Yamazoe Taiji 山添太士

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YAMAZOE Taiji 山添太士

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Researcher Number	20736219
Affiliation (Current)	2025: 国立健康危機管理研究機構, 国立国際医療研究所肝炎・免疫研究センター, 上級研究員
Affiliation (based on the past Project Information) *help	2020 – 2024: 国立研究開発法人国立国際医療研究センター, 肝炎・免疫研究センター, 肝疾患研究部上級研究員 2014: 熊本大学, 発生医学研究所, 特定事業研究員 2014: 熊本大学, 発生医学研究所, 研究員
Review Section/Research Field	Principal Investigator Basic Section 53010:Gastroenterology-related / Gastroenterology Except Principal Investigator Basic Section 49030:Experimental pathology-related / Basic Section 53010:Gastroenterology-related
Keywords	Principal Investigator 肝細胞癌 / 非アルコール性脂肪性肝炎 / マウス担癌モデル / 発がん / ヘテロ不均一 / シングルセル調製法 / 空間的遺伝子解析 / 慢性肝疾患 / 細胞核画像解析 / iPS細胞 … More / 肝細胞分化誘導法 / ケミカルスクリーニング / 肝細胞成熟化 / iPS細胞由来肝細胞 … More Except Principal Investigator 慢性肝疾患 / 造血幹細胞 / 肝臓免疫 / 肝硬変 / 肝臓ー骨髄連関 / マルチオミクス解析 / エピゲノム制御薬 / マイクロRNA / 肝発癌進展 / 代謝リプログラミング / NASH / 脂質代謝 / エピゲノム / 肝癌細胞 / 栄養環境 / LSD2 / STC2 / 脂肪肝 / 小胞体ストレス / 酸化ストレス / 栄養・代謝環境 / エピゲノム制御 Less

慢性肝疾患における肝臓ー骨髄連関を介した新規病態制御機構の解明
- Principal Investigator
  
  森泰三
- Project Period (FY)
  2024 – 2026
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 49030:Experimental pathology-related
- Research Institution
  National Center for Global Health and Medicine
新規疾患マウスモデルを利用した非アルコール性脂肪肝炎肝癌の新たな治療標的の同定Principal Investigator
- Principal Investigator
  
  山添太士
- Project Period (FY)
  2024 – 2026
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 53010:Gastroenterology-related
- Research Institution
  National Center for Global Health and Medicine
Elucidation of nutrition-induced epigenetic changes in hepatocytes and their application to the regulation of hepatocellular carcinoma development and progression.
- Principal Investigator
  
  SASAKI Yutaka
- Project Period (FY)
  2021 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 53010:Gastroenterology-related
- Research Institution
  Kumamoto University
  Nagasaki International University
The study of hepatocyte heterogeneity in chronic liver disease progression and oncogenesisPrincipal Investigator
- Principal Investigator
  
  Yamazoe Taiji
- Project Period (FY)
  2020 – 2023
- Research Category
  
  Grant-in-Aid for Early-Career Scientists
- Review Section
  
  Basic Section 53010:Gastroenterology-related
- Research Institution
  National Center for Global Health and Medicine
Identification of hepatic maturation mechanisms of human iPS cells by using chemical screeningPrincipal Investigator
- Principal Investigator
  
  YAMAZOE Taiji
- Project Period (FY)
  2014
- Research Category
  
  Grant-in-Aid for Research Activity Start-up
- Research Field
  
  Gastroenterology
- Research Institution
  Kumamoto University

All 2024 2023 2022 2021 2020 2014 Other

All Journal Article Presentation Book

[Book] 肝臓クリニカルアップデート2022
- Author(s)
  山添太士、考藤達哉
- Total Pages
  90
- Publisher
  医学図書出版
- Data Source
  KAKENHI-PROJECT-20K17038
[Journal Article] Differences in branched-chain amino acid to tyrosine ratio (BTR) among etiologies of chronic liver disease progression compared to healthy adults.2024
- Author(s)
  Mino Masaaki、Sano Akitoshi、Kakazu Eiji、Matsubara Hiroko、Kakisaka Keisuke、Kogure Takayuki、Sekine Katsunori、Aoki Yoshihiko、Imamura Masatoshi、Matsuda Michitaka、Yamazoe Taiji、Mori Taizo、Yoshio Sachiyo、Inoue Jun、Masamune Atsushi、Kanto Tatsuya
- Journal Title
  
  Journal of Gastroenterology
  
  Volume: - Issue: 6 Pages: 483-493
- DOI
  10.1007/s00535-024-02092-0
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20K17038
[Journal Article] Toll‐like receptor 7 agonist, GS‐986, is an immune‐stimulant inducing follicular helper T cells and expanding HBs antigen‐specific B cells <i>in vitro</i>2023
- Author(s)
  Mori Taizo、Yoshio Sachiyo、Yoshikawa Shiori、Tsustui Yuriko、Sakata Toshihiro、Yoshida Yuichi、Sakamoto Yuzuru、Kawai Hironari、Osawa Yosuke、Yamazoe Taiji、Aoki Yoshihiko、Fletcher Simon P.、Kanto Tatsuya
- Journal Title
  
  Liver International
  
  Volume: 43 Issue: 6 Pages: 1213-1224
- DOI
  10.1111/liv.15568
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23K15507, KAKENHI-PROJECT-21K08014, KAKENHI-PROJECT-21K07904, KAKENHI-PROJECT-20K17038
[Journal Article] Serum osteopontin predicts the response to atezolizumab plus bevacizumab in patients with hepatocellular carcinoma2023
- Author(s)
  Yamauchi Reika、Ito Takanori、Yoshio Sachiyo、Yamamoto Takafumi、Mizuno Kazuyuki、Ishigami Masatoshi、Kawashima Hiroki、Yasuda Satoshi、Shimose Shigeo、Iwamoto Hideki、Yamazoe Taiji、Mori Taizo、Kakazu Eiji、Kawaguchi Takumi、Toyoda Hidenori、Kanto Tatsuya
- Journal Title
  
  Journal of Gastroenterology
  
  Volume: - Issue: 6 Pages: 565-574
- DOI
  10.1007/s00535-023-01985-w
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21K08020, KAKENHI-PROJECT-20K17038, KAKENHI-PROJECT-21K07904
[Journal Article] Exercise changes the intrahepatic immune cell profile and inhibits the progression of nonalcoholic steatohepatitis in a mouse model2023
- Author(s)
  Tsutsui Yuriko、Mori Taizo、Yoshio Sachiyo、Sato Miku、Sakata Toshihiro、Yoshida Yuichi、Kawai Hironari、Yoshikawa Shiori、Yamazoe Taiji、Matsuda Michitaka、Kakazu Eiji、Osawa Yosuke、Oyama Chinatsu、Tamura-Nakano Miwa、Kawaguchi Takumi、Yoshizumi Tomoharu、Kanto Tatsuya
- Journal Title
  
  Hepatology Communications
  
  Volume: 7 Issue: 10
- DOI
  10.1097/hc9.0000000000000236
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-21K08014, KAKENHI-PROJECT-21K07904, KAKENHI-PROJECT-20K17038
[Journal Article] Effects of sodium glucose cotransporter 2 inhibitors and pioglitazone on FIB‐4 index in metabolic‐associated fatty liver disease2023
- Author(s)
  Mino Masaaki、Kakazu Eiji、Sano Akitoshi、Katsuyama Hisayuki、Hakoshima Mariko、Yanai Hidekatsu、Aoki Yoshihiko、Imamura Masatoshi、Yamazoe Taiji、Mori Taizo、Yoshio Sachiyo、Inoue Jun、Masamune Atsushi、Kanto Tatsuya
- Journal Title
  
  Hepatology Research
  
  Volume: - Issue: 7 Pages: 618-628
- DOI
  10.1111/hepr.13898
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20K17038, KAKENHI-PROJECT-20K08322, KAKENHI-PROJECT-21K07904
[Journal Article] Dried blood spot-based host genome analysis technique targeting pathological associations with hepatitis B: Development and clinical application in the Cambodian population.2023
- Author(s)
  Setoyama H, Yamazoe T, Kanto T et al.
- Journal Title
  
  Hepatol Res
  
  Volume: 12 Issue: 12 Pages: 1147-1155
- DOI
  10.1111/hepr.13949
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-21K07904, KAKENHI-PROJECT-20K17038, KAKENHI-PROJECT-21K15953
[Journal Article] Peripheral‐dominant liver fibrosis and tumor distribution in a mouse model of congestive hepatopathy2022
- Author(s)
  Kawai Hironari、Osawa Yosuke、et al.
- Journal Title
  
  Hepatology Research
  
  Volume: 53 Issue: 4 Pages: 370-376
- DOI
  10.1111/hepr.13866
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21K08014, KAKENHI-PROJECT-20K17038, KAKENHI-PROJECT-21K07904, KAKENHI-PROJECT-23K27671
[Journal Article] Calcium signaling induces a partial EMT2021
- Author(s)
  NorgardJason RJ, Yamazoe T, Stranger BZ, et al.
- Journal Title
  
  EMBO Reports
  
  Volume: - Issue: 9
- DOI
  10.15252/embr.202051872
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21K07904, KAKENHI-PROJECT-20K17038
[Journal Article] Phenotypic Characterization by Single-Cell Mass Cytometry of Human Intrahepatic and Peripheral NK Cells in Patients with Hepatocellular Carcinoma2021
- Author(s)
  Yoshida Yuichi、Yoshio Sachiyo、Yamazoe Taiji、Mori Taizo、Tsustui Yuriko、Kawai Hironari、Yoshikawa Shiori、Fukuhara Takasuke、Okamoto Toru、Ono Yoshihiro、Takahashi Yu、Hashida Ryuki、Kawaguchi Takumi、Taketomi Akinobu、Kanto Tatsuya
- Journal Title
  
  Cells
  
  Volume: 10 Issue: 6 Pages: 1495-1495
- DOI
  10.3390/cells10061495
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-21K08020, KAKENHI-PROJECT-20K17038
[Journal Article] Myostatin as a fibroblast‐activating factor impacts on postoperative outcome in patients with hepatocellular carcinoma2021
- Author(s)
  Yoshio Sachiyo、Shimagaki Tomonari、Hashida Ryuki、Kawaguchi Takumi、Tsutsui Yuriko、Sakamoto Yuzuru、Yoshida Yuichi、Kawai Hironari、Yoshikawa Shiori、Yamazoe Taiji、Mori Taizo、Osawa Yosuke、Itoh Shinji、Fukai Moto、Yoshizumi Tomoharu、Taketomi Akinobu、Mori Masaki、Kanto Tatsuya
- Journal Title
  
  Hepatology Research
  
  Volume: 51 Issue: 7 Pages: 803-812
- DOI
  10.1111/hepr.13667
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-21K08014, KAKENHI-PROJECT-20K17038
[Journal Article] Sphingosine‐1‐phosphate promotes tumor development and liver fibrosis in mouse model of congestive hepatopathy2021
- Author(s)
  Kawai H, Osawa Y, Matsuda M, Tsunoda T, Yanagida K, Hishikawa D, Okawara M, Sakamoto Y, Shimagaki T, Tsutsui Y, Yoshida Y, Yoshikawa S, Hashi K, Doi H, Mori T, Yamazoe T, Yoshio S, Sugiyama M, Okuzaki D, Komatsu H, Inui A, Tamura-Nakano M, Oyama C, Shindou H, Kusano H, Kage M, Ikegami T, Yanaga K, Kanto T
- Journal Title
  
  Hepatology
  
  Volume: - Issue: 1 Pages: 112-125
- DOI
  10.1002/hep.32256
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K08900, KAKENHI-PROJECT-21K07904, KAKENHI-PROJECT-21K08014, KAKENHI-PROJECT-20K17038
[Journal Article] Mutant p53 regulates Survivin to foster lung metastasis2021
- Author(s)
  Tang Q.、Efe G.、Chiarella A.、Leung J.、Chen M.、Yamazoe T.、Su Z.、Pitarresi J.、Li J.、Islam M.、Karakasheva T.、Klein-Szanto A.、Pan S.、Hu J.、Natsugoe S.、Gu W.、Stanger B.、Wong K.、Diehl A.、Bass A.、Nakagawa H.、Murphy M.、Rustgi A.
- Journal Title
  
  Genes & Development
  
  Volume: 35 Issue: 7-8 Pages: 528-541
- DOI
  10.1101/gad.340505.120
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K17038
[Journal Article] Cluster of Differentiation 44 Promotes Liver Fibrosis and Serves as a Biomarker in Congestive Hepatopathy2021
- Author(s)
  Osawa Y, Kawai H, Yamazoe T, Kanto T, et al.
- Journal Title
  
  Hepatology Communications
  
  Volume: 5 Issue: 8 Pages: 1437-1447
- DOI
  10.1002/hep4.1721
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-21K07904, KAKENHI-PROJECT-21K08014, KAKENHI-PROJECT-20K17038
[Journal Article] Blood angiopoietin-2 predicts liver angiogenesis and fibrosis in hepatitis C patients2021
- Author(s)
  Osawa Yosuke、Yoshio Sachiyo、Aoki Yoshihiko、Korenaga Masaaki、Imamura Masatoshi、Oide Takashi、Okawara Miku、Kawai Hironari、Tsutsui Yuriko、Yoshida Yuichi、Yoshikawa Shiori、Mori Taizo、Yamazoe Taiji、Kanto Tatsuya
- Journal Title
  
  BMC Gastroenterology
  
  Volume: 21 Issue: 1 Pages: 000-000
- DOI
  10.1186/s12876-021-01633-8
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K17038, KAKENHI-PROJECT-21K08014
[Journal Article] Impact of Immune Reconstitution-Induced Hepatic Flare on Hepatitis B Surface Antigen Loss in Hepatitis B Virus/Human Immunodeficiency Virus-1 Coinfected Patients2020
- Author(s)
  Yoshikawa Shiori、Yoshio Sachiyo、Yoshida Yuichi、Tsutsui Yuriko、Kawai Hironari、Yamazoe Taiji、Mori Taizo、Osawa Yosuke、Sugiyama Masaya、Iwamoto Masashi、Watashi Koichi、Kawaguchi Takumi、Akita Tomoyuki、Tanaka Junko、Kikuchi Yoshimi、Mizokami Masashi、Oka Shinichi、Kanto Tatsuya、Gatanaga Hiroyuki
- Journal Title
  
  The Journal of Infectious Diseases
  
  Volume: - Issue: 12 Pages: 2080-2089
- DOI
  10.1093/infdis/jiaa662
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20K17038
[Journal Article] Global Regulation of the Histone Mark H3K36me2 Underlies Epithelial Plasticity and Metastatic Progression2020
- Author(s)
  Yuan Salina、Natesan Ramakrishnan、Sanchez-Rivera Francisco J.、Li Jinyang、Bhanu Natarajan V.、Yamazoe Taiji、Lin Jeffrey H.、Merrell Allyson J.、Sela Yogev、Thomas Stacy K.、Jiang Yanqing、Plesset Jacqueline B.、Miller Emma M.、Shi Junwei、Garcia Benjamin A.、Lowe Scott W.、Asangani Irfan A.、Stanger Ben Z.
- Journal Title
  
  Cancer Discovery
  
  Volume: 10 Issue: 6 Pages: 854-871
- DOI
  10.1158/2159-8290.cd-19-1299
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K17038
[Journal Article] Hepatocyte ploidy and pathological mutations in hepatocellular carcinoma: impact on oncogenesis and therapeutics2020
- Author(s)
  Yamazoe Taiji、Mori Taizo、Yoshio Sachiyo、Kanto Tatsuya
- Journal Title
  
  Global Health & Medicine
  
  Volume: 2 Issue: 5 Pages: 273-281
- DOI
  10.35772/ghm.2020.01089
- NAID
  130007936750
- ISSN
  2434-9186, 2434-9194
- Year and Date
  2020-10-31
- Language
  English
- Open Access
- Data Source
  KAKENHI-PROJECT-20K17038
[Journal Article] Hepatic differentiation from murine and human iPS cells using nanofiber scaffolds2014
- Author(s)
  Yamazoe T., Shiraki N., Kume S.
- Journal Title
  
  Methods Mol Biol.
  
  Volume: epub Pages: 475-83
- DOI
  10.1007/7651_2014_138
- ISBN
  9781493930548, 9781493930555
- Data Source
  KAKENHI-PROJECT-26893201, KAKENHI-PROJECT-26461638
[Presentation] HBV持続感染者の肝炎増悪期の末梢血単核細胞を用いたシングルセル解析2022
- Author(s)
  山添太士、由雄祥代、考藤達哉
- Organizer
  第58回日本肝臓学会総会
- Data Source
  KAKENHI-PROJECT-20K17038
[Presentation] 肝がん合併非アルコール性脂肪肝炎(NASH)における肝細胞倍体性変化の検討2020
- Author(s)
  山添太士、吉田祐一、筒井由梨子、河合裕成、吉川詩織、森泰三、由雄祥代、大澤陽介、考藤達哉
- Organizer
  第24回日本肝臓学会大会
- Data Source
  KAKENHI-PROJECT-20K17038
[Presentation] 薬剤スクリーニングによるヒト誘導多能性幹細胞の肝成熟化メカニズムの解明
- Author(s)
  山添太士、佐々木裕
- Organizer
  第51回肝臓学会
- Place of Presentation
  熊本市ホテル日航
- Year and Date
  2015-05-21 – 2015-05-22
- Data Source
  KAKENHI-PROJECT-26893201

1. SASAKI Yutaka (70235282)

# of Collaborated Projects: 3 results

# of Collaborated Products: 1 results
2. KUME Shoen (70347011)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
3. SHIRAKI Nobuaki (70448520)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
4. 長岡克弥 (00759524)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
5. 渡邊丈久 (20634843)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
6. 吉村亮二 (20782569)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
7. 森泰三 (40625307)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
8. OSAWA Yosuke

# of Collaborated Projects: 0 results

# of Collaborated Products: 3 results
9. OKAMOTO Toru

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
10. YANAGIDA Keisuke

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
11. 河合裕成

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
12. 由雄祥代

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results

Yamazoe Taiji 山添 太士

YAMAZOE Taiji 山添 太士

Research Projects

Research Products

Co-Researchers

慢性肝疾患における肝臓ー骨髄連関を介した新規病態制御機構の解明

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

新規疾患マウスモデルを利用した非アルコール性脂肪肝炎肝癌の新たな治療標的の同定Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Elucidation of nutrition-induced epigenetic changes in hepatocytes and their application to the regulation of hepatocellular carcinoma development and progression.

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

The study of hepatocyte heterogeneity in chronic liver disease progression and oncogenesisPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Identification of hepatic maturation mechanisms of human iPS cells by using chemical screeningPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Book] 肝臓クリニカルアップデート2022

Author(s)

Total Pages

Publisher

Data Source

[Journal Article] Differences in branched-chain amino acid to tyrosine ratio (BTR) among etiologies of chronic liver disease progression compared to healthy adults.2024

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Toll‐like receptor 7 agonist, GS‐986, is an immune‐stimulant inducing follicular helper T cells and expanding HBs antigen‐specific B cells <i>in vitro</i>2023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Serum osteopontin predicts the response to atezolizumab plus bevacizumab in patients with hepatocellular carcinoma2023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Exercise changes the intrahepatic immune cell profile and inhibits the progression of nonalcoholic steatohepatitis in a mouse model2023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Effects of sodium glucose cotransporter 2 inhibitors and pioglitazone on FIB‐4 index in metabolic‐associated fatty liver disease2023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Dried blood spot-based host genome analysis technique targeting pathological associations with hepatitis B: Development and clinical application in the Cambodian population.2023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Peripheral‐dominant liver fibrosis and tumor distribution in a mouse model of congestive hepatopathy2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Calcium signaling induces a partial EMT2021

Author(s)

Journal Title

DOI

Data Source

Yamazoe Taiji 山添太士

YAMAZOE Taiji 山添太士