K18692
[Journal Article] Exploring peptide ligase orthologs in actinobacteria-discovery of pseudopeptide natural products, ketomemicins-2016
- Author(s)
  Y. Ogasawara, J. Kawata, M. Noike, Y. Satoh, K. Furihata, and T. Dairi
- Journal Title
  
  ACS Chem. Biol.
  
  Volume: 11 Issue: 6 Pages: 1686-1692
- DOI
  10.1021/acschembio.6b00046
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-15H03110
[Journal Article] Structure and activity relationships of the anti-Mycobacterium antibiotics resorcinomycin and pheganomycin2016
- Author(s)
  Y. Ogasawara, K. Ooya, M. Fujimori, M. Noike, and T. Dairi
- Journal Title
  
  J. Antibiot.
  
  Volume: 69 Issue: 2 Pages: 119-120
- DOI
  10.1038/ja.2015.88
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-15H03110
[Journal Article] Characterization of three amidinotransferases involved in the biosynthesis of ketomemicins2016
- Author(s)
  Y. Ogasawara, M. Fujimori, J. Kawata, and T. Dairi
- Journal Title
  
  Bioorg. Med. Chem. Lett.
  
  Volume: 26 Issue: 15 Pages: 3662-3664
- DOI
  10.1016/j.bmcl.2016.05.090
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-15H03110, KAKENHI-PROJECT-16K18692
[Journal Article] Identification and analysis of the resorcinomycin biosynthetic gene cluster.2015
- Author(s)
  K. Ooya, Y. Ogasawara, M. Noike, and T. Dairi
- Journal Title
  
  Biosci. Biotechnol. Biochem
  
  Volume: 79 Issue: 11 Pages: 1833-1837
- DOI
  10.1080/09168451.2015.1050992
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-15H03110
[Presentation] ヒドラジド含有型天然物の生合成に関する研究2024
- Author(s)
  西田壮吾, 成冨駿, 小倉勇輝, 山崎陽香, 角田毅, 勝山陽平, 大西康夫, 小笠原泰志, 大利徹
- Organizer
  2024年度日本農芸化学会大会
- Data Source
  KAKENHI-PROJECT-22H04976
[Presentation] 新規ペプチドグリカン生合成経路阻害剤の探索2024
- Author(s)
  梅津秀平, 角田毅, 鬼柳春花, 稲橋佑起, 野中健一, 小笠原泰志, 大利徹
- Organizer
  日本農芸化学会2024年度　東京大会
- Data Source
  KAKENHI-PLANNED-22H05130
[Presentation] イソキサゾリン構造を有するアシビシンの生合成解析2024
- Author(s)
  布田大志、小笠原泰志、大利徹
- Organizer
  2024年度日本農芸化学会大会
- Data Source
  KAKENHI-PROJECT-22H04976
[Presentation] 新規ペプチドグリカン生合成経路阻害剤の探索2024
- Author(s)
  梅津秀平, 角田毅, 鬼柳春花, 稲橋佑起, 野中健一, 小笠原泰志, 大利徹
- Organizer
  日本農芸化学会2024年度大会
- Data Source
  KAKENHI-PROJECT-23K26838
[Presentation] α,α-二置換アミノ酸を有するラクタシスチンの生合成研究2024
- Author(s)
  角田毅、古村淳吉、山﨑陽香、小笠原泰志、大利徹
- Organizer
  2024年度日本農芸化学会大会
- Data Source
  KAKENHI-PROJECT-22H04976
[Presentation] 新規メナキノン生合成経路阻害剤の探索2024
- Author(s)
  鬼柳春花, 菊池麻里江, 角田毅, 野中健一, 稲橋佑起, 小笠原泰志, 大利徹
- Organizer
  日本農芸化学会2024年度大会
- Data Source
  KAKENHI-PROJECT-23K26838
[Presentation] 新規メナキノン生合成経路阻害剤の探索2024
- Author(s)
  鬼柳春花, 菊池麻里江, 角田毅, 野中健一, 稲橋佑起, 小笠原泰志, 大利徹
- Organizer
  日本農芸化学会2024年度　東京大会
- Data Source
  KAKENHI-PLANNED-22H05130
[Presentation] イソキサゾリン構造を有するアシビシンの生合成解析2024
- Author(s)
  布田大志, 小笠原泰志, 大利徹
- Organizer
  日本農芸化学会2024年度大会
- Data Source
  KAKENHI-PROJECT-23K26838
[Presentation] 新規ペプチドグリカン生合成経路阻害剤の探索2024
- Author(s)
  梅津秀平、角田毅、鬼柳春花、稲橋佑起、野中健一、小笠原泰志、大利徹
- Organizer
  2024年度日本農芸化学会大会
- Data Source
  KAKENHI-PROJECT-22H04976
[Presentation] イソキサゾリン構造を有するアシビシンの生合成解析2024
- Author(s)
  布田大志, 小笠原泰志, 大利徹
- Organizer
  日本農芸化学会2024年度　東京大会
- Data Source
  KAKENHI-PLANNED-22H05130
[Presentation] 抗腫瘍抗生物質マイトマイシンの生合成解析2024
- Author(s)
  高橋佑大, 角田毅, 大利徹, 小笠原泰志
- Organizer
  日本農芸化学会2024年度大会
- Data Source
  KAKENHI-PROJECT-23K26838
[Presentation] 抗腫瘍抗生物質マイトマイシンの生合成解析2024
- Author(s)
  高橋佑大, 角田毅, 大利徹, 小笠原泰志
- Organizer
  日本農芸化学会2024年度　東京大会
- Data Source
  KAKENHI-PLANNED-22H05130
[Presentation] αα二置換アミノ酸を有する天然物の合成研究2023
- Author(s)
  角田毅, 古村淳吉, 山崎陽香, 小笠原泰志, 大利徹
- Organizer
  第37回日本放線菌学会大会
- Data Source
  KAKENHI-PROJECT-23K26838
[Presentation] Unprecedented Peptide Epimerases for Natural Products Biosynthesis2023
- Author(s)
  Yasushi Ogasawara and Tohru Dairi
- Organizer
  Japan-German Joint Symposium on Natural Product Biosynthesis（Kyoto）
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PLANNED-22H05130
[Presentation] Two novel peptide epimerases involved in the biosynthesis of ribosomally synthesized and posttranslationally modified peptides2023
- Author(s)
  Yasushi Ogasawara and Tohru Dairi
- Organizer
  3rd Japan-Switzerland-Germany Workshop on Biocatalysis and Bioprocess Development
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-22H04976
[Presentation] Unprecedented Peptide Epimerases for Natural Products Biosynthesis2023
- Author(s)
  Yasushi Ogasawara and Tohru Dairi
- Organizer
  Japan-German Joint Symposium on Natural Product Biosynthesis
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-23K26838
[Presentation] 新規ペプチドエピメラーゼMslHの反応機構の解析2023
- Author(s)
  川上篤士、中嶋優、森田洋行、小笠原泰志、大利徹
- Organizer
  2023年度日本農芸化学会大会
- Data Source
  KAKENHI-PROJECT-22H04976
[Presentation] Catalytic mechanism of MslH epimerizing C-terminal L-Trp of ribosomal lasso peptide, MS-2712023
- Author(s)
  Atsushi Kawakami, Yu Nakashima, Hiroyuki Morita, Yasushi Ogasawara, Tohru Dairi
- Organizer
  4th International Conference on Natural Product Discovery and Development in the Genomic Era
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-22H04976
[Presentation] INVOLVEMENT OF PEPTIDE EPIMERIZATION IN THE BIOSYTHESIS OF THE LINARIDIN CLASS RIBOSOMALLY SYNTHESIZED AND POST-TRANSLATIONALLY MODIFIED PEPTIDES2023
- Author(s)
  Wanlu Xiao, Yasushi Ogasawara, Yasuharu Satoh and Tohru Dairi
- Organizer
  4th International Conference on Natural Product Discovery and Development in the Genomic Era
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-22H04976
[Presentation] ペプチドグリカン新規生合成経路阻害剤の探索2023
- Author(s)
  梅津秀平, 角田毅, 稲橋佑起, 野中健一, 小笠原泰志, 大利徹
- Organizer
  2023年度（第37回）日本放線菌学会（広島県東広島市）
- Data Source
  KAKENHI-PLANNED-22H05130
[Presentation] ペプチドグリカン新規生合成経路阻害剤の探索2023
- Author(s)
  梅津秀平, 角田毅, 稲橋佑起, 野中健一, 小笠原泰志, 大利徹
- Organizer
  第37回日本放線菌学会大会
- Data Source
  KAKENHI-PROJECT-23K26838
[Presentation] ペプチド異性化酵素Murlの構造機能解析を指向したリガンド分子の合成研究2023
- Author(s)
  山岡拓海、石川文洋、小笠原泰志、大利徹、田邊元三
- Organizer
  日本薬学会第143年会
- Data Source
  KAKENHI-PROJECT-22H04976
[Presentation] 微細藻類由来DHA合成酵素のketosynthaseドメインの機能解析2023
- Author(s)
  尾形海斗、小林飛悠、佐藤康治、丸山千登勢、濱野吉十、小笠原泰志、大利徹
- Organizer
  2023年度日本農芸化学会大会
- Data Source
  KAKENHI-PROJECT-22H04976
[Presentation] 新規ペプチドエピメラーゼMurLの反応機構解析2023
- Author(s)
  堀内柾希、中尾優文、中嶋優、森田洋行、小笠原泰志、大利徹
- Organizer
  2023年度日本農芸化学会大会
- Data Source
  KAKENHI-PROJECT-22H04976
[Presentation] Two Novel Peptide Epimerases Involved in the Biosynthesis of Ribosomally Synthesized and Posttranslationally Modified Peptides2023
- Author(s)
  Yasushi Ogasawara and Tohru Dairi
- Organizer
  3rd Japan-Switzerland-Germany Workshop on Biocatalysis and Bioprocess Development
- Int'l Joint Research
- Data Source
  KAKENHI-PLANNED-22H05130
[Presentation] Cyclopropane Formation in the Biosyntheses of Hormaomycins and Belactosins: Sequential Nitration and Cyclopropanation by Metalloenzymes2023
- Author(s)
  Yasushi Ogasawara, Ryo Shimaya, Wei-chen Chang, Tohru Dairi
- Organizer
  4th International Conference on Natural Product Discovery and Development in the Genomic Era
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-22H04976
[Presentation] X-ray crystallographic analysis of lasso peptide epimerase; MslH2023
- Author(s)
  Yu Nakashima, Atsushi Kawakami, Yasushi Ogasawara, Tohru Dairi, and Hiroyuki Morita
- Organizer
  4th International Conference on Natural Product Discovery and Development in the Genomic Era
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-22H04976
[Presentation] Phenylalanine hydroxylase found in the resormycin biosynthetic enzymes2023
- Author(s)
  Chihiro Kishi, Yasushi Ogasawara, Kazuya Yamanaka, Tohru Dairi, Yoshimitsu Hamano, Chitose Maruyama
- Organizer
  4th International Conference on Natural Product Discovery and Development in the Genomic Era
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-22H04976
[Presentation] Resormycin生合成酵素群より見出したphenylalanine水酸化酵素の機能解析2023
- Author(s)
  岸千紘、小笠原泰志、山中一也、五十嵐雅之、大利徹、濱野吉十、丸山千登勢
- Organizer
  2023年度日本農芸化学会大会
- Data Source
  KAKENHI-PROJECT-22H04976
[Presentation] Two Novel Peptide Epimerases Involved in the Biosynthesis of Ribosomally Synthesized and Posttranslationally Modified Peptides2023
- Author(s)
  Yasushi Ogasawara and Tohru Dairi
- Organizer
  3rd Japan-Switzerland-Germany Workshop on Biocatalysis and Bioprocess Development
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-23K26838
[Presentation] 抗腫瘍抗生物質マイトマイシンの生合成解析2023
- Author(s)
  高橋佑大, 中川陽, 角田毅, 大利徹, 小笠原泰志
- Organizer
  第37回日本放線菌学会大会
- Data Source
  KAKENHI-PROJECT-23K26838
[Presentation] 新規ペプチドグリカン生合成経路阻害剤の探索2023
- Author(s)
  梅津秀平、角田毅、稲橋佑起、野中健一、小笠原泰志、大利徹
- Organizer
  2023年度（第37回）日本放線菌学会大会
- Data Source
  KAKENHI-PROJECT-22H04976
[Presentation] 抗生物質resormycinが有するβ-homolysineの生合成機構の解明2023
- Author(s)
  今堀千咲、小笠原泰志、山中一也、五十嵐雅之、大利徹、濱野吉十、丸山千登勢
- Organizer
  2023年度日本農芸化学会大会
- Data Source
  KAKENHI-PROJECT-22H04976
[Presentation] Biosynthetic Study of Antitumor Antibiotic Mitomycins2023
- Author(s)
  Yudai Takahashi, Kenichi Yokoyama, Tohru Dairi and Yasushi Ogasawara
- Organizer
  4th International Conference on Natural Product Discovery and Development in the Genomic Era
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-22H04976
[Presentation] Peptide epimerase responsible for D-amino acid introduction in poly-γ-glutamic acid biosynthesis2023
- Author(s)
  Hinata Kato, Moeka Sakuta, Takeshi Tsunoda, Yu Nakashima, Hiroyuki Morita, Yasushi Ogasawara, and Tohru Dairi
- Organizer
  The 60th Japanese Peptide Symposium
- Int'l Joint Research
- Data Source
  KAKENHI-PLANNED-22H05130
[Presentation] 抗腫瘍抗生物質マイトマイシンの生合成解析2023
- Author(s)
  高橋佑大, 中川陽, 角田毅, 大利徹, 小笠原泰志
- Organizer
  2023年度（第37回）日本放線菌学会（広島県東広島市）
- Data Source
  KAKENHI-PLANNED-22H05130
[Presentation] メナキノン新規生合成経路阻害剤の探索2023
- Author(s)
  鬼柳春花, 菊池麻里江, 小笠原泰志, 大利徹
- Organizer
  日本農芸化学会北海道支部2023年第一回講演会 2023年
- Data Source
  KAKENHI-PLANNED-22H05130
[Presentation] α,α-二置換アミノ酸を有する天然物の生合成研2023
- Author(s)
  角田毅、古村淳吉、山﨑陽香、小笠原泰志、大利徹
- Organizer
  2023年度（第37回）日本放線菌学会大会
- Data Source
  KAKENHI-PROJECT-22H04976
[Presentation] α,α-二置換アミノ酸を有する天然物の生合成研究2023
- Author(s)
  角田毅、古村淳吉、山﨑陽香、小笠原泰志、大利徹
- Organizer
  第65回天然有機化合物討論会
- Data Source
  KAKENHI-PROJECT-22H04976
[Presentation] Peptide epimerase responsible for D-amino acid introduction in poly-γ-glutamic acid biosynthesis2023
- Author(s)
  Hinata Kato, Moeka Sakuta, Takeshi Tsunoda, Yu Nakashima, Hiroyuki Morita, Yasushi Ogasawara, and Tohru Dairi
- Organizer
  The 60th Japanese Peptide Symposium
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-23K26838
[Presentation] メナキノン新規生合成経路阻害剤の探索2023
- Author(s)
  鬼柳春花, 菊池麻里江, 小笠原泰志, 大利徹
- Organizer
  日本農芸化学会北海道支部2023年第一回講演会
- Data Source
  KAKENHI-PROJECT-23K26838
[Presentation] 微細藻類由来DHA合成酵素のdehydrataseドメインの機能解析2022
- Author(s)
  小林飛悠、佐藤康治、小笠原泰志、大利徹
- Organizer
  令和4年度　日本農芸化学会北海道・東北支部合同支部会
- Data Source
  KAKENHI-PROJECT-22H04976
[Presentation] Two novel types of peptide epimerases to introduce D-amino acid residues in the biosynthesis of ribosomally synthesized and post-translationally modified peptides2022
- Author(s)
  小笠原泰志、大利徹
- Organizer
  Sapporo Summer Seminar on Natural Product Biosynthesis
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-22H04976
[Presentation] Involvement of peptide epimerization in the biosynthesis of the linaridin class ribosomally synthesized and post-translationally modified peptides2022
- Author(s)
  Wanlu Xiao, Yasushi Ogasawara, Yasuharu Satoh, and Tohru Dairi
- Organizer
  2022年度（第36回）日本放線菌学会大会
- Data Source
  KAKENHI-PROJECT-22H04976
[Presentation] Resormycin 生合成遺伝子群に見出した Phenylalanine 修飾酵素の機能解析2022
- Author(s)
  岸千紘、小笠原泰志、山中一也、五十嵐雅之、大利徹、濱野吉十、丸山千登勢
- Organizer
  2022年度（第36回）日本放線菌学会大会
- Data Source
  KAKENHI-PROJECT-22H04976
[Presentation] 抗生物質 resormycin が有するβ-homolysine の生合成機構の解明2022
- Author(s)
  今堀千咲、小笠原泰志、山中一也、五十嵐雅之、大利徹、濱野吉十、丸山千登勢
- Organizer
  2022年度（第36回）日本放線菌学会大会
- Data Source
  KAKENHI-PROJECT-22H04976
[Presentation] ポリグルタミン酸生合成に関与する新規エピメリ化酵素の解析2022
- Author(s)
  作田萌香、小笠原泰志、大利徹
- Organizer
  令和4年度　日本農芸化学会北海道・東北支部合同支部会
- Data Source
  KAKENHI-PROJECT-22H04976
[Presentation] ペプチドを基質とする新規エピメラーゼの探索と解析2022
- Author(s)
  小笠原泰志、馮智、肖碗路、重松真由子、佐藤将太、加藤陽菜多、大利徹
- Organizer
  第64回天然有機化合物討論会
- Data Source
  KAKENHI-PROJECT-22H04976
[Presentation] ラッソペプチドRES-701 の生合成研究2022
- Author(s)
  山谷優花、小笠原泰志、佐藤康治、大利徹
- Organizer
  日本農芸化学会2022年度大会
- Data Source
  KAKENHI-PROJECT-18K05449
[Presentation] 鉄/α-ケトグルタル酸依存シクロプロパン環化酵素オルソログの機能解析2022
- Author(s)
  島谷諒, 大利徹, 小笠原泰志
- Organizer
  2022年度（第36回）日本放線菌学会大会
- Data Source
  KAKENHI-PROJECT-22H04976
[Presentation] ラッソペプチド生合成を担うエピメリ化酵素 MslH のX 線結晶構造解析2022
- Author(s)
  中嶋優、川上篤士、小笠原泰志、大利徹、森田洋行
- Organizer
  日本生薬学会第68回年会
- Data Source
  KAKENHI-PROJECT-22H04976
[Presentation] 新規ペプチドエピメラーゼMslHの反応機構解析2022
- Author(s)
  川上篤士、中嶋　優、森田洋行、小笠原　泰志、大利　徹
- Organizer
  令和4年　日本農芸化学会北海道支部学術講演会
- Data Source
  KAKENHI-PROJECT-22H04976
[Presentation] Involvement of Peptide Epimerization in the biosynthesis of Linaridin Class Ribosomally Synthesized and Post-translationally Modified Peptides2022
- Author(s)
  Wanlu Xiao、Yasushi Ogasawara、Yasuharu Satoh、Tohru Dairi
- Organizer
  日本農芸化学会2022年度大会
- Data Source
  KAKENHI-PROJECT-18K05449
[Presentation] 新規ペプチドエピメラーゼMslHの反応機構解析2022
- Author(s)
  川上篤士、中嶋優、森田洋行、小笠原泰志、大利徹
- Organizer
  2022年度（第36回）日本放線菌学会大会
- Data Source
  KAKENHI-PROJECT-22H04976
[Presentation] ペプチドグリカン新規生合成経路の阻害剤探索2022
- Author(s)
  梅津秀平, 小笠原泰志, 大利徹
- Organizer
  2022年度（第36回）日本放線菌学会大会
- Data Source
  KAKENHI-PROJECT-22H04976
[Presentation] イソキサゾリン構造を有するアシビシンの生合成解析2022
- Author(s)
  布田大志、小笠原　泰志、大利　徹
- Organizer
  令和4年　日本農芸化学会北海道支部学術講演会
- Data Source
  KAKENHI-PROJECT-22H04976
[Presentation] 三員環構造を有するペプチド抗生物質ベラクトシンとホルマオマイシンの生合成研究2022
- Author(s)
  島谷諒、大利徹、小笠原泰志
- Organizer
  日本農芸化学会2022年度大会
- Data Source
  KAKENHI-PROJECT-18K05449
[Presentation] 抗腫瘍抗生物質マイトマイシンの生合成解析2022
- Author(s)
  高橋佑大、中川　陽、大利　徹、小笠原泰志
- Organizer
  令和4年　日本農芸化学会北海道支部学術講演会
- Data Source
  KAKENHI-PROJECT-22H04976
[Presentation] In vitro characterization of early steps in the biosynthesis of antitumor antibiotics mitomycins2021
- Author(s)
  Yasushi Ogasawara, Yo Nakagawa, Chitose Maruyama, Yoshimitsu Hamano and Tohru Dairi
- Organizer
  PacifiChem 2021
- Data Source
  KAKENHI-PROJECT-18K05449
[Presentation] Linaridin natural products containing D-amino acids2021
- Author(s)
  Wanlu Xiao, Yasushi Ogasawara, and Tohru Dairi
- Organizer
  2021 年度日本農芸化学会北海道支部第2 回学術講演会
- Data Source
  KAKENHI-PROJECT-18K05449
[Presentation] Dissecting the biosynthetic machinery in bacterial polyunsaturated fatty acid synthases2021
- Author(s)
  Yasushi Ogasawara and Tohru Dairi
- Organizer
  2022 Canadian Lipids and Proteins Conference
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K05449
[Presentation] 三員環構造を有するペプチド抗生物質ベラクトシンとホルマオマイシンの生合成研究2021
- Author(s)
  島谷諒, 大利徹, 小笠原泰志
- Organizer
  2021 年度日本農芸化学会北海道支部第2 回学術講演会
- Data Source
  KAKENHI-PROJECT-18K05449
[Presentation] New peptide epimerase in the biosynthesis of a D-tryptophan-containing lasso peptide, MS-2712021
- Author(s)
  Yasushi Ogasawara and Tohru Dairi
- Organizer
  Directing Biosynthesis Online
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K05449
[Presentation] 植物病原菌に見出した新規ペプチドグリカン生合成経路2020
- Author(s)
  ○小笠原泰志、大利徹
- Organizer
  第6回北大部局横断シンポジウム
- Invited
- Data Source
  KAKENHI-PROJECT-18K05449
[Presentation] 抗腫瘍抗生物質マイトマイシンの生合成解析2020
- Author(s)
  ○中川陽、小笠原泰志、大利徹
- Organizer
  2020年度日本農芸化学会北海道支部/第50回日本栄養・食料学会北海道支部合同学術講演会
- Data Source
  KAKENHI-PROJECT-18K05449
[Presentation] Identification and Characterization of the Peptide Epimerase Catalyzing Isomerization of the C-terminal L-Tryptophan Residue in the Biosynthesis of Lasso Peptide, MS-2712020
- Author(s)
  ○Zhi Feng, Yasushi Ogasawara, and Tohru Dairi
- Organizer
  2020年度日本農芸化学会北海道支部/第50回日本栄養・食料学会北海道支部合同学術講演会
- Data Source
  KAKENHI-PROJECT-18K05449
[Presentation] ポリグルタミン酸生合成におけるエピメリ化酵素の同定2020
- Author(s)
  ○加藤陽菜多、小笠原泰志、大利徹
- Organizer
  2020年度日本農芸化学会北海道支部/第50回日本栄養・食料学会北海道支部合同学術講演会
- Data Source
  KAKENHI-PROJECT-18K05449
[Presentation] Investigation of a novel epimerase in the biosynthesis of D-tryptophan containing lasso peptide, MS-2712020
- Author(s)
  ○Zhi Feng, Yasushi Ogasawara, and Tohru Dairi
- Organizer
  2020年日本農芸化学会大会、福岡
- Data Source
  KAKENHI-PROJECT-18K05449
[Presentation] Identification and Characterization of a Novel Peptide Epimerase Responsible for the C-terminal D-Tryptophan Introduction in the Biosynthesis of Lasso Peptide, MS-2712020
- Author(s)
  ○Zhi Feng, Yasushi Ogasawara, and Tohru Dairi
- Organizer
  日本農芸化学会2021年度大会
- Data Source
  KAKENHI-PROJECT-18K05449
[Presentation] 新規ＡＴＰ依存ペプチドエピメラーゼMurLの反応機構解析2020
- Author(s)
  ○中尾優文、小笠原泰志、佐藤康治、大利徹
- Organizer
  日本農芸化学会2021年度大会
- Data Source
  KAKENHI-PROJECT-18K05449
[Presentation] ポリグルタミン酸生合成におけるエピメリ化酵素の同定2020
- Author(s)
  ○加藤陽菜多、小笠原泰志、大利徹
- Organizer
  日本農芸化学会2021年度大会
- Data Source
  KAKENHI-PROJECT-18K05449
[Presentation] 新規ＡＴＰ依存ペプチドエピメラーゼMurLの反応機構解析2020
- Author(s)
  ○中尾優文、小笠原泰志、佐藤康治、大利徹
- Organizer
  2020年度日本農芸化学会北海道支部/第50回日本栄養・食料学会北海道支部合同学術講演会
- Data Source
  KAKENHI-PROJECT-18K05449
[Presentation] 抗腫瘍抗生物質マイトマイシンの生合成解析2020
- Author(s)
  ○中川陽、小笠原泰志、大利徹
- Organizer
  日本農芸化学会2021年度大会
- Data Source
  KAKENHI-PROJECT-18K05449
[Presentation] Biosynthetic Gene Cluster of a D-Tryptophan-Containing Lasso Peptide, MS-2712019
- Author(s)
  ○Zhi Feng, Yasushi Ogasawara, Satoshi Nomura, Tohru Dairi
- Organizer
  Chemical Biology and Drug Discovery. Cold Spring HarborAsia Conferences, Suzhou, China
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K05449
[Presentation] Exploration of futalosine pathway specific inhibitors2019
- Author(s)
  ○Yohei Shimizu, Kensuke Kondo, Yohei Sato, Yasushi Ogasawara and Tohru Dairi
- Organizer
  International Symposium on Biopolymer Synthesis and Degradation, Sapporo
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K05449
[Presentation] ペプチドグリカン新規生合成経路阻害剤の探索2019
- Author(s)
  ○清水庸平、佐藤洋平、小笠原泰志、米田友貴、猪熊泰英、大利徹
- Organizer
  第34回日本放線菌学会大会、札幌
- Data Source
  KAKENHI-PROJECT-18K05449
[Presentation] ポリグルタミン酸生合成における新規エピメリ化反応2019
- Author(s)
  ○佐藤将太、重松真由子、加藤陽菜多、小笠原泰志、大利徹
- Organizer
  第71回日本生物工学会大会、岡山
- Data Source
  KAKENHI-PROJECT-18K05449
[Presentation] Biosynthetic Gene Cluster of a D-Tryptophan-Containing Lasso Peptide, MS-2712019
- Author(s)
  ○Zhi Feng, Yasushi Ogasawara, Satoshi Nomura, Tohru Dairi
- Organizer
  International Symposium on Biopolymer Synthesis and Degradation, Sapporo
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K05449
[Presentation] Involvement of peptide epimerization in poly-gamma-glutamic acid biosynthesis2019
- Author(s)
  ○Yasushi Ogasawara, Mayuko Shigematsu, Shota Sato, Hinata Kato, and Tohru Dairi
- Organizer
  SIMB annual meeting, Washington DC
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K05449
[Presentation] ペプチドの構造に多様性を与える新規酵素の探索2018
- Author(s)
  小笠原泰志
- Organizer
  日本農芸化学会2018年度大会
- Invited
- Data Source
  KAKENHI-PROJECT-16K18692
[Presentation] Recognition mechanism of substrate chirality in UDP-MurNAc-L-Ala-Glu synthetase2018
- Author(s)
  Ruoyin FENG, Yasuharu SATOH, Hiroyuki MORITA, Yasushi OGASAWARA, Tohru DAIRI
- Organizer
  2019年度農芸化学会大会
- Data Source
  KAKENHI-PROJECT-18K05449
[Presentation] Biosynthetic Gene Cluster of a-D-Tryptophan Containing Lasso Peptide, MS-2712018
- Author(s)
  Zhi Feng, Yasushi Ogasawara, Satoshi Nomura and Tohru Dairi
- Organizer
  日本放線菌学会大会
- Data Source
  KAKENHI-PROJECT-18K05449
[Presentation] 微生物に見出したペプチドグリカン新規生合成酵素の解析2018
- Author(s)
  馮若茵、佐藤康治、小笠原泰志、森田洋行、吉村徹、大利徹
- Organizer
  第60回天然有機化合物討論会
- Data Source
  KAKENHI-PROJECT-18K05449
[Presentation] An unprecedented glutamate epimerase for bacterial peptidoglycan biosynthesis.2018
- Author(s)
  Ruoyin Feng, Yasuharu Sato, Yasushi Ogasawara, and Tohru Dairi.
- Organizer
  3rd European Conference on Natural Products
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K05449
[Presentation] ポリグルタミン酸生合成の解析2018
- Author(s)
  重松真由子、小笠原泰志、大利徹
- Organizer
  日本農芸化学会2018年度大会
- Data Source
  KAKENHI-PROJECT-16K18692
[Presentation] ペプチド天然物の生合成に関わる新規酵素の探索2018
- Author(s)
  小笠原　泰志
- Organizer
  日本農芸化学会北海道支部・東北支部合同支部大会
- Invited
- Data Source
  KAKENHI-PROJECT-18K05449
[Presentation] Biosynthetic Gene Cluster of a D-Tryptophan-Containing Lasso Peptide, MS-2712018
- Author(s)
  Zhi FENG, Yasushi OGASAWARA, Satoshi NOMURA, Tohru DAIRI
- Organizer
  2019年度農芸化学会大会
- Data Source
  KAKENHI-PROJECT-18K05449
[Presentation] New Enzymes for Peptide Biosynthesis in Microorganisms.2018
- Author(s)
  Yasushi Ogasawara and Tohru Dairi
- Organizer
  Japanese-German Symposium
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K05449
[Presentation] ケトメミシンにみられるカルボニルメチレン型シュードペプチドの生合成2017
- Author(s)
  直江大樹、川田順平、小笠原泰志、大利徹
- Organizer
  生合成リデザイン第一回若手セミナー
- Data Source
  KAKENHI-PROJECT-16K18692
[Presentation] ペプチド系天然化合物 JBIR-78および JBIR95 の生合成研究2017
- Author(s)
  37.竹田薫平、見目晃平、佐藤康治、小笠原泰志、新家一男、大利徹
- Organizer
  第59回天然有機化合物討論会
- Data Source
  KAKENHI-PROJECT-16K18692
[Presentation] Biosynthesis of the Carbonylmethylene Containing Pseudopeptides, Ketomemicins2017
- Author(s)
  Yasushi Ogasawara, Junpei Kawata, Taiki Naoe, Michiko Fujimori, and Tohru Dairi
- Organizer
  2nd US-Japan Seminar on the Biosynthesis of Natural Products For Young Researchers
- Place of Presentation
  Tokyo Institute of Technology, Tokyo
- Year and Date
  2017-03-04
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K18692
[Presentation] ケトメミシンの生合成に関わるアミジノ基転移酵素の機能解析2017
- Author(s)
  小笠原泰志、藤盛道子、川田純平、大利徹
- Organizer
  2017年度日本農芸化学会大会
- Place of Presentation
  京都女子大学（京都府・京都市）
- Year and Date
  2017-03-17
- Data Source
  KAKENHI-PROJECT-15H03110
[Presentation] ケトメミシンにみられるカルボニルメチレン型シュードペプチドの生合成2017
- Author(s)
  直江大樹, 川田純平, 小笠原泰志, 大利徹
- Organizer
  生合成リデザイン第１回若手シンポジウム
- Data Source
  KAKENHI-PROJECT-15H03110
[Presentation] Biosynthesis of the Carbonylmethylene Containing Pseudopeptides, Ketomemicins2017
- Author(s)
  Y. Ogasawara, J. Kawata, T. Naoe, M. Fujimori, and T. Dairi
- Organizer
  US-Japan Seminar on the Biosynthesis of Natural Products for Young Researchers
- Place of Presentation
  東京工業大学（東京都・目黒区）
- Year and Date
  2017-03-04
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15H03110
[Presentation] 放線菌に見出されたペプチドリガーゼオルソログの機能解析2017
- Author(s)
  藤村祐子、小笠原泰志、大利徹
- Organizer
  2017年度日本農芸化学会大会
- Place of Presentation
  京都女子大学、京都
- Year and Date
  2017-03-17
- Data Source
  KAKENHI-PROJECT-16K18692
[Presentation] Exploring Novel Peptide Ligase Orthologs-Discovery and Biosynthetic Studies of Carbonylmethylene-Containing Pseudotripeptides Ketomemicins-2017
- Author(s)
  Y. Ogasawara, J. Kawata, T. Naoe, M. Fujimori, M. Noike and T. Dairi
- Organizer
  Directing Biosynthesis V
- Place of Presentation
  Warwick　Univ (United Kingdom）
- Year and Date
  2017-03-22
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15H03110
[Presentation] ケトメミシンの生合成に関わるアミジノ基転移酵素の機能解析2017
- Author(s)
  小笠原泰志、藤盛道子、川田純平、大利徹
- Organizer
  2017年度日本農芸化学会大会
- Place of Presentation
  京都女子大学、京都
- Year and Date
  2017-03-17
- Data Source
  KAKENHI-PROJECT-16K18692
[Presentation] Exploring novel peptide ligase orthologs － Discovery and biosynthetic studies of carbonylmethylene-containing pseudotripeptides ketomemicins2017
- Author(s)
  Yasushi Ogasawara, Junpei Kawata, Taiki Naoe, Michiko Fujimori, and Tohru Dairi
- Organizer
  Directing Biosynthesis V
- Place of Presentation
  Warwick University, Warwick, UK
- Year and Date
  2017-03-22
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K18692
[Presentation] カルボニルメチレン構造を持つシュードトリペプチド（ケトメミシン）の発見と酵素的全合成2016
- Author(s)
  小笠原泰志、川田純平、野池基義、藤盛道子、佐藤康治、降旗一夫、大利徹
- Organizer
  第58回天然有機化合物討論会
- Place of Presentation
  東北大学百周年記念会館、仙台
- Year and Date
  2016-09-14
- Data Source
  KAKENHI-PROJECT-16K18692
[Presentation] 放線菌に見出された新規ペプチドライゲースオルソログの機能解析2016
- Author(s)
  藤村祐子、小笠原泰志、大利徹
- Organizer
  平成28年度日本農芸化学会北海道支部第２回講演会
- Place of Presentation
  北海道大学農学部、札幌
- Data Source
  KAKENHI-PROJECT-16K18692
[Presentation] 微生物に見出されたペプチドリガーゼオルソログノ機能解析2016
- Author(s)
  小笠原泰志、河田純平、佐藤康治、降旗一夫、大利徹
- Organizer
  2016年度日本農芸化学会大会
- Place of Presentation
  札幌コンベンションセンター（北海道・札幌市）
- Year and Date
  2016-03-27
- Invited
- Data Source
  KAKENHI-PROJECT-15H03110
[Presentation] Exploring peptide ligase orthologs in actinobacteria2016
- Author(s)
  Y. Ogasawara, J. Kawata, M. Noike, Y. Satoh, K. Furihata, and T. Dairi
- Organizer
  The Fifth International Conference on Cofactors (ICC-05) and Active Enzyme Molecule 2016 (AEM 2016)
- Place of Presentation
  宇奈月国際会館（富山県・黒部市）
- Year and Date
  2016-09-04
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15H03110
[Presentation] New enzymes for biosynthesis of ketomemicin, a pseudotripeptide with carbonylmethylene structure2016
- Author(s)
  Y. Ogasawara, J. Kawata, and T. Dairi
- Organizer
  5th International Conference on Novel Enzymes
- Place of Presentation
  Hampshire Hotel- Plaza Groningen (Netherlands)
- Year and Date
  2016-10-11
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15H03110
[Presentation] ケトメミシンにみられるシュードペプチド部の生合成解析2016
- Author(s)
  川田純平、直江大樹、小笠原泰志、大利徹
- Organizer
  2016年度、日本放線菌学会大会
- Place of Presentation
  東京大学（東京都・文京区）
- Year and Date
  2016-09-08
- Data Source
  KAKENHI-PROJECT-15H03110
[Presentation] フェガノマイシン、レゾルシノマイシン類抗生物質の構造活性相関2016
- Author(s)
  小笠原泰志、藤盛道子、雄谷洸一、野池基義、大利徹
- Organizer
  2016年度日本農芸化学会大会
- Place of Presentation
  札幌コンベンションセンター（北海道・札幌市）
- Year and Date
  2016-03-27
- Data Source
  KAKENHI-PROJECT-15H03110
[Presentation] ケトメミシンにみられるシュードペプチド部の生合成解析2016
- Author(s)
  川田純平、直江大樹、小笠原泰志、大利徹
- Organizer
  2016年度　日本放線菌学会大会
- Place of Presentation
  東京大学弥生講堂、東京都文京区
- Year and Date
  2016-09-08
- Data Source
  KAKENHI-PROJECT-16K18692
[Presentation] カルボニルメチレン構造を持つシュードトリペプチド（ケトメミシン）の発見と酵素的全合成2016
- Author(s)
  小笠原泰志、川田純平、野池基義、藤盛道子、佐藤康治、降旗一夫、大利徹
- Organizer
  第58回天然有機化合物討論会
- Place of Presentation
  東北大学（宮城県・仙台市）
- Year and Date
  2016-09-14
- Data Source
  KAKENHI-PROJECT-15H03110
[Presentation] 放線菌に見いだされた新規ペプチドライゲースオルソログの機能解析2015
- Author(s)
  重松真由子，小笠原泰志，大利徹
- Organizer
  2015年度日本農芸化学会北海道支部大会
- Place of Presentation
  北海道大学（北海道・札幌市）
- Year and Date
  2015-11-14
- Data Source
  KAKENHI-PROJECT-15H03110
[Presentation] Exploring Novel Peptide Ligase Orthologs in Actinobacteria2015
- Author(s)
  Y. Ogasawara, J. Kawata, M. Noike, K. Furihata and T. Dairi
- Organizer
  2nd European Conference on Natural Products
- Place of Presentation
  Goethe-Universität, Frankfurt/Main (Germany)
- Year and Date
  2015-09-06
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15H03110

1. Dairi Tohru (70264679)

# of Collaborated Projects: 2 results

# of Collaborated Products: 56 results
2. MORITA HIROYUKI (20416663)

# of Collaborated Projects: 2 results

# of Collaborated Products: 7 results
3. 濱野吉十 (50372834)

# of Collaborated Projects: 2 results

# of Collaborated Products: 7 results
4. SATOH YASUHARU (30360928)

# of Collaborated Projects: 1 results

# of Collaborated Products: 4 results
5. 勝山陽平 (50646437)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
6. MARUYAMA Chitose

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results
7. 加藤康夫

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Ogasawara Yasushi 小笠原 泰志

Research Projects

Research Products

Co-Researchers

生理活性天然物の生合成に関わる三員環構築酵素の精密解析Principal Investigator

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Dissecting biosynthetic machineries of natural peptides leading to structural and functional diversities.

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Enhancing the diversity of peptides by amino acids with reactive functional groups

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Analysis of new peptide epimerases for the biosynthesis of peptide natural productsPrincipal Investigator

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Exploring and functional analysis of peptide ligase orthologsPrincipal Investigator

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Biosynthesis of the Carbonylmethylene Structure Found in a Class of Pseudotripeptides, Ketomemicins

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[Book] ペプチド医薬品のスクリーニング・安定化・製剤化技術2017

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[Journal Article] Identification of a new oligomycin derivative as a specific inhibitor of the alternative peptidoglycan biosynthetic pathway2024

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[Journal Article] N-Formimidoylation/-iminoacetylation modification in aminoglycosides requires FAD-dependent and ligand-protein NOS bridge dual chemistry2023

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[Journal Article] Structure of lasso peptide epimerase MslH reveals metal-dependent acid/base catalytic mechanism2023

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[Journal Article] Peptide epimerase-dehydratase complex responsible for biosynthesis of the linaridin class ribosomal peptides2023

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[Journal Article] Peptide Epimerase Responsible for <scp>d</scp>-Amino Acid Introduction in Poly-γ-glutamic Acid Biosynthesis2023

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[Journal Article] First direct evidence for direct cell-membrane penetrations of polycationic homopoly(amino acid)s produced by bacteria2022

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[Journal Article] Biosynthetic Gene Cluster of Linaridin Peptides Contains Epimerase Gene2022

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Ogasawara Yasushi 小笠原泰志