Takata Tsuyoshi 高田剛

Researcher Number	20733257
Other IDs	https://orcid.org/0000-0002-6691-2569
Affiliation (Current)	2024: 東北大学, 医学系研究科, 講師
Affiliation (based on the past Project Information) *help	2022 – 2024: 東北大学, 医学系研究科, 大学院非常勤講師 2020 – 2021: 東北大学, 医学系研究科, 助教 2019: 東北大学, 医学系研究科, 学術研究員 2018: 昭和薬科大学, 薬学部, 特任助教
Review Section/Research Field	Principal Investigator Basic Section 47030:Pharmaceutical hygiene and biochemistry-related / Basic Section 46030:Function of nervous system-related Except Principal Investigator Transformative Research Areas, Section (III) / Basic Section 49050:Bacteriology-related
Keywords	Principal Investigator 超硫黄分子 / 酸化ストレス / レドックスシグナル / リン酸化修飾 / 酸化修飾 / 活性酸素 / カルモデュリンキナーゼ / 一酸化窒素 / 活性酸素種 / NO合成酵素 … More / NADPHオキシダーゼ / 硫黄プロテオミクス / 活性硫黄分子 / リン酸化酵素 / チオレドキシン / パースルフィド / 細胞内情報伝達 / 小胞体ストレス / 過酸化水素 / cAMP応答配列結合タンパク質 / カルシウムシグナル … More Except Principal Investigator 国際標準化 / 超硫黄イメージング / 超硫黄オミックス / 超硫黄分子 / タンパク質ポリサルファー化 / システインパースルフィド / 活性イオウ分子種 / 細菌 / 感染防御 / オートファジー / 細菌感染 / 硫化水素 / 活性イオウ分子 Less

NADPHオキシダーゼとNO合成酵素による活性硫黄代謝と新しい生理機能の解明Principal Investigator
- Principal Investigator
  
  高田剛
- Project Period (FY)
  2023 – 2025
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 47030:Pharmaceutical hygiene and biochemistry-related
- Research Institution
  Tohoku University
定量的超硫黄オミックス・イメージング技術の開発と標準化プロトコールの確立
- Principal Investigator
  
  赤池孝章
- Project Period (FY)
  2021 – 2025
- Research Category
  
  Grant-in-Aid for Transformative Research Areas (A)
- Review Section
  
  Transformative Research Areas, Section (III)
- Research Institution
  Tohoku University
Control of protein function and its oxidative damage by reactive persulfidesPrincipal Investigator
- Principal Investigator
  
  Takata Tsuyoshi
- Project Period (FY)
  2020 – 2022
- Research Category
  
  Grant-in-Aid for Early-Career Scientists
- Review Section
  
  Basic Section 47030:Pharmaceutical hygiene and biochemistry-related
- Research Institution
  Tohoku University
Regulatory mechanism of Ca2+/calmodulin-dependent protein kinase IV by reactive oxygen speciesPrincipal Investigator
- Principal Investigator
  
  Takata Tsuyoshi
- Project Period (FY)
  2018 – 2019
- Research Category
  
  Grant-in-Aid for Early-Career Scientists
- Review Section
  
  Basic Section 46030:Function of nervous system-related
- Research Institution
  Tohoku University
  Showa Pharmaceutical University
Novel reactive persulfide-producing system in bacteria and its involvement in bacterial pathogenicity
- Principal Investigator
  
  藤井重元
- Project Period (FY)
  2018 – 2019
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 49050:Bacteriology-related
- Research Institution
  Tohoku University

All 2023 2022 2021 2020 2019 2018

All Journal Article Presentation Book

[Book] 硫酸と工業 75(3), 超硫黄分子とその細胞内シグナル伝達への影響 ―リン酸化シグナル制御2021
- Author(s)
  荒木笙馬、高田剛、土屋幸弘、渡邊泰男
- Publisher
  硫酸協会
- Data Source
  KAKENHI-PROJECT-20K15983
[Book] 呼気オミックスと個別化医療2021
- Author(s)
  赤池孝章、松永哲郎、井田智章、高田剛、Jung Minkyung、守田匡伸、本橋ほづみ
- Total Pages
  94
- Publisher
  Precision Medicine (株)北隆館
- Data Source
  KAKENHI-PLANNED-21H05263
[Book] 超硫黄代謝物の化学と代謝2021
- Author(s)
  高田剛、松永哲郎、赤池孝章
- Total Pages
  139
- Publisher
  実験医学 (株)羊土社
- Data Source
  KAKENHI-PLANNED-21H05263
[Book] “Chapter 16: Supersulfide-mediated signaling during differentiation and de-differentiation”, In: Carsten Berndt, Christopher Horst Lillig, (eds) “Redox regulation of differentiation and de-differentiation”, in the series “Oxidative stress and disease”2021
- Author(s)
  Tsuyoshi Takata, Masanobu Morita, Tetsuro Matsunaga, Hozumi Motohashi, Takaaki Akaike
- Total Pages
  392
- Publisher
  CRC Press
- ISBN
  9780367895662
- Data Source
  KAKENHI-PROJECT-20K15983
[Book] 生化学 93(5), 超硫黄分子の化学と代謝：超硫黄生物学の創成とオミックス先制医療への展望2021
- Author(s)
  赤池孝章、松永哲郎、高田剛
- Publisher
  公益社団法人日本生化学会
- Data Source
  KAKENHI-PROJECT-20K15983
[Book] 超硫黄分子の化学と代謝:超硫黄生物学の創成とオミックス先制医療への展望2021
- Author(s)
  赤池孝章、松永哲郎、高田剛
- Total Pages
  204
- Publisher
  生化学 (公社)日本生化学会
- Data Source
  KAKENHI-PLANNED-21H05263
[Book] 実験医学 39(13), 超硫黄代謝物の化学と代謝2021
- Author(s)
  高田剛、松永哲郎、赤池孝章
- Publisher
  羊土社
- Data Source
  KAKENHI-PROJECT-20K15983
[Book] 食と健康を結ぶメディカルサイエンス, 抗酸化：活性パースルフィドによる制御2020
- Author(s)
  高田剛、松永哲郎、赤池孝章
- Total Pages
  242
- Publisher
  羊土社
- ISBN
  9784758103879
- Data Source
  KAKENHI-PROJECT-20K15983
[Book] 硫酸と工業, 活性硫黄分子の新規生合成経路とその代謝制御機能2020
- Author(s)
  高田剛、松永哲郎、赤池孝章
- Total Pages
  34
- Publisher
  硫酸協会
- Data Source
  KAKENHI-PROJECT-20K15983
[Book] 硫黄呼吸は幹細胞のエネルギー代謝を担っているか？2019
- Author(s)
  高田剛、松永哲郎、赤池孝章
- Publisher
  再生医療
- Data Source
  KAKENHI-PROJECT-18K14853
[Book] 硫黄呼吸は幹細胞のエネルギー代謝を担っているか？2019
- Author(s)
  高田剛、松永哲郎、赤池孝章
- Total Pages
  120
- Publisher
  再生医療
- ISBN
  9784779223358
- Data Source
  KAKENHI-PROJECT-18K07099
[Book] 生体の科学　増大特集　タンパク質・核酸の分子修飾　酸化還元状態 S-グルタチオニル化2018
- Author(s)
  高田剛・土屋幸弘・渡邊泰男
- Total Pages
  2
- Publisher
  医学書院
- Data Source
  KAKENHI-PROJECT-18K14853
[Journal Article] Synthesis of sulfides and persulfides is not impeded by disruption of three canonical enzymes in sulfur metabolism2023
- Author(s)
  Zainol Abidin Qamarul Hafiz、Ida Tomoaki、Morita Masanobu、Matsunaga Tetsuro、Nishimura Akira、Jung Minkyung、Hassan Naim、Takata Tsuyoshi、Ishii Isao、Kruger Warren、Wang Rui、Motohashi Hozumi、Tsutsui Masato、Akaike Takaaki
- Journal Title
  
  Antioxidants
  
  Volume: 12 Issue: 4 Pages: 868-868
- DOI
  10.3390/antiox12040868
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-22K06893, KAKENHI-PROJECT-22K19397, KAKENHI-PROJECT-19K07554, KAKENHI-PROJECT-20K07306, KAKENHI-PROJECT-20K15983
[Journal Article] Chemical biology of reactive sulfur species: Hydrolysis-driven equilibrium of polysulfides as a determinant of physiological functions.2022
- Author(s)
  Sawa Tomohiro, Takata Tsuyoshi, Matsunaga Tetsuro, Ihara Hideshi, Motohashi Hozumi, Akaike Takaaki.
- Journal Title
  
  Antioxidants & Redox Signaling
  
  Volume: 36 Issue: 4-6 Pages: 327-336
- DOI
  10.1089/ars.2021.0170
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K21496, KAKENHI-PUBLICLY-20H04832, KAKENHI-ORGANIZER-21H05258, KAKENHI-PLANNED-21H05263, KAKENHI-PLANNED-21H05264, KAKENHI-PROJECT-18H05277, KAKENHI-PROJECT-21H04799, KAKENHI-PROJECT-21H02071, KAKENHI-PROJECT-19K07554, KAKENHI-PROJECT-20K15983, KAKENHI-PROJECT-17H06170
[Journal Article] Methods in sulfide and persulfide research.2021
- Author(s)
  Takata Tsuyoshi, Jung Minkyung, Matsunaga Tetsuro, Ida Tomoaki, Morita Masanobu, Motohashi Hozumi, Shen Xinggui, Kevil Christopher G., Fukuto Jon M., Akaike Takaaki.
- Journal Title
  
  Nitric Oxide
  
  Volume: 116 Pages: 47-64
- DOI
  10.1016/j.niox.2021.09.002
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K21496, KAKENHI-PUBLICLY-20H04832, KAKENHI-ORGANIZER-21H05258, KAKENHI-PLANNED-21H05263, KAKENHI-PLANNED-21H05264, KAKENHI-PROJECT-18H05277, KAKENHI-PROJECT-21H04799, KAKENHI-PROJECT-19K07341, KAKENHI-PROJECT-19K07554, KAKENHI-PROJECT-20K07306, KAKENHI-PROJECT-20K15983, KAKENHI-PROJECT-17H06170
[Journal Article] Oxidative Stress Orchestrates MAPK and Nitric-Oxide Synthase Signal2020
- Author(s)
  Takata Tsuyoshi、Araki Shoma、Tsuchiya Yukihiro、Watanabe Yasuo
- Journal Title
  
  International Journal of Molecular Sciences
  
  Volume: 21 Issue: 22 Pages: 8750-8750
- DOI
  10.3390/ijms21228750
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K15983, KAKENHI-PROJECT-18K11083
[Journal Article] Coordination between Calcium/Calmodulin-Dependent Protein Kinase II and Neuronal Nitric Oxide Synthase in Neurons2020
- Author(s)
  Araki Shoma、Osuka Koji、Takata Tsuyoshi、Tsuchiya Yukihiro、Watanabe Yasuo
- Journal Title
  
  International Journal of Molecular Sciences
  
  Volume: 21 Issue: 21 Pages: 7997-7997
- DOI
  10.3390/ijms21217997
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K10853, KAKENHI-PROJECT-20K15983, KAKENHI-PROJECT-18K11083
[Journal Article] Control of Protein Function Through Oxidation and Reduction of Persulfidated States2020
- Author(s)
  E Doka, T Ida, M Dagnell, Y Abiko, N C Luong, N Balog, T Takata, B Espinosa, A Nishimura, Q Cheng, Y Funato, H Miki, J M Fukuto, J R Prigge, E E Schmidt, E S J Arner, Y Kumagai, T Akaike, P Nagy
- Journal Title
  
  Sci Adv
  
  Volume: 6 Issue: 1 Pages: 8358-8358
- DOI
  10.1126/sciadv.aax8358
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K19396, KAKENHI-PROJECT-19K15803, KAKENHI-PROJECT-18H05293, KAKENHI-PROJECT-17K08619, KAKENHI-PROJECT-18K07099, KAKENHI-PROJECT-16K14723, KAKENHI-PROJECT-17K15489, KAKENHI-PROJECT-18K14853, KAKENHI-PROJECT-18H05277, KAKENHI-PROJECT-17H04041, KAKENHI-PUBLICLY-20H05508, KAKENHI-PROJECT-17H06170
[Journal Article] Persulfide Signaling in Stress-Initiated Calmodulin Kinase Response2020
- Author(s)
  Takata Tsuyoshi、Araki Shoma、Tsuchiya Yukihiro、Watanabe Yasuo
- Journal Title
  
  Antioxidants & Redox Signaling
  
  Volume: 33 Issue: 18 Pages: 1308-1319
- DOI
  10.1089/ars.2020.8138
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20K15983, KAKENHI-PROJECT-18K11083
[Journal Article] The active-site cysteine residue of Ca2+/calmodulin-dependent protein kinase I is protected from irreversible modification via generation of polysulfidation2019
- Author(s)
  Takata Tsuyoshi、Tsukuda Ayaka、Tsuchiya Yukihiro、Akaike Takaaki、Watanabe Yasuo
- Journal Title
  
  Nitric Oxide
  
  Volume: 86 Pages: 68-75
- DOI
  10.1016/j.niox.2019.02.008
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K11083, KAKENHI-PLANNED-26111008, KAKENHI-PROJECT-18H05277, KAKENHI-PROJECT-18K07099, KAKENHI-PROJECT-18K14853
[Journal Article] Redox regulation of Ca2+/calmodulin-dependent protein kinase IV via oxidation of its active-site cysteine residue2019
- Author(s)
  Takata Tsuyoshi、Kimura Jun、Ihara Hideshi、Hatano Naoya、Tsuchiya Yukihiro、Watanabe Yasuo
- Journal Title
  
  Free Radical Biology and Medicine
  
  Volume: 130 Pages: 99-106
- DOI
  10.1016/j.freeradbiomed.2018.10.440
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18K11083, KAKENHI-PROJECT-16H04674, KAKENHI-PROJECT-18K14853
[Journal Article] Reactive sulfur species impair Ca2+/calmodulin-dependent protein kinase II via polysulfidation2019
- Author(s)
  Araki Shoma、Takata Tsuyoshi、Tsuchiya Yukihiro、Watanabe Yasuo
- Journal Title
  
  Biochemical and Biophysical Research Communications
  
  Volume: 508 Issue: 2 Pages: 550-555
- DOI
  10.1016/j.bbrc.2018.11.134
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18K11083, KAKENHI-PROJECT-18K14853
[Presentation] Detection of cyclic octa-sulfur (S8) formed endogenously in mammals2023
- Author(s)
  Takata T., Ida T., Matsunaga T., Morita1M., Jung M., Ogata S., Unno Y., Tsuchiya Y., Watanabe Y., Motohashi H., Yoshizawa M., Sumimoto H., Akaike T.
- Organizer
  Gordon Research Conference, Nitric Oxide
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K15983
[Presentation] A novel mechanism of sulfur metabolism catalyzed by NOX and NOS2022
- Author(s)
  Takata T., Ida T., Matsunaga T., Morita1M., Jung M., Ogata S., Unno Y., Tsuchiya Y., Murakami S., Watanabe Y., Motohashi H., Yoshizawa M., Sumimoto H., Akaike T.
- Organizer
  The 12th International Conference on the Biology, Chemistry and Therapeutic Applications of Nitric Oxide
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K15983
[Presentation] Functional diversity of calmodulin kinase I/IV in response to reactive sulfur species2022
- Author(s)
  Takata T., Tsuchiya Y., Akaike T., Watanabe Y.
- Organizer
  6TH WORLD CONGRESS ON HYDROGEN SULFIDE IN BIOLOGY & MEDICINE
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K15983
[Presentation] NADPH oxidaseによる新規活性硫黄代謝リモデリングと細菌感染防御機構2020
- Author(s)
  井田智章、松永哲郎、守田匡伸、高田　剛、住本英樹、赤池孝章
- Organizer
  第93回日本細菌学会総会
- Data Source
  KAKENHI-PROJECT-18K07099
[Presentation] NADPH酸化還元酵素による新規活性硫黄代謝機構の解明2020
- Author(s)
  高田剛、井田智章、松永哲郎、守田匡伸、土屋幸弘、渡邊泰男、住本英樹、赤池孝章
- Organizer
  第19回分子予防環境医学研究会大会
- Data Source
  KAKENHI-PROJECT-18K14853
[Presentation] カルモデュリンキナーゼIのポリスルフィド化とその意義2019
- Author(s)
  高田剛、佃彩華、土屋幸弘、赤池孝章、渡邊泰男
- Organizer
  第19回日本NO学会学術集会
- Data Source
  KAKENHI-PROJECT-18K14853
[Presentation] カルモデュリンキナーゼ群の活性イオウ分子応答性の差異2019
- Author(s)
  高田剛、土屋幸弘、赤池孝章、渡邊泰男
- Organizer
  第92回日本生化学会大会
- Data Source
  KAKENHI-PROJECT-18K14853
[Presentation] REGULATION OF CALCIUM ION/CALMODULIN-DEPENDENT PROTEIN KINASE I BY S-POLYSULFIDATION2018
- Author(s)
  Takata T., Ihara H., Tsuchiya Y., Watanabe Y.
- Organizer
  The 10th International Conference on the Biology, Chemistry, and Therapeutic Application of Nitric Oxide
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K14853
[Presentation] REACTIVE SULFUR SPECIES INHIBIT CA2+/ CALMODULIN DEPENDENT PROTEIN KINASE II ACTIVITY VIA SITE SPECIFIC S-POLYSULFIDATION2018
- Author(s)
  Araki S., Takata T., Tsuchiya Y., Watanabe Y.
- Organizer
  The 10th International Conference on the Biology, Chemistry, and Therapeutic Application of Nitric Oxide, Oxford
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K14853

1. 藤井重元 (00325333)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
2. 井田智章 (70570406)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
3. 松永哲郎 (00723206)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
4. 赤池孝章 (20231798)

# of Collaborated Projects: 1 results

# of Collaborated Products: 5 results
5. 居原秀 (60254447)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
6. WATANABE Yasuo

# of Collaborated Projects: 0 results

# of Collaborated Products: 4 results
7. OOSUKA Kouzi

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
8. 船戸洋佑

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Takata Tsuyoshi 高田 剛

Research Projects

Research Products

Co-Researchers

NADPHオキシダーゼとNO合成酵素による活性硫黄代謝と新しい生理機能の解明Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

定量的超硫黄オミックス・イメージング技術の開発と標準化プロトコールの確立

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Control of protein function and its oxidative damage by reactive persulfidesPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Regulatory mechanism of Ca2+/calmodulin-dependent protein kinase IV by reactive oxygen speciesPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Novel reactive persulfide-producing system in bacteria and its involvement in bacterial pathogenicity

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

[Book] 硫酸と工業 75(3), 超硫黄分子とその細胞内シグナル伝達への影響 ―リン酸化シグナル制御2021

Author(s)

Publisher

Data Source

[Book] 呼気オミックスと個別化医療2021

Author(s)

Total Pages

Publisher

Data Source

[Book] 超硫黄代謝物の化学と代謝2021

Author(s)

Total Pages

Publisher

Data Source

[Book] “Chapter 16: Supersulfide-mediated signaling during differentiation and de-differentiation”, In: Carsten Berndt, Christopher Horst Lillig, (eds) “Redox regulation of differentiation and de-differentiation”, in the series “Oxidative stress and disease”2021

Author(s)

Total Pages

Publisher

ISBN

Data Source

[Book] 生化学 93(5), 超硫黄分子の化学と代謝：超硫黄生物学の創成とオミックス先制医療への展望2021

Author(s)

Publisher

Data Source

[Book] 超硫黄分子の化学と代謝:超硫黄生物学の創成とオミックス先制医療への展望2021

Author(s)

Total Pages

Publisher

Data Source

[Book] 実験医学 39(13), 超硫黄代謝物の化学と代謝2021

Author(s)

Publisher

Data Source

[Book] 食と健康を結ぶメディカルサイエンス, 抗酸化：活性パースルフィドによる制御2020

Author(s)

Total Pages

Publisher

ISBN

Data Source

[Book] 硫酸と工業, 活性硫黄分子の新規生合成経路とその代謝制御機能2020

Author(s)

Total Pages

Publisher

Data Source

[Book] 硫黄呼吸は幹細胞のエネルギー代謝を担っているか？2019

Author(s)

Takata Tsuyoshi 高田剛

[Book] 生体の科学　増大特集　タンパク質・核酸の分子修飾　酸化還元状態 S-グルタチオニル化2018