Takeda Tomoya 武田朋也

… Alternative Names

武田朋也タケダトモヤ

TAKEDA Tomoya 武田朋也

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Researcher Number	20734031
Other IDs
Affiliation (Current)	2025: 大阪大谷大学, 薬学部, 准教授
Affiliation (based on the past Project Information) *help	2023: 近畿大学, 薬学部, 講師 2017 – 2021: 近畿大学, 薬学部, 助教 2017: 近畿大学, 薬学部, 助手
Review Section/Research Field	Principal Investigator Basic Section 47060:Clinical pharmacy-related / Basic Section 50010:Tumor biology-related / Medical pharmacy Except Principal Investigator Medical pharmacy
Keywords	Principal Investigator 骨微小環境 / 骨転移 / トリプルネガティブ乳癌 / 骨髄間質細胞 / ケモカイン受容体 / シグナル伝達 / 癌 / 免疫 / がん / 上皮間葉転換 / 転移 / 乳癌 … More Except Principal Investigator … More イマチニブ耐性 / BCR-ABL阻害薬 / イマチニブ / 慢性骨髄性白血病 Less

骨微小環境に着目したトリプルネガティブ乳癌の骨転移機序の解明及び治療法の開発Principal Investigator
- Principal Investigator
  
  武田朋也
- Project Period (FY)
  2023 – 2025
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 47060:Clinical pharmacy-related
- Research Institution
  Kindai University
Interaction between triple negative breast cancer and bone marrow stromal cells promote bone metastasis.Principal Investigator
- Principal Investigator
  
  Takeda Tomoya
- Project Period (FY)
  2020 – 2021
- Research Category
  
  Grant-in-Aid for Early-Career Scientists
- Review Section
  
  Basic Section 50010:Tumor biology-related
- Research Institution
  Kindai University
Zeb-1 promotes epithelial-mesenchymal transition and metastasis in breast cancerPrincipal Investigator
- Principal Investigator
  
  Takeda Tomoya
- Project Period (FY)
  2017 – 2019
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Medical pharmacy
- Research Institution
  Kindai University
Identification of imatinib resistance factor and the therapeutic strategies to overcome resistance in chronic myeloid leukemia
- Principal Investigator
  
  NISHIDA Shozo
- Project Period (FY)
  2015 – 2017
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Medical pharmacy
- Research Institution
  Kindai University

All 2024 2023 2021 2020 2018 2017 2016 2015

All Journal Article Presentation

[Journal Article] RANK/RANKL axis promotes migration, invasion, and metastasis of osteosarcoma via activating NF-κB pathway2024
- Author(s)
  Takeda Tomoya、Tsubaki Masanobu、Genno Shuji、Tomita Kana、Nishida Shozo
- Journal Title
  
  Experimental Cell Research
  
  Volume: 436 Issue: 2 Pages: 113978-113978
- DOI
  10.1016/j.yexcr.2024.113978
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23K06246
[Journal Article] HER3/Akt/mTOR pathway is a key therapeutic target for the reduction of triple?negative breast cancer metastasis via the inhibition of CXCR4 expression2023
- Author(s)
  Takeda Tomoya、Tsubaki Masanobu、Genno Shuji、Tokunaga Kenta、Tanaka Remi、Nishida Shozo
- Journal Title
  
  International Journal of Molecular Medicine
  
  Volume: 52 Issue: 3 Pages: 80-80
- DOI
  10.3892/ijmm.2023.5283
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23K06246
[Journal Article] Sorafenib treatment of metastatic melanoma with c?Kit aberration reduces tumor growth and promotes survival2021
- Author(s)
  Takeda Tomoya、Tsubaki Masanobu、Kato Natsuki、Genno Shuji、Ichimura Eri、Enomoto Aya、Imano Motohiro、Satou Takao、Nishida Shozo
- Journal Title
  
  Oncology Letters
  
  Volume: - Issue: 6 Pages: 827-827
- DOI
  10.3892/ol.2021.13089
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20K16343, KAKENHI-PROJECT-21K11181
[Journal Article] Inhibition of yes-associated protein suppresses migration, invasion, and metastasis in non-small cell lung cancer in vitro and in vivo2021
- Author(s)
  Takeda Tomoya、Tsubaki Masanobu、Genno Shuji、Matsuda Takuya、Yamamoto Yuuta、Kimura Akihiro、Shimizu Nao、Nishida Shozo
- Journal Title
  
  Clinical and Experimental Medicine
  
  Volume: - Issue: 2 Pages: 221-228
- DOI
  10.1007/s10238-021-00738-4
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20K16343
[Journal Article] AT9283 exhibits antiproliferative effect on tyrosine kinase inhibitor?sensitive and ?resistant chronic myeloid leukemia cells by inhibition of Aurora A and Aurora?B2020
- Author(s)
  Takeda Tomoya、Tsubaki Masanobu、Genno Shuji、Nemoto Chisato、Onishi Yasuka、Yamamoto Yuuta、Imano Motohiro、Satou Takao、Nishida Shozo
- Journal Title
  
  Oncology Reports
  
  Volume: 44 Pages: 2211-2218
- DOI
  10.3892/or.2020.7739
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20K16343
[Journal Article] CD49d and CD49e induce cell adhesion-mediated drug resistance through the nuclear factor-κB pathway in Burkitt lymphoma2020
- Author(s)
  Takeda Tomoya、Tsubaki Masanobu、Genno Shuji、Matsuda Takuya、Yamamoto Yuuta、Ueda Eri、 Imano Motohiro、Satou Takao、Nishida Shozo
- Journal Title
  
  JOURNAL OF PHYSIOLOGY AND PHARMACOLOGY
  
  Volume: -
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20K16343
[Journal Article] Dimethyl fumarate suppresses metastasis and growth of melanoma cells by inhibiting the nuclear translocation of NF-κB2020
- Author(s)
  Takeda Tomoya、Tsubaki Masanobu、Asano Ryota、Itoh Tatsuki、Imano Motohiro、Satou Takao、Nishida Shozo
- Journal Title
  
  Journal of Dermatological Science
  
  Volume: 99 Issue: 3 Pages: 168-176
- DOI
  10.1016/j.jdermsci.2020.07.004
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20K16343
[Journal Article] The MIP-1α autocrine loop contributes to decreased sensitivity to anticancer drugs.2018
- Author(s)
  Tsubaki M, Takeda T, Tomonari Y, Mashimo K, Koumoto YI, Hoshida S, Itoh T, Imano M, Satou T, Sakaguchi K, Nishida S.
- Journal Title
  
  J Cell Physiol.
  
  Volume: 233 Issue: 5 Pages: 4258-4271
- DOI
  10.1002/jcp.26245
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-15K08116, KAKENHI-PROJECT-16K18965
[Journal Article] Bavachin induces the apoptosis of multiple myeloma cell lines by inhibiting the activation of nuclear factor kappa B and signal transducer and activator of transcription 3.2018
- Author(s)
  Takeda T, Tsubaki M, Tomonari Y, Kawashima K, Itoh T, Imano M, Satou T, Nishida Ｓ.
- Journal Title
  
  Biomed Pharmacother.
  
  Volume: 100 Pages: 486-494
- DOI
  10.1016/j.biopha.2018.02.019
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17K15530, KAKENHI-PROJECT-15K08116
[Journal Article] Pioglitazone inhibits cancer cell growth through STAT3 inhibition and enhanced AIF expression via a PPARγ-independent pathway.2018
- Author(s)
  Tsubaki M, Takeda T, Tomonari Y, Kawashima K, Itoh T, Imano M, Satou T, Nishida S.
- Journal Title
  
  J Cell Physiol.
  
  Volume: 233 Issue: 4 Pages: 3638-3647
- DOI
  10.1002/jcp.26225
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-15K08116, KAKENHI-PROJECT-17K01486, KAKENHI-PROJECT-16K18965
[Journal Article] Rebamipide suppresses 5-fluorouracil-induced cell death via the activation of Akt/mTOR pathway and regulates the expression of Bcl-2 family proteins.2018
- Author(s)
  Tsubaki M, Takeda T, Asano RT, Matsuda T, Fujimoto SI, Itoh T, Imano M, Satou T, Nishida S.
- Journal Title
  
  Toxicol In Vitro.
  
  Volume: 46 Pages: 284-293
- DOI
  10.1016/j.tiv.2017.10.019
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-16K18965, KAKENHI-PROJECT-15K08116, KAKENHI-PROJECT-17K01486
[Journal Article] Contributions of MET activation to BCR-ABL1 tyrosine kinase inhibitor resistance in chronic myeloid leukemia cells.2017
- Author(s)
  Tsubaki M, Takeda T, Kino T, Sakai K, Itoh T, Imano M, Nakayama T, Nishio K, Satou T, Nishida S.
- Journal Title
  
  Oncotarget
  
  Volume: In press
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-15K08116
[Journal Article] Contributions of MET activation to BCR-ABL1 tyrosine kinase inhibitor resistance in chronic myeloid leukemia cells.2017
- Author(s)
  Tsubaki M, Takeda T, Kino T, Sakai K, Itoh T, Imano M, Nakayama T, Nishio K, Satou T, Nishida S.
- Journal Title
  
  Oncotarget.
  
  Volume: 8 Issue: 24 Pages: 38717-38730
- DOI
  10.18632/oncotarget.16314
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-16K18965, KAKENHI-PROJECT-15K00898, KAKENHI-PROJECT-15K08116
[Journal Article] The sensitivity of head and neck carcinoma cells to statins is related to the expression of their Ras expression status, and statin-induced apoptosis is mediated via suppression of the Ras/ERK and Ras/mTOR pathways.2017
- Author(s)
  Tsubaki M, Fujiwara D, Takeda T, Kino T, Tomonari Y, Itoh T, Imano M, Satou T, Sakaguchi K, Nishida S.
- Journal Title
  
  Clin Exp Pharmacol Physiol.
  
  Volume: 44 Issue: 2 Pages: 222-234
- DOI
  10.1111/1440-1681.12690
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-15K08116, KAKENHI-PROJECT-15K00898
[Journal Article] Statins induce apoptosis through inhibition of Ras signaling pathways and enhancement of Bim and p27 expression in human hematopoietic tumor cells.2017
- Author(s)
  Fujiwara D, Tsubaki M, Takeda T, Tomonari Y, Koumoto YI, Sakaguchi K, Nishida S.
- Journal Title
  
  Tumour Biol.
  
  Volume: 39 Pages: 0-11
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-15K08116
[Journal Article] Mangiferin induces apoptosis in multiple myeloma cell lines by suppressing the activation of nuclear factor kappa B-inducing kinase.2016
- Author(s)
  Takeda T, Tsubaki M, Kino T, Yamagishi M, Iida M, Itoh T, Imano M, Tanabe G, Muraoka O, Satou T, Nishida S.
- Journal Title
  
  Chem Biol Interact.
  
  Volume: 251 Pages: 26-33
- DOI
  10.1016/j.cbi.2016.03.018
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-15K08116, KAKENHI-PROJECT-16K08313
[Journal Article] Mangiferin enhances the sensitivity of human multiple myeloma cells to anticancer drugs through suppression of the nuclear factor κB pathway2016
- Author(s)
  Takeda T, Tsubaki M, Kino T, Kawamura A, Isoyama S, Itoh T, Imano M, Tanabe G, Muraoka O, Satou T, Nishida S
- Journal Title
  
  Int J Oncol
  
  Volume: 48 Issue: 6 Pages: 303-309
- DOI
  10.3892/ijo.2016.3470
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-26350597, KAKENHI-PROJECT-15K00898, KAKENHI-PROJECT-15K08116, KAKENHI-PROJECT-16K08313
[Journal Article] RANK-RANKL interactions are involved in cell adhesion-mediated drug resistance in multiple myeloma cell lines.2016
- Author(s)
  Tsubaki M, Takeda T, Yoshizumi M, Ueda E, Itoh T, Imano M, Satou T, Nishida S.
- Journal Title
  
  Tumour Biol.
  
  Volume: 37 Issue: 7 Pages: 9099-9110
- DOI
  10.1007/s13277-015-4761-8
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-15K08116
[Journal Article] Statins inhibited the MIP-1α expression via inhibition of Ras/ERK and Ras/Akt pathways in myeloma cells.2016
- Author(s)
  Tsubaki M, Mashimo K, Takeda T, Kino T, Fujita A, Itoh T, Imano M, Sakaguchi K, Satou T, Nishida S.
- Journal Title
  
  Biomed Pharmacother.
  
  Volume: 78 Pages: 23-29
- DOI
  10.1016/j.biopha.2015.12.017
- Peer Reviewed / Acknowledgement Compliant / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K08116, KAKENHI-PROJECT-26350597, KAKENHI-PROJECT-15K00898
[Journal Article] Mangiferin, a novel nuclear factor kappa B-inducing kinase inhibitor, suppresses metastasis and tumor growth in a mouse metastatic melanoma model.2016
- Author(s)
  Takeda T, Tsubaki M, Sakamoto K, Ichimura E, Enomoto A, Suzuki Y, Itoh T, Imano M, Tanabe G, Muraoka O, Matsuda H, Satou T, Nishida S.
- Journal Title
  
  Toxicol Appl Pharmacol.
  
  Volume: 306 Pages: 105-112
- DOI
  10.1016/j.taap.2016.07.005
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-15K08116, KAKENHI-PROJECT-16K08313
[Journal Article] Overexpression of survivin via activation of ERK1/2, Akt, and NF-κB plays a central role in vincristine resistance in multiple myeloma cells.2015
- Author(s)
  Tsubaki M, Takeda T, Ogawa N, Sakamoto K, Shimaoka H, Fujita A, Itoh T, Imano M, Ishizaka T, Satou T, Nishida S.
- Journal Title
  
  Leuk Res.
  
  Volume: 39 Issue: 4 Pages: 445-52
- DOI
  10.1016/j.leukres.2015.01.016
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-24590224, KAKENHI-PROJECT-15K08116
[Journal Article] Statins improve survival by inhibiting spontaneous metastasis and tumor growth in a mouse melanoma model.2015
- Author(s)
  Tsubaki M, Takeda T, Kino T, Obata N, Itoh T, Imano M, Mashimo K, Fujiwara D, Sakaguchi K, Satou T, Nishida S.
- Journal Title
  
  Am J Cancer Res.
  
  Volume: 5 Pages: 3186-3197
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-15K08116
[Presentation] AT9283 によるイマチニブ感受性及び耐性慢性骨髄性白血病細胞における Aurora A 及び Aurora B阻害を介した細胞死誘導効果2021
- Author(s)
  武田朋也、椿正寛、松田拓弥、山本裕太、岸本佳奈、森井悠介、西田升三
- Organizer
  第25回日本がん分子標的治療学会学術集会
- Data Source
  KAKENHI-PROJECT-20K16343
[Presentation] AT9283 induces apoptosis via inhibition of Aurora kinase in imatinib sensitive and resistance CML cells2021
- Author(s)
  Tomoya Takeda, Masanobu Tsubaki, Takuya Matsuda, Yuuta Yamamoto, Kana Kishimoto, Shozo Nishida
- Organizer
  第80回日本癌学会学術総会
- Data Source
  KAKENHI-PROJECT-20K16343
[Presentation] Dimethyl fumarate suppresses tumor growth and metastasis of metastatic melanoma by inhibiting the nuclear translocation of NF-κB.2021
- Author(s)
  Tomoya Takeda, Masanobu Tsubaki, Shozo Nishida
- Organizer
  The 4rd International Cancer Research Symposium of Training Plan for Oncology Professionals
- Data Source
  KAKENHI-PROJECT-20K16343
[Presentation] Sorafenib inhibits the tumor growth and metastasis through suppression of receptor tyrosine kinase pathway in melanoma.2020
- Author(s)
  Tomoya Takeda, Masanobu Tsubaki, Shuji Genno, Shozo Nishida.
- Organizer
  第79回日本癌学会学術総会
- Data Source
  KAKENHI-PROJECT-20K16343
[Presentation] Sorafenibによるマルチキナーゼ阻害での悪性黒色腫での腫瘍増殖・転移抑制効果2020
- Author(s)
  武田朋也、椿正寛、源野秀次、山本裕太、西田升三
- Organizer
  第24回日本がん分子標的治療学会学術集会
- Data Source
  KAKENHI-PROJECT-20K16343
[Presentation] 新規NF-kappaB/STAT3 阻害剤による多発性骨髄腫でのアポトーシス誘導機構の解析.2018
- Author(s)
  小泉翔太郎, 椿正寛, 武田朋也, 浅野良太, 川島啓司, 西田升三.
- Organizer
  日本薬学会第138回年会
- Data Source
  KAKENHI-PROJECT-15K08116
[Presentation] 多発性骨髄腫でのMIP-1alphaオートクラインは抗がん剤の感受性を低下させ抗がん剤耐性に寄与する.2017
- Author(s)
  河本雄一, 椿正寛, 武田朋也, 友成佳加, 浅野良太, 川島啓司, 眞下恵次, 阪口勝彦, 西田升三.
- Organizer
  第21回日本がん分子標的治療学会学術集会
- Data Source
  KAKENHI-PROJECT-15K08116
[Presentation] MET/ERK and MET/JNK pathways is involved with imatinibresistance in chronic myeloid leukemia.2017
- Author(s)
  Masanobu Tsubaki, Tomoya Takeda, Yu-ichi Koumoto, Shin-ichiro Fujimoto, Shozo Nishida.
- Organizer
  第76回日本癌学会学術総会
- Data Source
  KAKENHI-PROJECT-15K08116
[Presentation] PioglitazoneはSTAT3阻害を介してSurvivinの発現低下及びAIFの発現増加によりアポトーシスを誘導する.2017
- Author(s)
  浅野良太, 椿正寛, 武田朋也, 友成佳加, 藤原大一朗, 阪口勝彦, 西田升三.
- Organizer
  第21回日本がん分子標的治療学会学術集会
- Data Source
  KAKENHI-PROJECT-15K08116
[Presentation] Statins によるRas/ERK 及びRas/mTOR 経路阻害を介した造血器系腫瘍でのアポトーシス誘導機序.2017
- Author(s)
  伊藤麻祐, 椿正寛, 武田朋也, 友成佳加, 西田升三.
- Organizer
  第67回日本薬学会近畿支部総会・大会
- Data Source
  KAKENHI-PROJECT-15K08116
[Presentation] 慢性骨髄性白血病におけるイマチニブ耐性にMET活性化が関与する2016
- Author(s)
  椿正寛、武田朋也、木野稔己、友成佳加、眞下恵次、藤原大一朗、藤本伸一郎、阪口勝彦、山添譲、西田升三.
- Organizer
  第20回日本がん分子標的治療学会
- Place of Presentation
  別府国際コンベンションセンター（大分県別府市）
- Year and Date
  2016-05-31
- Data Source
  KAKENHI-PROJECT-15K08116
[Presentation] MET activation is involved with imatinib-resistance in chronic myeloid leukemia.2016
- Author(s)
  椿正寛、武田朋也、木野稔己、友成佳加、藤本伸一郎、西田升三.
- Organizer
  第75回日本癌学会学術総会
- Place of Presentation
  パシフィコ横浜（神奈川県横浜市）
- Year and Date
  2016-10-07
- Data Source
  KAKENHI-PROJECT-15K08116

1. NISHIDA Shozo (40208187)

# of Collaborated Projects: 1 results

# of Collaborated Products: 18 results
2. TSUBAKI Masanobu (30434856)

# of Collaborated Projects: 1 results

# of Collaborated Products: 20 results
3. ITOH Tatsuki

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
4. SATOU Takao

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Takeda Tomoya 武田 朋也

武田 朋也 タケダ トモヤ

TAKEDA Tomoya 武田 朋也

Research Projects

Research Products

Co-Researchers

骨微小環境に着目したトリプルネガティブ乳癌の骨転移機序の解明及び治療法の開発Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Interaction between triple negative breast cancer and bone marrow stromal cells promote bone metastasis.Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Zeb-1 promotes epithelial-mesenchymal transition and metastasis in breast cancerPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Identification of imatinib resistance factor and the therapeutic strategies to overcome resistance in chronic myeloid leukemia

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] RANK/RANKL axis promotes migration, invasion, and metastasis of osteosarcoma via activating NF-κB pathway2024

Author(s)

Journal Title

DOI

Data Source

[Journal Article] HER3/Akt/mTOR pathway is a key therapeutic target for the reduction of triple?negative breast cancer metastasis via the inhibition of CXCR4 expression2023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Sorafenib treatment of metastatic melanoma with c?Kit aberration reduces tumor growth and promotes survival2021

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Inhibition of yes-associated protein suppresses migration, invasion, and metastasis in non-small cell lung cancer in vitro and in vivo2021

Author(s)

Journal Title

DOI

Data Source

[Journal Article] AT9283 exhibits antiproliferative effect on tyrosine kinase inhibitor?sensitive and ?resistant chronic myeloid leukemia cells by inhibition of Aurora A and Aurora?B2020

Author(s)

Journal Title

DOI

Data Source

[Journal Article] CD49d and CD49e induce cell adhesion-mediated drug resistance through the nuclear factor-κB pathway in Burkitt lymphoma2020

Author(s)

Journal Title

Data Source

[Journal Article] Dimethyl fumarate suppresses metastasis and growth of melanoma cells by inhibiting the nuclear translocation of NF-κB2020

Author(s)

Journal Title

DOI

Data Source

[Journal Article] The MIP-1α autocrine loop contributes to decreased sensitivity to anticancer drugs.2018

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Bavachin induces the apoptosis of multiple myeloma cell lines by inhibiting the activation of nuclear factor kappa B and signal transducer and activator of transcription 3.2018

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Pioglitazone inhibits cancer cell growth through STAT3 inhibition and enhanced AIF expression via a PPARγ-independent pathway.2018

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Rebamipide suppresses 5-fluorouracil-induced cell death via the activation of Akt/mTOR pathway and regulates the expression of Bcl-2 family proteins.2018

Takeda Tomoya 武田朋也

武田朋也タケダトモヤ

TAKEDA Tomoya 武田朋也